2,859 results on '"Galli, C."'
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2. Dementia
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Galli, C.
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This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.
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- 2020
3. How long does it take to diagnose young-onset dementia? A comparison with late-onset dementia
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Chiari, A., Tondelli, M., Galli, C., Carbone, C., Fiondella, L., Salemme, S., Vinceti, G., Bedin, R., Molinari, M. A., and Zamboni, G.
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- 2022
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4. The ART of bringing extinction to a freeze – History and future of species conservation, exemplified by rhinos
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Hildebrandt, Thomas B., Hermes, Robert, Goeritz, Frank, Appeltant, Ruth, Colleoni, Silvia, de Mori, Barbara, Diecke, Sebastian, Drukker, Micha, Galli, C., Hayashi, K., Lazzari, G., Loi, Pasqualino, Payne, J., Renfree, Marilyn, Seet, Steven, Stejskal, Jan, Swegen, A., Williams, Suzannah A., Zainuddin, Zainal Zahari, and Holtze, Susanne
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- 2021
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5. Serological diagnosis and prevalence of HIV-1 infection in Russian metropolitan areas
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Kireev, D. E., Chulanov, V. P., Shipulin, G. A., Semenov, A. V., Tivanova, E. V., Kolyasnikova, N. M., Zueva, E. B., Pokrovskiy, V. V., and Galli, C.
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- 2021
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6. Incomplete penetrance in familial Alzheimer’s disease with PSEN1 Ala260Gly mutation
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Piaceri, I., Chiari, A., Galli, C., Bagnoli, S., Ferrari, C., Saavedra, S. Trujillo, Molinari, M. A., Vinceti, G., Sorbi, S., and Nacmias, B.
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- 2020
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7. Optical modulation of excitation-contraction coupling in human-induced pluripotent stem cell-derived cardiomyocytes
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Vurro, V, Federici, B, Ronchi, C, Florindi, C, Sesti, V, Crasto, S, Maniezzi, C, Galli, C, Antognazza, M, Bertarelli, C, Di Pasquale, E, Lanzani, G, Lodola, F, Vurro V., Federici B., Ronchi C., Florindi C., Sesti V., Crasto S., Maniezzi C., Galli C., Antognazza M. R., Bertarelli C., Di Pasquale E., Lanzani G., Lodola F., Vurro, V, Federici, B, Ronchi, C, Florindi, C, Sesti, V, Crasto, S, Maniezzi, C, Galli, C, Antognazza, M, Bertarelli, C, Di Pasquale, E, Lanzani, G, Lodola, F, Vurro V., Federici B., Ronchi C., Florindi C., Sesti V., Crasto S., Maniezzi C., Galli C., Antognazza M. R., Bertarelli C., Di Pasquale E., Lanzani G., and Lodola F.
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Non-genetic photostimulation is a novel and rapidly growing multidisciplinary field that aims to induce light-sensitivity in living systems by exploiting exogeneous phototransducers. Here, we propose an intramembrane photoswitch, based on an azobenzene derivative (Ziapin2), for optical pacing of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The light-mediated stimulation process has been studied by applying several techniques to detect the effect on the cell properties. In particular, we recorded changes in membrane capacitance, in membrane potential (Vm), and modulation of intracellular Ca2+ dynamics. Finally, cell contractility was analyzed using a custom MATLAB algorithm. Photostimulation of intramembrane Ziapin2 causes a transient Vm hyperpolarization followed by a delayed depolarization and action potential firing. The observed initial electrical modulation nicely correlates with changes in Ca2+ dynamics and contraction rate. This work represents the proof of principle that Ziapin2 can modulate electrical activity and contractility in hiPSC-CMs, opening up a future development in cardiac physiology.
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- 2023
8. The Response of Osteoblasts and Bone to Sinusoidal Electromagnetic Fields: Insights from the Literature
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Galli, C., Colangelo, M., Pedrazzi, G., and Guizzardi, S.
