Search

Your search keyword '"George N. Magrath"' showing total 26 results
Start Over Author "George N. Magrath"
26 results on '"George N. Magrath"'

1. Retinoblastoma with and without Extraocular Tumor Extension

Author

Swathi Kaliki, MD, Vijitha S. Vempuluru, MD, Ido Didi Fabian, MD, Elhassan Abdallah, MD, Shehu U. Abdullahi, MD, Rula A. Abdulqader, MD, Aminatu A. Abdulrahaman, MD, Sherif Abouelnaga, MD, Dupe S. Ademola-Popoola, FMCOph, FWACS, Adedayo Adio, FWACS, Mahmoud A. Afifi, MD, Armin R. Afshar, MD, Priyanka Aggarwal, MD, Ada E. Aghaji, FMCOph MSc, Alia Ahmad, MRCPCH UK, Marliyanti N.R. Akib, MD, Adeseye M. Akinsete, MBBS, Lamis Al Harby, MD, Saleh A. Al Mesfer, MD, Mouroge H. Al Ani, MD, Silvia Alarcón Portabella, MD, Safaa A.F. Al-Badri, MD, Ana Patricia A. Alcasabas, MD, Saad A. Al-Dahmash, MD, Amanda Alejos, MD, Ernesto Alemany-Rubio, MD, Amadou I. Alfa Bio, MD, Yvania Alfonso Carreras, MD, Christiane E. Al-Haddad, MD, Hamoud H.Y. Al-Hussaini, MD, MSc, Amany M. Ali, MD, Donjeta B. Alia, MD, Mazin F. Al-Jadiry, MD, Usama Al-Jumaly, MD, Hind M. Alkatan, MD, Charlotta All-Eriksson, MD, PhD, Ali A.R.M. Al-Mafrachi, FIBMS, Argentino A. Almeida, MD, Khalifa M. Alsawidi, MD, Athar A.S.M. Al-Shaheen, MD, Entissar H. Al-Shammary, MD, Doreen Amankwaa-Frempong, MBChB, Primawita O. Amiruddin, MD, Inggar Armytasari, MD, Nicholas J. Astbury, FRCS, FRCOphth, Hatice T. Atalay, MD, Eda Ataseven, MD, La-ongsri Atchaneeyasakul, MD, Rose Atsiaya, OCO, Rudolf Autrata, MD, PhD, Julia Balaguer, MD, PhD, Ruhengiz Balayeva, PhD, Honorio Barranco, MD, PhD, Paulina Bartoszek, MD, Katarina Bartuma, MD, PhD, Covadonga Bascaran, MD, MSc, Nikolaos E. Bechrakis, MD, Maja Beck Popovic, MD, Ainura S. Begimkulova, MD, Sarra Benmiloud, MD, Rokia C. Berete, MD, PhD, Jesse L. Berry, MD, Anirban Bhaduri, MD, Sunil Bhat, MBBS, MD, Arpita Bhattacharyya, MD, Eva M. Biewald, MD, Elaine Binkley, MD, Sharon Blum, MD, Nadia Bobrova, MD, H. Culver Boldt, MD, Maria Teresa B.C. Bonanomi, MD, PhD, Gabrielle C. Bouda, MD, Hédi Bouguila, MD, PhD, Rachel C. Brennan, MD, Bénédicte G. Brichard, MD, PhD, Jassada Buaboonnam, MD, Aléine Budiongo, MD, Matthew Burton, FRCOphth, Patricia Calderón-Sotelo, MD, Doris A. Calle Jara, MD, Jayne E. Camuglia, FRANZCO, Miriam R. Cano, MD, MSc, Michael Capra, FRCPI, Shani Caspi, MD, Nathalie Cassoux, MD, PhD, Guilherme Castela, MD, Luis Castillo, MD, Jaume Català-Mora, MD, PhD, Isabel Caviedes, MD, Arthika Chandramohan, MD, Guillermo L. Chantada, MD, PhD, Shabana Chaudhry, MD, Bhavna Chawla, MD, Wensi Chen, MD, Faraja S. Chiwanga, MSc, Tsengelmaa Chuluunbat, MD, PhD, Krzysztof Cieslik, MD, Antony Clark, FRANZCO, Ruellyn L. Cockcroft, MB ChB , M Med Paed, Codruta Comsa, MD, Maria G. Correa Llano, MD, Timothy W. Corson, PhD, Line Couitchere, MD, Kristin E. Cowan-Lyn, MD, MBBS, Monika Csóka, MD, PhD, Wantanee Dangboon, MD, Anirban Das, MD, Pranab Das, MD, Sima Das, MS, Jacquelyn M. Davanzo, BSN, BSPH, Alan Davidson, MBChB, MPhil, Sonia De Francesco, MD, Patrick De Potter, MD, PhD, Karina Q. Delgado, MD, PhD, Hakan Demirci, MD, Laurence Desjardins, MD, Rosdali Y. Diaz Coronado, MD, Helen Dimaras, PhD, Andrew J. Dodgshun, M Phil, Carla R. Donato Macedo, MD, Monica D. Dragomir, MD, PhD, Yi Du, MD, Magritha Du Bruyn, MD, Johannes P. Du Plessis, MMed (Paed), Gagan Dudeja, MBBS, MS, Katrin Eerme, MD, I Wayan Eka Sutyawan, MD, Asmaa El Kettani, MD, Amal M. Elbahi, MD, James E. Elder, MBBS, Alaa M. Elhaddad, MD, PhD, Moawia M.A. Elhassan, MD, Mahmoud M. Elzembely, MD, Connor Ericksen, MD, Vera A. Essuman, FWACS, Ted Grimbert A. Evina, MD, Ifeoma R. Ezegwui, FMCOph, FWACS, FAEH, Zehra Fadoo, MBBS, Adriana C. Fandiño, MD, Mohammad Faranoush, MD, Oluyemi Fasina, FWACS, Delia D.P.G. Fernández, MSc, Ana Fernández-Teijeiro, MD, PhD, Allen Foster, FRCOphth, Shahar Frenkel, MD, PhD, Ligia D. Fu, MD, Soad L. Fuentes-Alabi, MD, MPH, Juan L. Garcia, MSc, David García Aldana, MD, Henry N. Garcia Pacheco, MD, Jennifer A. Geel, MBChB, MMed, Fariba Ghassemi, MD, Ana V. Girón, MD, Marco A. Goenz, MD, Aaron S. Gold, OD, Hila Golberg, MD, Glen A. Gole, MD, FRANZCO, Nir Gomel, MD, Efren Gonzalez, MD, Graciela Gonzalez Perez, MD, Liudmira González-Rodríguez, MD, Malka Gorfine, PhD, Jaime Graells, MD, Pernille A. Gregersen, MD, Nathalia D.A.K. Grigorovski, MD, Koffi M. Guedenon, MD, D Sanjeeva Gunasekera, MD, Ahmet K. Gündüz, MD, Himika Gupta, MD, Sanjiv Gupta, MS, Vineeta Gupta, MD, Theodora Hadjistilianou, MD, Patrick Hamel, MD, Syed A. Hamid, FCPS, Norhafizah Hamzah, MSc, Eric D. Hansen, MD, J William Harbour, MD, M. Elizabeth Hartnett, MD, Murat Hasanreisoglu, MD, Sadiq Hassan, MD, FWACS, Shadab Hassan, FRCS, FCPS, Wojciech Hautz, MD, Huda A. Haydar, CHD, Stanislava Hederova, MD, Laila Hessissen, MD, Hoby Lalaina, MD, Suradej Hongeng, MD, Diriba F. Hordofa, MD, G. Baker Hubbard, MD, Marlies Hummlen, MD, Kristina Husakova, MD, Allawi N. Hussein Al-Janabi, MD, Affiong A. Ibanga, MB.BCh, FMCOph, Russo Ida, MD, Vesna R. Ilic, MD, Ziyavuddin Islamov, MD, Vivekaraj Jairaj, DNB, Teyyeb A. Janjua, MD, FCPS, FRCSEd, Irfan Jeeva, FRCOphth, Xunda Ji, MD, Dong Hyun Jo, MD, PhD, Michael M. Jones, MD, PhD, FRANZCO, Theophile B. Amani Kabesha, MD, PhD, Rolande L. Kabore, MD, Abubakar Kalinaki, MD, Pius Kamsang, MD, Mehmet Kantar, MD, Noa Kapelushnik, MD, Tamar Kardava, PhD, Rejin Kebudi, MD, Jonny Keomisy, MD, Tomas Kepak, MD, Petra Ketteler, MD, Zohora J. Khan, MD, Hussain A. Khaqan, MD, Vikas Khetan, FRCS, FACS, Alireza Khodabande, MD, Zaza Khotenashvili, MD, Jonathan W. Kim, MD, Jeong Hun Kim, MD, PhD, Hayyam Kiratli, MD, Tero T. Kivelä, MD, Artur Klett, MD, PhD, Irem Koç, MD, Jess Elio Kosh Komba Palet, MD, Dalia Krivaitiene, MD, PhD, Mariana Kruger, Mmed Paed, PhD, Kittisak Kulvichit, MD, Mayasari W. Kuntorini, MD, Alice Kyara, BA, Geoffrey C. Lam, FRANZCO, Scott A. Larson, MD, Slobodanka Latinović, MD, PhD, Kelly D. Laurenti, MD, Yotam