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1. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

Author: Nichols, E, Steinmetz, JD, Vollset, SE, Fukutaki, K, Chalek, J, Abd-Allah, F, Abdoli, A, Abualhasan, A, Abu-Gharbieh, E, Akram, TT, Al Hamad, H, Alahdab, F, Alanezi, FM, Alipour, V, Almustanyir, S, Amu, H, Ansari, I, Arabloo, J, Ashraf, T, Astell-Burt, T, Ayano, G, Baig, AA, Barnett, A, Barrow, A, Baune, BT, Béjot, Y, Bezabhe, WMM, Bezabih, YM, Bhagavathula, AS, Bhaskar, S, Bhattacharyya, K, Bijani, A, Biswas, A, Bolla, SR, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, RA, Cámera, LA, Cao, C, Carvalho, F, Castro-de-Araujo, LFS, Catalá-López, F, Cerin, E, Chavan, PP, Cherbuin, N, Chu, DT, Costa, VM, Couto, RAS, Dadras, O, Dai, X, Dandona, L, Dandona, R, De la Cruz-Góngora, V, Dhamnetiya, D, Dias da Silva, D, Diaz, D, Douiri, A, Edvardsson, D, Ekholuenetale, M, El Sayed, I, El-Jaafary, SI, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Fares, J, Faro, A, Farooque, U, Feigin, VL, Feng, X, Fereshtehnejad, SM, Fernandes, E, Ferrara, P, Filip, I, Fillit, H, Fischer, F, Gaidhane, S, Galluzzo, L, Ghashghaee, A, Ghith, N, Gialluisi, A, Gilani, SA, Glavan, IR, Gnedovskaya, EV, Golechha, M, Gupta, R, Gupta, Veer, Gupta, VK, Haider, MR, Hall, BJ, Hamidi, S, Hanif, A, Hankey, GJ, Haque, S, Hartono, RK, Hasaballah, AI, Hasan, MT, Hassan, A, Nichols, E, Steinmetz, JD, Vollset, SE, Fukutaki, K, Chalek, J, Abd-Allah, F, Abdoli, A, Abualhasan, A, Abu-Gharbieh, E, Akram, TT, Al Hamad, H, Alahdab, F, Alanezi, FM, Alipour, V, Almustanyir, S, Amu, H, Ansari, I, Arabloo, J, Ashraf, T, Astell-Burt, T, Ayano, G, Baig, AA, Barnett, A, Barrow, A, Baune, BT, Béjot, Y, Bezabhe, WMM, Bezabih, YM, Bhagavathula, AS, Bhaskar, S, Bhattacharyya, K, Bijani, A, Biswas, A, Bolla, SR, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, RA, Cámera, LA, Cao, C, Carvalho, F, Castro-de-Araujo, LFS, Catalá-López, F, Cerin, E, Chavan, PP, Cherbuin, N, Chu, DT, Costa, VM, Couto, RAS, Dadras, O, Dai, X, Dandona, L, Dandona, R, De la Cruz-Góngora, V, Dhamnetiya, D, Dias da Silva, D, Diaz, D, Douiri, A, Edvardsson, D, Ekholuenetale, M, El Sayed, I, El-Jaafary, SI, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Fares, J, Faro, A, Farooque, U, Feigin, VL, Feng, X, Fereshtehnejad, SM, Fernandes, E, Ferrara, P, Filip, I, Fillit, H, Fischer, F, Gaidhane, S, Galluzzo, L, Ghashghaee, A, Ghith, N, Gialluisi, A, Gilani, SA, Glavan, IR, Gnedovskaya, EV, Golechha, M, Gupta, R, Gupta, Veer, Gupta, VK, Haider, MR, Hall, BJ, Hamidi, S, Hanif, A, Hankey, GJ, Haque, S, Hartono, RK, Hasaballah, AI, Hasan, MT, and Hassan, A
Published: 2022

2. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease 2019

Author: Nichols, E, Steinmetz, JD, Vollset, SE, Fukutaki, K, Chalek, J, Abd-Allah, F, Abdoli, A, Abualhasan, A, Abu-Gharbieh, E, Akram, TT, Al Hamad, H, Alahdab, F, Alanezi, FM, Alipour, V, Almustanyir, S, Amu, H, Ansari, I, Arabloo, J, Ashraf, T, Astell-Burt, T, Ayano, G, Ayuso-Mateos, JL, Baig, AA, Barnett, A, Barrow, A, Baune, BT, Bejot, Y, Bezabhe, WMM, Bezabih, YM, Bhagavathula, AS, Bhaskar, S, Bhattacharyya, K, Bijani, A, Biswas, A, Bolla, SR, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, RA, Camera, LA, Cao, C, Carvalho, F, Castro-de-Araujo, LFS, Catala-Lopez, F, Cerin, E, Chavan, PP, Cherbuin, N, Chu, D-T, Costa, VM, Couto, RAS, Dadras, O, Dai, X, Dandona, L, Dandona, R, De La Cruz-Gongora, V, Dhamnetiya, D, da Silva, DD, Diaz, D, Douiri, A, Edvardsson, D, Ekholuenetale, M, El Sayed, I, El-Jaafary, S, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Fares, J, Faro, A, Farooque, U, Feigin, VL, Feng, X, Fereshtehnejad, S-M, Fernandes, E, Ferrara, P, Filip, I, Fillit, H, Fischer, F, Gaidhane, S, Galluzzo, L, Ghashghaee, A, Ghith, N, Gialluisi, A, Gilani, SA, Glavan, I-R, Gnedovskaya, E, Golechha, M, Gupta, R, Gupta, VB, Gupta, VK, Haider, MR, Hall, BJ, Hamidi, S, Hanif, A, Hankey, GJ, Haque, S, Hartono, RK, Hasaballah, A, Hasan, MT, Hassan, A, Hay, S, Hayat, K, Hegazy, M, Heidari, G, Heidari-Soureshjani, R, Herteliu, C, Househ, M, Hussain, R, Hwang, B-F, Iacoviello, L, Iavicoli, I, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irvani, SSN, Iso, H, Iwagami, M, Jabbarinejad, R, Jacob, L, Jain, V, Jayapal, SK, Jayawardena, R, Jha, RP, Jonas, JB, Joseph, N, Kalani, R, Kandel, A, Kandel, H, Karch, A, Kasa, AS, Kassie, GM, Keshavarz, P, Khan, MAB, Khatib, MN, Khoja, TAM, Khubchandani, J, Kim, MS, Kim, YJ, Kisa, A, Kisa, S, Kivimaki, M, Koroshetz, WJ, Koyanagi, A, Kumar, GA, Kumar, M, Lak, HM, Leonardi, M, Li, B, Lim, SS, Liu, X, Liu, Y, Logroscino, G, Lorkowski, S, Lucchetti, G, Saute, RL, Magnani, FG, Malik, AA, Massano, J, Mehndiratta, MM, Menezes, RG, Meretoja, A, Mohajer, B, Ibrahim, NM, Mohammad, Y, Mohammed, A, Mokdad, AH, Mondello, S, Moni, MA, Moniruzzaman, M, Mossie, TB, Nagel, G, Naveed, M, Nayak, VC, Kandel, SN, Nguyen, TH, Oancea, B, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Panda-Jonas, S, Kan, FP, Pasovic, M, Patel, UK, Pathak, M, Peres, MFP, Perianayagam, A, Peterson, CB, Phillips, MR, Pinheiro, M, Piradov, MA, Pond, CD, Potashman, MH, Pottoo, FH, Prada, S, Radfar, A, Raggi, A, Rahim, F, Rahman, M, Ram, P, Ranasinghe, P, Rawaf, DL, Rawaf, S, Rezaei, N, Rezapour, A, Robinson, SR, Romoli, M, Roshandel, G, Sahathevan, R, Sahebkar, A, Sahraian, MA, Sathian, B, Sattin, D, Sawhney, M, Saylan, M, Schiavolin, S, Seylani, A, Sha, F, Shaikh, MA, Shaji, KS, Shannawaz, M, Shetty, JK, Shigematsu, M, Shin, JI, Shiri, R, Santos Silva, DA, Silva, JP, Silva, R, Singh, JA, Skryabin, VY, Skryabina, AA, Smith, AE, Soshnikov, S, Spurlock, EE, Stein, DJ, Sun, J, Tabares-Seisdedos, R, Thakur, B, Timalsina, B, Tovani-Palone, MR, Bach, XT, Tsegaye, GW, Tahbaz, SV, Valdez, PR, Venketasubramanian, N, Vlassov, V, Giang, TV, Linh, GV, Wang, Y-P, Wimo, A, Winkler, AS, Yadav, L, Jabbari, SHY, Yamagishi, K, Yang, L, Yano, Y, Yonemoto, N, Yu, C, Yunusa, I, Zadey, S, Zastrozhin, MS, Zastrozhina, A, Zhang, Z-J, Murray, CJL, Vos, T, Nichols, E, Steinmetz, JD, Vollset, SE, Fukutaki, K, Chalek, J, Abd-Allah, F, Abdoli, A, Abualhasan, A, Abu-Gharbieh, E, Akram, TT, Al Hamad, H, Alahdab, F, Alanezi, FM, Alipour, V, Almustanyir, S, Amu, H, Ansari, I, Arabloo, J, Ashraf, T, Astell-Burt, T, Ayano, G, Ayuso-Mateos, JL, Baig, AA, Barnett, A, Barrow, A, Baune, BT, Bejot, Y, Bezabhe, WMM, Bezabih, YM, Bhagavathula, AS, Bhaskar, S, Bhattacharyya, K, Bijani, A, Biswas, A, Bolla, SR, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, RA, Camera, LA, Cao, C, Carvalho, F, Castro-de-Araujo, LFS, Catala-Lopez, F, Cerin, E, Chavan, PP, Cherbuin, N, Chu, D-T, Costa, VM, Couto, RAS, Dadras, O, Dai, X, Dandona, L, Dandona, R, De La Cruz-Gongora, V, Dhamnetiya, D, da Silva, DD, Diaz, D, Douiri, A, Edvardsson, D, Ekholuenetale, M, El Sayed, I, El-Jaafary, S, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Fares, J, Faro, A, Farooque, U, Feigin, VL, Feng, X, Fereshtehnejad, S-M, Fernandes, E, Ferrara, P, Filip, I, Fillit, H, Fischer, F, Gaidhane, S, Galluzzo, L, Ghashghaee, A, Ghith, N, Gialluisi, A, Gilani, SA, Glavan, I-R, Gnedovskaya, E, Golechha, M, Gupta, R, Gupta, VB, Gupta, VK, Haider, MR, Hall, BJ, Hamidi, S, Hanif, A, Hankey, GJ, Haque, S, Hartono, RK, Hasaballah, A, Hasan, MT, Hassan, A, Hay, S, Hayat, K, Hegazy, M, Heidari, G, Heidari-Soureshjani, R, Herteliu, C, Househ, M, Hussain, R, Hwang, B-F, Iacoviello, L, Iavicoli, I, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irvani, SSN, Iso, H, Iwagami, M, Jabbarinejad, R, Jacob, L, Jain, V, Jayapal, SK, Jayawardena, R, Jha, RP, Jonas, JB, Joseph, N, Kalani, R, Kandel, A, Kandel, H, Karch, A, Kasa, AS, Kassie, GM, Keshavarz, P, Khan, MAB, Khatib, MN, Khoja, TAM, Khubchandani, J, Kim, MS, Kim, YJ, Kisa, A, Kisa, S, Kivimaki, M, Koroshetz, WJ, Koyanagi, A, Kumar, GA, Kumar, M, Lak, HM, Leonardi, M, Li, B, Lim, SS, Liu, X, Liu, Y, Logroscino, G, Lorkowski, S, Lucchetti, G, Saute, RL, Magnani, FG, Malik, AA, Massano, J, Mehndiratta, MM, Menezes, RG, Meretoja, A, Mohajer, B, Ibrahim, NM, Mohammad, Y, Mohammed, A, Mokdad, AH, Mondello, S, Moni, MA, Moniruzzaman, M, Mossie, TB, Nagel, G, Naveed, M, Nayak, VC, Kandel, SN, Nguyen, TH, Oancea, B, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Panda-Jonas, S, Kan, FP, Pasovic, M, Patel, UK, Pathak, M, Peres, MFP, Perianayagam, A, Peterson, CB, Phillips, MR, Pinheiro, M, Piradov, MA, Pond, CD, Potashman, MH, Pottoo, FH, Prada, S, Radfar, A, Raggi, A, Rahim, F, Rahman, M, Ram, P, Ranasinghe, P, Rawaf, DL, Rawaf, S, Rezaei, N, Rezapour, A, Robinson, SR, Romoli, M, Roshandel, G, Sahathevan, R, Sahebkar, A, Sahraian, MA, Sathian, B, Sattin, D, Sawhney, M, Saylan, M, Schiavolin, S, Seylani, A, Sha, F, Shaikh, MA, Shaji, KS, Shannawaz, M, Shetty, JK, Shigematsu, M, Shin, JI, Shiri, R, Santos Silva, DA, Silva, JP, Silva, R, Singh, JA, Skryabin, VY, Skryabina, AA, Smith, AE, Soshnikov, S, Spurlock, EE, Stein, DJ, Sun, J, Tabares-Seisdedos, R, Thakur, B, Timalsina, B, Tovani-Palone, MR, Bach, XT, Tsegaye, GW, Tahbaz, SV, Valdez, PR, Venketasubramanian, N, Vlassov, V, Giang, TV, Linh, GV, Wang, Y-P, Wimo, A, Winkler, AS, Yadav, L, Jabbari, SHY, Yamagishi, K, Yang, L, Yano, Y, Yonemoto, N, Yu, C, Yunusa, I, Zadey, S, Zastrozhin, MS, Zastrozhina, A, Zhang, Z-J, Murray, CJL, and Vos, T
Abstract: BACKGROUND: Given the projected trends in population ageing and population growth, the number of people with dementia is expected to increase. In addition, strong evidence has emerged supporting the importance of potentially modifiable risk factors for dementia. Characterising the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritisation. This study aimed to improve on previous forecasts of dementia prevalence by producing country-level estimates and incorporating information on selected risk factors. METHODS: We forecasted the prevalence of dementia attributable to the three dementia risk factors included in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 (high body-mass index, high fasting plasma glucose, and smoking) from 2019 to 2050, using relative risks and forecasted risk factor prevalence to predict GBD risk-attributable prevalence in 2050 globally and by world region and country. Using linear regression models with education included as an additional predictor, we then forecasted the prevalence of dementia not attributable to GBD risks. To assess the relative contribution of future trends in GBD risk factors, education, population growth, and population ageing, we did a decomposition analysis. FINDINGS: We estimated that the number of people with dementia would increase from 57·4 (95% uncertainty interval 50·4-65·1) million cases globally in 2019 to 152·8 (130·8-175·9) million cases in 2050. Despite large increases in the projected number of people living with dementia, age-standardised both-sex prevalence remained stable between 2019 and 2050 (global percentage change of 0·1% [-7·5 to 10·8]). We estimated that there were more women with dementia than men with dementia globally in 2019 (female-to-male ratio of 1·69 [1·64-1·73]), and we expect this pattern to continue to 2050 (female-to-male ratio of 1·67 [1·52-1·85]). There was geographical heterogeneity in the projected inc
Published: 2022

3. Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019

Author: Peden, AE, Cullen, P, Francis, KL, Moeller, H, Peden, MM, Ye, P, Tian, M, Zou, Z, Sawyer, SM, Aali, A, Abbasi-Kangevari, Z, Abbasi-Kangevari, M, Abdelmasseh, M, Abdoun, M, Abd-Rabu, R, Abdulah, DM, Abdurehman, AM, Abebe, G, Abebe, AM, Abedi, A, Abidi, H, Aboagye, RG, Ali, HA, Abu-Gharbieh, E, Adane, DE, Adane, TD, Addo, IY, Adewole, OG, Adhikari, S, Adnan, M, Adnani, QES, Afolabi, AAB, Afzal, S, Afzal, MS, Aghdam, ZB, Ahinkorah, BO, Ahmad, AR, Ahmad, T, Ahmad, S, Ahmadi, A, Ahmed, H, Ahmed, MB, Ahmed, A, Ahmed, JQ, Rashid, TA, Aithala, JP, Aji, B, Akhlaghdoust, M, Alahdab, F, Alanezi, FM, Alemayehu, A, Al Hamad, H, Ali, SS, Ali, L, Alimohamadi, Y, Alipour, V, Aljunid, SM, Almidani, L, Almustanyir, S, Altirkawi, KA, Alvis-Zakzuk, NJ, Ameyaw, EK, Amin, TT, Amir-Behghadami, M, Amiri, S, Amiri, H, Anagaw, TF, Andrei, T, Andrei, CL, Anvari, D, Anwar, SL, Anyasodor, AE, Arabloo, J, Arab-Zozani, M, Arja, A, Arulappan, J, Arumugam, A, Aryannejad, A, Asgary, S, Ashraf, T, Athari, SS, Atreya, A, Attia, S, Aujayeb, A, Awedew, AF, Azadnajafabad, S, Azangou-Khyavy, M, Azari, S, Jafari, AA, Azizi, H, Azzam, AY, Badiye, AD, Baghcheghi, N, Bagherieh, S, Baig, AA, Bakkannavar, SM, Balta, AB, Banach, M, Banik, PC, Bansal, H, Bardhan, M, Barone-Adesi, F, Barrow, A, Bashiri, A, Baskaran, P, Basu, S, Bayileyegn, NS, Bekel, AA, Bekele, AB, Bendak, S, Bensenor, IM, Berhie, AY, Bhagat, DS, Bhagavathula, AS, Bhardwaj, P, Bhardwaj, N, Bhaskar, S, Bhat, AN, Bhattacharyya, K, Bhutta, ZA, Bibi, S, Bintoro, BS, Bitaraf, S, Bodicha, BBA, Boloor, A, Bouaoud, S, Brown, J, Burkart, K, Butt, NS, Butt, MH, Camera, LA, Rincon, JCC, Cao, C, Carvalho, AF, Carvalho, M, Chakraborty, PA, Chandrasekar, EK, Chang, J-C, Charalampous, P, Charan, J, Chattu, VK, Chekole, BM, Chitheer, A, Cho, DY, Chopra, H, Christopher, DJ, Chukwu, IS, Cruz-Martins, N, Dadras, O, Dahlawi, SMA, Dai, X, Damiani, G, Darmstadt, GL, Soltani, RDC, Darwesh, AM, Das, S, Dastiridou, A, Debela, SA, Dehghan, A, Demeke, GM, Demetriades, AK, Demissie, S, Dessalegn, FN, Desta, AA, Dianatinasab, M, Diao, N, da Silva, DD, Diaz, D, Digesa, LE, Diress, M, Djalalinia, S, Linh, PD, Dodangeh, M, Doku, PN, Dongarwar, D, Dsouza, HL, Eini, E, Ekholuenetale, M, Ekundayo, TC, Elagali, AEM, Elbahnasawy, MA, Elhabashy, HR, Elhadi, M, Zaki, MES, Enyew, DB, Erkhembayar, R, Eskandarieh, S, Etaee, F, Fagbamigbe, AF, Faris, PS, Farmany, A, Faro, A, Farzadfar, F, Fatehizadeh, A, Fereshtehnejad, S-M, Feroze, AH, Fetensa, G, Feyisa, BR, Filip, I, Fischer, F, Foroutan, B, Foroutan, M, Fowobaje, KR, Franklin, RC, Fukumoto, T, Gaal, PA, Gadanya, MA, Galali, Y, Galehdar, N, Ganesan, B, Garg, T, Gebrehiwot, MGD, Gebremariam, YH, Gela, YY, Gerema, U, Ghafourifard, M, Ghamari, S-H, Ghanbari, R, Nour, MG, Gholamalizadeh, M, Gholami, A, Gholamrezanezhad, A, Ghozy, S, Gilani, SA, Gill, TK, Gine-Vazquez, I, Girma, ZA, Glasbey, JC, Glozah, FN, Golechha, M, Goleij, P, Grivna, M, Guadie, HA, Gunawardane, DA, Guo, Y, Gupta, VB, Gupta, S, Gupta, B, Gupta, VK, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hameed, S, Hanfore, LK, Hanif, A, Hargono, A, Harlianto, NI, Harorani, M, Hasaballah, AI, Hasan, SMM, Hassan, A, Hassanipour, S, Hassankhani, H, Havmoeller, RJ, Hay, SI, Heidari, M, Hendrie, D, Heyi, DZ, Hiraike, Y, Holla, R, Horita, N, Hossain, SJ, Hossain, MBH, Shabanan, SH, Hosseinzadeh, M, Hostiuc, S, Hoveidaei, AH, Hsiao, AK, Hussain, S, Hussein, A, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Imani, B, Immurana, M, Inbaraj, LR, Islam, SMS, Islam, RM, Islam, MM, Ismail, NE, Merin, LJ, Jahrami, H, Jakovljevic, M, Janodia, MD, Javaheri, T, Jayapal, SK, Jayarajah, UU, Jayaraman, S, Jeganathan, J, Jemal, B, Jha, RP, Jonas, JB, Joo, T, Joseph, N, Jozwiak, JJ, Jurisson, M, Kabir, A, Kadashetti, V, Kadir, DH, Kalankesh, LR, Kalhor, R, Kamal, VK, Kamath, R, Kandel, H, Kantar, RS, Kapoor, N, Karami, H, Karaye, IM, Karkhah, S, Katoto, PDMC, Kauppila, JH, Kayode, GA, Keikavoosi-Arani, L, Keskin, C, Khader, YS, Khajuria, H, Khammarnia, M, Khan, EA, Khan, MN, Khan, M, Khan, YH, Khan, IA, Khan, A, Khan, MAB, Khanali, J, Khatatbeh, MM, Kashani, HRK, Khazaie, H, Khubchandani, J, Kifle, ZD, Kim, J, Kim, YJ, Kisa, S, Kisa, A, Kneib, CJ, Kompani, F, Koohestani, HR, Koul, PA, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Bicer, BK, Kumar, N, Kumar, M, Kurmi, OP, Laflamme, L, Lam, J, Landires, I, Larijani, B, Lasrado, S, Lauriola, P, La Vecchia, C, Lee, SWH, Lee, YH, Lee, S-W, Lee, W-C, Legesse, SM, Li, S, Lim, SS, Lorenzovici, L, Luke, AO, Madadizadeh, F, Madureira-Carvalho, AM, Abd El Razek, MM, Mahjoub, S, Mahmoodpoor, A, Mahmoudi, R, Mahmoudimanesh, M, Majeed, A, Makki, A, Rad, EM, Malekpour, M-R, Malik, AA, Mallhi, TH, Malta, DC, Mansouri, B, Mansournia, MA, Mathews, E, Maulud, SQ, Mazingi, D, Nasab, EM, Mendoza-Cano, O, Menezes, RG, Mengistu, DA, Mentis, A-FA, Meretoja, A, Mesregah, MK, Mestrovic, T, Gomide Nogueira de Sa, ACM, Miller, TR, Mirghaderi, SP, Mirica, A, Mirmoeeni, S, Mirrakhimov, EM, Mirza, M, Misra, S, Mithra, P, Mittal, C, Moberg, ME, Mohammadi, M, Mohammadi, S, Mohammadi, E, Mohammadpourhodki, R, Mohammed, S, Mohammed, TA, Mohseni, M, Mokdad, AH, Momtazmanesh, S, Monasta, L, Moni, MA, Moreira, RS, Morrison, SD, Mostafavi, E, Isfahani, HM, Mubarik, S, Muccioli, L, Mukherjee, S, Mulita, F, Mustafa, G, Nagarajan, AJ, Naimzada, MD, Nangia, V, Nassereldine, H, Natto, ZS, Nayak, BP, Negoi, I, Nejadghaderi, SA, Nepal, S, Kandel, SN, Noroozi, N, Nunez-Samudio, V, Nzoputam, OJ, Nzoputam, CI, Ochir, C, Odhiambo, JN, Odukoya, OO, Okati-Aliabad, H, Okonji, OC, Olagunju, AT, Bali, AO, Omer, E, Otoiu, A, Otstavnov, SS, Otstavnov, N, Oumer, B, Owolabi, MO, Mahesh, PA, Padron-Monedero, A, Padubidri, JR, Fallahy, MTP, Panda-Jonas, S, Pandi-Perumal, SR, Pardhan, S, Park, E-K, Patel, SK, Pathan, AR, Pati, S, Paudel, U, Pawar, S, Pedersini, P, Peres, MFP, Petcu, I-R, Phillips, MR, Pillay, JD, Piracha, ZZ, Poursadeqiyan, M, Pourtaheri, N, Qattea, I, Radfar, A, 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Maulud, SQ, Mazingi, D, Nasab, EM, Mendoza-Cano, O, Menezes, RG, Mengistu, DA, Mentis, A-FA, Meretoja, A, Mesregah, MK, Mestrovic, T, Gomide Nogueira de Sa, ACM, Miller, TR, Mirghaderi, SP, Mirica, A, Mirmoeeni, S, Mirrakhimov, EM, Mirza, M, Misra, S, Mithra, P, Mittal, C, Moberg, ME, Mohammadi, M, Mohammadi, S, Mohammadi, E, Mohammadpourhodki, R, Mohammed, S, Mohammed, TA, Mohseni, M, Mokdad, AH, Momtazmanesh, S, Monasta, L, Moni, MA, Moreira, RS, Morrison, SD, Mostafavi, E, Isfahani, HM, Mubarik, S, Muccioli, L, Mukherjee, S, Mulita, F, Mustafa, G, Nagarajan, AJ, Naimzada, MD, Nangia, V, Nassereldine, H, Natto, ZS, Nayak, BP, Negoi, I, Nejadghaderi, SA, Nepal, S, Kandel, SN, Noroozi, N, Nunez-Samudio, V, Nzoputam, OJ, Nzoputam, CI, Ochir, C, Odhiambo, JN, Odukoya, OO, Okati-Aliabad, H, Okonji, OC, Olagunju, AT, Bali, AO, Omer, E, Otoiu, A, Otstavnov, SS, Otstavnov, N, Oumer, B, Owolabi, MO, Mahesh, PA, Padron-Monedero, A, Padubidri, JR, Fallahy, MTP, Panda-Jonas, S, Pandi-Perumal, SR, Pardhan, S, Park, E-K, Patel, SK, Pathan, AR, Pati, S, Paudel, U, Pawar, S, Pedersini, P, Peres, MFP, Petcu, I-R, Phillips, MR, Pillay, JD, Piracha, ZZ, Poursadeqiyan, M, Pourtaheri, N, Qattea, I, Radfar, A, Rafiee, A, Raghav, PR, Rahim, F, Rahman, MA, Rahman, FS, Rahman, M, Rahmani, AM, Rahmani, S, Moolambally, SR, Ramazanu, S, Ramezanzadeh, K, Rana, J, Rana, SM, Rao, CR, Rao, SJ, Rashedi, V, Rashidi, M-M, Rastogi, P, Rasul, A, Rawaf, S, Rawaf, DL, Rawal, L, Rawassizadeh, R, Rezaei, N, Rezaeian, M, Rezapour, A, Riad, A, Riaz, M, Rickard, J, Buendia Rodriguez, JA, Roever, L, Ronfani, L, Roy, B, Manjula, S, Saad, AMA, Sabour, S, Sabzmakan, L, Saddik, B, Sadeghi, M, Saeb, MR, Saeed, U, Moghaddam, SS, Safi, SZ, Sahiledengle, B, Sahoo, H, Sahraian, MA, Saki, M, Salamati, P, Salehi, S, Salem, MR, Samy, AM, Sanabria, J, Santric-Milicevic, MM, Saqib, MAN, Sarikhani, Y, Sarveazad, A, Sathian, B, Satpathy, M, Saya, GK, Ceola Schneider, IJ, Schwebel, DC, Seddighi, H, Senthilkumaran, S, Seylani, A, Shabaninejad, H, Shafeghat, M, Shah, PA, Shahabi, S, Shahbandi, A, Shahraki-Sanavi, F, Shaikh, MA, Shaker, E, Shams-Beyranvand, M, Shanawaz, M, Shannawaz, M, Sharew, MMS, Sharma, N, Shashamo, BB, Shayan, M, Sheikhi, RA, Shen, J, Shetty, BSK, Shetty, PH, Shin, JI, Shitaye, NA, Shivakumar, KM, Shobeiri, P, Shorofi, SA, Shrestha, S, Siabani, S, Sidemo, NB, Simegn, W, Sinaei, E, Singh, P, Sinto, R, Siraj, MS, Skryabin, VY, Skryabina, AA, Sleet, DA, Chandan, SN, Socea, B, Solmi, M, Solomon, Y, Song, Y, Sousa, RARC, Soyiri, IN, Stokes, MA, Suleman, M, Abdulkader, RS, Sun, J, Tabares-Seisdedos, R, Tabatabaei, SM, Tabish, M, Taheri, E, Soodejani, MT, Tampa, M, Tan, K-K, Tarigan, IU, Tariqujjaman, M, Tat, NY, Tat, VY, Tavakoli, A, Tefera, BN, Tefera, YM, Temesgen, G, Temsah, M-H, Thangaraju, P, Thapar, R, Thomas, NK, Ticoalu, JHV, Tincho, MB, Tiyuri, A, Togtmol, M, Tovani-Palone, MR, Mai, TNT, Ullah, S, Ullah, I, Umakanthan, S, Unnikrishnan, B, Upadhyay, E, Tahbaz, SV, Valdez, PR, Vasankari, TJ, Vaziri, S, Veroux, M, Vervoort, D, Violante, FS, Vlassov, V, Linh, GV, Waheed, Y, Wang, Y, Wang, Y-P, Wang, C, Wiangkham, T, Wickramasinghe, ND, Woday, AT, Wu, A-M, Yahya, GAT, Jabbari, SHY, Yang, L, Yaya, S, Yigit, A, Yigit, V, Yisihak, E, Yonemoto, N, You, Y, Younis, MZ, Yu, C, Yunusa, I, Yusefi, H, Zahir, M, Bin Zaman, S, Zare, I, Zarea, K, Zastrozhin, MS, Zhang, Z-J, Zhang, Y, Ziapour, A, Zodpey, S, Zoladl, M, Patton, GC, and Ivers, RQ
Abstract: BACKGROUND: Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10-24 years during the past three decades. METHODS: Using the Global Burden of Disease, Injuries, and Risk Factors 2019 Study, we analysed mortality and disability-adjusted life-years (DALYs) attributed to transport and unintentional injuries for adolescents in 204 countries. Burden is reported in absolute numbers and age-standardised rates per 100 000 population by sex, age group (10-14, 15-19, and 20-24 years), and sociodemographic index (SDI) with 95% uncertainty intervals (UIs). We report percentage changes in deaths and DALYs between 1990 and 2019. FINDINGS: In 2019, 369 061 deaths (of which 214 337 [58%] were transport related) and 31·1 million DALYs (of which 16·2 million [52%] were transport related) among adolescents aged 10-24 years were caused by transport and unintentional injuries combined. If compared with other causes, transport and unintentional injuries combined accounted for 25% of deaths and 14% of DALYs in 2019, and showed little improvement from 1990 when such injuries accounted for 26% of adolescent deaths and 17% of adolescent DALYs. Throughout adolescence, transport and unintentional injury fatality rates increased by age group. The unintentional injury burden was higher among males than females for all injury types, except for injuries related to fire, heat, and hot substances, or to adverse effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34·4% (from 17·5 to 11·5 per 100 000) for transport injuries, and by 47·7% (from 15·9 to 8·3 per 100 000) for unintentional injuries. However, in low-SDI nations the absolute number of deaths increased (by 80·5% to 42 774 for transport injuries and by 39·4% to 31 961 for unintentional injuries). In the high-SDI quintile in 2010-19
Published: 2022

4. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.

Author: Global Burden of Disease 2019 Cancer Collaboration, Kocarnik, JM, Compton, K, Dean, FE, Fu, W, Gaw, BL, Harvey, JD, Henrikson, HJ, Lu, D, Pennini, A, Xu, R, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Bisignano, C, Bjørge, T, Bleyer, A, Blyuss, O, Bolarinwa, OA, Bolla, SR, Ababneh, E, Braithwaite, D, Brar, A, Brenner, H, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, Caetano Dos Santos, FL, Cao, Y, Carreras, G, Catalá-López, F, Abbasi-Kangevari, M, Cembranel, F, Cerin, E, Cernigliaro, A, Chakinala, RC, Chattu, SK, Chattu, VK, Chaturvedi, P, Chimed-Ochir, O, Cho, DY, Christopher, DJ, Abbastabar, H, Chu, D-T, Chung, MT, Conde, J, Cortés, S, Cortesi, PA, Costa, VM, Cunha, AR, Dadras, O, Dagnew, AB, Dahlawi, SMA, Abd-Elsalam, SM, Dai, X, Dandona, L, Dandona, R, Darwesh, AM, das Neves, J, De la Hoz, FP, Demis, AB, Denova-Gutiérrez, E, Dhamnetiya, D, Dhimal, ML, Abdoli, A, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Do, HP, Doaei, S, Dorostkar, F, Dos Santos Figueiredo, FW, Driscoll, TR, Ebrahimi, H, Abedi, A, Eftekharzadeh, S, El Tantawi, M, El-Abid, H, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, SI, Eshrati, B, Eskandarieh, S, Esmaeilzadeh, F, Abidi, H, Etemadi, A, Ezzikouri, S, Faisaluddin, M, Faraon, EJA, Fares, J, Farzadfar, F, Feroze, AH, Ferrero, S, Ferro Desideri, L, Filip, I, Abolhassani, H, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gallus, S, Gaspar Fonseca, M, Getachew Obsa, A, Adedeji, IA, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gilani, SA, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Golechha, M, Goleij, P, Adnani, QES, Gomez, RS, Gopalani, SV, Gorini, G, Goudarzi, H, Grosso, G, Gubari, MIM, Guerra, MR, Guha, A, Gunasekera, DS, Gupta, B, Advani, SM, Gupta, VB, Gupta, VK, Gutiérrez, RA, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Afzal, MS, Hanif, A, Haque, S, Harlianto, NI, Haro, JM, Hasaballah, AI, Hassanipour, S, Hay, RJ, Hay, SI, Hayat, K, Heidari, G, Aghaali, M, Heidari, M, Herrera-Serna, BY, Herteliu, C, Hezam, K, Holla, R, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Ahinkorah, BO, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hugo, FN, Hussain, R, Hussein, NR, Hwang, B-F, Iavicoli, I, Ahmad, S, Ibitoye, SE, Ida, F, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Islam, RM, Islam, SMS, Ahmad, T, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jakovljevic, MB, Javaheri, T, Jayaram, S, Jazayeri, SB, Jha, RP, Ahmadi, A, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jürisson, M, Kabir, A, Kahrizi, D, Kalankesh, LR, Kalhor, R, Kaliyadan, F, Ahmadi, S, Kalkonde, Y, Kamath, A, Kameran Al-Salihi, N, Kandel, H, Kapoor, N, Karch, A, Kasa, AS, Katikireddi, SV, Kauppila, JH, Kavetskyy, T, Ahmed Rashid, T, Kebede, SA, Keshavarz, P, Keykhaei, M, Khader, YS, Khalilov, R, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khang, Y-H, Ahmed Salih, Y, Khater, AM, Khayamzadeh, M, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kopec, JA, Koteeswaran, R, Koul, PA, Akalu, GT, Koulmane Laxminarayana, SL, Koyanagi, A, Kucuk Bicer, B, Kugbey, N, Kumar, GA, Kumar, N, Kurmi, OP, Kutluk, T, La Vecchia, C, Aklilu, A, Lami, FH, Landires, I, Lauriola, P, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YH, Leigh, J, Leong, E, Li, J, Akram, T, Li, M-C, Liu, X, Loureiro, JA, Lunevicius, R, Magdy Abd El Razek, M, Majeed, A, Makki, A, Male, S, Malik, AA, Mansournia, MA, Akunna, CJ, Martini, S, Masoumi, SZ, Mathur, P, McKee, M, Mehrotra, R, Mendoza, W, Menezes, RG, Mengesha, EW, Mesregah, MK, Mestrovic, T, Al Hamad, H, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirzaei, H, Mirzaei, HR, Misra, S, Mithra, P, Moghadaszadeh, M, Alahdab, F, Mohammad, KA, Mohammad, Y, Mohammadi, M, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammed, S, Moka, N, Mokdad, AH, Molokhia, M, Monasta, L, Al-Aly, Z, Moni, MA, Moosavi, MA, Moradi, Y, Moraga, P, Morgado-da-Costa, 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Skryabin, VY, Skryabina, AA, Soeberg, MJ, Sofi-Mahmudi, A, Sotoudeh, H, Ansari, F, Steiropoulos, P, Straif, K, Subedi, R, Sufiyan, MB, Sultan, I, Sultana, S, Sur, D, Szerencsés, V, Szócska, M, Tabarés-Seisdedos, R, Ansari-Moghaddam, A, Tabuchi, T, Tadbiri, H, Taherkhani, A, Takahashi, K, Talaat, IM, Tan, K-K, Tat, VY, Tedla, BAA, Tefera, YG, Tehrani-Banihashemi, A, Antwi, MH, Temsah, M-H, Tesfay, FH, Tessema, GA, Thapar, R, Thavamani, A, Thoguluva Chandrasekar, V, Thomas, N, Tohidinik, HR, Touvier, M, Tovani-Palone, MR, Anvari, D, Traini, E, Tran, BX, Tran, KB, Tran, MTN, Tripathy, JP, Tusa, BS, Ullah, I, Ullah, S, Umapathi, KK, Unnikrishnan, B, Anyasodor, AE, Upadhyay, E, Vacante, M, Vaezi, M, Valadan Tahbaz, S, Velazquez, DZ, Veroux, M, Violante, FS, Vlassov, V, Vo, B, Volovici, V, Aqeel, M, Vu, GT, Waheed, Y, Wamai, RG, Ward, P, Wen, YF, Westerman, R, Winkler, AS, Yadav, L, Yahyazadeh Jabbari, SH, Yang, L, Arabloo, J, Yaya, S, Yazie, TSY, Yeshaw, Y, Yonemoto, N, Younis, MZ, Yousefi, Z, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Arab-Zozani, M, Zare, F, Zastrozhin, MS, Zastrozhina, A, Zhang, J, Zhong, C, Zhou, L, Zhu, C, Ziapour, A, Zimmermann, IR, Fitzmaurice, C, Aremu, O, Murray, CJL, Force, LM, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Asemi, Z, Asghari Jafarabadi, M, Ashraf, T, Atorkey, P, Aujayeb, A, Ausloos, M, Awedew, AF, Ayala Quintanilla, BP, Ayenew, T, Azab, MA, Azadnajafabad, S, Azari Jafari, A, Azarian, G, Azzam, AY, Badiye, AD, Bahadory, S, Baig, AA, Baker, JL, Balakrishnan, S, Banach, M, Bärnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Behzadifar, M, Belgaumi, UI, Bezabhe, WMM, Bezabih, YM, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Global Burden of Disease 2019 Cancer Collaboration, Kocarnik, JM, Compton, K, Dean, FE, Fu, W, Gaw, BL, Harvey, JD, Henrikson, HJ, Lu, D, Pennini, A, Xu, R, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Bisignano, C, Bjørge, T, Bleyer, A, Blyuss, O, Bolarinwa, OA, Bolla, SR, Ababneh, E, Braithwaite, D, Brar, A, Brenner, H, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, Caetano Dos Santos, FL, Cao, Y, Carreras, G, Catalá-López, F, Abbasi-Kangevari, M, Cembranel, F, Cerin, E, Cernigliaro, A, Chakinala, RC, Chattu, SK, Chattu, VK, Chaturvedi, P, Chimed-Ochir, O, Cho, DY, Christopher, DJ, Abbastabar, H, Chu, D-T, Chung, MT, Conde, J, Cortés, S, Cortesi, PA, Costa, VM, Cunha, AR, Dadras, O, Dagnew, AB, Dahlawi, SMA, Abd-Elsalam, SM, Dai, X, Dandona, L, Dandona, R, Darwesh, AM, das Neves, J, De la Hoz, FP, Demis, AB, Denova-Gutiérrez, E, Dhamnetiya, D, Dhimal, ML, Abdoli, A, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Do, HP, Doaei, S, Dorostkar, F, Dos Santos Figueiredo, FW, Driscoll, TR, Ebrahimi, H, Abedi, A, Eftekharzadeh, S, El Tantawi, M, El-Abid, H, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, SI, Eshrati, B, Eskandarieh, S, Esmaeilzadeh, F, Abidi, H, Etemadi, A, Ezzikouri, S, Faisaluddin, M, Faraon, EJA, Fares, J, Farzadfar, F, Feroze, AH, Ferrero, S, Ferro Desideri, L, Filip, I, Abolhassani, H, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gallus, S, Gaspar Fonseca, M, Getachew Obsa, A, Adedeji, IA, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gilani, SA, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Golechha, M, Goleij, P, Adnani, QES, Gomez, RS, Gopalani, SV, Gorini, G, Goudarzi, H, Grosso, G, Gubari, MIM, Guerra, MR, Guha, A, Gunasekera, DS, Gupta, B, Advani, SM, Gupta, VB, Gupta, VK, Gutiérrez, RA, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Afzal, MS, Hanif, A, Haque, S, Harlianto, NI, Haro, JM, Hasaballah, AI, Hassanipour, S, Hay, RJ, Hay, SI, Hayat, K, Heidari, G, Aghaali, M, Heidari, M, Herrera-Serna, BY, Herteliu, C, Hezam, K, Holla, R, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Ahinkorah, BO, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hugo, FN, Hussain, R, Hussein, NR, Hwang, B-F, Iavicoli, I, Ahmad, S, Ibitoye, SE, Ida, F, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Islam, RM, Islam, SMS, Ahmad, T, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jakovljevic, MB, Javaheri, T, Jayaram, S, Jazayeri, SB, Jha, RP, Ahmadi, A, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jürisson, M, Kabir, A, Kahrizi, D, Kalankesh, LR, Kalhor, R, Kaliyadan, F, Ahmadi, S, Kalkonde, Y, Kamath, A, Kameran Al-Salihi, N, Kandel, H, Kapoor, N, Karch, A, Kasa, AS, Katikireddi, SV, Kauppila, JH, Kavetskyy, T, Ahmed Rashid, T, Kebede, SA, Keshavarz, P, Keykhaei, M, Khader, YS, Khalilov, R, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khang, Y-H, Ahmed Salih, Y, Khater, AM, Khayamzadeh, M, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kopec, JA, Koteeswaran, R, Koul, PA, Akalu, GT, Koulmane Laxminarayana, SL, Koyanagi, A, Kucuk Bicer, B, Kugbey, N, Kumar, GA, Kumar, N, Kurmi, OP, Kutluk, T, La Vecchia, C, Aklilu, A, Lami, FH, Landires, I, Lauriola, P, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YH, Leigh, J, Leong, E, Li, J, Akram, T, Li, M-C, Liu, X, Loureiro, JA, Lunevicius, R, Magdy Abd El Razek, M, Majeed, A, Makki, A, Male, S, Malik, AA, Mansournia, MA, Akunna, CJ, Martini, S, Masoumi, SZ, Mathur, P, McKee, M, Mehrotra, R, Mendoza, W, Menezes, RG, Mengesha, EW, Mesregah, MK, Mestrovic, T, Al Hamad, H, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirzaei, H, Mirzaei, HR, Misra, S, Mithra, P, Moghadaszadeh, M, Alahdab, F, Mohammad, KA, Mohammad, Y, Mohammadi, M, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammed, S, Moka, N, Mokdad, AH, Molokhia, M, Monasta, L, Al-Aly, Z, Moni, MA, Moosavi, MA, Moradi, Y, Moraga, P, Morgado-da-Costa, J, Morrison, SD, Mosapour, A, Mubarik, S, Mwanri, L, Nagarajan, AJ, Ali, S, Nagaraju, SP, Nagata, C, Naimzada, MD, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Ndejjo, R, Nduaguba, SO, Negoi, I, Negru, SM, Alimohamadi, Y, Neupane Kandel, S, Nguyen, CT, Nguyen, HLT, Niazi, RK, Nnaji, CA, Noor, NM, Nuñez-Samudio, V, Nzoputam, CI, Oancea, B, Ochir, C, Alipour, V, Odukoya, OO, Ogbo, FA, Olagunju, AT, Olakunde, BO, Omar, E, Omar Bali, A, Omonisi, AEE, Ong, S, Onwujekwe, OE, Orru, H, Aljunid, SM, Ortega-Altamirano, DV, Otstavnov, N, Otstavnov, SS, Owolabi, MO, P A, M, Padubidri, JR, Pakshir, K, Pana, A, Panagiotakos, D, Panda-Jonas, S, Alkhayyat, M, Pardhan, S, Park, E-C, Park, E-K, Pashazadeh Kan, F, Patel, HK, Patel, JR, Pati, S, Pattanshetty, SM, Paudel, U, Pereira, DM, Almasi-Hashiani, A, Pereira, RB, Perianayagam, A, Pillay, JD, Pirouzpanah, S, Pishgar, F, Podder, I, Postma, MJ, Pourjafar, H, Prashant, A, Preotescu, L, Almasri, NA, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Radhakrishnan, V, Rafiee, A, Rahim, F, Rahimzadeh, S, Rahman, M, Rahman, MA, Al-Maweri, SAA, Rahmani, AM, Rajai, N, Rajesh, A, Rakovac, I, Ram, P, Ramezanzadeh, K, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Almustanyir, S, Rawassizadeh, R, Razeghinia, MS, Renzaho, AMN, Rezaei, N, Rezapour, A, Roberts, TJ, Rodriguez, JAB, Rohloff, P, Romoli, M, Alonso, N, Ronfani, L, Roshandel, G, Rwegerera, GM, S, M, Sabour, S, Saddik, B, Saeed, U, Sahebkar, A, Sahoo, H, Salehi, S, Alvis-Guzman, N, Salem, MR, Salimzadeh, H, Samaei, M, Samy, AM, Sanabria, J, Sankararaman, S, Santric-Milicevic, MM, Sardiwalla, Y, Sarveazad, A, Sathian, B, Amu, H, Sawhney, M, Saylan, M, Schneider, IJC, Sekerija, M, Seylani, A, Shafaat, O, Shaghaghi, Z, Shaikh, MA, Shamsoddin, E, Shannawaz, M, Anbesu, EW, Sharma, R, Sheikh, A, Sheikhbahaei, S, Shetty, A, Shetty, JK, Shetty, PH, Shibuya, K, Shirkoohi, R, Shivakumar, KM, Shivarov, V, Ancuceanu, R, Siabani, S, Siddappa Malleshappa, SK, Silva, DAS, Singh, JA, Sintayehu, Y, Skryabin, VY, Skryabina, AA, Soeberg, MJ, Sofi-Mahmudi, A, Sotoudeh, H, Ansari, F, Steiropoulos, P, Straif, K, Subedi, R, Sufiyan, MB, Sultan, I, Sultana, S, Sur, D, Szerencsés, V, Szócska, M, Tabarés-Seisdedos, R, Ansari-Moghaddam, A, Tabuchi, T, Tadbiri, H, Taherkhani, A, Takahashi, K, Talaat, IM, Tan, K-K, Tat, VY, Tedla, BAA, Tefera, YG, Tehrani-Banihashemi, A, Antwi, MH, Temsah, M-H, Tesfay, FH, Tessema, GA, Thapar, R, Thavamani, A, Thoguluva Chandrasekar, V, Thomas, N, Tohidinik, HR, Touvier, M, Tovani-Palone, MR, Anvari, D, Traini, E, Tran, BX, Tran, KB, Tran, MTN, Tripathy, JP, Tusa, BS, Ullah, I, Ullah, S, Umapathi, KK, Unnikrishnan, B, Anyasodor, AE, Upadhyay, E, Vacante, M, Vaezi, M, Valadan Tahbaz, S, Velazquez, DZ, Veroux, M, Violante, FS, Vlassov, V, Vo, B, Volovici, V, Aqeel, M, Vu, GT, Waheed, Y, Wamai, RG, Ward, P, Wen, YF, Westerman, R, Winkler, AS, Yadav, L, Yahyazadeh Jabbari, SH, Yang, L, Arabloo, J, Yaya, S, Yazie, TSY, Yeshaw, Y, Yonemoto, N, Younis, MZ, Yousefi, Z, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Arab-Zozani, M, Zare, F, Zastrozhin, MS, Zastrozhina, A, Zhang, J, Zhong, C, Zhou, L, Zhu, C, Ziapour, A, Zimmermann, IR, Fitzmaurice, C, Aremu, O, Murray, CJL, Force, LM, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Asemi, Z, Asghari Jafarabadi, M, Ashraf, T, Atorkey, P, Aujayeb, A, Ausloos, M, Awedew, AF, Ayala Quintanilla, BP, Ayenew, T, Azab, MA, Azadnajafabad, S, Azari Jafari, A, Azarian, G, Azzam, AY, Badiye, AD, Bahadory, S, Baig, AA, Baker, JL, Balakrishnan, S, Banach, M, Bärnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Behzadifar, M, Belgaumi, UI, Bezabhe, WMM, Bezabih, YM, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, and Bhattacharyya, K
Abstract: Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. Evidence Review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). Findings: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low
Published: 2022

5. Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000-2018

Author: Bhattacharjee, NV, Schaeffer, LE, Hay, SI, Lu, D, Schipp, MF, Lazzar-Atwood, A, Donkers, KM, Abady, GG, Abd-Allah, F, Abdelalim, A, Abebo, ZH, Abejie, AN, Abosetugn, AE, Abreu, LG, Abrigo, MRM, Abu-Gharbieh, E, Abushouk, AI, Adamu, AL, Adedeji, IA, Adegbosin, AE, Adekanmbi, V, Adetokunboh, OO, Agudelo-Botero, M, Aji, B, Akinyemi, OO, Alamneh, AA, Alanezi, FM, Alanzi, TM, Albright, J, Alcalde-Rabanal, JE, Alemu, BW, Alhassan, RK, Ali, BA, Ali, S, Alinia, C, Alipour, V, Amit, AML, Amugsi, DA, Anbesu, EW, Ancuceanu, R, Anjomshoa, M, Ansari, F, Antonio, CAT, Anvari, D, Arabloo, J, Arora, A, Artanti, KD, Asemahagn, MA, Asmare, WN, Atout, MMW, Ausloos, M, Awoke, N, Quintanilla, BPA, Ayanore, MA, Aynalem, YA, Ayza, MA, Azene, ZN, Darshan, BB, Badiye, AD, Baig, AA, Bakkannavar, SM, Banach, M, Banik, PC, Bärnighausen, TW, Basaleem, H, Bayati, M, Baye, BA, Bedi, N, Belay, SA, Bhagavathula, AS, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhutta, ZA, Bijani, A, Birhan, TA, Birihane, BM, Bitew, ZW, Bohlouli, S, Bohluli, M, Bojia, HA, Boloor, A, Brady, OJ, Bragazzi, NL, Brunoni, AR, Budhathoki, SS, Nagaraja, SB, Butt, ZA, Cárdenas, R, Castaldelli-Maia, JM, Castro, F, Cernigliaro, A, Charan, J, Chatterjee, P, Chatterjee, S, Chattu, VK, Chaturvedi, S, Chowdhury, MAK, Chu, D-T, Collison, ML, Cook, AJ, Cork, MA, Couto, RAS, Dagnew, B, Dai, H, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Darwesh, AM, Darwish, AH, Daryani, A, Das, JK, Gupta, RD, Dávila-Cervantes, CA, Davis, AC, Weaver, ND, Denova-Gutiérrez, E, Deribe, K, Desalew, A, Deshpande, A, Dessie, A, Deuba, K, Dharmaratne, SD, Dhimal, M, Dhungana, GP, Diaz, D, Didarloo, A, Dipeolu, IO, Doan, LP, Duko, B, Duraes, AR, Dwyer-Lindgren, L, Earl, L, Zaki, MES, Tantawi, ME, Elema, TB, Elhabashy, HR, El-Jaafary, SI, Faris, PS, Faro, A, Farzadfar, F, Feigin, VL, Feleke, BE, Ferede, TY, Fischer, F, Foigt, NA, Folayan, MO, Franklin, RC, Gad, MM, Gaidhane, S, Gardner, WM, Geberemariyam, BS, Gebregiorgis, BG, Gebremedhin, KB, Gebremichael, B, Ghaffarpasand, F, Gilani, SA, Ginindza, TG, Glagn, M, Golechha, M, Gonfa, KB, Goulart, BNG, Gudi, N, Guido, D, Guled, RA, Guo, Y, Hamidi, S, Handiso, DW, Hasaballah, AI, Hassan, A, Hayat, K, Hegazy, MI, Heidari, B, Henry, NJ, Herteliu, C, de, Hidru, HD, Ho, HC, Hoang, CL, Holla, R, Hon, J, Hosseini, M, Hosseinzadeh, M, Househ, M, Hsairi, M, Hu, G, Huda, TM, Hwang, B-F, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Inbaraj, LR, Iqbal, U, Irvani, SSN, Islam, MM, Iwu, CCD, Iwu, CJ, Jain, A, Janodia, MD, Javaheri, T, John-Akinola, YO, Johnson, KB, Joukar, F, Jozwiak, JJ, Kabir, A, Kalankesh, LR, Kalhor, R, Kamath, A, Kamyari, N, Kanchan, OT, Kapoor, N, Matin, BK, Karimi, SE, Kasaye, HK, Kassahun, G, Kassebaum, NJ, Kayode, GA, Karyani, AK, Keiyoro, PN, Kelkay, B, Khalid, N, Khan, MN, Khatab, K, Khater, AM, Khater, MM, Khatib, MN, Kim, YJ, Kimokoti, RW, Kinyoki, DK, Kisa, A, Kisa, S, Kosen, S, Krishan, K, Kulkarni, V, Kumar, GA, Kumar, M, Kumar, N, Kumar, P, Kurmi, OP, Kusuma, D, Vecchia, CL, Lad, SD, Lami, FH, Landires, I, Lansingh, VC, Lasrado, S, Lee, PH, LeGrand, KE, Letourneau, ID, Lewycka, S, Li, B, Li, M-C, Li, S, Liu, X, Lodha, R, Lopez, JCF, Louie, C, Machado, DB, Maled, V, Maleki, S, Malta, DC, Mamun, AA, Manafi, N, Mansournia, MA, Mapoma, CC, Marczak, LB, Martins-Melo, FR, Mehndiratta, MM, Mejia-Rodriguez, F, Mekonnen, TC, Mendoza, W, Menezes, RG, Mengesha, EW, Mersha, AM, Miller, TR, Mini, GK, Mirrakhimov, EM, Misra, S, Moghadaszadeh, M, Mohammad, DK, Mohammadian-Hafshejani, A, Mohammed, JA, Mohammed, S, Mokdad, AH, Montero-Zamora, PA, Moradi, M, Moradzadeh, R, Moraga, P, Mosser, JF, Mousavi, SM, Khaneghah, AM, Munro, SB, Muriithi, MK, Mustafa, G, Muthupandian, S, Nagarajan, AJ, Naik, G, Naimzada, MD, Nangia, V, Nascimento, BR, Nayak, VC, Ndejjo, R, Ndwandwe, DE, Negoi, I, Nguefack-Tsague, G, Ngunjiri, JW, Nguyen, CT, Nguyen, DN, Nguyen, HLT, Nigussie, SN, Nigussie, TTN, Nikbakhsh, R, Nnaji, CA, Nunez-Samudio, V, Oancea, B, Oghenetega, OB, Olagunju, AT, Olusanya, BO, Olusanya, JO, Omer, MO, Onwujekwe, OE, Ortega-Altamirano, DV, Osgood-Zimmerman, AE, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Mahesh, PA, Padubidri, JR, Pana, A, Pandey, A, Pandi-Perumal, SR, Pangaribuan, HU, Parsekar, SS, Pasupula, DK, Patel, UK, Pathak, A, Pathak, M, Pattanshetty, SM, Patton, GC, Paulos, K, Pepito, VCF, Pickering, BV, Pinheiro, M, Piwoz, EG, Pokhrel, KN, Pourjafar, H, Prada, SI, Pribadi, DRA, Syed, ZQ, Rabiee, M, Rabiee, N, Rahim, F, Rahimzadeh, S, Rahman, A, Rahman, MHU, Rahmani, AM, Rai, RK, Ranabhat, CL, Rao, SJ, Rastogi, P, Rathi, P, Rawaf, DL, Rawaf, S, Rawassizadeh, R, Rawat, R, Regassa, LD, Rego, MAS, Reiner, RC, Reshmi, B, Rezapour, A, Ribeiro, AI, Rickard, J, Roever, L, Rumisha, SF, Rwegerera, GM, Sagar, R, Sajadi, SM, Salem, MR, Samy, AM, Santric-Milicevic, MM, Saraswathy, SYI, Sarker, AR, Sartorius, B, Sathian, B, Saxena, D, Sbarra, AN, Sengupta, D, Senthilkumaran, S, Sha, F, Shafaat, O, Shaheen, AA, Shaikh, MA, Shalash, AS, Shannawaz, M, Sheikh, A, Shetty, BSK, Shetty, RS, Shibuya, K, Shiferaw, WS, Shin, JI, Silva, DAS, Singh, NP, Singh, P, Singh, S, Sintayehu, Y, Skryabin, VY, Skryabina, AA, Soheili, A, Soltani, S, Sorrie, MB, Spurlock, EE, Steuben, KM, Sudaryanto, A, Sufiyan, MB, Swartz, SJ, Tadesse, EG, Tamiru, AT, Tapak, L, Tareque, MI, Tarigan, IU, Tesema, GA, Tesfay, FH, Teshome, A, Tessema, ZT, Thankappan, KR, Thapar, R, Thomas, N, Topor-Madry, R, Tovani-Palone, MR, Traini, E, Tran, BX, Truong, PN, Tsegaye, BTBT, Ullah, I, Umeokonkwo, CD, Unnikrishnan, B, Upadhyay, E, Uzochukwu, BSC, VanderHeide, JD, Violante, FS, Vo, B, Wado, YD, Waheed, Y, Wamai, RG, Wang, F, Wang, Y, Wang, Y-P, Wickramasinghe, ND, Wiens, KE, Wiysonge, CS, Woyczynski, L, Wu, A-M, Wu, C, Yamada, T, Yaya, S, Yeshaneh, A, Yeshaw, Y, Yeshitila, YG, Yilma, MT, Yip, P, Yonemoto, N, Yosef, T, Younis, MZ, Yousuf, AY, Yu, C, Yu, Y, Yuce, D, Zafar, S, Zaidi, SS, Zaki, L, Zakzuk, J, Zamanian, M, Zar, HJ, Zastrozhin, MS, Zastrozhina, A, Zelellw, DA, Zhang, Y, Zhang, Z-J, Zhao, X-JG, Zodpey, S, Zuniga, YMH, Local Burden of Disease Exclusive Breastfeeding Collaborators, Bhattacharjee, Natalia V, Schaeffer, Lauren E, Hay, Simon I, Duko, Bereket, Yeshaw, Yigizie, Local Burden of Disease Exclusive Breastfeeding Collaborators, Bhattacharjee N.V., Schaeffer L.E., Hay S.I., Lu D., Schipp M.F., Lazzar-Atwood A., Donkers K.M., Abady G.G., Abd-Allah F., Abdelalim A., Abebo Z.H., Abejie A.N., Abosetugn A.E., Abreu L.G., Abrigo M.R.M., Abu-Gharbieh E., Abushouk A.I., Adamu A.L., Adedeji I.A., Adegbosin A.E., Adekanmbi V., Adetokunboh O.O., Agudelo-Botero M., Aji B., Akinyemi O.O., Alamneh A.A., Alanezi F.M., Alanzi T.M., Albright J., Alcalde-Rabanal J.E., Alemu B.W., Alhassan R.K., Ali B.A., Ali S., Alinia C., Alipour V., Amit A.M.L., Amugsi D.A., Anbesu E.W., Ancuceanu R., Anjomshoa M., Ansari F., Antonio C.A.T., Anvari D., Arabloo J., Arora A., Artanti K.D., Asemahagn M.A., Asmare W.N., Atout M.M.W., Ausloos M., Awoke N., Quintanilla B.P.A., Ayanore M.A., Aynalem Y.A., Ayza M.A., Azene Z.N., Darshan B.B., Badiye A.D., Baig A.A., Bakkannavar S.M., Banach M., Banik P.C., Barnighausen T.W., Basaleem H., Bayati M., Baye B.A., Bedi N., Belay S.A., Bhagavathula A.S., Bhandari D., Bhardwaj N., Bhardwaj P., Bhutta Z.A., Bijani A., Birhan T.A., Birihane B.M., Bitew Z.W., Bohlouli S., Bohluli M., Bojia H.A., Boloor A., Brady O.J., Bragazzi N.L., Brunoni A.R., Budhathoki S.S., Nagaraja S.B., Butt Z.A., Cardenas R., Castaldelli-Maia J.M., Castro F., Cernigliaro A., Charan J., Chatterjee P., Chatterjee S., Chattu V.K., Chaturvedi S., Chowdhury M.A.K., Chu D.-T., Collison M.L., Cook A.J., Cork M.A., Couto R.A.S., Dagnew B., Dai H., Dandona L., Dandona R., Daneshpajouhnejad P., Darwesh A.M., Darwish A.H., Daryani A., Das J.K., Gupta R.D., Davila-Cervantes C.A., Davis A.C., Weaver N.D., Denova-Gutierrez E., Deribe K., Desalew A., Deshpande A., Dessie A., Deuba K., Dharmaratne S.D., Dhimal M., Dhungana G.P., Diaz D., Didarloo A., Dipeolu I.O., Doan L.P., Duko B., Duraes A.R., Dwyer-Lindgren L., Earl L., Zaki M.E.S., Tantawi M.E., Elema T.B., Elhabashy H.R., El-Jaafary S.I., Faris P.S., Faro A., Farzadfar F., Feigin V.L., Feleke B.E., Ferede T.Y., Fischer F., Foigt N.A., Folayan M.O., Franklin R.C., Gad M.M., Gaidhane S., Gardner W.M., Geberemariyam B.S., Gebregiorgis B.G., Gebremedhin K.B., Gebremichael B., Ghaffarpasand F., Gilani S.A., Ginindza T.G., Glagn M., Golechha M., Gonfa K.B., Goulart B.N.G., Gudi N., Guido D., Guled R.A., Guo Y., Hamidi S., Handiso D.W., Hasaballah A.I., Hassan A., Hayat K., Hegazy M.I., Heidari B., Henry N.J., Herteliu C., de Hidru H.D., Ho H.C., Hoang C.L., Holla R., Hon J., Hosseini M., Hosseinzadeh M., Househ M., Hsairi M., Hu G., Huda T.M., Hwang B.-F., Ibitoye S.E., Ilesanmi O.S., Ilic I.M., Ilic M.D., Inbaraj L.R., Iqbal U., Irvani S.S.N., Islam M.M., Iwu C.C.D., Iwu C.J., Jain A., Janodia M.D., Javaheri T., John-Akinola Y.O., Johnson K.B., Joukar F., Jozwiak J.J., Kabir A., Kalankesh L.R., Kalhor R., Kamath A., Kamyari N., Kanchan O.T., Kapoor N., Matin B.K., Karimi S.E., Kasaye H.K., Kassahun G., Kassebaum N.J., Kayode G.A., Karyani A.K., Keiyoro P.N., Kelkay B., Khalid N., Khan M.N., Khatab K., Khater A.M., Khater M.M., Khatib M.N., Kim Y.J., Kimokoti R.W., Kinyoki D.K., Kisa A., Kisa S., Kosen S., Krishan K., Kulkarni V., Kumar G.A., Kumar M., Kumar N., Kumar P., Kurmi O.P., Kusuma D., Vecchia C.L., Lad S.D., Lami F.H., Landires I., Lansingh V.C., Lasrado S., Lee P.H., LeGrand K.E., Letourneau I.D., Lewycka S., Li B., Li M.-C., Li S., Liu X., Lodha R., Lopez J.C.F., Louie C., Machado D.B., Maled V., Maleki S., Malta D.C., Mamun A.A., Manafi N., Mansournia M.A., Mapoma C.C., Marczak L.B., Martins-Melo F.R., Mehndiratta M.M., Mejia-Rodriguez F., Mekonnen T.C., Mendoza W., Menezes R.G., Mengesha E.W., Mersha A.M., Miller T.R., Mini G.K., Mirrakhimov E.M., Misra S., Moghadaszadeh M., Mohammad D.K., Mohammadian-Hafshejani A., Mohammed J.A., Mohammed S., Mokdad A.H., Montero-Zamora P.A., Moradi M., Moradzadeh R., Moraga P., Mosser J.F., Mousavi S.M., Khaneghah A.M., Munro S.B., Muriithi M.K., Mustafa G., Muthupandian S., Nagarajan A.J., Naik G., Naimzada M.D., Nangia V., Nascimento B.R., Nayak V.C., Ndejjo R., Ndwandwe D.E., Negoi I., Nguefack-Tsague G., Ngunjiri J.W., Nguyen C.T., Nguyen D.N., Nguyen H.L.T., Nigussie S.N., Nigussie T.T.N., Nikbakhsh R., Nnaji C.A., Nunez-Samudio V., Oancea B., Oghenetega O.B., Olagunju A.T., Olusanya B.O., Olusanya J.O., Omer M.O., Onwujekwe O.E., Ortega-Altamirano D.V., Osgood-Zimmerman A.E., Otstavnov N., Otstavnov S.S., Owolabi M.O., Mahesh P.A., Padubidri J.R., Pana A., Pandey A., Pandi-Perumal S.R., Pangaribuan H.U., Parsekar S.S., Pasupula D.K., Patel U.K., Pathak A., Pathak M., Pattanshetty S.M., Patton G.C., Paulos K., Pepito V.C.F., Pickering B.V., Pinheiro M., Piwoz E.G., Pokhrel K.N., Pourjafar H., Prada S.I., Pribadi D.R.A., Syed Z.Q., Rabiee M., Rabiee N., Rahim F., Rahimzadeh S., Rahman A., Rahman M.H.U., Rahmani A.M., Rai R.K., Ranabhat C.L., Rao S.J., Rastogi P., Rathi P., Rawaf D.L., Rawaf S., Rawassizadeh R., Rawat R., Regassa L.D., Rego M.A.S., Reiner R.C., Reshmi B., Rezapour A., Ribeiro A.I., Rickard J., Roever L., Rumisha S.F., Rwegerera G.M., Sagar R., Sajadi S.M., Salem M.R., Samy A.M., Santric-Milicevic M.M., Saraswathy S.Y.I., Sarker A.R., Sartorius B., Sathian B., Saxena D., Sbarra A.N., Sengupta D., Senthilkumaran S., Sha F., Shafaat O., Shaheen A.A., Shaikh M.A., Shalash A.S., Shannawaz M., Sheikh A., Shetty B.S.K., Shetty R.S., Shibuya K., Shiferaw W.S., Shin J.I., Silva D.A.S., Singh N.P., Singh P., Singh S., Sintayehu Y., Skryabin V.Y., Skryabina A.A., Soheili A., Soltani S., Sorrie M.B., Spurlock E.E., Steuben K.M., Sudaryanto A., Sufiyan M.B., Swartz S.J., Tadesse E.G., Tamiru A.T., Tapak L., Tareque M.I., Tarigan I.U., Tesema G.A., Tesfay F.H., Teshome A., Tessema Z.T., Thankappan K.R., Thapar R., Thomas N., Topor-Madry R., Tovani-Palone M.R., Traini E., Tran B.X., Truong P.N., Tsegaye B.T.B.T., Ullah I., Umeokonkwo C.D., Unnikrishnan B., Upadhyay E., Uzochukwu B.S.C., VanderHeide J.D., Violante F.S., Vo B., Wado Y.D., Waheed Y., Wamai R.G., Wang F., Wang Y., Wang Y.-P., Wickramasinghe N.D., Wiens K.E., Wiysonge C.S., Woyczynski L., Wu A.-M., Wu C., Yamada T., Yaya S., Yeshaneh A., Yeshaw Y., Yeshitila Y.G., Yilma M.T., Yip P., Yonemoto N., Yosef T., Younis M.Z., Yousuf A.Y., Yu C., Yu Y., Yuce D., Zafar S., Zaidi S.S., Zaki L., Zakzuk J., Zamanian M., Zar H.J., Zastrozhin M.S., Zastrozhina A., Zelellw D.A., Zhang Y., Zhang Z.-J., Zhao X.-J.G., Zodpey S., Zuniga Y.M.H., Collaborators, Local Burden of Disease Exclusive Breastfeeding, and Instituto de Saúde Pública da Universidade do Porto
Subjects: RJ101, Psychological intervention, Breastfeeding, Social Sciences, geography, Behavioral Neuroscience, 0302 clinical medicine, RA0421, Prevalence, Psychology, policy making, 030212 general & internal medicine, Policy Making, humans, media_common, CHILD GROWTH FAILURE, Developing world, 0303 health sciences, education.field_of_study, Psychology, Biological, Geography, Psychology, Experimental, Health Status Disparitie, Multidisciplinary Sciences, Breast Feeding, breast feeding, Scale (social sciences), Science & Technology - Other Topics, Life Sciences & Biomedicine, Human, AFRICA, Social Psychology, Inequality, spatial analysis, media_common.quotation_subject, public policy, Population, prevalence, Public policy, Developing country, Experimental and Cognitive Psychology, Public Policy, Local Burden of Disease Exclusive Breastfeeding Collaborators, Article, Developing Countrie, 03 medical and health sciences, Environmental health, Humans, Nutrition disorders, education, Developing Countries, 030304 developmental biology, Spatial Analysis, Science & Technology, Neurosciences, Health Status Disparities, developing countries, health status disparities, Risk factors, Neurosciences & Neurology, Breast feeding
Abstract: Exclusive breastfeeding (EBF)—giving infants only breast-milk for the first 6 months of life—is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and progress across low- and middle-income countries (LMICs) are required for planning policy and interventions. Here we present a geospatial analysis of EBF prevalence estimates from 2000 to 2018 across 94 LMICs mapped to policy-relevant administrative units (for example, districts), quantify subnational inequalities and their changes over time, and estimate probabilities of meeting the World Health Organization’s Global Nutrition Target (WHO GNT) of ≥70% EBF prevalence by 2030. While six LMICs are projected to meet the WHO GNT of ≥70% EBF prevalence at a national scale, only three are predicted to meet the target in all their district-level units by 2030., Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.
Published: 2021

6. Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author: Collaborators, GAM, Ward, JL, Azzopardi, PS, Francis, KL, Santelli, JS, Skirbekk, V, Sawyer, SM, Kassebaum, NJ, Mokdad, AH, Hay, SI, Abd-Allah, F, Abdoli, A, Abdollahi, M, Abedi, A, Abolhassani, H, Abreu, LG, Abrigo, MRM, Abu-Gharbieh, E, Abushouk, AI, Adebayo, OM, Adekanmbi, V, Adham, D, Advani, SM, Afshari, K, Agrawal, A, Ahmad, T, Ahmadi, K, Ahmed, AE, Aji, B, Akombi-Inyang, B, Alahdab, F, Al-Aly, Z, Alam, K, Alanezi, FM, Alanzi, TM, Alcalde-Rabanal, JE, Alemu, BW, Al-Hajj, S, Alhassan, RK, Ali, S, Alicandro, G, Alijanzadeh, M, Aljunid, SM, Almasi-Hashiani, A, Almasri, NA, Al-Mekhlafi, HM, Alonso, J, Al-Raddadi, RM, Altirkawi, KA, Alvis-Guzman, N, Amare, AT, Amini, S, Aminorroaya, A, Amit, AML, Amugsi, DA, Ancuceanu, R, Anderlini, D, Andrei, CL, Androudi, S, Ansari, F, Ansari, I, Antonio, CAT, Anvari, D, Anwer, R, Appiah, SCY, Arabloo, J, Arab-Zozani, M, Ärnlöv, J, Asaad, M, Asadi-Aliabadi, M, Asadi-Pooya, AA, Atout, MMW, Ausloos, M, Avenyo, EK, Avila-Burgos, L, Quintanilla, BPA, Ayano, G, Aynalem, YA, Azari, S, Azene, ZN, Bakhshaei, MH, Bakkannavar, SM, Banach, M, Banik, PC, Barboza, MA, Barker-Collo, SL, Bärnighausen, TW, Basu, S, Baune, BT, Bayati, M, Bedi, N, Beghi, E, Bekuma, TT, Bell, AW, Bell, ML, Benjet, C, Bensenor, IM, Berhe, AK, Berhe, K, Berman, AE, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhattarai, S, Bhutta, ZA, Bijani, A, Bikbov, B, Biondi, A, Birhanu, TTM, Biswas, RK, Bohlouli, S, Bolla, SR, Boloor, A, Borschmann, R, Boufous, S, Bragazzi, NL, Braithwaite, D, Breitborde, NJK, Brenner, H, Britton, GB, Burns, RA, Nagaraja, SB, Butt, ZA, dos Santos, FLC, Cámera, LA, Campos-Nonato, IR, Rincon, JCC, Cárdenas, R, Carreras, G, Carrero, JJ, Carvalho, F, Castaldelli-Maia, JM, Castañeda-Orjuela, CA, Castelpietra, G, Catalá-López, F, Cerin, E, Chandan, JS, Chang, H-Y, Chang, J-C, Charan, J, Chattu, VK, Chaturvedi, S, Choi, J-YJ, Chowdhury, MAK, Christopher, DJ, Chu, D-T, Chung, MT, Chung, S-C, Cicuttini, FM, Constantin, TV, Costa, VM, Dahlawi, SMA, Dai, H, Dai, X, Damiani, G, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Darwesh, AM, Dávila-Cervantes, CA, Davletov, K, De la Hoz, FP, De Leo, D, Dervenis, N, Desai, R, Desalew, A, Deuba, K, Dharmaratne, SD, Dhungana, GP, Dianatinasab, M, da Silva, DD, Diaz, D, Didarloo, A, Djalalinia, S, Dorostkar, F, Doshi, CP, Doshmangir, L, Doyle, KE, Duraes, AR, Kalan, ME, Ebtehaj, S, Edvardsson, D, Tantawi, ME, Elgendy, IY, El-Jaafary, SI, Elsharkawy, A, Eshrati, B, Eskandarieh, S, Esmaeilnejad, S, Esmaeilzadeh, F, Esteghamati, S, Faro, A, Farzadfar, F, Fattahi, N, Feigin, VL, Ferede, TY, Fereshtehnejad, S-M, Fernandes, E, Ferrara, P, Filip, I, Fischer, F, Fisher, JL, Foigt, NA, Folayan, MO, Fomenkov, AA, Foroutan, M, Fukumoto, T, Gad, MM, Gaidhane, AM, Gallus, S, Gebre, T, Gebremedhin, KB, Gebremeskel, GG, Gebremeskel, L, Gebreslassie, AA, Gesesew, HA, Ghadiri, K, Ghafourifard, M, Ghamari, F, Ghashghaee, A, Gilani, SA, Gnedovskaya, EV, Godinho, MA, Golechha, M, Goli, S, Gona, 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M., Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Bill & Melinda Gates Foundation, Ward J.L., Azzopardi P.S., Francis K.L., Santelli J.S., Skirbekk V., Sawyer S.M., Kassebaum N.J., Mokdad A.H., Hay S.I., Abd-Allah F., Abdoli A., Abdollahi M., Abedi A., Abolhassani H., Abreu L.G., Abrigo M.R.M., Abu-Gharbieh E., Abushouk A.I., Adebayo O.M., Adekanmbi V., Adham D., Advani S.M., Afshari K., Agrawal A., Ahmad T., Ahmadi K., Ahmed A.E., Aji B., Akombi-Inyang B., Alahdab F., Al-Aly Z., Alam K., Alanezi F.M., Alanzi T.M., Alcalde-Rabanal J.E., Alemu B.W., Al-Hajj S., Alhassan R.K., Ali S., Alicandro G., Alijanzadeh M., Aljunid S.M., Almasi-Hashiani A., Almasri N.A., Al-Mekhlafi H.M., Alonso J., Al-Raddadi R.M., Altirkawi K.A., Alvis-Guzman N., Amare A.T., Amini S., Aminorroaya A., Amit A.M.L., Amugsi D.A., Ancuceanu R., Anderlini D., Andrei C.L., Androudi S., Ansari 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Moraga, P, Morrison, S, Mosapour, A, Mousavi Khaneghah, A, Mueller, U, Muriithi, M, Murray, C, Muthupandian, S, Naderi, M, Nagarajan, A, Naghavi, M, Naimzada, M, Nangia, V, Nayak, V, Nazari, J, Ndejjo, R, Negoi, I, Negoi, R, Netsere, H, Nguefack-Tsague, G, Nguyen, D, Nguyen, H, Nie, J, Ningrum, D, Nnaji, C, Nomura, S, Noubiap, J, Nowak, C, Nunez-Samudio, V, Ogbo, F, Oghenetega, O, Oh, I, Oladnabi, M, Olagunju, A, Olusanya, B, Olusanya, J, Omar Bali, A, Omer, M, Onwujekwe, O, Ortiz, A, Otoiu, A, Otstavnov, N, Otstavnov, S, Overland, S, Owolabi, M, P A, M, Padubidri, J, Pakshir, K, Palladino, R, Pana, A, Panda-Jonas, S, Pandey, A, Panelo, C, Park, E, Patten, S, Peden, A, Pepito, V, Peprah, E, Pereira, J, Pesudovs, K, Pham, H, Phillips, M, Piradov, M, Pirsaheb, M, Postma, M, Pottoo, F, Pourjafar, H, Pourshams, A, Prada, S, Pupillo, E, Quazi Syed, Z, Rabiee, M, Rabiee, N, Radfar, A, Rafiee, A, Raggi, A, Rahim, F, Rahimi-Movaghar, V, Rahman, M, Ramezanzadeh, K, Ranabhat, C, Rao, S, Rashedi, V, Rastogi, P, Rathi, P, Rawaf, D, Rawaf, S, Rawal, L, Rawassizadeh, R, Renzaho, A, Rezaei, N, Rezai, M, Riahi, S, Rickard, J, Roever, L, Ronfani, L, Roth, G, Rubagotti, E, Rumisha, S, Rwegerera, G, Sabour, S, Sachdev, P, Saddik, B, Sadeghi, E, Saeedi Moghaddam, S, Sagar, R, Sahebkar, A, Sahraian, M, Sajadi, S, Salem, M, Salimzadeh, H, Samy, A, Sanabria, J, Santric-Milicevic, M, Saraswathy, S, Sarrafzadegan, N, Sarveazad, A, Sathish, T, Sattin, D, Saxena, D, Saxena, S, Schiavolin, S, Schwebel, D, Schwendicke, F, Senthilkumaran, S, Sepanlou, S, Sha, F, Shafaat, O, Shahabi, S, Shaheen, A, Shaikh, M, Shakiba, S, Shamsi, M, Shannawaz, M, Sharafi, K, Sheikh, A, Sheikhbahaei, S, Shetty, B, Shi, P, Shigematsu, M, Shin, J, Shiri, R, Shuval, K, Siabani, S, Sigfusdottir, I, Sigurvinsdottir, R, Silva, D, Silva, J, Simonetti, B, Singh, J, Singh, V, Sinke, A, Skryabin, V, Slater, H, Smith, E, Sobhiyeh, M, Sobngwi, E, Soheili, A, Somefun, O, Sorrie, M, Soyiri, I, Sreeramareddy, C, Stein, D, Stokes, M, Sudaryanto, A, Sultan, I, Tabares-Seisdedos, R, Tabuchi, T, Tadakamadla, S, Taherkhani, A, Tamiru, A, Tareque, M, Thankappan, K, Thapar, R, Thomas, N, Titova, M, Tonelli, M, Tovani-Palone, M, Tran, B, Travillian, R, Tsai, A, Tsatsakis, A, Tudor Car, L, Uddin, R, Unim, B, Unnikrishnan, B, Upadhyay, E, Vacante, M, Valadan Tahbaz, S, Valdez, P, Varughese, S, Vasankari, T, Venketasubramanian, N, Villeneuve, P, Violante, F, Vlassov, V, Vos, T, Vu, G, Waheed, Y, Wamai, R, Wang, Y, Westerman, R, Wickramasinghe, N, Wu, A, Wu, C, Yahyazadeh Jabbari, S, Yamagishi, K, Yano, Y, Yaya, S, Yazdi-Feyzabadi, V, Yeshitila, Y, Yip, P, Yonemoto, N, Yoon, S, Younis, M, Yousefinezhadi, T, Yu, C, Yu, Y, Yuce, D, Zaidi, S, Zaman, S, Zamani, M, Zamanian, M, Zarafshan, H, Zarei, A, Zastrozhin, M, Zhang, Y, Zhang, Z, Zhao, X, Zhu, C, Patton, G, and Viner, R
Subjects: Male, Joves -- Mortalitat, ADOLESCENT HEALTH, CHILDREN, Socioeconomic Factor, Global Burden of Disease, RA0421, Cause of Death, Medicine, Young adult, Child, 11 Medical and Health Sciences, Cause of death, education.field_of_study, Adolescent, Age Distribution, Female, Humans, Mortality, Sex Distribution, Socioeconomic Factors, Young Adult, Mortality rate, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Articles, Hälsovetenskaper, MIDDLE-INCOME, MENTAL-HEALTH, Adolescent health, INTERVENTIONS, Human, SUICIDE, Total fertility rate, Population, Adolescent Health, Adolescents -- Mortalitat, General & Internal Medicine, Health Sciences, QUALITY, Medicine [Science], Social determinants of health, INCOME COUNTRIES, education, business.industry, TRENDS, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Years of potential life lost, INJURIES, business, Demography
Abstract: Background Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of deaths, years of life lost, and mortality rates by sex and age group in people aged 10–24 years in 204 countries and territories from 1950 to 2019 by use of estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods We report trends in estimated total numbers of deaths and mortality rate per 100 000 population in young people aged 10–24 years by age group (10–14 years, 15–19 years, and 20–24 years) and sex in 204 countries and territories between 1950 and 2019 for all causes, and between 1980 and 2019 by cause of death. We analyse variation in outcomes by region, age group, and sex, and compare annual rate of change in mortality in young people aged 10–24 years with that in children aged 0–9 years from 1990 to 2019. We then analyse the association between mortality in people aged 10–24 years and socioeconomic development using the GBD Socio-demographic Index (SDI), a composite measure based on average national educational attainment in people older than 15 years, total fertility rate in people younger than 25 years, and income per capita. We assess the association between SDI and all-cause mortality in 2019, and analyse the ratio of observed to expected mortality by SDI using the most recent available data release (2017). Findings In 2019 there were 1·49 million deaths (95% uncertainty interval 1·39–1·59) worldwide in people aged 10–24 years, of which 61% occurred in males. 32·7% of all adolescent deaths were due to transport injuries, unintentional injuries, or interpersonal violence and conflict; 32·1% were due to communicable, nutritional, or maternal causes; 27·0% were due to non-communicable diseases; and 8·2% were due to self-harm. Since 1950, deaths in this age group decreased by 30·0% in females and 15·3% in males, and sex-based differences in mortality rate have widened in most regions of the world. Geographical variation has also increased, particularly in people aged 10–14 years. Since 1980, communicable and maternal causes of death have decreased sharply as a proportion of total deaths in most GBD super-regions, but remain some of the most common causes in sub-Saharan Africa and south Asia, where more than half of all adolescent deaths occur. Annual percentage decrease in all-cause mortality rate since 1990 in adolescents aged 15–19 years was 1·3% in males and 1·6% in females, almost half that of males aged 1–4 years (2·4%), and around a third less than in females aged 1–4 years (2·5%). The proportion of global deaths in people aged 0–24 years that occurred in people aged 10–24 years more than doubled between 1950 and 2019, from 9·5% to 21·6%. Interpretation Variation in adolescent mortality between countries and by sex is widening, driven by poor progress in reducing deaths in males and older adolescents. Improving global adolescent mortality will require action to address the specific vulnerabilities of this age group, which are being overlooked. Furthermore, indirect effects of the COVID-19 pandemic are likely to jeopardise efforts to improve health outcomes including mortality in young people aged 10–24 years. There is an urgent need to respond to the changing global burden of adolescent mortality, address inequities where they occur, and improve the availability and quality of primary mortality data in this age group. Funding Bill & Melinda Gates Foundation.
Published: 2021

7. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019:A Systematic Analysis for the Global Burden of Disease Study 2019

