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253 results on '"Garcia-Rodriguez J"'

1. Mathematical models and numerical methods for a capital valuation adjustment (KVA) problem

Author

Trevisani, D., López-Salas, J. G., Vázquez, C., and García-Rodríguez, J. A.

Subjects
Mathematics - Analysis of PDEs
Abstract

In this work we rigorously establish mathematical models to obtain the capital valuation adjustment (KVA) as part of the total valuation adjustments (XVAs). For this purpose, we use a semi-replication strategy based on market theory. We formulate single-factor models in terms of expectations and PDEs. For PDEs formulation, we rigorously obtain the existence and uniqueness of the solution, as well as some regularity and qualitative properties of the solution. Moreover, appropriate numerical methods are proposed for solving the corresponding PDEs. Finally, some examples show the numerical results for call and put European options and the corresponding XVA that includes the KVA.

Published
2024
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2. Boundary treatment for high-order IMEX Runge-Kutta local discontinuous Galerkin schemes for multidimensional nonlinear parabolic PDEs

Author

González-Tabernero, V., López-Salas, J. G., Castro-Díaz, M. J., and García-Rodríguez, J. A.

Subjects
Mathematics - Numerical Analysis, Quantitative Finance - Computational Finance, Quantitative Finance - Mathematical Finance
Abstract

In this article, we propose novel boundary treatment algorithms to avoid order reduction when implicit-explicit Runge-Kutta time discretization is used for solving convection-diffusion-reaction problems with time-dependent Di\-richlet boundary conditions. We consider Cartesian meshes and PDEs with stiff terms coming from the diffusive parts of the PDE. The algorithms treat boundary values at the implicit-explicit internal stages in the same way as the interior points. The boundary treatment strategy is designed to work with multidimensional problems with possible nonlinear advection and source terms. The proposed methods recover the designed order of convergence by numerical verification. For the spatial discretization, in this work, we consider Local Discontinuous Galerkin methods, although the developed boundary treatment algorithms can operate with other discretization schemes in space, such as Finite Differences, Finite Elements or Finite Volumes.

Published
2024

3. A second order finite volume IMEX Runge-Kutta scheme for two dimensional PDEs in finance

Author

López-Salas, J. G., Suárez-Taboada, M., Castro, M. J., Ferreiro-Ferreiro, A. M., and García-Rodríguez, J. A.

Subjects
Mathematics - Numerical Analysis, Quantitative Finance - Computational Finance, Quantitative Finance - Mathematical Finance
Abstract

In this article we present a novel and general methodology for building second order finite volume implicit-explicit (IMEX) numerical schemes for solving two dimensional financial parabolic PDEs with mixed derivatives. In particular, applications to basket and Heston models are presented. The obtained numerical schemes have excellent properties and are able to overcome the well-documented difficulties related with numerical approximations in the financial literature. The methods achieve true second order convergence with non-regular initial conditions. Besides, the IMEX time integrator allows to overcome the tiny time-step induced by the diffusive term in the explicit schemes, also providing very accurate and non-oscillatory approximations of the Greeks. Finally, in order to assess all the aforementioned good properties of the developed numerical schemes, we compute extremely accurate semi-analytic solutions using multi-dimensional Fourier cosine expansions. A novel technique to truncate the Fourier series for basket options is presented and it is efficiently implemented using multi-GPUs., Comment: arXiv admin note: substantial text overlap with arXiv:2409.01131

Published
2024

4. Second order finite volume IMEX Runge-Kutta schemes for two dimensional parabolic PDEs in finance

Author

López-Salas, J. G., Suárez-Taboada, M., Castro, M. J., Ferreiro-Ferreiro, A. M., and García-Rodríguez, J. A.

Subjects
Mathematics - Numerical Analysis
Abstract

We present a novel and general methodology for building second-order finite volume implicit-explicit Runge-Kutta numerical schemes for solving two-dimensional financial parabolic PDEs with mixed derivatives. The methods achieve second-order convergence even in the presence of non-regular initial conditions. The IMEX time integrator allows to overcome the tiny time-step induced by the diffusive term in the explicit schemes, also providing accurate and non-oscillatory approximations of the Greeks.

Published
2024
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5. IMEX-RK finite volume methods for nonlinear 1d parabolic PDEs. Application to option pricing

Author

López-Salas, J. G., Suárez-Taboada, M., Castro, M. J., Ferreiro-Ferreiro, A. M., and García-Rodríguez, J. A.