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- 2019
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9. Precision genetics for complex objectives in animal agriculture
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Fahrenkrug, SC, Blake, A, Carlson, DF, Doran, T, Van Eenennaam, A, Faber, D, Galli, C, Gao, Q, Hackett, PB, Li, N, Maga, EA, Muir, WM, Murray, JD, Shi, D, Stotish, R, Sullivan, E, Taylor, JF, Walton, M, Wheeler, M, Whitelaw, B, and Glenn, BP
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Genetics ,Zero Hunger ,Animal Husbandry ,Animal Welfare ,Animals ,Animals ,Domestic ,Animals ,Genetically Modified ,Food ,Food Microbiology ,Food Supply ,Genetic Engineering ,Genetic Techniques ,Humans ,Nutritional Status ,cross-breeding ,genetic engineering ,genetic technology ,hybridization ,phenotypic diversity ,selection ,Biological Sciences ,Agricultural and Veterinary Sciences ,Dairy & Animal Science - Abstract
Indirect modification of animal genomes by interspecific hybridization, cross-breeding, and selection has produced an enormous spectrum of phenotypic diversity over more than 10,000 yr of animal domestication. Using these established technologies, the farming community has successfully increased the yield and efficiency of production in most agricultural species while utilizing land resources that are often unsuitable for other agricultural purposes. Moving forward, animal well-being and agricultural sustainability are moral and economic priorities of consumers and producers alike. Therefore, these considerations will be included in any strategy designed to meet the challenges produced by global climate change and an expanding world population. Improvements in the efficiency and precision of genetic technologies will enable a timely response to meet the multifaceted food requirements of a rapidly increasing world population.
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- 2010
10. A cytotoxicity study of silicon oxycarbide nanowires as cell scaffold for biomedical applications
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Lagonegro, P., Rossi, F., Galli, C., Smerieri, A., Alinovi, R., Pinelli, S., Rimoldi, T., Attolini, G., Macaluso, G., Macaluso, C., Saddow, S.E., and Salviati, G.
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- 2017
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11. SCCS OPINION on water-soluble zinc salts used in oral hygiene products - Submission II - SCCS/1657/23 - Preliminary version
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Benfentati, E., Cabaton, N., Corsini, E., Koutsodimou, A., Louro, H., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)
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SCCS ,zinc acetate CAS: 557-34-6 EC: 209-170-2 ,zinc chloride CAS: 7646-85-7 EC: 231-592-0 ,zinc gluconate CAS: 4468-02-4 EC ,Regulation 1223/2009 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,water-soluble zinc salts ,zinc sulphate/zinc sulphate monohydrate/zinc sulphate heptahydrate CAS: 7733-02-0/7446-19-7/7446-20-0 EC ,oral hygiene products ,zinc citrate CAS: 546-46-3 EC ,SCCS/1586/17 ,scientific opinion - Abstract
International audience; SCCS OPINION on water-soluble zinc salts used in oral hygiene products - Submission II - SCCS/1657/23 - Preliminary versionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzThe SCCS adopted this Opinion by written procedure on 3 July 2023 (23 pages)Mise en ligne : 4 July 2023https://health.ec.europa.eu/publications/water-soluble-zinc-salts-used-oral-hygiene-products-submission-ii_enhttps://health.ec.europa.eu/system/files/2023-07/sccs_o_279.pdfDetailsPublication date : 4 July 2023Author : Scientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin (Rapporteur), Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzContact: SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1657/23Adopted on: 3 July 2023Conclusion of the opinion:In light of the data provided and taking under consideration the aggregate exposure (including diet) and the concerns on the Tolerable Daily Upper Intake,(1) Does the SCCS consider that water soluble zinc salts are safe up to 1 % (as zinc) in toothpaste and 0.1% (as zinc) in mouthwash, for both adults and children? If not, the SCCS is requested to provide safe concentrations for each age group.The SCCS has calculated aggregate exposure to water-soluble zinc salts via toothpaste at the concentrations of 1% and from diet and concluded that the use of zinc in toothpaste is safe per se except for children under the age of 1 year because the intake exceeds the upper limit level. For children up to 1 year of age, the SCCS recommends a safe concentration of 0.72% for soluble zinc salts (as zinc) in toothpaste.The inclusion of zinc in mouthwash at 0.1% Zn is considered safe across all age groups.(2) Does the SCCS consider that the contribution of the cosmetic products among the overall/total exposure to zinc is still of concern?/SCCS, scientific opinion, water-soluble zinc salts, oral hygiene products, zinc acetate CAS: 557-34-6 EC: 209-170-2, zinc chloride CAS: 7646-85-7 EC: 231-592-0, zinc gluconate CAS: 4468-02-4 EC:/, zinc citrate CAS: 546-46-3 EC:/, zinc sulphate/zinc sulphate monohydrate/zinc sulphate heptahydrate CAS: 7733-02-0/7446-19-7/7446-20-0 EC:/, SCCS/1586/17, Regulation 1223/2009Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on water-soluble zinc salts used in oral hygiene products - Submission II, preliminary version adopted on 3 July 2023, SCCS/1657/23.