Author: Global Burden of Disease 2019 Cancer Collaboration, Kocarnik, JM, Compton, K, Dean, FE, Fu, W, Gaw, BL, Harvey, JD, Henrikson, HJ, Lu, D, Pennini, A, Xu, R, Ababneh, E, Abbasi-Kangevari, M, Abbastabar, H, Abd-Elsalam, SM, Abdoli, A, Abedi, A, Abidi, H, Abolhassani, H, Adedeji, IA, Adnani, QES, Advani, SM, Afzal, MS, Aghaali, M, Ahinkorah, BO, Ahmad, S, Ahmad, T, Ahmadi, A, Ahmadi, S, Ahmed Rashid, T, Ahmed Salih, Y, Akalu, GT, Aklilu, A, Akram, T, Akunna, CJ, Al Hamad, H, Alahdab, F, Al-Aly, Z, Ali, S, Alimohamadi, Y, Alipour, V, Aljunid, SM, Alkhayyat, M, Almasi-Hashiani, A, Almasri, NA, Al-Maweri, SAA, Almustanyir, S, Alonso, N, Alvis-Guzman, N, Amu, H, Anbesu, EW, Ancuceanu, R, Ansari, F, Ansari-Moghaddam, A, Antwi, MH, Anvari, D, Anyasodor, AE, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aremu, O, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Asemi, Z, Asghari Jafarabadi, M, Ashraf, T, Atorkey, P, Aujayeb, A, Ausloos, M, Awedew, AF, Ayala Quintanilla, BP, Ayenew, T, Azab, MA, Azadnajafabad, S, Azari Jafari, A, Azarian, G, Azzam, AY, Badiye, AD, Bahadory, S, Baig, AA, Baker, JL, Balakrishnan, S, Banach, M, Bärnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Behzadifar, M, Belgaumi, UI, Bezabhe, WMM, Bezabih, YM, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Bisignano, C, Bjørge, T, Bleyer, A, Blyuss, O, Bolarinwa, OA, Bolla, SR, Braithwaite, D, Brar, A, Brenner, H, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, Caetano Dos Santos, FL, Cao, Y, Carreras, G, Catalá-López, F, Cembranel, F, Cerin, E, Cernigliaro, A, Chakinala, RC, Chattu, SK, Chattu, VK, Chaturvedi, P, Chimed-Ochir, O, Cho, DY, Christopher, DJ, Chu, D-T, Chung, MT, Conde, J, Cortés, S, Cortesi, PA, Costa, VM, Cunha, AR, Dadras, O, Dagnew, AB, Dahlawi, SMA, Dai, X, Dandona, L, Dandona, R, Darwesh, AM, Das Neves, J, De la Hoz, FP, Demis, AB, Denova-Gutiérrez, E, Dhamnetiya, D, Dhimal, ML, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Do, HP, Doaei, S, Dorostkar, F, Dos Santos Figueiredo, FW, Driscoll, TR, Ebrahimi, H, Eftekharzadeh, S, El Tantawi, M, El-Abid, H, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, SI, Eshrati, B, Eskandarieh, S, Esmaeilzadeh, F, Etemadi, A, Ezzikouri, S, Faisaluddin, M, Faraon, EJA, Fares, J, Farzadfar, F, Feroze, AH, Ferrero, S, Ferro Desideri, L, Filip, I, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gallus, S, Gaspar Fonseca, M, Getachew Obsa, A, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gilani, SA, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Golechha, M, Goleij, P, Gomez, RS, Gopalani, SV, Gorini, G, Goudarzi, H, Grosso, G, Gubari, MIM, Guerra, MR, Guha, A, Gunasekera, DS, Gupta, B, Gupta, VB, Gupta, VK, Gutiérrez, RA, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Hanif, A, Haque, S, Harlianto, NI, Haro, JM, Hasaballah, AI, Hassanipour, S, Hay, RJ, Hay, SI, Hayat, K, Heidari, G, Heidari, M, Herrera-Serna, BY, Herteliu, C, Hezam, K, Holla, R, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hugo, FN, Hussain, R, Hussein, NR, Hwang, B-F, Iavicoli, I, Ibitoye, SE, Ida, F, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Islam, RM, Islam, SMS, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jakovljevic, MB, Javaheri, T, Jayaram, S, Jazayeri, SB, Jha, RP, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jürisson, M, Kabir, A, Kahrizi, D, Kalankesh, LR, Kalhor, R, Kaliyadan, F, Kalkonde, Y, Kamath, A, Kameran Al-Salihi, N, Kandel, H, Kapoor, N, Karch, A, Kasa, AS, Katikireddi, SV, Kauppila, JH, Kavetskyy, T, Kebede, SA, Keshavarz, P, Keykhaei, M, Khader, YS, Khalilov, R, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khang, Y-H, Khater, AM, Khayamzadeh, M, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kopec, JA, Koteeswaran, R, 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Y., Mohammadi M., Mohammadi S.M., Mohammadian-Hafshejani A., Mohammed S., Moka N., Mokdad A.H., Molokhia M., Monasta L., Moni M.A., Moosavi M.A., Moradi Y., Moraga P., Morgado-Da-Costa J., Morrison S.D., Mosapour A., Mubarik S., Mwanri L., Nagarajan A.J., Nagaraju S.P., Nagata C., Naimzada M.D., Nangia V., Naqvi A.A., Narasimha Swamy S., Ndejjo R., Nduaguba S.O., Negoi I., Negru S.M., Neupane Kandel S., Nguyen C.T., Nguyen H.L.T., Niazi R.K., Nnaji C.A., Noor N.M., Nunez-Samudio V., Nzoputam C.I., Oancea B., Ochir C., Odukoya O.O., Ogbo F.A., Olagunju A.T., Olakunde B.O., Omar E., Omar Bali A.O., Omonisi A.E.E., Ong S., Onwujekwe O.E., Orru H., Ortega-Altamirano D.V., Otstavnov N., Otstavnov S.S., Owolabi M.O., P A M., Padubidri J.R., Pakshir K., Pana A., Panagiotakos D., Panda-Jonas S., Pardhan S., Park E.-C., Park E.-K., Pashazadeh Kan F., Patel H.K., Patel J.R., Pati S., Pattanshetty S.M., Paudel U., Pereira D.M., Pereira R.B., Perianayagam A., Pillay J.D., Pirouzpanah S., Pishgar F., Podder I., Postma M.J., Pourjafar H., Prashant A., Preotescu L., Rabiee M., Rabiee N., Radfar A., Radhakrishnan R.A., Radhakrishnan V., Rafiee A., Rahim F., Rahimzadeh S., Rahman M., Rahman M.A., Rahmani A.M., Rajai N., Rajesh A., Rakovac I., Ram P., Ramezanzadeh K., Ranabhat K., Ranasinghe P., Rao C.R., Rao S.J., Rawassizadeh R., Razeghinia M.S., Renzaho A.M.N., Rezaei N., Rezapour A., Roberts T.J., Rodriguez J.A.B., Rohloff P., Romoli M., Ronfani L., Roshandel G., Rwegerera G.M., Manjula S., Sabour S., Saddik B., Saeed U., Sahebkar A., Sahoo H., Salehi S., Salem M.R., Salimzadeh H., Samaei M., Samy A.M., Sanabria J., Sankararaman S., Santric-Milicevic M.M., Sardiwalla Y., Sarveazad A., Sathian B., Sawhney M., Saylan M., Schneider I.J.J., Sekerija M., Seylani A., Shafaat O., Shaghaghi Z., Shaikh M.A., Shamsoddin E., Shannawaz M., Sharma R., Sheikh A., Sheikhbahaei S., Shetty A., Shetty J.K., Shetty P.H., Shibuya K., Shirkoohi R., Shivakumar K.M., Shivarov V., Siabani S., Siddappa Malleshappa S.K., Silva D.A.S., Singh J.A., Sintayehu Y., Skryabin V.Y., Skryabina A.A., Soeberg M.J., Sofi-Mahmudi A., Sotoudeh H., Steiropoulos P., Straif K., Subedi R., Sufiyan M.B., Sultan I., Sultana S., Sur D., Szerencses V., Szocska M., Tabares-Seisdedos R., Tabuchi T., Tadbiri H., Taherkhani A., Takahashi K., Talaat I.M., Tan K.-K., Tat V.Y., Tedla B.A.A., Tefera Y.G., Tehrani-Banihashemi A., Temsah M., Tesfay F.H., Tessema G.A., Thapar R., Thavamani A., Thoguluva Chandrasekar V., Thomas N., Tohidinik H.R., Touvier M., Tovani-Palone M.R., Traini E., Tran B.X., Tran K.B., Tran M.T.N., Tripathy J.P., Tusa B.S., Ullah I., Ullah S., Umapathi K.K., Unnikrishnan B., Upadhyay E., Vacante M., Vaezi M., Valadan Tahbaz S., Velazquez D.Z., Veroux M., Violante F.S., Vlassov V., Vo B., Volovici V., Vu G.T., Waheed Y., Wamai R.G., Ward P., Wen Y.F., Westerman R., Winkler A.S., Yadav L., Yahyazadeh Jabbari S.H., Yang L., Yaya S., Yazie T.S.Y., Yeshaw Y., Yonemoto N., Younis M.Z., Yousefi Z., Yu C., Yuce D., Yunusa I., Zadnik V., Zare F., Zastrozhin M.S., Zastrozhina A., Zhang J., Zhong C., Zhou L., Zhu C., Ziapour A., Zimmermann I.R., Fitzmaurice C., Murray C.J.L., Force L.M., Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, Kuwait University (Kuwait), National University of Malaysia (Malasia), Alexander von Humboldt Foundation, Federal Ministry of Education & Research (Alemania), NIH - National Cancer Institute (NCI) (Estados Unidos), Unión Europea. Comisión Europea. European Research Council (ERC), Unión Europea. Comisión Europea. H2020, Novo Nordisk Foundation, National Health and Medical Research Council (Australia), Jazan University (Arabia Saudí), Romanian National Authority for Scientific Research and Innovation, Ministry of Education (Brasil), National Heart Foundation of Australia, Ministry of Education, Science and Technological Development (Serbia), NHS - Research Scotland (Reino Unido), Medical Research Council (Reino Unido), Scottish Government (Reino Unido), Jatiya Kabi Kazi Nazrul Islam University (Bangladesh), Xiamen University (Malasia), Manipal Academy of Higher Education (India), Sistema Nacional de Investigación (Panamá), Secretaría Nacional de Ciencia, Tecnología e Innovación (Panamá), King College London, National Health Service (Reino Unido), Government of the Russian Federation, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), National Council for Scientific and Technological Development (Brasil), Cancer Prevention and Research Institute of Texas (Estados Unidos), Fundação para a Ciência e Tecnologia (Portugal), Neurosurgery, Kocarnik, J. M., Compton, K., Dean, F. E., Fu, W., Gaw, B. L., Harvey, J. D., Henrikson, H. J., Lu, D., Pennini, A., Xu, R., Ababneh, E., Abbasi-Kangevari, M., Abbastabar, H., Abd-Elsalam, S. M., Abdoli, A., Abedi, A., Abidi, H., Abolhassani, H., Adedeji, I. A., Adnani, Q. E. S., Advani, S. M., Afzal, M. S., Aghaali, M., Ahinkorah, B. O., Ahmad, S., Ahmad, T., Ahmadi, A., Ahmadi, S., Ahmed Rashid, T., Ahmed Salih, Y., Akalu, G. T., Aklilu, A., Akram, T., Akunna, C. J., Al Hamad, H., Alahdab, F., Al-Aly, Z., Ali, S., Alimohamadi, Y., Alipour, V., Aljunid, S. M., Alkhayyat, M., Almasi-Hashiani, A., Almasri, N. A., Al-Maweri, S. A. A., Almustanyir, S., Alonso, N., Alvis-Guzman, N., Amu, H., Anbesu, E. W., Ancuceanu, R., Ansari, F., Ansari-Moghaddam, A., Antwi, M. H., Anvari, D., Anyasodor, A. E., Aqeel, M., Arabloo, J., Arab-Zozani, M., Aremu, O., Ariffin, H., Aripov, T., Arshad, M., Artaman, A., Arulappan, J., Asemi, Z., Asghari Jafarabadi, M., Ashraf, T., Atorkey, P., Aujayeb, A., Ausloos, M., Awedew, A. F., Ayala Quintanilla, B. P., Ayenew, T., Azab, M. A., Azadnajafabad, S., Azari Jafari, A., Azarian, G., Azzam, A. Y., Badiye, A. D., Bahadory, S., Baig, A. A., Baker, J. L., Balakrishnan, S., Banach, M., Barnighausen, T. W., Barone-Adesi, F., Barra, F., Barrow, A., Behzadifar, M., Belgaumi, U. I., Bezabhe, W. M. M., Bezabih, Y. M., Bhagat, D. S., Bhagavathula, A. S., Bhardwaj, N., Bhardwaj, P., Bhaskar, S., Bhattacharyya, K., Bhojaraja, V. S., Bibi, S., Bijani, A., Biondi, A., Bisignano, C., Bjorge, T., Bleyer, A., Blyuss, O., Bolarinwa, O. A., Bolla, S. R., Braithwaite, D., Brar, A., Brenner, H., Bustamante-Teixeira, M. T., Butt, N. S., Butt, Z. A., Caetano Dos Santos, F. L., Cao, Y., Carreras, G., Catala-Lopez, F., Cembranel, F., Cerin, E., Cernigliaro, A., Chakinala, R. C., Chattu, S. K., Chattu, V. K., Chaturvedi, P., Chimed-Ochir, O., Cho, D. Y., Christopher, D. J., Chu, D. -T., Chung, M. T., Conde, J., Cortes, S., Cortesi, P. A., Costa, V. M., Cunha, A. R., Dadras, O., Dagnew, A. B., Dahlawi, S. M. A., Dai, X., Dandona, L., Dandona, R., Darwesh, A. M., Das Neves, J., De La Hoz, F. P., Demis, A. B., Denova-Gutierrez, E., Dhamnetiya, D., Dhimal, M. L., Dhimal, M., Dianatinasab, M., Diaz, D., Djalalinia, S., Do, H. P., Doaei, S., Dorostkar, F., Dos Santos Figueiredo, F. W., Driscoll, T. R., Ebrahimi, H., Eftekharzadeh, S., El Tantawi, M., El-Abid, H., Elbarazi, I., Elhabashy, H. R., Elhadi, M., El-Jaafary, S. I., Eshrati, B., Eskandarieh, S., Esmaeilzadeh, F., Etemadi, A., Ezzikouri, S., Faisaluddin, M., Faraon, E. J. A., Fares, J., Farzadfar, F., Feroze, A. H., Ferrero, S., Ferro Desideri, L., Filip, I., Fischer, F., Fisher, J. L., Foroutan, M., Fukumoto, T., Gaal, P. A., Gad, M. M., Gadanya, M. A., Gallus, S., Gaspar Fonseca, M., Getachew Obsa, A., Ghafourifard, M., Ghashghaee, A., Ghith, N., Gholamalizadeh, M., Gilani, S. A., Ginindza, T. G., Gizaw, A. T. T., Glasbey, J. C., Golechha, M., Goleij, P., Gomez, R. S., Gopalani, S. V., Gorini, G., Goudarzi, H., Grosso, G., Gubari, M. I. M., Guerra, M. R., Guha, A., Gunasekera, D. S., Gupta, B., Gupta, V. B., Gupta, V. K., Gutierrez, R. A., Hafezi-Nejad, N., Haider, M. R., Haj-Mirzaian, A., Halwani, R., Hamadeh, R. R., Hameed, S., Hamidi, S., Hanif, A., Haque, S., Harlianto, N. I., Haro, J. M., Hasaballah, A. I., Hassanipour, S., Hay, R. J., Hay, S. I., Hayat, K., Heidari, G., Heidari, M., Herrera-Serna, B. Y., Herteliu, C., Hezam, K., Holla, R., Hossain, M. M., Hossain, M. B. H., Hosseini, M. -S., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsairi, M., Huang, J., Hugo, F. N., Hussain, R., Hussein, N. R., Hwang, B. -F., Iavicoli, I., Ibitoye, S. E., Ida, F., Ikuta, K. S., Ilesanmi, O. S., Ilic, I. M., Ilic, M. D., Irham, L. M., Islam, J. Y., Islam, R. M., Islam, S. M. S., Ismail, N. E., Isola, G., Iwagami, M., Jacob, L., Jain, V., Jakovljevic, M. B., Javaheri, T., Jayaram, S., Jazayeri, S. B., Jha, R. P., Jonas, J. B., Joo, T., Joseph, N., Joukar, F., Jurisson, M., Kabir, A., Kahrizi, D., Kalankesh, L. R., Kalhor, R., Kaliyadan, F., Kalkonde, Y., Kamath, A., Kameran Al-Salihi, N., Kandel, H., Kapoor, N., Karch, A., Kasa, A. S., Katikireddi, S. V., Kauppila, J. H., Kavetskyy, T., Kebede, S. A., Keshavarz, P., Keykhaei, M., Khader, Y. S., Khalilov, R., Khan, G., Khan, M., Khan, M. N., Khan, M. A. B., Khang, Y. -H., Khater, A. M., Khayamzadeh, M., Kim, G. R., Kim, Y. J., Kisa, A., Kisa, S., Kissimova-Skarbek, K., Kopec, J. A., Koteeswaran, R., Koul, P. A., Koulmane Laxminarayana, S. L., Koyanagi, A., Kucuk Bicer, B., Kugbey, N., Kumar, G. A., Kumar, N., Kurmi, O. P., Kutluk, T., La Vecchia, C., Lami, F. H., Landires, I., Lauriola, P., Lee, S. -W., Lee, S. W. H., Lee, W. -C., Lee, Y. H., Leigh, J., Leong, E., Li, J., Li, M. -C., Liu, X., Loureiro, J. A., Lunevicius, R., Magdy Abd El Razek, M., Majeed, A., Makki, A., Male, S., Malik, A. A., Mansournia, M. A., Martini, S., Masoumi, S. Z., Mathur, P., Mckee, M., Mehrotra, R., Mendoza, W., Menezes, R. G., Mengesha, E. W., Mesregah, M. K., Mestrovic, T., Miao Jonasson, J., Miazgowski, B., Miazgowski, T., Michalek, I. M., Miller, T. R., Mirzaei, H., Mirzaei, H. R., Misra, S., Mithra, P., Moghadaszadeh, M., Mohammad, K. A., Mohammad, Y., Mohammadi, M., Mohammadi, S. M., Mohammadian-Hafshejani, A., Mohammed, S., Moka, N., Mokdad, A. H., Molokhia, M., Monasta, L., Moni, M. A., Moosavi, M. A., Moradi, Y., Moraga, P., Morgado-Da-Costa, J., Morrison, S. D., Mosapour, A., Mubarik, S., Mwanri, L., Nagarajan, A. J., Nagaraju, S. P., Nagata, C., Naimzada, M. D., Nangia, V., Naqvi, A. A., Narasimha Swamy, S., Ndejjo, R., Nduaguba, S. O., Negoi, I., Negru, S. M., Neupane Kandel, S., Nguyen, C. T., Nguyen, H. L. T., Niazi, R. K., Nnaji, C. A., Noor, N. M., Nunez-Samudio, V., Nzoputam, C. I., Oancea, B., Ochir, C., Odukoya, O. O., Ogbo, F. A., Olagunju, A. T., Olakunde, B. O., Omar, E., Omar Bali, A., Omonisi, A. E. E., Ong, S., Onwujekwe, O. E., Orru, H., Ortega-Altamirano, D. V., Otstavnov, N., Otstavnov, S. S., Owolabi, M. O., P A, M., Padubidri, J. R., Pakshir, K., Pana, A., Panagiotakos, D., Panda-Jonas, S., Pardhan, S., Park, E. -C., Park, E. -K., Pashazadeh Kan, F., Patel, H. K., Patel, J. R., Pati, S., Pattanshetty, S. M., Paudel, U., Pereira, D. M., Pereira, R. B., Perianayagam, A., Pillay, J. D., Pirouzpanah, S., Pishgar, F., Podder, I., Postma, M. J., Pourjafar, H., Prashant, A., Preotescu, L., Rabiee, M., Rabiee, N., Radfar, A., Radhakrishnan, R. A., Radhakrishnan, V., Rafiee, A., Rahim, F., Rahimzadeh, S., Rahman, M., Rahman, M. A., Rahmani, A. M., Rajai, N., Rajesh, A., Rakovac, I., Ram, P., Ramezanzadeh, K., Ranabhat, K., Ranasinghe, P., Rao, C. R., Rao, S. J., Rawassizadeh, R., Razeghinia, M. S., Renzaho, A. M. N., Rezaei, N., Rezapour, A., Roberts, T. J., Rodriguez, J. A. B., Rohloff, P., Romoli, M., Ronfani, L., Roshandel, G., Rwegerera, G. M., Manjula, S., Sabour, S., Saddik, B., Saeed, U., Sahebkar, A., Sahoo, H., Salehi, S., Salem, M. R., Salimzadeh, H., Samaei, M., Samy, A. M., Sanabria, J., Sankararaman, S., Santric-Milicevic, M. M., Sardiwalla, Y., Sarveazad, A., Sathian, B., Sawhney, M., Saylan, M., Schneider, I. J. C., Sekerija, M., Seylani, A., Shafaat, O., Shaghaghi, Z., Shaikh, M. A., Shamsoddin, E., Shannawaz, M., Sharma, R., Sheikh, A., Sheikhbahaei, S., Shetty, A., Shetty, J. K., Shetty, P. H., Shibuya, K., Shirkoohi, R., Shivakumar, K. M., Shivarov, V., Siabani, S., Siddappa Malleshappa, S. K., Silva, D. A. S., Singh, J. A., Sintayehu, Y., Skryabin, V. Y., Skryabina, A. A., Soeberg, M. J., Sofi-Mahmudi, A., Sotoudeh, H., Steiropoulos, P., Straif, K., Subedi, R., Sufiyan, M. B., Sultan, I., Sultana, S., Sur, D., Szerencses, V., Szocska, M., Tabares-Seisdedos, R., Tabuchi, T., Tadbiri, H., Taherkhani, A., Takahashi, K., Talaat, I. M., Tan, K. -K., Tat, V. Y., Tedla, B. A. A., Tefera, Y. G., Tehrani-Banihashemi, A., Temsah, M. -H., Tesfay, F. H., Tessema, G. A., Thapar, R., Thavamani, A., Thoguluva Chandrasekar, V., Thomas, N., Tohidinik, H. R., Touvier, M., Tovani-Palone, M. R., Traini, E., Tran, B. X., Tran, K. B., Tran, M. T. N., Tripathy, J. P., Tusa, B. S., Ullah, I., Ullah, S., Umapathi, K. K., Unnikrishnan, B., Upadhyay, E., Vacante, M., Vaezi, M., Valadan Tahbaz, S., Velazquez, D. Z., Veroux, M., Violante, F. S., Vlassov, V., Vo, B., Volovici, V., Vu, G. T., Waheed, Y., Wamai, R. G., Ward, P., Wen, Y. F., Westerman, R., Winkler, A. S., Yadav, L., Yahyazadeh Jabbari, S. H., Yang, L., Yaya, S., Yazie, T. S. Y., Yeshaw, Y., Yonemoto, N., Younis, M. Z., Yousefi, Z., Yu, C., Yuce, D., Yunusa, I., Zadnik, V., Zare, F., Zastrozhin, M. S., Zastrozhina, A., Zhang, J., Zhong, C., Zhou, L., Zhu, C., Ziapour, A., Zimmermann, I. R., Fitzmaurice, C., Murray, C. J. L., and Force, L. M.
Subjects: Cancer Research, GBD, 195 COUNTRIES, Global Health, 1117 Public Health and Health Services, Global Burden of Disease, SDG 3 - Good Health and Well-being, WORLDWIDE, Risk Factors, Neoplasms, SURVEILLANCE, SUPPORT, Global Burden of Disease 2019 Cancer Collaboration, Prevalence, Online First, cancer, Humans, 1112 Oncology and Carcinogenesis, public health, cancer, burden of diseases, PROGRESS, Original Investigation, Global burden, Science & Technology, CHALLENGES, Research, Incidence, Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 [VDP], COVID-19, 1112 Oncology and Carcinogenesis, 1117 Public Health and Health Services, Disability-Adjusted Life Years, mortality, STATISTICS, Oncology, Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019, HEALTH-CARE, TERRITORIES, Quality-Adjusted Life Years, Life Sciences & Biomedicine, Comments
Abstract: Key Points Question What was the burden of cancer globally and across Sociodemographic Index (SDI) groupings in 2019, and how has incidence, morbidity, and mortality changed since 2010? Findings In this systematic analysis, there were 23.6 million new global cancer cases in 2019 (17.2 million when excluding those with nonmelanoma skin cancer), 10.0 million cancer deaths, and an estimated 250 million disability-adjusted life years estimated to be due to cancer; since 2010, these represent increases of 26.3%, 20.9%, and 16.0%, respectively. Absolute cancer burden increased in all SDI quintiles since 2010, but the largest percentage increases occurred in the low and low-middle SDI quintiles. Meanings The study results suggest that increased cancer prevention and control efforts are needed to equitably address the evolving and increasing burden of cancer across the SDI spectrum., Importance The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. Objective To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. Evidence Review The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). Findings In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. Conclusions and Relevance The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world., The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 examines cancer burden and trends globally for 204 countries and territories and by Socio-demographic Index quintiles from 2010 to 2019.
Published: 2022

8. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.

Author: Global Burden of Disease 2019 Cancer Collaboration, Kocarnik, JM, Compton, K, Dean, FE, Fu, W, Gaw, BL, Harvey, JD, Henrikson, HJ, Lu, D, Pennini, A, Xu, R, Ababneh, E, Abbasi-Kangevari, M, Abbastabar, H, Abd-Elsalam, SM, Abdoli, A, Abedi, A, Abidi, H, Abolhassani, H, Adedeji, IA, Adnani, QES, Advani, SM, Afzal, MS, Aghaali, M, Ahinkorah, BO, Ahmad, S, Ahmad, T, Ahmadi, A, Ahmadi, S, Ahmed Rashid, T, Ahmed Salih, Y, Akalu, GT, Aklilu, A, Akram, T, Akunna, CJ, Al Hamad, H, Alahdab, F, Al-Aly, Z, Ali, S, Alimohamadi, Y, Alipour, V, Aljunid, SM, Alkhayyat, M, Almasi-Hashiani, A, Almasri, NA, Al-Maweri, SAA, Almustanyir, S, Alonso, N, Alvis-Guzman, N, Amu, H, Anbesu, EW, Ancuceanu, R, Ansari, F, Ansari-Moghaddam, A, Antwi, MH, Anvari, D, Anyasodor, AE, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aremu, O, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Asemi, Z, Asghari Jafarabadi, M, Ashraf, T, Atorkey, P, Aujayeb, A, Ausloos, M, Awedew, AF, Ayala Quintanilla, BP, Ayenew, T, Azab, MA, Azadnajafabad, S, Azari Jafari, A, Azarian, G, Azzam, AY, Badiye, AD, Bahadory, S, Baig, AA, Baker, JL, Balakrishnan, S, Banach, M, Bärnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Behzadifar, M, Belgaumi, UI, Bezabhe, WMM, Bezabih, YM, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Bisignano, C, Bjørge, T, Bleyer, A, Blyuss, O, Bolarinwa, OA, Bolla, SR, Braithwaite, D, Brar, A, Brenner, H, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, Caetano Dos Santos, FL, Cao, Y, Carreras, G, Catalá-López, F, Cembranel, F, Cerin, E, Cernigliaro, A, Chakinala, RC, Chattu, SK, Chattu, VK, Chaturvedi, P, Chimed-Ochir, O, Cho, DY, Christopher, DJ, Chu, D-T, Chung, MT, Conde, J, Cortés, S, Cortesi, PA, Costa, VM, Cunha, AR, Dadras, O, Dagnew, AB, Dahlawi, SMA, Dai, X, Dandona, L, Dandona, R, Darwesh, AM, das Neves, J, De la Hoz, FP, Demis, AB, Denova-Gutiérrez, E, Dhamnetiya, D, Dhimal, ML, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Do, HP, Doaei, S, Dorostkar, F, Dos Santos Figueiredo, FW, Driscoll, TR, Ebrahimi, H, Eftekharzadeh, S, El Tantawi, M, El-Abid, H, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, SI, Eshrati, B, Eskandarieh, S, Esmaeilzadeh, F, Etemadi, A, Ezzikouri, S, Faisaluddin, M, Faraon, EJA, Fares, J, Farzadfar, F, Feroze, AH, Ferrero, S, Ferro Desideri, L, Filip, I, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gallus, S, Gaspar Fonseca, M, Getachew Obsa, A, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gilani, SA, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Golechha, M, Goleij, P, Gomez, RS, Gopalani, SV, Gorini, G, Goudarzi, H, Grosso, G, Gubari, MIM, Guerra, MR, Guha, A, Gunasekera, DS, Gupta, B, Gupta, VB, Gupta, VK, Gutiérrez, RA, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Hanif, A, Haque, S, Harlianto, NI, Haro, JM, Hasaballah, AI, Hassanipour, S, Hay, RJ, Hay, SI, Hayat, K, Heidari, G, Heidari, M, Herrera-Serna, BY, Herteliu, C, Hezam, K, Holla, R, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hugo, FN, Hussain, R, Hussein, NR, Hwang, B-F, Iavicoli, I, Ibitoye, SE, Ida, F, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Islam, RM, Islam, Shariful, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jakovljevic, MB, Javaheri, T, Jayaram, S, Jazayeri, SB, Jha, RP, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jürisson, M, Kabir, A, Kahrizi, D, Kalankesh, LR, Kalhor, R, Kaliyadan, F, Kalkonde, Y, Kamath, A, Kameran Al-Salihi, N, Kandel, H, Kapoor, N, Karch, A, Kasa, AS, Katikireddi, SV, Kauppila, JH, Kavetskyy, T, Kebede, SA, Keshavarz, P, Keykhaei, M, Khader, YS, Khalilov, R, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khang, Y-H, Khater, AM, Khayamzadeh, M, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kopec, JA, Koteeswaran, R, Koul, PA, Koulmane Laxminarayana, SL, Koyanagi, A, Kucuk Bicer, B, Kugbey, N, Kumar, GA, Kumar, N, Kurmi, OP, Kutluk, T, La Vecchia, C, Lami, FH, Landires, I, Lauriola, P, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YH, Leigh, J, Leong, E, Li, J, Li, M-C, Liu, X, Loureiro, JA, Lunevicius, R, Magdy Abd El Razek, M, Majeed, A, Makki, A, Male, S, Malik, AA, Mansournia, MA, Martini, S, Masoumi, SZ, Mathur, P, McKee, M, Mehrotra, R, Mendoza, W, Menezes, RG, Mengesha, EW, Mesregah, MK, Mestrovic, T, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirzaei, H, Mirzaei, HR, Misra, S, Mithra, P, Moghadaszadeh, M, Mohammad, KA, Mohammad, Y, Mohammadi, M, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammed, S, Moka, N, Mokdad, AH, Molokhia, M, Monasta, L, Moni, MA, Moosavi, MA, Moradi, Y, Moraga, P, Morgado-da-Costa, J, Morrison, SD, Mosapour, A, Mubarik, S, Mwanri, L, Nagarajan, AJ, Nagaraju, SP, Nagata, C, Naimzada, MD, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Ndejjo, R, 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Abstract: Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. Evidence Review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). Findings: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low
Published: 2021

9. Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019

Author: Paulson, KR, Kamath, AM, Alam, T, Bienhoff, K, Abady, GG, Abbas, J, Abbasi-Kangevari, M, Abbastabar, H, Abd-Allah, F, Abd-Elsalam, SM, Abdoli, A, Abedi, A, Abolhassani, H, Abreu, LG, Abu-Gharbieh, E, Abu-Rmeileh, NME, Abushouk, A, Adamu, AL, Adebayo, OM, Adegbosin, AE, Adekanmbi, V, Adetokunboh, OO, Adeyinka, DA, Adsuar, JC, Afshari, K, Aghaali, M, Agudelo-Botero, M, Ahinkorah, BO, Ahmad, T, Ahmadi, K, Ahmed, MB, Aji, B, Akalu, Y, Akinyemi, OO, Aklilu, A, Al-Aly, Z, Alam, K, Alanezi, FM, Alanzi, TM, Alcalde-Rabanal, JE, Al-Eyadhy, A, Ali, T, Alicandro, G, Alif, SM, Alipour, V, Alizade, H, Aljunid, SM, Almasi-Hashiani, A, Almasri, NA, Al-Mekhlafi, HM, Alonso, J, Al-Raddadi, RM, Altirkawi, KA, Alumran, AK, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Ameyaw, EK, Amini, S, Amini-Rarani, M, Amit, AML, Amugsi, DA, Ancuceanu, R, Anderlini, D, Andrei, CL, Ansari, F, Ansari-Moghaddam, A, Antonio, CAT, Antriyandarti, E, Anvari, D, Anwer, R, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aripov, T, Arnlov, J, Artanti, KD, Arzani, A, Asaad, M, Asadi-Aliabadi, M, Asadi-Pooya, AA, Jafarabadi, MA, Athari, SS, Athari, SM, Atnafu, DD, Atreya, A, Atteraya, MS, Ausloos, M, Awan, AT, Quintanilla, BPA, Ayano, G, Ayanore, MA, Aynalem, YA, Azari, S, Azarian, G, Azene, ZN, Darshan, BB, Babaee, E, Badiye, AD, Baig, AA, Banach, M, Banik, PC, Barker-Collo, SL, Barqawi, HJ, Bassat, Q, Basu, S, Baune, BT, Bayati, M, Bedi, N, Beghi, E, Beghi, M, Bell, ML, Bendak, S, Bennett, DA, Bensenor, IM, Berhe, K, Berman, AE, Bezabih, YM, Bhagavathula, AS, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhattarai, S, Bhutta, ZA, Bikbov, B, Biondi, A, Birihane, BM, Biswas, RK, Bohlouli, S, Bragazzi, NL, Breusov, A, Brunoni, AR, Burkart, K, Nagaraja, SB, Busse, R, Butt, ZA, dos Santos, FLC, Cahuana-Hurtado, L, Camargos, P, Camera, LA, Cardenas, R, Carreras, G, Carrero, JJ, Carvalho, F, Castaldelli-Maia, JM, Castaneda-Orjuela, CA, Castelpietra, G, Cerin, E, Chang, J-C, Chanie, WF, Charan, J, Chatterjee, S, Chattu, SK, Chattu, VK, Chaturvedi, S, Chen, S, Cho, DY, Choi, J-YJ, Chu, D-T, Ciobanu, LG, Cirillo, M, Conde, J, Costa, VM, Couto, RAS, Dachew, BA, Dahlawi, SMA, Dai, H, Dai, X, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Darmstadt, GL, Das, JK, Davila-Cervantes, CA, Davis, AC, Davletov, K, De la Hoz, FP, De Leo, D, Deeba, F, Denova-Gutierrez, E, Dervenis, N, Desalew, A, Deuba, K, Dey, S, Dharmaratne, SD, Dhingra, S, Dhungana, GP, da Silva, DD, Diaz, D, Dorostkar, F, Doshmangir, L, Dubljanin, E, Duraes, AR, Eagan, AW, Edinur, HA, Efendi, F, Eftekharzadeh, S, El Sayed, I, El Tantawi, M, Elbarazi, I, Elgendy, IY, El-Jaafary, S, Emami, A, Enany, S, Eyawo, O, Ezzikouri, S, Faris, PS, Farzadfar, F, Fattahi, N, Fauk, NK, Fazlzadeh, M, Feigin, VL, Ferede, TY, Fereshtehnejad, S-M, Fernandes, E, Ferrara, P, Filip, I, Fischer, F, Fisher, JL, Foigt, NA, Folayan, MO, Foroutan, M, Franklin, RC, Freitas, M, Friedman, SD, Fukumoto, T, Gad, MM, Gaidhane, AM, Gaidhane, S, Gaihre, S, Gallus, S, Garcia-Basteiro, AL, Garcia-Gordillo, M, Gardner, WM, Fonseca, MG, Gebremedhin, KB, Getacher, L, Ghashghaee, A, Gholamian, A, Gilani, SA, Gill, TK, Giussani, G, Gnedovskaya, E, Godinho, MA, Goel, A, Golechha, M, Gona, PN, Gopalani, SV, Goudarzi, H, Grivna, M, Gugnani, HC, Guido, D, Guimaraes, RA, Das Gupta, R, Gupta, R, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Hamidi, S, Hanif, A, Hankey, GJ, Hargono, A, Hasaballah, A, Hasan, MM, Hasan, SS, Hassan, A, Hassanipour, S, Hassankhani, H, Havmoeller, RJ, Hayat, K, Heidari-Soureshjani, R, Henry, NJ, Herteliu, C, Hole, MK, Holla, R, Hossain, N, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Hwang, B-F, Iavicoli, I, Ibitoye, SE, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Inamdar, S, Inbaraj, LR, Iqbal, K, Iqbal, U, Islam, MM, Shariful Islam, Sheikh, Iso, H, Iwagami, M, Iwu, CCD, Jaafari, J, Jacobsen, KH, Jagnoor, J, Jain, V, Janodia, MD, Javaheri, T, Javanmardi, F, Jayaram, S, Jayatilleke, AU, Jenabi, E, Jha, RP, Ji, JS, John, O, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jozwiak, JJ, Jurisson, M, Kabir, A, Kabir, Z, Kalankesh, LR, Kamyari, N, Kanchan, T, Kapoor, N, Matin, BK, Karch, A, Karimi, SE, Kassahun, G, Kayode, GA, Karyani, AK, Kemmer, L, Khalid, N, Khalilov, R, Khammarnia, M, Khan, EA, Khan, G, Khan, M, Khan, MN, Khang, Y-H, Khatab, K, Khater, AM, Khater, MM, Khayamzadeh, M, Khosravi, A, Kim, D, Kim, Y-E, Kim, YJ, Kimokoti, RW, Kisa, A, Kisa, S, Kissoon, N, Kopec, JA, Kosen, S, Koul, PA, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Defo, BK, Bicer, BK, Kulkarni, V, Kumar, GA, Kumar, M, Kumar, N, Kurmi, OP, Kusuma, D, La Vecchia, C, Lacey, B, Lalloo, R, Lami, FH, Landires, I, Larsson, AO, Lasrado, S, Lassi, ZS, Lauriola, P, Lee, PH, Lee, SWH, Lee, YH, Leigh, J, Leonardi, M, Lewycka, S, Li, B, Li, S, Liang, J, Lim, L-L, Limenih, MA, Lin, R-T, Liu, X, Lodha, R, Lopez, AD, Lozano, R, Lugo, A, Lunevicius, R, Mackay, MT, Kunjathur, SM, Magnani, FG, Prasad, DRM, Maheri, M, Mahmoudi, M, Majeed, A, Maled, V, Maleki, A, Maleki, S, Malekzadeh, R, Malik, AA, Malta, DC, Mamun, AA, Mansouri, B, Mansournia, MA, Martinez, G, Martini, S, Martins-Melo, FR, Masoumi, SZ, Maulik, PK, McAlinden, C, McGrath, JJ, Medina-Solis, CE, Nasab, EM, Mejia-Rodriguez, F, Memish, ZA, Mendoza, W, Menezes, RG, Mengesha, EW, Mensah, GA, Meretoja, A, Meretoja, TJ, Mersha, AM, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mini, GK, Miri, M, Mirica, A, Mirrakhimov, EM, Mirzaei, H, Mirzaei, M, Moazen, B, Moghadaszadeh, M, Mohajer, B, Mohamad, O, Mohammad, Y, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammed, S, Mokdad, AH, Molokhia, M, Monasta, L, Mondello, S, Moni, MA, Moore, CE, Moradi, G, Moradi, M, Moradzadeh, R, Moraga, P, Morawska, L, Morrison, SD, Mosser, JF, Khaneghah, AM, Mustafa, G, Naderi, M, Nagarajan, AJ, Nagaraju, SP, Naghavi, M, Naghshtabrizi, B, Naimzada, MD, Nangia, V, Swamy, SN, Nascimento, BR, Naveed, M, Nazari, J, Ndejjo, R, Negoi, I, Negoi, RI, Nena, E, Nepal, S, Netsere, HB, Nguefack-Tsague, G, Ngunjiri, JW, Chi, TYN, Cuong, TN, Huong, LTN, Nigatu, YT, Nigussie, SN, Nixon, MR, Nnaji, CA, Nomura, S, Noor, NM, Noubiap, JJ, Nunez-Samudio, V, Nwatah, VE, Oancea, B, Odukoya, OO, Ogbo, FA, Olusanya, BO, Olusanya, JO, Bali, AO, Onwujekwe, OE, Ortiz, A, Otoiu, A, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Mahesh, PA, Padubidri, JR, Pakhale, S, Pakshir, K, Pal, PK, Palladino, R, Pana, A, Panda-Jonas, S, Pandey, A, Pandi-Perumal, SR, Pangaribuan, HU, Pardo-Montano, AM, Park, E-K, Patel, SK, Patton, GC, Pawar, S, Toroudi, HP, Peden, AE, Pepito, VCF, Peprah, EK, Pereira, J, Perez-Gomez, J, Perico, N, Pesudovs, K, Pilgrim, T, Pinheiro, M, Piradov, MA, Pirsaheb, M, Platts-Mills, JA, Pokhrel, KN, Postma, MJ, Pourjafar, H, Prada, S, Prakash, S, Pupillo, E, Syed, ZQ, Rabiee, N, Radfar, A, Rafiee, A, Rafiei, A, Raggi, A, Rahimzadeh, S, Rahman, MHU, Rahmani, AM, Ramezanzadeh, K, Rana, J, Ranabhat, CL, Rao, SJ, Rasella, D, Rastogi, P, Rathi, P, Rawaf, DL, Rawaf, S, Rawasia, WF, Rawassizadeh, R, Jr, RCR, Remuzzi, G, Renzaho, AMN, Reshmi, B, Resnikoff, S, Rezaei, N, Rezapour, A, Riahi, SM, Ribeiro, D, Rickard, J, Roever, L, Ronfani, L, Rothenbacher, D, Rubagotti, E, Rumisha, SF, Ryan, PM, Saddik, B, Sadeghi, E, Moghaddam, SS, Sagar, R, Sahebkar, A, Salahshoor, MR, Salehi, S, Salem, MR, Salimzadeh, H, Salomon, JA, Samodra, YL, Samy, AM, Sanabria, J, Santric-Milicevic, MM, Saraswathy, SYI, Sarker, AR, Sarrafzadegan, N, Sarveazad, A, Sathian, B, Sathish, T, Sattin, D, Saxena, S, Saya, GK, Saylan, M, Schiavolin, S, Schlaich, MP, Schwebel, DC, Schwendicke, F, Senthilkumaran, S, Sepanlou, SG, Servan-Mori, E, Sha, F, Shafaat, O, Shahabi, S, Shahbaz, M, Shaheen, AA, Shahid, I, Shaikh, MA, Shakiba, S, Shalash, AS, Shams-Beyranvand, M, Shannawaz, M, Sharafi, K, Sheikh, A, Sheikhbahaei, S, Shiferaw, WS, Shigematsu, M, Shin, JI, Shiri, R, Shiue, I, Shuval, K, Siddiqi, TJ, Sidemo, NB, Sigfusdottir, ID, Sigurvinsdottir, R, Silva, JP, Silverberg, JIS, Simonetti, B, Singh, BB, Singh, JA, Singhal, D, Sinha, DN, Skiadaresi, E, Skryabin, VY, Skryabina, AA, Sleet, DA, Sobaih, BH, Sobhiyeh, MR, Soltani, S, Soriano, JB, Spurlock, EE, Sreeramareddy, CT, Steiropoulos, P, Stokes, Mark, Stortecky, S, Sufiyan, MB, Abdulkader, RS, Sulo, G, Swope, CB, Sykes, BL, Szeto, MD, Szocska, M, Tabares-Seisdedos, R, Tadesse, EG, Taherkhani, A, Tamiru, AT, Tareque, MI, Tehrani-Banihashemi, A, Temsah, M-H, Tesfay, FH, Tessema, GA, Tessema, ZT, Thankappan, KR, Thapar, R, Tolani, MA, Tovani-Palone, MR, Traini, E, Bach, XT, Tripathy, JP, Tsapparellas, G, Tsatsakis, A, Car, LT, Uddin, Riaz, Ullah, A, Umeokonkwo, CD, Unim, B, Unnikrishnan, B, Upadhyay, E, Usman, MS, Vacante, M, Vaezi, M, Tahbaz, SV, Valdez, PR, Vasankari, TJ, Venketasubramanian, N, Verma, M, Violante, FS, Vlassov, V, Vo, B, Giang, TV, Wado, YD, Waheed, Y, Wamai, RG, Wang, Y, Wang, Y-P, Ward, P, Werdecker, A, Westerman, R, Wickramasinghe, ND, Wilner, LB, Wiysonge, CS, Wu, A-M, Wu, C, Xie, Y, Jabbari, SHY, Yamagishi, K, Yandrapalli, S, Yaya, S, Yazdi-Feyzabadi, V, Yip, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yousefi, Z, Yousefinezhadi, T, Yu, C, Yusuf, SS, Zaidi, SS, Bin Zaman, S, Zamani, M, Zamanian, M, Zastrozhin, MS, Zastrozhina, A, Zhang, Y, Zhang, Z-J, Zhao, X-JG, Ziapour, A, Hay, S, Murray, CJL, Wang, H, Kassebaum, NJ, Paulson, KR, Kamath, AM, Alam, T, Bienhoff, K, Abady, GG, Abbas, J, Abbasi-Kangevari, M, Abbastabar, H, Abd-Allah, F, Abd-Elsalam, SM, Abdoli, A, Abedi, A, Abolhassani, H, Abreu, LG, Abu-Gharbieh, E, Abu-Rmeileh, NME, Abushouk, A, Adamu, AL, Adebayo, OM, Adegbosin, AE, Adekanmbi, V, Adetokunboh, OO, Adeyinka, DA, Adsuar, JC, Afshari, K, Aghaali, M, Agudelo-Botero, M, Ahinkorah, BO, Ahmad, T, Ahmadi, K, Ahmed, MB, Aji, B, Akalu, Y, Akinyemi, OO, Aklilu, A, Al-Aly, Z, Alam, K, Alanezi, FM, Alanzi, TM, Alcalde-Rabanal, JE, Al-Eyadhy, A, Ali, T, Alicandro, G, Alif, SM, Alipour, V, Alizade, H, Aljunid, SM, Almasi-Hashiani, A, Almasri, NA, Al-Mekhlafi, HM, Alonso, J, Al-Raddadi, RM, Altirkawi, KA, Alumran, AK, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Ameyaw, EK, Amini, S, Amini-Rarani, M, Amit, AML, Amugsi, DA, Ancuceanu, R, Anderlini, D, Andrei, CL, Ansari, F, Ansari-Moghaddam, A, Antonio, CAT, Antriyandarti, E, Anvari, D, Anwer, R, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aripov, T, Arnlov, J, Artanti, KD, Arzani, A, Asaad, M, Asadi-Aliabadi, M, Asadi-Pooya, AA, Jafarabadi, MA, Athari, SS, Athari, SM, Atnafu, DD, Atreya, A, Atteraya, MS, Ausloos, M, Awan, AT, Quintanilla, BPA, Ayano, G, Ayanore, MA, Aynalem, YA, Azari, S, Azarian, G, Azene, ZN, Darshan, BB, Babaee, E, Badiye, AD, Baig, AA, Banach, M, Banik, PC, Barker-Collo, SL, Barqawi, HJ, Bassat, Q, Basu, S, Baune, BT, Bayati, M, Bedi, N, Beghi, E, Beghi, M, Bell, ML, Bendak, S, Bennett, DA, Bensenor, IM, Berhe, K, Berman, AE, Bezabih, YM, Bhagavathula, AS, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhattarai, S, Bhutta, ZA, Bikbov, B, Biondi, A, Birihane, BM, Biswas, RK, Bohlouli, S, Bragazzi, NL, Breusov, A, Brunoni, AR, Burkart, K, Nagaraja, SB, Busse, R, Butt, ZA, dos Santos, FLC, Cahuana-Hurtado, L, Camargos, P, Camera, LA, Cardenas, R, Carreras, G, Carrero, JJ, Carvalho, F, Castaldelli-Maia, JM, Castaneda-Orjuela, CA, Castelpietra, G, Cerin, E, Chang, J-C, Chanie, WF, Charan, J, Chatterjee, S, Chattu, SK, Chattu, VK, Chaturvedi, S, Chen, S, Cho, DY, Choi, J-YJ, Chu, D-T, Ciobanu, LG, Cirillo, M, Conde, J, Costa, VM, Couto, RAS, Dachew, BA, Dahlawi, SMA, Dai, H, Dai, X, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Darmstadt, GL, Das, JK, Davila-Cervantes, CA, Davis, AC, Davletov, K, De la Hoz, FP, De Leo, D, Deeba, F, Denova-Gutierrez, E, Dervenis, N, Desalew, A, Deuba, K, Dey, S, Dharmaratne, SD, Dhingra, S, Dhungana, GP, da Silva, DD, Diaz, D, Dorostkar, F, Doshmangir, L, Dubljanin, E, Duraes, AR, Eagan, AW, Edinur, HA, Efendi, F, Eftekharzadeh, S, El Sayed, I, El Tantawi, M, Elbarazi, I, Elgendy, IY, El-Jaafary, S, Emami, A, Enany, S, Eyawo, O, Ezzikouri, S, Faris, PS, Farzadfar, F, Fattahi, N, Fauk, NK, Fazlzadeh, M, Feigin, VL, Ferede, TY, Fereshtehnejad, S-M, Fernandes, E, Ferrara, P, Filip, I, Fischer, F, Fisher, JL, Foigt, NA, Folayan, MO, Foroutan, M, Franklin, RC, Freitas, M, Friedman, SD, Fukumoto, T, Gad, MM, Gaidhane, AM, Gaidhane, S, Gaihre, S, Gallus, S, Garcia-Basteiro, AL, Garcia-Gordillo, M, Gardner, WM, Fonseca, MG, Gebremedhin, KB, Getacher, L, Ghashghaee, A, Gholamian, A, Gilani, SA, Gill, TK, Giussani, G, Gnedovskaya, E, Godinho, MA, Goel, A, Golechha, M, Gona, PN, Gopalani, SV, Goudarzi, H, Grivna, M, Gugnani, HC, Guido, D, Guimaraes, RA, Das Gupta, R, Gupta, R, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Hamidi, S, Hanif, A, Hankey, GJ, Hargono, A, Hasaballah, A, Hasan, MM, Hasan, SS, Hassan, A, Hassanipour, S, Hassankhani, H, Havmoeller, RJ, Hayat, K, Heidari-Soureshjani, R, Henry, NJ, Herteliu, C, Hole, MK, Holla, R, Hossain, N, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Hwang, B-F, Iavicoli, I, Ibitoye, SE, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Inamdar, S, Inbaraj, LR, Iqbal, K, Iqbal, U, Islam, MM, Shariful Islam, Sheikh, Iso, H, Iwagami, M, Iwu, CCD, Jaafari, J, Jacobsen, KH, Jagnoor, J, Jain, V, Janodia, MD, Javaheri, T, Javanmardi, F, Jayaram, S, Jayatilleke, AU, Jenabi, E, Jha, RP, Ji, JS, John, O, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jozwiak, JJ, Jurisson, M, Kabir, A, Kabir, Z, Kalankesh, LR, Kamyari, N, Kanchan, T, Kapoor, N, Matin, BK, Karch, A, Karimi, SE, Kassahun, G, Kayode, GA, Karyani, AK, Kemmer, L, Khalid, N, Khalilov, R, Khammarnia, M, Khan, EA, Khan, G, Khan, M, Khan, MN, Khang, Y-H, Khatab, K, Khater, AM, Khater, MM, Khayamzadeh, M, Khosravi, A, Kim, D, Kim, Y-E, Kim, YJ, Kimokoti, RW, Kisa, A, Kisa, S, Kissoon, N, Kopec, JA, Kosen, S, Koul, PA, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Defo, BK, Bicer, BK, Kulkarni, V, Kumar, GA, Kumar, M, Kumar, N, Kurmi, OP, Kusuma, D, La Vecchia, C, Lacey, B, Lalloo, R, Lami, FH, Landires, I, Larsson, AO, Lasrado, S, Lassi, ZS, Lauriola, P, Lee, PH, Lee, SWH, Lee, YH, Leigh, J, Leonardi, M, Lewycka, S, Li, B, Li, S, Liang, J, Lim, L-L, Limenih, MA, Lin, R-T, Liu, X, Lodha, R, Lopez, AD, Lozano, R, Lugo, A, Lunevicius, R, Mackay, MT, Kunjathur, SM, Magnani, FG, Prasad, DRM, Maheri, M, Mahmoudi, M, Majeed, A, Maled, V, Maleki, A, Maleki, S, Malekzadeh, R, Malik, AA, Malta, DC, Mamun, AA, Mansouri, B, Mansournia, MA, Martinez, G, Martini, S, Martins-Melo, FR, Masoumi, SZ, Maulik, PK, McAlinden, C, McGrath, JJ, Medina-Solis, CE, Nasab, EM, Mejia-Rodriguez, F, Memish, ZA, Mendoza, W, Menezes, RG, Mengesha, EW, Mensah, GA, Meretoja, A, Meretoja, TJ, Mersha, AM, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mini, GK, Miri, M, Mirica, A, Mirrakhimov, EM, Mirzaei, H, Mirzaei, M, Moazen, B, Moghadaszadeh, M, Mohajer, B, Mohamad, O, Mohammad, Y, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammed, S, Mokdad, AH, Molokhia, M, Monasta, L, Mondello, S, Moni, MA, Moore, CE, Moradi, G, Moradi, M, Moradzadeh, R, Moraga, P, Morawska, L, Morrison, SD, Mosser, JF, Khaneghah, AM, Mustafa, G, Naderi, M, Nagarajan, AJ, Nagaraju, SP, Naghavi, M, Naghshtabrizi, B, Naimzada, MD, Nangia, V, Swamy, SN, Nascimento, BR, Naveed, M, Nazari, J, Ndejjo, R, Negoi, I, Negoi, RI, Nena, E, Nepal, S, Netsere, HB, Nguefack-Tsague, G, Ngunjiri, JW, Chi, TYN, Cuong, TN, Huong, LTN, Nigatu, YT, Nigussie, SN, Nixon, MR, Nnaji, CA, Nomura, S, Noor, NM, Noubiap, JJ, Nunez-Samudio, V, Nwatah, VE, Oancea, B, Odukoya, OO, Ogbo, FA, Olusanya, BO, Olusanya, JO, Bali, AO, Onwujekwe, OE, Ortiz, A, Otoiu, A, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Mahesh, PA, Padubidri, JR, Pakhale, S, Pakshir, K, Pal, PK, Palladino, R, Pana, A, Panda-Jonas, S, Pandey, A, Pandi-Perumal, SR, Pangaribuan, HU, Pardo-Montano, AM, Park, E-K, Patel, SK, Patton, GC, Pawar, S, Toroudi, HP, Peden, AE, Pepito, VCF, Peprah, EK, Pereira, J, Perez-Gomez, J, Perico, N, Pesudovs, K, Pilgrim, T, Pinheiro, M, Piradov, MA, Pirsaheb, M, Platts-Mills, JA, Pokhrel, KN, Postma, MJ, Pourjafar, H, Prada, S, Prakash, S, Pupillo, E, Syed, ZQ, Rabiee, N, Radfar, A, Rafiee, A, Rafiei, A, Raggi, A, Rahimzadeh, S, Rahman, MHU, Rahmani, AM, Ramezanzadeh, K, Rana, J, Ranabhat, CL, Rao, SJ, Rasella, D, Rastogi, P, Rathi, P, Rawaf, DL, Rawaf, S, Rawasia, WF, Rawassizadeh, R, Jr, RCR, Remuzzi, G, Renzaho, AMN, Reshmi, B, Resnikoff, S, Rezaei, N, Rezapour, A, Riahi, SM, Ribeiro, D, Rickard, J, Roever, L, Ronfani, L, Rothenbacher, D, Rubagotti, E, Rumisha, SF, Ryan, PM, Saddik, B, Sadeghi, E, Moghaddam, SS, Sagar, R, Sahebkar, A, Salahshoor, MR, Salehi, S, Salem, MR, Salimzadeh, H, Salomon, JA, Samodra, YL, Samy, AM, Sanabria, J, Santric-Milicevic, MM, Saraswathy, SYI, Sarker, AR, Sarrafzadegan, N, Sarveazad, A, Sathian, B, Sathish, T, Sattin, D, Saxena, S, Saya, GK, Saylan, M, Schiavolin, S, Schlaich, MP, Schwebel, DC, Schwendicke, F, Senthilkumaran, S, Sepanlou, SG, Servan-Mori, E, Sha, F, Shafaat, O, Shahabi, S, Shahbaz, M, Shaheen, AA, Shahid, I, Shaikh, MA, Shakiba, S, Shalash, AS, Shams-Beyranvand, M, Shannawaz, M, Sharafi, K, Sheikh, A, Sheikhbahaei, S, Shiferaw, WS, Shigematsu, M, Shin, JI, Shiri, R, Shiue, I, Shuval, K, Siddiqi, TJ, Sidemo, NB, Sigfusdottir, ID, Sigurvinsdottir, R, Silva, JP, Silverberg, JIS, Simonetti, B, Singh, BB, Singh, JA, Singhal, D, Sinha, DN, Skiadaresi, E, Skryabin, VY, Skryabina, AA, Sleet, DA, Sobaih, BH, Sobhiyeh, MR, Soltani, S, Soriano, JB, Spurlock, EE, Sreeramareddy, CT, Steiropoulos, P, Stokes, Mark, Stortecky, S, Sufiyan, MB, Abdulkader, RS, Sulo, G, Swope, CB, Sykes, BL, Szeto, MD, Szocska, M, Tabares-Seisdedos, R, Tadesse, EG, Taherkhani, A, Tamiru, AT, Tareque, MI, Tehrani-Banihashemi, A, Temsah, M-H, Tesfay, FH, Tessema, GA, Tessema, ZT, Thankappan, KR, Thapar, R, Tolani, MA, Tovani-Palone, MR, Traini, E, Bach, XT, Tripathy, JP, Tsapparellas, G, Tsatsakis, A, Car, LT, Uddin, Riaz, Ullah, A, Umeokonkwo, CD, Unim, B, Unnikrishnan, B, Upadhyay, E, Usman, MS, Vacante, M, Vaezi, M, Tahbaz, SV, Valdez, PR, Vasankari, TJ, Venketasubramanian, N, Verma, M, Violante, FS, Vlassov, V, Vo, B, Giang, TV, Wado, YD, Waheed, Y, Wamai, RG, Wang, Y, Wang, Y-P, Ward, P, Werdecker, A, Westerman, R, Wickramasinghe, ND, Wilner, LB, Wiysonge, CS, Wu, A-M, Wu, C, Xie, Y, Jabbari, SHY, Yamagishi, K, Yandrapalli, S, Yaya, S, Yazdi-Feyzabadi, V, Yip, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yousefi, Z, Yousefinezhadi, T, Yu, C, Yusuf, SS, Zaidi, SS, Bin Zaman, S, Zamani, M, Zamanian, M, Zastrozhin, MS, Zastrozhina, A, Zhang, Y, Zhang, Z-J, Zhao, X-JG, Ziapour, A, Hay, S, Murray, CJL, Wang, H, and Kassebaum, NJ
Published: 2021

