691 results on '"Goldie, S"'
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2. Exploring Trust in Research Among Black American Men at a Health Promotion Symposium in Rural North Carolina
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Lloyd, Shawnta L., Williams, Kelvin Lamonte, and Byrd, Goldie S.
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- 2024
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3. Building a Community Partnership for the Development of Health Ministries Within the African American Community: The Triad Pastors Network
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Gwathmey, TanYa M., Williams, K. Lamonte, Caban-Holt, Allison, Starks, Takiyah D., Foy, Capri G., Mathews, Allison, and Byrd, Goldie S.
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- 2024
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4. Assessing the Role of Trust in Public Health Agencies and COVID-19 Vaccination Status Among a Community Sample of African Americans in North Carolina
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Lloyd, Shawnta L., Foy, Capri G., Caban-Holt, Allison, Gwathmey, TanYa, Williams, Kelvin Lamonte, Starks, Takiyah D., Mathews, Allison, Vines, Anissa I., Richmond, Alan, and Byrd, Goldie S.
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- 2024
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5. The Black Men's Health Forum: Improving Health Knowledge and Willingness to Participate in Research
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Shawnta L. Lloyd, Kelvin L. Williams, Allison Caban-Holt, Suzanne Craft, Laura D. Baker, and Goldie S. Byrd
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The Black Men's Health Forum, a 6-week online health education intervention for African American men and accountability partners of African American men, was conducted to increase awareness of health issues that disproportionately affect African American men. In this article, we describe the intervention and report on the immediate benefits of the intervention, including changes in health knowledge and perception of research participation. Participants completed a pre-evaluation prior to participating in the forum and a post-evaluation after each session to capture data on sociodemographic information, medical history, health knowledge, and health behaviors. A total of 60 participants (30 African American men and 30 accountability partners) completed the forum. African American men had a mean age of 61.1 years while accountability partners had a mean age of 57.6 years. Overall health knowledge increased by 6.9 points for African American men and 2.8 points for accountability partners. Before the forum began, nine African American men reported ever participating in a research study. The proportion of African American men who reported that they would definitely participate in research in the next 12 months after participating in the forum increased by 40%. Through culturally tailored programming, the Black Men's Health Forum increased access to health information as well as African American male medical professionals and health researchers for African American men in the community. Exposure to health information resulted in significant increases in health knowledge and willingness to participate in health research among African American men. [This article was written with the Triad Pastors Network.]
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- 2024
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6. Generation of an induced pluripotent stem cell line (UMi043-A) from an African American patient with Alzheimer’s disease carrying an ABCA7 deletion (p.Arg578Alafs)
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Holly N. Cukier, Shaina A. Simon, Eugene Tang, Charles G. Golightly, Mayra Juliana Laverde-Paz, Larry Deon Adams, Takiyah D. Starks, Jeffery M. Vance, Michael L. Cuccaro, Jonathan L. Haines, Goldie S. Byrd, Margaret A. Pericak-Vance, and Derek M. Dykxhoorn
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Biology (General) ,QH301-705.5 - Abstract
The ATP-binding cassette, subfamily A (ABC1), member 7 (ABCA7) gene is associated with Alzheimer’s disease (AD) risk in populations of African, Asian, and European ancestry1-5. Numerous ABCA7 mutations contributing to risk have been identified, including a 44 base pair deletion (rs142076058) specific to individuals of African ancestry and predicted to cause a frameshift mutation (p.Arg578Alafs) (Cukier et al., 2016). The UMi043-A human induced pluripotent stem cell line was derived from an African American individual with AD who is heterozygous for this deletion and is a resource to further investigate ABCA7 and how this African-specific deletion may influence disease pathology.
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- 2024
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7. Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer’s Disease in individuals of African Ancestry
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Nuytemans, Karen, Rajabli, Farid, Jean-Francois, Melissa, Kurup, Jiji Thulaseedhara, Adams, Larry D., Starks, Takiyah D., Whitehead, Patrice L., Kunkle, Brian W., Caban-Holt, Allison, Haines, Jonathan L., Cuccaro, Michael L., Vance, Jeffery M., Byrd, Goldie S., Beecham, Gary W., Reitz, Christiane, and Pericak-Vance, Margaret A.
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- 2024
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8. Perspective on the “African American participation in Alzheimer disease research: Effective strategies” workshop, 2018
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Denny, Andrea, Streitz, Marissa, Stock, Kristin, Balls‐Berry, Joyce E, Barnes, Lisa L, Byrd, Goldie S, Croff, Raina, Gao, Sujuan, Glover, Crystal M, Hendrie, Hugh C, Hu, William T, Manly, Jennifer J, Moulder, Krista L, Stark, Susan, Thomas, Stephen B, Whitmer, Rachel, Wong, Roger, Morris, John C, and Lingler, Jennifer H
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Brain Disorders ,Acquired Cognitive Impairment ,Neurosciences ,Aging ,Alzheimer's Disease ,Dementia ,Neurodegenerative ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Black or African American ,Aged ,Alzheimer Disease ,Clinical Trials as Topic ,Female ,Humans ,Male ,Patient Selection ,United States ,African American ,Alzheimer disease ,disparities ,racial differences ,recruitment ,recruitment strategies ,Clinical Sciences ,Geriatrics - Abstract
The Washington University School of Medicine Knight Alzheimer Disease Research Center's "African American Participation in Alzheimer Disease Research: Effective Strategies" Workshop convened to address a major limitation of the ongoing scientific progress regarding Alzheimer's disease and related dementias (ADRD): participants in most ADRD research programs overwhelmingly have been limited to non-Hispanic white persons, thus precluding knowledge as to how ADRD may be represented in non-white individuals. Factors that may contribute to successful recruitment and retention of African Americans into ADRD research were discussed and organized into actionable next steps as described within this report.
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- 2020
9. African Ancestry Individuals with Higher Educational Attainment Are Resilient to Alzheimer’s Disease Measured by pTau181
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Rajabli, Farid, primary, Seixas, Azizi A., additional, Akgun, Bilcag, additional, Adams, Larry D., additional, Inciute, Jovita, additional, Hamilton, Kara L., additional, Whithead, Patrice G., additional, Konidari, Ioanna, additional, Gu, Tianjie, additional, Arvizu, Jamie, additional, Golightly, Charles G., additional, Starks, Takiyah D., additional, Laux, Renee, additional, Byrd, Goldie S., additional, Haines, Jonathan L., additional, Beecham, Gary W., additional, Griswold, Anthony J., additional, Vance, Jeffery M., additional, Cuccaro, Michael L., additional, and Pericak-Vance, Margaret A., additional
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- 2024
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10. Transethnic genome‐wide scan identifies novel Alzheimer's disease loci
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Jun, Gyungah R, Chung, Jaeyoon, Mez, Jesse, Barber, Robert, Beecham, Gary W, Bennett, David A, Buxbaum, Joseph D, Byrd, Goldie S, Carrasquillo, Minerva M, Crane, Paul K, Cruchaga, Carlos, De Jager, Philip, Ertekin‐Taner, Nilufer, Evans, Denis, Fallin, M Danielle, Foroud, Tatiana M, Friedland, Robert P, Goate, Alison M, Graff‐Radford, Neill R, Hendrie, Hugh, Hall, Kathleen S, Hamilton‐Nelson, Kara L, Inzelberg, Rivka, Kamboh, M Ilyas, Kauwe, John SK, Kukull, Walter A, Kunkle, Brian W, Kuwano, Ryozo, Larson, Eric B, Logue, Mark W, Manly, Jennifer J, Martin, Eden R, Montine, Thomas J, Mukherjee, Shubhabrata, Naj, Adam, Reiman, Eric M, Reitz, Christiane, Sherva, Richard, St. George‐Hyslop, Peter H, Thornton, Timothy, Younkin, Steven G, Vardarajan, Badri N, Wang, Li‐San, Wendlund, Jens R, Winslow, Ashley R, Adams, Perrie M, Albert, Marilyn S, Albin, Roger L, Apostolova, Liana G, Arnold, Steven E, Asthana, Sanjay, Atwood, Craig S, Barmada, Michjael M, Barnes, Lisa L, Beach, Thomas G, Becker, James T, Bigio, Eileen H, Bird, Thomas D, Blacker, Deborah, Boeve, Bradley F, Bowen, James D, Boxer, Adam, Burke, James R, Cairns, Nigel J, Cao, Chuanhai, Carlson, Chris S, Carlsson, Cynthia M, Carney, Regina M, Carroll, Steven L, Chui, Helena C, Clark, David G, Corneveaux, Jason, Cribbs, David H, Crocco, Elizabeth A, De Jager, Philip L, DeCarli, Charles, DeKosky, Steven T, Demirci, F Yesim, Dick, Malcolm, Dickson, Dennis W, Doody, Rachelle S, Duara, Ranjan, Faber, Kelley M, Fairchild, Thomas J, Fallon, Kenneth B, Farlow, Martin R, Ferris, Steven, Frosch, Matthew P, Galasko, Douglas R, Gearing, Marla, Geschwind, Daniel H, Ghetti, Bernardino, Gilbert, John R, Glass, Jonathan D, Green, Robert C, and Growdon, John H
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Biomedical and Clinical Sciences ,Biological Psychology ,Clinical Sciences ,Neurosciences ,Psychology ,Neurodegenerative ,Genetics ,Dementia ,Alzheimer's Disease ,Aging ,Prevention ,Brain Disorders ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Human Genome ,Acquired Cognitive Impairment ,2.1 Biological and endogenous factors ,Aetiology ,Adaptor Proteins ,Signal Transducing ,Alzheimer Disease ,Apolipoprotein E4 ,GTPase-Activating Proteins ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Heparin-binding EGF-like Growth Factor ,Humans ,Membrane Glycoproteins ,Molecular Chaperones ,NFI Transcription Factors ,Peroxisomal Bifunctional Enzyme ,Polymorphism ,Single Nucleotide ,Receptors ,GABA ,Alzheimer's Disease Genetics Consortium ,APOE interaction ,Alzheimer's disease ,Genome-wide association ,Transethnic ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionGenetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.MethodsWe conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset.ResultsGenome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P
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- 2017
11. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry.