Lavi, MD, PhD, Alenka Lavric Groznik, MD, Amy A. Leverant, MD, Cairui Li, MD, Kaijun Li, MD, Ben Limbu, MD, Chun-Hsiu Liu, MD, Quah Boon Long, FRCS (Ed), MMed ( Ophth), FAMS, Juan P. López, MD, Robert M. Lukamba, MD, Sandra Luna-Fineman, MD, Delfitri Lutfi, MD, Lesia Lysytsia, MD, Shiran Madgar, MD, George N. Magrath, MD, Amita Mahajan, MD, Puja Maitra, MD, Erika Maka, MD, Emil K. Makimbetov, MD, Azza M.Y. Maktabi, MD, Carlos Maldonado, MD, Ashwin Mallipatna, MD, Rebecca Manudhane, MD, Lyazat Manzhuova, MD, Nieves Martín Begue, MD, PhD, Sidra Masud, MBBS, Ibrahim O. Matende, MD, M. Med (Oph), Clarissa C.D.S. Mattosinho, MD, Marchelo Matua, BAPH, Ismail Mayet, MD, Freddy B. Mbumba, MD, MMed Paed, John D. McKenzie, MD, Azim Mehrvar, MD, Aemero A. Mengesha, MD, Vikas Menon, MD, Gary John V.D.D. Mercado, MD, Marilyn B. Mets, MD, Edoardo Midena, MD, PhD, Audra Miller, MD, Divyansh K.C. Mishra, DNB, Furahini G. Mndeme, MD, Ahmed A. Mohamedani, FRCPath, Mona T. Mohammad, MD, FRCS, Annette C. Moll, MD, PhD, Margarita M. Montero, MD, Claude Moreira, MD, PhD, Prithvi Mruthyunjaya, MD, MHS, Mchikirwa S. Msina, MMed Ophth, Gerald Msukwa, MMed Ophth, Sangeeta S. Mudaliar, DNB Pediatric, Hassan Muhammad, MD, Kangwa I. Muma, MMed Ophth, FCOphth, Francis L. Munier, MD, Timothy G. Murray, MD, MBA, Kareem O. Musa, FWACS, FMCOphth, FICO, Asma Mushtaq, MD, Anne A. Musika, MD, Hamzah Mustak, MD, Tajudeen Mustapha, MBBS, FWACS, Okwen M. Muyen, MD, Khumo H. Myezo, Msc, Gita Naidu, MMed Paed, PhD, Natasha Naidu, MBCHB, FCS Ophthalmol, Akshay Gopinathan Nair, MD, Sundaram Natarajan, FRCS, Larisa Naumenko, MD, PhD, Paule Aïda Ndoye Roth, MD PhD, Yetty M. Nency, MD, Vladimir Neroev, MD, PhD, Yvonne Ng, MBChB ( Auckland) , FRANZCO, Marina Nikitovic, MD, PhD, Elizabeth D. Nkanga, FMCOph, Henry E. Nkumbe, MD, Marcel N. Numbi, MD, Kalle Nummi, MD, Murtuza Nuruddin, FRCS, Mutale Nyaywa, MD, MMed Ophth, FCOphth, Chinsisi Nyirenda, MD, Ghislaine Obono-Obiang, MD, Scott C.N. Oliver, MD, Joaquin Ooporto, MD, Miriam Ortega-Hernández, MD, Alexander Oscar, MD, Diego Ossandon, MD, Halimah Pagarra, MD, PhD, Vivian Paintsil, FWACP, Luisa Paiva, MD, Mahesh Shanmugam Palanivelu, FRCSED, Ruzanna Papyan, MD, Raffaele Parrozzani, MD, PhD, Claudia R. Pascual Morales, MD, Katherine E. Paton, MD, FRCSC, Jacob Pe'er, MD, Jesús Peralta Calvo, MD, Sanja Perić, MD, PhD, Chau T.M. Pham, MD, Remezo Philbert, MD, David A. Plager, MD, Pavel Pochop, MD, PhD, Rodrigo A. Polania, MD, Vladimir Polyakov, MD, Jimena Ponce, MD, Ali O. Qadir, MD, Seema Qayyum, FCPS, Jiang Qian, MD, Ardizal Rahman, MD, Purnima Rajkarnikar, MD, Rajesh Ramanjulu, MD, Aparna Ramasubramanian, MD, Marco A. Ramirez-Ortiz, MD, MPH, Jasmeen K. Randhawa, BA, Léa Raobela, MD, Riffat Rashid, MS, M. Ashwin Reddy, FRCOphth, Lorna A. Renner, FRCPCH (UK), David Reynders, MD, Dahiru Ribadu, FMCOph, Petra Ritter-Sovinz, MD, Anna Rogowska, MD, Duangnate Rojanaporn, MD, Livia Romero, MD, Soma R. Roy, DCO, Raya H. Saab, MD, Svetlana Saakyan, MD, PhD, Ahmed H. Sabhan, MD, Mandeep S. Sagoo, FRCS (Ed), Azza M.A. Said, MD, Rohit Saiju, MD, Beatriz Salas, MD, Sonsoles San Román Pacheco, MD, Gissela L. Sánchez, MD, Alma Janeth Sanchez Orozco, MD, Phayvanh Sayalith, MD, Trish A. Scanlan, MRCPI, MSc, Christoph Schwab, MD, Ahad Sedaghat, MD, Rachna Seth, DNB MNAMS, Mariana Sgroi, MD, Ankoor S. Shah, MD, PhD, Shawkat A. Shakoor, MS, Manoj K. Sharma, MD, Sadik T. Sherief, MD, Carol L. Shields, MD, David Sia, MB ChB, FRANZCO, Sorath Noorani Siddiqui, MD, Sidi Sidi cheikh, MD, PhD, Sónia Silva, MD, Arun D. Singh, MD, Usha Singh, MS, Penny Singha, MD, Rita S. Sitorus, MD, PhD, Alison H. Skalet, MD, PhD, Hendrian D. Soebagjo, MD, PhD, Tetyana Sorochynska, MD, PhD, Grace Ssali, MD, Andrew W. Stacey, MD, Sandra E. Staffieri, PhD, Erin D. Stahl, MD, David M. Steinberg, PhD, David K. Stones, MBChB, FCPaed, Caron Strahlendorf, MD, Maria Estela Coleoni Suarez, MD, Sadia Sultana, FCPS, Xiantao Sun, MD, Rosanne Superstein, MD, Eddy Supriyadi, MD, PhD, Supawan Surukrattanaskul, MD, Shigenobu Suzuki, MD, PhD, Karel Svojgr, MD, PhD, Fatoumata Sylla, MD, Gevorg Tamamyan, MD, PhD, Deborah Tan, MBBS, Alketa Tandili, MD, PhD, Jing Tang, MD, Fanny F. Tarrillo Leiva, MD, Maryam Tashvighi, MD, Bekim Tateshi, MD, PhD, Kok Hoi Teh, MD, Edi S. Tehuteru, MD, Luiz F. Teixeira, MD, Manca Tekavcic Pompe, MD, PhD, Abdullah Dahan M. Thawaba, MD, Tuyisabe Theophile, MSc, Helen Toledano, MBChB, Doan L. Trang, MD, Fousseyni Traoré, MD, Devjyoti Tripathy, MD, Samuray Tuncer, MD, Harba Tyau-Tyau, MD, Ali B. Umar, MD, FMCPath, Emel Unal, MD, Ogul E. Uner, BA, Steen F. Urbak, MD, PhD, Tatiana L. Ushakova, MD, Rustam H. Usmanov, MD, Sandra Valeina, MD, Paola Valente, MD, Milo van Hoefen Wijsard, MD, Jacqueline Karina Vasquez Anchaya, MD, Leon O. Vaughan, FRCS (Ed), Nevyana V. Veleva-Krasteva, MD, PhD, Nishant Verma, MD, Andi A. Victor, MD, PhD, Maris Viksnins, MD, Edwin G. Villacís Chafla, MD, Victor M. Villegas, MD, Victoria Vishnevskia-Dai, MD, Keith Waddell, DM, FRCP, FRCS, FRCOphth, Amina H. Wali, MD, FMCOph Nigeria, Yi-Zhuo Wang, MD, Nutsuchar Wangtiraumnuay, MD, FICO, Julie A. Wetter, MMed Rad Onc, FCRad Onc, Widiarti P. Riono, MD, Matthew W. Wilson, MD, Amelia D.C. Wime, MD, Atchareeya Wiwatwongwana, MD, Damrong Wiwatwongwana, MD, Charlotte Wolley Dod, MD, Emily S. Wong, FCOphth HK, FHKAM, Phanthipha Wongwai, MD, PhD, Si-qi Wu, MSc, Daoman Xiang, MD, PhD, Yishuang Xiao, MSc, Bing Xu, MD, Kang Xue, MD, Antonio Yaghy, MD, Jason C. Yam, FRCSEd, Huasheng Yang, MD, Jenny M. Yanga, MD, Muhammad A. Yaqub, MD, FCPS, FRCSEd, Vera A. Yarovaya, MD, Andrey A. Yarovoy, MD, PhD, Huijing Ye, MD, Roberto I. Yee, MD, Yacoub A. Yousef, MD, Putu Yuliawati, MD, Arturo M. López, MD, Ekhtelbenina Zein, MD, Yi Zhang, MD, PhD, Katsiaryna Zhilyaeva, MD, Nida Zia, MBBS, MCPS, Othman A.O. Ziko, MD, PhD, Marcia Zondervan, MBA, Sabrina Schlüter, MD, and Richard Bowman, FRCOphth