10. Hearing loss prevalence and years lived with disability, 1990–2019: findings from the Global Burden of Disease Study 2019

Author: Haile, LM, Kamenov, K, Briant, PS, Orji, AU, Steinmetz, JD, Abdoli, A, Abdollahi, M, Abu-Gharbieh, E, Afshin, A, Ahmed, H, Ahmed Rashid, T, Akalu, Y, Alahdab, F, Alanezi, FM, Alanzi, TM, Al Hamad, H, Ali, L, Alipour, V, Al-Raddadi, RM, Amu, H, Arabloo, J, Arab-Zozani, M, Arulappan, J, Ashbaugh, C, Atnafu, DD, Babar, ZUD, Baig, AA, Banik, PC, Bärnighausen, TW, Barrow, A, Bender, RG, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bibi, S, Bijani, A, Burkart, K, Cederroth, CR, Charan, J, Choudhari, SG, Chu, DT, Couto, RAS, Dagnew, AB, Dagnew, B, Dahlawi, SMA, Dai, X, Dandona, L, Dandona, R, Desalew, A, Dhamnetiya, D, Dhimal, ML, Dhimal, M, Doyle, KE, Duncan, BB, Ekholuenetale, M, Filip, I, Fischer, F, Franklin, RC, Gaidhane, AM, Gaidhane, S, Gallus, S, Ghamari, F, Ghashghaee, A, Ghozali, G, Gilani, SA, Glavan, IR, Golechha, M, Goulart, BNG, Gupta, VB, Gupta, VK, Hamidi, S, Hammond, BR, Hay, SI, Hayat, K, Heidari, G, Hoffman, HJ, Hopf, KP, Hosseinzadeh, M, Househ, M, Hussain, R, Hwang, BF, Iavicoli, I, Ibitoye, SE, Ilesanmi, OS, Irvani, SSN, Shariful Islam, Sheikh, Iwagami, M, Jacob, L, Jayapal, SK, Jha, RP, Jonas, JB, Kalhor, R, Kameran Al-Salihi, N, Kandel, H, Kasa, AS, Kayode, GA, Khalilov, R, Khan, EA, Khatib, MN, Kosen, S, Haile, LM, Kamenov, K, Briant, PS, Orji, AU, Steinmetz, JD, Abdoli, A, Abdollahi, M, Abu-Gharbieh, E, Afshin, A, Ahmed, H, Ahmed Rashid, T, Akalu, Y, Alahdab, F, Alanezi, FM, Alanzi, TM, Al Hamad, H, Ali, L, Alipour, V, Al-Raddadi, RM, Amu, H, Arabloo, J, Arab-Zozani, M, Arulappan, J, Ashbaugh, C, Atnafu, DD, Babar, ZUD, Baig, AA, Banik, PC, Bärnighausen, TW, Barrow, A, Bender, RG, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bibi, S, Bijani, A, Burkart, K, Cederroth, CR, Charan, J, Choudhari, SG, Chu, DT, Couto, RAS, Dagnew, AB, Dagnew, B, Dahlawi, SMA, Dai, X, Dandona, L, Dandona, R, Desalew, A, Dhamnetiya, D, Dhimal, ML, Dhimal, M, Doyle, KE, Duncan, BB, Ekholuenetale, M, Filip, I, Fischer, F, Franklin, RC, Gaidhane, AM, Gaidhane, S, Gallus, S, Ghamari, F, Ghashghaee, A, Ghozali, G, Gilani, SA, Glavan, IR, Golechha, M, Goulart, BNG, Gupta, VB, Gupta, VK, Hamidi, S, Hammond, BR, Hay, SI, Hayat, K, Heidari, G, Hoffman, HJ, Hopf, KP, Hosseinzadeh, M, Househ, M, Hussain, R, Hwang, BF, Iavicoli, I, Ibitoye, SE, Ilesanmi, OS, Irvani, SSN, Shariful Islam, Sheikh, Iwagami, M, Jacob, L, Jayapal, SK, Jha, RP, Jonas, JB, Kalhor, R, Kameran Al-Salihi, N, Kandel, H, Kasa, AS, Kayode, GA, Khalilov, R, Khan, EA, Khatib, MN, and Kosen, S
Published: 2021

11. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: The Right to Sight: An analysis for the Global Burden of Disease Study

Author: Bourne, RRA, Steinmetz, JD, Saylan, M, Mersha, AM, Weldemariam, AH, Wondmeneh, TG, Sreeramareddy, CT, Pinheiro, M, Yaseri, M, Yu, C, Zastrozhin, MS, Zastrozhina, A, Zhang, ZJ, Zimsen, SRM, Yonemoto, N, Tsegaye, GW, Vu, GT, Vongpradith, A, Renzaho, AMN, Sorrie, MB, Shaheen, AA, Shiferaw, WS, Skryabin, VY, Skryabina, AA, Saya, GK, Rahimi-Movaghar, V, Shigematsu, M, Sahraian, MA, Naderifar, H, Sabour, S, Rathi, P, Sathian, B, Miller, TR, Rezapour, A, Rawal, L, Pham, HQ, Parekh, U, Podder, V, Onwujekwe, OE, Pasovic, M, Otstavnov, N, Negash, H, Pawar, S, Naimzada, MD, Al Montasir, A, Ogbo, FA, Owolabi, MO, Pakshir, K, Mohammad, Y, Moni, MA, Nunez-Samudio, V, Mulaw, GF, Naveed, M, Maleki, S, Michalek, IM, Misra, S, Swamy, SN, Mohammed, JA, Flaxman, S, Park, EC, Briant, PS, Meles, GG, Hayat, K, Landires, I, Kim, GR, Liu, X, LeGrand, KE, Taylor, HR, Kunjathur, SM, Khoja, TAM, Bicer, BK, Khalilov, R, Hashi, A, Kayode, GA, Carneiro, VLA, Kavetskyy, T, Kosen, S, Kulkarni, V, Holla, R, Kalhor, R, Jayaram, S, Islam, Shariful, Gilani, SA, Eskandarieh, S, Molla, MD, Itumalla, R, Farzadfar, F, Congdon, NG, Elhabashy, HR, Elayedath, R, Couto, RAS, Dervenis, N, Cromwell, EA, Dahlawi, SMA, Resnikoff, S, Casson, RJ, Abdoli, A, Choi, JYJ, Dos Santos, FLC, Abrha, WA, Bourne, RRA, Steinmetz, JD, Saylan, M, Mersha, AM, Weldemariam, AH, Wondmeneh, TG, Sreeramareddy, CT, Pinheiro, M, Yaseri, M, Yu, C, Zastrozhin, MS, Zastrozhina, A, Zhang, ZJ, Zimsen, SRM, Yonemoto, N, Tsegaye, GW, Vu, GT, Vongpradith, A, Renzaho, AMN, Sorrie, MB, Shaheen, AA, Shiferaw, WS, Skryabin, VY, Skryabina, AA, Saya, GK, Rahimi-Movaghar, V, Shigematsu, M, Sahraian, MA, Naderifar, H, Sabour, S, Rathi, P, Sathian, B, Miller, TR, Rezapour, A, Rawal, L, Pham, HQ, Parekh, U, Podder, V, Onwujekwe, OE, Pasovic, M, Otstavnov, N, Negash, H, Pawar, S, Naimzada, MD, Al Montasir, A, Ogbo, FA, Owolabi, MO, Pakshir, K, Mohammad, Y, Moni, MA, Nunez-Samudio, V, Mulaw, GF, Naveed, M, Maleki, S, Michalek, IM, Misra, S, Swamy, SN, Mohammed, JA, Flaxman, S, Park, EC, Briant, PS, Meles, GG, Hayat, K, Landires, I, Kim, GR, Liu, X, LeGrand, KE, Taylor, HR, Kunjathur, SM, Khoja, TAM, Bicer, BK, Khalilov, R, Hashi, A, Kayode, GA, Carneiro, VLA, Kavetskyy, T, Kosen, S, Kulkarni, V, Holla, R, Kalhor, R, Jayaram, S, Islam, Shariful, Gilani, SA, Eskandarieh, S, Molla, MD, Itumalla, R, Farzadfar, F, Congdon, NG, Elhabashy, HR, Elayedath, R, Couto, RAS, Dervenis, N, Cromwell, EA, Dahlawi, SMA, Resnikoff, S, Casson, RJ, Abdoli, A, Choi, JYJ, Dos Santos, FLC, and Abrha, WA
Published: 2021

12. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Author: Feigin, VL, Stark, BA, Johnson, CO, Roth, GA, Bisignano, C, Abady, GG, Abbasifard, M, Abbasi-Kangevari, M, Abd-Allah, F, Abedi, V, Abualhasan, A, Abu-Rmeileh, NM, Abushouk, A, Adebayo, OM, Agarwal, G, Agasthi, P, Ahinkorah, BO, Ahmad, S, Ahmadi, S, Salih, YA, Aji, B, Akbarpour, S, Akinyemi, RO, Al Hamad, H, Alahdab, F, Alif, SM, Alipour, V, Aljunid, SM, Almustanyir, S, Al-Raddadi, RM, Salman, RA-S, Alvis-Guzman, N, Ancuceanu, R, Anderlini, D, Anderson, JA, Ansar, A, Antonazzo, IC, Arabloo, J, Arnlov, J, Artanti, KD, Aryan, Z, Asgari, S, Ashraf, T, Athar, M, Atreya, A, Ausloos, M, Baig, AA, Baltatu, OC, Banach, M, Barboza, MA, Barker-Collo, SL, Barnighausen, TW, Barone, MTU, Basu, S, Bazmandegan, G, Beghi, E, Beheshti, M, Bejot, Y, Bell, AW, Bennett, DA, Bensenor, IM, Bezabhe, WM, Bezabih, YM, Bhagavathula, AS, Bhardwaj, P, Bhattacharyya, K, Bijani, A, Bikbov, B, Birhanu, MM, Boloor, A, Bonny, A, Brauer, M, Brenner, H, Bryazka, D, Butt, ZA, dos Santos, FLC, Campos-Nonato, IR, Cantu-Brito, C, Carrero, JJ, Castaneda-Orjuela, CA, Catapano, AL, Chakraborty, PA, Charan, J, Choudhari, SG, Chowdhury, EK, Chu, D-T, Chung, S-C, Colozza, D, Costa, VM, Costanzo, S, Criqui, MH, Dadras, O, Dagnew, B, Dai, X, Dalal, K, Damasceno, AAM, D'Amico, E, Dandona, L, Dandona, R, Gela, JD, Davletov, K, De La Cruz-Gongora, V, Desai, R, Dhamnetiya, D, Dharmaratne, SD, Dhimal, ML, Dhimal, M, Diaz, D, Dichgans, M, Dokova, K, Doshi, R, Douiri, A, Duncan, BB, Eftekharzadeh, S, Ekholuenetale, M, El Nahas, N, Elgendy, IY, Elhadi, M, El-Jaafary, S, Endres, M, Endries, AY, Erku, DA, Faraon, EJA, Farooque, U, Farzadfar, F, Feroze, AH, Filip, I, Fischer, F, Flood, D, Gad, MM, Gaidhane, S, Gheshlagh, RG, Ghashghaee, A, Ghith, N, Ghozali, G, Ghozy, S, Gialluisi, A, Giampaoli, S, Gilani, SA, Gill, PS, Gnedovskaya, E, Golechha, M, Goulart, AC, Guo, Y, Gupta, R, Gupta, VB, Gupta, VK, Gyanwali, P, Hafezi-Nejad, N, Hamidi, S, Hanif, A, Hankey, GJ, Hargono, A, Hashi, A, Hassan, TS, Hassen, HY, Havmoeller, RJ, Hay, S, Hayat, K, Hegazy, M, Herteliu, C, Holla, R, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Hwang, B-F, Iacoviello, L, Iavicoli, I, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Iqbal, U, Irvani, SSN, Islam, SMS, Ismail, NE, Iso, H, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jang, S-I, Jayapal, SK, Jayaram, S, Jayawardena, R, Jeemon, P, Jha, RP, Johnson, WD, Jonas, JB, Joseph, N, Jozwiak, JJ, Jurisson, M, Kalani, R, Kalhor, R, Kalkonde, Y, Kamath, A, Kamiab, Z, Kanchan, T, Kandel, H, Karch, A, Katoto, PDMC, Kayode, GA, Keshavarz, P, Khader, YS, Khan, EA, Khan, IA, Khan, M, Khan, MAB, Khatib, MN, Khubchandani, J, Kim, GR, Kim, MS, Kim, YJ, Kisa, A, Kisa, S, Kivimaki, M, Kolte, D, Koolivand, A, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Krishnamurthi, R, Kumar, GA, Kusuma, D, La Vecchia, C, Lacey, B, Lak, HM, Lallukka, T, Lasrado, S, Lavados, PM, Leonardi, M, Li, B, Li, S, Lin, H, Lin, R-T, Liu, X, Lo, WD, Lorkowski, S, Lucchetti, G, Saute, RL, Razek, HMAE, Magnani, FG, Mahajan, PB, Majeed, A, Makki, A, Malekzadeh, R, Malik, AA, Manafi, N, Mansournia, MA, Mantovani, LG, Martini, S, Mazzaglia, G, Mehndiratta, MM, Menezes, RG, Meretoja, A, Mersha, AG, Jonasson, JM, Miazgowski, B, Miazgowski, T, Michalek, IM, Mirrakhimov, EM, Mohammad, Y, Mohammadian-Hafshejani, A, Mohammed, S, Mokdad, AH, Mokhayeri, Y, Molokhia, M, Moni, MA, Al Montasir, A, Moradzadeh, R, Morawska, L, Morze, J, Muruet, W, Musa, KI, Nagarajan, AJ, Naghavi, M, Swamy, SN, Nascimento, BR, Negoi, RI, Kandel, SN, Trang, HN, Norrving, B, Noubiap, JJ, Nwatah, VE, Oancea, B, Odukoya, OO, Olagunju, AT, Orru, H, Owolabi, MO, Padubidri, JR, Pana, A, Parekh, T, Park, E-C, Kan, FP, Pathak, M, Peres, MFP, Perianayagam, A, Truong-Minh, P, Piradov, MA, Podder, V, Polinder, S, Postma, MJ, Pourshams, A, Radfar, A, Rafiei, A, Raggi, A, Rahim, F, Rahimi-Movaghar, V, Rahman, M, Rahman, MA, Rahmani, AM, Rajai, N, Ranasinghe, P, Rao, CR, Rao, SJ, Rathi, P, Rawaf, DL, Rawaf, S, Reitsma, MB, Renjith, V, Renzaho, AMN, Rezapour, A, Rodriguez, JAB, Roever, L, Romoli, M, Rynkiewicz, A, Sacco, S, Sadeghi, M, Moghaddam, SS, Sahebkar, A, Saif-Ur-Rahman, K, Salah, R, Samaei, M, Samy, AM, Santos, IS, Santric-Milicevic, MM, Sarrafzadegan, N, Sathian, B, Sattin, D, Schiavolin, S, Schlaich, MP, Schmidt, MI, Schutte, AE, Sepanlou, SG, Seylani, A, Sha, F, Shahabi, S, Shaikh, MA, Shannawaz, M, Shawon, MSR, Sheikh, A, Sheikhbahaei, S, Shibuya, K, Siabani, S, Silva, DAS, Singh, JA, Singh, JK, Skryabin, VY, Skryabina, AA, Sobaih, BH, Stortecky, S, Stranges, S, Tadesse, EG, Tarigan, IU, Temsah, M-H, Teuschl, Y, Thrift, AG, Tonelli, M, Tovani-Palone, MR, Bach, XT, Tripathi, M, Tsegaye, GW, Ullah, A, Unim, B, Unnikrishnan, B, Vakilian, A, Tahbaz, SV, Vasankari, TJ, Venketasubramanian, N, Vervoort, D, Vo, B, Volovici, V, Vosoughi, K, Giang, TV, Linh, GV, Wafa, HA, Waheed, Y, Wang, Y, Wijeratne, T, Winkler, AS, Wolfe, CDA, Woodward, M, Wu, JH, Hanson, SW, Xu, X, Yadav, L, Yadollahpour, A, Jabbari, SHY, Yamagishi, K, Yatsuya, H, Yonemoto, N, Yu, C, Yunusa, I, Zaman, MS, Bin Zaman, S, Zamanian, M, Zand, R, Zandifar, A, Zastrozhin, MS, Zastrozhina, A, Zhang, Y, Zhang, Z-J, Zhong, C, Zuniga, YMH, Murray, CJL, Feigin, VL, Stark, BA, Johnson, CO, Roth, GA, Bisignano, C, Abady, GG, Abbasifard, M, Abbasi-Kangevari, M, Abd-Allah, F, Abedi, V, Abualhasan, A, Abu-Rmeileh, NM, Abushouk, A, Adebayo, OM, Agarwal, G, Agasthi, P, Ahinkorah, BO, Ahmad, S, Ahmadi, S, Salih, YA, Aji, B, Akbarpour, S, Akinyemi, RO, Al Hamad, H, Alahdab, F, Alif, SM, Alipour, V, Aljunid, SM, Almustanyir, S, Al-Raddadi, RM, Salman, RA-S, Alvis-Guzman, N, Ancuceanu, R, Anderlini, D, Anderson, JA, Ansar, A, Antonazzo, IC, Arabloo, J, Arnlov, J, Artanti, KD, Aryan, Z, Asgari, S, Ashraf, T, Athar, M, Atreya, A, Ausloos, M, Baig, AA, Baltatu, OC, Banach, M, Barboza, MA, Barker-Collo, SL, Barnighausen, TW, Barone, MTU, Basu, S, Bazmandegan, G, Beghi, E, Beheshti, M, Bejot, Y, Bell, AW, Bennett, DA, Bensenor, IM, Bezabhe, WM, Bezabih, YM, Bhagavathula, AS, Bhardwaj, P, Bhattacharyya, K, Bijani, A, Bikbov, B, Birhanu, MM, Boloor, A, Bonny, A, Brauer, M, Brenner, H, Bryazka, D, Butt, ZA, dos Santos, FLC, Campos-Nonato, IR, Cantu-Brito, C, Carrero, JJ, Castaneda-Orjuela, CA, Catapano, AL, Chakraborty, PA, Charan, J, Choudhari, SG, Chowdhury, EK, Chu, D-T, Chung, S-C, Colozza, D, Costa, VM, Costanzo, S, Criqui, MH, Dadras, O, Dagnew, B, Dai, X, Dalal, K, Damasceno, AAM, D'Amico, E, Dandona, L, Dandona, R, Gela, JD, Davletov, K, De La Cruz-Gongora, V, Desai, R, Dhamnetiya, D, Dharmaratne, SD, Dhimal, ML, Dhimal, M, Diaz, D, Dichgans, M, Dokova, K, Doshi, R, Douiri, A, Duncan, BB, Eftekharzadeh, S, Ekholuenetale, M, El Nahas, N, Elgendy, IY, Elhadi, M, El-Jaafary, S, Endres, M, Endries, AY, Erku, DA, Faraon, EJA, Farooque, U, Farzadfar, F, Feroze, AH, Filip, I, Fischer, F, Flood, D, Gad, MM, Gaidhane, S, Gheshlagh, RG, Ghashghaee, A, Ghith, N, Ghozali, G, Ghozy, S, Gialluisi, A, Giampaoli, S, Gilani, SA, Gill, PS, Gnedovskaya, E, Golechha, M, Goulart, AC, Guo, Y, Gupta, R, Gupta, VB, Gupta, VK, Gyanwali, P, Hafezi-Nejad, N, Hamidi, S, Hanif, A, Hankey, GJ, Hargono, A, Hashi, A, Hassan, TS, Hassen, HY, Havmoeller, RJ, Hay, S, Hayat, K, Hegazy, M, Herteliu, C, Holla, R, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Hwang, B-F, Iacoviello, L, Iavicoli, I, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Iqbal, U, Irvani, SSN, Islam, SMS, Ismail, NE, Iso, H, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jang, S-I, Jayapal, SK, Jayaram, S, Jayawardena, R, Jeemon, P, Jha, RP, Johnson, WD, Jonas, JB, Joseph, N, Jozwiak, JJ, Jurisson, M, Kalani, R, Kalhor, R, Kalkonde, Y, Kamath, A, Kamiab, Z, Kanchan, T, Kandel, H, Karch, A, Katoto, PDMC, Kayode, GA, Keshavarz, P, Khader, YS, Khan, EA, Khan, IA, Khan, M, Khan, MAB, Khatib, MN, Khubchandani, J, Kim, GR, Kim, MS, Kim, YJ, Kisa, A, Kisa, S, Kivimaki, M, Kolte, D, Koolivand, A, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Krishnamurthi, R, Kumar, GA, Kusuma, D, La Vecchia, C, Lacey, B, Lak, HM, Lallukka, T, Lasrado, S, Lavados, PM, Leonardi, M, Li, B, Li, S, Lin, H, Lin, R-T, Liu, X, Lo, WD, Lorkowski, S, Lucchetti, G, Saute, RL, Razek, HMAE, Magnani, FG, Mahajan, PB, Majeed, A, Makki, A, Malekzadeh, R, Malik, AA, Manafi, N, Mansournia, MA, Mantovani, LG, Martini, S, Mazzaglia, G, Mehndiratta, MM, Menezes, RG, Meretoja, A, Mersha, AG, Jonasson, JM, Miazgowski, B, Miazgowski, T, Michalek, IM, Mirrakhimov, EM, Mohammad, Y, Mohammadian-Hafshejani, A, Mohammed, S, Mokdad, AH, Mokhayeri, Y, Molokhia, M, Moni, MA, Al Montasir, A, Moradzadeh, R, Morawska, L, Morze, J, Muruet, W, Musa, KI, Nagarajan, AJ, Naghavi, M, Swamy, SN, Nascimento, BR, Negoi, RI, Kandel, SN, Trang, HN, Norrving, B, Noubiap, JJ, Nwatah, VE, Oancea, B, Odukoya, OO, Olagunju, AT, Orru, H, Owolabi, MO, Padubidri, JR, Pana, A, Parekh, T, Park, E-C, Kan, FP, Pathak, M, Peres, MFP, Perianayagam, A, Truong-Minh, P, Piradov, MA, Podder, V, Polinder, S, Postma, MJ, Pourshams, A, Radfar, A, Rafiei, A, Raggi, A, Rahim, F, Rahimi-Movaghar, V, Rahman, M, Rahman, MA, Rahmani, AM, Rajai, N, Ranasinghe, P, Rao, CR, Rao, SJ, Rathi, P, Rawaf, DL, Rawaf, S, Reitsma, MB, Renjith, V, Renzaho, AMN, Rezapour, A, Rodriguez, JAB, Roever, L, Romoli, M, Rynkiewicz, A, Sacco, S, Sadeghi, M, Moghaddam, SS, Sahebkar, A, Saif-Ur-Rahman, K, Salah, R, Samaei, M, Samy, AM, Santos, IS, Santric-Milicevic, MM, Sarrafzadegan, N, Sathian, B, Sattin, D, Schiavolin, S, Schlaich, MP, Schmidt, MI, Schutte, AE, Sepanlou, SG, Seylani, A, Sha, F, Shahabi, S, Shaikh, MA, Shannawaz, M, Shawon, MSR, Sheikh, A, Sheikhbahaei, S, Shibuya, K, Siabani, S, Silva, DAS, Singh, JA, Singh, JK, Skryabin, VY, Skryabina, AA, Sobaih, BH, Stortecky, S, Stranges, S, Tadesse, EG, Tarigan, IU, Temsah, M-H, Teuschl, Y, Thrift, AG, Tonelli, M, Tovani-Palone, MR, Bach, XT, Tripathi, M, Tsegaye, GW, Ullah, A, Unim, B, Unnikrishnan, B, Vakilian, A, Tahbaz, SV, Vasankari, TJ, Venketasubramanian, N, Vervoort, D, Vo, B, Volovici, V, Vosoughi, K, Giang, TV, Linh, GV, Wafa, HA, Waheed, Y, Wang, Y, Wijeratne, T, Winkler, AS, Wolfe, CDA, Woodward, M, Wu, JH, Hanson, SW, Xu, X, Yadav, L, Yadollahpour, A, Jabbari, SHY, Yamagishi, K, Yatsuya, H, Yonemoto, N, Yu, C, Yunusa, I, Zaman, MS, Bin Zaman, S, Zamanian, M, Zand, R, Zandifar, A, Zastrozhin, MS, Zastrozhina, A, Zhang, Y, Zhang, Z-J, Zhong, C, Zuniga, YMH, and Murray, CJL
Abstract: BACKGROUND: Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. METHODS: We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. FINDINGS: In 2019, there were 12·2 million (95% UI 11·0-13·6) incident cases of stroke, 101 million (93·2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6·55 million (6·00-7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8-12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1-6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0-73·0), prevalent strokes increased by 85·0% (83·0-88·0), deaths from stroke increased by 43·0% (31·0-55·0), and DALYs due to stroke increased by 32·0% (22·0-42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0-18·0), mortality decreased by 36·0% (31·0-42·0), prevalence decreased by 6·0% (5·0-7·0), and DALYs decreased by 36·0% (31·0-42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0-24·0) and incidence rat
Published: 2021

13. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study

Author: Steinmetz, JD, Bourne, RRA, Briant, PS, Flaxman, S, Taylor, HR, Jonas, JB, Abdoli, A, Abrha, WA, Abualhasan, A, Abu-Gharbieh, E, Adal, TG, Afshin, A, Ahmadieh, H, Alemayehu, W, Alemzadeh, SA, Alfaar, AS, Alipour, V, Androudi, S, Arabloo, J, Arditi, A, Aregawi, BB, Arrigo, A, Ashbaugh, C, Ashrafi, E, Atnafu, DD, Bagli, E, Baig, AA, Barnighausen, TW, Parodi, MB, Beheshti, M, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bijani, A, Bikbov, M, Bottone, M, Braithwaite, T, Bron, AM, Nagaraja, SB, Butt, ZA, dos Santos, FLC, Carneiro, VLA, Casson, RJ, Cheng, C-Y, Choi, J-YJ, Chu, D-T, Cicinelli, MV, Coelho, JM, Congdon, NG, Couto, RAS, Cromwell, EA, Dahlawi, SMA, Dai, X, Dana, R, Dandona, L, Dandona, R, Del Monte, MA, Molla, MD, Dervenis, N, Desta, AA, Deva, JP, Diaz, D, Djalalinia, S, Ehrlich, JR, Elayedath, R, Elhabashy, HR, Ellwein, LB, Emamian, MH, Eskandarieh, S, Farzadfar, F, Fernandes, AG, Fischer, F, Friedman, DS, Furtado, JM, Gaidhane, S, Gazzard, G, Gebremichael, B, George, R, Ghashghaee, A, Gilani, SA, Golechha, M, Hamidi, S, Hammond, BR, Hartnett, MER, Hartono, RK, Hashi, A, Hay, S, Hayat, K, Heidari, G, Ho, HC, Holla, R, Househ, M, Huang, JJ, Ibitoye, SE, Ilic, IM, Ilic, MD, Ingram, AD, Irvani, SSN, Islam, SMS, Itumalla, R, Jayaram, S, Jha, RP, Kahloun, R, Kalhor, R, Kandel, H, Kasa, AS, Kavetskyy, T, Kayode, GA, Kempen, JH, Khairallah, M, Khalilov, R, Khan, EA, Khanna, RC, Khatib, MN, Khoja, TAM, Kim, GR, Kim, JE, Kim, YJ, Kisa, A, Kisa, S, Kosen, S, Koyanagi, A, Bicer, BK, Kulkarni, V, Kurmi, OP, Landires, I, Lansingh, VC, Leasher, JL, LeGrand, KE, Leveziel, N, Limburg, H, Liu, X, Kunjathur, SM, Maleki, S, Manafi, N, Mansouri, K, McAlinden, C, Meles, GG, Mersha, AM, Michalek, IM, Miller, TR, Misra, S, Mohammad, Y, Mohammadi, SF, Mohammed, JA, Mokdad, AH, Moni, MA, Al Montasir, A, Morse, AR, Mulaw, GF, Naderi, M, Naderifar, H, Naidoo, KS, Naimzada, MD, Nangia, V, Swamy, SN, Naveed, M, Negash, H, Huong, LTN, Nunez-Samudio, V, Ogbo, FA, Ogundimu, K, Olagunju, AT, Onwujekwe, OE, Otstavnov, N, Owolabi, MO, Pakshir, K, Panda-Jonas, S, Parekh, U, Park, E-C, Pasovic, M, Pawar, S, Pesudovs, K, Peto, T, Pham, HQ, Pinheiro, M, Podder, V, Rahimi-Movaghar, V, Rahman, MHU, Ramulu, PY, Rathi, P, Rawaf, DL, Rawaf, S, Rawal, L, Reinig, N, Renzaho, AMN, Rezapour, A, Robin, AL, Rossetti, L, Sabour, S, Safi, S, Sahebkar, A, Sahraian, MA, Samy, AM, Sathian, B, Saya, GK, Saylan, M, Shaheen, AA, Shaikh, MA, Shen, TT, Shibuya, K, Shiferaw, WS, Shigematsu, M, Shin, JI, Silva, JC, Silvester, A, Singh, JA, Singhal, D, Sitorus, RS, Skiadaresi, E, Skryabin, VY, Skryabina, AA, Soheili, A, Sorrie, MB, Sousa, RARC, Sreeramareddy, CT, Stambolian, D, Tadesse, EG, Tahhan, N, Tareque, MI, Topouzis, F, Bach, XT, Tsegaye, GW, Tsilimbaris, MK, Varma, R, Virgili, G, Vongpradith, A, Vu, GT, Wang, YX, Wang, N, Weldemariam, AH, West, SK, Wondmeneh, TG, Wong, TY, Yaseri, M, Yonemoto, N, Yu, C, Zastrozhin, MS, Zastrozhina, A, Zhang, Z-J, Zimsen, SRM, Resnikoff, S, Vos, T, Steinmetz, JD, Bourne, RRA, Briant, PS, Flaxman, S, Taylor, HR, Jonas, JB, Abdoli, A, Abrha, WA, Abualhasan, A, Abu-Gharbieh, E, Adal, TG, Afshin, A, Ahmadieh, H, Alemayehu, W, Alemzadeh, SA, Alfaar, AS, Alipour, V, Androudi, S, Arabloo, J, Arditi, A, Aregawi, BB, Arrigo, A, Ashbaugh, C, Ashrafi, E, Atnafu, DD, Bagli, E, Baig, AA, Barnighausen, TW, Parodi, MB, Beheshti, M, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bijani, A, Bikbov, M, Bottone, M, Braithwaite, T, Bron, AM, Nagaraja, SB, Butt, ZA, dos Santos, FLC, Carneiro, VLA, Casson, RJ, Cheng, C-Y, Choi, J-YJ, Chu, D-T, Cicinelli, MV, Coelho, JM, Congdon, NG, Couto, RAS, Cromwell, EA, Dahlawi, SMA, Dai, X, Dana, R, Dandona, L, Dandona, R, Del Monte, MA, Molla, MD, Dervenis, N, Desta, AA, Deva, JP, Diaz, D, Djalalinia, S, Ehrlich, JR, Elayedath, R, Elhabashy, HR, Ellwein, LB, Emamian, MH, Eskandarieh, S, Farzadfar, F, Fernandes, AG, Fischer, F, Friedman, DS, Furtado, JM, Gaidhane, S, Gazzard, G, Gebremichael, B, George, R, Ghashghaee, A, Gilani, SA, Golechha, M, Hamidi, S, Hammond, BR, Hartnett, MER, Hartono, RK, Hashi, A, Hay, S, Hayat, K, Heidari, G, Ho, HC, Holla, R, Househ, M, Huang, JJ, Ibitoye, SE, Ilic, IM, Ilic, MD, Ingram, AD, Irvani, SSN, Islam, SMS, Itumalla, R, Jayaram, S, Jha, RP, Kahloun, R, Kalhor, R, Kandel, H, Kasa, AS, Kavetskyy, T, Kayode, GA, Kempen, JH, Khairallah, M, Khalilov, R, Khan, EA, Khanna, RC, Khatib, MN, Khoja, TAM, Kim, GR, Kim, JE, Kim, YJ, Kisa, A, Kisa, S, Kosen, S, Koyanagi, A, Bicer, BK, Kulkarni, V, Kurmi, OP, Landires, I, Lansingh, VC, Leasher, JL, LeGrand, KE, Leveziel, N, Limburg, H, Liu, X, Kunjathur, SM, Maleki, S, Manafi, N, Mansouri, K, McAlinden, C, Meles, GG, Mersha, AM, Michalek, IM, Miller, TR, Misra, S, Mohammad, Y, Mohammadi, SF, Mohammed, JA, Mokdad, AH, Moni, MA, Al Montasir, A, Morse, AR, Mulaw, GF, Naderi, M, Naderifar, H, Naidoo, KS, Naimzada, MD, Nangia, V, Swamy, SN, Naveed, M, Negash, H, Huong, LTN, Nunez-Samudio, V, Ogbo, FA, Ogundimu, K, Olagunju, AT, Onwujekwe, OE, Otstavnov, N, Owolabi, MO, Pakshir, K, Panda-Jonas, S, Parekh, U, Park, E-C, Pasovic, M, Pawar, S, Pesudovs, K, Peto, T, Pham, HQ, Pinheiro, M, Podder, V, Rahimi-Movaghar, V, Rahman, MHU, Ramulu, PY, Rathi, P, Rawaf, DL, Rawaf, S, Rawal, L, Reinig, N, Renzaho, AMN, Rezapour, A, Robin, AL, Rossetti, L, Sabour, S, Safi, S, Sahebkar, A, Sahraian, MA, Samy, AM, Sathian, B, Saya, GK, Saylan, M, Shaheen, AA, Shaikh, MA, Shen, TT, Shibuya, K, Shiferaw, WS, Shigematsu, M, Shin, JI, Silva, JC, Silvester, A, Singh, JA, Singhal, D, Sitorus, RS, Skiadaresi, E, Skryabin, VY, Skryabina, AA, Soheili, A, Sorrie, MB, Sousa, RARC, Sreeramareddy, CT, Stambolian, D, Tadesse, EG, Tahhan, N, Tareque, MI, Topouzis, F, Bach, XT, Tsegaye, GW, Tsilimbaris, MK, Varma, R, Virgili, G, Vongpradith, A, Vu, GT, Wang, YX, Wang, N, Weldemariam, AH, West, SK, Wondmeneh, TG, Wong, TY, Yaseri, M, Yonemoto, N, Yu, C, Zastrozhin, MS, Zastrozhina, A, Zhang, Z-J, Zimsen, SRM, Resnikoff, S, and Vos, T
Abstract: BACKGROUND: Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. We aimed to compare the results with the World Health Assembly Global Action Plan (WHA GAP) target of a 25% global reduction from 2010 to 2019 in avoidable vision impairment, defined as cataract and undercorrected refractive error. METHODS: We did a systematic review and meta-analysis of population-based surveys of eye disease from January, 1980, to October, 2018. We fitted hierarchical models to estimate prevalence (with 95% uncertainty intervals [UIs]) of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness (<3/60 or less than 10° visual field around central fixation) by cause, age, region, and year. Because of data sparsity at younger ages, our analysis focused on adults aged 50 years and older. FINDINGS: Global crude prevalence of avoidable vision impairment and blindness in adults aged 50 years and older did not change between 2010 and 2019 (percentage change -0·2% [95% UI -1·5 to 1·0]; 2019 prevalence 9·58 cases per 1000 people [95% IU 8·51 to 10·8], 2010 prevalence 96·0 cases per 1000 people [86·0 to 107·0]). Age-standardised prevalence of avoidable blindness decreased by -15·4% [-16·8 to -14·3], while avoidable MSVI showed no change (0·5% [-0·8 to 1·6]). However, the number of cases increased for both avoidable blindness (10·8% [8·9 to 12·4]) and MSVI (31·5% [30·0 to 33·1]). The leading global causes of blindness in those aged 50 years and older in 2020 were cataract (15·2 million cases [9% IU 12·7-18·0]), followed by glaucoma (3·6 million cases [2·8-4·4]), undercorrected refractive error (2·3 million cases [1·8-2·8]), age-related macular degeneration (1·8 million cases [1·3-2·4]), and diabetic retinopathy (0·86 mill
Published: 2021

14. Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems

Author: Cork, MA, Henry, NJ, Watson, S, Croneberger, AJ, Baumann, M, Letourneau, ID, Yang, M, Serfes, AL, Abbas, J, Abbasi, N, Abbastabar, H, Abreu, LG, Abu-Gharbieh, E, Achappa, B, Adabi, M, Adal, TG, Adegbosin, AE, Adekanmbi, V, Adetokunboh, OO, Agudelo-Botero, M, Ahinkorah, BO, Ahmadi, K, Ahmed, MB, Alhassan, RK, Alipour, V, Almasi-Hashiani, A, Alvis-Guzman, N, Ancuceanu, R, Andrei, T, Anvari, D, Aqeel, M, Arabloo, J, Aremu, O, Asaad, M, Atnafu, DD, Atreya, A, Quintanilla, BPA, Azari, S, Darshan, BB, Baig, AA, Banach, M, Bante, SA, Barboza, MA, Basu, S, Bedi, N, Bejarano Ramirez, DF, Bensenor, IM, Beyene, FY, Bezabih, YM, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhutta, ZA, Bijani, A, Birlik, SM, Bitew, ZW, Bohlouli, S, Boloor, A, Brunoni, AR, Butt, ZA, Cardenas, R, Carvalho, F, Castaldelli-Maia, JM, Castaneda-Orjuela, CA, Charan, J, Chatterjee, S, Chattu, VK, Chattu, SK, Chowdhury, MAK, Christopher, DJ, Chu, D-T, Cook, AJ, Cormier, NM, Dahlawi, SMA, Daoud, F, Davila Cervantes, CA, Weaver, ND, De la Hoz, FP, Demeke, FM, Denova-Gutierrez, E, Deribe, K, Deuba, K, Dharmaratne, SD, Dhungana, GP, Diaz, D, Djalalinia, S, Duraes, AR, Eagan, AW, Earl, L, Effiong, A, Zaki, MES, El Tantawi, M, Elayedath, R, El-Jaafary, SI, Faraon, EJA, Faro, A, Fattahi, N, Fauk, NK, Fernandes, E, Filip, I, Fischer, F, Foigt, NA, Foroutan, M, Fukumoto, T, Gad, MM, Gebremariam, TBB, Gebremedhin, KB, Gebremeskel, GG, Gesesew, HA, Ghadiri, K, Ghashghaee, A, Gilani, SA, Golechha, M, Gori, U, Goulart, AC, Goulart, BNG, Gugnani, HC, Guimaraes, MDC, Guimaraes, RA, Guo, Y, Gupta, R, Haeuser, E, Haider, MR, Haile, TG, Haj-Mirzaian, A, Hanif, A, Hargono, A, Hariyani, N, Hassanipour, S, Hassankhani, H, Hayat, K, Herteliu, C, Ho, HC, Holla, R, Hosseinzadeh, M, Househ, M, Hwang, BF, Ibeneme, CU, Ibitoye, SE, Ilesanmi, OS, Ilic, MD, Ilic, IM, Iqbal, U, Jahagirdar, D, Jain, V, Jakovljevic, M, Jha, RP, Johnson, KB, Joseph, N, Joukar, F, Kalankesh, LR, Kalhor, R, Kanchan, T, Matin, BK, Karch, A, Karimi, SE, Kassahun, G, Kayode, GA, Karyani, AK, Keramati, M, Khalid, N, Khan, EA, Khan, G, Khan, MNN, Khatab, K, Kianipour, N, Kim, YJ, Kisa, S, Kisa, A, Kosen, S, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Defo, BK, Kuchenbecker, RS, Kulkarni, V, Kumar, N, Kumar, M, Kurmi, OP, Kusuma, D, La Vecchia, C, Lal, DK, Landires, I, Lasrado, S, Lee, PH, LeGrand, KE, Li, B, Li, S, Liu, X, Amin, HIM, Machado, DB, Madi, D, Magis-Rodriguez, C, Malta, DC, Mansournia, MA, Manzar, MD, Marrugo Arnedo, CA, Martins-Melo, FR, Masoumi, SZ, Mayala, BK, Medina-Solis, CE, Memish, ZA, Mendoza, W, Menezes, RG, Mestrovic, T, Mirica, A, Moazen, B, Mohammad, Y, Mezerji, NMG, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, S, Mokdad, AH, Moni, MA, Moradi, M, Moradi, Y, Moradzadeh, R, Moraga, P, Khaneghah, AM, Mustafa, G, Mwanri, L, Nagaraja, R, Nagarajan, AJ, Naimzada, MD, Nascimento, BR, Naveed, M, Nayak, VC, Nazari, J, Negash, H, Negoi, I, Nepal, S, Nguefack-Tsague, G, Nguyen, CT, Nguyen, HLT, Nikbakhsh, R, Noubiap, JJ, Nunez-Samudio, V, Oancea, B, Ogbo, FA, Olagunju, AT, Otstavnov, N, Mahesh, PA, Padubidri, JR, Perumal, SRP, Pardo-Montano, AM, Patel, UK, Pawar, S, Peprah, EK, Pereira, A, Perkins, S, Pescarini, JM, Pokhrel, KN, Postma, MJ, Pottoo, FH, Prada, SI, Preotescu, L, Pribadi, DRA, Radfar, A, Rahim, F, Rahman, MHU, Rahmani, AM, Ramezanzadeh, K, Rana, J, Ranabhat, CL, Rao, SJ, Rathi, P, Rawaf, S, Rawaf, DL, Rawassizadeh, R, Renjith, V, Rezaei, N, Rezapour, A, Ribeiro, AI, Roever, L, Rubagotti, E, Rumisha, SF, Rwegerera, GM, Sagar, R, Sajadi, SM, Salem, MR, Samy, AM, Sarmiento-Suarez, R, Sathian, B, Schaeffer, LE, Schneider, IJC, Seidu, A-A, Sha, F, Shaikh, MA, Sharafi, K, Sheikh, A, Shibuya, K, Shin, JI, Silva, DAS, Singh, JA, Skryabin, VY, Skryabina, AA, Sligar, A, Soheili, A, Steuben, KM, Sufiyan, MB, Tadesse, EG, Tesema, AKT, Tesfay, FH, Thapar, R, Thompson, RL, Tovani-Palone, MR, Tran, BX, Tsegaye, GW, Umeokonkwo, CD, Unnikrishnan, B, Vasseghian, Y, Violante, FS, Vo, B, Vu, GT, Waheed, Y, Wang, Y-P, Wang, Y, Ward, P, Welay, FT, Westerman, R, Wickramasinghe, ND, Yaya, S, Yip, P, Yonemoto, N, Yu, C, Yuce, D, Yusefzadeh, H, Zamanian, M, Zastrozhin, MS, Zhang, Z-J, Zhang, Y, Ziapour, A, Hay, SI, Dwyer-Lindgren, L, Cork, MA, Henry, NJ, Watson, S, Croneberger, AJ, Baumann, M, Letourneau, ID, Yang, M, Serfes, AL, Abbas, J, Abbasi, N, Abbastabar, H, Abreu, LG, Abu-Gharbieh, E, Achappa, B, Adabi, M, Adal, TG, Adegbosin, AE, Adekanmbi, V, Adetokunboh, OO, Agudelo-Botero, M, Ahinkorah, BO, Ahmadi, K, Ahmed, MB, Alhassan, RK, Alipour, V, Almasi-Hashiani, A, Alvis-Guzman, N, Ancuceanu, R, Andrei, T, Anvari, D, Aqeel, M, Arabloo, J, Aremu, O, Asaad, M, Atnafu, DD, Atreya, A, Quintanilla, BPA, Azari, S, Darshan, BB, Baig, AA, Banach, M, Bante, SA, Barboza, MA, Basu, S, Bedi, N, Bejarano Ramirez, DF, Bensenor, IM, Beyene, FY, Bezabih, YM, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhutta, ZA, Bijani, A, Birlik, SM, Bitew, ZW, Bohlouli, S, Boloor, A, Brunoni, AR, Butt, ZA, Cardenas, R, Carvalho, F, Castaldelli-Maia, JM, Castaneda-Orjuela, CA, Charan, J, Chatterjee, S, Chattu, VK, Chattu, SK, Chowdhury, MAK, Christopher, DJ, Chu, D-T, Cook, AJ, Cormier, NM, Dahlawi, SMA, Daoud, F, Davila Cervantes, CA, Weaver, ND, De la Hoz, FP, Demeke, FM, Denova-Gutierrez, E, Deribe, K, Deuba, K, Dharmaratne, SD, Dhungana, GP, Diaz, D, Djalalinia, S, Duraes, AR, Eagan, AW, Earl, L, Effiong, A, Zaki, MES, El Tantawi, M, Elayedath, R, El-Jaafary, SI, Faraon, EJA, Faro, A, Fattahi, N, Fauk, NK, Fernandes, E, Filip, I, Fischer, F, Foigt, NA, Foroutan, M, Fukumoto, T, Gad, MM, Gebremariam, TBB, Gebremedhin, KB, Gebremeskel, GG, Gesesew, HA, Ghadiri, K, Ghashghaee, A, Gilani, SA, Golechha, M, Gori, U, Goulart, AC, Goulart, BNG, Gugnani, HC, Guimaraes, MDC, Guimaraes, RA, Guo, Y, Gupta, R, Haeuser, E, Haider, MR, Haile, TG, Haj-Mirzaian, A, Hanif, A, Hargono, A, Hariyani, N, Hassanipour, S, Hassankhani, H, Hayat, K, Herteliu, C, Ho, HC, Holla, R, Hosseinzadeh, M, Househ, M, Hwang, BF, Ibeneme, CU, Ibitoye, SE, Ilesanmi, OS, Ilic, MD, Ilic, IM, Iqbal, U, Jahagirdar, D, Jain, V, Jakovljevic, M, Jha, RP, Johnson, KB, Joseph, N, Joukar, F, Kalankesh, LR, Kalhor, R, Kanchan, T, Matin, BK, Karch, A, Karimi, SE, Kassahun, G, Kayode, GA, Karyani, AK, Keramati, M, Khalid, N, Khan, EA, Khan, G, Khan, MNN, Khatab, K, Kianipour, N, Kim, YJ, Kisa, S, Kisa, A, Kosen, S, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Defo, BK, Kuchenbecker, RS, Kulkarni, V, Kumar, N, Kumar, M, Kurmi, OP, Kusuma, D, La Vecchia, C, Lal, DK, Landires, I, Lasrado, S, Lee, PH, LeGrand, KE, Li, B, Li, S, Liu, X, Amin, HIM, Machado, DB, Madi, D, Magis-Rodriguez, C, Malta, DC, Mansournia, MA, Manzar, MD, Marrugo Arnedo, CA, Martins-Melo, FR, Masoumi, SZ, Mayala, BK, Medina-Solis, CE, Memish, ZA, Mendoza, W, Menezes, RG, Mestrovic, T, Mirica, A, Moazen, B, Mohammad, Y, Mezerji, NMG, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, S, Mokdad, AH, Moni, MA, Moradi, M, Moradi, Y, Moradzadeh, R, Moraga, P, Khaneghah, AM, Mustafa, G, Mwanri, L, Nagaraja, R, Nagarajan, AJ, Naimzada, MD, Nascimento, BR, Naveed, M, Nayak, VC, Nazari, J, Negash, H, Negoi, I, Nepal, S, Nguefack-Tsague, G, Nguyen, CT, Nguyen, HLT, Nikbakhsh, R, Noubiap, JJ, Nunez-Samudio, V, Oancea, B, Ogbo, FA, Olagunju, AT, Otstavnov, N, Mahesh, PA, Padubidri, JR, Perumal, SRP, Pardo-Montano, AM, Patel, UK, Pawar, S, Peprah, EK, Pereira, A, Perkins, S, Pescarini, JM, Pokhrel, KN, Postma, MJ, Pottoo, FH, Prada, SI, Preotescu, L, Pribadi, DRA, Radfar, A, Rahim, F, Rahman, MHU, Rahmani, AM, Ramezanzadeh, K, Rana, J, Ranabhat, CL, Rao, SJ, Rathi, P, Rawaf, S, Rawaf, DL, Rawassizadeh, R, Renjith, V, Rezaei, N, Rezapour, A, Ribeiro, AI, Roever, L, Rubagotti, E, Rumisha, SF, Rwegerera, GM, Sagar, R, Sajadi, SM, Salem, MR, Samy, AM, Sarmiento-Suarez, R, Sathian, B, Schaeffer, LE, Schneider, IJC, Seidu, A-A, Sha, F, Shaikh, MA, Sharafi, K, Sheikh, A, Shibuya, K, Shin, JI, Silva, DAS, Singh, JA, Skryabin, VY, Skryabina, AA, Sligar, A, Soheili, A, Steuben, KM, Sufiyan, MB, Tadesse, EG, Tesema, AKT, Tesfay, FH, Thapar, R, Thompson, RL, Tovani-Palone, MR, Tran, BX, Tsegaye, GW, Umeokonkwo, CD, Unnikrishnan, B, Vasseghian, Y, Violante, FS, Vo, B, Vu, GT, Waheed, Y, Wang, Y-P, Wang, Y, Ward, P, Welay, FT, Westerman, R, Wickramasinghe, ND, Yaya, S, Yip, P, Yonemoto, N, Yu, C, Yuce, D, Yusefzadeh, H, Zamanian, M, Zastrozhin, MS, Zhang, Z-J, Zhang, Y, Ziapour, A, Hay, SI, and Dwyer-Lindgren, L
Abstract: BACKGROUND: Human immunodeficiency virus (HIV) remains a public health priority in Latin America. While the burden of HIV is historically concentrated in urban areas and high-risk groups, subnational estimates that cover multiple countries and years are missing. This paucity is partially due to incomplete vital registration (VR) systems and statistical challenges related to estimating mortality rates in areas with low numbers of HIV deaths. In this analysis, we address this gap and provide novel estimates of the HIV mortality rate and the number of HIV deaths by age group, sex, and municipality in Brazil, Colombia, Costa Rica, Ecuador, Guatemala, and Mexico. METHODS: We performed an ecological study using VR data ranging from 2000 to 2017, dependent on individual country data availability. We modeled HIV mortality using a Bayesian spatially explicit mixed-effects regression model that incorporates prior information on VR completeness. We calibrated our results to the Global Burden of Disease Study 2017. RESULTS: All countries displayed over a 40-fold difference in HIV mortality between municipalities with the highest and lowest age-standardized HIV mortality rate in the last year of study for men, and over a 20-fold difference for women. Despite decreases in national HIV mortality in all countries-apart from Ecuador-across the period of study, we found broad variation in relative changes in HIV mortality at the municipality level and increasing relative inequality over time in all countries. In all six countries included in this analysis, 50% or more HIV deaths were concentrated in fewer than 10% of municipalities in the latest year of study. In addition, national age patterns reflected shifts in mortality to older age groups-the median age group among decedents ranged from 30 to 45 years of age at the municipality level in Brazil, Colombia, and Mexico in 2017. CONCLUSIONS: Our subnational estimates of HIV mortality revealed significant spatial variation and divergi
Published: 2021

15. Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050

Author: Micah, AE, Cogswell, IE, Cunningham, B, Ezoe, S, Harle, AC, Maddison, ER, McCracken, D, Nomura, S, Simpson, KE, Stutzman, HN, Tsakalos, G, Wallace, LE, Zhao, Y, Zende, RR, Abbafati, C, Abdelmasseh, M, Abedi, A, Abegaz, KH, Abhilash, ES, Abolhassani, H, Abrigo, MRM, Adhikari, TB, Afzal, S, Ahinkorah, BO, Ahmadi, S, Ahmed, H, Ahmed, MB, Rashid, TA, Ajami, M, Aji, B, Akalu, Y, Akunna, CJ, Al Hamad, H, Alam, K, Alanezi, FM, Alanzi, TM, Alemayehu, Y, Alhassan, RK, Alinia, C, Aljunid, SM, Almustanyir, SA, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Amini, S, Amini-Rarani, M, Amu, H, Ancuceanu, R, Andrei, CL, Andrei, T, Angell, B, Anjomshoa, M, Antonio, CAT, Antony, CM, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aripov, T, Arrigo, A, Ashraf, T, Atnafu, DD, Ausloos, M, Avila-Burgos, L, Awan, AT, Ayano, G, Ayanore, MA, Azari, S, Azhar, GS, Babalola, TK, Bahrami, MA, Baig, AA, Banach, M, Barati, N, Barnighausen, TW, Barrow, A, Basu, S, Baune, BT, Bayati, M, Benzian, H, Berman, AE, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bibi, S, Bijani, A, Bodolica, V, Bragazzi, NL, Braithwaite, D, Breitborde, NJK, Breusov, AV, Briko, NI, Busse, R, Cahuana-Hurtado, L, Callander, EJ, Camera, LA, Castaneda-Orjuela, CA, Catala-Lopez, F, Charan, J, Chatterjee, S, Chattu, SK, Chattu, VK, Chen, S, Cicero, AFG, Dadras, O, Dahlawi, SMA, Dai, X, Dalal, K, Dandona, L, Dandona, R, Davitoiu, DV, De Neve, J-W, de Sa-Junior, AR, Denova-Gutierrez, E, Dhamnetiya, D, Dharmaratne, SD, Doshmangir, L, Dube, J, Ehsani-Chimeh, E, Zaki, MES, El Tantawi, M, Eskandarieh, S, Farzadfar, F, Ferede, TY, Fischer, F, Foigt, NA, Freitas, A, Friedman, SD, Fukumoto, T, Fullman, N, Gaal, PA, Gad, MM, Garcia-Gordillo, MA, Garg, T, Ghafourifard, M, Ghashghaee, A, Gholamian, A, Gholamrezanezhad, A, Ghozali, G, Gilani, SA, Glavan, I-R, Glushkova, EV, Goharinezhad, S, Golechha, M, Goli, S, Guha, A, Gupta, VB, Gupta, VK, Haakenstad, A, Haider, MR, Hailu, A, Hamidi, S, Hanif, A, Harapan, H, Hartono, RK, Hasaballah, AI, Hassan, S, Hassanein, MH, Hayat, K, Hegazy, MI, Heidari, G, Hendrie, D, Heredia-Pi, I, Herteliu, C, Hezam, K, Holla, R, Hossain, SJ, Hosseinzadeh, M, Hostiuc, S, Huda, TM, Hwang, B-F, Iavicoli, I, Idrisov, B, Ilesanmi, OS, Irvani, SSN, Islam, SMS, Ismail, NE, Isola, G, Jahani, MA, Jahanmehr, N, Jakovljevic, M, Janodia, MD, Javaheri, T, Jayapal, SK, Jayawardena, R, Jazayeri, SB, Jha, RP, Jonas, JB, Joo, T, Joukar, F, Jurisson, M, Kaambwa, B, Kalhor, R, Kanchan, T, Kandel, H, Matin, BK, Karimi, SE, Kassahun, G, Kayode, GA, Karyani, AK, Keikavoosi-Arani, L, Khader, YS, Khajuria, H, Khalilov, R, Khammarnia, M, Khan, J, Khubchandani, J, Kianipour, N, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kohler, S, Kosen, S, Koteeswaran, R, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Kumar, GA, Kusuma, D, Lamnisos, D, Lansingh, VC, Larsson, AO, Lasrado, S, Le, LKD, Lee, SWH, Lee, YY, Lim, SS, Lobo, SW, Lozano, R, Abd El Razek, HM, Abd El Razek, MM, Mahdavi, MM, Majeed, A, Makki, A, Maleki, A, Malekzadeh, R, Manda, AL, Mansour-Ghanaei, F, Mansournia, MA, Arnedo, CAM, Martinez-Valle, A, Masoumi, SZ, Maude, RJ, Mckee, M, Medina-Solis, CE, Menezes, RG, Meretoja, A, Meretoja, TJ, Mesregah, MK, Mestrovic, T, Kostova, NM, Miller, TR, Mini, GK, Mirica, A, Mirrakhimov, EM, Mohajer, B, Mohamed, TA, Mohammadi, M, Mohammadian-Hafshejani, A, Mohammed, S, Moitra, M, Mokdad, AH, Molokhia, M, Moni, MA, Moradi, Y, Morze, J, Mousavi, SM, Mpundu-Kaambwa, C, Muriithi, MK, Muthupandian, S, Nagarajan, AJ, Naimzada, MD, Nangia, V, Naqvi, AA, Narayana, AI, Nascimento, BR, Naveed, M, Nayak, BP, Nazari, J, Ndejjo, R, Negoi, I, Kandel, SN, Trang, HN, Nonvignon, J, Noubiap, JJ, Nwatah, VE, Oancea, B, Ojelabi, FAO, Olagunju, AT, Olakunde, BO, Olgiati, S, Olusanya, JO, Onwujekwe, OE, Otoiu, A, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Padubidri, JR, Palladino, R, Panda-Jonas, S, Park, E-C, Kan, FP, Pawar, S, Toroudi, HP, Pereira, DM, Perianayagam, A, Pesudovs, K, Piccinelli, C, Postma, MJ, Prada, SI, Rabiee, M, Rabiee, N, Rahim, F, Rahimi-Movaghar, V, Rahman, MHU, Rahman, M, Rahmani, AM, Ram, U, Ranabhat, CL, Ranasinghe, P, Rao, CR, Rathi, P, Rawaf, DL, Rawaf, S, Rawal, L, Rawassizadeh, R, Reiner, RC, Renzaho, AMN, Reshmi, B, Riaz, MA, Ripon, RK, Saad, AM, Sahraian, MA, Sahu, M, Salama, JS, Salehi, S, Samy, AM, Sanabria, J, Sanmarchi, F, Santos, JV, Santric-Milicevic, MM, Sathian, B, Savic, M, Saxena, D, Sayyah, M, Schwendicke, F, Senthilkumaran, S, Sepanlou, SG, Seylani, A, Shahabi, S, Shaikh, MA, Sheikh, A, Shetty, A, Shetty, PH, Shibuya, K, Shrime, MG, Shuja, KH, Singh, JA, Skryabin, VY, Skryabina, AA, Soltani, S, Soofi, M, Spurlock, EE, Stefan, SC, Szerencses, V, Szocska, M, Tabares-Seisdedos, R, Taddele, BW, Tefera, YG, Thavamani, A, Tobe-Gai, R, Topor-Madry, R, Tovani-Palone, MR, Bach, XT, Car, LT, Ullah, A, Ullah, S, Umar, N, Undurraga, EA, Valdez, PR, Vasankari, TJ, Villafane, JH, Violante, FS, Vlassov, V, Bay, V, Vollmer, S, Theo, V, Giang, TV, Linh, GV, Wamai, RG, Werdecker, A, Woldekidan, MA, Wubishet, BL, Xu, G, Yaya, S, Yazdi-Feyzabadi, V, Yigit, V, Yip, P, Yirdaw, BW, Yonemoto, N, Younis, MZ, Yu, C, Yunusa, I, Moghadam, TZ, Zandian, H, Zastrozhin, MS, Zastrozhina, A, Zhang, Z-J, Ziapour, A, Zuniga, YMH, Hay, SI, Murray, CJL, Dieleman, JL, Micah, AE, Cogswell, IE, Cunningham, B, Ezoe, S, Harle, AC, Maddison, ER, McCracken, D, Nomura, S, Simpson, KE, Stutzman, HN, Tsakalos, G, Wallace, LE, Zhao, Y, Zende, RR, Abbafati, C, Abdelmasseh, M, Abedi, A, Abegaz, KH, Abhilash, ES, Abolhassani, H, Abrigo, MRM, Adhikari, TB, Afzal, S, Ahinkorah, BO, Ahmadi, S, Ahmed, H, Ahmed, MB, Rashid, TA, Ajami, M, Aji, B, Akalu, Y, Akunna, CJ, Al Hamad, H, Alam, K, Alanezi, FM, Alanzi, TM, Alemayehu, Y, Alhassan, RK, Alinia, C, Aljunid, SM, Almustanyir, SA, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Amini, S, Amini-Rarani, M, Amu, H, Ancuceanu, R, Andrei, CL, Andrei, T, Angell, B, Anjomshoa, M, Antonio, CAT, Antony, CM, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aripov, T, Arrigo, A, Ashraf, T, Atnafu, DD, Ausloos, M, Avila-Burgos, L, Awan, AT, Ayano, G, Ayanore, MA, Azari, S, Azhar, GS, Babalola, TK, Bahrami, MA, Baig, AA, Banach, M, Barati, N, Barnighausen, TW, Barrow, A, Basu, S, Baune, BT, Bayati, M, Benzian, H, Berman, AE, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bibi, S, Bijani, A, Bodolica, V, Bragazzi, NL, Braithwaite, D, Breitborde, NJK, Breusov, AV, Briko, NI, Busse, R, Cahuana-Hurtado, L, Callander, EJ, Camera, LA, Castaneda-Orjuela, CA, Catala-Lopez, F, Charan, J, Chatterjee, S, Chattu, SK, Chattu, VK, Chen, S, Cicero, AFG, Dadras, O, Dahlawi, SMA, Dai, X, Dalal, K, Dandona, L, Dandona, R, Davitoiu, DV, De Neve, J-W, de Sa-Junior, AR, Denova-Gutierrez, E, Dhamnetiya, D, Dharmaratne, SD, Doshmangir, L, Dube, J, Ehsani-Chimeh, E, Zaki, MES, El Tantawi, M, Eskandarieh, S, Farzadfar, F, Ferede, TY, Fischer, F, Foigt, NA, Freitas, A, Friedman, SD, Fukumoto, T, Fullman, N, Gaal, PA, Gad, MM, Garcia-Gordillo, MA, Garg, T, Ghafourifard, M, Ghashghaee, A, Gholamian, A, Gholamrezanezhad, A, Ghozali, G, Gilani, SA, Glavan, I-R, Glushkova, EV, Goharinezhad, S, Golechha, M, Goli, S, Guha, A, Gupta, VB, Gupta, VK, Haakenstad, A, Haider, MR, Hailu, A, Hamidi, S, Hanif, A, Harapan, H, Hartono, RK, Hasaballah, AI, Hassan, S, Hassanein, MH, Hayat, K, Hegazy, MI, Heidari, G, Hendrie, D, Heredia-Pi, I, Herteliu, C, Hezam, K, Holla, R, Hossain, SJ, Hosseinzadeh, M, Hostiuc, S, Huda, TM, Hwang, B-F, Iavicoli, I, Idrisov, B, Ilesanmi, OS, Irvani, SSN, Islam, SMS, Ismail, NE, Isola, G, Jahani, MA, Jahanmehr, N, Jakovljevic, M, Janodia, MD, Javaheri, T, Jayapal, SK, Jayawardena, R, Jazayeri, SB, Jha, RP, Jonas, JB, Joo, T, Joukar, F, Jurisson, M, Kaambwa, B, Kalhor, R, Kanchan, T, Kandel, H, Matin, BK, Karimi, SE, Kassahun, G, Kayode, GA, Karyani, AK, Keikavoosi-Arani, L, Khader, YS, Khajuria, H, Khalilov, R, Khammarnia, M, Khan, J, Khubchandani, J, Kianipour, N, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kohler, S, Kosen, S, Koteeswaran, R, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Kumar, GA, Kusuma, D, Lamnisos, D, Lansingh, VC, Larsson, AO, Lasrado, S, Le, LKD, Lee, SWH, Lee, YY, Lim, SS, Lobo, SW, Lozano, R, Abd El Razek, HM, Abd El Razek, MM, Mahdavi, MM, Majeed, A, Makki, A, Maleki, A, Malekzadeh, R, Manda, AL, Mansour-Ghanaei, F, Mansournia, MA, Arnedo, CAM, Martinez-Valle, A, Masoumi, SZ, Maude, RJ, Mckee, M, Medina-Solis, CE, Menezes, RG, Meretoja, A, Meretoja, TJ, Mesregah, MK, Mestrovic, T, Kostova, NM, Miller, TR, Mini, GK, Mirica, A, Mirrakhimov, EM, Mohajer, B, Mohamed, TA, Mohammadi, M, Mohammadian-Hafshejani, A, Mohammed, S, Moitra, M, Mokdad, AH, Molokhia, M, Moni, MA, Moradi, Y, Morze, J, Mousavi, SM, Mpundu-Kaambwa, C, Muriithi, MK, Muthupandian, S, Nagarajan, AJ, Naimzada, MD, Nangia, V, Naqvi, AA, Narayana, AI, Nascimento, BR, Naveed, M, Nayak, BP, Nazari, J, Ndejjo, R, Negoi, I, Kandel, SN, Trang, HN, Nonvignon, J, Noubiap, JJ, Nwatah, VE, Oancea, B, Ojelabi, FAO, Olagunju, AT, Olakunde, BO, Olgiati, S, Olusanya, JO, Onwujekwe, OE, Otoiu, A, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Padubidri, JR, Palladino, R, Panda-Jonas, S, Park, E-C, Kan, FP, Pawar, S, Toroudi, HP, Pereira, DM, Perianayagam, A, Pesudovs, K, Piccinelli, C, Postma, MJ, Prada, SI, Rabiee, M, Rabiee, N, Rahim, F, Rahimi-Movaghar, V, Rahman, MHU, Rahman, M, Rahmani, AM, Ram, U, Ranabhat, CL, Ranasinghe, P, Rao, CR, Rathi, P, Rawaf, DL, Rawaf, S, Rawal, L, Rawassizadeh, R, Reiner, RC, Renzaho, AMN, Reshmi, B, Riaz, MA, Ripon, RK, Saad, AM, Sahraian, MA, Sahu, M, Salama, JS, Salehi, S, Samy, AM, Sanabria, J, Sanmarchi, F, Santos, JV, Santric-Milicevic, MM, Sathian, B, Savic, M, Saxena, D, Sayyah, M, Schwendicke, F, Senthilkumaran, S, Sepanlou, SG, Seylani, A, Shahabi, S, Shaikh, MA, Sheikh, A, Shetty, A, Shetty, PH, Shibuya, K, Shrime, MG, Shuja, KH, Singh, JA, Skryabin, VY, Skryabina, AA, Soltani, S, Soofi, M, Spurlock, EE, Stefan, SC, Szerencses, V, Szocska, M, Tabares-Seisdedos, R, Taddele, BW, Tefera, YG, Thavamani, A, Tobe-Gai, R, Topor-Madry, R, Tovani-Palone, MR, Bach, XT, Car, LT, Ullah, A, Ullah, S, Umar, N, Undurraga, EA, Valdez, PR, Vasankari, TJ, Villafane, JH, Violante, FS, Vlassov, V, Bay, V, Vollmer, S, Theo, V, Giang, TV, Linh, GV, Wamai, RG, Werdecker, A, Woldekidan, MA, Wubishet, BL, Xu, G, Yaya, S, Yazdi-Feyzabadi, V, Yigit, V, Yip, P, Yirdaw, BW, Yonemoto, N, Younis, MZ, Yu, C, Yunusa, I, Moghadam, TZ, Zandian, H, Zastrozhin, MS, Zastrozhina, A, Zhang, Z-J, Ziapour, A, Zuniga, YMH, Hay, SI, Murray, CJL, and Dieleman, JL
Abstract: BACKGROUND: The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. METHODS: We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$ per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. FINDINGS: In 2019, health spending globally reached $8·8 trillion (95% uncertainty interval [UI] 8·7-8·8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this t
Published: 2021

16. Measuring routine childhood vaccination coverage in 204 countries and territories, 1980-2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1

Author: Galles, NC, Liu, PY, Updike, RL, Fullman, N, Nguyen, J, Rolfe, S, Sbarra, AN, Schipp, MF, Marks, A, Abady, GG, Abbas, KM, Abbasi, SW, Abbastabar, H, Abd-Allah, F, Abdoli, A, Abolhassani, H, Abosetugn, AE, Adabi, M, Adamu, AA, Adetokunboh, OO, Adnani, QES, Advani, SM, Afzal, S, Aghamir, SMK, Ahinkorah, BO, Ahmad, S, Ahmad, T, Ahmadi, S, Ahmed, H, Ahmed, MB, Rashid, TA, Salih, YA, Akalu, Y, Aklilu, A, Akunna, CJ, Al Hamad, H, Alahdab, F, Albano, L, Alemayehu, Y, Alene, KA, Al-Eyadhy, A, Alhassan, RK, Ali, L, Aljunid, SM, Almustanyir, S, Altirkawi, KA, Alvis-Guzman, N, Amu, H, Andrei, CL, Andrei, T, Ansar, A, Ansari-Moghaddam, A, Antonazzo, IC, Antony, B, Arabloo, J, Arab-Zozani, M, Artanti, KD, Arulappan, J, Awan, AT, Awoke, MA, Ayza, MA, Azarian, G, Azzam, AY, Darshan, BB, Babar, Z-U-D, Balakrishnan, S, Banach, M, Bante, SA, Barnighausen, TW, Barqawi, HJ, Barrow, A, Bassat, Q, Bayarmagnai, N, Ramirez, DFB, Bekuma, TT, Belay, HG, Belgaumi, UI, Bhagavathula, AS, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Bibi, S, Bijani, A, Biondi, A, Boloor, A, Braithwaite, D, Buonsenso, D, Butt, ZA, Camargos, P, Carreras, G, Carvalho, F, Castaneda-Orjuela, CA, Chakinala, RC, Charan, J, Chatterjee, S, Chattu, SK, Chattu, VK, Chowdhury, FR, Christopher, DJ, Chu, D-T, Chung, S-C, Cortesi, PA, Costa, VM, Couto, RAS, Dadras, O, Dagnew, AB, Dagnew, B, Dai, X, Dandona, L, Dandona, R, De Neve, J-W, Molla, MD, Derseh, BT, Desai, R, Desta, AA, Dhamnetiya, D, Dhimal, ML, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Dorostkar, F, Edem, B, Edinur, HA, Eftekharzadeh, S, El Sayed, I, Zaki, MES, Elhadi, M, El-Jaafary, S, Elsharkawy, A, Enany, S, Erkhembayar, R, Esezobor, CI, Eskandarieh, S, Ezeonwumelu, IJ, Ezzikouri, S, Fares, J, Faris, PS, Feleke, BE, Ferede, TY, Fernandes, E, Fernandes, JC, Ferrara, P, Filip, I, Fischer, F, Francis, MR, Fukumoto, T, Gad, MM, Gaidhane, S, Gallus, S, Garg, T, Geberemariyam, BS, Gebre, T, Gebregiorgis, BG, Gebremedhin, KB, Gebremichael, B, Gessner, BD, Ghadiri, K, Ghafourifard, M, Ghashghaee, A, Gilani, SA, Glavan, I-R, Glushkova, EV, Golechha, M, Gonfa, KB, Gopalani, SV, Goudarzi, H, Gubari, MIM, Guo, Y, Gupta, VB, Gupta, VK, Gutierrez, RA, Haeuser, E, Halwani, R, Hamidi, S, Hanif, A, Haque, S, Harapan, H, Hargono, A, Hashi, A, Hassan, S, Hassanein, MH, Hassanipour, S, Hassankhani, H, Hay, S, Hayat, K, Hegazy, M, Heidari, G, Hezam, K, Holla, R, Hoque, ME, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Househ, M, Hsieh, VC-R, Huang, J, Humayun, A, Hussain, R, Hussein, NR, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Inamdar, S, Iqbal, U, Irham, LM, Irvani, SSN, Islam, SMS, Ismail, NE, Itumalla, R, Jha, RP, Joukar, F, Kabir, A, Kabir, Z, Kalhor, R, Kamal, Z, Kamande, SM, Kandel, H, Karch, A, Kassahun, G, Kassebaum, NJ, Katoto, PD, Kelkay, B, Kengne, AP, Khader, YS, Khajuria, H, Khalil, IA, Khan, EA, Khan, G, Khan, J, Khan, M, Ab Khan, M, Khang, Y-H, Khoja, AT, Khubchandani, J, Kim, GR, Kim, MS, Kim, YJ, Kimokoti, RW, Kisa, A, Kisa, S, Korshunov, VA, Kosen, S, Defo, BK, Kulkarni, V, Kumar, A, Kumar, GA, Kumar, N, Kwarteng, A, La Vecchia, C, Lami, FH, Landires, I, Lasrado, S, Lassi, ZS, Lee, H, Lee, YY, Levi, M, Lewycka, S, Li, S, Liu, X, Lobo, SW, Lopukhov, PD, Lozano, R, Saute, RL, Razek, MMAE, Makki, A, Malik, AA, Mansour-Ghanaei, F, Mansournia, MA, Mantovani, LG, Martins-Melo, FR, Matthews, PC, Medina, JRC, Mendoza, W, Menezes, RG, Mengesha, EW, Meretoja, TJ, Mersha, AG, Mesregah, MK, Mestrovic, T, Miazgowski, B, Milne, GJ, Mirica, A, Mirrakhimov, EM, Mirzaei, HR, Misra, S, Mithra, P, Moghadaszadeh, M, Mohamed, TA, Mohammad, KA, Mohammad, Y, Mohammadi, M, Mohammadian-Hafshejani, A, Mohammed, A, Mohammed, S, Mohapatra, A, Mokdad, AH, Molokhia, M, Monasta, L, Moni, MA, Al Montasir, A, Moore, CE, Moradi, G, Moradzadeh, R, Moraga, P, Mueller, UO, Munro, SB, Naghavi, M, Naimzada, MD, Naveed, M, Nayak, BP, Negoi, I, Kandel, SN, Nguyen, TH, Nikbakhsh, R, Ningrum, DNA, Nixon, MR, Nnaji, CA, Noubiap, JJ, Nunez-Samudio, V, Nwatah, VE, Oancea, B, Ochir, C, Ogbo, FA, Olagunju, AT, Olakunde, BO, Onwujekwe, OE, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Padubidri, JR, Pakshir, K, Park, E-C, Kan, FP, Pathak, M, Paudel, R, Pawar, S, Pereira, J, Peres, MFP, Perianayagam, A, Pinheiro, M, Pirestani, M, Podder, V, Polibin, R, Pollok, RCG, Postma, MJ, Pottoo, FH, Rabiee, M, Rabiee, N, Radfar, A, Rafiei, A, Rahimi-Movaghar, V, Rahman, M, Rahmani, AM, Rahmawaty, S, Rajesh, A, Ramshaw, RE, Ranasinghe, P, Rao, CR, Rao, SJ, Rathi, P, Rawaf, DL, Rawaf, S, Renzaho, AMN, Rezaei, N, Rezai, MS, Rios-Blancas, M, Rogowski, ELB, Ronfani, L, Rwegerera, GM, Saad, AM, Sabour, S, Saddik, B, Saeb, MR, Saeed, U, Sahebkar, A, Sahraian, MA, Salam, N, Salimzadeh, H, Samaei, M, Samy, AM, Sanabria, J, Sanmarchi, F, Santric-Milicevic, MM, Sartorius, B, Sarveazad, A, Sathian, B, Sawhney, M, Saxena, D, Saxena, S, Seidu, A-A, Seylani, A, Shaikh, MA, Shamsizadeh, M, Shetty, PH, Shigematsu, M, Shin, JI, Sidemo, NB, 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Yigit, V, Yirdaw, BW, Yon, DK, Yonemoto, N, Yu, C, Yuce, D, Yunusa, I, Zamani, M, Zamanian, M, Zewdie, DT, Zhang, Z-J, Zhong, C, Zumla, A, Murray, CJL, Lim, SS, and Mosser, JF
Abstract: BACKGROUND: Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilities. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time. METHODS: For this analysis we collated 55 326 country-specific, cohort-specific, year-specific, vaccine-specific, and dose-specific observations of routine childhood vaccination coverage between 1980 and 2019. Using spatiotemporal Gaussian process regression, we produced location-specific and year-specific estimates of 11 routine childhood vaccine coverage indicators for 204 countries and territories from 1980 to 2019, adjusting for biases in country-reported data and reflecting reported stockouts and supply disruptions. We analysed global and regional trends in coverage and numbers of zero-dose children (defined as those who never received a diphtheria-tetanus-pertussis [DTP] vaccine dose), progress towards GVAP targets, and the relationship between vaccine coverage and sociodemographic development. FINDINGS: By 2019, global coverage of third-dose DTP (DTP3; 81·6% [95% uncertainty interval 80·4-82·7]) more than doubled from levels estimated in 1980 (39·9% [37·5-42·1]), as did global coverage of the first-dose measles-containing vaccine (MCV1; from 38·5% [35·4-41·3] in 1980 to 83·6% [82·3-84·8] in 2019). Third-dose polio vaccine (Pol3) coverage also increased, from 42·6% (41·4-44·1) in 1980 to 79·8% (78·4-81·1) in 2019, and global coverage of newer vaccines increased rapidly between 2000 and 2019. The global number of zero-dose children fell by nearly 75% between 1980 and 2019
Published: 2021

17. Mapping routine measles vaccination in low- and middle-income countries

Author: Sbarra, AN, Rolfe, S, Nguyen, JQ, Earl, L, Galles, NC, Marks, A, Abbas, KM, Abbasi-Kangevari, M, Abbastabar, H, Abd-Allah, F, Abdelalim, A, Abdollahi, M, Abegaz, KH, Abiy, HAA, Abolhassani, H, Abreu, LG, Abrigo, MRM, Abushouk, AI, Accrombessi, MMK, Adabi, M, Adebayo, OM, Adekanmbi, V, Adetokunboh, OO, Adham, D, Afarideh, M, Aghaali, M, Ahmad, T, Ahmadi, R, Ahmadi, K, Ahmed, MB, Alanezi, FM, Alanzi, TM, Alcalde-Rabanal, JE, Alemnew, BT, Ali, BA, Ali, M, Alijanzadeh, M, Alinia, C, Alipoor, R, Alipour, V, Alizade, H, Aljunid, SM, Almasi, A, Almasi-Hashiani, A, Al-Mekhlafi, HM, Altirkawi, KA, Amare, B, Amini, S, Amini-Rarani, M, Amiri, F, Amit, AML, Amugsi, DA, Ancuceanu, R, Andrei, CL, Anjomshoa, M, Ansari, F, Ansari-Moghaddam, A, Ansha, MG, Antonio, CAT, Antriyandarti, E, Anvari, D, Arabloo, J, Arab-Zozani, M, Aremu, O, Armoon, B, Aryal, KK, Arzani, A, Asadi-Aliabadi, M, Asgari, S, Atafar, Z, Ausloos, M, Awoke, N, Quintanilla, BPA, Ayanore, MA, Aynalem, YA, Azadmehr, A, Azari, S, Babaee, E, Badawi, A, Badiye, AD, Bahrami, MA, Baig, AA, Bakhtiari, A, Balakrishnan, S, Banach, M, Banik, PC, Barac, A, Baradaran-Seyed, Z, Baraki, AG, Basu, S, Bayati, M, Bayou, YT, Bedi, N, Behzadifar, M, Bell, ML, Berbada, DA, Berhe, K, Bhattarai, S, Bhutta, ZA, Bijani, A, Birhanu, M, Bisanzio, D, Biswas, A, Bohlouli, S, Bolla, SR, Borzouei, S, Brady, OJ, Bragazzi, NL, Briko, AN, Briko, NI, Nagaraja, SB, Butt, ZA, Cámera, LA, Campos-Nonato, IR, Car, J, Cárdenas, R, Carvalho, F, Castaldelli-Maia, JM, Castro, F, Chattu, VK, Chehrazi, M, Chin, KL, Chu, D-T, Cook, AJ, Cormier, NM, Cunningham, B, Dahlawi, SMA, Damiani, G, Dandona, R, Dandona, L, Danovaro, MC, Dansereau, E, Daoud, F, Darwesh, AM, Darwish, AH, Das, JK, Weaver, ND, De Neve, J-W, Demeke, FM, Demis, AB, Denova-Gutiérrez, E, Desalew, A, Deshpande, A, Desta, DM, Dharmaratne, SD, Dhungana, GP, Dianatinasab, M, Diaz, D, Dipeolu, IO, Djalalinia, S, Do, HT, Dorostkar, F, Doshmangir, L, Doyle, KE, Dunachie, SJ, Duraes, AR, Kalan, 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Mohebi, F, Mokdad, AH, Monasta, L, Moosavi, MA, Moosazadeh, M, Moradi, G, Moradi, M, Moradi-Joo, M, Moradi-Lakeh, M, Moradzadeh, R, Moraga, P, Mosapour, A, Mouodi, S, Mousavi, SM, Khaneghah, AM, Mueller, UO, Muluneh, AG, Munro, SB, Murray, CJL, Murthy, GVS, Muthupandian, S, Naderi, M, Nagarajan, AJ, Naghavi, M, Nangia, V, Nansseu, JR, Nayak, VC, Nazari, J, Ndwandwe, DE, Negoi, I, Ngunjiri, JW, Nguyen, HLT, Nguyen, CTK, Nguyen, TH, Nigatu, YT, Nikbakhsh, R, Nikfar, S, Nikpoor, AR, Ningrum, DNA, Nnaji, CA, Oh, I-H, Oladnabi, M, Olagunju, AT, Olusanya, JO, Olusanya, BO, Bali, AO, Omer, MO, Onwujekwe, OE, Osgood-Zimmerman, AE, Owolabi, MO, P, A, M, Padubidri, JR, Pakshir, K, Pana, A, Pandey, A, Pando-Robles, V, Pashaei, T, Pasupula, DK, Paternina-Caicedo, AJ, Patton, GC, Pazoki Toroudi, H, Pepito, VCF, Pescarini, JM, Pigott, DM, Pilgrim, T, Pirsaheb, M, Poljak, M, Postma, MJ, Pourjafar, H, Pourmalek, F, Pourmirza, Kalhori, R, Prada, SI, Prakash, S, Quazi Syed, Z, Quintana, H, Rabiee, N, Rabiee, M, Radfar, A, Rafiei, A, Rahim, F, Rajati, F, Rameto, MA, Ramezanzadeh, K, Ranabhat, CL, Rao, SJ, Rasella, D, Rastogi, P, Rathi, P, Rawaf, S, Rawaf, DL, Rawal, L, Rawassizadeh, R, Rawat, R, Renjith, V, Renzaho, AMN, Reshmi, B, Reta, MA, Rezaei, N, Rezai, MS, Rezapour, A, Riahi, SM, Ribeiro, AI, Rickard, J, Rios-Blancas, M, Rios-González, CM, Roever, L, Rostamian, M, Rubino, S, Rwegerera, GM, Saad, AM, Saadatagah, S, Sabour, S, Sadeghi, E, Moghaddam, SS, Saeidi, S, Sagar, R, Sahebkar, A, Sahraian, MA, Sajadi, SM, Salahshoor, MR, Salam, N, Salem, H, Salem, MR, Salomon, JA, Kafil, HS, Sambala, EZ, Samy, AM, Saraswathy, SYI, Sarmiento-Suárez, R, Saroshe, S, Sartorius, B, Sarveazad, A, Sathian, B, Sathish, T, Schaeffer, LE, Schwebel, DC, Senthilkumaran, S, Shabaninejad, H, Shahabi, S, Shaheen, AA, Shaikh, MA, Shalash, AS, Shams-Beyranvand, M, Shamsi, MB, Shamsizadeh, M, Sharafi, K, Sharifi, H, Sheikh, A, Sheikhtaheri, A, Shetty, RS, Shiferaw, WS, Shigematsu, M, Shin, JI, Shirkoohi, R, Siabani, S, Siddiqi, TJ, Silverberg, JIS, Simonetti, B, Singh, JA, Sinha, DN, Sinke, AH, Soheili, A, Sokhan, A, Soltani, S, Soofi, M, Sorrie, MB, Soyiri, IN, Spotin, A, Spurlock, EE, Sreeramareddy, CT, Sudaryanto, A, Sufiyan, MB, Suleria, HAR, Abdulkader, RS, Taherkhani, A, Tapak, L, Taveira, N, Taymoori, P, Tefera, YM, Tehrani-Banihashemi, A, Teklehaimanot, BF, Tekulu, GH, Tesfay, BE, Tessema, ZT, Tessema, B, Thankappan, KR, Tohidinik, HR, Topor-Madry, R, Tovani-Palone, MR, Tran, BX, Uddin, R, Ullah, I, Umeokonkwo, CD, Unnikrishnan, B, Upadhyay, E, Usman, MS, Vaezi, M, Valadan, Tahbaz, S, Valdez, PR, Vasseghian, Y, Veisani, Y, Violante, FS, Vollmer, S, Waheed, Y, Wakefield, J, Wang, Y, Wang, Y-P, Weldesamuel, GT, Werdecker, A, Westerman, R, Wiangkham, T, Wiens, KE, Wiysonge, CS, Woldu, G, Wondafrash, DZ, Wonde, TE, Wu, A-M, Yadollahpour, A, Jabbari, SHY, Yamada, T, Yaya, S, Yazdi-Feyzabadi, V, Yeheyis, TY, Yeshaw, Y, Yilgwan, CS, Yip, P, Yonemoto, N, Younis, MZ, Yousefi, Z, Yousefifard, M, Yousefinezhadi, T, Yu, C, Yusefzadeh, H, Zadey, S, Zahirian, Moghadam, T, Zaki, L, Zaman, SB, Zamani, M, Zamanian, M, Zandian, H, Zangeneh, A, Zarei, F, Zerfu, TA, Zhang, Y, Zhang, Z-J, Zhao, X-JG, Zhou, M, Ziapour, A, Hay, SI, Lim, SS, Mosser, JF, Local Burden of Disease Vaccine Coverage Collaborators, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), HUS Comprehensive Cancer Center, Clinicum, Department of Oncology, Sbarra, Alyssa N., Rolfe, Sam, Nguyen, Jason Q., Earl, Lucas, Ahmed, MB, Mosser, Jonathan F, Collaborators, Local Burden of Disease Vaccine Coverage, Bill & Melinda Gates Foundation, Alexander von Humboldt-Stiftung, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Universiti Sains Malaysia (Malasia), Panjab University (India), NIHR - Oxford Biomedical Research Centre (Reino Unido), Australian Research Council, Instituto de Saúde Pública da Universidade do Porto, Local Burden Dis Educ Attainment C, Local Burden of Disease Vaccine Coverage Collaborator, and Violante FS
Subjects: and promotion of well-being, Vacunación Masiva, Internationality, Disease prevention, children under 5 years old, Geographic Mapping, Rural Health, medicine.disease_cause, Cross-reactivity, 0302 clinical medicine, RA0421, Vaccination Refusal, 030212 general & internal medicine, Child, immunity patterns, Pediatric, 0303 health sciences, Public health, Multidisciplinary, biology, Vaccination, Uncertainty, IMMUNIZATION, 3142 Public health care science, environmental and occupational health, COVERAGE, 3. Good health, TIME, 3.4 Vaccines, Child, Preschool, Infectious diseases, A990 Medicine and Dentistry not elsewhere classified, Antibody, Engineering sciences. Technology, AFRICA, General Science & Technology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, 610 Medicine & health, Global Vaccine Action Plan (GVAP), Local Burden of Disease Vaccine Coverage Collaborators, Article, Vaccine Related, 03 medical and health sciences, measles vaccine, Measels, Low- and middle-income countries, Local burden of disease, Clinical Research, medicine, Humans, Healthcare Disparities, Preschool, PROGRESS, 030304 developmental biology, business.industry, MORTALITY, Developed Countries, Prevention, Comment, Vacunación, Urban Health, Prevention of disease and conditions, Virology, Coronavirus, Good Health and Well Being, Cobertura de Vacunación, biology.protein, Immunization, business, Measles
Abstract: The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2 pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children., Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.
Published: 2021