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Farid Rajabli, Gary W Beecham, Hugh C Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Sujuan Gao, Nicholas A Kushch, Marina Lipkin-Vasquez, Kara L Hamilton-Nelson, Juan I Young, Derek M Dykxhoorn, Karen Nuytemans, Brian W Kunkle, Liyong Wang, Fulai Jin, Xiaoxiao Liu, Briseida E Feliciano-Astacio, Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Genetic Consortium, Gerard D Schellenberg, Clifton L Dalgard, Anthony J Griswold, Goldie S Byrd, Christiane Reitz, Michael L Cuccaro, Jonathan L Haines, Margaret A Pericak-Vance, and Jeffery M Vance
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Genetics ,QH426-470 - Abstract
African descent populations have a lower Alzheimer disease risk from ApoE ε4 compared to other populations. Ancestry analysis showed that the difference in risk between African and European populations lies in the ancestral genomic background surrounding the ApoE locus (local ancestry). Identifying the mechanism(s) of this protection could lead to greater insight into the etiology of Alzheimer disease and more personalized therapeutic intervention. Our objective is to follow up the local ancestry finding and identify the genetic variants that drive this risk difference and result in a lower risk for developing Alzheimer disease in African ancestry populations. We performed association analyses using a logistic regression model with the ApoE ε4 allele as an interaction term and adjusted for genome-wide ancestry, age, and sex. Discovery analysis included imputed SNP data of 1,850 Alzheimer disease and 4,331 cognitively intact African American individuals. We performed replication analyses on 63 whole genome sequenced Alzheimer disease and 648 cognitively intact Ibadan individuals. Additionally, we reproduced results using whole-genome sequencing of 273 Alzheimer disease and 275 cognitively intact admixed Puerto Rican individuals. A further comparison was done with SNP imputation from an additional 8,463 Alzheimer disease and 11,365 cognitively intact non-Hispanic White individuals. We identified a significant interaction between the ApoE ε4 allele and the SNP rs10423769_A allele, (β = -0.54,SE = 0.12,p-value = 7.50x10-6) in the discovery data set, and replicated this finding in Ibadan (β = -1.32,SE = 0.52,p-value = 1.15x10-2) and Puerto Rican (β = -1.27,SE = 0.64,p-value = 4.91x10-2) individuals. The non-Hispanic Whites analyses showed an interaction trending in the "protective" direction but failing to pass a 0.05 significance threshold (β = -1.51,SE = 0.84,p-value = 7.26x10-2). The presence of the rs10423769_A allele reduces the odds ratio for Alzheimer disease risk from 7.2 for ApoE ε4/ε4 carriers lacking the A allele to 2.1 for ApoE ε4/ε4 carriers with at least one A allele. This locus is located approximately 2 mB upstream of the ApoE locus, in a large cluster of pregnancy specific beta-1 glycoproteins on chromosome 19 and lies within a long noncoding RNA, ENSG00000282943. This study identified a new African-ancestry specific locus that reduces the risk effect of ApoE ε4 for developing Alzheimer disease. The mechanism of the interaction with ApoEε4 is not known but suggests a novel mechanism for reducing the risk for ε4 carriers opening the possibility for potential ancestry-specific therapeutic intervention.
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- 2022
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12. Broadening Participation in STEM: Effective Methods, Practices, and Programs. Diversity in Higher Education. Volume 22
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Wilson-Kennedy, Zakiya S., Byrd, Goldie S., Kennedy, Eugene, Frierson, Henry T., Wilson-Kennedy, Zakiya S., Byrd, Goldie S., Kennedy, Eugene, and Frierson, Henry T.
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U.S. students exit undergraduate science, technology, engineering, and mathematics programs at alarming rates. Less than 50 percent of the undergraduate students who enter STEM degree programs as aspiring freshmen complete degrees in these areas. This is especially true for minorities, whose departure from STEM degree programs is often twice the rate of others. "Broadening Participation in STEM" features chapters from developers of high impact educational practices and programs that have been effective at broadening the participation of underrepresented groups in the STEM disciplines. It explores strategies used with special populations of STEM aspirants including minority groups such as African Americans, Latino Americans, and Native Americans; persons from economically disadvantaged background; and persons with disabilities. This volume contributes to national knowledge of best practices in educating underrepresented students aspiring to STEM careers. This book provides campus-based faculty, administrators, and diversity professionals with a guide that can be used to develop programs designed to address specific student success and inclusion goals in STEM programs.
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- 2019
13. Disability Status and Voting Behavior in United States Elections in Older Men and Women: Findings from the 2020 Current Population Survey Voting and Registration Supplement.
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Foy, Capri G and Byrd, Goldie S
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OLDER people ,POSTAL voting ,ABSENTEE voting ,VOTING Rights Act of 1965 (U.S.) ,ASSOCIATE degree education ,VOTER turnout ,MARITAL status ,MARRIED women ,WIDOWS - Abstract
The article explores the association between disability status and voting behavior in older adults in the United States, focusing on the 2020 election. It highlights the challenges faced by persons with disabilities in exercising their right to vote and the persistent voting gap between those with and without disabilities. The study found that individuals with disabilities were less likely to have voted, with a stronger association in women than in men. The findings suggest the need for targeted strategies to enhance voting rates among older adults with disabilities and emphasize the importance of examining factors influencing voting behavior. [Extracted from the article]
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- 2024
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14. Faculty Motivation for Scholarly Teaching and Innovative Classroom Practice—An Empirical Study
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Wilson-Kennedy, Zakiya S., Huang, Liuli, Kennedy, Eugene, Tang, Guoqing, Kanipes, Margaret I., Byrd, Goldie S., Schultz, Madeleine, editor, Schmid, Siegbert, editor, and Lawrie, Gwendolyn A., editor
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- 2019
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15. Attitudes and Perceptions about Brain Donation Among African Americans: Implications for Recruitment into Alzheimer’s Disease Research
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Caban-Holt, Allison, primary, Cuccaro, Michael L., additional, Lloyd, Shawnta L., additional, Starks, Takiyah D., additional, Adams, Larry D., additional, Ford, Tayla, additional, Haines, Jonathan L., additional, Beecham, Gary, additional, Reitz, Christiane, additional, Vance, Jeffery M., additional, Pericak-Vance, Margaret A., additional, and Byrd, Goldie S., additional
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- 2024
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16. ABCA7 frameshift deletion associated with Alzheimer disease in African Americans
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Cukier, Holly N, Kunkle, Brian W, Vardarajan, Badri N, Rolati, Sophie, Hamilton-Nelson, Kara L, Kohli, Martin A, Whitehead, Patrice L, Dombroski, Beth A, Van Booven, Derek, Lang, Rosalyn, Dykxhoorn, Derek M, Farrer, Lindsay A, Cuccaro, Michael L, Vance, Jeffery M, Gilbert, John R, Beecham, Gary W, Martin, Eden R, Carney, Regina M, Mayeux, Richard, Schellenberg, Gerard D, Byrd, Goldie S, Haines, Jonathan L, Pericak-Vance, Margaret A, Albert, Marilyn S, Albin, Roger L, Apostolova, Liana G, Arnold, Steven E, Asthana, Sanjay, Atwood, Craig S, Baldwin, Clinton T, Barmada, M Michael, Barnes, Lisa L, Barral, Sandra, Beach, Thomas G, Becker, James T, Beekly, Duane, Bennett, David A, Bigio, Eileen H, Bird, Thomas D, Blacker, Deborah, Boeve, Bradley F, Boxer, Adam, Burke, James R, Burns, Jeffrey M, Buxbaum, Joseph D, Cai, Guiqing, Cairns, Nigel J, Cantwell, Laura B, Cao, Chuanhai, Carlsson, Cynthia M, Carrasquillo, Minerva M, Carroll, Steven L, Chui, Helena C, Clark, David G, Cribbs, David H, Crocco, Elizabeth A, Cruchaga, Carlos, De Jager, Philip L, DeCarli, Charles, Demirci, F Yesim, Dick, Malcolm, Dickson, Dennis W, Duara, Ranjan, Ertekin-Taner, Nilufer, Evans, Denis A, Faber, Kelley M, Fallin, M Daniele, Fallon, Kenneth B, Fardo, David W, Farlow, Martin R, Ferris, Steven, Foroud, Tatiana M, Frosch, Matthew P, Galasko, Douglas R, Gearing, Marla, Geschwind, Daniel H, Ghetti, Bernardino, Go, Rodney CP, Goate, Alison M, Graff-Radford, Neill R, Green, Robert C, Griffith, Patrick, Growdon, John H, Hakonarson, Hakon, Hamilton, Ronald L, Haroutunian, Vahram, Harrell, Lindy E, Honig, Lawrence S, Huebinger, Ryan M, Hulette, Christine M, Hyman, Bradley T, Jicha, Gregory A, and Jin, Lee-Way
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Biological Sciences ,Genetics ,Human Genome ,Neurodegenerative ,Neurosciences ,Dementia ,Aging ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Acquired Cognitive Impairment ,Alzheimer's Disease ,Clinical Research ,Brain Disorders ,2.1 Biological and endogenous factors ,Aetiology ,Alzheimer's Disease Genetics Consortium ,Clinical sciences - Abstract
ObjectiveTo identify a causative variant(s) that may contribute to Alzheimer disease (AD) in African Americans (AA) in the ATP-binding cassette, subfamily A (ABC1), member 7 (ABCA7) gene, a known risk factor for late-onset AD.MethodsCustom capture sequencing was performed on ∼150 kb encompassing ABCA7 in 40 AA cases and 37 AA controls carrying the AA risk allele (rs115550680). Association testing was performed for an ABCA7 deletion identified in large AA data sets (discovery n = 1,068; replication n = 1,749) and whole exome sequencing of Caribbean Hispanic (CH) AD families.ResultsA 44-base pair deletion (rs142076058) was identified in all 77 risk genotype carriers, which shows that the deletion is in high linkage disequilibrium with the risk allele. The deletion was assessed in a large data set (531 cases and 527 controls) and, after adjustments for age, sex, and APOE status, was significantly associated with disease (p = 0.0002, odds ratio [OR] = 2.13 [95% confidence interval (CI): 1.42-3.20]). An independent data set replicated the association (447 cases and 880 controls, p = 0.0117, OR = 1.65 [95% CI: 1.12-2.44]), and joint analysis increased the significance (p = 1.414 × 10(-5), OR = 1.81 [95% CI: 1.38-2.37]). The deletion is common in AA cases (15.2%) and AA controls (9.74%), but in only 0.12% of our non-Hispanic white cohort. Whole exome sequencing of multiplex, CH families identified the deletion cosegregating with disease in a large sibship. The deleted allele produces a stable, detectable RNA strand and is predicted to result in a frameshift mutation (p.Arg578Alafs) that could interfere with protein function.ConclusionsThis common ABCA7 deletion could represent an ethnic-specific pathogenic alteration in AD.
