10 results on '"Gimenes DL"'
Search Results
2. Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil.
- Author
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Peres SV, Arantes PE, Fagundes MA, Ab'Saber AM, Gimenes DL, Curado MP, and Vieira RADC
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- Female, Humans, Prognosis, Retrospective Studies, Brazil epidemiology, Neoplasm Staging, Public Health, Breast Neoplasms diagnosis, Breast Neoplasms pathology
- Abstract
Objective: This study aimed to analyze the prognosis of women with breast cancer by molecular subtypes, sociodemographic variables, and clinical and treatment characteristics., Methods: This hospital-based retrospective cohort study analyzed 1,654 women over 18 years of age diagnosed with invasive breast cancer from 2000 to 2018. Data were extracted from Brazil's Oncocenter Foundation of São Paulo. The variables analyzed were age, histology, molecular subtypes, clinical staging, treatment type, and diagnosis-to-treatment time. Cox regression analysis was applied to estimate death risk., Results: Women with HER-2-positive (nonluminal) and triple-negative molecular subtypes were more than twice more likely to be at risk of death, with adjusted hazard ratio - HRadj=2.30 (95% confidence interval - 95%CI 1.34-3.94) and HRadj=2.51 (95%CI 1.61-3.92), respectively. A delayed treatment associated with an advanced clinical stage at diagnosis increased fourfold the risk of death (HRadj=4.20 (95%CI 2.36-7.49)., Conclusion: In summary, besides that interaction between advanced clinical stage and longer time between diagnosis and treatment, HER-2-positive (nonluminal) and triple-negative phenotypes were associated with a worse prognosis. Therefore, actions to reduce barriers in diagnosis and treatment can provide better outcome, even in aggressive phenotypes.
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- 2023
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3. Characteristics and prognosis of stage I-III breast cancer subtypes in Brazil: The AMAZONA retrospective cohort study.
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Simon SD, Bines J, Werutsky G, Nunes JS, Pacheco FC, Segalla JG, Gomes AJS, Adam Van Eyll BMHR, Gimenes DL, Crocamo S, Freitas-Junior R, Lago LD, Queiroz GS, Jobim de Azevedo S, Rosa DD, Delgado G, Borges GS, Verônica do Nascimento Y, Zaffaroni F, Martínez-Mesa J, and Barrios CHE
- Subjects
- Adult, Brazil, Chemotherapy, Adjuvant, Disease-Free Survival, Female, Follow-Up Studies, Humans, Mastectomy statistics & numerical data, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, Prognosis, Retrospective Studies, Triple Negative Breast Neoplasms classification, Triple Negative Breast Neoplasms pathology, Young Adult, Breast Neoplasms classification, Breast Neoplasms pathology
- Abstract
Objective: To describe stage I-III breast cancer (BC) molecular subtypes and outcomes among a cohort of patients from Brazil., Methods: AMAZONA study is a retrospective cohort conducted from June 2008 to January 2009 including women of at least 18 years old, with histologically proven breast cancer, diagnosed in 2001 (n = 2198) and 2006 (n = 2714). In this analysis, we included patients who underwent surgery, had stage I-III disease and available pathological information (n = 2296). We estimated molecular subtypes by local immunohistochemical stains. Data was obtained from medical charts and public databases., Results: Mean age at diagnosis was 54 years and 41.1% were younger than 50 years. 23.3% were diagnosed in stage I, 53.5% in stage II and 23.2% in stage III. 80.8% were treated in the public health system. 71.3% had hormonal receptor positive disease, 15.7% were HER-2 positive and 21.1% had triple-negative breast cancer. 55.6% were treated with mastectomy and 96.2% received adjuvant treatment (82.2% chemotherapy). 13.4% of HER-2 positive patients received adjuvant trastuzumab. Overall survival rate at 5 years was 96.84% for stage I, 94.16% for stage II and 70.48% for stage III. Molecular subtypes were independent prognostic factor in stages II and III patients., Conclusions: Brazilian women have a higher risk of being diagnosed with late stage breast cancer and younger age than in high-income countries. Luminal-like disease is the most common molecular subtype in the country. Triple negative and HER-2 positive had the worst prognosis., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2019
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4. Meningeal carcinomatosis in solid tumors.