Subjects
External beam radiotherapy, Extraocular extension, Multimodal treatment, Retinoblastoma, Tumor, Ophthalmology, RE1-994
Abstract

Purpose: To study the treatment and outcomes of children with retinoblastoma (RB) with extraocular tumor extension (RB-EOE) and compare them with RB without extraocular tumor extension (RB-w/o-EOE). Design: Multicenter intercontinental collaborative prospective study from 2017 to 2020. RB-EOE cases included those with overt orbital tumor extension in treatment-naive patients. Cases with microscopic orbital extension detected postenucleation were excluded from the study. Participants: A total of 319 children with RB-EOE and 3116 children with RB-w/o-EOE. Intervention: Chemotherapy, enucleation, exenteration, radiotherapy. Main Outcome Measures: Systemic metastasis and death. Results: Of the 3435 RB patients included in this study, 309 (9%) were from low-income countries (LIC), 1448 (42%) from lower-middle income, 1012 (29%) from upper-middle income, and 666 (19%) patients from high-income countries. There was an inverse relationship between the percentage of RB-EOE and national income level, with 96 (31%) patients from LIC, 197 (6%) lower-middle income, 20 (2%) upper-middle income, and 6 (1%) patients from high-income countries (P = 0.0001). The outcomes were statistically significant for RB-EOE compared with RB-w/o-EOE: systemic metastasis (32% vs. 4% respectively; P = 0.0001) and metastasis-related death (63% vs. 6% respectively; P = 0.0001). Multimodal treatment was the most common form of treatment (n = 177; 54%) for RB-EOE, with most cases undergoing a combination of intravenous chemotherapy and enucleation (n = 97; 30%). Adjuvant external beam radiotherapy (EBRT) after surgery (enucleation/orbital exenteration) was given in only 68 (21%) cases. Kaplan–Meier analysis for systemic metastasis and metastasis-related death in RB-EOE was 28% and 57% at 1 year, 29% and 60% at 2 years, and 29% and 61% at 3 years, respectively. Cox regression analysis revealed that the risk of death from RB-EOE was greater in patients aged >4 years than

Published
2025
Full Text
View/download PDF

2. Iris melanoma presenting as childhood glaucoma

Author

Briana C. Gapsis, Nichelle A. Warren, Matthew J. Nutaitis, Leah A. Bonaparte, Samuel L. Cooper, Michael Ashenafi, Hans E. Grossniklaus, and George N. Magrath

Subjects
Ophthalmology, RE1-994
Abstract

Purpose: To describe the natural history and management of a rare case of iris melanoma in a pediatric patient. Observations: A Caucasian female presented with left pupillary abnormalities at age 7, progressive iris changes at age 9, and markedly elevated intraocular pressure with advanced optic nerve cupping at 11 years of age. She was found to have a pigmented lesion overlying her iris and invading her angle. Trans-corneal fine needle aspirate biopsy demonstrated malignant melanoma of the iris. The patient subsequently underwent Iodine-125 plaque brachytherapy for the tumor. Conclusions: and Importance: Early identification and treatment of iris melanoma may be associated with decreased risk of local progression and metastatic disease. Treatment of glaucoma in conjunction with uveal melanoma is complicated by tumor specific considerations, including treatment of the tumor and prevention of metastasis. Keywords: Iris melanoma, Glaucoma, Pediatric

Published
2018
Full Text
View/download PDF

3. The Safety and Biological Activity of OTT166, a Novel Topical Selective Integrin Inhibitor for the Treatment of Diabetic Eye Disease: A Phase 1b Study

Author

David S. Boyer, Peter K. Kaiser, George N. Magrath, Kerrie Brady, Scott Edwards, David J. Tanzer, and Jeffrey S. Heier

Subjects
Integrins, Diabetic Retinopathy, Humans, Prospective Studies, Ophthalmic Solutions, Macular Edema
Abstract

BACKGROUND AND OBJECTIVES: To evaluate the safety, tolerability, and biological activity of a topical selective integrin inhibitor (OTT166) eyedrop administered BID for diabetic retinopathy (DR) and diabetic macular edema (DME). STUDY DESIGN/MATERIALS AND METHODS: A prospective, multicenter, randomized, double-masked Phase 1b study. Subjects with nonproliferative DR and DME with central subfield thickness (CST) > 325 microns were randomized to OTT166 eyedrops (2.5% or 5%) BID for 28 days. Subjects were followed for an additional 28 days after treatment cessation. RESULTS: Forty-four subjects were enrolled. No drug-related serious adverse events (SAEs) and two drug-related adverse events (AEs) were reported. OTT166 was well-tolerated with no evidence of ocular toxicity. Best-corrected visual acuity (BCVA) remained stable. Mean central retinal thickness (CRT) overall was variable: +12.8/+1.8 microns at Day 28 (end of treatment) and −50.3/+5.5 microns at Day 56 (end of study) for the 2.5% and 5% groups, respectively. Median CRT overall demonstrated consistent reduction by end of study: −39.0/−16.5 microns for the 2.5% and 5% groups, respectively. Median responses were greater in the treatment-naïve group (−41.5/−26.0 microns for the 2.5% and 5% groups, respectively). Thirty-seven percent of ‘responder’ subjects exhibited a mean reduction in CRT of 46.6 microns on optical coherence tomography (OCT) at end of treatment (Day 28) which persisted to end of the study (Day 56) – mean reduction of 67.4 microns, suggesting a durable effect. CONCLUSION: OTT166 eyedrops were safe, well-tolerated, and demonstrated biological activity in 37% of responders. These results warrant further evaluation of OTT166 eyedrops. [ Ophthalmic Surg Lasers Imaging Retina 2022;53:553–560.]