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- 2016
17. Tau and Amyloid Plasma Biomarker Analysis in Alzheimer’s Disease Cohorts from Diverse Genetic Ancestries
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Griswold, Anthony J., primary, Rajabli, Farid, additional, Gu, Tianjie, additional, Garcia‐Serje, Catherine, additional, Arvizu, Jamie, additional, Golightly, Charles G., additional, Whitehead, Patrice, additional, Hamilton‐Nelson, Kara L., additional, Adams, Larry D., additional, Celis, Katrina, additional, Sanchez, Jose Javier, additional, Tejada, Sergio J., additional, Mena, Pedro R., additional, Starks, Takiyah D., additional, Cornejo‐Olivas, Mario, additional, Illanes‐Manrique, Maryenela Z, additional, Silva‐Vergara, Concepcion, additional, Cuccaro, Michael L., additional, Vance, Jeffery M., additional, Feliciano‐Astacio, Briseida E., additional, Byrd, Goldie S., additional, Beecham, Gary W., additional, Haines, Jonathan L., additional, and Pericak‐Vance, Margaret A., additional
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- 2023
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18. Genomic editing of APOE4/4 to APOE3/3 in iPSCs bearing African or European local ancestry surrounding APOE
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Oron, Oded, primary, DeRosa, Brooke A., additional, Rajabli, Farid, additional, Celis, Katrina, additional, Feliciano‐Astacio, Briseida E., additional, Silva‐Vergara, Concepcion, additional, Beecham, Gary W., additional, Adams, Larry D., additional, Tejada, Sergio J., additional, Mena, Pedro R., additional, Whitehead, Patrice, additional, Hamilton‐Nelson, Kara L., additional, Starks, Takiyah D., additional, Byrd, Goldie S., additional, Cuccaro, Michael L., additional, Young, Juan I., additional, Pericak‐Vance, Margaret A., additional, Vance, Jeffery M., additional, and Dykxhoorn, Derek M., additional
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- 2023
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19. Deciphering the Genomic Regulatory Architecture of iPSC Derived Oligodendrocytes from Diverse Ancestries for Alzheimer’s Disease Studies
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Ramirez, Aura M, primary, Shepherd, Jihanne J, additional, Coombs, Lauren, additional, Simon, Shaina A., additional, Moura, Sofia, additional, Rajabli, Farid, additional, DeRosa, Brooke A., additional, Muniz, Maria, additional, Whitehead, Patrice, additional, Adams, Larry D., additional, Mena, Pedro R., additional, Illanes‐Manrique, Maryenela Z, additional, Starks, Takiyah D., additional, Tejada, Sergio J., additional, Byrd, Goldie S., additional, Cornejo‐Olivas, Mario, additional, Feliciano‐Astacio, Briseida E., additional, Rissman, Robert A, additional, Wang, Liyong, additional, Xu, Wanying, additional, Jin, Fulai, additional, Griswold, Anthony J., additional, Young, Juan I., additional, Dykxhoorn, Derek M., additional, and Vance, Jeffery M., additional
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- 2023
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20. Maya Angelou Center for Health Equity Caregiver College: a culturally‐relevant training for African American Alzheimer’s disease caregivers
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Caban‐Holt, Allison M, primary, Starks, Takiyah D., additional, Lloyd, Shawnta', additional, Ford, Anita, additional, McCall, Sole', additional, Eale, Samuela B., additional, Fuller, Lori, additional, and Byrd, Goldie S., additional
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- 2023
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21. Uncovering the Role of an ABCA7 Frameshift Deletion in African American Alzheimer’s Disease Cellular Pathology
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DeRosa, Brooke A., primary, Nam, Younji, additional, Golightly, Charles G., additional, Simon, Shaina A., additional, Arvizu, Jamie, additional, Adams, Larry D., additional, Starks, Takiyah D., additional, Laverde‐Paz, Juliana, additional, Cukier, Holly N., additional, Vance, Jeffery M., additional, Cuccaro, Michael L., additional, Haines, Jonathan L., additional, Byrd, Goldie S., additional, Beecham, Gary W., additional, Pericak‐Vance, Margaret A., additional, and Dykxhoorn, Derek M., additional
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- 2023
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22. Perceptions of Brain donation and Medical Research Among African American Individuals: Implications for Recruitment and Retention into Alzheimer’s Research
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Starks, Takiyah D., primary, Caban‐Holt, Allison M, additional, Cuccaro, Michael L., additional, Ford, Tayla, additional, Lloyd, Shawnta', additional, Adams, Larry D., additional, Haines, Johnathan L, additional, Reitz, Christiane, additional, Vance, Jeffery M., additional, Pericak‐Vance, Margaret A., additional, and Byrd, Goldie S., additional
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- 2023
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23. Recruitment and Retention for Alzheimer’s Disease Diversity Genetic Cohorts in the ADSP (READD‐ADSP)
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Byrd, Goldie S., primary and McInerney, Katalina, additional
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- 2023
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24. Broadening Participation in STEM: Effective Education Methods, Practices, and Programs for Women and Minorities
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Zayika Wilson-Kennedy, Goldie S. Byrd, Eugene Kennedy, Henry T. Frierson, Zayika Wilson-Kennedy, Goldie S. Byrd, Eugene Kennedy, Henry T. Frierson
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- 2019
25. Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals
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Ghani, Mahdi, Reitz, Christiane, Cheng, Rong, Vardarajan, Badri Narayan, Jun, Gyungah, Sato, Christine, Naj, Adam, Rajbhandary, Ruchita, Wang, Li-San, Valladares, Otto, Lin, Chiao-Feng, Larson, Eric B, Graff-Radford, Neill R, Evans, Denis, De Jager, Philip L, Crane, Paul K, Buxbaum, Joseph D, Murrell, Jill R, Raj, Towfique, Ertekin-Taner, Nilufer, Logue, Mark, Baldwin, Clinton T, Green, Robert C, Barnes, Lisa L, Cantwell, Laura B, Fallin, M Daniele, Go, Rodney CP, Griffith, Patrick A, Obisesan, Thomas O, Manly, Jennifer J, Lunetta, Kathryn L, Kamboh, M Ilyas, Lopez, Oscar L, Bennett, David A, Hendrie, Hugh, Hall, Kathleen S, Goate, Alison M, Byrd, Goldie S, Kukull, Walter A, Foroud, Tatiana M, Haines, Jonathan L, Farrer, Lindsay A, Pericak-Vance, Margaret A, Lee, Joseph H, Schellenberg, Gerard D, St George-Hyslop, Peter, Mayeux, Richard, and Rogaeva, Ekaterina
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Clinical Research ,Aging ,Acquired Cognitive Impairment ,Alzheimer's Disease ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Dementia ,Brain Disorders ,Neurodegenerative ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Black or African American ,Aged ,Alzheimer Disease ,Case-Control Studies ,Chicago ,Genes ,Recessive ,Genome-Wide Association Study ,Homozygote ,Humans ,Indiana ,Polymorphism ,Single Nucleotide ,Alzheimer’s Disease Genetics Consortium - Abstract
ImportanceMutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by single-nucleotide polymorphism (SNP) arrays.ObjectiveTo evaluate the association between ROHs and AD in an African American population known to have a risk for AD up to 3 times higher than white individuals.Design, setting, and participantsCase-control study of a large African American data set previously genotyped on different genome-wide SNP arrays conducted from December 2013 to January 2015. Global and locus-based ROH measurements were analyzed using raw or imputed genotype data. We studied the raw genotypes from 2 case-control subsets grouped based on SNP array: Alzheimer's Disease Genetics Consortium data set (871 cases and 1620 control individuals) and Chicago Health and Aging Project-Indianapolis Ibadan Dementia Study data set (279 cases and 1367 control individuals). We then examined the entire data set using imputed genotypes from 1917 cases and 3858 control individuals.Main outcomes and measuresThe ROHs larger than 1 Mb, 2 Mb, or 3 Mb were investigated separately for global burden evaluation, consensus regions, and gene-based analyses.ResultsThe African American cohort had a low degree of inbreeding (F ~ 0.006). In the Alzheimer's Disease Genetics Consortium data set, we detected a significantly higher proportion of cases with ROHs greater than 2 Mb (P = .004) or greater than 3 Mb (P = .02), as well as a significant 114-kilobase consensus region on chr4q31.3 (empirical P value 2 = .04; ROHs >2 Mb). In the Chicago Health and Aging Project-Indianapolis Ibadan Dementia Study data set, we identified a significant 202-kilobase consensus region on Chr15q24.1 (empirical P value 2 = .02; ROHs >1 Mb) and a cluster of 13 significant genes on Chr3p21.31 (empirical P value 2 = .03; ROHs >3 Mb). A total of 43 of 49 nominally significant genes common for both data sets also mapped to Chr3p21.31. Analyses of imputed SNP data from the entire data set confirmed the association of AD with global ROH measurements (12.38 ROHs >1 Mb in cases vs 12.11 in controls; 2.986 Mb average size of ROHs >2 Mb in cases vs 2.889 Mb in controls; and 22% of cases with ROHs >3 Mb vs 19% of controls) and a gene-cluster on Chr3p21.31 (empirical P value 2 = .006-.04; ROHs >3 Mb). Also, we detected a significant association between AD and CLDN17 (empirical P value 2 = .01; ROHs >1 Mb), encoding a protein from the Claudin family, members of which were previously suggested as AD biomarkers.Conclusions and relevanceTo our knowledge, we discovered the first evidence of increased burden of ROHs among patients with AD from an outbred African American population, which could reflect either the cumulative effect of multiple ROHs to AD or the contribution of specific loci harboring recessive mutations and risk haplotypes in a subset of patients. Sequencing is required to uncover AD variants in these individuals.