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Martins SJ, Azevedo CR, Chinen LT, Cruz MR, Peterlevitz MA, and Gimenes DL
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- Humans, Meningeal Carcinomatosis secondary, Prognosis, Meningeal Carcinomatosis diagnosis, Meningeal Carcinomatosis therapy
- Abstract
The involvement of the leptomeninges by metastatic tumors can be observed in solid tumors, in which case it is termed meningeal carcinomatosis (MC), and in lymphoproliferative malignant disease. It is more common in breast and lung cancer, as well as melanoma, with adenocarcinoma being the most frequent histological type. MC is usually a late event, with disseminated and progressive disease already present and, it is characterized by multifocal neurological signs and symptoms. Diagnosis is based on the evaluation of clinical presentation, cerebrospinal fluid and neuroimaging studies. The better systemic disease control is observed with new therapeutic agents, and the development of neuroimaging methods is responsible for the increasing incidence of such metastatic evolution. Intrathecal chemotherapy is generally the treatment of choice, although frequently palliative. Prognosis is guarded, although a higher performance status may indicate a subgroup of patients with a more favorable outcome.
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- 2011
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5. Meningeal carcinomatosis in breast cancer: prognostic factors and outcome.
- Author
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de Azevedo CR, Cruz MR, Chinen LT, Peres SV, Peterlevitz MA, de Azevedo Pereira AE, Fanelli MF, and Gimenes DL
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- Adult, Aged, Antineoplastic Agents therapeutic use, Breast Neoplasms mortality, Breast Neoplasms therapy, Carcinoma, Ductal, Breast mortality, Carcinoma, Ductal, Breast therapy, Combined Modality Therapy, Female, Humans, Kaplan-Meier Estimate, Meningeal Carcinomatosis mortality, Meningeal Carcinomatosis therapy, Middle Aged, Neoplasm Staging, Prognosis, Radiotherapy, Treatment Outcome, Breast Neoplasms pathology, Carcinoma, Ductal, Breast pathology, Meningeal Carcinomatosis secondary
- Abstract
Meningeal carcinomatosis (MC) occurs in up to 5% of breast cancer patients. Few studies have evaluated prognostic markers in breast cancer patients with MC. Our aim was to describe the treatment of breast cancer patients with MC, and identify prognostic factors related to survival. Sixty breast cancer patients that had a diagnosis of MC between January 2003 and December 2009 were included. The median age was 46 years (range 27-76). Most patients had invasive ductal carcinoma (78.3%) and high histological/nuclear grade (61.7/53.3%). Estrogen and progesterone receptors were positive in 51.7 and 43.3% of patients, respectively, and 15% were HER-2-positive. Symptoms at presentation were headache, cranial nerve dysfunction, seizures, and intracranial hypertension signals. Diagnosis was made by CSF cytology in 66.7% of cases and by MRI in 71.7%. Intrathecal (IT) chemotherapy was used in 68.3% of patients, and 21.6% received a new systemic treatment (chemo- or hormone therapy). Median survival was 3.3 months (range 0.03-90.4). There was no survival difference according to age, nuclear grade, hormonal and HER-2 status, CSF features, sites of metastasis, systemic and IT chemotherapy, or radiotherapy. However, histological grade and performance status had a significant impact on survival in the multivariate analysis. Only four papers have addressed prognostic factors in breast cancer patients with MC in the last two decades. The results of those reports are discussed here. High histological grade and poor performance status seem to impact survival of breast cancer patients with MC. Prospective studies are necessary to clarify the role of IT and systemic treatment in the treatment of those patients.
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- 2011
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6. Prolonged time to progression with fulvestrant for metastatic breast cancer.
