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Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists

Authors :
Chen, Jun
Lake, Marc R.
Sabet, Reza S.
Niforatos, Wende
Pratt, Steve D.
Cassar, Steven C.
Xu, Jing
Gopalakrishnan, Sujatha
Pereda-Lopez, Ana
Gopalakrishnan, Murali
Holzman, Thomas F.
Moreland, Robert B.
Walter, Karl A.
Faltynek, Connie R.
Warrior, Usha
Scott, Victoria E.
Source :
Journal of Biomolecular Screening. February 2007, Vol. 12 Issue 1, p61, 9 p.
Publication Year :
2007

Abstract

Despite increasing use of cell-based assays in high-throughput screening (HTS) and lead optimization, one challenge is the adequate supply of high-quality cells expressing the target of interest. To this end, [...]

Details

Language :
English
ISSN :
10870571
Volume :
12
Issue :
1
Database :
Gale General OneFile
Journal :
Journal of Biomolecular Screening
Publication Type :
Academic Journal
Accession number :
edsgcl.159594233