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Inhibition of the receptor tyrosine kinase MerTK by small molecules has the potential to augment the immune response to tumors. Potent, selective inhibitors with high levels of in vivotarget engagement are needed to fully evaluate the potential use of MerTK inhibitors as cancer therapeutics. We report the discovery and optimization of a series of pyrazinamide-based type 1.5 MerTK inhibitors bearing an azetidine-benzoxazole substituent. Compound 31potently engages the target in vivoand demonstrates single agent activity in the immune-driven MC-38 murine syngeneic tumor model.

Changes in the nation's social climate, the proliferation of different consumer life styles, and changing the consumer needs and expectations explain a good deal about the evolution of store formats-but not all of it. Technological, economic, and competitive factors also play a role. Fortunately, marketing theory provides a number of useful analytical tools for tying these factors together, and this can lead to a better understanding of food retailing's past-as well as future.

The author comments on articles by Ed Offley and J.B. Bryant about the sinking of the submarine USS Scorpion on May 22, 1968 and the effort of the U.S. Navy to cover up the involvement of the Soviet Union, that was previously published in the journal. The author refutes Offley's claim that an Echo II class Soviet submarine had actually torpedoed Scorpion. The author points to photographic coverage of the Scorpion wreck which shows no structural damage consistent with explosion of a torpedo.