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- 2023
12. SCCS OPINION on benzyl salicylate (CAS No. 118-58-1, EC No. 204-262-9) _ SCCS/1656/23– Preliminary Opinion
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Benfentati, E., Cabaton, N., Corsini, E., Koutsodimou, A., Louro, H., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,SCCS, scientific opinion, benzyl salicylate, Regulation 1223/2009, CAS No. 118-58-1, EC No. 204-262-9 - Abstract
International audience; SCCS OPINION on benzyl salicylate (CAS No. 118-58-1, EC No. 204-262-9) _ SCCS/1656/23– Preliminary OpinionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzThe SCCS adopted this document during its plenary meeting on 6-7 June 2023 2023 (68 Pages)Mise en ligne : 13 Juin 2023 https://health.ec.europa.eu/publications/benzyl-salicylate-cas-no-118-58-1-ec-no-204-262-9_enhttps://health.ec.europa.eu/system/files/2023-06/sccs_o_277.pdfDetailsPublication date : 13 June 2023Author : Scientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle (Rapporteur), M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: E. Benfentati, N. Cabaton (Rapporteur), E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzContact: SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1656/23Adopted on: 6-7 June 2023Conclusion of the opinion:(1) In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of Benzyl Salicylate, does the SCCS consider Benzyl Salicylate safe when used up to the maximum concentrations provided in the dossier submission by the Benzyl Salicylate Consortium?Based on the data provided and assessed and taking under consideration the concerns related to potential endocrine disrupting properties, the SCCS considers Benzyl Salicylate safe when used up to the maximum concentrations provided in Table 1 of this Opinion.(2) Alternatively, what is according to the SCCS the maximum concentration considered safe for use of Benzyl Salicylate in cosmetic products?/(3) Does the SCCS have any further scientific concerns with regard to the use of Benzyl Salicylate in cosmetic products?The available data on Benzyl Salicylate provide some indications for an endocrine mode of action, but there is no evidence that this results in potential endocrine effects.The SCCS mandates do not address environmental aspects. Therefore, this assessment did not cover the safety of Benzyl Salicylate for the environment.Keywords:SCCS, scientific opinion, benzyl salicylate, Regulation 1223/2009, CAS No. 118-58-1, EC No. 204-262-9Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on benzyl salicylate (CAS No. 118-58-1, EC No. 204-262-9), preliminary version of 6-7 June 2023, SCCS/1656/23.