Published
2022

5. A multicentre, randomized, double‐masked, parallel group, vehicle‐controlled phase IIb study to evaluate the safety and efficacy of 1% and 3% topical minocycline gel in patients with papulopustular rosacea†

Author

Guy F. Webster, Sunil Dhawan, M. Lee, George N. Magrath, Zoe Diana Draelos, Mohammad Salman, and Emmy Graber

Subjects
medicine.medical_specialty, Minocycline, Dermatology, Administration, Cutaneous, Gastroenterology, Lesion, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Internal medicine, medicine, Clinical endpoint, Humans, Papulopustular rosacea, In patient, Prospective Studies, business.industry, Odds ratio, Original Articles, medicine.disease, Clinical Trial, United States, Confidence interval, Treatment Outcome, Rosacea, Dermatologic Agents, medicine.symptom, business, medicine.drug
Abstract

Summary Background Papulopustular rosacea is characterized by chronic facial erythema and inflammatory facial lesions. Minocycline has anti‐inflammatory properties which may be effective in the treatment of rosacea inflammatory lesions. Objectives To assess the safety and efficacy of once‐daily topical minocycline gel 1% and 3% in patients with papulopustular rosacea. Methods This was a prospective, 12‐week, double‐blinded study conducted at 26 sites in the United States; 270 patients with papulopustular rosacea and 12–40 inflammatory lesions were randomized to minocycline 1%, minocycline 3% or vehicle. The primary endpoint was the mean change in inflammatory lesions at week 12. Key secondary endpoints included success on an Investigator's Global Assessment (IGA). Results Baseline mean lesion counts were 24·6, 25·1 and 24·3 in the minocycline 1%, minocycline 3% and vehicle groups, respectively; at week 12, the counts had decreased by 12·6, 13·1 and 7·9, respectively. Minocycline significantly decreased lesions, compared with the vehicle [P = 0·01, 95% confidence interval (CI) 7·9 to 0·9, for minocycline 1%; P = 0·007, 95% CI 8·3 to 1·3, for minocycline 3%]. The proportion of patients achieving IGA success was 39% in the minocycline 1% arm [P = 0·34, odds ratio (OR) 1·396 and OR 95% CI 0·71 to 2·75 vs. vehicle], 46% in the minocycline 3% arm (P = 0·04, OR 2·03 and OR 95% CI 1·04 to 3·95 vs. vehicle) and 31% in the vehicle arm. Conclusions Minocycline topical gel appears to be safe and tolerable at concentrations of 1% and 3%, and both concentrations significantly decreased inflammatory lesion counts, with a significantly larger proportion of patients achieving IGA success at week 12 in the minocycline 3% arm. These findings support further evaluation of minocycline gel for treating inflammatory lesions associated with papulopustular rosacea. Linked Comment: Hampton. Br J Dermatol 2020; 183:412–413., What is already known about this topic? Papulopustular rosacea is characterized by inflammatory facial lesions and chronic erythema of the face.Oral minocycline has been reported to have efficacy in the treatment of inflammatory lesions of papulopustular rosacea. What does this study add? The study shows that a topical gel preparation of minocycline significantly decreased the number of inflammatory lesions and significantly improved the Investigator's Global Assessment score in patients with papulopustular rosacea.This may offer a topical therapeutic alternative to oral doxycycline or oral minocycline for the treatment of inflammatory lesions in papulopustular rosacea, with potentially fewer systemic side‐effects, owing to lower systemic drug exposure. Linked Comment: Hampton. Br J Dermatol 2020; 183:412–413. Plain language summary available online

Published
2020

6. Inherited Retinal Dystrophy in Southeastern United States: Characterization of South Carolina Patients and Comparative Literature Review

Author

Joseph Griffith, Kareem Sioufi, Laurie Wilbanks, George N. Magrath, Emil A. T. Say, Michael J. Lyons, Meg Wilkes, Gurpur Shashidhar Pai, and Mae Millicent Winfrey Peterseim

Subjects
Membrane Glycoproteins, South Carolina, Cell Cycle Proteins, retinal dystrophy, retinitis pigmentosa, Stargardt disease, Usher syndrome, Southeastern United States, Cytoskeletal Proteins, Review Literature as Topic, Antigens, Neoplasm, Retinal Dystrophies, Genetics, Humans, ATP-Binding Cassette Transporters, Usher Syndromes, Retinitis Pigmentosa, Genetics (clinical), Molecular Chaperones, Retrospective Studies
Abstract

Inherited retinal dystrophies (IRDs) are a group of rare diseases involving more than 340 genes and a variety of clinical phenotypes that lead to significant visual impairment. The aim of this study is to evaluate the rates and genetic characteristics of IRDs in the southeastern region of the United States (US). A retrospective chart review was performed on 325 patients with a clinical diagnosis of retinal dystrophy. Data including presenting symptoms, visual acuity, retinal exam findings, imaging findings, and genetic test results were compiled and compared to national and international IRD cohorts. The known ethnic groups included White (64%), African American or Black (30%), Hispanic (3%), and Asian (2%). The most prevalent dystrophies identified clinically were non-syndromic retinitis pigmentosa (29.8%), Stargardt disease (8.3%), Usher syndrome (8.3%), cone-rod dystrophy (8.0%), cone dystrophy (4.9%), and Leber congenital amaurosis (4.3%). Of the 101 patients (31.1%) with genetic testing, 54 (53.5%) had causative genetic variants identified. The most common pathogenic genetic variants were USH2A (n = 11), ABCA4 (n = 8), CLN3 (n = 7), and CEP290 (n = 3). Our study provides initial information characterizing IRDs within the diverse population of the southeastern US, which differs from national and international genetic and diagnostic trends with a relatively high proportion of retinitis pigmentosa in our African American or Black population and a relatively high frequency of USH2A pathogenic variants.

Published
2022
Full Text
View/download PDF

7. Corneal melt in conjunctival intraepithelial neoplasia

Author

Jorge Haddad, George N. Magrath, Nichelle A. Warren, Karolinne Maia Rocha, and Ryan N. Mercer

Subjects
medicine.medical_specialty, medicine.medical_treatment, Conjunctival intraepithelial neoplasia, Alpha interferon, Glaucoma, Cryotherapy, Case Report, Ocular surface squamous neoplasia, 03 medical and health sciences, 0302 clinical medicine, lcsh:Ophthalmology, Corneal thinning, Ophthalmology, Cornea, Biopsy, medicine, medicine.diagnostic_test, business.industry, Carcinoma in situ, Corneal melt, medicine.disease, eye diseases, medicine.anatomical_structure, lcsh:RE1-994, Corneal neovascularization, 030221 ophthalmology & optometry, Punctate epithelial erosions, sense organs, Interferon alpha 2b, business, 030217 neurology & neurosurgery
Abstract

Purpose Report a case of corneal melt in a patient with conjunctival intraepithelial neoplasia (CIN) treated with topical interferon (IFN) alpha-2B. Observations An 89-year-old man presented with gelatinous paralimbal lesions of the left eye extending onto the cornea with corneal neovascularization extending 5–6 clock hours. Nasally there was mild absence of the terminal vascular loops of the limbal palisades of Vogt and conjunctivalization. Diffuse punctate epithelial erosions were noted. The corneal graft displayed subepithelial and stromal edema. Anterior segment optical coherence tomography detected hyperreflectivity, sectional thickened epithelium, and abrupt transitions from normal to abnormal tissue. The patient was treated with excision of the corneal and conjunctival lesions with cryotherapy to the conjunctival borders. Excisional biopsy revealed CIN Grade 3 and carcinoma in situ of the cornea. Topical IFN alpha-2B four times daily was initiated postoperatively. Two months later, a central epithelial defect developed. The cornea progressively thinned and corneal melt ensued. The patient had several risk factors for corneal melt including neurotrophic cornea, early limbal stem cell deficiency, history of cryotherapy, keratoconjunctivitis sicca, and chronic use of glaucoma medications and steroid medications. Conclusions Interferon alpha-2B is an effective first line treatment for CIN with few side effects. It's side effects include punctate epithelial erosions, conjunctival hyperemia, and follicular conjunctivitis. We report a case of pre-existing keratoconjunctivitis sicca, early limbal stem cell deficiency, neurotrophic cornea, and newly diagnosed CIN Grade 3; it was treated with surgical excision, cryotherapy, and topical IFN alpha-2b with development of corneal melt 2 months later. Caution should be taken when using interferon alpha -2b in patients with pre-existing keratoconjunctivitis sicca, neurotrophic cornea, or limbal stem cell deficiency as it could exacerbate these conditions resulting in corneal melt.