- Author
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Mello CA, Chinen LT, da Silva SC, do Nascimento Matias C, Benevides CF, Gimenes DL, and Fanelli MF
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- Breast Neoplasms genetics, Breast Neoplasms pathology, Cohort Studies, Disease Progression, Disease-Free Survival, Estradiol therapeutic use, Female, Fulvestrant, Genes, erbB-2, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Receptors, Estrogen biosynthesis, Receptors, Estrogen genetics, Receptors, Progesterone biosynthesis, Receptors, Progesterone genetics, Retrospective Studies, Antineoplastic Agents, Hormonal therapeutic use, Breast Neoplasms drug therapy, Estradiol analogs & derivatives
- Abstract
Although the incidence of breast cancer has been declining in recent years, the disease is still one of the leading causes of cancer deaths in women. Recently, breast cancer has been treated with innovative approaches that use hormone-sensitive therapies. This is because in at least one-third of breast cancers, estrogens mediated via the estrogen receptor pathway act as endocrine growth factors. Fulvestrant has been studied as both first- and second-line therapy for locally advanced and metastatic breast cancer, but few studies have shown its effect as third-line therapy alone. To observe the disease time to progression (TTP) obtained with fulvestrant when used on metastatic breast cancer as first-, second-, and also third-line therapy. We also aimed to correlate the TTP obtained with fulvestrant with hormone receptor, HER2 expression, and metastatic site. This was a cohort study that retrospectively examined medical records of 73 postmenopausal women with advanced breast cancer who were treated with fulvestrant (250 mg/month i.m. injection) and followed at the Department of Medical Oncology at Hospital do Cancer A. C. Camargo in São Paulo, Brazil from August 2003 to December 2006. The median TTP with fulvestrant was about 11 months. When used as the first-line therapy, TTP was about 13 months; when used as second-line, TTP was about 6 months; and when used as third-line, it was about 12 months. No statistically significant difference was observed regarding the therapy line. In patients with positive ER tumors, TTP was 11 months. No significant difference in TTP was observed in negative ER tumors (TTP = 10 months). In patients with positive PgR tumors, TTP was 13 months and for negative PgR, TTP was 6 months (P = 0.008). According to the HER2 status, the TTP was 5 months for HER2+ and 10 months for HER2-. Our findings indicate that fulvestrant is an effective alternative for treatment of metastatic breast cancer.
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- 2011
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7. Fertility preservation in women with breast cancer undergoing adjuvant chemotherapy: a systematic review.
- Author
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Cruz MR, Prestes JC, Gimenes DL, and Fanelli MF
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- Animals, Breast Neoplasms complications, Breast Neoplasms physiopathology, Female, Fertility physiology, Gonadotropin-Releasing Hormone agonists, Gonadotropin-Releasing Hormone physiology, Humans, Infertility, Female complications, Breast Neoplasms drug therapy, Chemotherapy, Adjuvant adverse effects, Fertility drug effects, Infertility, Female chemically induced, Infertility, Female prevention & control
- Abstract
Objective: To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer., Design: Systematic review of literature., Setting: Academic Department of Medical Oncology., Patient(s): Premenopausal women exposed to adjuvant chemotherapy for breast cancer., Main Outcome Measure(s): Fertility preservation., Result(s): Data for fertility preservation in this setting come from nonrandomized trials and observational studies. The main methods of fertility preservation are ovarian protection by gonadotropin-releasing hormone (GnRH) agonists, cryopreservation of embryos after in vitro fertilization, and preservation of operatively sampled ovarian tissue or eggs after stimulation and puncture. Ongoing trials are assessing the role of ovarian protection by GnRH agonists., Conclusion(s): At present, there are no high-level, evidence-based recommendations for preservation of fertility or of ovarian function in women with breast cancer. This is an important issue for young breast cancer survivors, and further studies are needed. Moreover, the interplay between ovarian protection by GnRH agonists and the efficacy of adjuvant chemotherapy remains elusive., (Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Published
- 2010
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8. Predictors of peritoneal carcinomatosis in patients with gastric cancer treated at a single institution in Brazil.