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- 2023
13. SCCS OPINION on salicylic acid (CAS No. 69-72-7, EC No. 200-712-3) - SCCS/1646/22– Final Opiinion
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Benfentati, E., Cabaton, N., Corsini, E., Koutsodimou, A., Louro, H., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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SCCS ,Regulation 1223/2009 ,salicylic acid ,CAS No. 69-72-7 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,EC No. 200-712-3 ,scientific opinion - Abstract
International audience; SCCS OPINION on salicylic acid (CAS No. 69-72-7, EC No. 200-712-3) - SCCS/1646/22– Final OpiinionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzThe SCCS adopted this document at its plenary meeting on 6 June 2023 (75 Pages)Mise en ligne : 9 Juin 2023https://health.ec.europa.eu/publications/salicylic-acid-cas-no-69-72-7-ec-no-200-712-3_enhttps://health.ec.europa.eu/system/files/2023-06/sccs_o_268.pdfDetailsPublication date : 9 June 2023Author : Scientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli, E. Panteri (Rapporteur), V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: E. Benfenati, N. Cabaton (Rapporteur), E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzContact:SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1646/22Adopted on: 6-7 June 2023Conclusion of the opinion:(1) In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of Salicylic acid,a) does the SCCS consider Salicylic acid safe when used as a preservative in cosmetic products up to a maximum concentration of 0.5%?Based on the safety assessment carried out in consideration of all available information, including the potential endocrine effects:- the SCCS is of the opinion that salicylic acid (CAS 69-72-7) is safe when used as preservative at a concentration of 0.5 % in cosmetic products, considering its current restrictions in place. The provided information shows that salicylic acid is an eye irritant with the potential to cause serious damage to the eye.- this Opinion is not applicable to any sprayable product (including mouth spray) that may lead to exposure of end-user’s lungs by inhalation.b) does the SCCS consider Salicylic acid safe when used in cosmetic for purposes other than inhibiting the development of micro-organisms at a concentration up to:i. 3.0% for the cosmetic rinse-off hair products,ii. 2.0% for other products except body lotion, eye shadow, mascara, eyeliner, lipstick, non-spray deodorant, andiii. 0.5% for body lotion, eye shadow, mascara, eyeliner, lipstick, oral products and non-spray deodorantThe SCCS assessment has shown that:The use of salicylic acid as a restricted ingredient for purposes other than inhibiting the development of micro-organisms is safe at a concentration:- up to 3.0 % for the cosmetic rinse-off hair products,- up to 2.0 % for other products, except body lotion, eye shadow, mascara, eyeliner, lipstick, non-spray deodorant, and- up to 0.5% for body lotion, eye shadow, mascara, eyeliner, lipstick, oral products and non-spray deodorant.This Opinion is not applicable to any sprayable product (including mouth spray) that may lead to exposure of end-user’s lungs by inhalation.(2) Alternatively, what is according to the SCCS the maximum concentration considered safe for use of Salicylic acid in cosmetic products? / (3) Does the SCCS have any further scientific concerns with regard to the use of Salicylic acid in cosmetic products? In the absence of exposure data of Salicylic acid in cosmetic products for children, safety concerns have been noted for the younger age groups (between 3-10 years).Since the Cosmetic Regulation does not allow the use of salicylic acid in products for children under 3 years of age, this age category has not been considered in this Opinion.The conclusions of this Opinion refer only to Salicylic Acid as a cosmetic ingredient and not to other salicylates or salicylic acid salts.Keywords:SCCS, scientific opinion, salicylic acid, Regulation 1223/2009, CAS No. 69-72-7, EC No. 200-712-3Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on salicylic acid (CAS No. 69-72-7, EC No. 200-712-3), preliminary version of 14 December 2022, final version of 6-7 June 2023, SCCS/1646/22.
