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1. Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging

Author

Peskind, Elaine R., Raskind, Murray A., Wingerson, Dane, Pascualy, Marcella, Thal, Leon J., Dobie, Dorcas J., Veith, Richard C., Dorsa, Daniel M., Murray, Sharon, Sikkema, Carl, Galt, Stephen A., and Wilkinson, Charles W.

Subjects
Hypothalamic-pituitary-adrenal axis -- Research, Aging -- Physiological aspects, Physostigmine -- Physiological aspects, Health, Seniors
Abstract

A comparative study of the pharmacologic responses of hypothalamic-pituitary-adrenocortical (HPA) axis to physostigmine, a cholinesterase inhibitor, in younger and older adults indicates that aging enhances HPA axis response to physostigmine. There is no variation in the levels of physostigmine in the plasma due to aging.

Published
1995

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