Published
2020

8. Iris melanoma presenting as childhood glaucoma

Author

Matthew J. Nutaitis, Nichelle A. Warren, George N. Magrath, Briana C. Gapsis, Leah A. Bonaparte, M Ashenafi, Hans E. Grossniklaus, and Samuel Lewis Cooper

Subjects
medicine.medical_specialty, genetic structures, Glaucoma, Disease, urologic and male genital diseases, Metastasis, 03 medical and health sciences, 0302 clinical medicine, lcsh:Ophthalmology, Ophthalmology, Biopsy, Case report, medicine, Iris (anatomy), Iris melanoma, Pediatric, medicine.diagnostic_test, business.industry, urogenital system, Melanoma, medicine.disease, eye diseases, Natural history, medicine.anatomical_structure, lcsh:RE1-994, 030221 ophthalmology & optometry, sense organs, business, 030217 neurology & neurosurgery
Abstract

Purpose: To describe the natural history and management of a rare case of iris melanoma in a pediatric patient. Observations: A Caucasian female presented with left pupillary abnormalities at age 7, progressive iris changes at age 9, and markedly elevated intraocular pressure with advanced optic nerve cupping at 11 years of age. She was found to have a pigmented lesion overlying her iris and invading her angle. Trans-corneal fine needle aspirate biopsy demonstrated malignant melanoma of the iris. The patient subsequently underwent Iodine-125 plaque brachytherapy for the tumor. Conclusions: and Importance: Early identification and treatment of iris melanoma may be associated with decreased risk of local progression and metastatic disease. Treatment of glaucoma in conjunction with uveal melanoma is complicated by tumor specific considerations, including treatment of the tumor and prevention of metastasis. Keywords: Iris melanoma, Glaucoma, Pediatric

Published
2018

9. Rapid anterior capsule contraction after femtosecond laser–assisted cataract surgery in a patient with retinitis pigmentosa

Author

Lynn J. Poole Perry, William J. Johnson, and George N. Magrath

Subjects
medicine.medical_specialty, 050402 sociology, genetic structures, business.industry, medicine.medical_treatment, 05 social sciences, Phacoemulsification, Cataract surgery, Anterior capsule contraction, medicine.disease, Laser assisted, eye diseases, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, 0504 sociology, Retinitis pigmentosa, 030221 ophthalmology & optometry, medicine, Capsulotomy, Surgery, sense organs, business, Capsulorhexis
Abstract

We report a case of rapid and extreme capsule contraction after uneventful femtosecond laser–assisted cataract surgery (FLACS) in one eye performed subsequent to uneventful standard phacoemulsification with manual continuous curvilinear capsulorhexis (CCC) creation in the fellow eye. In the setting of retinitis pigmentosa, the rapid and extreme anterior capsule contraction in the FLACS eye compared with the manual CCC eye might have been the result of release of inflammatory mediators from cell death during the laser capsulotomy combined with a structurally weaker CCC edge.

Published
2019
Full Text
View/download PDF

10. IMAGE QUALITY AND ARTIFACTS ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Author

George N. Magrath, Chloe T.L. Khoo, Emil Anthony T. Say, Wasim A. Samara, Sandor R. Ferenczy, and Carol L. Shields

Subjects
Adult, Male, Uveal Neoplasms, 0301 basic medicine, Choroidal melanoma, medicine.medical_specialty, Adolescent, genetic structures, Image quality, medicine.medical_treatment, Brachytherapy, Uveal Neoplasm, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Fluorescein Angiography, Child, Melanoma, Aged, Aged, 80 and over, medicine.diagnostic_test, Plaque radiotherapy, business.industry, Choroid Neoplasms, Optical Imaging, General Medicine, Optical coherence tomography angiography, Middle Aged, Fluorescein angiography, eye diseases, Ophthalmology, 030104 developmental biology, Multivariate Analysis, 030221 ophthalmology & optometry, Female, sense organs, Radiology, Tomography, Artifacts, business, Tomography, Optical Coherence
Abstract

To study image quality and artifacts seen on optical coherence tomography angiography (OCTA).Sixty-five consecutive patients with unilateral posterior uveal melanoma treated with plaque radiotherapy had OCTA during follow-up. Optical coherence tomography angiography was performed on both the affected and fellow eye. Signal strength and frequency of image artifacts on en face images were compared between affected and fellow eyes.A total of 130 eyes in 65 patients were analyzed, the mean age at time of OCTA was 55 years (median: 56, range: 12-81 years), and 39 (39/65, 60%) were female. Majority of tumors were located in the choroid (62/65, 95%) and extramacular (55/65, 85%). The mean distance to the foveola was 4 mm (median: 3, range: 0-18 mm) and optic nerve was 4 mm (median: 4, range: 0-16 mm). Optical coherence tomography angiography was performed at a mean 46 months after plaque radiotherapy. Most patients had a history of radiation maculopathy or papillopathy in the treated eye at the time of OCTA (46/65, 71%). Overall, 95 eyes (95/130, 73%) had at least one significant artifact on OCTA. The most common major artifacts were loss of focus (71/130, 55%), broad (5 pixels width and4 lines) blink lines (48/130, 37%), motion artifact (34/130, 26%), specular dot (33/130, 25%), and edge duplication (10/130, 8%). Statistically, eyes treated with plaque radiotherapy (affected vs. fellow eye) were more likely to have at least one major OCTA artifact (92 vs. 54%, P0.001) and, specifically, loss of focus was more frequent (78 vs. 31%, P0.001). Multivariate analysis found decreased visual acuity significantly associated with higher incidence of broad blink lines (P = 0.0166) and loss of signal (P0.0001), whereas male sex was associated with increased loss of signal (P = 0.0015), and distance to the foveola was related to edge duplication (P = 0.0119).Image artifacts on OCTA are commonly encountered and appear to be more frequent in eyes with pathology and poor visual acuity. Recognition of these artifacts might help improve image interpretation and decision making.

Published
2017
Full Text
View/download PDF

12. PARAFOVEAL CAPILLARY DENSITY AFTER PLAQUE RADIOTHERAPY FOR CHOROIDAL MELANOMA

Author

Chloe T.L. Khoo, Sandor R. Ferenczy, Emil Anthony T. Say, George N. Magrath, Wasim A. Samara, Priya Sharma, and Carol L. Shields

Subjects
Male, 0301 basic medicine, Choroidal melanoma, Fovea Centralis, medicine.medical_specialty, medicine.medical_treatment, Brachytherapy, Visual Acuity, Retina, 03 medical and health sciences, 0302 clinical medicine, Optics, Retinal Diseases, Ophthalmology, Humans, Medicine, Fluorescein Angiography, Radiation Injuries, Melanoma, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Plaque radiotherapy, Choroid Neoplasms, Subretinal Fluid, Radiotherapy Dosage, General Medicine, Optical coherence tomography angiography, Middle Aged, Fluorescein angiography, medicine.disease, eye diseases, Capillaries, 030104 developmental biology, Capillary density, 030221 ophthalmology & optometry, Maculopathy, Female, sense organs, Tomography, business, Tomography, Optical Coherence
Abstract