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- 2023
14. SCCS OPINION on Methylparaben (CAS No. 99-76-3, EC No. 202-785-7) - SCCS/1652/23– Preliminary Opinion
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Benfentati, E., Cabaton, N., Corsini, E., Koutsodimou, A., Louro, H., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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SCCS ,methylparaben ,Regulation 1223/2009 ,preservative ,EC No. 202-785-7 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,CAS No. 99-76-3 ,scientific opinion - Abstract
International audience; SCCS OPINION on Methylparaben (CAS No. 99-76-3, EC No. 202-785-7) - SCCS/1652/23– Preliminary OpinionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzThe SCCS adopted this document during its plenary meeting on 6-7 June 2023 2023 (95 pages)Mise en ligne : 8 Juin 2023https://health.ec.europa.eu/publications/methylparaben-cas-no-99-76-3-ec-no-202-785-7_enhttps://health.ec.europa.eu/system/files/2023-06/sccs_o_276.pdfDetailsPublication date : 8 June 2023Author : Scientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer (Rapporteur), L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam (Rapporteur), E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzContact: SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1652/23Adopted on: 6-7 June 2023Conclusion of the opinion:(1) In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of Methylparaben, does the SCCS consider Methylparaben safe when used as a preservative in cosmetic products up to a maximum concentration of 0.4% (as acid) when used on its own and up to 0.8% (as acid) for mixtures of esters as indicated in entry 12 of Annex V to the Cosmetics Regulation?On the basis of the safety assessment of Methylparaben, and considering the concerns related to potential endocrine activity, the SCCS has concluded that Methylparaben is safe when used as a preservative in cosmetic products up to a maximum concentration of 0.4% (as acid) when used on its own and up to 0.8% (as acid) for mixtures of esters as indicated in entry 12 of Annex V to the Cosmetics Regulation.(2) Alternatively, what is according to the SCCS the maximum concentration considered safe for use of Methylparaben as a preservative in cosmetic products?/(3) Does the SCCS have any further scientific concerns with regard to the use of Methylparaben in cosmetic products?The SCCS mandates do not address environmental aspects. Therefore, this assessment did not cover the safety of Methylparaben for the environment.Keywords:SCCS, scientific opinion, methylparaben, preservative, Regulation 1223/2009, CAS No. 99-76-3, EC No. 202-785-7Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on Methylparaben (CAS No. 99-76-3, EC No. 202-785-7), preliminary version of 6-7 June 2023, SCCS/1652/23.
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- 2023
15. SCCS OPINION on Butylparaben (CAS No. 94-26-8, EC No. 202-318-7) - SCCS/1651/23– Preliminary Opinion
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Benfentati, E., Cabaton, N., Corsini, E., Koutsodimou, A., Louro, H., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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SCCS ,Regulation 1223/2009 ,preservative ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,butylparaben ,EC No. 202-318-7 ,scientific opinion ,CAS No. 94-26-8 - Abstract
International audience; SCCS OPINION on Butylparaben (CAS No. 94-26-8, EC No. 202-318-7) - SCCS/1651/23– Preliminary OpinionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzThe SCCS adopted this document during its plenary meeting on 6-7 June 2023 2023 (136 pages)Mise en ligne : 8 Juin 2023https://health.ec.europa.eu/publications/butylparaben-cas-no-94-26-8-ec-no-202-318-7_enhttps://health.ec.europa.eu/system/files/2023-06/sccs_o_275.pdfDetailsPublication date : 8 June 2023Author : Scientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin (Rapporteur), Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers (Rapporteur), Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzContact: SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1651/23Adopted on: 6-7 June 2023Conclusion of the opinion:(1) In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of Butylparaben, does the SCCS consider Butylparaben safe when used as a preservative in cosmetic products up to a maximum concentration of 0.14 %?On the basis of safety assessment considering all available data and the concerns related to endocrine activity, the SCCS is of the opinion that the use of Butylparaben as a preservative in cosmetic products at concentrations of up to 0.14% (expressed as acid) is safe.(2) Alternatively, what is according to the SCCS the maximum concentration considered safe for use of Butylparaben as a preservative in cosmetic products?/(3) Does the SCCS have any further scientific concerns with regard to the use of Butylparaben in cosmetic products?In the absence of solid exposure data for children to Butylparaben in cosmetic products, potential safety concerns have been noted by the SCCS.The SCCS mandates do not address environmental aspects. Therefore, this assessment did not cover the safety of Butylparaben for the environment.Keywords:SCCS, scientific opinion, butylparaben, preservative, Regulation 1223/2009, CAS No. 94-26-8, EC No. 202-318-7Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on butylparaben (CAS No. 94-26-8, EC No. 202-318-7), preliminary version of 6-7 June 2023, SCCS/1651/23.