18. The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Author: Sepanlou, S, Safiri, S, Bisignano, C, Ikuta, K, Merat, S, Saberifiroozi, M, Poustchi, H, Tsoi, D, Colombara, D, Abdoli, A, Adedoyin, R, Afarideh, M, Agrawal, S, Ahmad, S, Ahmadian, E, Ahmadpour, E, Akinyemiju, T, Akunna, C, Alipour, V, Almasi-Hashiani, A, Almulhim, A, Al-Raddadi, R, Alvis-Guzman, N, Anber, N, Angus, C, Anoushiravani, A, Arabloo, J, Araya, E, Asmelash, D, Ataeinia, B, Ataro, Z, Atout, M, Ausloos, F, Awasthi, A, Badawi, A, Banach, M, Bejarano Ramirez, D, Bhagavathula, A, Bhala, N, Bhattacharyya, K, Biondi, A, Bolla, S, Boloor, A, Borzì, A, Butt, Z, Cámera, L, Campos-Nonato, I, Carvalho, F, Chu, D, Chung, S, Cortesi, P, Costa, V, Cowie, B, Daryani, A, de Courten, B, Demoz, G, Desai, R, Dharmaratne, S, Djalalinia, S, Do, H, Dorostkar, F, Drake, T, Dubey, M, Duncan, B, Effiong, A, Eftekhari, A, Elsharkawy, A, Etemadi, A, Farahmand, M, Farzadfar, F, Fernandes, E, Filip, I, Fischer, F, Gebremedhin, K, Geta, B, Gilani, S, Gill, P, Gutirrez, R, Haile, M, Haj-Mirzaian, A, Hamid, S, Hasankhani, M, Hasanzadeh, A, Hashemian, M, Hassen, H, Hay, S, Hayat, K, Heidari, B, Henok, A, Hoang, C, Hostiuc, M, Hostiuc, S, Hsieh, V, Igumbor, E, Ilesanmi, O, Irvani, S, Jafari Balalami, N, James, S, Jeemon, P, Jha, R, Jonas, J, Jozwiak, J, Kabir, A, Kasaeian, A, Kassaye, H, Kefale, A, Khalilov, R, Khan, M, Khan, E, Khater, A, Kim, Y, Koyanagi, A, La Vecchia, C, Lim, L, Lopez, A, Lorkowski, S, Lotufo, P, Lozano, R, Magdy Abd El Razek, M, Mai, H, Manafi, N, Manafi, A, Mansournia, M, Mantovani, L, Mazzaglia, G, Mehta, D, Mendoza, W, Menezes, R, Mengesha, M, Meretoja, T, Mestrovic, T, Miazgowski, B, Miller, T, Mirrakhimov, E, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohammadian-Hafshejani, A, Mohammed, S, Mokdad, A, Montero-Zamora, P, Moradi, G, Naimzada, M, Nayak, V, Negoi, I, Nguyen, T, Ofori-Asenso, R, Oh, I, Olagunju, T, Padubidri, J, Pakshir, K, Pana, A, Pathak, M, Pourshams, A, Rabiee, N, Radfar, A, Rafiei, A, Ramezanzadeh, K, Rana, S, Rawaf, S, Rawaf, D, Reiner RC, J, Roever, L, Room, R, Roshandel, G, Safari, S, Samy, A, Sanabria, J, Sartorius, B, Schmidt, M, Senthilkumaran, S, Shaikh, M, Sharif, M, Sharifi, A, Shigematsu, M, Singh, J, Soheili, A, Suleria, H, Teklehaimanot, B, Tesfay, B, Vacante, M, Vahedian-Azimi, A, Valdez, P, Vasankari, T, Vu, G, Waheed, Y, Weldegwergs, K, Werdecker, A, Westerman, R, Wondafrash, D, Wondmieneh, A, Yeshitila, Y, Yonemoto, N, Yu, C, Zaidi, Z, Zarghi, A, Zelber-Sagi, S, Zewdie, K, Zhang, Z, Zhao, X, Naghavi, M, Malekzadeh, R, Sepanlou SG, Safiri S, Bisignano C, Ikuta KS, Merat S, Saberifiroozi M, Poustchi H, Tsoi D, Colombara DV, Abdoli A, Adedoyin RA, Afarideh M, Agrawal S, Ahmad S, Ahmadian E, Ahmadpour E, Akinyemiju T, Akunna CJ, Alipour V, Almasi-Hashiani A, Almulhim AM, Al-Raddadi RM, Alvis-Guzman N, Anber NH, Angus C, Anoushiravani A, Arabloo J, Araya EM, Asmelash D, Ataeinia B, Ataro Z, Atout MMW, Ausloos F, Awasthi A, Badawi A, Banach M, Bejarano Ramirez DF, Bhagavathula AS, Bhala N, Bhattacharyya K, Biondi A, Bolla SR, Boloor A, Borzì AM, Butt ZA, Cámera LA, Campos-Nonato IR, Carvalho F, Chu DT, Chung SC, Cortesi PA, Costa VM, Cowie BC, Daryani A, de Courten B, Demoz GT, Desai R, Dharmaratne SD, Djalalinia S, Do HT, Dorostkar F, Drake TM, Dubey M, Duncan BB, Effiong A, Eftekhari A, Elsharkawy A, Etemadi A, Farahmand M, Farzadfar F, Fernandes E, Filip I, Fischer F, Gebremedhin KBB, Geta B, Gilani SA, Gill PS, Gutirrez RA, Haile MT, Haj-Mirzaian A, Hamid SS, Hasankhani M, Hasanzadeh A, Hashemian M, Hassen HY, Hay SI, Hayat K, Heidari B, Henok A, Hoang CL, Hostiuc M, Hostiuc S, Hsieh VC, Igumbor EU, Ilesanmi OS, Irvani SSN, Jafari Balalami N, James SL, Jeemon P, Jha RP, Jonas JB, Jozwiak JJ, Kabir A, Kasaeian A, Kassaye HG, Kefale AT, Khalilov R, Khan MA, Khan EA, Khater A, Kim YJ, Koyanagi A, La Vecchia C, Lim LL, Lopez AD, Lorkowski S, Lotufo PA, Lozano R, Magdy Abd El Razek M, Mai HT, Manafi N, Manafi A, Mansournia MA, Mantovani LG, Mazzaglia G, Mehta D, Mendoza W, Menezes RG, Mengesha MM, Meretoja TJ, Mestrovic T, Miazgowski B, Miller TR, Mirrakhimov EM, Mithra P, Moazen B, Moghadaszadeh M, Mohammadian-Hafshejani A, Mohammed S, Mokdad AH, Montero-Zamora PA, Moradi G, Naimzada MD, Nayak V, Negoi I, Nguyen TH, Ofori-Asenso R, Oh IH, Olagunju TO, Padubidri JR, Pakshir K, Pana A, Pathak M, Pourshams A, Rabiee N, Radfar A, Rafiei A, Ramezanzadeh K, Rana SMM, Rawaf S, Rawaf DL, Reiner RC Jr, Roever L, Room R, Roshandel G, Safari S, Samy AM, Sanabria J, Sartorius B, Schmidt MI, Senthilkumaran S, Shaikh MA, Sharif M, Sharifi A, Shigematsu M, Singh JA, Soheili A, Suleria HAR, Teklehaimanot BF, Tesfay BE, Vacante M, Vahedian-Azimi A, Valdez PR, Vasankari TJ, Vu GT, Waheed Y, Weldegwergs KG, Werdecker A, Westerman R, Wondafrash DZ, Wondmieneh AB, Yeshitila YG, Yonemoto N, Yu C, Zaidi Z, Zarghi A, Zelber-Sagi S, Zewdie KA, Zhang ZJ, Zhao XJ, Naghavi M, Malekzadeh R., Sepanlou, S, Safiri, S, Bisignano, C, Ikuta, K, Merat, S, Saberifiroozi, M, Poustchi, H, Tsoi, D, Colombara, D, Abdoli, A, Adedoyin, R, Afarideh, M, Agrawal, S, Ahmad, S, Ahmadian, E, Ahmadpour, E, Akinyemiju, T, Akunna, C, Alipour, V, Almasi-Hashiani, A, Almulhim, A, Al-Raddadi, R, Alvis-Guzman, N, Anber, N, Angus, C, Anoushiravani, A, Arabloo, J, Araya, E, Asmelash, D, Ataeinia, B, Ataro, Z, Atout, M, Ausloos, F, Awasthi, A, Badawi, A, Banach, M, Bejarano Ramirez, D, Bhagavathula, A, Bhala, N, Bhattacharyya, K, Biondi, A, Bolla, S, Boloor, A, Borzì, A, Butt, Z, Cámera, L, Campos-Nonato, I, Carvalho, F, Chu, D, Chung, S, Cortesi, P, Costa, V, Cowie, B, Daryani, A, de Courten, B, Demoz, G, Desai, R, Dharmaratne, S, Djalalinia, S, Do, H, Dorostkar, F, Drake, T, Dubey, M, Duncan, B, Effiong, A, Eftekhari, A, Elsharkawy, A, Etemadi, A, Farahmand, M, Farzadfar, F, Fernandes, E, Filip, I, Fischer, F, Gebremedhin, K, Geta, B, Gilani, S, Gill, P, Gutirrez, R, Haile, M, Haj-Mirzaian, A, Hamid, S, Hasankhani, M, Hasanzadeh, A, Hashemian, M, Hassen, H, Hay, S, Hayat, K, Heidari, B, Henok, A, Hoang, C, Hostiuc, M, Hostiuc, S, Hsieh, V, Igumbor, E, Ilesanmi, O, Irvani, S, Jafari Balalami, N, James, S, Jeemon, P, Jha, R, Jonas, J, Jozwiak, J, Kabir, A, Kasaeian, A, Kassaye, H, Kefale, A, Khalilov, R, Khan, M, Khan, E, Khater, A, Kim, Y, Koyanagi, A, La Vecchia, C, Lim, L, Lopez, A, Lorkowski, S, Lotufo, P, Lozano, R, Magdy Abd El Razek, M, Mai, H, Manafi, N, Manafi, A, Mansournia, M, Mantovani, L, Mazzaglia, G, Mehta, D, Mendoza, W, Menezes, R, Mengesha, M, Meretoja, T, Mestrovic, T, Miazgowski, B, Miller, T, Mirrakhimov, E, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohammadian-Hafshejani, A, Mohammed, S, Mokdad, A, Montero-Zamora, P, Moradi, G, Naimzada, M, Nayak, V, Negoi, I, Nguyen, T, Ofori-Asenso, R, Oh, I, Olagunju, T, Padubidri, J, Pakshir, K, Pana, A, Pathak, M, Pourshams, A, Rabiee, N, Radfar, A, Rafiei, A, Ramezanzadeh, K, Rana, S, Rawaf, S, Rawaf, D, Reiner RC, J, Roever, L, Room, R, Roshandel, G, Safari, S, Samy, A, Sanabria, J, Sartorius, B, Schmidt, M, Senthilkumaran, S, Shaikh, M, Sharif, M, Sharifi, A, Shigematsu, M, Singh, J, Soheili, A, Suleria, H, Teklehaimanot, B, Tesfay, B, Vacante, M, Vahedian-Azimi, A, Valdez, P, Vasankari, T, Vu, G, Waheed, Y, Weldegwergs, K, Werdecker, A, Westerman, R, Wondafrash, D, Wondmieneh, A, Yeshitila, Y, Yonemoto, N, Yu, C, Zaidi, Z, Zarghi, A, Zelber-Sagi, S, Zewdie, K, Zhang, Z, Zhao, X, Naghavi, M, Malekzadeh, R, Sepanlou SG, Safiri S, Bisignano C, Ikuta KS, Merat S, Saberifiroozi M, Poustchi H, Tsoi D, Colombara DV, Abdoli A, Adedoyin RA, Afarideh M, Agrawal S, Ahmad S, Ahmadian E, Ahmadpour E, Akinyemiju T, Akunna CJ, Alipour V, Almasi-Hashiani A, Almulhim AM, Al-Raddadi RM, Alvis-Guzman N, Anber NH, Angus C, Anoushiravani A, Arabloo J, Araya EM, Asmelash D, Ataeinia B, Ataro Z, Atout MMW, Ausloos F, Awasthi A, Badawi A, Banach M, Bejarano Ramirez DF, Bhagavathula AS, Bhala N, Bhattacharyya K, Biondi A, Bolla SR, Boloor A, Borzì AM, Butt ZA, Cámera LA, Campos-Nonato IR, Carvalho F, Chu DT, Chung SC, Cortesi PA, Costa VM, Cowie BC, Daryani A, de Courten B, Demoz GT, Desai R, Dharmaratne SD, Djalalinia S, Do HT, Dorostkar F, Drake TM, Dubey M, Duncan BB, Effiong A, Eftekhari A, Elsharkawy A, Etemadi A, Farahmand M, Farzadfar F, Fernandes E, Filip I, Fischer F, Gebremedhin KBB, Geta B, Gilani SA, Gill PS, Gutirrez RA, Haile MT, Haj-Mirzaian A, Hamid SS, Hasankhani M, Hasanzadeh A, Hashemian M, Hassen HY, Hay SI, Hayat K, Heidari B, Henok A, Hoang CL, Hostiuc M, Hostiuc S, Hsieh VC, Igumbor EU, Ilesanmi OS, Irvani SSN, Jafari Balalami N, James SL, Jeemon P, Jha RP, Jonas JB, Jozwiak JJ, Kabir A, Kasaeian A, Kassaye HG, Kefale AT, Khalilov R, Khan MA, Khan EA, Khater A, Kim YJ, Koyanagi A, La Vecchia C, Lim LL, Lopez AD, Lorkowski S, Lotufo PA, Lozano R, Magdy Abd El Razek M, Mai HT, Manafi N, Manafi A, Mansournia MA, Mantovani LG, Mazzaglia G, Mehta D, Mendoza W, Menezes RG, Mengesha MM, Meretoja TJ, Mestrovic T, Miazgowski B, Miller TR, Mirrakhimov EM, Mithra P, Moazen B, Moghadaszadeh M, Mohammadian-Hafshejani A, Mohammed S, Mokdad AH, Montero-Zamora PA, Moradi G, Naimzada MD, Nayak V, Negoi I, Nguyen TH, Ofori-Asenso R, Oh IH, Olagunju TO, Padubidri JR, Pakshir K, Pana A, Pathak M, Pourshams A, Rabiee N, Radfar A, Rafiei A, Ramezanzadeh K, Rana SMM, Rawaf S, Rawaf DL, Reiner RC Jr, Roever L, Room R, Roshandel G, Safari S, Samy AM, Sanabria J, Sartorius B, Schmidt MI, Senthilkumaran S, Shaikh MA, Sharif M, Sharifi A, Shigematsu M, Singh JA, Soheili A, Suleria HAR, Teklehaimanot BF, Tesfay BE, Vacante M, Vahedian-Azimi A, Valdez PR, Vasankari TJ, Vu GT, Waheed Y, Weldegwergs KG, Werdecker A, Westerman R, Wondafrash DZ, Wondmieneh AB, Yeshitila YG, Yonemoto N, Yu C, Zaidi Z, Zarghi A, Zelber-Sagi S, Zewdie KA, Zhang ZJ, Zhao XJ, Naghavi M, and Malekzadeh R.
Abstract: Background: Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 on the burden of cirrhosis and its trends since 1990, by cause, sex, and age, for 195 countries and territories. Methods: We used data from vital registrations, vital registration samples, and verbal autopsies to estimate mortality. We modelled prevalence of total, compensated, and decompensated cirrhosis on the basis of hospital and claims data. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost due to premature death and years lived with disability. Estimates are presented as numbers and age-standardised or age-specific rates per 100 000 population, with 95% uncertainty intervals (UIs). All estimates are presented for five causes of cirrhosis: hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis (NASH), and other causes. We compared mortality, prevalence, and DALY estimates with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries. Findings: In 2017, cirrhosis caused more than 1·32 million (95% UI 1·27–1·45) deaths (440 000 [416 000–518 000; 33·3%] in females and 883 000 [838 000–967 000; 66·7%] in males) globally, compared with less than 899 000 (829 000–948 000) deaths in 1990. Deaths due to cirrhosis constituted 2·4% (2·3–2·6) of total deaths globally in 2017 compared with 1·9% (1·8–2·0) in 1990. Despite an increase in the number of deaths, the age-standardised death rate decreased from 21·0 (19·2–22·3) per 100 000 population in 1990 to 16·5 (15·8–18·1) per 100 000 population in 2017. Sub-Saharan Africa had the highest age-standardised death rate among GBD super-regions fo
Published: 2020

19. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

Author: Roth, GA, Mensah, GA, Johnson, CO, Addolorato, G, Ammirati, E, Baddour, LM, Barengo, NC, Beaton, AZ, Benjamin, EJ, Benziger, CP, Bonny, A, Brauer, M, Brodmann, M, Cahill, TJ, Carapetis, J, Catapano, AL, Chugh, SS, Cooper, LT, Coresh, J, Criqui, M, DeCleene, N, Eagle, KA, Emmons-Bell, S, Feigin, VL, Fernández-Solà, J, Fowkes, G, Gakidou, E, Grundy, SM, He, FJ, Howard, G, Hu, F, Inker, L, Karthikeyan, G, Kassebaum, N, Koroshetz, W, Lavie, C, Lloyd-Jones, D, Lu, HS, Mirijello, A, Temesgen, AM, Mokdad, A, Moran, AE, Muntner, P, Narula, J, Neal, B, Ntsekhe, M, Moraes de Oliveira, G, Otto, C, Owolabi, M, Pratt, M, Rajagopalan, S, Reitsma, M, Ribeiro, ALP, Rigotti, N, Rodgers, A, Sable, C, Shakil, S, Sliwa-Hahnle, K, Stark, B, Sundström, J, Timpel, P, Tleyjeh, IM, Valgimigli, M, Vos, T, Whelton, PK, Yacoub, M, Zuhlke, L, Murray, C, Fuster, V, Beaton, A, Carapetis, JR, Chugh, S, Criqui, MH, DeCleene, NK, Fernández-Sola, J, Fowkes, FGR, Kassebaum, NJ, Koroshetz, WJ, Misganaw, AT, Mokdad, AH, Oliveira, GMM, Otto, CM, Owolabi, MO, Reitsma, MB, Rigotti, NA, Sable, CA, Shakil, SS, Sliwa, K, Stark, BA, Tleyjeh, II, Zuhlke, LJ, Abbasi-Kangevari, M, Abdi, A, Abedi, A, Aboyans, V, Abrha, WA, Abu-Gharbieh, E, Abushouk, AI, Acharya, D, Adair, T, Adebayo, OM, Ademi, Z, Advani, SM, Afshari, K, Afshin, A, Agarwal, G, Agasthi, P, Ahmad, S, Ahmadi, S, Ahmed, MB, Aji, B, Akalu, Y, Akande-Sholabi, W, Aklilu, A, Akunna, CJ, Alahdab, F, Al-Eyadhy, A, Alhabib, KF, Alif, SM, Alipour, V, Aljunid, SM, Alla, F, Almasi-Hashiani, A, Almustanyir, S, Al-Raddadi, RM, Amegah, AK, Amini, S, Aminorroaya, A, Amu, H, Amugsi, DA, Ancuceanu, R, Anderlini, D, Andrei, T, Andrei, CL, Ansari-Moghaddam, A, Anteneh, ZA, Antonazzo, IC, Antony, B, Anwer, R, Appiah, LT, Arabloo, J, Ärnlöv, J, Artanti, KD, Ataro, Z, Ausloos, M, Avila-Burgos, L, Awan, AT, Awoke, MA, Ayele, HT, Ayza, MA, Azari, S, B, DB, Baheiraei, N, Baig, AA, Bakhtiari, A, Banach, M, Banik, PC, Baptista, EA, Barboza, MA, Barua, L, Basu, S, Bedi, N, Béjot, Y, Bennett, DA, Bensenor, IM, Berman, AE, Bezabih, YM, Bhagavathula, AS, Bhaskar, S, Bhattacharyya, K, Bijani, A, Bikbov, B, Birhanu, MM, Boloor, A, Brant, LC, Brenner, H, Briko, NI, Butt, ZA, Caetano dos Santos, FL, Cahill, LE, Cahuana-Hurtado, L, Cámera, LA, Campos-Nonato, IR, Cantu-Brito, C, Car, J, Carrero, JJ, Carvalho, F, Castañeda-Orjuela, CA, Catalá-López, F, Cerin, E, Charan, J, Chattu, VK, Chen, S, Chin, KL, Choi, J-YJ, Chu, D-T, Chung, S-C, Cirillo, M, Coffey, S, Conti, S, Costa, VM, Cundiff, DK, Dadras, O, Dagnew, B, Dai, X, Damasceno, AAM, Dandona, L, Dandona, R, Davletov, K, De la Cruz-Góngora, V, De la Hoz, FP, De Neve, J-W, Denova-Gutiérrez, E, Derbew Molla, M, Derseh, BT, Desai, R, Deuschl, G, Dharmaratne, SD, Dhimal, M, Dhungana, RR, Dianatinasab, M, Diaz, D, Djalalinia, S, Dokova, K, Douiri, A, Duncan, BB, Duraes, AR, Eagan, AW, Ebtehaj, S, Eftekhari, A, Eftekharzadeh, S, Ekholuenetale, M, El Nahas, N, Elgendy, IY, Elhadi, M, El-Jaafary, SI, Esteghamati, S, Etisso, AE, Eyawo, O, Fadhil, I, Faraon, EJA, Faris, PS, Farwati, M, Farzadfar, F, Fernandes, E, Fernandez Prendes, C, Ferrara, P, Filip, I, Fischer, F, Flood, D, Fukumoto, T, Gad, MM, Gaidhane, S, Ganji, M, Garg, J, Gebre, AK, Gebregiorgis, BG, Gebregzabiher, KZ, Gebremeskel, GG, Getacher, L, Obsa, AG, Ghajar, A, Ghashghaee, A, Ghith, N, Giampaoli, S, Gilani, SA, Gill, PS, Gillum, RF, Glushkova, EV, Gnedovskaya, EV, Golechha, M, Gonfa, KB, Goudarzian, AH, Goulart, AC, Guadamuz, JS, Guha, A, Guo, Y, Gupta, R, Hachinski, V, Hafezi-Nejad, N, Haile, TG, Hamadeh, RR, Hamidi, S, Hankey, GJ, Hargono, A, Hartono, RK, Hashemian, M, Hashi, A, Hassan, S, Hassen, HY, Havmoeller, RJ, Hay, SI, Hayat, K, Heidari, G, Herteliu, C, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Iavicoli, I, Ibeneme, CU, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Iqbal, U, Irvani, SSN, Shariful Islam, Sheikh, Islam, RM, Iso, H, Iwagami, M, Jain, V, Javaheri, T, Jayapal, SK, Jayaram, S, Jayawardena, R, Jeemon, P, Jha, RP, Jonas, JB, Jonnagaddala, J, Joukar, F, Jozwiak, JJ, Jürisson, M, Kabir, A, Kahlon, T, Kalani, R, Kalhor, R, Kamath, A, Kamel, I, Kandel, H, Kandel, A, Karch, A, Kasa, AS, Katoto, PDMC, Kayode, GA, Khader, YS, Khammarnia, M, Khan, MS, Khan, MN, Khan, M, Khan, EA, Khatab, K, Kibria, GMA, Kim, YJ, Kim, GR, Kimokoti, RW, Kisa, S, Kisa, A, Kivimäki, M, Kolte, D, Koolivand, A, Korshunov, VA, Koulmane Laxminarayana, SL, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Kuate Defo, B, Kucuk Bicer, B, Kulkarni, V, Kumar, GA, Kumar, N, Kurmi, OP, Kusuma, D, Kwan, GF, La Vecchia, C, Lacey, B, Lallukka, T, Lan, Q, Lasrado, S, Lassi, ZS, Lauriola, P, Lawrence, WR, Laxmaiah, A, LeGrand, KE, Li, M-C, Li, B, Li, S, Lim, SS, Lim, L-L, Lin, H, Lin, Z, Lin, R-T, Liu, X, Lopez, AD, Lorkowski, S, Lotufo, PA, Lugo, A, M, NK, Madotto, F, Mahmoudi, M, Majeed, A, Malekzadeh, R, Malik, AA, Mamun, AA, Manafi, N, Mansournia, MA, Mantovani, LG, Martini, S, Mathur, MR, Mazzaglia, G, Mehata, S, Mehndiratta, MM, Meier, T, Menezes, RG, Meretoja, A, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirrakhimov, EM, Mirzaei, H, Moazen, B, Moghadaszadeh, M, Mohammad, Y, Mohammad, DK, Mohammed, S, Mohammed, MA, Mokhayeri, Y, Molokhia, M, Montasir, AA, Moradi, G, Moradzadeh, R, Moraga, P, Morawska, L, Moreno Velásquez, I, Morze, J, Mubarik, S, Muruet, W, Musa, KI, Nagarajan, AJ, Nalini, M, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Nascimento, BR, Nayak, VC, Nazari, J, Nazarzadeh, M, Negoi, RI, Neupane Kandel, S, Nguyen, HLT, Nixon, MR, Norrving, B, Noubiap, JJ, Nouthe, BE, Nowak, C, Odukoya, OO, Ogbo, FA, Olagunju, AT, Orru, H, Ortiz, A, Ostroff, SM, Padubidri, JR, Palladino, R, Pana, A, Panda-Jonas, S, Parekh, U, Park, E-C, Parvizi, M, Pashazadeh Kan, F, Patel, UK, Pathak, M, Paudel, R, Pepito, VCF, Perianayagam, A, Perico, N, Pham, HQ, Pilgrim, T, Piradov, MA, Pishgar, F, Podder, V, Polibin, RV, Pourshams, A, Pribadi, DRA, Rabiee, N, Rabiee, M, Radfar, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Ur Rahman, MH, Rahman, Muhammad, Rahmani, AM, Rakovac, I, Ram, P, Ramalingam, S, Rana, J, Ranasinghe, P, Rao, SJ, Rathi, P, Rawal, L, Rawasia, WF, Rawassizadeh, R, Remuzzi, G, Renzaho, AMN, Rezapour, A, Riahi, SM, Roberts-Thomson, RL, Roever, L, Rohloff, P, Romoli, M, Roshandel, G, Rwegerera, GM, Saadatagah, S, Saber-Ayad, MM, Sabour, S, Sacco, S, Sadeghi, M, Saeedi Moghaddam, S, Safari, S, Sahebkar, A, Salehi, S, Salimzadeh, H, Samaei, M, Samy, AM, Santos, IS, Santric-Milicevic, MM, Sarrafzadegan, N, Sarveazad, A, Sathish, T, Sawhney, M, Saylan, M, Schmidt, MI, Schutte, AE, Senthilkumaran, S, Sepanlou, SG, Sha, F, Shahabi, S, Shahid, I, Shaikh, MA, Shamali, M, Shamsizadeh, M, Shawon, MSR, Sheikh, A, Shigematsu, M, Shin, M-J, Shin, JI, Shiri, R, Shiue, I, Shuval, K, Siabani, S, Siddiqi, TJ, Silva, DAS, Singh, JA, Mtech, AS, Skryabin, VY, Skryabina, AA, Soheili, A, Spurlock, EE, Stockfelt, L, Stortecky, S, Stranges, S, Suliankatchi Abdulkader, R, Tadbiri, H, Tadesse, EG, Tadesse, DB, Tajdini, M, Tariqujjaman, M, Teklehaimanot, BF, Temsah, M-H, Tesema, AK, Thakur, B, Thankappan, KR, Thapar, R, Thrift, AG, Timalsina, B, Tonelli, M, Touvier, M, Tovani-Palone, MR, Tripathi, A, Tripathy, JP, Truelsen, TC, Tsegay, GM, Tsegaye, GW, Tsilimparis, N, Tusa, BS, Tyrovolas, S, Umapathi, KK, Unim, B, Unnikrishnan, B, Usman, MS, Vaduganathan, M, Valdez, PR, Vasankari, TJ, Velazquez, DZ, Venketasubramanian, N, Vu, GT, Vujcic, IS, Waheed, Y, Wang, Y, Wang, F, Wei, J, Weintraub, RG, Weldemariam, AH, Westerman, R, Winkler, AS, Wiysonge, CS, Wolfe, CDA, Wubishet, BL, Xu, G, Yadollahpour, A, Yamagishi, K, Yan, LL, Yandrapalli, S, Yano, Y, Yatsuya, H, Yeheyis, TY, Yeshaw, Y, Yilgwan, CS, Yonemoto, N, Yu, C, Yusefzadeh, H, Zachariah, G, Zaman, SB, Zaman, MS, Zamanian, M, Zand, R, Zandifar, A, Zarghi, A, Zastrozhin, MS, Zastrozhina, A, Zhang, Z-J, Zhang, Y, Zhang, W, Zhong, C, Zou, Z, Zuniga, YMH, Murray, CJL, Roth, GA, Mensah, GA, Johnson, CO, Addolorato, G, Ammirati, E, Baddour, LM, Barengo, NC, Beaton, AZ, Benjamin, EJ, Benziger, CP, Bonny, A, Brauer, M, Brodmann, M, Cahill, TJ, Carapetis, J, Catapano, AL, Chugh, SS, Cooper, LT, Coresh, J, Criqui, M, DeCleene, N, Eagle, KA, Emmons-Bell, S, Feigin, VL, Fernández-Solà, J, Fowkes, G, Gakidou, E, Grundy, SM, He, FJ, Howard, G, Hu, F, Inker, L, Karthikeyan, G, Kassebaum, N, Koroshetz, W, Lavie, C, Lloyd-Jones, D, Lu, HS, Mirijello, A, Temesgen, AM, Mokdad, A, Moran, AE, Muntner, P, Narula, J, Neal, B, Ntsekhe, M, Moraes de Oliveira, G, Otto, C, Owolabi, M, Pratt, M, Rajagopalan, S, Reitsma, M, Ribeiro, ALP, Rigotti, N, Rodgers, A, Sable, C, Shakil, S, Sliwa-Hahnle, K, Stark, B, Sundström, J, Timpel, P, Tleyjeh, IM, Valgimigli, M, Vos, T, Whelton, PK, Yacoub, M, Zuhlke, L, Murray, C, Fuster, V, Beaton, A, Carapetis, JR, Chugh, S, Criqui, MH, DeCleene, NK, Fernández-Sola, J, Fowkes, FGR, Kassebaum, NJ, Koroshetz, WJ, Misganaw, AT, Mokdad, AH, Oliveira, GMM, Otto, CM, Owolabi, MO, Reitsma, MB, Rigotti, NA, Sable, CA, Shakil, SS, Sliwa, K, Stark, BA, Tleyjeh, II, Zuhlke, LJ, Abbasi-Kangevari, M, Abdi, A, Abedi, A, Aboyans, V, Abrha, WA, Abu-Gharbieh, E, Abushouk, AI, Acharya, D, Adair, T, Adebayo, OM, Ademi, Z, Advani, SM, Afshari, K, Afshin, A, Agarwal, G, Agasthi, P, Ahmad, S, Ahmadi, S, Ahmed, MB, Aji, B, Akalu, Y, Akande-Sholabi, W, Aklilu, A, Akunna, CJ, Alahdab, F, Al-Eyadhy, A, Alhabib, KF, Alif, SM, Alipour, V, Aljunid, SM, Alla, F, Almasi-Hashiani, A, Almustanyir, S, Al-Raddadi, RM, Amegah, AK, Amini, S, Aminorroaya, A, Amu, H, Amugsi, DA, Ancuceanu, R, Anderlini, D, Andrei, T, Andrei, CL, Ansari-Moghaddam, A, Anteneh, ZA, Antonazzo, IC, Antony, B, Anwer, R, Appiah, LT, Arabloo, J, Ärnlöv, J, Artanti, KD, Ataro, Z, Ausloos, M, Avila-Burgos, L, Awan, AT, Awoke, MA, Ayele, HT, Ayza, MA, Azari, S, B, DB, Baheiraei, N, Baig, AA, Bakhtiari, A, Banach, M, Banik, PC, Baptista, EA, Barboza, MA, Barua, L, Basu, S, Bedi, N, Béjot, Y, Bennett, DA, Bensenor, IM, Berman, AE, Bezabih, YM, Bhagavathula, AS, Bhaskar, S, Bhattacharyya, K, Bijani, A, Bikbov, B, Birhanu, MM, Boloor, A, Brant, LC, Brenner, H, Briko, NI, Butt, ZA, Caetano dos Santos, FL, Cahill, LE, Cahuana-Hurtado, L, Cámera, LA, Campos-Nonato, IR, Cantu-Brito, C, Car, J, Carrero, JJ, Carvalho, F, Castañeda-Orjuela, CA, Catalá-López, F, Cerin, E, Charan, J, Chattu, VK, Chen, S, Chin, KL, Choi, J-YJ, Chu, D-T, Chung, S-C, Cirillo, M, Coffey, S, Conti, S, Costa, VM, Cundiff, DK, Dadras, O, Dagnew, B, Dai, X, Damasceno, AAM, Dandona, L, Dandona, R, Davletov, K, De la Cruz-Góngora, V, De la Hoz, FP, De Neve, J-W, Denova-Gutiérrez, E, Derbew Molla, M, Derseh, BT, Desai, R, Deuschl, G, Dharmaratne, SD, Dhimal, M, Dhungana, RR, Dianatinasab, M, Diaz, D, Djalalinia, S, Dokova, K, Douiri, A, Duncan, BB, Duraes, AR, Eagan, AW, Ebtehaj, S, Eftekhari, A, Eftekharzadeh, S, Ekholuenetale, M, El Nahas, N, Elgendy, IY, Elhadi, M, El-Jaafary, SI, Esteghamati, S, Etisso, AE, Eyawo, O, Fadhil, I, Faraon, EJA, Faris, PS, Farwati, M, Farzadfar, F, Fernandes, E, Fernandez Prendes, C, Ferrara, P, Filip, I, Fischer, F, Flood, D, Fukumoto, T, Gad, MM, Gaidhane, S, Ganji, M, Garg, J, Gebre, AK, Gebregiorgis, BG, Gebregzabiher, KZ, Gebremeskel, GG, Getacher, L, Obsa, AG, Ghajar, A, Ghashghaee, A, Ghith, N, Giampaoli, S, Gilani, SA, Gill, PS, Gillum, RF, Glushkova, EV, Gnedovskaya, EV, Golechha, M, Gonfa, KB, Goudarzian, AH, Goulart, AC, Guadamuz, JS, Guha, A, Guo, Y, Gupta, R, Hachinski, V, Hafezi-Nejad, N, Haile, TG, Hamadeh, RR, Hamidi, S, Hankey, GJ, Hargono, A, Hartono, RK, Hashemian, M, Hashi, A, Hassan, S, Hassen, HY, Havmoeller, RJ, Hay, SI, Hayat, K, Heidari, G, Herteliu, C, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Iavicoli, I, Ibeneme, CU, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Iqbal, U, Irvani, SSN, Shariful Islam, Sheikh, Islam, RM, Iso, H, Iwagami, M, Jain, V, Javaheri, T, Jayapal, SK, Jayaram, S, Jayawardena, R, Jeemon, P, Jha, RP, Jonas, JB, Jonnagaddala, J, Joukar, F, Jozwiak, JJ, Jürisson, M, Kabir, A, Kahlon, T, Kalani, R, Kalhor, R, Kamath, A, Kamel, I, Kandel, H, Kandel, A, Karch, A, Kasa, AS, Katoto, PDMC, Kayode, GA, Khader, YS, Khammarnia, M, Khan, MS, Khan, MN, Khan, M, Khan, EA, Khatab, K, Kibria, GMA, Kim, YJ, Kim, GR, Kimokoti, RW, Kisa, S, Kisa, A, Kivimäki, M, Kolte, D, Koolivand, A, Korshunov, VA, Koulmane Laxminarayana, SL, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Kuate Defo, B, Kucuk Bicer, B, Kulkarni, V, Kumar, GA, Kumar, N, Kurmi, OP, Kusuma, D, Kwan, GF, La Vecchia, C, Lacey, B, Lallukka, T, Lan, Q, Lasrado, S, Lassi, ZS, Lauriola, P, Lawrence, WR, Laxmaiah, A, LeGrand, KE, Li, M-C, Li, B, Li, S, Lim, SS, Lim, L-L, Lin, H, Lin, Z, Lin, R-T, Liu, X, Lopez, AD, Lorkowski, S, Lotufo, PA, Lugo, A, M, NK, Madotto, F, Mahmoudi, M, Majeed, A, Malekzadeh, R, Malik, AA, Mamun, AA, Manafi, N, Mansournia, MA, Mantovani, LG, Martini, S, Mathur, MR, Mazzaglia, G, Mehata, S, Mehndiratta, MM, Meier, T, Menezes, RG, Meretoja, A, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirrakhimov, EM, Mirzaei, H, Moazen, B, Moghadaszadeh, M, Mohammad, Y, Mohammad, DK, Mohammed, S, Mohammed, MA, Mokhayeri, Y, Molokhia, M, Montasir, AA, Moradi, G, Moradzadeh, R, Moraga, P, Morawska, L, Moreno Velásquez, I, Morze, J, Mubarik, S, Muruet, W, Musa, KI, Nagarajan, AJ, Nalini, M, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Nascimento, BR, Nayak, VC, Nazari, J, Nazarzadeh, M, Negoi, RI, Neupane Kandel, S, Nguyen, HLT, Nixon, MR, Norrving, B, Noubiap, JJ, Nouthe, BE, Nowak, C, Odukoya, OO, Ogbo, FA, Olagunju, AT, Orru, H, Ortiz, A, Ostroff, SM, Padubidri, JR, Palladino, R, Pana, A, Panda-Jonas, S, Parekh, U, Park, E-C, Parvizi, M, Pashazadeh Kan, F, Patel, UK, Pathak, M, Paudel, R, Pepito, VCF, Perianayagam, A, Perico, N, Pham, HQ, Pilgrim, T, Piradov, MA, Pishgar, F, Podder, V, Polibin, RV, Pourshams, A, Pribadi, DRA, Rabiee, N, Rabiee, M, Radfar, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Ur Rahman, MH, Rahman, Muhammad, Rahmani, AM, Rakovac, I, Ram, P, Ramalingam, S, Rana, J, Ranasinghe, P, Rao, SJ, Rathi, P, Rawal, L, Rawasia, WF, Rawassizadeh, R, Remuzzi, G, Renzaho, AMN, Rezapour, A, Riahi, SM, Roberts-Thomson, RL, Roever, L, Rohloff, P, Romoli, M, Roshandel, G, Rwegerera, GM, Saadatagah, S, Saber-Ayad, MM, Sabour, S, Sacco, S, Sadeghi, M, Saeedi Moghaddam, S, Safari, S, Sahebkar, A, Salehi, S, Salimzadeh, H, Samaei, M, Samy, AM, Santos, IS, Santric-Milicevic, MM, Sarrafzadegan, N, Sarveazad, A, Sathish, T, Sawhney, M, Saylan, M, Schmidt, MI, Schutte, AE, Senthilkumaran, S, Sepanlou, SG, Sha, F, Shahabi, S, Shahid, I, Shaikh, MA, Shamali, M, Shamsizadeh, M, Shawon, MSR, Sheikh, A, Shigematsu, M, Shin, M-J, Shin, JI, Shiri, R, Shiue, I, Shuval, K, Siabani, S, Siddiqi, TJ, Silva, DAS, Singh, JA, Mtech, AS, Skryabin, VY, Skryabina, AA, Soheili, A, Spurlock, EE, Stockfelt, L, Stortecky, S, Stranges, S, Suliankatchi Abdulkader, R, Tadbiri, H, Tadesse, EG, Tadesse, DB, Tajdini, M, Tariqujjaman, M, Teklehaimanot, BF, Temsah, M-H, Tesema, AK, Thakur, B, Thankappan, KR, Thapar, R, Thrift, AG, Timalsina, B, Tonelli, M, Touvier, M, Tovani-Palone, MR, Tripathi, A, Tripathy, JP, Truelsen, TC, Tsegay, GM, Tsegaye, GW, Tsilimparis, N, Tusa, BS, Tyrovolas, S, Umapathi, KK, Unim, B, Unnikrishnan, B, Usman, MS, Vaduganathan, M, Valdez, PR, Vasankari, TJ, Velazquez, DZ, Venketasubramanian, N, Vu, GT, Vujcic, IS, Waheed, Y, Wang, Y, Wang, F, Wei, J, Weintraub, RG, Weldemariam, AH, Westerman, R, Winkler, AS, Wiysonge, CS, Wolfe, CDA, Wubishet, BL, Xu, G, Yadollahpour, A, Yamagishi, K, Yan, LL, Yandrapalli, S, Yano, Y, Yatsuya, H, Yeheyis, TY, Yeshaw, Y, Yilgwan, CS, Yonemoto, N, Yu, C, Yusefzadeh, H, Zachariah, G, Zaman, SB, Zaman, MS, Zamanian, M, Zand, R, Zandifar, A, Zarghi, A, Zastrozhin, MS, Zastrozhina, A, Zhang, Z-J, Zhang, Y, Zhang, W, Zhong, C, Zou, Z, Zuniga, YMH, and Murray, CJL
Abstract: Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019.Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019.Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside hi
Published: 2020

20. The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Author: Sepanlou, SG, Safiri, S, Bisignano, C, Ikuta, KS, Merat, S, Saberifiroozi, M, Poustchi, H, Tsoi, D, Colombara, DV, Abdoli, A, Adedoyin, RA, Afarideh, M, Agrawal, S, Ahmad, S, Ahmadian, E, Ahmadpour, E, Akinyemiju, T, Akunna, CJ, Alipour, V, Almasi-Hashiani, A, Almulhim, AM, Al-Raddadi, RM, Alvis-Guzman, N, Anber, NH, Angus, C, Anoushiravani, A, Arabloo, J, Araya, EM, Asmelash, D, Ataeinia, B, Ataro, Z, Atout, MMW, Ausloos, F, Awasthi, A, Badawi, A, Banach, M, Bejarano Ramirez, DF, Bhagavathula, AS, Bhala, N, Bhattacharyya, K, Biondi, A, Bolla, SR, Boloor, A, Borzi, AM, Butt, ZA, Alberto Camera, LLA, Campos-Nonato, IR, Carvalho, F, Dinh-Toi, C, Chung, S-C, Cortesi, PA, Costa, VM, Cowie, BC, Daryani, A, de Courten, B, Demoz, GT, Desai, R, Dharmaratne, SD, Djalalinia, S, Hoa, TD, Dorostkar, F, Drake, TM, Dubey, M, Duncan, BB, Effiong, A, Eftekhari, A, Elsharkawy, A, Etemadi, A, Farahmand, M, Farzadfar, F, Fernandes, E, Filip, I, Fischer, F, Gebremedhin, KBB, Geta, B, Gilani, SA, Gill, PS, Alma Gutierrez, R, Haile, MT, Haj-Mirzaian, A, Hamid, SS, Hasankhani, M, Hasanzadeh, A, Hashemian, M, Hassen, HY, Hay, SI, Hayat, K, Heidari, B, Henok, A, Chi, LH, Hostiuc, M, Hostiuc, S, Hsieh, VC-R, Igumbor, EU, Ilesanmi, OS, Irvani, SSN, Balalami, NJ, James, SL, Jeemon, P, Jha, RP, Jonas, JB, Jozwiak, JJ, Kabir, A, Kasaeian, A, Kassaye, HG, Kefale, AT, Khan, RKMA, Khan, EA, Khater, A, Kim, YJ, Koyanagi, A, La Vecchia, C, Lim, L-L, Lopez, AD, Lorkowski, S, Lotufo, PA, Lozano, R, Abd El Razek, MM, Hue, TM, Manafi, N, Manafi, A, Mansournia, MA, Mantovani, LG, Mazzaglia, G, Mehta, D, Mendoza, W, Menezes, RG, Mengesha, MM, Meretoja, TJ, Mestrovic, T, Miazgowski, B, Miller, TR, Mirrakhimov, EM, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohammadian-Hafshejani, A, Mohammed, S, Mokdad, AH, Montero-Zamora, PA, Moradi, G, Naimzada, MD, Nayak, V, Negoi, I, Trang, HN, Ofori-Asenso, R, Oh, I-H, Olagunju, TO, Padubidri, JR, Pakshir, K, Pana, A, Pathak, M, Pourshams, A, Rabiee, N, Radfar, A, Rafiei, A, Ramezanzadeh, K, Rana, SMM, Rawaf, S, Rawaf, DL, Reiner, RC, Roever, L, Room, R, Roshandel, G, Safari, S, Samy, AM, Sanabria, J, Sartorius, B, Schmidt, MI, Senthilkumaran, S, Shaikh, MA, Sharif, M, Sharifi, A, Shigematsu, M, Singh, JA, Soheili, A, Suleria, HAR, Teklehaimanot, BF, Tesfay, BE, Vacante, M, Vahedian-Azimi, A, Valdez, PR, Vasankari, TJ, Giang, TV, Waheed, Y, Weldegwergs, KG, Werdecker, A, Westerman, R, Wondafrash, DZ, Wondmieneh, AB, Yeshitila, YG, Yonemoto, N, Yu, C, Zaidi, Z, Zarghi, A, Zelber-Sagi, S, Zewdie, KA, Zhang, Z-J, Zhao, X-J, Naghavi, M, Malekzadeh, R, Sepanlou, SG, Safiri, S, Bisignano, C, Ikuta, KS, Merat, S, Saberifiroozi, M, Poustchi, H, Tsoi, D, Colombara, DV, Abdoli, A, Adedoyin, RA, Afarideh, M, Agrawal, S, Ahmad, S, Ahmadian, E, Ahmadpour, E, Akinyemiju, T, Akunna, CJ, Alipour, V, Almasi-Hashiani, A, Almulhim, AM, Al-Raddadi, RM, Alvis-Guzman, N, Anber, NH, Angus, C, Anoushiravani, A, Arabloo, J, Araya, EM, Asmelash, D, Ataeinia, B, Ataro, Z, Atout, MMW, Ausloos, F, Awasthi, A, Badawi, A, Banach, M, Bejarano Ramirez, DF, Bhagavathula, AS, Bhala, N, Bhattacharyya, K, Biondi, A, Bolla, SR, Boloor, A, Borzi, AM, Butt, ZA, Alberto Camera, LLA, Campos-Nonato, IR, Carvalho, F, Dinh-Toi, C, Chung, S-C, Cortesi, PA, Costa, VM, Cowie, BC, Daryani, A, de Courten, B, Demoz, GT, Desai, R, Dharmaratne, SD, Djalalinia, S, Hoa, TD, Dorostkar, F, Drake, TM, Dubey, M, Duncan, BB, Effiong, A, Eftekhari, A, Elsharkawy, A, Etemadi, A, Farahmand, M, Farzadfar, F, Fernandes, E, Filip, I, Fischer, F, Gebremedhin, KBB, Geta, B, Gilani, SA, Gill, PS, Alma Gutierrez, R, Haile, MT, Haj-Mirzaian, A, Hamid, SS, Hasankhani, M, Hasanzadeh, A, Hashemian, M, Hassen, HY, Hay, SI, Hayat, K, Heidari, B, Henok, A, Chi, LH, Hostiuc, M, Hostiuc, S, Hsieh, VC-R, Igumbor, EU, Ilesanmi, OS, Irvani, SSN, Balalami, NJ, James, SL, Jeemon, P, Jha, RP, Jonas, JB, Jozwiak, JJ, Kabir, A, Kasaeian, A, Kassaye, HG, Kefale, AT, Khan, RKMA, Khan, EA, Khater, A, Kim, YJ, Koyanagi, A, La Vecchia, C, Lim, L-L, Lopez, AD, Lorkowski, S, Lotufo, PA, Lozano, R, Abd El Razek, MM, Hue, TM, Manafi, N, Manafi, A, Mansournia, MA, Mantovani, LG, Mazzaglia, G, Mehta, D, Mendoza, W, Menezes, RG, Mengesha, MM, Meretoja, TJ, Mestrovic, T, Miazgowski, B, Miller, TR, Mirrakhimov, EM, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohammadian-Hafshejani, A, Mohammed, S, Mokdad, AH, Montero-Zamora, PA, Moradi, G, Naimzada, MD, Nayak, V, Negoi, I, Trang, HN, Ofori-Asenso, R, Oh, I-H, Olagunju, TO, Padubidri, JR, Pakshir, K, Pana, A, Pathak, M, Pourshams, A, Rabiee, N, Radfar, A, Rafiei, A, Ramezanzadeh, K, Rana, SMM, Rawaf, S, Rawaf, DL, Reiner, RC, Roever, L, Room, R, Roshandel, G, Safari, S, Samy, AM, Sanabria, J, Sartorius, B, Schmidt, MI, Senthilkumaran, S, Shaikh, MA, Sharif, M, Sharifi, A, Shigematsu, M, Singh, JA, Soheili, A, Suleria, HAR, Teklehaimanot, BF, Tesfay, BE, Vacante, M, Vahedian-Azimi, A, Valdez, PR, Vasankari, TJ, Giang, TV, Waheed, Y, Weldegwergs, KG, Werdecker, A, Westerman, R, Wondafrash, DZ, Wondmieneh, AB, Yeshitila, YG, Yonemoto, N, Yu, C, Zaidi, Z, Zarghi, A, Zelber-Sagi, S, Zewdie, KA, Zhang, Z-J, Zhao, X-J, Naghavi, M, and Malekzadeh, R
Abstract: BACKGROUND: Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 on the burden of cirrhosis and its trends since 1990, by cause, sex, and age, for 195 countries and territories. METHODS: We used data from vital registrations, vital registration samples, and verbal autopsies to estimate mortality. We modelled prevalence of total, compensated, and decompensated cirrhosis on the basis of hospital and claims data. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost due to premature death and years lived with disability. Estimates are presented as numbers and age-standardised or age-specific rates per 100 000 population, with 95% uncertainty intervals (UIs). All estimates are presented for five causes of cirrhosis: hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis (NASH), and other causes. We compared mortality, prevalence, and DALY estimates with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries. FINDINGS: In 2017, cirrhosis caused more than 1·32 million (95% UI 1·27-1·45) deaths (440 000 [416 000-518 000; 33·3%] in females and 883 000 [838 000-967 000; 66·7%] in males) globally, compared with less than 899 000 (829 000-948 000) deaths in 1990. Deaths due to cirrhosis constituted 2·4% (2·3-2·6) of total deaths globally in 2017 compared with 1·9% (1·8-2·0) in 1990. Despite an increase in the number of deaths, the age-standardised death rate decreased from 21·0 (19·2-22·3) per 100 000 population in 1990 to 16·5 (15·8-18·1) per 100 000 population in 2017. Sub-Saharan Africa had the highest age-standardised death rate among GBD super-regions fo
Published: 2020