- Author
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Fanelli MF, de Paiva TF Jr, Silva MJ, Benevides CF, Guimarães AP, Gimenes DL, Pinheiro ED, Rinck JA Jr, Nicolau UR, Sanches SM, Mello CA, Dettino AL, Cruz MR, de Melo LM, Formiga MN, de Lima VC, and Chinen LT
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- Adult, Carcinoma, Signet Ring Cell mortality, Carcinoma, Signet Ring Cell therapy, Female, Humans, Male, Multivariate Analysis, Neoplasm Invasiveness, Neoplasm Metastasis, Peritoneal Neoplasms mortality, Retrospective Studies, Stomach Neoplasms mortality, Stomach Neoplasms therapy, Carcinoma, Signet Ring Cell pathology, Carcinoma, Signet Ring Cell secondary, Peritoneal Neoplasms secondary, Stomach Neoplasms pathology
- Abstract
Background: Peritoneal carcinomatosis is a common pattern of recurrence in gastric cancer and is associated with a poor prognosis. Determining predictive factors for peritoneal recurrence can help the selection of patients suitable for more aggressive treatment strategies., Methods: A retrospective chart review of 162 patients diagnosed with gastric cancer with no peritoneal carcinomatosis and treated at a single institution in Brazil from January 1994 to December 2004 was carried out. Univariate and multivariate analyses were performed to identify patient and tumor-related characteristics associated with the development of peritoneal metastasis., Results: Twenty-three (14.2%) patients developed peritoneal carcinomatosis. Three independent factors associated with the development of peritoneal metastasis were identified by multivariate analysis: signet-ring cell histology (odds ratio [OR] = 4.9; P = 0.018), the presence of vascular invasion (OR = 4.8; P = 0.022), and the presence of visceral metastasis at diagnosis (OR = 5.1; P = 0.011). Tumor stages T3 or T4 showed a trend towards significance (P = 0.062)., Conclusions: Patients with gastric cancer presenting with signet-ring histology, vascular invasion, or visceral metastasis appear to be at higher risk for the development of peritoneal carcinomatosis.
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- 2009
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9. Factors correlated with peritoneal carcinomatosis and survival in patients with gastric cancer treated at a single institution in Brazil.
- Author
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Fanelli MF, Silva MJ, de Paiva TF Jr, Chinen LT, Guimarães AP, Gimenes DL, Pinheiro ED, Rinck JA Jr, Nicolau UR, Sanches SM, Melo CA, Dettino AL, Cruz MR, de Melo LM, Formiga MN, and de Lima VC
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- Adenocarcinoma secondary, Adult, Antineoplastic Agents therapeutic use, Brazil epidemiology, Carcinoma, Signet Ring Cell mortality, Carcinoma, Signet Ring Cell secondary, Carcinoma, Signet Ring Cell therapy, Chemotherapy, Adjuvant, Female, Gastrectomy, Humans, Kaplan-Meier Estimate, Male, Neoplasm Staging, Odds Ratio, Palliative Care, Peritoneal Neoplasms secondary, Proportional Hazards Models, Retrospective Studies, Risk Assessment, Risk Factors, Stomach Neoplasms pathology, Time Factors, Treatment Outcome, Adenocarcinoma mortality, Adenocarcinoma therapy, Peritoneal Neoplasms mortality, Peritoneal Neoplasms therapy, Stomach Neoplasms mortality, Stomach Neoplasms therapy
- Abstract
Background: Gastric cancer is the second leading cause of death due to cancer worldwide and is particularly prevalent in Brazil. Promising new therapeutic agents have already shown activity in some gastrointestinal malignancies and their role in gastric cancer will need to be evaluated. Determining the prognostic factors of survival for patients with gastric cancer can help in identifying patients with a worse prognosis after treatment with the current chemotherapeutic regimens., Methods: A retrospective chart review of 186 patients diagnosed with gastric cancer and treated at a single institution in Brazil from January 1994 to