Subjects
Mathematics - Numerical Analysis, Mathematics - Analysis of PDEs
Abstract

The goal of this paper is to develop 2nd order Implicit-Explicit Runge-Kutta (IMEX-RK) finite volume (FV) schemes for solving 1d parabolic PDEs for option pricing, with possible nonlinearities in the source and advection terms. The spatial semi-discretization of the advection is carried out by combining finite volume methods with 2nd order state reconstructions; while the diffusive terms are discretized using second-order finite differences. The time integration is performed by means of IMEX-RK time integrators: the advection is treated explicitly, and the diffusion, implicitly. The obtained numerical schemes have several advantages: they are computationally very efficient, thanks to the implicit discretization of the diffusion in the IMEX-RK time integrators, which allows to overcome the strict time step restriction; they yield second-order accuracy for even nonlinear problems and with non-regular initial conditions; and they can be extended to higher order.

Published
2024
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6. Global optimization for data assimilation in landslide tsunamis models

Author

Ferreiro-Ferreiro, A. M., García-Rodríguez, J. A., López-Salas, J. G., Escalante, C., and Castro, M. J.

Subjects
Physics - Geophysics, Mathematics - Numerical Analysis
Abstract

The goal of this article is to make automatic data assimilation for a landslide tsunami model, given by the coupling between a non-hydrostatic multi-layer shallow-water and a Savage-Hutter granular landslide model for submarine avalanches. The coupled model is discretized using a positivity-preserving second-order path-conservative finite volume scheme. The data assimilation problem is posed in a global optimization framework and we develop and compare parallel metaheuristic stochastic global optimization algorithms, more precisely multi-path versions of the Simulated Annealing algorithm, with hybrid global optimization algorithms based on hybridizing Simulated Annealing with gradient local searchers, like L-BGFS-B.

Published
2024
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7. Computational approaches to Explainable Artificial Intelligence: Advances in theory, applications and trends

Author

Górriz, J.M., Álvarez-Illán, I., Álvarez-Marquina, A., Arco, J.E., Atzmueller, M., Ballarini, F., Barakova, E., Bologna, G., Bonomini, P., Castellanos-Dominguez, G., Castillo-Barnes, D., Cho, S.B., Contreras, R., Cuadra, J.M., Domínguez, E., Domínguez-Mateos, F., Duro, R.J., Elizondo, D., Fernández-Caballero, A., Fernandez-Jover, E., Formoso, M.A., Gallego-Molina, N.J., Gamazo, J., González, J. García, Garcia-Rodriguez, J., Garre, C., Garrigós, J., Gómez-Rodellar, A., Gómez-Vilda, P., Graña, M., Guerrero-Rodriguez, B., Hendrikse, S.C.F., Jimenez-Mesa, C., Jodra-Chuan, M., Julian, V., Kotz, G., Kutt, K., Leming, M., de Lope, J., Macas, B., Marrero-Aguiar, V., Martinez, J.J., Martinez-Murcia, F.J., Martínez-Tomás, R., Mekyska, J., Nalepa, G.J., Novais, P., Orellana, D., Ortiz, A., Palacios-Alonso, D., Palma, J., Pereira, A., Pinacho-Davidson, P., Pinninghoff, M.A., Ponticorvo, M., Psarrou, A., Ramírez, J., Rincón, M., Rodellar-Biarge, V., Rodríguez-Rodríguez, I., Roelofsma, P.H.M.P., Santos, J., Salas-Gonzalez, D., Salcedo-Lagos, P., Segovia, F., Shoeibi, A., Silva, M., Simic, D., Suckling, J., Treur, J., Tsanas, A., Varela, R., Wang, S.H., Wang, W., Zhang, Y.D., Zhu, H., Zhu, Z., and Ferrández-Vicente, J.M.

