176 results on '"Gopalakrishnan, Sujatha"'
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2. Development of a sensitive high-throughput enzymatic assay capable of measuring sub-nanomolar inhibitors of SARS-CoV2 Mpro
3. Collaborative robotics to enable ultra-high-throughput IR-MALDESI
4. Off-target pharmacological activity at various kinases: Potential functional and pathological side effects
5. Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site
6. MEK1/2 activity modulates TREM2 cell surface recruitment
7. Metabolite Fingerprinting for Phenotypic Screening by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry
8. Implementation of a human podocyte injury model of chronic kidney disease for profiling of renoprotective compounds
9. A-306989, an inhibitor of adenosine kinase, is renoprotective in rodent models of podocyte, basement membrane, and obstructive injury
10. Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis
11. New Platform for Label-Free, Proximal Cellular Pharmacodynamic Assays: Identification of Glutaminase Inhibitors Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry
12. Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo
13. Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity
14. A New Platform for Label-Free, Proximal Cellular Pharmacodynamic Assays: Identification of Glutaminase Inhibitors Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry
15. A screen for modulation of nucleocapsid protein condensation identifies small molecules with anti-coronavirus activity
16. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) Induces Phosphorylation of Eukaryotic Elongation Factor-2 (eEF2): A CAUTIONARY NOTE ON THE ANTICANCER MECHANISM OF AN eEF2 KINASE INHIBITOR
17. A Thallium Transport FLIPR-Based Assay for the Identification of KCC2-Positive Modulators
18. The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy
19. Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists
20. High-Throughput Label-Free Biochemical Assays Using Infrared Matrix-Assisted Desorption Electrospray Ionization Mass Spectrometry
21. An offline-addition format for identifying GPCR modulators by screening 384-well mixed compounds in the FLIPR
22. Application of Large-Scale Transient Transfection to Cell-Based Functional Assays for Ion Channels and GPCRs
23. Small Molecule Phenotypic Screen Identifies Novel Regulators of LDLR Expression
24. High Throughput Screening Assays for G Protein-Coupled Receptors
25. Trends in contact lens–associated microbial keratitis in Southern India
26. A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors
27. Fragment-based discovery of a potent NAMPT inhibitor
28. Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses
29. Validation of FLIPR Membrane Potential Dye for High Throughput Screening of Potassium Channel Modulators
30. HTS beyond the human genome
31. Evaluation of Electrochemiluminescent Technology for Inhibitors of Granulocyte Colony-Stimulating Factor Receptor Binding
32. Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design
33. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315
34. A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators
35. Chapter Seventeen - Application of Large-Scale Transient Transfection to Cell-Based Functional Assays for Ion Channels and GPCRs
36. Development and Validation of a Fluorescence-Based HTS Assay for the Identification of P/Q-Type Calcium Channel Blockers
37. Functional Characterization and High-Throughput Screening of Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors in IMR-32 Neuroblastoma Cells
38. Identification and Characterization of mGlu3 Ligands Using a High Throughput FLIPR Assay for Detection of Agonists, Antagonists, and Allosteric Modulators
39. In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107
40. Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
41. Structure−Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H4Receptor Ligands
42. The Alkaloid Conessine and Analogues as Potent Histamine H3 Receptor Antagonists
43. Role of Rho kinase pathway in chondroitin sulfate proteoglycan‐mediated inhibition of neurite outgrowth in PC12 cells
44. Maximizing the Identification of Leads from Compound Mixtures
45. Utility of Large-Scale Transiently Transfected Cells for Cell-Based High-Throughput Screens to Identify Transient Receptor Potential Channel A1 (TRPA1) Antagonists
46. An Offline-Addition Format for Identifying GPCR Modulators by Screening 384-Well Mixed Compounds in the FLIPR
47. Application of Micro Arrayed Compound Screening (μARCS) to Identify Inhibitors of Caspase-3
48. Structure–activity relationships of non-imidazole H3 receptor ligands. Part 1
49. Structure–Activity studies for a novel series of tricyclic dihydropyrimidines as KATP channel openers (KCOs)
50. Homogeneous Time-Resolved Fluorescence Quenching Assay (LANCE) for Caspase-3 ,
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