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Music educators and clinicians from Ohio and across the country gather annually for the Ohio Music Education Association (OMEA) professional development conference. Dr. Phillip Hash, professor and researcher from Illinois State University, was the featured keynote speaker of the Graduate Research Forum in February 2023. Hash has presented on primary topics of music education history, instrumental music pedagogy, student teacher mentoring, and music teacher evaluation. Not only is he a notable scholar in the field, but also an accomplished arranger for band, strings, and small instrumental ensembles. The focus of this research forum centered on the historical development of popular music in the United States spanning from the 17th-century to present day, along with implications for practice in the music teaching and learning community.

Exercise training has proven to be beneficial in the prevention of disease. In addition, exercise can improve the pathogenesis and symptoms associated with a variety of chronic disease states and can attenuate drug-induced adverse effects. Exercise is a drug-free polypill. Because the benefits of exercise are clear and profound, Exercise is Medicine, a joint initiative between the American Medical Association and American College of Sports Medicine, was launched in 2007 to call on all health care providers to counsel patients and prescribe exercise in the prevention and treatment of chronic disease states. Pharmacists play an increasing role in direct patient care and are the most accessible health care providers in the community. Thus, pharmacists should be knowledgeable in counseling patients on the frequency, intensity, time, and type of exercise that is appropriate for various conditions and disease states. The aim of the present study was to determine the prevalence of didactic course offerings in United States pharmacy school curricula regarding training in exercise prescription. School websites were accessed for information regarding course offerings in PharmD programs. No United States pharmacy schools offered courses that were dedicted to the role of exercise in disease prevention or exercise prescription in disease management. Ninety percent of pharmacy schools did not offer courses with the keywords "exercise," "fitness, or "physical activity" in the title or description. The data suggest that student pharmacists are not adequately trained to counsel patients on the benefits of exercise or exercise prescription.

Music educators and clinicians from Ohio and across the country gather annually for the Ohio Music Education Association (OMEA) professional development conference . Dr . Phillip Hash, professor and researcher from Illinois State University, was the featured keynote speaker of the Graduate Research Forum in February 2023 . Hash has presented on primary topics of music education history, instrumental music pedagogy, student teacher mentoring, and music teacher evaluation . Not only is he a notable scholar in the field, but also an accomplished arranger for band, strings, and small instrumental ensembles . The focus of this research forum centered on the historical development of popular music in the United States spanning from the 17th-century to present day, along with implications for practice in the music teaching and learning community . [ABSTRACT FROM AUTHOR]

The synthesis of paclitaxel-gold nanoparticles hybrid structures is described and standard analytical methods are used for observing the covalent attachment of paclitaxel molecules to the surface of 2 nm gold nanocrystals. This approach has provided an opportunity for preparing hybrid particles with a well-defined amount of drug and has offered a new alternative for the design of nanosized drug-delivery systems.

A simple and very efficient method to produce Au nanoparticles (NPs) with an equal number of hydrophobic and hydrophilic arms, which are distributed along the surface of Au NP in an alternating fashion, is described. When the product is isolated, the average number of V-shaped molecules per particle could be estimated on the basis of the weight gain and the assumption that 2-nm gold clusters contain 270 atoms.

A sublingually delivered heterologous antigen presentation platform that does not depend on antigen or adjuvant purification would be of great benefit in protection against diarrheal disease. In proof-of-concept studies, we previously showed that when a fusion protein comprised of the Vibrio cholerae biofilm matrix protein RbmA and the B subunit of cholera toxin (R-CTB) is expressed from a plasmid within V. cholerae, R-CTB is sequestered in the biofilm matrix, leading to decoration of the cell surface. Sublingual delivery of live attenuated R-CTB-decorated cells results in a mucosal immune response to CTB. To improve the immune response to diarrheal antigens presented by this platform, we have engineered our live attenuated vaccine to express the mucosal adjuvant mmCT (i.e., multiply mutated CT). Here we report that delivery of this adjuvant via sublingual administration of our vaccine enhances the mucosal immune response to V. cholerae LPS and elicits a systemic and mucosal immune response to CTB. However, provision of R-CTB with mmCT selectively blunts the mucosal immune response to CTB. We propose that mmCT delivered by this live attenuated Vibrio cholerae vaccine platform may serve as a mucosal adjuvant for heterologous antigens, provided they are not too similar to mmCT. IMPORTANCE: Diarrheal disease is the most common infectious disease of children in the developing world. Our goal is to develop a diarrheal antigen presentation platform based on whole Vibrio cholerae cells that does not depend on protein purification. We have previously shown the feasibility of genetically fusing antigens to the V. cholerae biofilm matrix protein RbmA for presentation on the cell surface. A mucosal adjuvant could improve immunogenicity of such a vaccine at the mucosal surface. Here we engineer a live attenuated V. cholerae vaccine to constitutively synthesize mmCT, a nontoxic form of cholera toxin. When this vaccine is delivered sublingually, in vivo-synthesized mmCT acts as both an adjuvant and antigen. This could greatly increase the magnitude and duration of the immune response elicited by codelivered heterologous antigens.

Gold nanoparticles functionalized with amphiphilic polybutadiene-poly(ethylene glycol) (PB-PEG) V-shaped arms formed stable Langmuir monolayers at the air-water and the air-solid interfaces. At these interfaces, the binary arms vertically segregated into a dense polymer corona, which surrounded the gold nanoparticles, preventing their large-scale agglomeration and keeping individual nanoparticles well-separated from each other and forming flattened, pancake nanostructures. The presence of both PEG and PB chains in the close proximity to the gold core was confirmed by surface enhanced Raman spectroscopy, whereas the AFM phase contrast images revealed the presence of 2 nm gold cores surrounded by the polymer shell with the diameter of 11 nm. We suggest that the amphiphilic shell drives their spontaneous organization into discrete 2D pancake-like hybrid structures that measured up to 10 microm in diameter and had a high packing density of gold clusters.