Published
2023
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10. Androgen deprivation therapy in patients with localized disease: Comparison with curative intent treatments and time to castration resistance. Results of the Spanish Prostate Cancer Registry

Author

Pórtela, P., Blanco, E., González, J.A., Baena, V., Morales, P., Villavicencio, H., Palou, J., Loizaga, A., Ciudin, A., Mihai, D., Martínez Jabaloyas, J.M., Castelló, A., Díez, N., Romero, F.J., Subirá, J., Chávez, A.I., Capapé, V., Mata, M., Elizalde, J., Lobato, J.J., Jiménez, J., Pérez Llorca, L., Tenza, J.A., Herranz, F., Husillos, A., López, E., Ramírez, D., Blaha, I., Izquierdo, E., Reina, L., Passas, J., Díez, L., Hevia, M.A., Castells, M., Concepción Masip, T., Plata, A.C., Asuar Aydillo, S., Alonso, J., Mateos, J., Carballido, J., Martínez, C., Areche, J., Rodríguez, R., Hevia, V., Álvarez, S., Requena, M.J., Prieto, R., Carazo, J.L., Márquez, J., Gómez, E., García, J.H., Amón, J., Cepeda, M., Álvarez, L., Rodríguez, V., de la Cruz, B., Rivero, A., Sánchez, J.F., Mainez, J.A., Medina, R., Conde, M., Castiñeiras, J., González Baena, A.C., Sánchez, E., Campanario, R., Saiz, R., Romero, E., Morote, J., Raventós, C.X., Celma, A., Vázquez, F., Gómez, A., Buendía, E., García, N., Garcia-Rodriguez, J., Fernandez-Gomez, J.M., Cozar, J.M., Miñana, B., Gomez-Veiga, F., and Rodriguez-Antolin, A.

Published
2020
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11. Terapia de privación de andrógenos en pacientes con enfermedad localizada: comparación de las opciones de tratamiento y tiempo hasta la resistencia a la castración. Resultados del Registro Español de Cáncer de Próstata

Author

Pórtela, P., Blanco, E., González, J.A., Baena, V., Morales, P., Villavicencio, H., Palou, J., Loizaga, A., Ciudin, A., Mihai, D., Martínez Jabaloyas, J.M., Castelló, A., Díez, N., Romero, F.J., Subirá, J., Chávez, A.I., Capapé, V., Mata, M., Elizalde, J., Lobato, J.J., Jiménez, J., Pérez Llorca, L., Tenza, J.A., Herranz, F., Husillos, A., López, E., Ramírez, D., Blaha, I., Izquierdo, E., Reina, L., Passas, J., Díez, L., Hevia, M.A., Castells, M., Concepción Masip, T., Plata, A.C., Asuar Aydillo, S., Alonso, J., Mateos, J., Carballido, J., Martínez, C., Areche, J., Rodríguez, R., Hevia, V., Álvarez, S., Requena, M.J., Prieto, R., Carazo, J.L., Márquez, J., Gómez, E., García, J.H., Amón, J., Cepeda, M., Álvarez, L., Rodríguez, V., de la Cruz, B., Rivero, A., Sánchez, J.F., Mainez, J.A., Medina, R., Conde, M., Castiñeiras, J., González Baena, A.C., Sánchez, E., Campanario, R., Saiz, R., Romero, E., Morote, J., Raventós, C.X., Celma, A., Vázquez, F., Gómez, A., Buendía, E., García, N., Garcia-Rodriguez, J., Fernandez-Gomez, J.M., Cozar, J.M., Miñana, B., Gomez-Veiga, F., and Rodriguez-Antolin, A.

Published
2020
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19. Computational approaches to Explainable Artificial Intelligence:Advances in theory, applications and trends