To study the parafoveal capillary density using optical coherence tomography angiography (OCTA) in eyes treated with plaque radiotherapy.Retrospective comparative case series.Ten patients treated with plaque radiotherapy for choroidal melanoma without evident radiation maculopathy on ophthalmoscopy or optical coherence tomography were imaged with OCTA.Comparison of the parafoveal capillary density in the superficial and deep capillary plexuses in the irradiated versus fellow nonirradiated eye.Overall, mean patient age was 55 years (median: 57, range: 45-65 years), and majority were white (9/10, 90%) and female (9/10, 90%). No patient had diabetes mellitus, and 2 (2/10, 20%) had controlled systemic hypertension. The melanoma was located in the choroid in all patients (10/10, 100%), with 2 (2/10, 20%) in the macular region. The mean largest basal diameter was 11 mm (12, 6-16 mm), and mean thickness was 5 mm (5, 2-10 mm). Mean radiation dose to the tumor apex was 72 Gy (median: 70 Gy, range: 70-85 Gy). Mean foveolar radiation dose was 53 Gy (median: 35 Gy, range: 14-110 Gy). Mean follow-up duration after plaque radiotherapy was 17 months (median: 16 months, range: 5-39 months). There was no ophthalmoscopic evidence of radiation maculopathy throughout the follow-up in every case. Optical coherence tomography demonstrated normal foveal contour without edema or subretinal fluid in every case. On OCTA, there was no significant difference in signal strength (P = 0.1151), central macular thickness (P = 0.9316), and foveal avascular zone area in the superficial (P = 0.1595), and deep (P = 0.1534) capillary plexuses between the irradiated versus fellow eyes. However, there was a statistically significant decrease in capillary density in the parafoveal superficial (P = 0.0005) and deep (P = 0.0067) plexuses in the irradiated eye. In addition, mean logMAR visual acuity was 0.2 (0.1, 0.0-0.5) (Snellen equivalent 20/32) in the irradiated eye and 0.0 (0.0, range: 0.0-0.1) (Snellen equivalent 20/20) in the fellow eye (P = 0.0252).Optical coherence tomography angiography allows qualitative and quantitative analysis of parafoveal capillary density. After plaque radiotherapy for choroidal melanoma, in eyes with normal macular features on ophthalmoscopy and optical coherence tomography, there is a statistically significant decrease in parafoveal capillary density and logMAR visual acuity in irradiated eyes compared with fellow eyes. These subclinical ischemic findings represent the commencement of radiation maculopathy.

Published
2016
Full Text
View/download PDF

13. CORRELATION OF FOVEAL AVASCULAR ZONE SIZE WITH FOVEAL MORPHOLOGY IN NORMAL EYES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Author

Timothy Patrick Higgins, Sandor R. Ferenczy, Emil Anthony T. Say, Chloe T.L. Khoo, Carol L. Shields, Wasim A. Samara, and George N. Magrath

Subjects
Adult, Male, Fovea Centralis, medicine.medical_specialty, Adolescent, genetic structures, Optics, Optical coherence tomography, Foveal, Ophthalmology, Healthy volunteers, medicine, Humans, Prospective Studies, Fluorescein Angiography, Child, Aged, medicine.diagnostic_test, business.industry, Healthy subjects, Retinal Vessels, General Medicine, Optical coherence tomography angiography, Foveal avascular zone, Middle Aged, Fluorescein angiography, Healthy Volunteers, eye diseases, Female, sense organs, Tomography, business, Tomography, Optical Coherence
Abstract

To analyze the foveal avascular zone (FAZ) in normal eyes using optical coherence tomography angiography.Prospective noncomparative case series. The parafoveal region of 70 eyes from 67 healthy subjects was imaged using optical coherence tomography angiography to visualize the superficial and deep capillary plexuses and correlated with standard macular volume scans using spectral domain optical coherence tomography to determine foveal morphology.In all 70 eyes imaged, 2 vascular plexuses could be detected within the retina: a superficial plexus within the ganglion cell layer and a deep plexus within the inner nuclear layer. A measurable FAZ was visualized in both plexuses in all imaged eyes. The FAZ area was variable in the study population with a mean of 0.266 mm² ± 0.097 mm² in the superficial plexus (range: 0.071 mm²-0.527 mm²) and a mean of 0.495 mm² ± 0.227 mm² in the deep plexus (range: 0.160 mm²-0.795 mm²). The FAZ area was significantly larger in the deep plexus (P0.0001) compared with superficial plexus. The FAZ area in both plexuses correlated inversely with central macular thickness and central macular volume (P0.0001). No significant correlation was found between superficial plexus FAZ area and age (P = 0.55) or sex (P = 0.34). In the same manner, no significant correlation was found between deep plexus FAZ area and age (P = 0.13) or sex (P = 0.13).Optical coherence tomography angiography provides a noninvasive method to visualize and measure the superficial and deep plexus FAZ in a normal population. The FAZ can vary in size and shape, with the FAZ area significantly larger in the deep compared with the superficial plexus. Both superficial and deep FAZ area correlate inversely with foveal thickness and volume.

Published
2015
Full Text
View/download PDF

14. Detection of Minimally Visible Recurrent Retinoblastoma by Hand-held Spectral-Domain Optical Coherence Tomography

Author

Maria E Gonzalez-Montpetit, George N. Magrath, Wasim A. Samara, and Carol L. Shields

Subjects
Male, medicine.medical_specialty, genetic structures, Retinal Neoplasms, Spectral domain, Recurrent retinoblastoma, Retina, 03 medical and health sciences, 0302 clinical medicine, Optics, Optical coherence tomography, Adjuvant therapy, medicine, Humans, Strabismus, Subclinical infection, medicine.diagnostic_test, business.industry, Hand held, Retinoblastoma, Infant, Equipment Design, General Medicine, eye diseases, Ophthalmology, medicine.anatomical_structure, Fundus (uterus), Pediatrics, Perinatology and Child Health, 030221 ophthalmology & optometry, Female, sense organs, Radiology, Neoplasm Recurrence, Local, business, Tomography, Optical Coherence, 030217 neurology & neurosurgery
Abstract

A 2-month-old male infant with bilateral familial retinoblastoma was treated with intravenous chemotherapy and focal adjuvant therapy. At 5 months of follow-up, fundus examination and ultrasonography disclosed no recurrence; however, hand-held spectral-domain optical coherence tomography (SD-OCT) demonstrated subclinical recurrence within a previous regression scar. Subsequent treatment led to flat scar. Hand-held SD-OCT can be a useful tool for detection of subclinical recurrent retinoblastoma. [ J Pediatr Ophthalmol Strabismus . 2017;54:e6–e8.]

Published
2017
Full Text
View/download PDF

15. VARIABILITY IN FOVEAL AVASCULAR ZONE AND CAPILLARY DENSITY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY MACHINES IN HEALTHY EYES

Author

George N. Magrath, Emil Anthony T. Say, Wasim A. Samara, Sandor R. Ferenczy, Carol L. Shields, and Kareem Sioufi

Subjects
Adult, Male, medicine.medical_specialty, Fovea Centralis, genetic structures, Fundus Oculi, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Optical coherence tomography, Healthy volunteers, medicine, Humans, Prospective Studies, Fluorescein Angiography, Plexus, medicine.diagnostic_test, business.industry, Reproducibility of Results, Retinal Vessels, General Medicine, Optical coherence tomography angiography, Foveal avascular zone, Equipment Design, Middle Aged, eye diseases, Healthy Volunteers, Surgery, Capillaries, Ophthalmology, Capillary density, 030221 ophthalmology & optometry, Cirrus, Female, Tomography, business, Nuclear medicine, 030217 neurology & neurosurgery, Tomography, Optical Coherence
Abstract

