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A biologic is a therapeutic agent with biological activity that is administered to achieve an enhanced regenerative or reparative effect. The use of biologics has progressively become a core component of contemporary periodontal practice. However, some questions remain about their safety, indications, and effectiveness in specific clinical scenarios. Given their availability for routine clinical use and the existing amount of related evidence, the goal of this American Academy of Periodontology (AAP) best evidence consensus (BEC) was to provide a state-of-the-art, evidence-based perspective on the therapeutic application of autologous blood-derived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet-derived growth factor BB (rhPDGF-BB), and recombinant human bone morphogenetic protein 2 (rhBMP-2). A panel of experts with extensive knowledge on the science and clinical application of biologics was convened. Three systematic reviews covering the areas of periodontal plastic surgery, treatment of infrabony defects, and alveolar ridge preservation/reconstruction and implant site development were conducted a priori and provided the foundation for the deliberations. The expert panel debated the merits of published data and exchanged experiential information to formulate evidence-based consensus statements and recommendations for clinical practice and future research. Based on an analysis of the current evidence and expert opinion, the panel concluded that the appropriate use of biologics in periodontal practice is generally safe and provides added benefits to conventional treatment approaches. However, therapeutic benefits and risks range based on the specific biologics used as well as patient-related local and systemic factors. Given the limited evidence available for some indications (e.g., gingival augmentation therapy, alveolar ridge preservation/reconstruction, and implant site development), future clinical studies that can expand the knowledge base on the clinical use of biologics in periodontal practice are warranted.

Focused clinical question What are the key considerations for the interdisciplinary dentofacial therapy (IDT) team in the diagnostic process to evaluate a patient for surgically facilitated orthodontic therapy (SFOT)? Summary SFOT creates a demineralized bone matrix and augments dentoalveolar deficiencies in the management of dentofacial disharmony malocclusion. Numerous indications and contraindications exist which are essential to the periodontal surgeon for proper case selection. A collaboratively focused workup by an IDT team is equally essential. Cone beam computed tomography (CBCT) and orthodontic simulation software which identifies changes in the dentoalveolar complex influenced by tooth movement are critical in providing transparency to the patient and IDT team during the treatment planning process. Such transparency can aid the team in assessing goals and outcomes that consider and respect foundational dentoalveolar parameters while contributing to sustainable outcomes. Conclusions The SFOT IDT decision making process is complex, yet full of opportunities. Embracing SFOT IDT with innovative and novel 3D technology can optimize conditions leading to long-term outcomes that align with periodontal stability as well as patient goals and preferences which permeate beyond the achievement of "straightening teeth". Transparency of complex IDT through 3D CBCT and orthodontic simulation software engenders "collaborative accountability" and can improve patient communication which is critical to developing meaningful and essential treatment plans.

Trace registration is a new, alternative registration method for dynamic navigation implant surgery that eliminates the need for an artificial fiducial marker and stent to be present in the CBCT scan, substituting it with other high-contrast landmarks such as teeth, implants, or abutments. Clinical advantages include a streamlined, simplified workflow with fewer opportunities for error; elimination of presurgical steps associated with stent fabrication and imaging; and reduction in radiation risk. Sufficient high-contrast intraoral structures are a prerequisite for using this technique. This case series presents the trace registration protocol and workflow and reports on cases that demonstrate the application of this technology, including postoperative placement accuracy evaluation.

Pterygoid implant placement has not been a common treatment modality to manage the atrophic posterior maxilla. This randomized, controlled clinical trial evaluated the accuracy of dynamic navigation using trace registration (TR) technology in pterygoid implant placement when compared to free-hand surgery. Partially edentulous patients requiring at least one pterygoid implant to rehabilitate the atrophic posterior maxilla were included. Implant accuracy (in a prosthetically directed context) and the relation of the placed implants to the greater palatine canal (GPC) were evaluated using EvaluNav to compare the preoperative CBCT plan with the postoperative CBCT implant location. Osseointegration success, mucosal thickness, implant length, time spent for surgical placement, and ease of prosthetic restorability via degree of multi-unit abutment angulation were assessed. A total of 63 pterygoid implants were placed (31 using TR, 32 using free-hand) in 39 partially edentulous patients. Mean deviations between the planned and actual position for TR-placed implants were 0.66 mm at the coronal level, 1.13 mm at the apical level, 0.67 mm in depth, and 2.64 degrees of angular deviation, compared to 1.54 mm, 2.73 mm, 1.17 mm, and 12.49 degrees, respectively, for free-hand implants. In relation to the GPC, TR implants were more accurate when compared to the presurgical plan and took less surgical time. The mean mucosal thickness measured for all implants was 5.41 mm. Most implants were 15 to 18 mm long, and most prostheses (92%) could be accommodated by a 17- or 30-degree multi-unit screw-retained abutment. TR implants had greater short-term osseointegration success rates than free-hand implants (100% vs 93.75%). Pterygoid implant surgery can be a predictable and successful modality for prosthetically directed implant rehabilitation in the atrophic posterior maxilla, is more accurate than free-hand surgery, and takes less time when using dynamic navigation via TR.

