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Factors correlated with peritoneal carcinomatosis and survival in patients with gastric cancer treated at a single institution in Brazil.
- Source :
-
International journal of clinical oncology [Int J Clin Oncol] 2009 Aug; Vol. 14 (4), pp. 326-31. Date of Electronic Publication: 2009 Aug 25. - Publication Year :
- 2009
-
Abstract
- Background: Gastric cancer is the second leading cause of death due to cancer worldwide and is particularly prevalent in Brazil. Promising new therapeutic agents have already shown activity in some gastrointestinal malignancies and their role in gastric cancer will need to be evaluated. Determining the prognostic factors of survival for patients with gastric cancer can help in identifying patients with a worse prognosis after treatment with the current chemotherapeutic regimens.<br />Methods: A retrospective chart review of 186 patients diagnosed with gastric cancer and treated at a single institution in Brazil from January 1994 to December 2004 was carried out. Univariate and multivariate analyses were performed to identify patient- and tumor-related characteristics associated with peritoneal metastasis at diagnosis and with overall survival.<br />Results: Of the 186 patients, 76 were alive at the time of this analysis. The median survival for all patients was 30.1 months. Two independent factors associated with the presence of peritoneal metastasis at diagnosis were identified by multivariate analysis: signet-ring cell type (odds ratio [OR], 10.8; 95% confidence interval [CI], 3.1 to 37.5), and visceral metastasis (OR, 51.8; 95% CI, 12.4 to 215.4). The prognostic factors for poor survival were tumor stage T3 or T4 (hazard ratio [HR], 1.87; 95% CI, 1.09 to 3.22) and visceral metastasis (HR, 4.98; 95% CI, 3.02 to 8.20).<br />Conclusion: Two factors correlated with peritoneal metastasis and two prognostic factors for survival were identified. These findings may contribute to clinical decision-making, treatment tailoring, and the design of future trials.
- Subjects :
- Adenocarcinoma secondary
Adult
Antineoplastic Agents therapeutic use
Brazil epidemiology
Carcinoma, Signet Ring Cell mortality
Carcinoma, Signet Ring Cell secondary
Carcinoma, Signet Ring Cell therapy
Chemotherapy, Adjuvant
Female
Gastrectomy
Humans
Kaplan-Meier Estimate
Male
Neoplasm Staging
Odds Ratio
Palliative Care
Peritoneal Neoplasms secondary
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Risk Factors
Stomach Neoplasms pathology
Time Factors
Treatment Outcome
Adenocarcinoma mortality
Adenocarcinoma therapy
Peritoneal Neoplasms mortality
Peritoneal Neoplasms therapy
Stomach Neoplasms mortality
Stomach Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7772
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 19705243
- Full Text :
- https://doi.org/10.1007/s10147-008-0870-3