Author

Górriz, J. M., Álvarez-Illán, I., Álvarez-Marquina, A., Arco, J. E., Atzmueller, M., Ballarini, F., Barakova, E., Bologna, G., Bonomini, P., Castellanos-Dominguez, G., Castillo-Barnes, D., Cho, S. B., Contreras, R., Cuadra, J. M., Domínguez, E., Domínguez-Mateos, F., Duro, R. J., Elizondo, D., Fernández-Caballero, A., Fernandez-Jover, E., Formoso, M. A., Gallego-Molina, N. J., Gamazo, J., González, J. García, Garcia-Rodriguez, J., Garre, C., Garrigós, J., Gómez-Rodellar, A., Gómez-Vilda, P., Graña, M., Guerrero-Rodriguez, B., Hendrikse, S. C.F., Jimenez-Mesa, C., Jodra-Chuan, M., Julian, V., Kotz, G., Kutt, K., Leming, M., de Lope, J., Macas, B., Marrero-Aguiar, V., Martinez, J. J., Martinez-Murcia, F. J., Martínez-Tomás, R., Mekyska, J., Nalepa, G. J., Novais, P., Orellana, D., Ortiz, A., Palacios-Alonso, D., Palma, J., Pereira, A., Pinacho-Davidson, P., Pinninghoff, M. A., Ponticorvo, M., Psarrou, A., Ramírez, J., Rincón, M., Rodellar-Biarge, V., Rodríguez-Rodríguez, I., Roelofsma, P. H.M.P., Santos, J., Salas-Gonzalez, D., Salcedo-Lagos, P., Segovia, F., Shoeibi, A., Silva, M., Simic, D., Suckling, J., Treur, J., Tsanas, A., Varela, R., Wang, S. H., Wang, W., Zhang, Y. D., Zhu, H., Zhu, Z., Ferrández-Vicente, J. M., Górriz, J. M., Álvarez-Illán, I., Álvarez-Marquina, A., Arco, J. E., Atzmueller, M., Ballarini, F., Barakova, E., Bologna, G., Bonomini, P., Castellanos-Dominguez, G., Castillo-Barnes, D., Cho, S. B., Contreras, R., Cuadra, J. M., Domínguez, E., Domínguez-Mateos, F., Duro, R. J., Elizondo, D., Fernández-Caballero, A., Fernandez-Jover, E., Formoso, M. A., Gallego-Molina, N. J., Gamazo, J., González, J. García, Garcia-Rodriguez, J., Garre, C., Garrigós, J., Gómez-Rodellar, A., Gómez-Vilda, P., Graña, M., Guerrero-Rodriguez, B., Hendrikse, S. C.F., Jimenez-Mesa, C., Jodra-Chuan, M., Julian, V., Kotz, G., Kutt, K., Leming, M., de Lope, J., Macas, B., Marrero-Aguiar, V., Martinez, J. J., Martinez-Murcia, F. J., Martínez-Tomás, R., Mekyska, J., Nalepa, G. J., Novais, P., Orellana, D., Ortiz, A., Palacios-Alonso, D., Palma, J., Pereira, A., Pinacho-Davidson, P., Pinninghoff, M. A., Ponticorvo, M., Psarrou, A., Ramírez, J., Rincón, M., Rodellar-Biarge, V., Rodríguez-Rodríguez, I., Roelofsma, P. H.M.P., Santos, J., Salas-Gonzalez, D., Salcedo-Lagos, P., Segovia, F., Shoeibi, A., Silva, M., Simic, D., Suckling, J., Treur, J., Tsanas, A., Varela, R., Wang, S. H., Wang, W., Zhang, Y. D., Zhu, H., Zhu, Z., and Ferrández-Vicente, J. M.

Abstract

Deep Learning (DL), a groundbreaking branch of Machine Learning (ML), has emerged as a driving force in both theoretical and applied Artificial Intelligence (AI). DL algorithms, rooted in complex and non-linear artificial neural systems, excel at extracting high-level features from data. DL has demonstrated human-level performance in real-world tasks, including clinical diagnostics, and has unlocked solutions to previously intractable problems in virtual agent design, robotics, genomics, neuroimaging, computer vision, and industrial automation. In this paper, the most relevant advances from the last few years in Artificial Intelligence (AI) and several applications to neuroscience, neuroimaging, computer vision, and robotics are presented, reviewed and discussed. In this way, we summarize the state-of-the-art in AI methods, models and applications within a collection of works presented at the 9th International Conference on the Interplay between Natural and Artificial Computation (IWINAC). The works presented in this paper are excellent examples of new scientific discoveries made in laboratories that have successfully transitioned to real-life applications.

