1. Evaluation of proton beam radiation-induced skin injury in a murine model using a clinical SOBP
- Author
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Pietro Pisciotta 1, 2, 3, Angelita Costantino 4, Francesco Paolo Cammarata 2, Filippo Torrisi 3, 4, Giovanna Calabrese 4, Valentina Marchese 4, 5, Giuseppe Antonio Pablo Cirrone 3, Giada Petringa 3, Giusi Irma Forte 2, Luigi Minafra 2, Valentina Bravatà 2, Massimo Gulisano 6, 7, Fabrizio Scopelliti 8, Francesco Tommasino 9, Emanuele Scifoni 10, Giacomo Cuttone 3, Massimo Ippolito 11, Rosalba Parenti 4, and Giorgio Russo 2
- Subjects
Physiology ,Cancer Treatment ,Bragg peak ,Pathology and Laboratory Medicine ,Nervous System ,030218 nuclear medicine & medical imaging ,Mice ,Myelopathy ,Injury Severity Score ,0302 clinical medicine ,Medicine and Health Sciences ,Proton Therapy ,Proton beam radiation ,Skin ,Multidisciplinary ,VALUES ,Pharmaceutics ,Physics ,Animal Models ,Dose–response relationship ,Experimental Organism Systems ,Physiological Parameters ,Spinal Cord ,Oncology ,Research Design ,030220 oncology & carcinogenesis ,Physical Sciences ,Observational Studies ,Medicine ,Protons ,Anatomy ,Animals ,Disease Models, Animal ,Dose-Response Relationship, Radiation ,Radiation Injuries ,Research Article ,Science ,Sobp ,Mouse Models ,Dermatology ,Research and Analysis Methods ,BIOLOGICAL EFFECTIVENESS RBE ,03 medical and health sciences ,Model Organisms ,Dose Prediction Methods ,Signs and Symptoms ,Diagnostic Medicine ,medicine ,Irradiation ,Nuclear Physics ,Nucleons ,Skin Injury ,business.industry ,Body Weight ,Biology and Life Sciences ,medicine.disease ,Neuroanatomy ,Erythema ,Animal Studies ,Nuclear medicine ,business ,Neuroscience - Abstract
The purpose of this paper is to characterize the skin deterministic damage due to the effect of proton beam irradiation in mice occurred during a long-term observational experiment. This study was initially defined to evaluate the insurgence of myelopathy irradiating spinal cords with the distal part of a Spread-out Bragg peak (SOBP). To the best of our knowledge, no study has been conducted highlighting high grades of skin injury at the dose used in this paper. Nevertheless these effects occurred. In this regard, the experimental evidence of significant insurgence of skin injury induced by protons using a SOBP configuration will be shown. Skin damages were classified into six scores (from 0 to 5) according to the severity of the injuries and correlated to ED50 (i.e. the radiation dose at which 50% of animals show a specific score) at 40 days post-irradiation (d.p.i.). The effects of radiation on the overall animal wellbeing have been also monitored and the severity of radiation-induced skin injuries was observed and quantified up to 40 d.p.i.
- Published
- 2020