21. Epidemiology of injuries from fire, heat and hot substances: global, regional and national morbidity and mortality estimates from the Global Burden of Disease 2017 study

Author: James, SL, Lucchesi, LR, Bisignano, C, Castle, CD, Dingels, Z, Fox, JT, Hamilton, EB, Henry, NJ, McCracken, D, Roberts, NLS, Sylte, DO, Ahmadi, A, Ahmed, MB, Alahdab, F, Alipour, V, Andualem, Z, Antonio, CAT, Arabloo, J, Badiye, AD, Bagherzadeh, M, Banstola, A, Baernighausen, TW, Barzegar, A, Bayati, M, Bhaumik, S, Bijani, A, Bukhman, G, Carvalho, F, Crowe, CS, Dalal, K, Daryani, A, Nasab, MD, Hoa, TD, Huyen, PD, Endries, AY, Fernandes, E, Filip, I, Fischer, F, Fukumoto, T, Gebremedhin, KBB, Gebremeskel, GG, Gilani, SA, Haagsma, JA, Hamidi, S, Hostiuc, S, Househ, M, Igumbor, EU, Ilesanmi, OS, Irvani, SSN, Jayatilleke, AU, Kahsay, A, Kapoor, N, Kasaeian, A, Khader, YS, Khalil, IA, Khan, EA, Khazaee-Pool, M, Kokubo, Y, Lopez, AD, Madadin, M, Majdan, M, Maled, V, Malekzadeh, R, Manafi, N, Manafi, A, Mangalam, S, Massenburg, BB, Meles, HG, Menezes, RG, Meretoja, TJ, Miazgowski, B, Miller, TR, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Morrison, SD, Negoi, I, Trang, HN, Son, HN, Cuong, TN, Nixon, MR, Olagunju, AT, Olagunju, TO, Padubidri, JR, Polinder, S, Rabiee, N, Rabiee, M, Radfar, A, Rahimi-Movaghar, V, Rawaf, S, Rawaf, DL, Rezapour, A, Rickard, J, Roro, EM, Roy, N, Safari-Faramani, R, Salamati, P, Samy, AM, Satpathy, M, Sawhney, M, Schwebel, DC, Senthilkumaran, S, Sepanlou, SG, Shigematsu, M, Soheili, A, Stokes, MA, Tohidinik, HR, Bach, XT, Valdez, PR, Wijeratne, T, Yisma, E, Zaidi, Z, Zamani, M, Zhang, Z-J, Hay, S, Mokdad, AH, James, SL, Lucchesi, LR, Bisignano, C, Castle, CD, Dingels, Z, Fox, JT, Hamilton, EB, Henry, NJ, McCracken, D, Roberts, NLS, Sylte, DO, Ahmadi, A, Ahmed, MB, Alahdab, F, Alipour, V, Andualem, Z, Antonio, CAT, Arabloo, J, Badiye, AD, Bagherzadeh, M, Banstola, A, Baernighausen, TW, Barzegar, A, Bayati, M, Bhaumik, S, Bijani, A, Bukhman, G, Carvalho, F, Crowe, CS, Dalal, K, Daryani, A, Nasab, MD, Hoa, TD, Huyen, PD, Endries, AY, Fernandes, E, Filip, I, Fischer, F, Fukumoto, T, Gebremedhin, KBB, Gebremeskel, GG, Gilani, SA, Haagsma, JA, Hamidi, S, Hostiuc, S, Househ, M, Igumbor, EU, Ilesanmi, OS, Irvani, SSN, Jayatilleke, AU, Kahsay, A, Kapoor, N, Kasaeian, A, Khader, YS, Khalil, IA, Khan, EA, Khazaee-Pool, M, Kokubo, Y, Lopez, AD, Madadin, M, Majdan, M, Maled, V, Malekzadeh, R, Manafi, N, Manafi, A, Mangalam, S, Massenburg, BB, Meles, HG, Menezes, RG, Meretoja, TJ, Miazgowski, B, Miller, TR, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Morrison, SD, Negoi, I, Trang, HN, Son, HN, Cuong, TN, Nixon, MR, Olagunju, AT, Olagunju, TO, Padubidri, JR, Polinder, S, Rabiee, N, Rabiee, M, Radfar, A, Rahimi-Movaghar, V, Rawaf, S, Rawaf, DL, Rezapour, A, Rickard, J, Roro, EM, Roy, N, Safari-Faramani, R, Salamati, P, Samy, AM, Satpathy, M, Sawhney, M, Schwebel, DC, Senthilkumaran, S, Sepanlou, SG, Shigematsu, M, Soheili, A, Stokes, MA, Tohidinik, HR, Bach, XT, Valdez, PR, Wijeratne, T, Yisma, E, Zaidi, Z, Zamani, M, Zhang, Z-J, Hay, S, and Mokdad, AH
Abstract: BACKGROUND: Past research has shown how fires, heat and hot substances are important causes of health loss globally. Detailed estimates of the morbidity and mortality from these injuries could help drive preventative measures and improved access to care. METHODS: We used the Global Burden of Disease 2017 framework to produce three main results. First, we produced results on incidence, prevalence, years lived with disability, deaths, years of life lost and disability-adjusted life years from 1990 to 2017 for 195 countries and territories. Second, we analysed these results to measure mortality-to-incidence ratios by location. Third, we reported the measures above in terms of the cause of fire, heat and hot substances and the types of bodily injuries that result. RESULTS: Globally, there were 8 991 468 (7 481 218 to 10 740 897) new fire, heat and hot substance injuries in 2017 with 120 632 (101 630 to 129 383) deaths. At the global level, the age-standardised mortality caused by fire, heat and hot substances significantly declined from 1990 to 2017, but regionally there was variability in age-standardised incidence with some regions experiencing an increase (eg, Southern Latin America) and others experiencing a significant decrease (eg, High-income North America). CONCLUSIONS: The incidence and mortality of injuries that result from fire, heat and hot substances affect every region of the world but are most concentrated in middle and lower income areas. More resources should be invested in measuring these injuries as well as in improving infrastructure, advancing safety measures and ensuring access to care.
Published: 2020

22. Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study.

Author: James, SL, Castle, CD, Dingels, ZV, Fox, JT, Hamilton, EB, Liu, Z, Roberts, NLS, Sylte, DO, Bertolacci, GJ, Cunningham, M, Henry, NJ, Catalá-López, F, Cerin, E, Chandan, JS, Chapman, JR, Chattu, VK, Chattu, SK, Chatziralli, I, Chaudhary, N, Cho, DY, Choi, J-YJ, LeGrand, KE, Kabir Chowdhury, MA, Christopher, DJ, Chu, D-T, Cicuttini, FM, Coelho, JM, Costa, VM, Dahlawi, SMA, Daryani, A, Dávila-Cervantes, CA, Leo, DD, Abdelalim, A, Demeke, FM, Demoz, GT, Demsie, DG, Deribe, K, Desai, R, Nasab, MD, Silva, DDD, Dibaji Forooshani, ZS, Do, HT, Doyle, KE, Abdollahpour, I, Driscoll, TR, Dubljanin, E, Adema, BD, Eagan, AW, Elemineh, DA, El-Jaafary, SI, El-Khatib, Z, Ellingsen, CL, Zaki, MES, Eskandarieh, S, Abdulkader, RS, Eyawo, O, Faris, PS, Faro, A, Farzadfar, F, Fereshtehnejad, S-M, Fernandes, E, Ferrara, P, Fischer, F, Folayan, MO, Fomenkov, AA, Abedi, A, Foroutan, M, Francis, JM, Franklin, RC, Fukumoto, T, Geberemariyam, BS, Gebremariam, H, Gebremedhin, KB, Gebremeskel, LG, Gebremeskel, GG, Gebremichael, B, Abegaz, KH, Gedefaw, GA, Geta, B, Getenet, AB, Ghafourifard, M, Ghamari, F, Gheshlagh, RG, Gholamian, A, Gilani, SA, Gill, TK, Goudarzian, AH, Abosetugn, AE, Goulart, AC, Grada, A, Grivna, M, Guimarães, RA, Guo, Y, Gupta, G, Haagsma, JA, Hall, BJ, Hamadeh, RR, Hamidi, S, Abushouk, AI, Handiso, DW, Haro, JM, Hasanzadeh, A, Hassan, S, Hassanipour, S, Hassankhani, H, Hassen, HY, Havmoeller, R, Hendrie, D, Heydarpour, F, Adebayo, OM, Híjar, M, Ho, HC, Hoang, CL, Hole, MK, Holla, R, Hossain, N, Hosseinzadeh, M, Hostiuc, S, Hu, G, Ibitoye, SE, Adsuar, JC, Ilesanmi, OS, Inbaraj, LR, Naghibi Irvani, SS, Mofizul Islam, M, Shariful Islam, SM, Ivers, RQ, Jahani, MA, Jakovljevic, M, Jalilian, F, Jayaraman, S, Advani, SM, Jayatilleke, AU, Jha, RP, John-Akinola, YO, Jonas, JB, Jones, KM, Joseph, N, Joukar, F, Jozwiak, JJ, Jungari, SB, Jürisson, M, Agudelo-Botero, M, Kabir, A, Kahsay, A, Kalankesh, LR, Kalhor, R, Kamil, TA, Kanchan, T, Kapoor, N, Karami, M, Kasaeian, A, Kassaye, HG, Ahmad, T, Kavetskyy, T, Kayode, GA, Keiyoro, PN, Kelbore, AG, Khader, YS, Khafaie, MA, Khalid, N, Khalil, IA, Khalilov, R, Khan, M, Ahmed, MB, Khan, EA, Khan, J, Khanna, T, Khazaei, S, Khazaie, H, Khundkar, R, Kiirithio, DN, Kim, Y-E, Kim, YJ, Kim, D, Ahmed, R, Kisa, S, Kisa, A, Komaki, H, Kondlahalli, SKM, Koolivand, A, Korshunov, VA, Koyanagi, A, Kraemer, MUG, Krishan, K, Defo, BK, Eddine Aichour, MT, Bicer, BK, Kugbey, N, Kumar, N, Kumar, M, Kumar, V, Kumaresh, G, Lami, FH, Lansingh, VC, Lasrado, S, Alahdab, F, Latifi, A, Lauriola, P, Vecchia, CL, Leasher, JL, Huey Lee, SW, Li, S, Liu, X, Lopez, AD, Lotufo, PA, Lyons, RA, Alanezi, FM, Machado, DB, Madadin, M, Abd El Razek, MM, Mahotra, NB, Majdan, M, Majeed, A, Maled, V, Malta, DC, Manafi, N, Manafi, A, Alema, NM, Manda, A-L, Manjunatha, N, Mansour-Ghanaei, F, Mansournia, MA, Maravilla, JC, Mason-Jones, AJ, Masoumi, SZ, Massenburg, BB, Maulik, PK, Mehndiratta, MM, Alemu, BW, Melketsedik, ZA, Memiah, PTN, Mendoza, W, Menezes, RG, Mengesha, MM, Meretoja, TJ, Meretoja, A, Merie, HE, Mestrovic, T, Miazgowski, B, Alghnam, SA, Miazgowski, T, Miller, TR, Mini, GK, Mirica, A, Mirrakhimov, EM, Mirzaei-Alavijeh, M, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohamadi, E, Ali, BA, Mohammad, Y, Darwesh, AM, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, S, Mohammed, JA, Mohebi, F, Mohseni Bandpei, MA, Molokhia, M, Monasta, L, Ali, S, Moodley, Y, Moradi, M, Moradi, G, Moradi-Lakeh, M, Moradzadeh, R, Morawska, L, Velásquez, IM, Morrison, SD, Mossie, TB, Muluneh, AG, Alinia, C, Musa, KI, Mustafa, G, Naderi, M, Nagarajan, AJ, Naik, G, Naimzada, MD, Najafi, F, Nangia, V, Nascimento, BR, Naserbakht, M, Alipour, V, Nayak, V, Nazari, J, Ndwandwe, DE, Negoi, I, Ngunjiri, JW, Nguyen, TH, Nguyen, CT, Nguyen, DN, Thi Nguyen, HL, Nikbakhsh, R, Aljunid, SM, Anggraini Ningrum, DN, Nnaji, CA, Ofori-Asenso, R, Ogbo, FA, Oghenetega, OB, Oh, I-H, Olagunju, AT, Olagunju, TO, Bali, AO, Onwujekwe, OE, Almasi-Hashiani, A, Orpana, HM, Ota, E, Otstavnov, N, Otstavnov, SS, P A, M, Padubidri, JR, Pakhale, S, Pakshir, K, Panda-Jonas, S, Park, E-K, Almasri, NA, Patel, SK, Pathak, A, Pati, S, Paulos, K, Peden, AE, Filipino Pepito, VC, Pereira, J, Phillips, MR, Polibin, RV, Polinder, S, Altirkawi, K, Pourmalek, F, Pourshams, A, Poustchi, H, Prakash, S, Angga Pribadi, DR, Puri, P, Syed, ZQ, Rabiee, N, Rabiee, M, Radfar, A, Abdeldayem Amer, YS, Rafay, A, Rafiee, A, Rafiei, A, Rahim, F, Rahimi, S, Rahman, MA, Rajabpour-Sanati, A, Rajati, F, Rakovac, I, Rao, SJ, Andrei, CL, Rashedi, V, Rastogi, P, Rathi, P, Rawaf, S, Rawal, L, Rawassizadeh, R, Renjith, V, Resnikoff, S, Rezapour, A, Ribeiro, AI, Ansari-Moghaddam, A, Rickard, J, Rios González, CM, Roever, L, Ronfani, L, Roshandel, G, Saddik, B, Safarpour, H, Safdarian, M, Mohammad Sajadi, S, Salamati, P, T Antonio, CA, Rashad Salem, MR, Salem, H, Salz, I, Samy, AM, Sanabria, J, Riera, LS, Santric Milicevic, MM, Sarker, AR, Sarveazad, A, Sathian, B, Anvari, D, Sawhney, M, Sayyah, M, Schwebel, DC, Seedat, S, Senthilkumaran, S, Seyedmousavi, S, Sha, F, Shaahmadi, F, Shahabi, S, Shaikh, MA, Yaw Appiah, SC, Shams-Beyranvand, M, Sheikh, A, Shigematsu, M, Shin, JI, Shiri, R, Siabani, S, Sigfusdottir, ID, Singh, JA, Singh, PK, Sinha, DN, Arabloo, J, Soheili, A, Soriano, JB, Sorrie, MB, Soyiri, IN, Stokes, MA, Sufiyan, MB, Sykes, BL, Tabarés-Seisdedos, R, Tabb, KM, Taddele, BW, Arab-Zozani, M, Tefera, YM, Tehrani-Banihashemi, A, Tekulu, GH, Tesema Tesema, AK, Tesfay, BE, Thapar, R, Titova, MV, Tlaye, KG, Tohidinik, HR, Topor-Madry, R, Arefi, Z, Tran, KB, Tran, BX, Tripathy, JP, Tsai, AC, Tsatsakis, A, Car, LT, Ullah, I, Ullah, S, Unnikrishnan, B, Upadhyay, E, Aremu, O, Uthman, OA, Valdez, PR, Vasankari, TJ, Veisani, Y, Venketasubramanian, N, Violante, FS, Vlassov, V, Waheed, Y, Wang, Y-P, Wiangkham, T, Ariani, F, Wolde, HF, Woldeyes, DH, Wondmeneh, TG, Wondmieneh, AB, Wu, A-M, Wyper, GMA, Yadav, R, Yadollahpour, A, Yano, Y, Yaya, S, 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Abegaz, KH, Gedefaw, GA, Geta, B, Getenet, AB, Ghafourifard, M, Ghamari, F, Gheshlagh, RG, Gholamian, A, Gilani, SA, Gill, TK, Goudarzian, AH, Abosetugn, AE, Goulart, AC, Grada, A, Grivna, M, Guimarães, RA, Guo, Y, Gupta, G, Haagsma, JA, Hall, BJ, Hamadeh, RR, Hamidi, S, Abushouk, AI, Handiso, DW, Haro, JM, Hasanzadeh, A, Hassan, S, Hassanipour, S, Hassankhani, H, Hassen, HY, Havmoeller, R, Hendrie, D, Heydarpour, F, Adebayo, OM, Híjar, M, Ho, HC, Hoang, CL, Hole, MK, Holla, R, Hossain, N, Hosseinzadeh, M, Hostiuc, S, Hu, G, Ibitoye, SE, Adsuar, JC, Ilesanmi, OS, Inbaraj, LR, Naghibi Irvani, SS, Mofizul Islam, M, Shariful Islam, SM, Ivers, RQ, Jahani, MA, Jakovljevic, M, Jalilian, F, Jayaraman, S, Advani, SM, Jayatilleke, AU, Jha, RP, John-Akinola, YO, Jonas, JB, Jones, KM, Joseph, N, Joukar, F, Jozwiak, JJ, Jungari, SB, Jürisson, M, Agudelo-Botero, M, Kabir, A, Kahsay, A, Kalankesh, LR, Kalhor, R, Kamil, TA, Kanchan, T, Kapoor, N, Karami, M, Kasaeian, A, Kassaye, HG, Ahmad, T, Kavetskyy, T, Kayode, GA, Keiyoro, PN, Kelbore, AG, Khader, YS, Khafaie, MA, Khalid, N, Khalil, IA, Khalilov, R, Khan, M, Ahmed, MB, Khan, EA, Khan, J, Khanna, T, Khazaei, S, Khazaie, H, Khundkar, R, Kiirithio, DN, Kim, Y-E, Kim, YJ, Kim, D, Ahmed, R, Kisa, S, Kisa, A, Komaki, H, Kondlahalli, SKM, Koolivand, A, Korshunov, VA, Koyanagi, A, Kraemer, MUG, Krishan, K, Defo, BK, Eddine Aichour, MT, Bicer, BK, Kugbey, N, Kumar, N, Kumar, M, Kumar, V, Kumaresh, G, Lami, FH, Lansingh, VC, Lasrado, S, Alahdab, F, Latifi, A, Lauriola, P, Vecchia, CL, Leasher, JL, Huey Lee, SW, Li, S, Liu, X, Lopez, AD, Lotufo, PA, Lyons, RA, Alanezi, FM, Machado, DB, Madadin, M, Abd El Razek, MM, Mahotra, NB, Majdan, M, Majeed, A, Maled, V, Malta, DC, Manafi, N, Manafi, A, Alema, NM, Manda, A-L, Manjunatha, N, Mansour-Ghanaei, F, Mansournia, MA, Maravilla, JC, Mason-Jones, AJ, Masoumi, SZ, Massenburg, BB, Maulik, PK, Mehndiratta, MM, Alemu, BW, Melketsedik, ZA, Memiah, PTN, Mendoza, W, Menezes, RG, Mengesha, MM, Meretoja, TJ, Meretoja, A, Merie, HE, Mestrovic, T, Miazgowski, B, Alghnam, SA, Miazgowski, T, Miller, TR, Mini, GK, Mirica, A, Mirrakhimov, EM, Mirzaei-Alavijeh, M, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohamadi, E, Ali, BA, Mohammad, Y, Darwesh, AM, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, S, Mohammed, JA, Mohebi, F, Mohseni Bandpei, MA, Molokhia, M, Monasta, L, Ali, S, Moodley, Y, Moradi, M, Moradi, G, Moradi-Lakeh, M, Moradzadeh, R, Morawska, L, Velásquez, IM, Morrison, SD, Mossie, TB, Muluneh, AG, Alinia, C, Musa, KI, Mustafa, G, Naderi, M, Nagarajan, AJ, Naik, G, Naimzada, MD, Najafi, F, Nangia, V, Nascimento, BR, Naserbakht, M, Alipour, V, Nayak, V, Nazari, J, Ndwandwe, DE, Negoi, I, Ngunjiri, JW, Nguyen, TH, Nguyen, CT, Nguyen, DN, Thi Nguyen, HL, Nikbakhsh, R, Aljunid, SM, Anggraini Ningrum, DN, Nnaji, CA, Ofori-Asenso, R, Ogbo, FA, Oghenetega, OB, Oh, I-H, Olagunju, AT, Olagunju, TO, Bali, AO, Onwujekwe, OE, Almasi-Hashiani, A, Orpana, HM, Ota, E, Otstavnov, N, Otstavnov, SS, P A, M, Padubidri, JR, Pakhale, S, Pakshir, K, Panda-Jonas, S, Park, E-K, Almasri, NA, Patel, SK, Pathak, A, Pati, S, Paulos, K, Peden, AE, Filipino Pepito, VC, Pereira, J, Phillips, MR, Polibin, RV, Polinder, S, Altirkawi, K, Pourmalek, F, Pourshams, A, Poustchi, H, Prakash, S, Angga Pribadi, DR, Puri, P, Syed, ZQ, Rabiee, N, Rabiee, M, Radfar, A, Abdeldayem Amer, YS, Rafay, A, Rafiee, A, Rafiei, A, Rahim, F, Rahimi, S, Rahman, MA, Rajabpour-Sanati, A, Rajati, F, Rakovac, I, Rao, SJ, Andrei, CL, Rashedi, V, Rastogi, P, Rathi, P, Rawaf, S, Rawal, L, Rawassizadeh, R, Renjith, V, Resnikoff, S, Rezapour, A, Ribeiro, AI, Ansari-Moghaddam, A, Rickard, J, Rios González, CM, Roever, L, Ronfani, L, Roshandel, G, Saddik, B, Safarpour, H, Safdarian, M, Mohammad Sajadi, S, Salamati, P, T Antonio, CA, Rashad Salem, MR, Salem, H, Salz, I, Samy, AM, Sanabria, J, Riera, LS, Santric Milicevic, MM, Sarker, AR, Sarveazad, A, Sathian, B, Anvari, D, Sawhney, M, Sayyah, M, Schwebel, DC, Seedat, S, Senthilkumaran, S, Seyedmousavi, S, Sha, F, Shaahmadi, F, Shahabi, S, Shaikh, MA, Yaw Appiah, SC, Shams-Beyranvand, M, Sheikh, A, Shigematsu, M, Shin, JI, Shiri, R, Siabani, S, Sigfusdottir, ID, Singh, JA, Singh, PK, Sinha, DN, Arabloo, J, Soheili, A, Soriano, JB, Sorrie, MB, Soyiri, IN, Stokes, MA, Sufiyan, MB, Sykes, BL, Tabarés-Seisdedos, R, Tabb, KM, Taddele, BW, Arab-Zozani, M, Tefera, YM, Tehrani-Banihashemi, A, Tekulu, GH, Tesema Tesema, AK, Tesfay, BE, Thapar, R, Titova, MV, Tlaye, KG, Tohidinik, HR, Topor-Madry, R, Arefi, Z, Tran, KB, Tran, BX, Tripathy, JP, Tsai, AC, Tsatsakis, A, Car, LT, Ullah, I, Ullah, S, Unnikrishnan, B, Upadhyay, E, Aremu, O, Uthman, OA, Valdez, PR, Vasankari, TJ, Veisani, Y, Venketasubramanian, N, Violante, FS, Vlassov, V, Waheed, Y, Wang, Y-P, Wiangkham, T, Ariani, F, Wolde, HF, Woldeyes, DH, Wondmeneh, TG, Wondmieneh, AB, Wu, A-M, Wyper, GMA, Yadav, R, Yadollahpour, A, Yano, Y, Yaya, S, Arora, A, Yazdi-Feyzabadi, V, Ye, P, Yip, P, Yisma, E, Yonemoto, N, Yoon, S-J, Youm, Y, Younis, MZ, Yousefi, Z, Yu, C, Asaad, M, Yu, Y, Moghadam, TZ, Zaidi, Z, Zaman, SB, Zamani, M, Zandian, H, Zarei, F, Zhang, Z-J, Zhang, Y, Ziapour, A, Ayala Quintanilla, BP, Zodpey, S, Dandona, R, Dharmaratne, SD, Hay, SI, Mokdad, AH, Pigott, DM, Reiner, RC, Vos, T, Ayano, G, Ayanore, MA, Azarian, G, Badawi, A, Badiye, AD, Baig, AA, Bairwa, M, Bakhtiari, A, Balachandran, A, Banach, M, Banerjee, SK, Banik, PC, Banstola, A, Barker-Collo, SL, Bärnighausen, TW, Barzegar, A, Bayati, M, Bazargan-Hejazi, S, Bedi, N, Behzadifar, M, Belete, H, Bennett, DA, Bensenor, IM, Berhe, K, Bhagavathula, AS, Bhardwaj, P, Bhat, AG, Bhattacharyya, K, Bhutta, ZA, Bibi, S, Bijani, A, Boloor, A, Borges, G, Borschmann, R, Borzì, AM, Boufous, S, Braithwaite, D, Briko, NI, Brugha, T, Budhathoki, SS, Car, J, Cárdenas, R, Carvalho, F, Castaldelli-Maia, JM, Castañeda-Orjuela, CA, and Castelpietra, G
Abstract: BACKGROUND: While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. METHODS: In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced. RESULTS: GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes. CONCLUSIONS: GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future.
Published: 2020

23. Effect of naringin co-administration on oral bioavailability of efavirenz in Rabbit

Author: Asif, Mohammad, Patel, Rakesh K., Patel, Hardik, and Gilani, Sadaf Jamal
Published: 2022
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24. A molecular phylogeny of selected species of Genus Prunus L. (Rosaceae) from Pakistan using the TRN-L & TRN-F spacer DNA

Author: Gilani, SA, Qureshi, RA, Khan, M, Ullah, F, Nawaz, Z, Ahmad, I, and Potter, D
Subjects: Prunus, chloroplast, TRN-L, TRN-F, Pakistan
Abstract: The genus Prunus L. is an important plant for fruit production and it includes plums, apricots, cherries, almonds and peaches that are sources of food for the local people. The family Rosaceae is not yet published in Flora of Pakistan and there is a lot of taxonomic work that is yet to be done for the proper classification and placement of different genera under different sub-families. Prunus is found in almost all the four provinces of Pakistan including Punjab, Khyber Pakhtunkhwa (former NWFP), Sindh and Baluchistan which includes Azad Kashmir region. In the present study, the genus Prunus was studied in detail to find out the phylogenetic relationship among the 12 species of Prunus selected from different regions of Pakistan and GenBank using the maximum parsimony analysis of sequence polymorphism in chloroplast TRN-L and TRN-F spacer DNA. The results for the TRN-L and TRN-F primers confirm the work done by early phylogenetists including Potter and Bortiri with additions to new species from Pakistan including Prunus dulcis (Mill.) D.A. Webb. (Syn. Prunus amygdalus) and Prunus cornuta (Wall. ex. Royle) Steudel. which are indigenous to Pakistan.Key Words: Prunus, chloroplast, TRN-L, TRN-F, Pakistan.
Published: 2013

25. A molecular phylogeny of selected species of genus Prunus L. (Rosaceae) from Pakistan using the internal transcribed spacer (ITS) spacer DNA

Author: Gilani, SA, Qureshi, RA, Khan, AM, and Potter, D
Subjects: Phylogeny, Prunus, Pakistan, molecular phylogeny, nuclear primers
Abstract: Prunus is found in all four provinces of Pakistan, that is, Punjab, NWFP, Sindh and Baluchistan including Azad Kashmir region. Studies on the family Rosaceae is scanty in the Flora of Pakistan and there is a lot of taxonomic work yet to be done, for the proper classification and placement of different genera under different sub-families. In the present study, the genus Prunus was studied in detail to find out the phylogenetic relationship among the 23 species of Prunus, selected from different regions of Pakistan and GenBank using maximum parsimony analysis of sequence polymorphism in nuclear ITS-9 and ITS-6 spacer DNA. The results for the internal transcribed spacer (ITS)- 9 and ITS- 6 primers confirm the work done by early phylogenetists with additions of new species from Pakistan including Prunus bokhariensis, Prunus dulcis (Mill.) D.A. Webb. (Syn. Prunus amygdalus) and Prunus cornuta (Wall. ex. Royle) Steudel. These are indigenous to Pakistan. In the ITS strict consensus results for example, the clade consisting of Laurocerasus, Padus and Cerasus subgenera are sister to the rest of the clades in the phylogenetic tree.Key words: Phylogeny, Prunus, Pakistan, molecular phylogeny, nuclear primers.
Published: 2013

26. Optimization and Validation for Simultaneous Estimation of Citicoline and Piracetam in bulk and tablet formulations using RP-HPLC method: Analytical quality by design approach

Author: Mittal, Ashu, Parmar, Shikha, Gilani, Sadaf Jamal, Imam, Syed Sarim, and Taleuzzaman, Mohamad
Published: 2017
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27. Phytochemical, pharmacological and ethnobotanical studies in mango ginger (Curcuma amada Roxb.; Zingiberaceae)

Author: Jatoi SA, Kikuchi A, Gilani SA, and Watanabe KN
Abstract: Curcuma amada Roxb. is an important species known as mango ginger due to its characteristic raw-mango aroma. It has a long history of traditional uses ranging from folk medicine to several culinary preparations. The phytochemical, pharmacological and ethnobotanical studies of C. amada are reviewed. The rhizome is rich in essential oils, and more than 130 chemical constituents with biomedical significance have been isolated from it. Its antibacterial, insecticidal, antifungal and antioxidant properties have been investigated. The conservation of indigenous knowledge by proper documentation is suggested. The chemotaxonomy, allelopathy and genetic diversity of C. amada have not yet been explored, and many such studies are possible. This review was compiled to provide consolidated information covering different aspects of the plant, to provide a basis on which to plan future studies and to promote sustainable use of C. amada. Copyright (c) 2007 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Published: 2007
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28. Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Author: Abbafati, C., Machado, D.B., Cislaghi, B., Salman, O.M., Karanikolos, M., McKee, M., Abbas, K.M., Brady, O.J., Larson, H.J., Trias-Llimós, S., Cummins, S., Langan, S.M., Sartorius, B., Hafiz, A., Jenabi, E., Mohammad Gholi Mezerji, N., Borzouei, S., Azarian, G., Khazaei, S., Abbasi, M., Asghari, B., Masoumi, S., Komaki, H., Taherkhani, A., Adabi, M., Abbasifard, M., Bazmandegan, G., Kamiab, Z., Vakilian, A., Anjomshoa, M., Mokari, A., Sabour, S., Shahbaz, M., Saeedi, R., Ahmadieh, H., Yousefinezhadi, T., Haj-Mirzaian, A., Nikbakhsh, R., Safi, S., Asgari, S., Irvani, S.N., Jahanmehr, N., Ramezanzadeh, K., Abbasi-Kangevari, M., Khayamzadeh, M., Abbastabar, H., Shirkoohi, R., Fazlzadeh, M., Janjani, H., Hosseini, M., Mansournia, M., Tohidinik, H., Bakhtiari, A., Fazaeli, A., Mousavi, S., Hasanzadeh, A., Nabavizadeh, B., Malekzadeh, R., Hashemian, M., Pourshams, A., Salimzadeh, H., Sepanlou, S.G., Afarideh, M., Esteghamati, A., Esteghamati, S., Ghajar, A., Heidari, B., Rezaei, N., Mohamadi, E., Rahimi-Movaghar, A., Rahim, F., Eskandarieh, S., Sahraian, M., Mohebi, F., Aminorroaya, A., Ebrahimi, H., Farzadfar, F., Mohajer, B., Pishgar, F., Saeedi Moghaddam, S., Shabani, M., Zarafshan, H., Abolhassani, H., Hafezi-Nejad, N., Heidari-Soureshjani, R., Abdollahi, M., Farahmand, M., Salamati, P., Mehrabi Nasab, E., Tajdini, M., Aghamir, S., Mirzaei, R., Dibaji Forooshani, Z., Khater, M.M., Abd-Allah, F., Abdelalim, A., Abualhasan, A., El-Jaafary, S.I., Hassan, A., Elsharkawy, A., Khater, A.M., Elhabashy, H.R., Salem, M.R.R., Salem, H., Sadeghi, M., Jafarinia, M., Amini-Rarani, M., Mohammadifard, N., Sarrafzadegan, N., Abdollahpour, I., Sarveazad, A., Tehrani-Banihashemi, A., Yoosefi Lebni, J., Manafi, N., Pazoki Toroudi, H., Dorostkar, F., Alipour, V., Sheikhtaheri, A., Arabloo, J., Azari, S., Ghashghaee, A., Rezapour, A., Naserbakht, M., Kabir, A., Mehri, F., Yousefifard, M., Asadi-Aliabadi, M., Babaee, E., Eshrati, B., Goharinezhad, S., Moradi-Lakeh, M., Abedi, P., 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Pigott, D.M., Reiner Jr, R.C., Roth, G.A., Stanaway, J.D., Vollset, S., Vos, T., Wang, H., Lim, S.S., Murray, C.J.L., Kalani, R., Ikuta, K.S., Cho, D.Y., Kneib, C.J., Crowe, C.S., Massenburg, B.B., Morrison, S.D., Acebedo, A., Adelson, J.D., Agesa, K.M., Alam, T., Albertson, S.B., Anderson, J.A., Antony, C.M., Ashbaugh, C., Assmus, M., Azhar, G., Balassyano, S., Bannick, M.S., Barthelemy, C.M., Bender, R.G., Bennitt, F.B., Bertolacci, G.J., Biehl, M.H., Bisignano, C., Boon-Dooley, A.S., Briant, P.S., Bryazka, D., Bumgarner, B.R., Callender, C.S., Cao, J., Castle, C.D., Castro, E., Causey, K., Cercy, K.M., Chalek, J., Charlson, F.J., Cohen, A.J., Comfort, H., Compton, K., Croneberger, A.J., Cruz, J.A., Cunningham, M., Dandona, R., Dangel, W.J., Dean, F.E., DeCleene, N.K., Deen, A., Degenhardt, L., Dingels, Z.V., Dippenaar, I.N., Dirac, M.A., Dolgert, A.J., Emmons-Bell, S., Estep, K., Farag, T., Feigin, V.L., Feldman, R., Ferrara, G., Ferrari, A.J., Fitzgerald, R., Force, L.M., Fox, 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Maria, Borzouei, Shiva, Brady, Oliver J, Braithwaite, Dejana, Brauer, Michael, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Bumgarner, Blair R, Burugina Nagaraja, Sharath, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cai, Tianji, Callender, Charlton SKH, Cámera, Luis LA Alberto, Campos-Nonato, Ismael R, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-Maia, Joao Mauricio, Castelpietra, Giulio, Castro, Franz, Catalá-López, Ferrán, Cederroth, Christopher R, Cerin, Ester, Chattu, Vijay Kumar, Chin, Ken Lee, Chu, Dinh-Toi, Ciobanu, Liliana G, Cirillo, Massimo, Comfort, Haley, Costa, Vera Marisa, Cowden, Richard G, Cromwell, Elizabeth A, Croneberger, Andrew J, Cunningham, Matthew, Dahlawi, Saad M A, Damiani, Giovanni, D'Amico, Emanuele, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Darwesh, Aso Mohammad, Daryani, Ahmad, Das Gupta, Rajat, das Neves, José, Davletov, Kairat, De Leo, Diego, Denova-Gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolao, Desai, Rupak, Dhungana, Govinda Prasad, Dias da Silva, Diana, Diaz, Daniel, Dippenaar, Ilse N, Djalalinia, Shirin, Do, Hoa Thi, Dokova, Klara, Doku, David Teye, Dorostkar, Fariba, Doshi, Chirag P, Doshmangir, Leila, Doyle, Kerrie E, Dubljanin, Eleonora, Duraes, Andre Rodrigue, Edvardsson, David, Effiong, Andem, El Sayed, Iman, El Tantawi, Maha, Elbarazi, Iffat, El-Jaafary, Shaimaa I, Emamian, Mohammad Hassan, Eskandarieh, Sharareh, Esmaeilzadeh, Firooz, Estep, Kara, Farahmand, Mohammad, Faraj, Anwar, Fareed, Mohammad, Faridnia, Roghiyeh, Faro, Andre, Farzadfar, Farshad, Fattahi, Nazir, Fazaeli, Ali Akbar, Fazlzadeh, Mehdi, Feigin, Valery L, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Ferreira, Manuela L, Filip, Irina, Fischer, Florian, Flohr, Carsten, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Freitas, Marisa, Fukumoto, Takeshi, Fuller, John E, Furtado, João M, Gad, Mohamed M, Gakidou, Emmanuela, Gallus, Silvano, Gebrehiwot, Abiyu Mekonnen, Gebremedhin, Ketema Bizuwork, Gething, Peter W, Ghamari, Farhad, Ghashghaee, Ahmad, Gholamian, Asadollah, Gilani, Syed Amir, Gitimoghaddam, Mojgan, Glushkova, Ekaterina Vladimirovna, Gnedovskaya, Elena V, Gopalani, Sameer Vali, Goulart, Alessandra C, Gugnani, Harish Chander, Guo, Yuming, Gupta, Rajeev, Gupta, Subodh Sharan, Haagsma, Juanita A, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Halvaei, Iman, Hamadeh, Randah R, Hamagharib Abdullah, Kanaan, Han, Chieh, Handiso, Demelash Woldeyohanne, Hankey, Graeme J, Haririan, Hamidreza, Haro, Josep Maria, Hasaballah, Ahmed I, Hassanipour, Soheil, Hassankhani, Hadi, Hay, Simon I, Heibati, Behzad, Heidari-Soureshjani, Reza, Henny, Kiana, Henry, Nathaniel J, Herteliu, Claudiu, Heydarpour, Fatemeh, Hole, Michael K, Hoogar, Praveen, Hosgood, H Dean, Hossain, Naznin, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hoy, Damian G, Hu, Guoqing, Huda, Tanvir M, Ibitoye, Segun Emmanuel, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Imani-Nasab, Mohammad Hasan, Islam, Mdmohaimenul, Iso, Hiroyasu, Iwu, Chinwe Juliana, Jaafari, Jalil, Jacobsen, Kathryn H, Jahagirdar, Deepa, Jahanmehr, Nader, Jalali, Amir, Jalilian, Farzad, James, Spencer L, Janjani, Hosna, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S, Jonas, Jost B, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Zubair, Kalani, Hamed, Kalankesh, Leila R, Kamiab, Zahra, Kanchan, Tanuj, Kapoor, Neeti, Karch, André, Karimi, Salah Eddin, Karimi, Seyed Asaad, Kassebaum, Nicholas J, Katikireddi, Srinivasa Vittal, Kawakami, Norito, Kayode, Gbenga A, Keiyoro, Peter Njenga, Keller, Cathleen, Khader, Yousef Saleh, Khalid, Nauman, Khan, Ejaz Ahmad, Khan, Maseer, Khang, Young-Ho, Khater, Amir M, Khater, Mona M, Khazaei, Salman, Khazaie, Habibolah, Khodayari, Mohammad Taghi, Khubchandani, Jagdish, Kianipour, Neda, Kim, Cho-il, Kim, Young-Eun, Kim, Yun Jin, Kinfu, Yohanne, Kisa, Adnan, Kisa, Sezer, Kissimova-Skarbek, Katarzyna, Kivimäki, Mika, Komaki, Hamidreza, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael A, Krishan, Kewal, Krohn, Kris J, Kuate Defo, Barthelemy, Kumar, G Anil, Kumar, Manasi, Kumar, Pushpendra, Kumar, Vivek, Kusuma, Dian, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lami, Faris Hasan, Lansky, Sonia, Larson, Samantha Leigh, Larsson, Anders O, Lasrado, Savita, Lassi, Zohra S, Lazarus, Jeffrey V, Lee, Paul H, Lee, Shaun Wen Huey, Leever, Andrew T, Legrand, Kate E, Leonardi, Matilde, Li, Shanshan, Lim, Lee-Ling, Lim, Stephen S, Linn, Shai, Lodha, Rakesh, Logroscino, Giancarlo, Lopez, Alan D, Lopukhov, Platon D, Lotufo, Paulo A, Lozano, Rafael, Lu, Alton, Lunevicius, Raimunda, Madadin, Mohammed, Maddison, Emilie R, Magdy Abd El Razek, Hassan, Magdy Abd El Razek, Muhammed, Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Malekzadeh, Reza, Mamun, Abdullah A, Manafi, Navid, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Mastrogiacomo, Claudia I, Mathur, Manu Raj, May, Erin A, Mcalinden, Colm, Mcgrath, John J, Mckee, Martin, Mehndiratta, Man Mohan, Mehri, Fereshteh, Mehta, Kala M, Meitei, Wahengbam Bigyananda, Memiah, Peter T N, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Mensah, George A, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Michalek, Irmina Maria, Mihretie, Kebadnew Mulatu, Miller, Ted R, Mills, Edward J, Milne, George J, Mirrakhimov, Erkin M, Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke Temesgen, Moazen, Babak, Moghadaszadeh, Masoud, Mohamadi, Efat, Mohammad, Dara K, Mohammad, Yousef, Mohammad Gholi Mezerji, Naser, Mohammadbeigi, Abolfazl, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Hussen, Mohammed, Shafiu, Mohebi, Farnam, Mohseni Bandpei, Mohammad A, Mokari, Amin, Mokdad, Ali H, Momen, Natalie C, Monasta, Lorenzo, Mooney, Meghan D, Moradi, Ghobad, Moradi, Masoud, Moradi-Joo, Mohammad, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Moreno Velásquez, Ilai, Morgado-da-Costa, Joana, Morrison, Shane Dougla, Mosser, Jonathan F, Mouodi, Simin, Mousavi, Seyyed Meysam, Mousavi Khaneghah, Amin, Mueller, Ulrich Otto, Musa, Kamarul Imran, Muthupandian, Saravanan, Nabavizadeh, Behnam, Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Ndwandwe, Duduzile Edith, Negoi, Ionut, Negoi, Ruxandra Irina, Ngunjiri, Josephine W, Nguyen, Huong Lan Thi, Nguyen, Trang Huyen, Nigatu, Yeshambel T, Nikbakhsh, Rajan, Nikpoor, Amin Reza, Nixon, Molly R, Nnaji, Chukwudi A, Nomura, Shuhei, Noubiap, Jean Jacque, Nouraei Motlagh, Soraya, Nowak, Christoph, Oţoiu, Adrian, Odell, Christopher M, Oh, In-Hwan, Oladnabi, Morteza, Olagunju, Andrew T, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Omar Bali, Ahmed, Ong, Kanyin L, Onwujekwe, Obinna E, Ortiz, Alberto, Otstavnov, Nikita, Otstavnov, Stanislav S, Øverland, Simon, Owolabi, Mayowa O, P A, Mahesh, Padubidri, Jagadish Rao, Pakshir, Keyvan, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Park, Jame, Pasupula, Deepak Kumar, Patel, Jenil R, Patel, Sangram Kishor, Patton, George C, Paulson, Katherine R, Pazoki Toroudi, Hamidreza, Pease, Spencer A, Peden, Amy E, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K, Pereira, Alexandre, Pereira, David M, Perico, Norberto, Pigott, David M, Pilgrim, Thoma, Pilz, Tessa M, Piradov, Michael A, Pirsaheb, Meghdad, Pokhrel, Khem Narayan, Postma, Maarten J, Pourjafar, Hadi, Pourmalek, Farshad, Pourshams, Akram, Poznańska, Anna, Prada, Sergio I, Prakash, Sanjay, Preotescu, Liliana, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Raggi, Alberto, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Ram, Pradhum, Ranabhat, Chhabi Lal, Rao, Sowmya J, Rasella, Davide, Rashedi, Vahid, Rastogi, Prateek, Rathi, Priya, Rawal, Lal, Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M N, Resnikoff, Serge, Rezaei, Nima, Rezai, Mohammad sadegh, Rezapour, Aziz, Rickard, Jennifer, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Rostamian, Morteza, Rubagotti, Enrico, Rwegerera, Godfrey M, Sabour, Siamak, Saddik, Basema, Sadeghi, Ehsan, Sadeghi, Masoumeh, Saeedi Moghaddam, Sahar, Safari, Yahya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S Mohammad, Salahshoor, Mohammad Reza, Salama, Joseph S, Salamati, Payman, Salem, Marwa R Rashad, Salimi, Yahya, Salomon, Joshua A, Salz, Inbal, Samad, Zainab, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M, Saraswathy, Sivan Yegnanarayana Iyer, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Saylan, Mete, Schaeffer, Lauren E, Schiavolin, Silvia, Schwebel, David C, Schwendicke, Falk, Sekerija, Mario, Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serván-Mori, Edson, Shabani, Mahsima, Shahabi, Saeed, Shahbaz, Mohammad, Shaheen, Amira A, Shaikh, Masood Ali, Shalash, Ali S, Shams-Beyranvand, Mehran, Shamsi, Mohammadbagher, Shamsizadeh, Morteza, Shannawaz, Mohammed, Sharafi, Kiomar, Sharafi, Zeinab, Sharara, Fablina, Sharma, Rajesh, Shaw, David H, Sheikh, Aziz, Shin, Jae Il, Shiri, Rahman, Shrime, Mark G, Shuval, Kerem, Siabani, Soraya, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, Diego Augusto Santo, Simonetti, Biagio, Simpson, Kyle E, Singh, Jasvinder A, Skiadaresi, Eirini, Skryabin, Valentin Yurievich, Soheili, Amin, Sokhan, Anton, Sorensen, Reed J D, Soriano, Joan B, Sorrie, Muluken Bekele, Soyiri, Ireneous N, Spurlock, Emma Elizabeth, Sreeramareddy, Chandrashekhar T, Stockfelt, Leo, Stokes, Mark A, Stubbs, Jacob L, Sudaryanto, Agu, Sufiyan, Mu'awiyyah Babale, Suliankatchi Abdulkader, Rizwan, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tabb, Karen M, Tadakamadla, Santosh Kumar, Taherkhani, Amir, Tang, Muming, Taveira, Nuno, Taylor, Heather Jean, Teagle, Whitney L, Tehrani-Banihashemi, Arash, Teklehaimanot, Berhane Fseha, Tessema, Zemenu Tadesse, Thankappan, Kavumpurathu Raman, Thomas, Nihal, Thrift, Amanda G, Titova, Mariya Vladimirovna, Tohidinik, Hamid Reza, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Foti, Tovani-Palone, Marcos Roberto Roberto, Traini, Eugenio, Tran, Bach Xuan, Travillian, Ravensara, Trias-Llimós, Sergi, Truelsen, Thomas Clement, Tudor Car, Lorainne, Unnikrishnan, Bhaskaran, Upadhyay, Era, Vacante, Marco, Vakilian, Alireza, Valdez, Pascual R, Valli, Alessandro, Vardavas, Constantine, Vasankari, Tommi Juhani, Vasconcelos, Ana Maria Nogale, Vasseghian, Yasser, Veisani, Yousef, Venketasubramanian, Narayanaswamy, Vidale, Simone, Violante, Francesco S, Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Vujcic, Isidora S, Vukovic, Ana, Vukovic, Rade, Waheed, Yasir, Wallin, Mitchell Taylor, Walters, Magdalene K, Wang, Hongbo, Wang, Yuan-Pang, Watson, Stefanie, Wei, Jingkai, Weiss, Jordan, Weldesamuel, Girmay Teklay, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Wiangkham, Taweewat, Wiens, Kirsten E, Wijeratne, Tissa, Wiysonge, Charles Shey, Wojtyniak, Bogdan, Wolfe, Charles D A, Wondmieneh, Adam Belay, Wool, Eve E, Wu, Ai-Min, Wu, Junjie, Xu, Gelin, Yamada, Tomohide, Yamagishi, Kazumasa, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yearwood, Jamal A, Yeheyis, Tomas Y, Yilgwan, Christopher Sabo, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Yoosefi Lebni, Javad, York, Hunter W, Younis, Mustafa Z, Younker, Theodore Patrick, Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Yousuf, Abdilahi Yousuf, Yusefzadeh, Hasan, Zahirian Moghadam, Telma, Zakzuk, Josefina, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zhang, Zhi-Jiang, Zheng, Peng, Zhou, Maigeng, Ziapour, Arash, Murray, Christopher J L, Collaborators, GBD 2019 Demographics, GBD 2019 Demographics Collaborator, Violante FS, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Department of Earth Systems Analysis, Biomechanical Engineering, TechMed Centre, Biomolecular Nanotechnology, Research Methodology, Measurement and Data Analysis, Materials Science and Technology of Polymers, Inorganic Materials Science, MESA+ Institute, Biomedical and Environmental Sensorsystems, Mesoscale Chemical Systems, Faculty of Engineering Technology, Nonlinear Solid Mechanics, Digital Society Institute, Pervasive Systems, Nanobiophysics, Faculty of Geo-Information Science and Earth Observation, Multi Scale Mechanics, Engineering Fluid Dynamics, Physics of Complex Fluids, Developmental BioEngineering, Physics of Fluids, Elastomer Technology and Engineering, Medical Cell Biophysics, European Membrane Institute, Department of Earth Observation Science, Biomaterials Science and Technology, Sustainable Process Technology, Department of Urban and Regional Planning and Geo-Information Management, Department of Natural Resources, XUV Optics, Databases (Former), Department of Water Resources, Psychology, Health & Technology, Membrane Science & Technology, Department of Public Health, Clinicum, HUS Neurocenter, HUS Comprehensive Cancer Center, and Environmental Sciences
Subjects: Male, very elderly, Demographic transition, HALE, 030204 cardiovascular system & hematology, preschool child, Global Burden of Disease, Carga Global de Enfermedades, 0302 clinical medicine, newborn, Risk Factors, Surveys and Questionnaires, and Risk Factors Study, 80 and over, 030212 general & internal medicine, Birth Rate, Child, Migration, 11 Medical and Health Sciences, Aged, 80 and over, education.field_of_study, Injuries, Geography, Mortality rate, 1. No poverty, DEATH, Censuses, General Medicine, SDG 10 - Reduced Inequalities, Middle Aged, Demographic analysis, 3142 Public health care science, environmental and occupational health, 3. Good health, demographic analysis, Estilo de Vida Saludable, risk factor, Child, Preschool, Demography/statistics & numerical data, Global Burden of Diseases, Injuries, Risk Factors, Fertility, Mortality, Migration, Population, epidemiology, Female, A990 Medicine and Dentistry not elsewhere classified, CHILD-MORTALITY, Live Birth, Global Health Metrics, TRANSITION, demographics, GBD, fertility, mortality, hale, Adult, Adolescent, Total fertility rate, Population, Global Burden of Diseases, Injuries, and Risk Factors Study, Birth rate, 03 medical and health sciences, Young Adult, Life Expectancy, SDG 3 - Good Health and Well-being, General & Internal Medicine, SYSTEMATIC ANALYSIS, Demografía, Humans, Global Burden of Disease Study, human, Mortality, education, Preschool, Aged, Demography, Spatial Analysis, questionnaire, Infant, Newborn, Klinisk medicin, HIV, Infant, Global Burden of Diseases, sex-specific fertility, Live Birth/epidemiology, purl.org/pe-repo/ocde/ford#3.02.00 [https], MODEL, Fertilidad, Fertility, Demographic change, Life expectancy, NA, global disease burden, Clinical Medicine, population research
Abstract: Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10-14 and 50-54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings The global TFR decreased from 2.72 (95% uncertainty interval [UI] 2.66-2.79) in 2000 to 2.31 (2.17-2.46) in 2019. Global annual livebirths increased from 134.5 million (131.5-137.8) in 2000 to a peak of 139.6 million (133.0-146.9) in 2016. Global livebirths then declined to 135.3 million (127.2-144.1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2.1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27.1% (95% UI 26.4-27.8) of global livebirths. Global life expectancy at birth increased from 67.2 years (95% UI 66.8-67.6) in 2000 to 73.5 years (72.8-74.3) in 2019. The total number of deaths increased from 50.7 million (49.5-51.9) in 2000 to 56.5 million (53.7-59.2) in 2019. Under-5 deaths declined from 9.6 million (9.1-10.3) in 2000 to 5.0 million (4.3-6.0) in 2019. Global population increased by 25.7%, from 6.2 billion (6.0-6.3) in 2000 to 7.7 billion (7.5-8.0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58.6 years (56.1-60.8) in 2000 to 63.5 years (60.8-66.1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.
Published: 2020

29. The effects of lumbar stabilization exercises with and without jaw movements in non-specific low back pain (A randomized controlled trial).