Published
2023

22. Computational Approaches to Explainable Artificial Intelligence: Advances Intheory, Applications and Trends

Author

Górriz, Juan Manuel, primary, Álvarez-Illán, I., additional, Álvarez-Marquina, A., additional, Arcoa, J.E., additional, Atzmueller, M., additional, Ballarini, F., additional, Barakova, E., additional, Bologna, G., additional, Bonomini, P., additional, Castellanos-Dominguez, G., additional, Castillo-Barnes, D., additional, Cho, S.B., additional, Contreras, R., additional, Cuadra, J.M., additional, Domínguez, E., additional, Domínguez-Mateos, F., additional, Duro, R.J., additional, Elizondo, D., additional, Fernández-Caballero, A., additional, Fernandez-Jover, E., additional, Formoso, M.A., additional, Gallego-Molina, N.J., additional, Gamazo, J., additional, González, J. García, additional, Garcia-Rodriguez, J., additional, Garre, C., additional, Garrigós, J., additional, Gómez-Rodellar, A., additional, Gómez-Vilda, P., additional, Graña, M., additional, Guerrero-Rodriguez, B., additional, Hendrikse, S. C. F., additional, Jimenez-Mesa, C., additional, Jodra-Chuan, M., additional, Julian, V., additional, Kotz, G., additional, Kutt, K., additional, Leming, M., additional, Lope, J. de, additional, Macas, B., additional, Marrero-Aguiar, V., additional, Martinez, J.J., additional, Martinez-Murcia, F.J., additional, Martínez-Tomás, R., additional, Mekyska, J., additional, Nalepa, G.J., additional, Novais, P., additional, Orellana, D., additional, Ortiz, A., additional, Palacios-Alonso, D., additional, Palma, J., additional, Pereira, A., additional, Pinacho-Davidson, P., additional, Pinninghof, M.A., additional, Ponticorvo, M., additional, Psarrou, A., additional, Ramírez, J., additional, Rincón, M., additional, Rodellar-Biarge, V., additional, Rodríguez-Rodríguez, I., additional, Roelofsma, P. H.M.P., additional, Santos, J., additional, Salas-Gonzalez, D., additional, Salcedo-Lagos, P., additional, Segovia, F., additional, Shoeibi, A., additional, Silva, M., additional, Simic, D., additional, Suckling, J., additional, Treur, J., additional, Tsanas, Athanasios, additional, Varela, R., additional, Wang, SH., additional, Wang, W., additional, Zhang, YD., additional, Zhu, H., additional, Zhu, Z., additional, and Ferrández-Vicente, J.M., additional

Published
2023
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28. Early Stepdown From Echinocandin to Fluconazole Treatment in Candidemia: A Post Hoc Analysis of Three Cohort Studies (vol 8, ofab250, 2021)

Author

Moreno-Garcia, E., Puerta-Alcalde, P., Gariup, G., Fernandez-Ruiz, M., Lopez Cortes, L. E., Cuervo, G., Salavert, M., Merino, P., Machado, M., Guinea, J., Garcia-Rodriguez, J., Garnacho-Montero, J., Cardozo, C., Peman, J., Montejo, M., Fortun, J., Almirante, B., Castro, C., Rodriguez-Bano, J., Aguado, J. M., Martinez, J. A., Carratala, J., Soriano, A., and Garcia-Vidal, C.

Abstract

[This corrects the article DOI: 10.1093/ofid/ofab250.].

Published
2022

29. Impact of fluconazole susceptibility on the outcome of patients with candidaemia: data from a population-based surveillance

Author

Padilla, B., Muñoz, P., Guinea, J., Paño Pardo, J.R., García-Rodríguez, J., Cerrada, C.G., Fortún, J., Martín, P., Gómez, E., Ryan, P., Campelo, C., de los Santos Gil, I., Buendía, V., Gorricho, B.P., Alonso, M., Sanz, F.S., Aguado, J.M., Merino, P., González Romo, F., Gorgolas, M., Gadea, I., Losa, J.E., Delgado-Iribarren, A., Ramos, A., Romero, Y., Romero, I.S., Zaragoza, O., Cuenca-Estrella, M., Rodríguez-Baño, J., Suarez, A.I., Loza, A., Aller García, A.I., Martín-Mazuelos, E., Pérez de Pipaón, M.R., Garnacho, J., Ortiz, C., Chávez, M., Maroto, F.L., Salavert, M., Pemán, J., Blanquer, J., Navarro, D., Camarena, J.J., Zaragoza, R., Abril, V., Gimeno, C., Hernández, S., Ezpeleta, G., Bereciartua, E., Hernández Almaraz, J.L., Montejo, M., Rivas, R.A., Ayarza, R., Planes, A.M., Camps, I.R., Almirante, B., Mensa, J., Almela, M., Gurgui, M., Sánchez-Reus, F., Martínez-Montauti, J., Sierra, M., Horcajada, J.P., Sorli, L., Gómez, J., Gené, A., Urrea, M., Mularoni, A., Valerio, M., Díaz-Martín, A., Puchades, F., Fernández-Ruiz, M., Lora-Pablos, D., Zaragoza, Ó., and Puig-Asensio, M.