Background: The aim of this systematic review is to evaluate whether cone‐beam computed tomography (CBCT) imaging can be used to assess dentoalveolar anatomy critical to the periodontist when determining risk assessment for patients undergoing orthodontic therapy using fixed or removable appliances. Methods: Both observational and interventional trials reporting on the use of CBCT imaging assessing the impact of orthodontic/dentofacial orthopedic treatment on periodontal tissues (i.e., alveolar bone) were included. Changes in the alveolar bone thickness and height around natural teeth as well as treatment costs were evaluated. MEDLINE (via PubMed) and EMBASE databases were searched for articles published in the English language, up to and including July 2016, and extracted data were organized into evidence tables. Results: Thirteen studies were included in this systematic review describing the positive or deleterious changes on the alveolar bone surrounding natural teeth undergoing orthodontic tooth movement or influenced by orthopedic forces through fixed appliances. Clinical recommendation summaries presenting the strengths and weaknesses of the evidence in terms of benefits and harms were generated. Conclusions: CBCT imaging can improve the periodontal diagnostic acumen regarding alveolar bone alterations influenced by orthodontic tooth movement and can help determine risk assessment prior to such intervention. Clinicians are also better informed to determine risk assessment and develop preventative or plan interceptive periodontal augmentation (soft tissue and/or bone augmentation) therapies for patients undergoing orthodontic tooth movement. These considerations are recognized as being especially critical for treatment approaches in patients where buccal tooth movement (expansion) is planned in the anterior mandible or involving the maxillary premolars.

A minimally invasive implant treatment approach for future full arch implant prosthetic rehabilitations of trophic jaws represents a challenge. An optimal implant planning is strongly related with an accurate merge of the prosthetic information and the radiographic data. To comply with that, most computer aided implantology (CAI) systems require additional steps, as radiographic stents or fiducial markers to overlap digital jaw scans to cone beam computed tomography (CBCT) data. Using dynamic CAI, residual teeth (up to three) make it possible for the merge to avoid new radiographic scans. An additional challenge is the treatment involving immediate implants compared with delayed implants placed into healed bone. As for other static CAI systems, the operator&rsquo, s experience and the quality of the CBCT data make the planning affordable and secure the entire implants placement procedure. The literature reports accuracies in terms of comparison between placed implants and planned implants, following a double CBCT approach, based on radiographic volume overlapping. Thirteen consecutive future totally edentulous patients (77 implants), divided into two groups (group A: 3&ndash, 4 teeth traced, group B: 5&ndash, 6 teeth traced) requiring a full arch implant prosthetic rehabilitation were included in the reported case series. A dynamic CAI was used to plan and to place all implants following all the recommended digital steps. The software used provided a tool (Trace and Place) that made the merge between X-ray views of the residual teeth and their own positions possible. This method definitely registered that teeth positions comply with the required accuracy live check. After implants placement, a post-operative CBCT was taken in order to evaluate the deviations of the achieved implants at coronal, apical, and depth level as well as angular deviations. Statistically significant radiological mean difference between the two groups was found in the coronal position of implants (0.26 mm, p &lt, 0.001), in the apical position of implants (0.29 mm, p &lt, 0.001), in the depth of implants (0.16 mm, p = 0.022), and in the angular deviation (0.7, p = 0.004). The use of the TaP technology for the treatment of the patients with at least three stable teeth that need to be removed for a totally implant prosthetic treatment is a promising technique. The performed accuracy analysis demonstrated that this digital protocol can be used without a loss of accuracy of the achieved implants compared to planned ones.

The use of pterygoid implants can be an attractive alternative to sinus bone grafting in the treatment of posterior atrophic maxilla. This technique has not been widely used because of the difficulty of the surgical access, the presence of vital structures, and the prosthetic challenges. The use of dynamic computer aided implantology (DCAI) allows the clinician to utilize navigation dental implant surgery, which allows the surgeon to follow the osteotomy site and implant positioning in real time. A total of 14 patients (28 pterygoid implants and 56 intersinusal implants) were enrolled in the study for a full arch implant prosthetic rehabilitation (4 frontal implants and 2 pterygoids implants), using a dynamic navigation system. The reported accuracy of pterygoid implants inserted using DCAI was 0.72 mm at coronal point, 1.25 mm at apical 3D, 0.66 mm at apical depth, and 2.86&deg, as angular deviation. The use of pterygoid implants in lieu of bone grafting represents a valid treatment opportunity to carry out a safe, accurate, and minimally invasive surgery, while reducing treatment time and avoiding cantilevers for a full implant prosthetic rehabilitation of the upper arch.