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- 2023
16. The SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and their Safety Evaluation- 12th Revision - SCCS/1647/22
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Benfentati, E., Cabaton, N., Corsini, E., Koutsodimou, A., Louro, H., Uter, W., Goetz, N. Von, Krätke, R., CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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SCCS ,SCCS/1647/22 ,12th revision ,SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and their Safety Evaluation ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] - Abstract
International audience; The SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and their Safety Evaluation- 12th Revision - SCCS/1647/22U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von Goetz, R. KrätkeThe SCCS adopted this guidance document by written procedure on 15 May 2023 (203 Pages)Mise en ligne : 16 May 2023https://health.ec.europa.eu/publications/sccs-notes-guidance-testing-cosmetic-ingredients-and-their-safety-evaluation-12th-revision_enDetailsPublication date : 16 May 2023Author : Scientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers (Rapporteur), Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCHEER member: R. KrätkeSCCS external experts: E. Benfenati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzContact: SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1647/22Adopted on: 15 May 2023Conclusion of the opinion:The NoG have been revised and updated with emphasis on the following:• Importance of systematic literature review• Updating of animal-free alternative methods: NAM (New Approach Methodology), changes introduced for acute inhalation, skin irritation testing, eye irritation testing with DAL (Defined Approach for eye irritation, Liquid), DASS (Defined Approaches for Skin Sensitisation), new in vitro methods for genotoxicity testing (3D skin Comet; in vitro micronucleus)• Importance of AOP (Adverse Outcome Pathway), DAs (Defined Approaches), IATA (Integrated Approaches to Testing and Assessment), NGRA (Next Generation Risk Assessment) with definition of BER (Bioactivity/Exposure Ratio), TTC (Threshold of Toxicological Concern), iTTC (internal TTC)• Updating of in silico prediction possibilities• Exposure data reviewed (models, parameters specific for inhalation, aggregate exposure)• Exposure of children to different cosmetic product categories according to age• Sun protection by sunscreen products: rationale behind exposure data• Human biomonitoring (HBM) and differences with SCCS approach for risk assessment• CMRs reporting requirements• Endocrine active substances, introduction of non-monotonic dose response, reporting requirements• Templates for PBTK (Physiologically Based ToxicoKinetics) model description and parameter verification and analysisKeywords: SCCS, SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and their Safety Evaluation, 12th revision, SCCS/1647/22Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and their Safety Evaluation 12th revision, 15 May 2023, SCCS/1647/22.
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- 2023
17. SCIENTIFIC ADVICE – children exposure on Methyl salicylate,(methyl 2-hydroxybenzoate) - SCCS/1654/23 - Preliminary version
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Benfentati, E., Cabaton, N., Corsini, E., Koutsodimou, A., Louro, H., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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SCCS ,methyl 2-hydroxybenzoate ,Regulation 1223/2009 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,children exposure ,scientific advice ,methyl salicylate - Abstract
International audience; SCIENTIFIC ADVICE – children exposure on Methyl salicylate,(methyl 2-hydroxybenzoate) - SCCS/1654/23 - Preliminary versionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzThe SCCS adopted this document by written procedure on 15 May 2023 (22 Pages)Mise en ligne : 16 May 2023https://health.ec.europa.eu/publications/sccs-scientific-advice-children-exposure-methyl-salicylate-methyl-2-hydroxybenzoate_enhttps://health.ec.europa.eu/system/files/2023-05/sccs_o_274.pdfDetailsPublication date : 16 May 2023Author : Scientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle (Rapporteur), M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: E. Benfenati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzContact: SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1654/23Adopted on: 16 May 2023Conclusion of the opinion:In the SCCS/1633/21 Opinion, the Committee concluded that Methyl Salicylate in toothpaste is safe for children under 6 years of age when used up to the maximum concentration of 2.52%.