Published
2017
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30. Evaluation of the possible influence of trailing and paradoxical effects on the clinical outcome of patients with candidemia

Author

Padilla, B., Muñoz, P., Guinea, J., Paño Pardo, J.R., García-Rodríguez, J., García Cerrada, C., Fortún, J., Martín, P., Gómez, E., Ryan, P., Campelo, C., de los Santos Gil, I., Buendía, V., Gorricho, B.P., Alonso, M., Sanz, F.S., Aguado, J.M., Merino, P., González Romo, F., Gorgolas, M., Gadea, I., Losa, J.E., Delgado-Iribarren, A., Ramos, A., Romero, Y., Sánchez Romero, I., Zaragoza, O., Cuenca-Estrella, M., Rodriguez-Baño, J., Isabel Suarez, A., Loza, A., Aller García, A.I., Martín-Mazuelos, E., Pérez de Pipaón, M.R., Garnacho, J., Ortiz, C., Chávez, M., Maroto, F.L., Salavert, M., Pemán, J., Blanquer, J., Navarro, D., Camarena, J.J., Zaragoza, R., Abril, V., Gimeno, C., Hernáez, S., Ezpeleta, G., Bereciartua, E., Hernández Almaraz, J.L., Montejo, M., Rivas, R.A., Ayarza, R., Planes, A.M., Camps, I.R., Almirante, B., Mensa, J., Almela, M., Gurgui, M., Sánchez-Reus, F., Martinez-Montauti, J., Sierra, M., Horcajada, J.P., Sorli, L., Gómez, J., Gené, A., Urrea, M., Valerio, M., Díaz-Martín, A., Puchades, F., Mularoni, A., Rueda, C., and Puig-Asensio, M.

Published
2017
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39. Empirical and targeted therapy of candidemia with fluconazole versus echinocandins: a propensity score–derived analysis of a population-based, multicentre prospective cohort

Author

Padilla, B., Muñoz, P., Guinea, J., Paño Pardo, J.R., García-Rodríguez, J., García Cerrada, C., Fortún, J., Martín, P., Gómez, E., Ryan, P., Campelo, C., de los Santos Gil, I., Buendía, V., Pérez Gorricho, B., Alonso, M., Sanz Sanz, F., María Aguado, J., Merino, P., González Romo, F., Gorgolas, M., Gadea, I., Losa, J.E., Delgado-Iribarren, A., Ramos, A., Romero, Y., Sánchez Romero, I., Zaragoza, O., Cuenca-Estrella, M., Rodríguez-Baño, J., Suarez, A.I., Loza, A., Aller García, A.I., Martín-Mazuelos, E., Pérez de Pipaón, M.R., Garnacho, J., Ortiz, C., Chávez, M., Maroto, F.L., Salavert, M., Pemán, J., Blanquer, J., Navarro, D., Camarena, J.J., Zaragoza, R., Abril, V., Gimeno, C., Hernáez, S., Ezpeleta, G., Bereciartua, E., Hernández Almaraz, J.L., Montejo, M., Rivas, R.A., Ayarza, R., Planes, A.M., Ruiz Camps, I., Almirante, B., Mensa, J., Almela, M., Gurgui, M., Sánchez-Reus, F., Martinez-Montauti, J., Sierra, M., Horcajada, J.P., Sorli, L., Gómez, J., Gené, A., Urrea, M., Valerio, M., Díaz-Martín, A., Puchades, F., Mularoni, A., López-Cortés, L.E., Garnacho-Montero, J., Puig-Asensio, M., and Ruiz-Camps, I.