Purpose To evaluate the in vivo accuracy of dental implants placed using a dynamic computer-aided dental implant (CAI) navigation system. The impact of various factors on accuracy was also analyzed. Materials and methods A retrospective, in vivo study was performed during the period of October 2015 to December 2017. Data were obtained on all implants placed during this time frame. A chart review was conducted to identify the type of flap, number of implants placed, number of patients treated, and factors related to the description of edentulism (partial or complete). To evaluate accuracy outcomes, the preoperative cone beam computed tomography (CBCT) plan was volumetrically registered to a postimplant placement CBCT scan. Deviations between the planned and placed implant positions were analyzed. Data were statistically analyzed to factors that may affect the accuracy during usage. Results Data were obtained on 231 implants placed in healed ridges using a flapless or minimal flap approach under dynamic guidance by a single surgeon. In the 89 arches operated on, 28 (125 implants) were fully edentulous. For all implants, the mean (SD) discrepancies were: 0.71 (0.40) mm for entry point (lateral) and 1.00 (0.49) mm at the apex (3D). The mean angle discrepancy was 2.26 degrees (1.62 degrees) from actual vs planned implant positions. The accuracy measurements for partially edentulous patients using a thermoplastic stent attachment and for fully edentulous patients using a mini-implant-based attachment were nearly identical. No significant accuracy differences were found between implant position within the different sextants. Guided insertion of the implant itself reduced angular and apex location deviations. The accuracy of implant placement improved during the study period, with the mean entry point and apex deviation as well as overall angle discrepancy measured for the last 50 implants being better (0.59 mm, 0.85 mm, and 1.98 degrees, respectively) when compared with the first 50 implants (0.94 mm, 1.19 mm, and 3.48 degrees, respectively). Conclusion Dynamic surgical navigation is an accurate method for executing CBCT-based computer-aided implant surgery. In addition, an increased experience level of the surgeon with dynamic navigation appears to improve accuracy outcomes.

A technology called Trace Registration (TR) has been introduced to allow dynamic navigation of implant placement without the need for a thermoplastic stent. This study was undertaken in order to validate the accuracy of the TR protocol for dynamically guided implant surgery. A retrospective, observational, in vivo study was performed using dynamic navigation via the TR protocol. The preoperative cone beam computed tomography (CBCT) plan was superimposed and registered (aligned) with the postoperative CBCT scan to assess accuracy parameters. A total of 136 implants were placed in 59 partially edentulous arches. Mean deviation between the planned and actual position for all implants was 0.67 mm at the coronal level (entry point), 0.9 mm at the apical level, and 0.55 mm in depth, with an angle discrepancy of 2.50 degrees. Tracing 5 to 6 teeth tended to improve accuracy results compared to tracing 3 to 4 teeth. TR is as accurate as traditional registration and statically guided methods for implant surgery.

The American Academy of Periodontology (AAP) recently embarked on a Best Evidence Consensus (BEC) model of scientific inquiry to address questions of clinical importance in periodontology for which there is insufficient evidence to arrive at a definitive conclusion. This review addresses oral indications for use of cone-beam computed tomography (CBCT).To develop the BEC, the AAP convened a panel of experts with knowledge of CBCT and substantial experience in applying CBCT to a broad range of clinical scenarios that involve critical structures in the oral cavity. The panel examined a clinical scenario or treatment decision that would likely benefit from additional evidence and interpretation of evidence, performed a systematic review on the individual, debated the merits of published data and experiential information, developed a consensus report, and provided a clinical bottom line based on the best evidence available.This BEC addressed the potential value and limitations of CBCT relative to specific applications in the management of patients requiring or being considered for the following clinical therapies: 1) placement of dental implants; 2) interdisciplinary dentofacial therapy involving orthodontic tooth movement in the management of malocclusion with associated risk on the supporting periodontal tissues (namely, dentoalveolar bone); and 3) management of periodontitis.For each specific question addressed, there is a critical mass of evidence, but insufficient evidence to support broad conclusions or definitive clinical practice guidelines.

Comorbidities that negatively impact orthodontic (malocclusion), periodontal (periodontitis, deficient dentoalveolar bone volume, mucogingival), and prosthetic (structural integrity compromise from caries, attrition, and erosion) conditions can affect the general health of the patient. In addition, emerging data highlights the importance of undiagnosed airway volume deficiencies and sleep-disordered breathing conditions in the adult and pediatric population. Deficiencies in dentoalveolar bone and discrepancies in alveoloskeletal relationships can impact the volume of hard and soft tissue structures of the periodontium and decrease oral cavity volume. Contemporary interdisciplinary dentofacial therapy (IDT) is a key process for addressing the comprehensive problems of patients based on etiology, homeostasis, and sustainability of physiologically sound outcomes. These provide the patient with sustainable esthetics and function. Surgically facilitated orthodontic therapy (SFOT) uses corticotomies and dentoalveolar bone decortication to stimulate the regional acceleratory phenomenon and upregulate bone remodeling and tooth movement as a part of orthodontic decompensation. It also generally includes guided periodontal tissue regeneration and/or dentoalveolar bone augmentation via particulate bone grafting. SFOT enhances the dentoalveolar bone phenotype and augments the orthodontic boundary conditions as well as expanding orthodontic treatment opportunities for challenging malocclusion cases. SFOT as a part of IDT is demanding and requires extensive attention and communication among all team members. This chapter focuses on the role of SFOT as an integral component of contemporary IDT to enhance and facilitate highly predictable and sustainable outcomes.