(1) In light of the data provided and taking under consideration the conclusions of SCCS/1633/21 and the aggregate exposure, does the SCCS consider Methyl Salicylate safe for children of age 0-3, when used up to a maximum concentration of 0.02% in all of the currently regulated cosmetic products included in Table 1 (except toothpaste in which up to 2.52% can be used)?In view of the conclusions of SCCS/1633/21 and the aggregate exposure, the SCCS considers the use of Methyl Salicylate as safe in cosmetic products intended for children of age 0.5-3 years when used up to a maximum concentration of 0.02% in shower gel, hand soap, shampoo, body lotion, face cream, hand cream, lip products. For toothpaste up to a maximum concentration of 2.52% methyl salicylate is considered safe.As no specific data were provided by the applicant for children below 6 months, the SCCS has not considered this age category in this safety assessment.(2) In light of the data provided and taking under consideration the conclusions of SCCS/1633/21 and the aggregate exposure, does the SCCS consider Methyl Salicylate safe for children of age 3-6, when used up to the allowed maximum concentrations for each of the currently regulated cosmetic products included in Table 1 (except toothpaste in which up to 2.52% can be used)?In Annex-1 of this Opinion, the SCCS has noted the basis for concerns over risks that the use of fullerenes, hydroxylated fullerenes and hydrated forms of hydroxylated fullerenes in cosmetic products may pose to the consumer. In brief, the SCCS has a concern in regard to:In view of the conclusions of SCCS/1633/21 and the aggregate exposure, the SCCS considers the use of Methyl Salicylate as safe in cosmetic products intended for children of age 3-6 years, when used up to a maximum concentration of 0.02% in shower gel, hand soap, shampoo, body lotion, face cream, hand cream, lip products, hair conditioner up to the allowed maximum concentrations indicated in Table 1. For toothpaste up to a maximum concentration of 2.52% methyl salicylate is considered safe.Keywords:SCCS, scientific advice, methyl salicylate, methyl 2-hydroxybenzoate, children exposure, Regulation 1223/2009Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Scientific Advice on methyl salicylate (methyl 2-hydroxybenzoate) – children exposure, preliminary version of 16 May 2023, SCCS/1654/23.
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- 2023
18. SCIENTIFIC ADVICE on HC Blue 18 (Colipa No. B122) - Submission II - SCCS/1653/23
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Bernauer, U., Bodin, L., Chaudhry, Q., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Benfentati, E., Cabaton, N., Corsini, E., Koutsodimou, A., Louro, H., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Scientific Committee for Consumer Safety (SCCS, EC)
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hair dye ,SCCS ,Colipa No B122 ,CAS No. 1166834-57-6 ,HC Blue 18 ,Submission II ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,scientific advice - Abstract
International audience; SCIENTIFIC ADVICE on HC Blue 18 (Colipa No. B122) - Submission II - SCCS/1653/23U. Bernauer, L. Bodin, Q. Chaudhry, .J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzThe SCCS adopted this document by written procedure on 27 April 2023 (24 Pages)Mise en ligne : 8 Mai 2023https://health.ec.europa.eu/publications/sccs-scientific-advice-hc-blue-18-colipa-no-b122-submission-ii_enDetailsPublication date 8 May 2023Author : Scientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli, E. Panteri (Rapporteur), V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von GoetzContact:SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1653/23Adopted on: 27 April 2023Conclusion of the opinion:1. In light of the data provided, does the SCCS consider HC Blue 18, safe when used in non-oxidative as well as in oxidative hair dye formulations up to a maximum on-head concentration of 0.35 %?In light of the new physicochemical data provided, SCCS considers that the use of HC Blue 18 as an ingredient in non-oxidative as well as in oxidative hair dye formulations up to a maximum on-head concentration of 0.35% is safe.2. Does the SCCS have any further scientific concerns with regard to the use of HC Blue 18 in cosmetic products?SCCS considers HC Blue 18 as a moderate sensitiser.Keywords:SCCS, scientific advice, hair dye, HC Blue 18, Colipa No B122, Submission II, CAS No. 1166834-57-6Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Scientific advice on HC Blue 18 (Colipa No. B122) – submission II, 27 April 2023, SCCS/1653/23.