Published
2016
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40. Multinational evaluation of the BioFire® FilmArray® Pneumonia plus Panel as compared to standard of care testing

Author

Ginocchio, C. C., Garcia-Mondragon, C., Mauerhofer, B., Rindlisbacher, C., Forcelledo, L., Fernandez, J., Lienhard, R., Kerschner, H., Rossolini, G. M., Armand-Lefevre, L., D'Humieres, C., Cambau, E., Benmansour, H., Cavallo, R., Altwegg, M., Berlinger, L., Bonnet, R., Saint-Sardos, P., Meex, C., Lavigne, J. P., Leveque, N., Broutin, L., Cattoir, V., Auger, G., Pereira, H., Paitan, Y., Verroken, A., Pailhories, H., Lemarie, C., Martinetti-Lucchini, G., Frigerio Malossa, S., Sanguinetti, M., Spanu, T., Vandenesch, F., Poyart, C., Loubinoux, J., Mira, J. P., Bonacorsi, S., Cointe, A., Munoz, P., Kestler, M., Esteva, C., Queralt, X., Garcia-Rodriguez, J., Gomez, M. D., Lopez-Hontangas, J. L., Ghisetti, V., Burdino, E., Schubert, S., Mencacci, A., Allegrucci, F., Rozemeijer, W., Paternotte, N., Allard, A., M. C., Re, Ambretti, S., Skov, M., Agergaard, C. N., Subudhi, P., Wichelhaus, T. A., Egli, A., Hinic, V., Alcock, A., Banavathi, K., Tiberio, C., Ruocco, G., and Atripaldi, L.

Subjects
0301 basic medicine, Microbiology (medical), Veterinary medicine, Standard of care, Atypical bacteria, 030106 microbiology, 03 medical and health sciences, 0302 clinical medicine, Anti-Infective Agents, Diagnosis, otorhinolaryngologic diseases, Humans, Medicine, 030212 general & internal medicine, Israel, BioFire Pneumonia plus Panel, Bacteria, business.industry, Standard of Care, Pneumonia, HAP, General Medicine, medicine.disease, CAP, Highly sensitive, Europe, Infectious Diseases, Molecular Diagnostic Techniques, Viruses, VAP, Original Article, Detection rate, business
Abstract

This study compared standard of care testing (SOC) to BioFire® FilmArray® Pneumonia plus Panel (PNplus). PNplus detects 15 bacteria with semiquantitative log bin values, 7 antibiotic resistance markers, three atypical bacteria (AB), and eight viral classes directly from bronchoalveolar lavage-like specimens (BLS) and sputum-like specimens (SLS). Fifty-two laboratories from 13 European countries and Israel tested 1234 BLS and 1242 SLS with PNplus and SOC. Detection rates and number of pathogens/samples were compared for PNplus pathogens. PNplus bin values and SOC quantities were compared. Three thousand two hundred sixty-two bacteria in PNplus were detected by PNplus and/or SOC. SOC detected 57.1% compared to 95.8% for PNplus (p ≤ 0.0001). PNplus semiquantitative bin values were less than SOC, equal to SOC, or greater than SOC in 5.1%, 25.4%, and 69.6% of results, respectively. PNplus bin values were on average ≥ 1 log than SOC values (58.5% 1–2 logs; 11.0% 3–4 logs). PNplus identified 98.2% of MRSA and SOC 55.6%. SOC detected 73/103 AB (70.9%) and 134/631 viruses (21.2%). PNplus detected 93/103 AB (90.3%) and 618/631 viruses (97.9%) (p ≤ 0.0001). PNplus and SOC mean number of pathogens/samples were 1.99 and 1.44, respectively. All gram-negative resistance markers were detected. PNplus and SOC results were fully or partially concordant for 49.1% and 26.4% of specimens, respectively. PNplus was highly sensitive and detected more potential pneumonia pathogens than SOC. Semiquantification may assist in understanding pathogen significance. As PNplus generates results in approximately 1 h, PNplus has potential to direct antimicrobial therapy in near real time and improve antimicrobial stewardship and patient outcomes.

Published
2021
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42. BLACK HOLE PHYSICS: Black hole lightning due to particle acceleration at subhorizon scales