FOCUSED CLINICAL QUESTION Surgically facilitated orthodontic treatment (SFOT)/periodontally accelerated osteogenic orthodontics (PAOO) has the potential of allowing safer orthodontic treatment in vulnerable periodontium with thin phenotypes. SFOT/PAOO is a phenotype modification therapy (PhMT) approach where thin bone morphotype and/or gingiva are surgically augmented to convert a fragile-thin to a robust-thick periodontal environment. This permits orthodontic treatment in these previously thin phenotype cases to proceed without iatrogenically-induced adverse effects. This is an infrequently performed procedure with few available clinical recommendations. SUMMARY In this practical application paper, three clinicians with the collective clinical experience of over 1500 SFOT cases developed a clinical decision-making algorithm outlining the key steps for SFOT. A sample case is provided for clinical appreciation of the procedure. Lastly, this panel reviewed and detailed the critical decision making and surgical approaches associated with the use of SFOT. Though the basic decision making is consistent, individual variations on surgical management are compared. This is summarized in a clinical decision tree along with a sample clinical case. Additionally, the cumulative experience has been organized into tables that provide comparative decision and surgical approaches. There are similarities and differences. Lastly, strategies that have not been individually effective are also noted. CONCLUSION SFOT/PAOO is an effective PhMT approach whereby the bone and/or soft tissue phenotype can be surgically modified to permit orthodontic treatment in patients with thin phenotypes. The cumulative experience of three experienced clinicians provides clinical recommendations for SFOT management of PhMT for pre-orthodontic treatment.

Background Orthodontic treatment can greatly impact the periodontium, especially in dentitions with a thin periodontal phenotype. Orthodontic tooth movement can result into iatrogenic sequelae to these vulnerable anatomic conditions, such as development and exacerbation of bony dehiscence or fenestration defects, which can manifest loss of periodontal support and gingival recession (GR). This systematic review aimed to investigate whether periodontal phenotype modification therapy (PhMT) involving hard tissue augmentation (PhMT-b) or soft tissue augmentation (PhMT-s) has clinical benefits for patients undergoing orthodontic treatment. Methods An electronic search was performed in two major databases for journals published in English language from January 1975 to January 2019 and a hand search of printed journals was also performed to identify human clinical trials reporting clinical and radiographic outcomes of patients receiving orthodontic treatment with or without hard and soft tissue augmentation procedures. Data were extracted and organized into tables for qualitative assessment. Results Eight studies were identified evaluating the outcomes of PhMT in patients undergoing orthodontic therapy. Six studies evaluated patients receiving PhMT-b via corticotomy-assisted orthodontic therapy (CAOT) and simultaneous bone augmentation while the other two received PhMT-s before tooth movement. No studies investigated PhMT-b alone without CAOT and most studies focused on the mandibular anterior decompensation movements. There was high heterogeneity in the study design and inconsistency of the reported outcomes; therefore, a meta-analysis was not performed. Evidence at this moment supports CAOT with hard tissue augmentation accelerated tooth movement. However, only two studies provided direct comparison to support that CAOT with PhMT-b reduced the overall treatment time compared with conventional orthodontic treatment. No periodontal complications or evidence of severe root resorption were reported for both groups. Four studies provided radiographic assessment of the PhMT-b and demonstrated increased radiographic density or thicker facial bone after the treatment. Two studies reported an expanded tooth movement. One study reported an increase in keratinized tissue width post-CAOT plus PhMT-b, while another study with a 10-year follow-up showed a lower degree of relapse using the mandibular irregularity index when compared with conventional tooth movement alone. Two studies examined the effect of PhMT-s before orthodontic treatment. Unfortunately, no conclusions can be drawn because of the limited number of studies with contradicting outcomes. Conclusions Within the limited studies included in this systematic review, PhMT-b via particulate bone grafting together with CAOT may provide clinical benefits such as modifying periodontal phenotype, maintaining or enhancing facial bone thickness, accelerating tooth movement, expanding the scope of safe tooth movement for patients undergoing orthodontic tooth movement. The benefits of PhMT-s alone for orthodontic treatment remain undetermined due to limited studies available. However, PhMT-b appears promising and with many potential benefits for patients undergoing orthodontic tooth movement. There is a need for a higher quality of randomized controlled trials or case control studies with longer follow-up to investigate the effects of different grafting materials and surgical sites other than mandibular anterior region.

Over the course of several decades implant dentistry has evolved to include 3-dimensionally (3D) planned and guided surgery. One of the latest innovations is dynamic navigation, which may allow surgeons to place implants with accuracy similar to stereolithographic guides based on 3D, prosthetically directed plans. Benefits of dynamically guided surgery include real-time feedback, a streamlined digital workflow, improved surgical visualization, and adaptability to intraoperative findings. This article discusses the technology and workflow of dynamic navigation and its application for guided implant placement. Additionally, a case completed using this technology is presented.