- Published
- 2015
26. The Black Men’s Health Forum: Improving Health Knowledge and Willingness to Participate in Research
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Lloyd, Shawnta L., primary, Williams, Kelvin L., additional, Pastors Network, Triad, additional, Caban-Holt, Allison, additional, Craft, Suzanne, additional, D. Baker, Laura, additional, and Byrd, Goldie S., additional
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- 2023
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27. Neuropsychiatric features in a multi‐ethnic population with Alzheimer disease and mild cognitive impairment
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Celis, Katrina, primary, Zaman, Andrew, additional, Adams, Larry Deon, additional, Gardner, Olivia, additional, Farid, Rajabli, additional, Starks, Takiyah D., additional, Lacroix, Faina C., additional, Hamilton‐Nelson, Kara, additional, Mena, Pedro, additional, Tejada, Sergio, additional, Laux, Renee, additional, Song, Yeunjoo E., additional, Caban‐Holt, Allison, additional, Feliciano‐Astacio, Briseida, additional, Vance, Jeffery M., additional, Haines, Jonathan L., additional, Byrd, Goldie S., additional, Beecham, Gary W., additional, Pericak‐Vance, Margaret A., additional, and Cuccaro, Michael L., additional
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- 2023
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28. Trial Participation and Inclusion
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Byrd, Goldie S., Lang, Rosalyn, Cook, Sharon W., Edwards, Christopher L., Byfield, Grace E., Cummings-Vaughn, Lenise, editor, and Cruz-Oliver, Dulce M., editor
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- 2017
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29. Inclusive Research Excellence: Deconstructing the Research Enterprise to Facilitate Responsible STEM Research
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Smith-Jackson, Tonya L. and Byrd, Goldie S.
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Research methods -- Analysis ,University research -- Analysis ,Scholarly publishing -- Analysis ,Cognition ,Philosophy ,Education - Abstract
Research is formalized curiosity. It is poking and prying with a purpose. --Zora Neale Hurston Knowledge can be transformed by shifting paradigms and philosophies, evolving disciplines and practices, emerging data [...]
- Published
- 2019
30. Assessing Gender Differences on the Impact of COVID-19 on the Medical and Social Needs of Dementia Caregivers
- Author
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Lloyd, Shawnta L., primary, Caban-Holt, Allison, additional, Starks, Takiyah D., additional, Clark, Jarrel C., additional, and Byrd, Goldie S., additional
- Published
- 2023
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31. Gender, Age and COVID-19 Vaccination Status in African American Adult Faith-Based Congregants in the Southeastern United States
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Foy, Capri G., primary, Lloyd, Shawnta L., additional, Williams, Kelvin L., additional, Gwathmey, TanYa M., additional, Caban-Holt, Allison, additional, Starks, Takiyah D., additional, Fortune, Doreen R., additional, Ingram, LaDrea R., additional, and Byrd, Goldie S., additional
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- 2023
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32. A Rare Blood Malignancy in a Genetic Hematological Disorder: Polycythemia Vera (PV) in Sickle Cell Disease (SCD)
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Edwards, Christopher L., primary, Scott, Sharena, additional, Boggan, Michaela, additional, Meek, Jordan, additional, Bryson, W. Jeff, additional, McDougald, Alexandria, additional, Broadnax, Milo, additional, Barker, Camela S., additional, Miller, Jessica, additional, Sollers, John J., additional, Burford, Tanisha, additional, Livingston, Jonathan, additional, Whitworth, Elaine, additional, Byrd, Goldie S., additional, Williams, Kelvin L., additional, Eaton, Sherry, additional, Muhammad, Malik, additional, Cliette, George, additional, Jones, Dana, additional, Downey, Brianna, additional, Dietahin, Hilary T., additional, Turner, Merrell, additional, Thorpe, Roland, additional, Whitfield, Keith, additional, Parker, Debra O., additional, Robinson, Elwood, additional, Wood, Mary, additional, Railey, Kenyon, additional, Sudhakar, Shiv, additional, Cubilete, Wandy Morel, additional, and Shah, Nirmish, additional
- Published
- 2023
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33. African ancestryAPOEe4 non-carriers with higher educational attainment are resilient to Alzheimer disease pathology-specific blood biomarker pTau181
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Rajabli, Farid, primary, Seixas, Azizi A., additional, Akgun, Bilcag, additional, Adams, Larry D., additional, Inciute, Jovita, additional, Starks, Takiyah, additional, Laux, Renee, additional, Byrd, Goldie S, additional, Haines, Jonathan L, additional, Beecham, Gary W, additional, Vance, Jeffery M, additional, Cuccaro, Michael L, additional, and Pericak-Vance, Margaret A., additional
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- 2023
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34. Assessing the Role of Trust in Public Health Agencies and COVID-19 Vaccination Status Among a Community Sample of African Americans in North Carolina
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Lloyd, Shawnta L., primary, Foy, Capri G., additional, Caban-Holt, Allison, additional, Gwathmey, TanYa, additional, Williams, Kelvin Lamonte, additional, Starks, Takiyah D., additional, Mathews, Allison, additional, Vines, Anissa I., additional, Richmond, Alan, additional, and Byrd, Goldie S., additional
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- 2023
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35. Transethnic genome-wide scan identifies novel Alzheimer's disease loci
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Adams, Perrie M., Albert, Marilyn S., Albin, Roger L., Apostolova, Liana G., Arnold, Steven E., Asthana, Sanjay, Atwood, Craig S., Barmada, Michjael M., Barnes, Lisa L., Beach, Thomas G., Becker, James T., Bigio, Eileen H., Bird, Thomas D., Blacker, Deborah, Boeve, Bradley F., Bowen, James D., Boxer, Adam, Burke, James R., Cairns, Nigel J., Cao, Chuanhai, Carlson, Chris S., Carlsson, Cynthia M., Carney, Regina M., Carrasquillo, Minerva M., Carroll, Steven L., Chui, Helena C., Clark, David G., Corneveaux, Jason, Cribbs, David H., Crocco, Elizabeth A., Cruchaga, Carlos, De Jager, Philip L., DeCarli, Charles, DeKosky, Steven T., Demirci, F. Yesim, Dick, Malcolm, Dickson, Dennis W., Doody, Rachelle S., Duara, Ranjan, Ertekin-Taner, Nilufer, Faber, Kelley M., Fairchild, Thomas J., Fallon, Kenneth B., Farlow, Martin R., Ferris, Steven, Frosch, Matthew P., Galasko, Douglas R., Gearing, Marla, Geschwind, Daniel H., Ghetti, Bernardino, Gilbert, John R., Glass, Jonathan D., Graff-Radford, Neill R., Green, Robert C., Growdon, John H., Hakonarson, Hakon, Hamilton, Ronald L., Hardy, John, Harrell, Lindy E., Head, Elizabeth, Honig, Lawrence S., Huebinger, Ryan M., Huentelman, Matthew J., Hulette, Christine M., Hyman, Bradley T., Jarvik, Gail P., Jicha, Gregory A., Jin, Lee-Way, Karydas, Anna, Kauwe, John S.K., Kaye, Jeffrey A., Kim, Ronald, Koo, Edward H., Kowall, Neil W., Kramer, Joel H., LaFerla, Frank M., Lah, James J., Leverenz, James B., Levey, Allan I., Li, Ge, Lieberman, Andrew P., Lin, Chiao-Feng, Lopez, Oscar L., Lyketsos, Constantine G., Mack, Wendy J., Marson, Daniel C., Martiniuk, Frank, Mash, Deborah C., Masliah, Eliezer, McCormick, Wayne C., McCurry, Susan M., McDavid, Andrew N., McKee, Ann C., Mesulam, Marsel, Miller, Bruce L., Miller, Carol A., Miller, Joshua W., Morris, John C., Mukherjee, Shubhabrata, Murrell, Jill R., Myers, Amanda J., O'Bryant, Sid, Olichney, John M., Pankratz, Vernon S., Parisi, Joseph E., Partch, Amanda, Paulson, Henry L., Perry, William, Peskind, Elaine, Petersen, Ronald C., Pierce, Aimee, Poon, Wayne W., Potter, Huntington, Quinn, Joseph F., Raj, Ashok, Raskind, Murray, Reisberg, Barry, Reisch, Joan S., Reitz, Christiane, Ringman, John M., Roberson, Erik D., Rogaeva, Ekaterina, Rosen, Howard J., Rosenberg, Roger N., Royall, Donald R., Sager, Mark A., Sano, Mary, Saykin, Andrew J., Schneider, Julie A., Schneider, Lon S., Seeley, William W., Smith, Amanda G., Sonnen, Joshua A., Spina, Salvatore, Stern, Robert A., Tanzi, Rudolph E., Thornton-Wells, Tricia A., Trojanowski, John Q., Troncoso, Juan C., Tsuang, Debby W., Van Deerlin, Vivianna M., Van Eldik, Linda J., Vardarajan, Badri N., Vinters, Harry V., Vonsattel, Jean Paul, Weintraub, Sandra, Welsh-Bohmer, Kathleen A., Williamson, Jennifer, Wishnek, Sarah, Woltjer, Randall L., Wright, Clinton B., Wu, Chuang-Kuo, Yu, Chang-En, Yu, Lei, Zhang, Xiaoling, Jun, Gyungah R., Chung, Jaeyoon, Mez, Jesse, Barber, Robert, Beecham, Gary W., Bennett, David A., Buxbaum, Joseph D., Byrd, Goldie S., Crane, Paul K., De Jager, Philip, Evans, Denis, Fallin, M. Danielle, Foroud, Tatiana M., Friedland, Robert P., Goate, Alison M., Hendrie, Hugh, Hall, Kathleen S., Hamilton-Nelson, Kara L., Inzelberg, Rivka, Kamboh, M. Ilyas, Kukull, Walter A., Kunkle, Brian W., Kuwano, Ryozo, Larson, Eric B., Logue, Mark W., Manly, Jennifer J., Martin, Eden R., Montine, Thomas J., Naj, Adam, Reiman, Eric M., Sherva, Richard, St. George-Hyslop, Peter H., Thornton, Timothy, Younkin, Steven G., Wang, Li-San, Wendlund, Jens R., Winslow, Ashley R., Haines, Jonathan, Mayeux, Richard, Pericak-Vance, Margaret A., Schellenberg, Gerard, Lunetta, Kathryn L., and Farrer, Lindsay A.
