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Evaluation of proton beam radiation-induced skin injury in a murine model using a clinical SOBP
- Source :
- PloS one 15 (2020): e0233258. doi:10.1371/journal.pone.0233258, info:cnr-pdr/source/autori:Pietro Pisciotta 1,2,3*, Angelita Costantino 4*, Francesco Paolo Cammarata 2,3, Filippo Torrisi 3,4, Giovanna Calabrese 4, Valentina Marchese 4,5, Giuseppe Antonio Pablo Cirrone 3, Giada Petringa 3, Giusi Irma Forte 2, Luigi Minafra 2, Valentina Bravatà 2, Massimo Gulisano 6,7, Fabrizio Scopelliti 8, Francesco Tommasino 9,10, Emanuele Scifoni 10, Giacomo Cuttone 3, Massimo Ippolito 11, Rosalba Parenti 4,5,7, Giorgio Russo 2,3/titolo:Evaluation of Proton Beam Radiation-Induced Skin Injury in a Murine Model Using a Clinical SOBP/doi:10.1371%2Fjournal.pone.0233258/rivista:PloS one/anno:2020/pagina_da:e0233258/pagina_a:/intervallo_pagine:e0233258/volume:15, PLoS ONE, PLoS ONE, 15(5):0233258. PUBLIC LIBRARY SCIENCE, PLoS ONE, Vol 15, Iss 5, p e0233258 (2020)
- Publication Year :
- 2020
-
Abstract
- The purpose of this paper is to characterize the skin deterministic damage due to the effect of proton beam irradiation in mice occurred during a long-term observational experiment. This study was initially defined to evaluate the insurgence of myelopathy irradiating spinal cords with the distal part of a Spread-out Bragg peak (SOBP). To the best of our knowledge, no study has been conducted highlighting high grades of skin injury at the dose used in this paper. Nevertheless these effects occurred. In this regard, the experimental evidence of significant insurgence of skin injury induced by protons using a SOBP configuration will be shown. Skin damages were classified into six scores (from 0 to 5) according to the severity of the injuries and correlated to ED50 (i.e. the radiation dose at which 50% of animals show a specific score) at 40 days post-irradiation (d.p.i.). The effects of radiation on the overall animal wellbeing have been also monitored and the severity of radiation-induced skin injuries was observed and quantified up to 40 d.p.i.
- Subjects :
- Physiology
Cancer Treatment
Bragg peak
Pathology and Laboratory Medicine
Nervous System
030218 nuclear medicine & medical imaging
Mice
Myelopathy
Injury Severity Score
0302 clinical medicine
Medicine and Health Sciences
Proton Therapy
Proton beam radiation
Skin
Multidisciplinary
VALUES
Pharmaceutics
Physics
Animal Models
Dose–response relationship
Experimental Organism Systems
Physiological Parameters
Spinal Cord
Oncology
Research Design
030220 oncology & carcinogenesis
Physical Sciences
Observational Studies
Medicine
Protons
Anatomy
Animals
Disease Models, Animal
Dose-Response Relationship, Radiation
Radiation Injuries
Research Article
Science
Sobp
Mouse Models
Dermatology
Research and Analysis Methods
BIOLOGICAL EFFECTIVENESS RBE
03 medical and health sciences
Model Organisms
Dose Prediction Methods
Signs and Symptoms
Diagnostic Medicine
medicine
Irradiation
Nuclear Physics
Nucleons
Skin Injury
business.industry
Body Weight
Biology and Life Sciences
medicine.disease
Neuroanatomy
Erythema
Animal Studies
Nuclear medicine
business
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PloS one 15 (2020): e0233258. doi:10.1371/journal.pone.0233258, info:cnr-pdr/source/autori:Pietro Pisciotta 1,2,3*, Angelita Costantino 4*, Francesco Paolo Cammarata 2,3, Filippo Torrisi 3,4, Giovanna Calabrese 4, Valentina Marchese 4,5, Giuseppe Antonio Pablo Cirrone 3, Giada Petringa 3, Giusi Irma Forte 2, Luigi Minafra 2, Valentina Bravatà 2, Massimo Gulisano 6,7, Fabrizio Scopelliti 8, Francesco Tommasino 9,10, Emanuele Scifoni 10, Giacomo Cuttone 3, Massimo Ippolito 11, Rosalba Parenti 4,5,7, Giorgio Russo 2,3/titolo:Evaluation of Proton Beam Radiation-Induced Skin Injury in a Murine Model Using a Clinical SOBP/doi:10.1371%2Fjournal.pone.0233258/rivista:PloS one/anno:2020/pagina_da:e0233258/pagina_a:/intervallo_pagine:e0233258/volume:15, PLoS ONE, PLoS ONE, 15(5):0233258. PUBLIC LIBRARY SCIENCE, PLoS ONE, Vol 15, Iss 5, p e0233258 (2020)
- Accession number :
- edsair.doi.dedup.....38c44714d45e8e16cdb7e2c5a0dfc524