Comorbidities that negatively impact orthodontic (malocclusion), periodontal (periodontitis, deficient dentoalveolar bone volume, mucogingival), and prosthetic (structural integrity compromise from caries, attrition, and erosion) conditions can affect the general health of the patient. In addition, emerging data highlights the importance of undiagnosed airway volume deficiencies and sleep-disordered breathing conditions in the adult and pediatric population. Deficiencies in dentoalveolar bone and discrepancies in skeletal relationships can impact the volume of hard- and soft-tissue structures of the periodontium and decrease oral cavity volume. Contemporary interdisciplinary dentofacial therapy (IDT) is a key process for addressing the comprehensive problems of patients based on etiology, homeostasis, and sustainability of physiologically sound outcomes. These provide the patient with sustainable esthetics and function. Surgically facilitated orthodontic therapy (SFOT) uses corticotomies and dentoalveolar bone decortication to stimulate the regional acceleratory phenomenon and upregulate bone remodeling and tooth movement as a part of orthodontic decompensation. It also generally includes guided periodontal tissue regeneration and/or dentoalveolar bone augmentation. SFOT as a part of IDT is demanding and requires extensive attentiveness and communication among all team members. This article focuses on the role of SFOT as an integral component of contemporary IDT to facilitate highly predictable and sustainable outcomes.

A 26-year-old woman was referred to a periodontal surgical practice for concerns related to gingival recession. After several consultations among the orthodontist, periodontist, and cosmetic/restorative dentist, she decided to have surgically facilitated orthodontic therapy as part of a collaborative, interdisciplinary treatment planning process to correct her constricted maxillary arch form, augment thin dentoalveolar facial bone, simultaneously with gaining root coverage as well as improving attached gingiva width and mucogingival thickness. As a consequence of changing the arch form, an improvement in the buccal corridor space was gained which optimized her smile display.

Focused Clinical Question: Can emerging technologies for periodontal regeneration become clinical reality? Summary: Emerging technologies are presenting options to hopefully improve the outcomes of regeneration in challenging clinical scenarios. Cellular allografts represent a current technology in which cells and scaffolds are being delivered directly to the periodontal lesion. Recombinant human fibroblast growth factor 2 and teriparatide (parathyroid 1-34) have each been tested in controlled prospective human randomized clinical trials, and both have been shown to have potential for periodontal regeneration. These examples, as well as other emerging technologies, show promise for continued advancement in the field of periodontal regenerative therapy. Conclusions: At present, there are indications that emerging technologies can be used successfully for periodontal regeneration. Case reports and clinical trials are being conducted with a variety of emerging technologies. However, many are yet to be approved by a regulatory agency, or there is a lack of evidence-based literature to validate their expanded use.

Background: Historically, periodontal regeneration has focused predominantly on bone substitutes and/or barrier membrane application to provide for defect fill and/or selected cell repopulation of the lesion. More recently, a number of technologies have evolved that can be viewed as emerging therapeutic approaches for periodontal regeneration, and these technologies were considered in the review paper and by the consensus group. The goal of this consensus report on emerging regenerative approaches for periodontal hard and soft tissue reconstruction was to develop a consensus document based on the accompanying review paper and on additional materials submitted before and at the consensus group session. Methods: The review paper was sent to all the consensus group participants in advance of the consensus conference. In addition and also before the conference, individual consensus group members submitted additional material for consideration by the group. At the conference, each consensus group participant introduced themselves and provided disclosure of any potential conflicts of interest. The review paper was briefly presented by two of the authors and discussed by the consensus group. A discussion of each of the following topics then occurred based on the content of the review: a general summary of the topic, implications for patient-reported outcomes, and suggested research priorities for the future. As each topic was discussed based on the review article, supplemental information was then added that the consensus group agreed on. Last, an updated reference list was created. Results: The application of protein and peptide therapy, cell-based therapy, genetic therapy, application of scaffolds, bone anabolics, and lasers were found to be emerging technologies for periodontal regeneration. Other approaches included the following: 1) therapies directed at the resolution of inflammation; 2) therapies that took into account the influence of the microbiome; 3) therapies involving the local regulation of phosphate and pyrophosphate metabolism; and 4) approaches directed at harnessing current therapies used for other purposes. The results indicate that, with most emerging technologies, the specific mechanisms of action are not well understood nor are the specific target cells identified. Patient-related outcomes were typically not addressed in the literature. Numerous recommendations can be made for future research priorities for both basic science and clinical application of emerging therapies. The need to emphasize the importance of regeneration of a functional periodontal organ system was noted. The predictability and efficacy of outcomes, as well as safety concerns and the cost-to-benefit ratio were also identified as key factors for emerging technologies. Conclusions: A number of technologies appear viable as emerging regenerative approaches for periodontal hard and soft tissue regeneration and are expanding the potential of reconstructing the entire periodontal organ system. The cost-to-benefit ratio and safety issues are important considerations for any new emerging therapies. Clinical Recommendation: At this time, there is insufficient evidence on emerging periodontal regenerative technologies to warrant definitive clinical recommendations. J Periodontol 2015;86(Suppl.):S153-S156.

Tooth loss leads to many challenges in order to restore the dentition for esthetics and function. These challenges range in complexity from engineering the appropriate type of prosthesis and supporting teeth (as with traditional prosthodontics) to advanced surgical planning and therapies to maintain or reconstruct the alveolar ridge. The ultimate goal is directed towards compensating for tooth loss with dental implants, when appropriate. While shape and size of the residual alveolar ridge are important for function and esthetics in fixed and removable prosthetics, these become critical when dental implants are used to restore an edentulous space. In these circumstances, maintenance of the native bone or reconstruction of the atrophic jaw is mandatory.