Author: Khan M, Zafar H, Gilani SA, Farooqui WA, and Ahmad A
Abstract: Objective: This study aimed to investigate the added effect of jaw clenching on the efficacy of lumbar stabilization exercises to manage chronic non-specific low back pain., Methods: This randomized controlled trial was conducted at the Sindh Institute of Physical Medicine and Rehabilitation (SIPM&R) Karachi from April 2021 to April 2023. Eighty patients with chronic non-specific low back pain participated in this study. Forty patients each were randomly allocated to the lumbar stability exercise (LSE) group' and the lumbar stability exercise with teeth clenching (LSETC) group. Patients in both groups performed respective exercises twice weekly for 12 weeks. The Numeric Pain Rating Scale (NPRS), Roland Morris Disability Questionnaire (RMDQ), and Pressure Biofeedback Unit (PBU) were used to assess pain, disability, and muscle endurance respectively. Data were collected at the baseline, after six weeks and 12 weeks of intervention. A p-value of <0.05 was considered statistically significant., Results: Both groups showed statistically significant improvements in pain, disability, and muscle endurance. Upon further stratification, participants aged 20-30 years in the LSETC group showed significantly higher scores than the LSE group for NPRS, RMDQ, and PBU after 12 weeks. Overall, the LSETC group showed relatively higher improvement in mean scores for NPRS, RMDQ, and PBU than the LSE group., Conclusion: Lumbar stabilization exercises with and without jaw movement are effective for the treatment of chronic non-specific low back pain. The addition of teeth clenching enhanced the effectiveness of lumbar stability exercises, especially in young adults. Trial Registration: Clinicaltrials.gov (NCT04801212), Prospectively registered on March 16, 2021., Competing Interests: Conflict of interest: None., (Copyright: © Pakistan Journal of Medical Sciences.)
Published: 2024
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30. Retraction Note: Effectiveness of ultrasound guided dry needling in management of jumper's knee: a randomized controlled trial.

Author: Sharif F, Ahmad A, and Gilani SA
Published: 2024
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31. Translation, cross-cultural adaptation and psychometric properties of the Urdu version of the back pain functional scale in low back pain patients.

Author: Afzal MW, Ahmad A, Gilani SA, Zulfaqar N, Fatima S, and Mahmmod T
Subjects: Humans, Male, Female, Adult, Middle Aged, Reproducibility of Results, Young Adult, Cross-Cultural Comparison, Adolescent, Disability Evaluation, Surveys and Questionnaires standards, Low Back Pain physiopathology, Psychometrics standards, Pain Measurement, Translations
Abstract: Background: Translation and validation of important scales in other languages reduce bias in reporting the functional status of the patient., Objective: To translate the Back Pain Functional Scale into Urdu (BPFSu), adapt it for use in other cultures, and evaluate its psychometric properties., Method: According to Beaton guidelines, translation and cultural adaption was carried out. On 100 Urdu-literate men and women aged 18-60 years with lower back pain, the final BPFSu was assessed for psychometric qualities. First at baseline and again after 7 days, participants completed the BPFSu, the Functional Rating Index (FRI), and the Numeric Pain Rating Scale (NPRS)., Results: Internal consistency of the BPFSu was excellent (Cronbach's alpha: 0.937). No floor and ceiling effects were found Excellent test-retest reliability (ICC = 0.882, CI 95%; 0.830-0.919) was achieved. Spearman correlation coefficient showed criterion validity with the NPRS (rho =â⁢⁢0.701, p⩽ 0.001) and Pearson correlation coefficient showed construct validity with the FRI (r=â⁢⁢0.740, p⩽ 0.001). The minimum detectable changes were 9.96, while the standard error of measurement was 3.6., Conclusion: The BPFSu is a valid and reliable instrument for assessing physical function in individuals experiencing low back discomfort.
Published: 2024
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32. Effects of Virtual Reality Exercises on Chronic Low Back Pain: Quasi-Experimental Study.

Author: Afzal MW, Ahmad A, Hanif HMB, Chaudhary N, and Gilani SA
Abstract: Background: Low back pain is a common health problem globally. Based on the duration of pain, it is classified as acute, subacute, or chronic low back pain. Different treatment strategies are available to reduce chronic low back pain. Virtual reality (VR) is a novel approach in back pain rehabilitation., Objective: This study aimed to compare the effects of VR games on chronic low back pain., Methods: This quasi-experimental study was conducted among 40 patients with chronic low back pain. The data were collected using a nonprobability, convenient sampling technique. Patients visiting the Department of Physiotherapy, Government Services Hospital, Lahore, Pakistan, were recruited and equally divided into 4 groups. Group A received the Reflex Ridge game; group B received the Body Ball game; group C combined the 2 games without back-strengthening exercises; and group D combined the 2 games with back-strengthening exercises. The participants received 8 treatment sessions, with 3 sessions/wk. The outcomes were pre- and posttest measurements of pain intensity, low back disability, and lumbar range of motion. The repeated measurement ANOVA was used for inter- and intragroup comparison, with significance at P≤.05., Results: The study comprised a sample of 40 patients with low back pain; 12 (40%) were female and 28 (60%) were male, with a mean age of 37.85 (SD 12.15) years. The pre- and posttest mean pain scores were 7.60 (SD 1.84) and 4.20 (SD 1.62) in group A, 6.60 (SD 1.776) and 5.90 (SD 1.73) in group B, 6.90 (SD 1.73) and 5.40 (SD 1.07) in group C, and 7.10 (SD 1.53) and 3.60 (SD 0.97) in group D, respectively. The mean pain score differences of group D (combining the Reflex Ridge and Body Ball games with back-strengthening exercises) compared to groups A, B, and C were -.60 (P=.76), -2.30 (P<.001), and -1.80 (P=.03), respectively. Regarding the range of motion, the forward lumbar flexion mean differences of group D compared to groups A, B, and C were 3.80 (P=.21), 4.80 (P=.07), and 7.40 (P<.001), respectively. Similarly, the right lateral lumbar flexion mean differences of group D compared to groups A, B, and C were 2.80 (P=.04), 5.20 (P<.001), and 4.80 (P<.001), respectively. The left lateral lumbar flexion mean differences of group D compared to groups A, B, and C were 2.80 (P<.001), 4.80 (P=.02), and 2.20 (P<.001). respectively, showing significant pre- and posttreatment effects., Conclusions: VR exercises had statistically significant effects on improving pain, low back disability, and range of motion in all groups, but the combination of Reflex Ridge and Body Ball games with back-strengthening exercises had dominant effects compared to the other groups., Trial Registration: Iranian Registry of Clinical Trial IRCT20200330046895N1; https://en.irct.ir/trial/46916., (©M Waqar Afzal, Ashfaq Ahmad, Hafiz Muhammad Bilal Hanif, Nauman Chaudhary, Syed Amir Gilani. Originally published in JMIR Rehabilitation and Assistive Technology (https://rehab.jmir.org), 15.09.2023.)
Published: 2023
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33. Intrarater and interrater reliability of the dynamic gait index in post stroke patients with eye movement disorders.

Author: Batool S, Zafar H, Gilani SA, Ahmad A, and Hanif A
Subjects: Humans, Aged, Reproducibility of Results, Postural Balance, Gait, Stroke complications, Ocular Motility Disorders
Abstract: Background: The Dynamic Gait Index (DGI) is a useful tool that has been evaluated for its reliability in patients with vestibular disorders, elderly people and, in chronic stroke population. Present study was aimed to evaluate the intrarater and interrater reliability of the DGI to measure dynamic balance and gait performance in stroke patients with eye movement disorders., Methods: A sample of 30 stroke patients suffering from eye movement disorders were recruited. Two Physical therapists assessed the intrarater and interrater reliability of the DGI in two testing sessions three days apart. In the later session, two raters assessed the patients' performance simultaneously on the DGI. The reliability was calculated using the intra-class correlation coefficient (ICC2, 1). Standard error of measurement (SEM) and minimal detectable change (MDC 95 ) at 95% confidence interval were also calculated. A significance level was set at p-value <0.05., Results: The (ICC2, 1) for intrarater and interrater reliability of total DGI scores was 0.86 and 0.91 respectively. While (ICC2, 1) for intrarater and interrater reliability of individual items ranged from 0.73 to 0.91 to 0.73-0.93, respectively. The (SEM) and (MDC 95 ) for intrarater reliability of total DGI scores were 0.76 and 2.10, respectively. Corresponding values for interrater reliability were 0.62 and 1.71, respectively., Conclusions: The DGI is a reliable tool for evaluating the dynamic balance and gait performance in stroke patients with eye movement disorders. This tool showed good to excellent intrarater and interrater reliability of total DGI scores and moderate to good intrarater and interrater reliability of individual items of the DGI., Competing Interests: Declaration of competing interest None., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
Published: 2023
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34. Effectiveness of ultrasound guided dry needling in management of jumper's knee: a randomized controlled trial.

Author: Sharif F, Ahmad A, and Gilani SA
Subjects: Humans, Ultrasonography, Ultrasonography, Interventional, Dry Needling, Tendinopathy diagnostic imaging, Tendinopathy therapy, Patellar Ligament diagnostic imaging
Abstract: Jumper's knee is highly prevalent condition in athletes. Very limited evidence is available on clinical effects of tendon dry needling. Therefore, the objective of this study is to compare the effects of ultrasound-guided dry needling (UG-DN) combined with conventional physical therapy and conventional physical therapy alone in patients with jumper's knee. A total of 96 patients with pre-diagnosed jumper's knee were randomly assigned to experimental group (UG-DN + CPT) and conventional group (CPT alone) with 48 participants each. Pain intensity and functional disability were recorded using visual Analogue Scale (VAS), Victorian Institute of Sports Assessment-Patellar Tendinopathy (VISA-P) questionnaire, Lysholm Scale, Knee Injury and Osteoarthritis Outcome Score (KOOS) respectively at baseline, at 1st, 2nd, and 4th week. Whereas ultrasonographic features of patellar tendon were measured through musculoskeletal ultrasound (MSKUS) at baseline and 4th week. Total 8 sessions of treatment were provided. Mann Whitney U test and Friedman test were used to compute between and within group differences respectively. P value was significant at 0.05. Results showed that patients in both groups had improvement in signs of jumper's knee but the improvement in UG-DN + CPT group was more significant (p ≤ 0.05). Significant difference was seen after 4 weeks of intervention in UG-DN + CPT group in VAS (Median ± I.Q.R = 3 ± 1, p = 0.000), VISA-P (Median ± I.Q.R = 83.5 ± 7, p = 0.000), KOOS (Median ± I.Q.R = 83.5 ± 8, p = 0.000), , Lysholm (Median ± I.Q.R = 84 ± 5, p = 0.000) than CPT group VAS (Median ± I.Q.R = 1.5 ± 1, p = 0.000), VISA-P (Median ± I.Q.R = 92 ± 2, p = 0.000), KOOS (Median ± I.Q.R = 92 ± 3, p = 0.000), Lysholm (Median ± I.Q.R = 92 ± 4, p = 0.000) and ultrasonographic features of jumper's knee were more significant in experimental group(p-value ≤ 0.05). The Ultrasound guided dry needling with conventional physical therapy of patellar tendon had been found an effective treatment for jumper's knee and helps in reducing pain intensity, improving function and ultrasonographic features in patients with jumper's knee. UG-DN + CPT group showed more significant results as compared to CPT.Trial registration: (IRCT20210409050913N1). Dated: 17.04.2021., (© 2023. The Author(s).)
Published: 2023
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35. Substantiating the predictive role of ultrasound imaging in athletes with lower limb tendinopathy: a systematic review.

Author: Sharif F, Ahmad A, Gilani SA, Bacha R, and Hanif A
Subjects: Humans, Prospective Studies, Ultrasonography, Athletes, Lower Extremity diagnostic imaging, Achilles Tendon diagnostic imaging, Tendinopathy diagnostic imaging
Abstract: Objective: To explore the potential of ultrasound imaging to anticipate and monitor future symptoms of patellar or Achilles' tendinopathy., Methods: The systematic review comprised prospective studies that used ultrasound imaging of Achilles' OR patellar tendons in asymptomatic patients at baseline and measurements of pain and/or function at follow-up. The Critical Appraisal Skills Programme checklist used to assess study quality and it was done by two independent reviewers., Results: Of the 19 studies reviewed, 9(47.3%) investigated patellar tendon alone, 6(31.5%) did both patellar and Achilles' tendon, and 4(21.2%) did Achilles tendon alone. The method of ultrasound administration was almost uniform for both the tendons. The studies showed that the use of ultrasound to predict lower limb tendinopathy was indefinite, but that a higher proportion of tendon disorganisation increased the risk of developing tendinopathy. In addition, promising results were obtained for the use of ultrasound in both Achilles' and patellar tendinopathy in monitoring the effect of load or treatment on tendon structure., Conclusions: The included studies had participants from different sports. Tendon irregularities at baseline on ultrasound were related to increased risk and future occurrence of both patellar and Achilles' tendinopathy. .
Published: 2023
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36. Effect of physical therapy treatment in infants treated for congenital muscular torticollis - a narrative review.

Author: Bashir A, Amjad F, Ahmad A, Arooj A, and Gilani SA
Subjects: Infant, Newborn, Infant, Humans, Neck Muscles, Physical Therapy Modalities, Torticollis therapy, Torticollis congenital, Muscular Diseases, Fibroma
Abstract: Congenital muscular torticollis is a problem that arises at birth or immediately after birth in which the sternocleidomastoid muscle is shortened on the afflicted side, leading to an ipsilateral rotated of the head and a contralateral rotation of the face and jaw. To determine the effectiveness of physical therapy treatment in infants treated for congenital muscular torticollis, relevant articles published between 2011 and 2020 were located using electronic databases. A total of 9 studies out of 24 potentially relevant articles were reviewed. All studies were randomised controlled trials with 6-8 score on the Physiotherapy Evidence Database scale (Pedro scale) which showed high quality of methodology. The studies typically found significant statistical effects in the management of congenital muscular torticollis. Additionally, most of the studies reported increased adherence to exercise as another essential advantage. Conservative physical therapy management showed positive outcomes, and early physiotherapy referral showed significant reduction in treatment duration.
Published: 2023
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37. Efficacy of ultrasound guided dry needling as an adjunct to conventional physical therapy for patients with jumper's knee: A randomized controlled trial.

Author: Sharif F, Ahmad A, Gilani SA, Bacha R, Hanif A, and Arif MA
Abstract: Background: Jumper's knee is a degenerative condition among athletes, and it has been treated with conventional physical therapy (CPT). Ultrasound guided dry needling (USG-DN) is a relatively new technique to explore clinical outcomes in patients with tendinopathy., Methods: This parallel group, single-blinded randomized controlled trial was carried out involving 94 athletes with clinically diagnosed jumper's knee, divided into an intervention group (USG-DN + CPT, n = 47) and a control group (CPT, n = 47). Participants received a 4-week programme; the intervention group received ultrasound guided patellar tendon dry needling (DN) in conjunction with CPT. The control group received only CPT. The visual analog scale (VAS), Victorian institute of sports assessment-Patellar tendinopathy (VISA-P) questionnaire, Lysholm scale, Knee injury and osteoarthritis outcome score (KOOS) and ultrasonographic features of patellar tendinopathy were evaluated at baseline,1 week, 2 weeks, and 4 weeks. The data were analyzed through SPSS-26., Results: The study found statistically significant differences ( P < 0.05) regarding VAS, Lysholm, VISA-P, and KOOS scales at baseline, 1st, 2nd, and 4th week post-intervention. Within-group differences also showed statistically significant results after the intervention. There were significant results observed in ultrasonographic outcomes between both groups at 1 month post-intervention (all P < 0.05)., Conclusion: The results of the current study suggest, ultrasound guided DN of patellar tendon in combination with CPT reduced pain, improved function, and showed a tendency to decrease tendon thickness in patients with patellar tendinopathy., Clinical Trial Registration Number: (IRCT20210409050913N1). Dated: 17.04.2021. https://www.irct.ir/user/trial/55607/view., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2022 Sharif, Ahmad, Gilani, Bacha, Hanif and Arif.)
Published: 2022
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38. Translation, cross-cultural adaptation, and psychometric properties of the Urdu version of Rand Short Form 36-item survey (SF-36) among patients with lumbar radiculopathy.

Author: Amjad F, Mohseni-Bandpei MA, Gilani SA, Ahmad A, and Zaheer A
Subjects: Cross-Cultural Comparison, Cross-Sectional Studies, Disability Evaluation, Humans, Language, Psychometrics, Quality of Life, Reproducibility of Results, Surveys and Questionnaires, Low Back Pain, Radiculopathy
Abstract: Background and Aims: Although Rand Short Form 36-item (SF-36) questionnaire is a frequently used tool for evaluating a patient's quality of life in both clinical and research settings, but its translation into Urdu language and its psychometric properties has not been tested before, in accordance to the pre-established guidelines. This study aimed to translate and assess the psychometric properties of Urdu version of SF-36 (SF-36-U) in lumbar radiculopathy patients., Methods: In this cross-sectional study, one hundred and eight patients of lumbar radiculopathy filled SF-36-U questionnaire, Urdu version of Oswestry Disability Index (ODI-U) and visual analogue scales for pain (VAS pain) at baseline and after 7 days. Two types of reliability i.e. internal consistency and test-retest reliability while three types of validity i.e. face, content, and construct validity were evaluated. Psychometric properties were assessed contrary to the a priori hypothesis and alpha level was kept at < 0.05., Results: SF-36-U presented good to excellent test-retest reliability for all eight domains (ICC 2,1 = 0.75-0.92). Internal consistency was also acceptable for all domains (Cronbach's alpha = 0.73-0.90). Face and content validity were found to be good. Pearson correlation revealed moderate to strong correlations of SF-36-U domains with ODI-U (r = 0.43-0.54), VAS pain (r = 0.32-0.49) and each of its own question (r = 0.37-0.88) which shows good construct validity., Conclusion: SF-36-U revealed acceptable psychometric properties and is considered as a reliable and valid questionnaire for assessing the health-related quality of life in Urdu-speaking patients having lumbar radiculopathy., Competing Interests: Declaration of competing interest None., (Copyright © 2022. Published by Elsevier Ltd.)
Published: 2022
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39. Reliability of dual inclinometer for lumbar range of motion using two different Landmarking techniques.

Author: Ahmed I, Mohseni Bandpei MA, Gilani SA, Ahmad A, and Zaidi F
Subjects: Male, Female, Humans, Adolescent, Young Adult, Adult, Reproducibility of Results, Observer Variation, Range of Motion, Articular, Lumbosacral Region, Low Back Pain diagnosis
Abstract: Objective: To measure the intra-rater and inter-rater reliability of active lumbar extension and flexion movements using dual inclinometer with two different landmarking techniques., Methods: The reliability study was conducted at the Physical Therapy Department of the University Teaching Hospital, The University of Lahore, Pakistan, in January 2020, and comprised patients of either gender aged >18 years with mild or symptomatic lower back pain, and healthy subjects s controls. Repeated measurements with dual inclinometer were taken by two examiners and data was recorded by two separate observers. A set of three active lumbar extension and flexion movements were performed for an initial warm-up. The examiners repeated a palpation of bony landmarks prior to each trial. The two different landmarking techniques were applied on the lumbar spine to identify the start and end points. Both the examiners measured each participant thrice. For each examiner and each landmarking technique, the three data sets were acquired for active lumbar extension and flexion for a total of 120 sets per session per examiner per landmarking. Each set comprised three alternating active lumbar extension and flexion movements. Data was analysed using SPSS version 26., Results: Of the 40 subjects with mean age 27.8+11.0 years, 19(48%) were males and 21(52%) were females. There were 15(38%) cases; 6(40%) males and 9(60%) females. The remaining 25(62%) were controls. The two landmarking techniques with dual inclinometer produced a high to very high intra-rater reliability (intraclass correlation coefficient:0.73-0.91) for both lumbar extension and flexion movements with moderate to low standard error of measurement values (0.36-1.31), while a high inter-rater reliability (intraclass correlation coefficient: 0.72-0.76; standard error of measurement: 0.52-0.63) for extension measurements and only moderate inter-rater reliability (intraclass correlation coefficient: 0.59-0.65; standard error of measurement: 1.36-1.49) for flexion measurements., Conclusion: Dual inclinometer along with skilled examiners and accurate landmarking methodology provided clinically reliable measurements.
Published: 2022
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40. Reliability of modified-modified Schober's test for the assessment of lumbar range of motion.

Author: Amjad F, Mohseni Bandpei MA, Gilani SA, and Arooj A
Subjects: Humans, Male, Female, Adult, Middle Aged, Reproducibility of Results, Range of Motion, Articular, Lumbosacral Region, Lumbar Vertebrae, Radiculopathy
Abstract: Objective: To determine the intra-rater reliability of modified-modified Schober's test for measuring lumbar flexion and extension in patients of lumbar radiculopathy., Methods: The case-control reliability study was conducted at the University of Lahore Teaching Hospital, Lahore, Pakistan, from March to September 2020, and comprised lumbar radiculopathy patients of either gender aged 35-60 years in group A and healthy controls in group B. Lumbar flexion and extension were measured by the same examiner on three different occasions. A non-stretching measuring tape was used in which the first two measurements were taken using the modified-modified Schober's test on the same day with a difference of 5 minutes, and the third measurement was taken three days later to assess reliability. To assess the test-retest reliability, intraclass correlation coefficient was calculated through two-way random analysis of variance. Standard error of measurement and minimal detectable change were also calculated. Data was analysed using SPSS 25., Results: Of the 40 subjects, 20(50%) were in group A with a mean age of 45.00±6.72 years, and 20(50%) were in group B with a mean age of 49.60±6.65 years. Overall, there were 16(40%) male and 24(60%) female subjects. Within-day lumbar flexion and extension measurements were highly reliable in controls (intraclass correlation coefficient 0.93 for flexion and 0.96 for extension) as well as in patients (intraclass correlation coefficient 0.94 for flexion and 0.95 for extension). The high values of intraclass correlation coefficient 0.91 for flexion and 0.94 for extension in the controls and 0.83 for flexion and 0.92 for extension in the patients showed high reliability also for between-days measurements., Conclusions: The modified-modified Schober's test appeared to be a highly reliable technique for the measurement of lumbar flexion and extension in patients of lumbar radiculopathy as well as in healthy controls.
Published: 2022
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41. Coronary-Pulmonary Artery Fistula Repair With Coil Embolization: A Single Center Experience.

Author: Sulemankhil I, Mohamed AH, and Gilani SA
Abstract: Coronary-pulmonary artery fistulas (CPF) are a rare malformation that is often asymptomatic but can be associated with dyspnea, angina, palpitation, dizziness, and syncope. Trans-catheter closure (TCC) with coil embolization is gaining prominence relative to surgical closure due to lower complications; however, there is a paucity of literature on the closure of CPFs with TCC. Here, we demonstrate a case series on the closure of a left anterior descending (LAD) artery to pulmonary artery (PA) fistula by advancing a guideliner into the coronary artery up to the origin of the coronary fistula in order to provide support for the advancement of the microcatheter and coil delivery., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Sulemankhil et al.)
Published: 2022
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42. Effects of visual scanning exercises in addition to task specific approach on balance and activities of daily livings in post stroke patients with eye movement disorders: a randomized controlled trial.

Author: Batool S, Zafar H, Gilani SA, Ahmad A, and Hanif A
Subjects: Activities of Daily Living, Exercise Therapy, Humans, Postural Balance physiology, Ocular Motility Disorders etiology, Stroke complications, Stroke therapy, Stroke Rehabilitation
Abstract: Background: Impaired vision is one of the commonest and most disabling consequence following stroke. Among all visual impairments, eye movement disorders are found in 70% of stroke patients which include nystagmus, strabismus, gaze palsies, disconjugate eye movements and cranial nerve palsies. They have a wide ranging impact on balance and activities of daily livings by creating difficulties in maintaining normal alignment and appropriate movement of eyes. The purpose of this study was to examine the effects of visual scanning exercises in addition to task specific approach on balance and activities of daily livings in post stroke patients with eye movement disorders., Methods: This study is a randomized controlled trial and was conducted in the University of Lahore Teaching Hospital from May 2019 to October 2020. A sample of 64 patients was recruited and randomly allocated into experimental and control group. 32 patients in experimental group were treated with visual scanning exercises along with task specific approach and 32 patients in control group were treated with task specific approach alone. Pre and post assessment of balance and activities of daily livings was assessed on BERG BALANCE SCALE and BARTHEL INDEX SCALE at baseline and at 4 th week., Results: Intra-group analysis of BERG BALANCE SCALE in experimental group showed statistically significant result (p < 0.05) in all items except in items 4, 13 and 14 respectively. Intra-group analysis of BERG BALANCE SCALE in control group showed statistically significant result (p < 0.05) in items 3, 5, 8 and 12 respectively, whereas remaining all items showed statistically insignificant result. Intra-group analysis of BARTHEL INDEX SCALE in experimental group showed statistically significant result in all items (p < 0.05) except in items 9 and 10 respectively. Intra-group analysis of BARTHEL INDEX in control group showed statistically significant result (p < 0.05) in items 1, 3, 4 and 8 respectively whereas remaining all items showed statistically insignificant result. Inter-group analysis showed statistically significant result in total scores of BERG BALANCE SCALE (p = 0.000) and BARTHEL INEX SCALE (p = 0.033)., Conclusion: Visual scanning exercises along with task specific approach were found to be more effective in comparison to task specific approach alone., Trial Registration: Trial registration number: [IRCT20190717044237N1], trial registration date: 10/11/2019., (© 2022. The Author(s).)
Published: 2022
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43. Translation and validation of stroke impact scale-16 in Urdu for Pakistan.

Author: Ahmed U, Karimi H, Gilani SA, and Ahmad A
Subjects: Male, Female, Humans, Reproducibility of Results, Pakistan, Prospective Studies, Psychometrics, Surveys and Questionnaires, Translations, Stroke
Abstract: Objective: To translate and validate the Urdu version of stroke impact scale-16 for Pakistani society., Methods: The prospective cohort study was conducted from February 2018 to February 2020 after approval from the ethics review board of The University of Lahore, Lahore, Pakistan, and copmprised patients with mild to moderate stroke who were recruited from five public and two private hospitals of the Punjab province. Established guidelines were followed to translate the Stroke Impact Scale-16. The patients were concurrently evaluated on Barthel Index, Stroke Rehabilitation Assessment of Movement, Modified Rivermead Mobility Index, Modified Rankin Scale, Short Form 36 Health Survey Questionnaire and the Hospital Anxiety and Depression Scale to assess the validity of Stroke Impact Scale-16, and spearmen correlation coefficient was used to determine the correlation among the scales. Analysis of variance was employed to determine the discriminant validity. Intraclass correlation coefficient, weighted kappa, Cronbach's alpha and item-total correlation were calculated to establish the stability and consistency of Stroke Impact Scale-16. Data was analysed using SPSS 25., Results: Of the 90 patients, 50(55.5%) were females and 40(45.5%) were males. The subjects were aged 50-80 years. The correlation of Stroke Impact Scale-16 was strong with the established tools and ranged from 0.78 to 0.91. The discriminant validity was also significant (p<.001) across all Modified Rankin Scale levels. The Intraclass correlation coefficient was 0.94 and Cronbach's alpha was 0.91 for test-retest reliability and internal consistency, respectively. All corrected item-total correlation values exceeded the priori minimum standard (>0.40) and ranged from 0.51 to 0.68. The weighted kappa for item reliability also achieved priori criteria (>0.40) and ranged from 0.53 to 0.88., Conclusion: With slight modifications, the Urdu version of Stroke Impact Scale-16 was found to have satisfactory psychometric properties and can be used in clinical and research settings for stroke survivors in Pakistan.
Published: 2022
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44. Translation, cross-cultural adaptation and psychometric properties of Urdu version of upper limb functional index; a validity and reliability study.

Author: Arooj A, Amjad F, Tanveer F, Arslan AU, Ahmad A, and Gilani SA
Subjects: Adult, Cross-Cultural Comparison, Disability Evaluation, Humans, Psychometrics, Reproducibility of Results, Surveys and Questionnaires, Upper Extremity, Language, Musculoskeletal Diseases diagnosis
Abstract: Background: The upper limb functional index is broadly used outcome measure for musculoskeletal disorders of the upper limb. The main objective of the study was to translate and validate the upper limb functional index (ULFI) outcome measure in the Urdu language., Methods: Upper limb functional index was translated into Urdu language using Beaton et al. guidelines through forward and backward translation along with the expert committee reviews. Two fifty (n = 250) Urdu-speaking patients with sub-acute or chronic conditions of upper limb musculoskeletal disorders were included in the study. The mean age was 32.33 ± 4.67 years. The data were collected from the physical therapy department of The University of Lahore Teaching hospital. All participants completed the upper limb functional index-Urdu (ULFI-U), Numeric pain rating scale (NPRS), Quick Disability of arm, shoulder, and hand (QuickDash), and (health survey) SF-12 at baseline while only ULFI-U at day three. Reliability was assessed through internal consistency by Cronbach's alpha and test-retest reliability by intra-class correlation (ICC). Content validity was measured by Lynn and Lawshee method. Spearman's correlation has been used to measure criterion validity. The construct validity was measured through hypothesis testing. The structural validity has been explained through factor analysis by exploratory factor analysis (EFA) using Maximum likelihood extraction (MLE) with Promax rotation., Results: The English version of ULFI was translated into the Urdu language with minor alterations. The Urdu version ULFI has demonstrated high levels of reliability with intra-class correlation (ICC 2,1= 0.91) and Cronbach's alpha (α = 0.94). The content validity index found as 0.808, the criterion validity for ULFI-U correlating with quick Dash was found excellent (r = 0.845) and ULFI-U established strong correlation with 6 domains of SF-12(r = 0.697 to 0.767) and weak correlation with its 2 domains and NPRS(r = 0.520). A two-factor structure was obtained using EFA., Conclusions: The ULFI-U is a valid and reliable patient-reported outcome (PRO) that can be used to assess upper limb musculoskeletal disorders in Urdu-speaking patients., Trial Registration: This study was registered in the U. S National Library on clinicaltrial.gov under registration no. NCT05088096 . (Date: 21/10/2021)., (© 2022. The Author(s).)
Published: 2022
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45. Effects of task oriented rehabilitation of upper extremity after stroke: A systematic review.

Author: Hussain M, Fatima A, Ahmad A, and Gilani SA
Subjects: Hand, Humans, Recovery of Function, Upper Extremity, Stroke, Stroke Rehabilitation methods
Abstract: Objective: To explore the current scientific evidence on the effects of task-oriented rehabilitation programme of upper extremity post-stroke., Methods: The systematic review comprised studies from 2012 to August 2020 which were both Hand-searched and explored on Cochrane, PubMed, PEDro and MEDLINE databases with authentic search techniques using population-intervention-control-outcomes format and Boolean operator. Randomised controlled trials on the use of task-oriented training for the improvement of upper extremity functional outcomes in subjects with stroke were shortlisted and reviewed. The risk bias tool was used to evaluate the biasness in the studies and the PEDro scale was used to evaluate the methodological quality of the studies., Results: Of the 28 articles assessed, 16(%) were included for detailed review. All studies varied significantly with PEDro scores between 6 and 10. There were 12(75%) high-quality studies and 4(25%) fell in fair category. All the studies showed significant results in the improvement of upper extremity after stroke through task-oriented training rehabilitation (p<0.05)., Conclusions: Evidence supports the beneficial effects of task-oriented rehabilitation for the improvement of upper extremity functions post-stroke.
Published: 2022
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46. Virtual Reality Training Using Nintendo Wii Games for Patients With Stroke: Randomized Controlled Trial.

Author: Anwar N, Karimi H, Ahmad A, Gilani SA, Khalid K, Aslam AS, and Hanif A
Abstract: Background: Stroke is a leading cause of disability. It is difficult to devise an optimal rehabilitation plan once stroke survivors are back home. Conventional rehabilitative therapies are extensively used in patients with stroke to recover motor functioning and disability, but these are arduous and expensive. Virtual reality (VR) video games inspire patients to get involved in their therapeutic exercise routine in a fun way. VR in the form of games provides a fruitful, secure, and challenging learning environment for motor control and neural plasticity development in rehabilitation. The effects of upper limb sensorimotor functioning and balance are the main focus of this trial., Objective: The aim of this study is to compare the effects of VR training and routine physical therapy on balance and upper extremity sensorimotor function in patients with stroke., Methods: It was a single assessor-blinded randomized clinical trial. A total of 74 participants with their first chronic stroke were included and rehabilitated in a clinical setting. The lottery method was used to randomly assign patients to either the VR group (n=37) or the routine physical therapy group (n=37). The VR group received a 1-hour session of VR training for 3 weekdays over 6 weeks, and the routine physical therapy group received different stretching and strengthening exercises. The outcome measuring tools were the Berg Balance Scale for balance and the Fugl-Meyer Assessment (upper extremity) scale for sensorimotor, joint pain, and range assessment. The assessment was done at the start of treatment and after the 6 weeks of intervention. Data analysis was done using SPSS 22., Results: The trial was completed by 68 patients. A significant difference between the two groups was found in the Berg Balance Scale score (P<.001), Fugl-Meyer Assessment for motor function (P=.03), and Fugl-Meyer Assessment for joint pain and joint range (P<.001); however, no significant difference (P=.19) in the Fugl-Meyer Assessment for upper extremity sensation was noted., Conclusions: VR training is helpful for improving balance and function of the upper extremities in the routine life of patients with stroke; although, it was not found to be better than conventional training in improving upper limb sensation. VR training can be a better option in a rehabilitation plan designed to increase functional capability., Trial Registration: Iranian Registry of Clinical Trials RCT20190715044216N1; https://www.irct.ir/user/trial/40898/view., (©Naveed Anwar, Hossein Karimi, Ashfaq Ahmad, Syed Amir Gilani, Kehkshan Khalid, Ahmed Sohaib Aslam, Asif Hanif. Originally published in JMIR Serious Games (https://games.jmir.org), 13.06.2022.)
Published: 2022
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47. Correlation Analysis Between Pain Intensity, Functional Disability and Range of Motion Using Low-Level Laser Therapy in Patients With Discogenic Lumbar Radiculopathy: A Cross-sectional Study.

Author: Ahmed I, Mohseni Bandpei MA, Gilani SA, Ahmad A, and Zaidi F
Abstract: Introduction: Low-level laser is a pain-free and non-invasive treatment modality. It is used in many acute and chronic painful conditions. This study aimed to determine the correlation between pain intensity, functional disability, and range of motion using low-level laser therapy (LLLT) in patients with discogenic lumbar radiculopathy. Methods: This cross-sectional study was conducted as a part of a randomized controlled trial of LLLT to treat patients with discogenic lumbar radiculopathy in physical therapy departments of three different hospitals in Islamabad, Pakistan, from August 2021 to September 2021. The study was conducted according to STROBE guidelines. Fifty-Five patients from the experimental group of the trial were invited to participate in this study. The outcomes of the treatment were recorded on a semi-structured questionnaire on the first day and last day of their treatment from each patient's pain intensity, functional disability, and Lumbar range of motion (L-ROM) (flexion and extension) by using the visual analogue scale (VAS) for pain intensity, Oswestry Disability Index (ODI) for functional disability, and dual inclinometer for L-ROM. The data were analyzed through SPSS version 26.0. Results: The results of the correlation coefficient/Pearson's correlation of VAS, ODI, and dual inclinometer were varied. The strength of correlation between variables was weak to moderate (r=0.033 to 0.425) with statistically insignificant correlation coefficient ( P > 0.05, 95% CI) except for lumbar flexion ( P <0.05, 95% CI). Conclusion: For acute low back pain (LBP) with discogenic lumbar radiculopathy, LLLT at a wavelength of 830-nm and a dose of 3J/point in conjunction with conventional physical therapy had no significant correlation, but rather weak to moderate values with pain intensity, functional disability, and L-ROM., Competing Interests: All authors declare that they do not have any competing interests., (Copyright © 2022 J Lasers Med Sci.)
Published: 2022
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48. Digital technologies in management of chronic pain - a systematic review.

Author: Hussain A, Haroon H, Ahmed A, and Gilani SA
Subjects: Digital Technology, Exercise, Exercise Therapy methods, Humans, Chronic Pain therapy
Abstract: Objective: To determine the effectiveness of digital health technologies in the management of chronic pain., Methods: The systematic review comprised search for randomised controlled trials and controlled clinical trials involving patients with chronic pain published between 2010 and 2020. The search was conducted on PubMed, Google Scholar, MEDLINE, National Centre for Biotechnology Information, and National Library of Medicine databases. Risk bias tool was used to evaluate the biasness in the studies and Pedro scale was used to assess the quality of the included articles., Results: Of the 33 articles fully assessed, 14(42.42%) were analysed. All the studies analysed were randomised controlled trials and scored 6-10 on the Pedro scale which showed high quality of methodology. The studies typically reported statistically significant benefits of digital health technologies in the management of chronic pain. One of the main benefits was enhanced pain coping skills of the patients. Additionally, majority of the studies included increased adherence to exercise as an essential advantage., Conclusions: All the studies analysed reported favourable conclusions regarding the use of digital intervention for chronic pain management.
Published: 2022
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49. Interobserver agreement on the sonographic severity grading of shoulder impingement syndrome.

Author: Bacha R, Gilani SA, Hanif A, and Manzoor I
Abstract: Background: Shoulder impingement syndrome is the painful entrapment of the soft tissues between the acromion and the humeral head. The severity of shoulder impingement could be graded according to the limitation of shoulder joint moment. The reliability of sonographic findings in the grading of shoulder impingement severity grading is required to be evaluated by the consistency of findings between the observers., Purpose: To assess the interobserver agreement in the sonographic severity grading of shoulder impingement syndrome with the help of a ratio between acromion-to-greater tuberosity distance in the abduction and neutral arm position., Material and Methods: Patients were examined by two independent observers in the coronal approach with neutral arm position. Acromion-to-greater tuberosity distance was measured in abduction and neutral shoulder position. The ratios of the distances in the abduction and neutral position were calculated to grade the severity of shoulder impingement syndrome., Results: A total of 78 shoulders were included in this study. A strong agreement was found for the grading of shoulder impingement severity grading between the two independent observers with Kappa value of 0.94. And correlation between the results of the two observers for the severity grading of shoulder impingement syndrome was significant at 0.01 level., Conclusion: Severity grading of the shoulder impingement syndrome was performed based on the ratio of acromion-to-greater tuberosity distance in abduction and neutral arm position. However, the sonographic findings were consistent and a strong interobserver agreement was seen in this sonographic severity grading., (© 2022. The Author(s).)
Published: 2022
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50. Subacromial Content to Subacromial Space Ratio in Neutral Position of the Arm as Diagnostic Criteria of Subacromial Impingement Syndrome.

Author: Bacha R, Gilani SA, Hanif A, and Manzoor I
Abstract: Background: Shoulder impingement syndrome is one of the main causes of shoulder disability of working-class individuals. Currently, dynamic sonography of the shoulder is the modality of choice for the evaluation of shoulder impingement syndrome. The ratio of subacromial contents (SAC) and subacromial space (SAS) in neutral arm position could be used as a diagnostic parameter for the subacromial impingement syndrome (SIS), especially in patients who have difficulties in the elevation of their shoulders due to pain. To use the SAC to SAS ratio as a sonographic criterion for the diagnosis of SIS., Methods: SAC and SAS of 772 shoulders were vertically measured in coronal view with linear transducer 7-14MHz of Toshiba Xario Prime ultrasound unit, while the patient arm was kept in the neutral position. The ratio of both the measurements was calculated, to be used as a diagnostic parameter of the SIS., Results: The mean SAS was 10.79 ± 1.94 mm and SAC was 7.65 ± 1.43 mm. SAC-to-SAS ratio for normal shoulders was a focused value with narrow standard deviation (0.66 ± 0.03). However, shoulder impingement is confirmed by any value falls out of the range of ratio for normal shoulders. Area under the curve at 95% confidence interval was 96%, while the sensitivity at 95% confidence interval was 99.25% (97.83%-99.85%), and specificity was 80.86% (76.48%-84.74%)., Conclusion: SAC-to-SAS ratio in neutral arm position is a relatively more accurate sonographic technique for the diagnosis of SIS., Competing Interests: There are no conflicts of interest., (Copyright: © 2022 Journal of Medical Ultrasound.)
Published: 2022
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