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- 2017
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36. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans
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Mez, Jesse, Chung, Jaeyoon, Jun, Gyungah, Kriegel, Joshua, Bourlas, Alexandra P., Sherva, Richard, Logue, Mark W., Barnes, Lisa L., Bennett, David A., Buxbaum, Joseph D., Byrd, Goldie S., Crane, Paul K., Ertekin-Taner, Nilüfer, Evans, Denis, Fallin, M. Daniele, Foroud, Tatiana, Goate, Alison, Graff-Radford, Neill R., Hall, Kathleen S., Kamboh, M. Ilyas, Kukull, Walter A., Larson, Eric B., Manly, Jennifer J., Haines, Jonathan L., Mayeux, Richard, Pericak-Vance, Margaret A., Schellenberg, Gerard D., Lunetta, Kathryn L., and Farrer, Lindsay A.
- Published
- 2017
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37. Assessing Gender Differences on the Impact of COVID-19 on the Medical and Social Needs of Dementia Caregivers.
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Lloyd, Shawnta L., Caban-Holt, Allison, Starks, Takiyah D., Clark, Jarrel C., and Byrd, Goldie S.
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CAREGIVER attitudes ,COVID-19 ,HEALTH status indicators ,BURDEN of care ,MENTAL health ,FISHER exact test ,DEMENTIA patients ,SOCIAL isolation ,T-test (Statistics) ,DEMENTIA ,PSYCHOLOGY of caregivers ,CHI-squared test ,DESCRIPTIVE statistics ,RESEARCH funding ,NEEDS assessment ,COVID-19 testing ,PSYCHOLOGICAL adaptation ,SOCIODEMOGRAPHIC factors ,DATA analysis software ,SOCIAL case work ,PSYCHOLOGICAL distress ,DISEASE complications - Abstract
Our analyses aimed to assess health status and critical needs of caregivers of persons with dementia (PWD) during the COVID-19 pandemic by gender. Between March 2021 and August 2021, respondents (n = 267) were recruited from an Alzheimer's disease (AD) listserv at an US academic center to complete a questionnaire to capture sociodemographic data, caregiving characteristics, health status, status of COVID-19 testing, and COVID-19 preventative practices during the pandemic. Women caregivers reported needing assistance with caregiving responsibilities, whereas men caregivers needed assistance with health and social resources. More men caregivers also reported psychological distress compared to women caregivers. Our findings indicated significant differences in the resources needed and psychological distress of women and men who cared for PWD during the COVID-19 pandemic. The development of recommendations and resources with both men and women caregivers in mind may be beneficial to support informal caregivers during emergency situations. [ABSTRACT FROM AUTHOR]
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- 2024
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38. The Black Men's Health Forum: Improving Health Knowledge and Willingness to Participate in Research.
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Lloyd, Shawnta L., Williams, Kelvin L., Pastors Network, Triad, Caban-Holt, Allison, Craft, Suzanne, D. Baker, Laura, and Byrd, Goldie S.
- Abstract
The Black Men's Health Forum, a 6-week online health education intervention for African American men and accountability partners of African American men, was conducted to increase awareness of health issues that disproportionately affect African American men. In this article, we describe the intervention and report on the immediate benefits of the intervention, including changes in health knowledge and perception of research participation. Participants completed a pre-evaluation prior to participating in the forum and a post-evaluation after each session to capture data on sociodemographic information, medical history, health knowledge, and health behaviors. A total of 60 participants (30 African American men and 30 accountability partners) completed the forum. African American men had a mean age of 61.1 years while accountability partners had a mean age of 57.6 years. Overall health knowledge increased by 6.9 points for African American men and 2.8 points for accountability partners. Before the forum began, nine African American men reported ever participating in a research study. The proportion of African American men who reported that they would definitely participate in research in the next 12 months after participating in the forum increased by 40%. Through culturally tailored programming, the Black Men's Health Forum increased access to health information as well as African American male medical professionals and health researchers for African American men in the community. Exposure to health information resulted in significant increases in health knowledge and willingness to participate in health research among African American men. [ABSTRACT FROM AUTHOR]
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- 2024
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39. Leveraging African American family connectors for Alzheimer's disease genomic studies.
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Byfield, Grace, Starks, Takiyah D., Luther, Ronqeiya, Edwards, Christopher L., Lloyd, Shawnta L., Caban‐Holt, Allison, Adams, Larry Deon, Vance, Jeffery M., Cuccaro, Michael, Haines, Jonathan L., Reitz, Christiane, Pericak‐Vance, Margaret A., and Byrd, Goldie S.
- Abstract
INTRODUCTION: The underrepresentation of African Americans (AAs) in Alzheimer's disease (AD) research may limit potential benefits from translational applications. This article describes an approach to recruit AA families into an AD genomic study and characteristics of seeds (family connectors) used to overcome recruitment barriers of AA families into AD research. METHODS: A four‐step outreach and snowball sampling approach relying on family connectors was used to recruit AA families. Descriptive statistics of a profile survey were gathered to understand the demographic and health characteristics of family connectors. RESULTS: Twenty‐five AA families (117 participants) were enrolled in the study via family connectors. Most family connectors self‐identified as female (88%), were 60 years of age or older (76%), and attained post‐secondary education (77%). DISCUSSION: Community‐engaged strategies were essential to recruit AA families. Relationships between study coordinators and family connectors build trust early in the research process among AA families. Highlights: Community events were most effective for recruiting African American families.Family connectors were primarily female, in good health, and highly educated.Systematic efforts by researchers are necessary to "sell" a study to participants. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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40. Advancing STEM by Transforming Pedagogy and Institutional Teaching and Learning: The Creation of a STEM Center of Excellence for Active Learning
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Kanipes, Margaret I., primary, Tang, Guoqing, additional, Spencer-Maor, Faye E., additional, Wilson-Kennedy, Zakiya S., additional, and Byrd, Goldie S., additional
- Published
- 2019
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41. Use of local genetic ancestry to assess TOMM40-523′ and risk for Alzheimer disease
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Bussies, Parker L., Rajabli, Farid, Griswold, Anthony, Dorfsman, Daniel A., Whitehead, Patrice, Adams, Larry D., Mena, Pedro R., Cuccaro, Michael, Haines, Jonathan L., Byrd, Goldie S., Beecham, Gary W., Pericak-Vance, Margaret A., Young, Juan I., and Vance, Jeffery M.
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- 2020
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42. Recommendations for Prevention and Control of Hepatitis C Virus (HCV) Infection and HCV-Related Chronic Disease
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Alter, Miriam J., Margolis, Harold S., Bell, Beth P., Bice, Steven D., Buffington, Joanna, Chamberland, Mary, Coleman, Patrick J., Cummings, Beverley A., Dentinger, Catherine M., Garfein, Richard S., Hodgson, Wesley, Ivie, Kirsten Braatz, Kelly, Mack G., Khabbaz, Rima, Lyerla, Rob, Mahoney, Lisa D., Mast, Eric E., Moyer, Linda A., Sabin, Keith M., Shapiro, Craig N., Venczel, Linda V., Wasley, Annemarie, Williams, Ian A., Bloom, Steven C., Brittian, Monica, Clark, Kimberly A., Ivey, Diane, Quantrell, Carlisle A., Smith, Delray, Tillman, Goldie S., Gayle, Helene D., and Baker, Edward L.
- Published
- 1998
43. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations.
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Farid Rajabli, Briseida E Feliciano, Katrina Celis, Kara L Hamilton-Nelson, Patrice L Whitehead, Larry D Adams, Parker L Bussies, Clara P Manrique, Alejandra Rodriguez, Vanessa Rodriguez, Takiyah Starks, Grace E Byfield, Carolina B Sierra Lopez, Jacob L McCauley, Heriberto Acosta, Angel Chinea, Brian W Kunkle, Christiane Reitz, Lindsay A Farrer, Gerard D Schellenberg, Badri N Vardarajan, Jeffery M Vance, Michael L Cuccaro, Eden R Martin, Jonathan L Haines, Goldie S Byrd, Gary W Beecham, and Margaret A Pericak-Vance
- Subjects
Genetics ,QH426-470 - Abstract
The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The risk conferred by ε4, however, differs across populations, with populations of African ancestry showing lower ε4 risk compared to those of European or Asian ancestry. The cause of this heterogeneity in risk effect is currently unknown; it may be due to environmental or cultural factors correlated with ancestry, or it may be due to genetic variation local to the ApoE region that differs among populations. Exploring these hypotheses may lead to novel, population-specific therapeutics and risk predictions. To test these hypotheses, we analyzed ApoE genotypes and genome-wide array data in individuals from African American and Puerto Rican populations. A total of 1,766 African American and 220 Puerto Rican individuals with late-onset Alzheimer disease, and 3,730 African American and 169 Puerto Rican cognitively healthy individuals (> 65 years) participated in the study. We first assessed average ancestry across the genome ("global" ancestry) and then tested it for interaction with ApoE genotypes. Next, we assessed the ancestral background of ApoE alleles ("local" ancestry) and tested if ancestry local to ApoE influenced Alzheimer disease risk while controlling for global ancestry. Measures of global ancestry showed no interaction with ApoE risk (Puerto Rican: p-value = 0.49; African American: p-value = 0.65). Conversely, ancestry local to the ApoE region showed an interaction with the ApoE ε4 allele in both populations (Puerto Rican: p-value = 0.019; African American: p-value = 0.005). ApoE ε4 alleles on an African background conferred a lower risk than those with a European ancestral background, regardless of population (Puerto Rican: OR = 1.26 on African background, OR = 4.49 on European; African American: OR = 2.34 on African background, OR = 3.05 on European background). Factors contributing to the lower risk effect in the ApoE gene ε4 allele are likely due to ancestry-specific genetic factors near ApoE rather than non-genetic ethnic, cultural, and environmental factors.