Pretreatment knowledge of crestal and radicular dentoalveolar zones and their associated thicknesses can improve risk assessment to meet esthetic and functional goals, particularly when discrepancies in anterior maxillary and mandibular arches exist and when an anterior protected articulation is to be achieved. This paper discusses a new classification of dentoalveolar bone phenotypes that differentiates the alveolar crestal zone from that of the radicular zone and classifies the thickness of facial bone at each compartment to aid in interdisciplinary dentofacial therapy risk assessment. The zone of crestal bone is defined as the region of the tooth alveolus measured from the cementoenamel junction (CEJ) to a point 4 mm apical. The dentoalveolar radicular zone is dependent upon the individual root length. It begins at a point 4 mm apical to the CEJ (base of the crestal zone) and extends the length of the tooth root. Dentoalveolar bone phenotype at both zones (crestal and remaining radicular alveolar aspect) can be categorized as either thick or thin. Thick is defined as ≥ 1 mm of facial bone width while thin is < 1 mm.

Of all the modalities reported to decrease orthodontic treatment time, corticotomy-accelerated orthodontics (CAO) is the only evidence-based approach. The aim of this article is to critically review the available evidence and to summarize the pros and cons of CAO. Articles published in the last 15 years related to CAO were screened and critically assessed. Based on the literature, CAO results in acceleration of the orthodontic treatment rate as much as three times on average, in addition to many benefits not commonly recognized by the profession or reported in the literature. CAO is effective and safe for shortening the orthodontic treatment time, as well as for enhancing interdisciplinary outcomes beyond what conventional treatment alone is able to yield. More investigations are needed to validate and verify, as well as understand, the long-term implications to treatment from both a periodontal and orthodontic outcome standpoint.

Aim To compare the effectiveness of two-ridge preservation treatments. Materials and Methods 40 subjects with extraction sockets exhibiting substantial buccal dehiscences were enrolled and randomized across 10 standardized centers. Treatments were demineralized allograft plus reconstituted and cross-linked collagen membrane (DFDBA+RECXC) or deproteinized bovine bone mineral with collagen plus native, bilayer collagen membrane (DBBMC+NBCM). Socket dimensions were recorded at baseline and 6-months. Wound closure and soft tissue inflammation were followed post-operatively, and biopsies were retrieved for histomorphometric analysis at 6-months. Results Primary endpoint: at 6-months extraction socket horizontal measures were significantly greater for DBBMC+NBCM (average 1.76 mm greater, p= 0.0256). Secondary and Exploratory endpoints: (1) lingual and buccal vertical bone changes were not significantly different between the two treatment modalities, (2) histomorphometric % new bone and % new bone+graft were not significantly different, but significantly more graft remnants remained for DBBMC; (3) at 1-month incision line gaps were significantly greater and more incision lines remained open for DFDBA+RECXC; (4) higher inflammation at 1-week tended to correlate with lower ridge preservation results; and (5) deeper socket morphologies with thinner bony walls correlated with better ridge preservation. 37 of 40 sites had sufficient ridge dimension for implant placement at 6-months; the remainder were DFDBA+RECXC sites. Conclusion DBBMC+NBCM provided better soft tissue healing and ridge preservation for implant placement. Deeper extraction sockets with higher and more intact bony walls responded more favorably to ridge preservation therapy. Further investigation of implant integration and long-term survival is warranted. clinicaltrials. gov identifier NCT02330523. This article is protected by copyright. All rights reserved.

Background Historically, implants were placed in the available bone with little consideration of the prosthetic rehabilitation. More recently, a ‘‘top-down, prosthetically driven’’ approach using conventional surgical templates has been used to ensure optimal final tooth position. Understanding the planned prosthetic outcome during surgical placement improves the predictability of implant restorations based on providing a visual positioning reference. Interactive computed tomography (CT) technology has allowed for greater preoperative knowledge of a patient’s anatomy, aiding in diagnosis and strategic execution of therapy. In addition, CT-based analysis provides for prosthetic and surgical performance objectives to be established before the rendering of irreversible treatment. Furthermore, this process allows for preoperative collaboration among the restoring dentist, laboratory technologist, surgeon, and patient. This multistep process has been called ‘‘collaborative accountability.’’1

Introduction: Keratinized and dense peri-implant soft tissue around implants has been associated with better tissue health, less bone loss, and improved esthetics. The purpose of this case report is to evaluate a new, xenogeneic collagen matrix (CM) as an interpositional soft-tissue graft to enhance peri-implant soft-tissue thickness. To our knowledge, this is the first such case report to include soft-tissue biopsies and histologic analysis.Case Presentation: After extraction and bone grafting of a mandibular left first molar, the patient received a dental implant, and CM was used as an interpositional soft-tissue graft. Clinical healing was uneventful, and the impression of enhanced soft-tissue volume/thickness was observed. At 10 weeks, biopsies were taken from the operative site and from a contralateral, non-operated site. Histologic assessment of the operative site demonstrated normal squamous epithelium and lamina propria. Tissue growing into the residual CM also appeared normal, with no inflammator...