December 2004 was carried out. Univariate and multivariate analyses were performed to identify patient- and tumor-related characteristics associated with peritoneal metastasis at diagnosis and with overall survival., Results: Of the 186 patients, 76 were alive at the time of this analysis. The median survival for all patients was 30.1 months. Two independent factors associated with the presence of peritoneal metastasis at diagnosis were identified by multivariate analysis: signet-ring cell type (odds ratio [OR], 10.8; 95% confidence interval [CI], 3.1 to 37.5), and visceral metastasis (OR, 51.8; 95% CI, 12.4 to 215.4). The prognostic factors for poor survival were tumor stage T3 or T4 (hazard ratio [HR], 1.87; 95% CI, 1.09 to 3.22) and visceral metastasis (HR, 4.98; 95% CI, 3.02 to 8.20)., Conclusion: Two factors correlated with peritoneal metastasis and two prognostic factors for survival were identified. These findings may contribute to clinical decision-making, treatment tailoring, and the design of future trials.
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- 2009
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10. Tuberculosis in a patient on temozolomide: a case report.
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de Paiva TF Jr, de Barros e Silva MJ, Rinck JA Jr, Fanelli MF, and Gimenes DL
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- Anti-Infective Agents therapeutic use, Anti-Inflammatory Agents therapeutic use, Anti-Ulcer Agents therapeutic use, Antibiotics, Antitubercular therapeutic use, Anticholesteremic Agents therapeutic use, Anticonvulsants therapeutic use, Atorvastatin, Brain Neoplasms drug therapy, Combined Modality Therapy, Cyclosporine therapeutic use, Dacarbazine adverse effects, Dexamethasone therapeutic use, Female, Fluoxetine therapeutic use, Glioblastoma drug therapy, Heptanoic Acids therapeutic use, Humans, Immunosuppressive Agents therapeutic use, Isoniazid therapeutic use, Middle Aged, Omeprazole therapeutic use, Phenobarbital therapeutic use, Prednisone therapeutic use, Pyrazinamide therapeutic use, Pyrroles therapeutic use, Radiotherapy, Red-Cell Aplasia, Pure drug therapy, Rifampin therapeutic use, Temozolomide, Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use, Tuberculosis, Pulmonary drug therapy, Antineoplastic Agents, Alkylating adverse effects, Dacarbazine analogs & derivatives, Tuberculosis, Pulmonary chemically induced
- Abstract
Temozolomide (TMZ) is a cytotoxic agent of the imidazotetrazine class, chemically related to dacarbazine. Its use poses higher risks of lymphopenia and opportunistic infections. Prophylaxis for Pneumocystis jiroveci must be considered up to 12 months after treatment discontinuation. The due literature (MEDLINE) makes no mention of a possible connection between the use of TMZ and tuberculosis (TB). A female patient, aged 59, featuring glioblastoma multiforme and having undergone solely a brain biopsy, was submitted to TMZ along with radiotherapy. After the first TMZ maintenance cycle, the referred patient was admitted displaying a background of a 40-day afternoon fever and productive coughing. She was thus submitted to a bronchoscopy and LBA, which resulted BAAR 1+/4+. TMZ was then suspended, and rifampicin, isoniazid, and pyrazinamide introduced. Considerations on prophylaxis with isoniazide in cancer patients are long-lived and scarce. Some subgroups are likely to benefit from the prophylactic administration of isoniazide during TMZ treatment, such as those patients under high doses of corticoids, patients with past medical history of TB, the malnourished, patients from endemic regions, and patients with highly reactive tuberculinic tests. That, nevertheless, must not restrict the administration of TMZ, but, rather, stand for a warning about its possible toxicity, and thus mitigate complications.
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- 2009
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