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- 2018
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44. Leveraging African American family connectors for Alzheimer's disease genomic studies
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Grace Byfield, Takiyah D. Starks, Ronqeiya Luther, Christopher L. Edwards, Shawnta L. Lloyd, Allison Caban‐Holt, Larry Deon Adams, Jeffery M. Vance, Michael Cuccaro, Jonathan L. Haines, Christiane Reitz, Margaret A. Pericak‐Vance, and Goldie S. Byrd
- Subjects
Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2023
45. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
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Chauhan, Ganesh, Adams, Hieab H.H., Satizabal, Claudia L., Bis, Joshua C., Teumer, Alexander, Sargurupremraj, Muralidharan, Hofer, Edith, Trompet, Stella, Hilal, Saima, Smith, Albert Vernon, Jian, Xueqiu, Malik, Rainer, Traylor, Matthew, Pulit, Sara L., Amouyel, Philippe, Mazoyer, Bernard, Zhu, Yi-Cheng, Kaffashian, Sara, Schilling, Sabrina, Beecham, Gary W., Montine, Thomas J., Schellenberg, Gerard D., Kjartansson, Olafur, Guðnason, Vilmundur, Knopman, David S., Griswold, Michael E., Windham, B. Gwen, Gottesman, Rebecca F., Mosley, Thomas H., Schmidt, Reinhold, Saba, Yasaman, Schmidt, Helena, Takeuchi, Fumihiko, Yamaguchi, Shuhei, Nabika, Toru, Kato, Norihiro, Rajan, Kumar B., Aggarwal, Neelum T., De Jager, Philip L., Evans, Denis A., Psaty, Bruce M., Rotter, Jerome I., Rice, Kenneth, Lopez, Oscar L., Liao, Jiemin, Chen, Christopher, Cheng, Ching-Yu, Wong, Tien Y., Ikram, Mohammad K., van der Lee, Sven J., Amin, Najaf, Chouraki, Vincent, DeStefano, Anita L., Aparicio, Hugo J., Romero, Jose R., Maillard, Pauline, DeCarli, Charles, Wardlaw, Joanna M., Hernández, Maria del C. Valdés, Luciano, Michelle, Liewald, David, Deary, Ian J., Starr, John M., Bastin, Mark E., Muñoz Maniega, Susana, Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, Uh, Hae-Won, Lemmens, Robin, Brodaty, Henry, Wright, Margaret J., Ames, David, Boncoraglio, Giorgio B., Hopewell, Jemma C., Beecham, Ashley H., Blanton, Susan H., Wright, Clinton B., Sacco, Ralph L., Wen, Wei, Thalamuthu, Anbupalam, Armstrong, Nicola J., Chong, Elizabeth, Schofield, Peter R., Kwok, John B., van der Grond, Jeroen, Stott, David J., Ford, Ian, Jukema, J. Wouter, Vernooij, Meike W., Hofman, Albert, Uitterlinden, André G., van der Lugt, Aad, Wittfeld, Katharina, Grabe, Hans J., Hosten, Norbert, von Sarnowski, Bettina, Völker, Uwe, Levi, Christopher, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie L.M., Rosand, Jonathan, Woo, Daniel, Cole, John W., Meschia, James F., Slowik, Agnieszka, Thijs, Vincent, Lindgren, Arne, Melander, Olle, Grewal, Raji P., Rundek, Tatjana, Rexrode, Kathy, Rothwell, Peter M., Arnett, Donna K., Jern, Christina, Johnson, Julie A., Benavente, Oscar R., Wasssertheil-Smoller, Sylvia, Lee, Jin-Moo, Wong, Quenna, Mitchell, Braxton D., Rich, Stephen S., McArdle, Patrick F., Geerlings, Mirjam I., van der Graaf, Yolanda, de Bakker, Paul I.W., Asselbergs, Folkert W., Srikanth, Velandai, Thomson, Russell, McWhirter, Rebekah, Moran, Chris, Callisaya, Michele, Phan, Thanh, Rutten-Jacobs, Loes C.A., Bevan, Steve, Tzourio, Christophe, Mather, Karen A., Sachdev, Perminder S., van Duijn, Cornelia M., Worrall, Bradford B., Dichgans, Martin, Kittner, Steven J., Markus, Hugh S., Ikram, Mohammad A., Fornage, Myriam, Launer, Lenore J., Seshadri, Sudha, Longstreth, W.T., Jr, Debette, Stéphanie, Almgren, Peter, Anderson, Christopher D., Arnett, Donna K., Attia, John, Ay, Hakan, Benavente, Oscar R., Bevan, Steve, Brown, Robert D., Bustamante, Mariana, Cheng, Yu-Ching, Cole, John W., Cotlarciuc, Ioana, Cruchaga, Carlos, de Bakker, Paul IW., Delavaran, Hossein, Dichgans, Martin, Engström, Gunnar, Fornage, Myriam, Grewal, Raji P., Heitsch, Laura, Holliday, Elizabeth, Ibanez, Laure, Ilinca, Andreea, Irvin, Marguerite R., Jackson, Rebecca D., Jern, Christina, Jimenez-Conde, Jordi, Johnson, Julie A., Jood, Katarina, Kissela, Brett M., Kittner, Steven J., Kleindorfer, Dawn O., Labovitz, Daniel, Laurie, Cathy C., Lee, Jin-Moo, Lemmens, Robin, Levi, Christopher, Li, Linxin, Lindgren, Arne G., Maguire, Jane, Markus, Hugh S., McArdle, Patrick F., Melander, Olle, Meschia, James F., Mitchell, Braxton D., Müller-Nurasyid, Martina, Norrving, Bo, Peddareddygari, Leema Reddy, Pera, Joanna, Pulit, Sara L., Rexrode, Kathryn, Ribasés, Marta, Roquer, Jaume, Rost, Natalia S., Rothwell, Peter M., Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Soriano-Tárraga, Carolina, Stanne, Tara, Stauch, Konstantin, Stine, O C., Sudlow, Cathie LM., Thijs, Vincent N.S., Wasssertheil-Smoller, Sylvia, Weir, David, Williams, Stephen R., Wong, Quenna, Woo, Daniel, Worrall, Bradford B., Xu, Huichun, Seshadri, Sudha, Hyacinth, Hyacinth I, Marini, Sandro, Nyquist, Paul, Lewis, Cathryn, Hansen, Bjorn, Norrving, Bo, Rosand, Jonathan, Biffi, Alessandro, Kourkoulis, Christina, Anderson, Chris, Giese, Anne-Katrin, Sacco, Ralph, Sharma, Pankaj, Chung, Jong-Won, Kim, Gyeong-Moon, Lubitz, Steven, Bourcier, Romain, Howson, Joanna, Granata, Alessandra, Drazyk, Anna, Markus, Hugh, Wardlaw, Joanna, Mitchell, Braxton, Cole, John, Hopewell, Jemma, Walters, Robin, Turnbull, Iain, Worrall, Bradford, Bis, Josh, Reiner, Alex, Dhar, Raj, Heitsch, Laura, Lee, Jin-Moo, Prasad, Kameshwar, Sarnowski, Chloé, Aparicio, Hugo Javier, Yang, Qiong, Chasman, Daniel, Rexrode, Kathryn, Phuah, Chia-Ling, Liu, Guiyou, Elkind, Mitchell, Lange, Leslie, Rost, Natalia, James, Michael, Stewart, Jill, Vojinovic, Dina, Thijs, Vincent, Parati, Eugenio, Boncoraglio, Giorgio, Zand, Ramin, Bijlenga, Philippe, Selim, Magdy, Grond-Ginsbach, Caspar, Strbian, Daniel, Tomppo, Liisa, Sallinen, Hanne, Pfeiffer, Dorothea, Torres, Nuria, Barboza, Miguel, Laarman, Melanie, Carriero, Roberta, Holliday, Elizabeth, Jimenez-Conde, Jordi, Soriano, Carolina, Gill, Dipender, Debette, Stephanie, Mishra, Aniket, Wu, Jer-Yuarn, Ko, Tai-Ming, Bione, Silvia, Jood, Katarina, Tatlisumak, Turgut, Holmegaard, Lukas, Yue, Suo, bersano, Anna, Pera, Joanna, Slowik, Agnieszka, Levi, Christopher, Schlicht, Kristina, Lemmens, Robin, Ninomiya, Toshiharu, Oberstein, Saskia Lesnik, Lee, Tsong-Hai, Malik, Rainer, Dichgans, Martin, Lindgren, Arne, Wasselius, Johan, Drake, Mattias, Melander, Olle, Stenman, Martin, Ilinca, Andreea, Crawford, Katherine, Lena, Umme, Mateen, Farrah, Ay, Hakan, Wu, Ona, Schirmer, Markus, Cramer, Steve, Golland, Polina, Brown, Robert, Meschia, James, Ross, Owen A., Pare, Guillaume, Chong, Mike, Rundek, Tatjana, Gwinn, Katrina, Chen, Christopher, Koenig, Jim, Giralt, Eva, Saleheen, Danish, de Leeuw, Frank-Erik, Klijn, Karin, Kamatani, Yoichiro, Kubo, Michiaki, Okada, Yukinori, Pedersen, Annie, Olsson, Maja, Martín, Juan José, Xu, Huichun, Tan, Eng King, Frid, Petrea, Lee, Chaeyoung, Tregouet, David, Leung, Thomas, Choy, Richard, Jern, Christina, Loo, Keat Wei, Rinkel, Gabriel, Franca, Paulo, Cendes, Iscia, Carrera, Caty, Fernandez-Cadenas, Israel, Montaner, Joan, Kim, Helen, Owolabi, Mayowa, Sofat, Reecha, Bakker, Mark, Ruigrok, Ynte, Hauer, Allard, Pulit, Sara L., van der Laan, Sander W., Irvin, Ryan, Sargurupremraj, Murali, Pezzini, Alessandro, Abd-Allah, Foad, Liebeskind, David, Traylor, Matthew, Tan, Rhea, Danesh, John, Rutten-Jacobs, Loes, Donatti, Amanda, Avelar, Wagner, Broderick, Joseph, Woo, Daniel, Sudlow, Cathie, Rannikmae, Kristiina, McDonough, Caitrin