Computed tomography (CT) and the application of CT-based guided implant surgery allow clinicians to provide enhanced precision and accuracy in implant surgery. Because of the difficulty in transferring a patient's often complex anatomic sinus configurations, as viewed on a preoperative CT scan, into precise osteotomy cuts at antral bone graft surgery, a prototype cutting guide was developed. The surgical guide was developed through the use of CT imaging, SimPlant module Oral and Maxillofacial Surgery computer software (Materialise Dental, Glen Burnie, MD), and the stereolithographic process to precisely position the lateral window, facilitating Schneiderian membrane elevation. This report demonstrates the step-by-step method to perform precise guided sinus window preparation using computer software and a stereolithographically generated surgical guide.

A 26-year-old woman was referred to a periodontal surgical practice for concerns related to gingival recession. After several consultations among the orthodontist, periodontist, and cosmetic/restorative dentist, she decided to have surgically facilitated orthodontic therapy as part of a collaborative, interdisciplinary treatment planning process to correct her constricted maxillary arch form, augment thin dentoalveolar facial bone, simultaneously with gaining root coverage as well as improving attached gingiva width and mucogingival thickness. As a consequence of changing the arch form, an improvement in the buccal corridor space was gained which optimized her smile display.

This case report describes a tissue-engineered reconstruction with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ ACS) + cancellous allograft and space maintenance via Medpor Contain mesh in the treatment of a patient requiring maxillary and mandibular horizontal ridge augmentation to enable implant placement. The patient underwent a previously unsuccessful corticocancellous bone graft at these sites. Multiple and contiguous sites in the maxilla and in the mandibular anterior, demonstrating advanced lateral ridge deficiencies, were managed using a tissue engineering approach as an alternative to autogenous bone harvesting. Four maxillary and three mandibular implants were placed 9 and 10 months, respectively, after tissue engineering reconstruction, and all were functioning successfully after 24 months of follow-up. Histomorphometric analysis of a bone core obtained at the time of the maxillary implant placement demonstrated a mean of 76.1% new vital bone formation, 22.2% marrow/cells, and 1.7% residual graft tissue. Tissue engineering for lateral ridge augmentation with combination therapy requires further research to determine predictability and limitations.

Parallel use of implant treatment planning software and cone-beam computed tomography (CBCT) can, using certain criteria, consolidate steps and streamline tooth replacement strategies. The authors describe such a case in the esthetic zone whereby flapless extraction and immediate implant placement using CT-guided surgery were performed simultaneously, with placement of a computer-aided design/computer-aided manufactured (CAD/CAM) patient-specific abutment and non-occlusal function provisional in a single visit (supporting the "one-abutment, one-time" concept). An over-retained primary cuspid in a periodontally healthy woman with well-controlled type-2 diabetes was replaced with an implant and CAD/CAM patient-specific abutment in the No. 11 position. A necessary implant-axis angle correction was customized using digital information from a CBCT scan and implant treatment planning software, without the need for site development or a conventional impression. This data integration and streamlined workflow enabled fabrication of a CAD/CAM patient-specific abutment before surgical treatment. The abutment remained in place from implant surgery to the prosthetic phase, with minimal soft-tissue changes, enabling preservation of pink esthetics and expediting treatment. The result was a preserved emergence profile in the presence of high esthetic demands. However, due to slight post-extraction soft-tissue changes, digital reformatting of the abutment was required when the final crown was fabricated, thus limiting the disruption of the biologic width to a one-time occurrence. The importance of case selection for this treatment protocol in the esthetic zone cannot be overemphasized. A thick crestal dentoalveolar bone phenotype (1 mm, approaching 2 mm in this case), broad zone of attached and keratinized gingiva (3 mm to 4 mm in this case), adequate peri-implant soft-tissue thickness (1 mm in this case), and high primary implant stability (ISQ = 80 in this case) were all critical factors influencing outcome.

Focused Clinical Question: Can emerging technologies for periodontal regeneration become clinical reality? Summary: Emerging technologies are presenting options to hopefully improve the outcomes of regeneration in challenging clinical scenarios. Cellular allografts represent a current technology in which cells and scaffolds are being delivered directly to the periodontal lesion. Recombinant human fibroblast growth factor 2 and teriparatide (parathyroid 1-34) have each been tested in controlled prospective human randomized clinical trials, and both have been shown to have potential for periodontal regeneration. These examples, as well as other emerging technologies, show promise for continued advancement in the field of periodontal regenerative therapy. Conclusions: At present, there are indications that emerging technologies can be used successfully for periodontal regeneration. Case reports and clinical trials are being conducted with a variety of emerging technologies. However, many are yet to be approved by a regulatory agency, or there is a lack of evidence-based literature to validate their expanded use.

Computer-aided design/computer-assisted manufacture (CAD/CAM) guides for surgery are becoming a widespread tool in implant dentistry. This study sought to evaluate the accuracy and precision of a new guided surgery system. Twenty-five patients were treated in eight centers, and a total of 117 implants were placed using CAD/CAM surgical guides supported by bone, mucosa, and/or teeth. A postoperative computed tomographic (CT) scan of each patient was taken and superimposed on a preoperative CT scan to evaluate any discrepancies between the planned and actual implant positions (apex and platform positions), as well as the implant tilt. Implant placement using bone- and mucosa-supported guides was found to be more precise compared to using guides supported by teeth or a combination of teeth and mucosa. However, the differences were not statistically significant. The accuracy of the guided surgery system is in line with the data found in the literature. Considering the mean positioning discrepancies between the planned and actual implant outcomes, clinicians are advised to maintain a safe distance between implants and anatomical structures of at least 2 mm. In immediate loading cases, relining a provisional prosthesis to compensate for any discrepancies between the virtual and clinical implant positions is recommended.