PURPOSE To evaluate the variability in foveal avascular zone (FAZ) and capillary density measurements on optical coherence tomography angiography using Optovue RTVue XR Avanti (OA) (Optovue) and Zeiss Cirrus HD-OCT 5000 (ZC) (Carl Zeiss Meditec). METHODS In this prospective, comparative case series, parafoveal (3 × 3 mm) optical coherence tomography angiography scans were obtained on healthy volunteers using both the Avanti and Cirrus. The FAZ area and capillary density at the level of both the superficial and deep capillary plexus were measured automatically using the built-in ReVue software (Optovue) with the Avanti as well as manually using ImageJ (National Institutes of Health) with both machines. RESULTS There were 50 eyes in 25 healthy volunteers included in the analysis. Mean subject age was 33 years and there were 14 women (56%). On optical coherence tomography, mean central macular thickness was significantly greater on OA (259.1 μm) than ZC (257.6 μm, P = 0.0228). On optical coherence tomography angiography, mean superficial and deep plexus FAZ measured 0.2855 mm and 0.3465 mm on Avanti automated (A-A), 0.2739 mm and 0.3637 mm on Avanti manual (A-M), and 0.2657 mm and 0.3993 mm on Cirrus manual (C-M), respectively. There were no statistically significant differences in superficial plexus FAZ measurements between the A-A and A-M (P = 0.4019) or A-A and C-M (P = 0.1336). The A-M measured significantly larger than C-M (P = 0.0396). Deep plexus FAZ measurements were similar on A-A and A-M (P = 0.6299), but both were significantly less compared with C-M (P < 0.0001 for A-A vs. C-M, P = 0.0184 for A-M vs. C-M). Mean superficial and deep plexus capillary densities were 53.6% and 59.3% on A-A, 48.1% and 47.7% on A-M, and 52.5% and 48.1% on C-M, respectively. Superficial plexus capillary density measurements were statistically similar on A-A and C-M (P = 0.0623), but both were significantly higher than A-M (P < 0.0001 for A-A vs. A-M, P < 0.0001 for A-M vs. C-M). However, deep plexus capillary density measurements on A-A were significantly higher than A-M (P < 0.0001) and C-M (P < 0.0001), but A-M and C-M measurements were similar (P = 0.5986). There was no significant difference in all parameters measured in both eyes of one subject using any of the three measuring techniques. CONCLUSION While measurements taken with the same machine and technique are consistent and reliable between fellow eyes, significant variability exists in FAZ and capillary density measurements among different machines and techniques. Comparison of measurements across machines and techniques should be considered with caution.

Published
2016

16. Dissecting Aortic Aneurysm 55 Years after Diagnosis of Iris Flocculi

Author

George N. Magrath, Jerry A. Shields, Richard J. Mackool, Carol L. Shields, Ralph C. Eagle, and Hans E. Grossniklaus

Subjects
0301 basic medicine, medicine.medical_specialty, genetic structures, medicine.medical_treatment, urologic and male genital diseases, Iris flocculi, 03 medical and health sciences, 0302 clinical medicine, Ophthalmology, medicine.artery, medicine, Iris pigment epithelium, Cyst, cardiovascular diseases, Iris (anatomy), Dissecting aortic aneurysm, Case Series and Brief Reports, General Nursing, Aorta, urogenital system, business.industry, Cataract surgery, medicine.disease, eye diseases, Surgery, 030104 developmental biology, medicine.anatomical_structure, Heart failure, 030221 ophthalmology & optometry, business
Abstract

Purpose: The aim of this study is to report the clinical features, imaging studies, surgical removal, and pathology of congenital iris flocculi in a patient who developed a life-threatening dissecting aortic aneurysm after 55 years of follow-up. Methods: Documentation with iris photography was performed from age 18 to 55 years, at which time anterior segment optical coherence tomography (OCT) was performed. At the time of subsequent cataract surgery, the iris flocculi were removed in each eye and submitted for light and electron microscopy. Results: The size and shape of the iris flocculi waxed and waned over the years but caused no visual disturbance. Anterior segment OCT demonstrated clear, round cysts with thin lining and no solid component. At the age of 55, congestive heart failure from a dissecting aortic aneurysm was discovered and surgically repaired. Subsequent bilateral cataract surgery and cyst removal were performed, and the iris flocculi were studied with light and electron microscopy. Conclusions: Congenital iris flocculi cause little, if any, visual impairment in most cases. However, they are occasionally associated with dissecting aortic aneurysm due to a shared mutation in smooth muscle that affects both the iris and the aorta. Patients with iris flocculi should be monitored periodically for aortic abnormalities.

Published
2016

17. Contents Vol. 2, 2016

Author

David A. Piccoli, Camille Sabella, Christopher K.H. Burris, Kelly K. Koeller, Subramanian Krishnakumar, Jose S. Pulido, Mengensatzproduktion, Ilya M. Leyngold, Alan Kozarsky, Aline Roseane Queiroz de Paiva, William R. Munday, Angela C. Gauthier, Thomas Plesec, Gordon Hay, Derek K. Ho, Pia R. Mendoza, Murtuza Nuruddin, Arun D. Singh, Maddy Ashwin Reddy, Larissa Abreu de Azevedo Fraga, Hiroshi Goto, Ralph C. Eagle, Miguel A. Materin, Hardeep Singh Mudhar, Gena M. Damento, Unni K. Udayasankar, Richard J. Mackool, Christopher C. Teng, Jessica S Maslin, Jerry A. Shields, Steven Yeh, Druckerei Stückle, Marianne Grantham, Caroline Craven, Caroline Thaung, Vikas Khetan, Venkatesan Nalini, William V. Anninger, Shunichiro Ueda, Mina L. Xu, Alex V. Levin, George N. Magrath, Perinkulam Ravi Deepa, Hassan Aziz, Mina M. Naguib, Arjun B. Sood, Diva R. Salomao, Carol L. Shields, Edgar M. Espana, Virgínia Laura Lucas Torres, Roshni U. Ranjit, Angela Bessette, George H. Fisher, Hans E. Grossniklaus, Vasilios P. Papastefanou, Alexander T. Nguyen, Curtis E. Margo, Soma Rani Roy, Victoria M L Cohen, Rajeswari Raguraman, and Frances A. Jacinto

Subjects
Pathology, medicine.medical_specialty, business.industry, Medicine, business, General Nursing
Published
2016
Full Text
View/download PDF

18. Mini- and Maxi-peaks of Combined Hamartoma on Enhanced Depth Imaging Optical Coherence Tomography

Author

Carol L. Shields, Chloe T.L. Khoo, and George N. Magrath

Subjects
Male, medicine.medical_specialty, genetic structures, Adolescent, Hamartoma, Retinal Pigment Epithelium, Asymptomatic, Diagnosis, Differential, Optics, Optical coherence tomography, Retinal Diseases, Ophthalmology, medicine, Humans, Retina, Retinal pigment epithelium, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, Image Enhancement, eye diseases, medicine.anatomical_structure, Gliosis, Pediatrics, Perinatology and Child Health, Vitreoretinal traction, sense organs, Enhanced depth imaging, medicine.symptom, business, Tomography, Optical Coherence
Abstract

A 17-year-old asymptomatic boy with a referral diagnosis of “macular gliosis” was found to have a combined hamartoma of the retina and retinal pigment epithelium. Enhanced depth imaging optical coherence tomography showed characteristic features of mini- and maxi-peaks from vitreoretinal traction. [ J Pediatr Ophthalmol Strabismus. 2015;52:e38–e40.]

Published
2015

19. Esophageal adenocarcinoma and urothelial carcinoma orbital metastases masquerading as infection

Author

Wade A. Reardon, George N. Magrath, Andrew S. Eiseman, Charles M. Proctor, Krishna G. Patel, and Eric J. Lentsch

Subjects
Diagnostic Imaging, Male, medicine.medical_specialty, Metastatic Urothelial Carcinoma, genetic structures, Esophageal Neoplasms, Biopsy, Adenocarcinoma, Metastasis, Diagnosis, Differential, medicine, Humans, Esophagus, Sinusitis, medicine.diagnostic_test, business.industry, Palliative Care, Middle Aged, medicine.disease, eye diseases, Surgery, Ophthalmology, medicine.anatomical_structure, Urinary Bladder Neoplasms, Superior orbital fissure, Orbital Neoplasms, Female, sense organs, Radiology, Orbital cellulitis, business
Abstract

Orbital metastases can masquerade as other orbital processes. We present two cases of orbital metastases, the first being the first reported adenocarcinoma of the esophagus presenting as an orbital metastasis prior to the primary being known, and the other as the first urothelial carcinoma to present as orbital cellulitis. The first patient presented with left upper eyelid pain. CT scan identified a superolateral subperiosteal fluid collection without concomitant sinus disease, which was drained in the operating room. Two weeks later repeat CT scan showed recurrent orbital subperiosteal fluid. It was drained and a biopsy showed necrotic adenocarcinoma. The second case presented with a painless right proptosis, decreased vision, and globally decreased ocular motility 3 days after bladder resection for urothelial carcinoma. CT scan demonstrated pan sinusitis with a soft tissue mass in the apex of the right orbit with extension through the superior orbital fissure. After no improvement on antibiotics endoscopic drainage was performed. Pathology revealed metastatic urothelial carcinoma within the orbital fat.