Wheeler, van Agtmael, Tom, Walters, Matthew, Söderholm, Martin, Lorentzen, Erik, Olsson, Sandra, Stanne, Tara, Olsson, Martina, Akinyemi, Rufus, Cotlatciuc, Ioana, McArdle, Patrick, Dave, Tushar, Kittner, Steven, Attia, John, Faber, James E, Millwood, Iona, Márquez, Elsa Valdés, Mancuso, Michelangelo, Vibo, Riina, Korv, Janika, Maguire, Jane, Fornage, Myriam, Majersik, Jennifer, DeHavenon, Adam, Alexander, Matthew, Sale, Michele, Southerland, Andrew, Owens, Debra, Psaty, Bruce, Longstreth, W. T., Jr, Wolfe, Stacey Quintero, Langefeld, Carl, Cruchaga, Carlos, Konrad, Jan, Sheth, Kevin, Falcone, Guido, Donahue, Kathleen, Simpkins, Alexis N, Liang Byorn, Tan Wei, Chan, Bernard, Clatworthy, Phil, Florez, Jose, Harshfield, Eric, Hozawa, Atsushi, Hsu, Chung, Hu, Chaur-Jong, Ibanez, Laure, Ihara, Masafumi, Lange, Marcos, Lee, Soo Ji, Lee, I-Hui, Musolino, Patricia, Nakatomi, Hirofumi, Park, Kwang-Yeol, Rich, Stephen S, Riley, Chris, Sung, Joohon, Suzuki, Hideaki, Vo, Katie, Washida, Kazuo, Ibenez, Laura Garcia, Slowik, Agnieszka, Hofman, Albert, Algra, Ale, Reiner, Alex P, Doney, Alexander S F, Gschwendtner, Andreas, Ilinca, Andreea, Giese, Anne-Katrin, Lindgren, Arne, Vicente, Astrid M, Norrving, Bo, Nordestgaard, Børge G, Mitchell, Braxton D, Worrall, Bradford B, Psaty, Bruce M, Carty, Cara L, Sudlow, Cathie, Anderson, Christopher D, Levi, Christopher, Satizabal, Claudia L, Palmer, Colin N A, Gamble, Dale M, Woo, Daniel, Saleheen, Danish, Ringelstein, E Bernd, Valdimarsson, Einar, Holliday, Elizabeth, Davies, Gail, Chauhan, Ganesh, Pasterkamp, Gerard, Boncoraglio, Giorgio, Kuhlenbäumer, Gregor, Thorleifsson, Gudmar, Falcone, Guido J, Pare, Guillame, Schmidt, Helena, Delavaran, Hossein, Markus, Hugh S, Aparicio, Hugo J, Deary, Ian, Cotlarciuc, Ioana, Fernandez-Cadenas, Israel, Meschia, James, Hopewell, Jemma C, Liu, Jingmin, Montaner, Joan, Pera, Joanna, Cole, John, Attia, John R, Rosand, Jonathan, Ferro, Jose M, Bis, Joshua, Furie, Karen, Stefansson, Kari, Berger, Klaus, Kostulas, Konstantinos, Rannikmae, Kristina, Ikram, M Arfan, Benn, Marianne, Dichgans, Martin, Farrall, Martin, Pandolfo, Massimo, Traylor, Matthew, Walters, Matthew, Sale, Michele, Nalls, Mike, Fornage, Myriam, van Zuydam, Natalie R, Sharma, Pankaj, Abrantes, Patricia, de Bakker, Paul IW, Higgins, Peter, Lichtner, Peter, Rothwell, Peter M, Amouyel, Philippe, Yang, Qiong, Malik, Rainer, Schmidt, Reinhold, Clarke, Robert, Lemmens, Robin, van der Laan, Sander W, Pulit, Sara L, Abboud, Sherine, Oliveira, Sofia A, Gretarsdottir, Solveig, Debette, Stephanie, Williams, Stephen R, Bevan, Steve, Kittner, Steven J, Seshadri, Sudha, Mosley, Thomas, Battey, Thomas WK, Tatlisumak, Turgut, Thorsteinsdottir, Unnur, Thijs, Vincent NS, Longstreth, W T, Zhao, Wei, Chen, Wei-Min, Cheng, Yu-Ching, Albert, Marilyn S., Albin, Roger L., Apostolova, Liana G., Arnold, Steven E., Asthana, Sanjay, Atwood, Craig S., Baldwin, Clinton T., Barmada, M. Michael, Barnes, Lisa L., Barral, Sandra, Beach, Thomas G., Becker, James T., Beecham, Gary W., Beekly, Duane, Bennett, David A., Bigio, Eileen H., Bird, Thomas D., Blacker, Deborah, Boeve, Bradley F., Boxer, Adam, Burke, James R., Burns, Jeffrey M., Buxbaum, Joseph D., Byrd, Goldie S., Cai, Guiqing, Cairns, Nigel J., Cantwell, Laura B., Cao, Chuanhai, Carlsson, Cynthia M., Carney, Regina M., Carrasquillo, Minerva M., Carroll, Steven L., Chui, Helena C., Clark, David G., Cribbs, David H., Crocco, Elizabeth A., Cruchaga, Carlos, De Jager, Philip L., DeCarli, Charles, Demirci, F. Yesim, Dick, Malcolm, Dickson, Dennis W., Duara, Ranjan, Ertekin-Taner, Nilufer, Evans, Denis A., Faber, Kelley M., Fallin, M. Daniele, Fallon, Kenneth B., Fardo, David W., Farlow, Martin R., Farrer, Lindsay A., Ferris, Steven, Foroud, Tatiana M., Frosch, Matthew P., Galasko, Douglas R., Gearing, Marla, Geschwind, Daniel H., Ghetti, Bernardino, Gilbert, John R., Go, Rodney C.P., Goate, Alison M., Graff-Radford, Neill R., Green, Robert C., Griffith, Patrick, Growdon, John H., Haines, Jonathan L., Hakonarson, Hakon, Hamilton, Ronald L., Hamilton-Nelson, Kara L., Haroutunian, Vahram, Harrell, Lindy E., Honig, Lawrence S., Huebinger, Ryan M., Hulette, Christine M., Hyman, Bradley T., Jicha, Gregory A., Jin, Lee-Way, Jun, Gyungah, Kamboh, M. Ilyas, Karydas, Anna, Kauwe, John S.K., Kaye, Jeffrey A., Kim, Ronald, Kowall, Neil W., Kramer, Joel H., Kukull, Walter A., Kunkle, Brian W., LaFerla, Frank M., Lah, James J., Lang-Walker, Rosalyn, Larson, Eric B., Leverenz, James B., Levey, Allan I., Li, Ge, Lieberman, Andrew P., Logue, Mark W., Lopez, Oscar L., Lunetta, Kathryn L., Lyketsos, Constantine G., Mack, Wendy J., Manly, Jennifer J., Marson, Daniel C., Martin, Eden R., Martiniuk, Frank, Mash, Deborah C., Masliah, Eliezer, Mayeux, Richard, McKee, Ann C., Mesulam, Marsel, Miller, Bruce L., Miller, Carol A., Miller, Joshua W., Montine, Thomas J., Morris, John C., Murrell, Jill R., Naj, Adam C., Obisesan, Thomas O., Olichney, John M., Pankratz, Vernon S., Parisi, Joseph E., Partch, Amanda, Paulson, Henry L., Pericak-Vance, Margaret A., Perry, William, Peskind, Elaine, Petersen, Ronald C., Pierce, Aimee, Poon, Wayne W., Potter, Huntington, Quinn, Joseph F., Raj, Ashok, Raj, Towfique, Raskind, Murray, Reiman, Eric M., Reisberg, Barry, Reitz, Christiane, Ringman, John M., Roberson, Erik D., Rosen, Howard J., Rosenberg, Roger N., Sager, Mark A., Sano, Mary, Saykin, Andrew J., Schellenberg, Gerard D., Schneider, Julie A., Schneider, Lon S., Seeley, William W., Smith, Amanda G., Sonnen, Joshua A., Spina, Salvatore, Stern, Robert A., Swerdlow, Russell H., Tanzi, Rudolph E., Thornton-Wells, Tricia A., Trojanowski, John Q., Troncoso, Juan C., Tsuang, Debby W., Valladares, Otto, Van Deerlin, Vivianna M., Van Eldik, Linda J., Vardarajan, Badri N., Vinters, Harry V., Vonsattel, Jean Paul, Wang, Li-San, Weintraub, Sandra, Welsh-Bohmer, Kathleen A., Williamson, Jennifer, Wingo, Thomas S., Wishnek, Sarah, Woltjer, Randall L., Wright, Clinton B., Younkin, Steven G., Yu, Chang-En, Yu, Lei, Chauhan, Ganesh, Chu, Audrey Y., Fornage, Myriam, Bis, Joshua C., Havulinna, Aki S., Sargurupremraj, Muralidharan, Smith, Albert Vernon, Adams, Hieab H.H., Choi, Seung Hoan, Trompet, Stella, Garcia, Melissa E., Manichaikul, Ani, Teumer, Alexander, Gustafsson, Stefan, Bartz, Traci M., Bellenguez, Céline, Vidal, Jean Sebastien, Jian, Xueqiu, Kjartansson, Olafur, Wiggins, Kerri L., Satizabal, Claudia L., Xue, Flora, Ripatti, Samuli, Liu, Yongmei, Deelen, Joris, Hoed, Marcel den, Heckbert, Susan R., Rice, Kenneth, Smith, Nicholas L., Wong, Quenna, Aparicio, Hugo J., Buring, Julie E., Ridker, Paul M, Berr, Claudine, Dartigues, Jean-François, Hamsten, Anders, Magnusson, Patrik K., Pedersen, Nancy L., Lannfelt, Lars, Lind, Lars, Lindgren, Cecilia M., Morris, Andrew P., Hofman, Albert, Koudstaal, Peter J., Portegies, Marileen LP., Uitterlinden, André G., de Craen, Anton JM, Ford, Ian, Jukema, J. Wouter, Stott, David J, Allen, Norrina B., Sale, Michele M., Johnson, Andrew D, Bennett, David A., De Jager, Philip L., White, Charles C., Grabe, Hans Jörgen, Paulista Markus, Marcello Ricardo, Lopez, Oscar L, Rotter, Jerome I., Nalls, Michael A., Gottesman, Rebecca F., Griswold, Michael E., Knopman, David