Author

Aleksić, J., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Bangale, P., Barrio, J. A., González, Becerra J., Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Caneva, G., De Lotto, B., de Oña Wilhelmi, E., Mendez, Delgado C., Prester, Dominis D., Dorner, D., Doro, M., Einecke, S., Eisenacher, D., Elsaesser, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., López, García R. J., Garczarczyk, M., Terrats, Garrido D., Gaug, M., Godinović, N., Muñoz, González A., Gozzini, S. R., Hadasch, D., Hanabata, Y., Hayashida, M., Herrera, J., Hildebrand, D., Hose, J., Hrupec, D., Idec, W., Kadenius, V., Kellermann, H., Kodani, K., Konno, Y., Krause, J., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lewandowska, N., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., López-Oramas, A., Lorenz, E., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Munar-Adrover, P., Nakajima, D., Niedzwiecki, A., Nilsson, K., Nishijima, K., Noda, K., Orito, R., Overkemping, A., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes-Fortuny, X., Persic, M., Poutanen, J., Moroni, Prada P. G., Prandini, E., Puljak, I., Reinthal, R., Rhode, W., Ribó, M., Rico, J., Garcia, Rodriguez J., Rügamer, S., Saito, T., Saito, K., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shore, S. N., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Spanier, F., Stamatescu, V., Stamerra, A., Steinbring, T., Storz, J., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Thaele, J., Tibolla, O., Torres, D. F., Toyama, T., Treves, A., Uellenbeck, M., Vogler, P., Zanin, R., Kadler, M., Schulz, R., Ros, E., Bach, U., Krau, F., and Wilms, J.

Published
2014
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43. Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000–2015

Author

Perez-Nadales E, Alastruey-Izquierdo A, Linares-Sicilia M, Soto-Debran J, Abdala E, Garcia-Rodriguez J, Montejo M, Munoz P, Lleti M, Rezusta A, de Pipaon M, Yanez L, Merino E, Campos-Herrero M, Costa-Mateo J, Fortun J, Garcia-Lozano T, Garcia-Vidal C, Fernandez-Ruiz M, Sanchez-Reus F, Castro-Mendez C, Guerrero-Lozano I, Soler-Palacin P, Aguado J, Martinez-Martinez L, Torre-Cisneros J, Nucci M, Spanish Fusariosis Study Grp, Biomedicina, Biotecnología y Salud Pública, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Red Española de Investigación en Patología Infecciosa, European Regional Development Fund, and European Regional Development Fund (ERDF/FEDER)

Subjects
Antifungal Agents, Epidemiology, fusariosis, lcsh:Medicine, HEMATOLOGIC MALIGNANCIES, Fusarium, CME, health care economics and organizations, Neutropènia, musculoskeletal, neural, and ocular physiology, Mortality rate, Incidence (epidemiology), Observational Studies as Topic, Infectious Diseases, fungal infections, DISEASES, Synopsis, Microbiology (medical), Fusariosis, medicine.medical_specialty, Neutropenia, education, Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000–2015, macromolecular substances, lcsh:Infectious and parasitic diseases, FUNGAL-INFECTIONS, Internal medicine, medicine, Mortalitat, Humans, lcsh:RC109-216, Risk factor, Mortality, Epidemiologia, Proportional hazards model, business.industry, lcsh:R, Retrospective cohort study, invasive fusariosis, MASS-SPECTROMETRY, medicine.disease, mortality, CELL TRANSPLANT RECIPIENTS, mycotic diseases, nervous system, Spain, incidence, fungi, business
Abstract

Invasive fusariosis has a global increasing incidence and has emerged as a severe infection in nonneutropenic patients., Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000–2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000–2009 to 0.22 cases per 100,000 admissions in 2010–2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy.

Published
2021

44. Mixinyeast: A multicenter study on mixed yeast infections

Author

Medina, N. Soto-Debrán, J.C. Seidel, D. Akyar, I. Badali, H. Barac, A. Bretagne, S. Cag, Y. Cassagne, C. Castro, C. Chakrabarti, A. Dannaoui, E. Cardozo, C. Garcia-Rodriguez, J. Guitard, J. Hamal, P. Hoenigl, M. Jagielski, T. Khodavaisy, S. Lo Cascio, G. Martínez-Rubio, M.C. Meletiadis, J. Muñoz, P. Ochman, E. Peláez, T. Balzola, A.P.-A. Prattes, J. Roilides, E. de Pipaón, M.R.-P. Stauf, R. Steinmann, J. Suárez-Barrenechea, A.I. Tejero, R. Trovato, L. Viñuela, L. Wongsuk, T. Żak, I. Zarrinfar, H. Lass-Flörl, C. Arikan-Akdagli, S. Alastruey-Izquierdo, A.

Abstract

Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epi-demiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe ac-counted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were Candida albicans/C. glabrata (42, 34.4%), C. albicans/C. parapsilosis (17, 14%), and C. glabrata/C. tropicalis (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions. © 2020 by the authors. Li-censee MDPI, Basel, Switzerland.

Published
2021

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