Published
2014

20. Dynamic MRI of an orbital varix

Author

Hugh E. Wright, Charles M. Proctor, and George N. Magrath

Subjects
Male, medicine.medical_specialty, Incidental Findings, medicine.diagnostic_test, business.industry, Valsalva Maneuver, medicine.medical_treatment, Accidents, Traffic, Magnetic resonance imaging, General Medicine, Middle Aged, Magnetic Resonance Imaging, Varicose Veins, Ophthalmology, Orbital varix, Dynamic contrast-enhanced MRI, Valsalva maneuver, medicine, Humans, Surgery, Radiology, business, Orbit
Published
2014

21. Flat choroidal melanoma masquerading as central serous chorioretinopathy

Author

George N. Magrath, Chloe T.L. Khoo, Carol L. Shields, and Timothy Patrick Higgins

Subjects
0301 basic medicine, retina, medicine.medical_specialty, Visual acuity, genetic structures, Central serous chorioretinopathy, Case Report, Lesion, 03 medical and health sciences, 0302 clinical medicine, lcsh:Ophthalmology, Blurred vision, Ophthalmology, melanoma, medicine, Retina, optical coherence tomography, business.industry, Melanoma, medicine.disease, eye diseases, Choroidal nevus, Serous fluid, 030104 developmental biology, medicine.anatomical_structure, lcsh:RE1-994, 030221 ophthalmology & optometry, sense organs, Choroid, medicine.symptom, business, choroid
Abstract

There are several mimickers of choroidal melanoma. We report a patient with recent family stress who developed blurred vision to 20/50 OD and was found to have unilateral central serous chorioretinopathy and a coincidental choroidal nevus. After 1 year without resolution of the subretinal fluid, the patient was referred for our opinion. On examination, visual acuity was 20/50 in the right eye and 20/20 in the left eye. The left eye was normal. Evaluation of the right eye showed a small, pigmented submacular choroidal lesion measuring 4 mm Χ 3 mm. Ultrasonography documented an isoechoic mass measuring 1.71 mm in thickness. Optical coherence tomography showed subretinal fluid with shaggy photoreceptors and hyper-reflective material within the subretinal fluid, likely indicative of lipofuscin within macrophages. Autofluorescence revealed orange pigment overlying the lesion. These features were strongly suggestive of small choroidal melanoma with five risk factors for tumor growth. Treatment with Iodine-125 plaque brachytherapy was performed on the patient. The readers should keep in mind that choroidal melanoma can manifest as a tiny choroidal mass with related multimodal imaging features of subretinal fluid and orange pigment.

Published
2016
Full Text
View/download PDF

23. Orbital cellulitis complicated by central retinal artery occlusion

Author

John H. Johnson, Ronald G. Teed, Charles M. Proctor, George N. Magrath, and Luis E. Fernández de Castro

Subjects
Male, medicine.medical_specialty, Intraocular pressure, Visual acuity, genetic structures, Adolescent, Retinal Artery Occlusion, Vision Disorders, Visual Acuity, Eye Infections, Bacterial, Ischemia, medicine, Humans, Fluorescein Angiography, Intraocular Pressure, medicine.diagnostic_test, business.industry, Retinal Vessels, General Medicine, Eye infection, Orbital Cellulitis, medicine.disease, Fluorescein angiography, Decompression, Surgical, Arcanobacterium, Combined Modality Therapy, eye diseases, Surgery, Anti-Bacterial Agents, Ophthalmology, Central retinal artery occlusion, Examination Under Anesthesia, Drug Therapy, Combination, sense organs, medicine.symptom, Orbital cellulitis, Complication, business, Actinomycetales Infections
Abstract

The authors present a case of a 16-year-old boy who sought treatment in Storm Eye Institute for orbital cellulitis complicated by central retinal artery occlusion. He was examined for severe signs of orbital cellulitis, including decreased vision and an afferent pupillary defect. Intravenous antibiotics failed to provide timely improvement, and the patient was surgically managed with endoscopic orbital decompression. An ocular examination under anesthesia revealed retinal ischemia in the affected eye, and fluorescein angiography confirmed the diagnosis of central retinal artery occlusion. The patient's vision improved slightly following resolution of the infection. Central retinal artery occlusion is a rare complication of orbital cellulitis in adults and has yet to be reported in the pediatric population.

Published
2012

24. Predictive value of the efficacy of glaucoma medications in animal models: preclinical to regulatory studies

Author

George N. Magrath, Christina M. Demos, Jeanette A. Stewart, Lindsay A. Nelson, and William C. Stewart

Subjects
medicine.medical_specialty, MEDLINE, Drug Evaluation, Preclinical, Glaucoma, Pharmacology, Cellular and Molecular Neuroscience, Medicine, Animals, Humans, Adverse effect, Intensive care medicine, Drug Approval, Antihypertensive Agents, Clinical Trials as Topic, business.industry, medicine.disease, Predictive value, Sensory Systems, Review article, Clinical trial, Ophthalmology, Disease Models, Animal, Treatment Outcome, New product development, Drug and Narcotic Control, Animal studies, business
Abstract

To gain regulatory approval for a new medicine, a pharmaceutical company must take the new product through a series of clinical trials (Phases I-III). Animal models are important in the new drug-development process because they allow for the testing of the efficacy and safety of potential new medicines in a cost-efficient manner that avoids the risk of serious adverse events to humans. Unfortunately, there is no perfect animal treatment model for glaucoma. Animal studies hopefully predict the results of clinical studies, but with estimating efficacy, the limited size and duration of these studies, as well as the animal model selection, might restrict the ability to accurately predict future results. There is little information which compares various available animal models and how well these preclinical studies predict the efficacy of a new product in clinical trials. The purpose of this review article is to analyse animal model studies evaluating potential glaucoma products and determine parameters associated with commercial availability. We discuss how animal models provide some success in predicting commercial launch of a new glaucoma medicine, especially the hypertensive and monkey models, but highlight that caution must be used in interpreting individual models or studies.

Published
2010

25. Cystoid macular edema secondary to fluconazole toxicity

Author

John W. Wilson, Craig M. Mason, Jose S. Pulido, Javier Montero, and George N. Magrath

Subjects
medicine.medical_specialty, Antifungal Agents, Coccidioides immitis, Fundus Oculi, Administration, Oral, Drug Administration Schedule, Macular Edema, Edema, medicine, Immunology and Allergy, Humans, Fluorescein Angiography, Macular edema, Fluconazole, Aged, Voriconazole, Coccidioidomycosis, biology, Dose-Response Relationship, Drug, business.industry, Triazoles, biology.organism_classification, medicine.disease, Rash, Dermatology, Ophthalmology, Pyrimidines, Treatment Outcome, Anesthesia, Toxicity, Retreatment, Vomiting, Female, medicine.symptom, business, Tomography, Optical Coherence, medicine.drug
Abstract

Fluconazole is an antifungal commonly used to treat Coccidioides immitis, but this medication has a number of side effects including fatigue, rash, headache, dizziness, nausea, vomiting, diarrhea, and elevated liver enzymes. We are unaware of any cases of retinal toxicity related to fluconazole. In this case we present a 76 year old woman with longstanding Coccidioides treated with high dose fluconazole. She becomes symptomatic with fluconazole toxicity and subsequently develops bilateral cystoid macular edema. As her dose of fluconazole is decreased and she is transitioned to voriconazole the edema resolves and her visual acuity improves. This patient’s clinical course illustrates retinal toxicity may present with high and prolonged doses of fluconazole.

Published
2010

26. Morning Glory Optic Disc Anomaly

Author

George N. Magrath, Robert A. Sarrica, and Edward W. Cheeseman

Subjects
Male, Eye Diseases, business.industry, Optic Disk, Optic Nerve, Morning glory optic disc, Geodesy, Developmental Neuroscience, Neurology, Child, Preschool, Pediatrics, Perinatology and Child Health, Humans, Medicine, Neurology (clinical), Fluorescein Angiography, Anomaly (physics), business
Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results