S., Windham, B. Gwen, Beiser, Alexa, Vartiainen, Erkki, French, Curtis R., Kurth, Tobias, Psaty, Bruce M., Harris, Tamara B., Rich, Stephen S, deStefano, Anita L., Schmidt, Carsten Oliver, Salomaa, Veikko, Mosley, Thomas H., Ingelsson, Erik, van Duijn, Cornelia M., Tzourio, Christophe, Launer, Lenore J, Ikram, M. Arfan, Chasman, Daniel I., Longstreth, W. T., Jr, Seshadri, Sudha, Debette, Stéphanie, Verhaaren, Benjamin F.J., Debette, Stéphanie, Bis, Joshua C., Smith, Jennifer A., Ikram, M. Kamran, Adams, Hieab H., Beecham, Ashley H., Rajan, Kumar B., Lopez, Lorna M., Barral, Sandra, van Buchem, Mark A., van der Grond, Jeroen, Smith, Albert V., Hegenscheid, Katrin, Aggarwal, Neelum T., de Andrade, Mariza, Atkinson, Elizabeth J., Beekman, Marian, Beiser, Alexa S., Blanton, Susan H., Boerwinkle, Eric, Brickman, Adam M., Bryan, R. Nick, Chauhan, Ganesh, Chen, Christopher P.L.H., Chouraki, Vincent, de Craen, Anton J.M., Crivello, Fabrice, Deary, Ian J., Deelen, Joris, De Jager, Philip L., Dufouil, Carole, Elkind, Mitchell S.V., Evans, Denis A., Freudenberger, Paul, Gottesman, Rebecca F., Guðnason, Vilmundur, Habes, Mohamad, Heckbert, Susan R., Heiss, Gerardo, Hilal, Saima, Hofer, Edith, Hofman, Albert, Ibrahim-Verbaas, Carla A., Knopman, David S., Lewis, Cora E., Liao, Jiemin, Liewald, David C.M., Luciano, Michelle, van der Lugt, Aad, Martinez, Oliver O., Mayeux, Richard, Mazoyer, Bernard, Nalls, Mike, Nauck, Matthias, Niessen, Wiro J., Oostra, Ben A., Psaty, Bruce M., Rice, Kenneth M., Rotter, Jerome I., von Sarnowski, Bettina, Schmidt, Helena, Schreiner, Pamela J., Schuur, Maaike, Sidney, Stephen S., Sigurdsson, Sigurdur, Slagboom, P. Eline, Stott, David J.M., van Swieten, John C., Teumer, Alexander, Töglhofer, Anna Maria, Traylor, Matthew, Trompet, Stella, Turner, Stephen T., Tzourio, Christophe, Uh, Hae-Won, Uitterlinden, André G., Vernooij, Meike W., Wang, Jing J., Wong, Tien Y., Wardlaw, Joanna M., Windham, B. Gwen, Wittfeld, Katharina, Wolf, Christiane, Wright, Clinton B., Yang, Qiong, Zhao, Wei, Zijdenbos, Alex, Jukema, J. Wouter, Sacco, Ralph L., Kardia, Sharon L.R., Amouyel, Philippe, Mosley, Thomas H., Longstreth, W. T., Jr, DeCarli, Charles C., van Duijn, Cornelia M., Schmidt, Reinhold, Launer, Lenore J., Grabe, Hans J., Seshadri, Sudha S., Ikram, M. Arfan, Fornage, Myriam, Bis, Joshua C., Kavousi, Maryam, Franceschini, Nora, Isaacs, Aaron, Abecasis, Gonçalo R, Schminke, Ulf, Post, Wendy, Smith, Albert V., Cupples, L. Adrienne, Markus, Hugh S, Schmidt, Reinhold, Huffman, Jennifer E., Lehtimäki, Terho, Baumert, Jens, Münzel, Thomas, Heckbert, Susan R., Dehghan, Abbas, North, Kari, Oostra, Ben, Bevan, Steve, Stoegerer, Eva-Maria, Hayward, Caroline, Raitakari, Olli, Meisinger, Christa, Schillert, Arne, Sanna, Serena, Völzke, Henry, Cheng, Yu-Ching, Thorsson, Bolli, Fox, Caroline S., Rice, Kenneth, Rivadeneira, Fernando, Nambi, Vijay, Halperin, Eran, Petrovic, Katja E., Peltonen, Leena, Wichmann, H. Erich, Schnabel, Renate B., Dörr, Marcus, Parsa, Afshin, Aspelund, Thor, Demissie, Serkalem, Kathiresan, Sekar, Reilly, Muredach P., Taylor, Kent, Uitterlinden, Andre, Couper, David J., Sitzer, Matthias, Kähönen, Mika, Illig, Thomas, Wild, Philipp S., Orru, Marco, Lüdemann, Jan, Shuldiner, Alan R., Eiriksdottir, Gudny, White, Charles C., Rotter, Jerome I., Hofman, Albert, Seissler, Jochen, Zeller, Tanja, Usala, Gianluca, Ernst, Florian, Launer, Lenore J., DʼAgostino, Ralph B., Sr, OʼLeary, Daniel H., Ballantyne, Christie, Thiery, Joachim, Ziegler, Andreas, Lakatta, Edward G., Chilukoti, Ravi Kumar, Harris, Tamara B., Wolf, Philip A., Psaty, Bruce M., Polak, Joseph F, Li, Xia, Rathmann, Wolfgang, Uda, Manuela, Boerwinkle, Eric, Klopp, Norman, Schmidt, Helena, Wilson, James F, Viikari, Jorma, Koenig, Wolfgang, Blankenberg, Stefan, Newman, Anne B., Witteman, Jacqueline, Heiss, Gerardo, van Duijn, Cornelia, Scuteri, Angelo, Homuth, Georg, Mitchell, Braxton D., Gudnason, Vilmundur, and O’Donnell, Christopher J.
- Published
- 2019
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46. Self‐reported experiences of discrimination and incident dementia
- Author
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Bancks, Michael P., primary, Byrd, Goldie S., additional, Caban‐Holt, Allison, additional, Fitzpatrick, Annette L., additional, Forrester, Sarah N., additional, Hayden, Kathleen M., additional, Heckbert, Susan R., additional, Kershaw, Kiarri N., additional, Rapp, Stephen R., additional, Sachs, Bonnie C., additional, and Hughes, Timothy M., additional
- Published
- 2023
- Full Text
- View/download PDF
47. Impact of the COVID‐19 Pandemic on Dementia Caregivers in the South US
- Author
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Starks, Takiyah D., primary, Lloyd, Shawnta', additional, Caban‐Holt, Allison M, additional, Clark, Jarrel, additional, and Byrd, Goldie S., additional
- Published
- 2022
- Full Text
- View/download PDF
48. Ancestral Analysis of the Presenilin‐1 G206A Variant Reveals it as a Founder Event on an African Haplotype in the Puerto Rican Population
- Author
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Hamilton‐Nelson, Kara L., primary, Griswold, Anthony J., additional, Rajabli, Farid, additional, Whitehead, Patrice L., additional, Contreras, Maricarmen, additional, Tejada, Sergio, additional, Sanchez, Jose Javier, additional, Mena, Pedro Ramon, additional, Adams, Larry D., additional, Starks, Takiyah D., additional, Silva‐Vergara, Concepcion, additional, Cuccaro, Michael L., additional, Vance, Jeffery M., additional, Byrd, Goldie S., additional, Haines, Jonathan L., additional, Beecham, Gary W., additional, Feliciano‐Astacio, Briseida E., additional, Pericak‐Vance, Margaret A., additional, and Celis, Katrina, additional
- Published
- 2022
- Full Text
- View/download PDF
49. Trusted Partnerships in the Faith Community Facilitate Awareness and Recruitment of African Americans for Alzheimer’s Disease Studies
- Author
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Williams, Kelvin, primary, Henderson, Shelby, additional, Lloyd, Shawnta', additional, Caban‐Holt, Allison M, additional, Starks, Takiyah D., additional, Martin, Patrick McPhail, additional, Bozoki, Andrea C., additional, Price, Stephen Russ, additional, Plassman, Brenda L, additional, Welsh‐Bohmer, Kathleen A., additional, and Byrd, Goldie S., additional
- Published
- 2022
- Full Text
- View/download PDF
50. Depressive Symptoms Associated with an Earlier Age at Onset Differ as a Function of Race‐Ethnicity: An Exploratory Analysis
- Author
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Zaman, Andrew, primary, Mena, Pedro Ramon, additional, Adams, Larry D., additional, Contreras, Maricarmen, additional, Lacroix, Faina C, additional, Tejada, Sergio, additional, Starks, Takiyah D., additional, Feliciano‐Astacio, Briseida E., additional, Silva, Concepcion, additional, Caban‐Holt, Allison M, additional, Byrd, Goldie S., additional, Martinez, Izri, additional, Ayodele, Temitope, additional, Baez, Penelope, additional, Blackshire, Gabrielle, additional, Kennedy, Sara, additional, Reitz, Christiane, additional, Haines, Jonathan L., additional, Vance, Jeffery M., additional, Vance, Margaret A., additional, and Cuccaro, Michael L., additional
- Published
- 2022
- Full Text
- View/download PDF
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