1. Coronary Flow Capacity to Identify Stenosis Associated With Coronary Flow Improvement After Revascularization: A Combined Analysis From DEFINE FLOW and IDEAL
- Author
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Tadashi Murai, Valérie E. Stegehuis, Tim P. van de Hoef, Gilbert W. M. Wijntjens, Masahiro Hoshino, Yoshihisa Kanaji, Tomoyo Sugiyama, Rikuta Hamaya, Sukhjinder S. Nijjer, Guus A. de Waard, Mauro Echavarria‐Pinto, Paul Knaapen, Martijn Meuwissen, Justin E. Davies, Niels van Royen, Javier Escaned, Maria Siebes, Richard L. Kirkeeide, K. Lance Gould, Nils P. Johnson, Jan J. Piek, and Tsunekazu Kakuta more...
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coronary blood flow ,coronary flow capacity ,coronary flow reserve ,fractional flow reserve ,percutaneous coronary intervention ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Coronary flow capacity (CFC), which is a categorical assessment based on the combination of hyperemic coronary flow and coronary flow reserve (CFR), has been introduced as a comprehensive assessment of the coronary circulation to overcome the limitations of CFR alone. The aim of this study was to quantify coronary flow changes after percutaneous coronary intervention in relation to the classification of CFC and the current physiological cutoff values of fractional flow reserve, instantaneous wave‐free ratio, and CFR. Methods and Results Using the combined data set from DEFINE FLOW (Distal Evaluation of Functional Performance With Intravascular Sensors to Assess the Narrowing Effect ‐Combined Pressure and Doppler FLOW Velocity Measurements) and IDEAL (Iberian‐Dutch‐English), a total of 133 vessels that underwent intracoronary Doppler flow measurement before and after percutaneous coronary intervention were analyzed. CFC classified prerevascularization lesions as normal (14), mildly reduced (40), moderately reduced (31), and severely reduced (48). Lesions with larger impairment of CFC showed greater increase in coronary flow and vice versa (median percent increase in coronary flow by revascularization: 4.2%, 25.9%, 50.1%, and 145.5%, respectively; P50% increase in coronary flow after percutaneous coronary intervention. Receiver operating characteristic curve analysis demonstrated that only CFC has a superior predictive efficacy to CFR (P more...
- Published
- 2020
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