Computer-aided design/computer-assisted manufacture (CAD/CAM) guides for surgery are becoming a widespread tool in implant dentistry. This study sought to evaluate the accuracy and precision of a new guided surgery system. Twenty-five patients were treated in eight centers, and a total of 117 implants were placed using CAD/CAM surgical guides supported by bone, mucosa, and/or teeth. A postoperative computed tomographic (CT) scan of each patient was taken and superimposed on a preoperative CT scan to evaluate any discrepancies between the planned and actual implant positions (apex and platform positions), as well as the implant tilt. Implant placement using bone- and mucosa-supported guides was found to be more precise compared to using guides supported by teeth or a combination of teeth and mucosa. However, the differences were not statistically significant. The accuracy of the guided surgery system is in line with the data found in the literature. Considering the mean positioning discrepancies between the planned and actual implant outcomes, clinicians are advised to maintain a safe distance between implants and anatomical structures of at least 2 mm. In immediate loading cases, relining a provisional prosthesis to compensate for any discrepancies between the virtual and clinical implant positions is recommended.

The application of computed tomography (CT) and the use of computer software for dental implant therapy have significantly increased during the last several years. Dental implant positioning can be either "partially guided," where only osteotomy sites are prepared using sequential, removable surgical drilling guides (generated using computer software and through the process of stereolithography), or "totally guided," whereby one guide is used for osteotomy site preparation as well as implant delivery. Recently, the guided delivery of manufacturer-specific internal-connection implants has become available. Individualized protocols and specific instrumentation are employed under this approach to CT-based implant surgery. The purpose of this article is to expand on previous publications related to the use of prosthetically directed implant placement using computer software to ensure precise placement and predictable prosthetic outcomes. Three case reports are presented where precision-guided CT-based surgery was employed and the immediate delivery of a dental prosthesis was facilitated.

This article presents the interdisciplinary management of a severe alveolar ridge defect to enable optimal implant placement and minimally invasive dentistry for an optimal functional and esthetic outcome. To attain the best esthetic and biologic results for implant placement, an interdisciplinary approach was used to synergistically combine orthodontics, periodontics, and restorative dentistry to simplify a complex periodontal restorative problem and minimize the procedures required for restoration of maximal esthetics and function.

The antral sinus bone graft has become one of the most predictable and commonly used surgical procedures to augment bone in the posterior maxilla and thereby accommodate implant placement. Positioning the lateral wall during this technique has traditionally been an intuitive process, whereby the surgeon relies on mental navigation to achieve proper identification. The purpose of this article is to introduce a prototype cutting guide that is developed through the use of computerized tomographic imaging, computer software, and the stereolithographic process to precisely position the lateral wall and facilitate Schneiderian membrane elevation. This prototype cutting guide marks the beginning of applications for "guided bone grafting" and associated techniques that focus on enhanced precision and accuracy in bone regeneration surgery.

Implant dentistry is changing. There are currently two types of computed tomogrophy (CT) scanners--multi-slice and cone beam--available to the dental professional. Computed tomography allows for proactive planning among the entire implant team and with the patient, a concept referred to as "collaborative accountability" In addition, CT surgical guidance that enhances accuracy and precision is available to ensure prosthetic outcomes. A logical and progressive approach is outlined that allows each clinician to assess how to embrace this paradigm shift in his or her clinical practice, and provide better and safer patient care.

Previous publications have reviewed the concepts of implant diagnostics and computerized tomographic imaging used together to create an atmosphere of collaborative accountability. The use of SimPlant software in combination with stereolithographic medical modeling facilitates the fabrication of surgical drilling guides, which assist in precise placement of dental implants. In this article, the use of gradient density scanning appliances will be discussed. This type of scanning appliance allows tooth- or mucosa-supported surgical drilling guides to be fabricated and used for implant placement without bone exposure. The use of the SAFE System will be introduced, along with its application in simplifying the immediate-loading prosthesis concept, which can often bypass the need for traditional dental impressions.

The purpose of this paper is to expand on part 1 of this series (published in the previous issue) regarding the emerging future of computer-guided implant dentistry. This article will introduce the concept of rapid-prototype medical modeling as well as describe the utilization and fabrication of computer-generated surgical drilling guides used during implant surgery. The placement of dental implants has traditionally been an intuitive process, whereby the surgeon relies on mental navigation to achieve optimal implant positioning. Through rapid-prototype medical modeling and the ste-reolithographic process, surgical drilling guides (eg, SurgiGuide) can be created. These guides are generated from a surgical implant plan created with a computer software system that incorporates all relevant prosthetic information from which the surgical plan is developed. The utilization of computer-generated planning and stereolithographically generated surgical drilling guides embraces the concept of collaborative accountability and supersedes traditional mental navigation on all levels of implant therapy.