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- 2023
19. Low Seroprevalence of HTLV-I and HTLV-II in Patients with a Sexually Transmitted Disease
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Suligoi, B., Galli, C., Ciuta, S., Decker, R., Albano, F., D'Antuono, A., Calabrò, G., Caprilli, F., Donofrio, P., Gaddoni, G., Gentili, G., Graifemberghi, S., Latino, M.A., Maiello, C., Manca, N., Mignani, E., Priano, L., Puiatti, P., Re, M.C., Rossetti, G., and Scardigli, F.
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- 1999
20. Oxidative Stress in Structural Valve Deterioration: A Longitudinal Clinical Study
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Galinanes, M, Casos, K, Blasco-Lucas, A, Permanyer, E, Manez, R, Le Tourneau, T, Barquinero, J, Schwartz, S, Roussel, T, Fellah-Hebia, I, Senage, T, Evangelista, A, Badano, L, Ruiz-Majoral, A, Galli, C, Padler-Karavani, V, Soulillou, J, Vidal, X, Cozzi, E, Costa, C, Galinanes M., Casos K., Blasco-Lucas A., Permanyer E., Manez R., Le Tourneau T., Barquinero J., Schwartz S., Roussel T. B. J. C., Fellah-Hebia I., Senage T., Evangelista A., Badano L., Ruiz-Majoral A., Galli C., Padler-Karavani V., Soulillou J. -P., Vidal X., Cozzi E., Costa C., Galinanes, M, Casos, K, Blasco-Lucas, A, Permanyer, E, Manez, R, Le Tourneau, T, Barquinero, J, Schwartz, S, Roussel, T, Fellah-Hebia, I, Senage, T, Evangelista, A, Badano, L, Ruiz-Majoral, A, Galli, C, Padler-Karavani, V, Soulillou, J, Vidal, X, Cozzi, E, Costa, C, Galinanes M., Casos K., Blasco-Lucas A., Permanyer E., Manez R., Le Tourneau T., Barquinero J., Schwartz S., Roussel T. B. J. C., Fellah-Hebia I., Senage T., Evangelista A., Badano L., Ruiz-Majoral A., Galli C., Padler-Karavani V., Soulillou J. -P., Vidal X., Cozzi E., and Costa C.
- Abstract
The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. Blood samples were taken from SVD (Phase A) and BHV patients during the first 24 (Phase B1) and >48 months (Phase B2) after BHV implantation to assess total antioxidant capacity (TAC), malondialdehyde (MDA), and nitrotyrosine (NT). The results show that MDA levels increased significantly 1 month after surgery in all groups but were higher at 6 months only in incipient SVD patients. NT levels increased gradually for the first 24 months after implantation in the BHV group. Patients with transcatheter aortic valve implantation (TAVI) showed even higher levels of stress markers. After >48 months, MDA and NT continued to increase in BHV patients with a further elevation after 60-72 months; however, these levels were significantly lower in the incipient and established SVD groups. In conclusion, oxidative stress may play a significant role in SVD, increasing early after BHV implantation, especially in TAVI cases, and also after 48 months' follow-up, but decreasing when SVD develops. Oxidative stress potentially represents a target of therapeutic intervention and a biomarker of BHV dysfunction.
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- 2022
21. Early molecular evolution tracking of emerging Enterovirus D68 by complete genome sequencing
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Giardina, F., primary, Pellegrinelli, L., additional, Ferrari, G., additional, Mariani, B. N., additional, Seiti, A., additional, Galli, C., additional, Pariani, E., additional, Piralla, A., additional, and Baldanti, F., additional
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- 2023
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22. Detection and molecular characterization of Human Parechovirus (HPeV) in respiratory infections in Lombardy (Northern Italy), from August 2022 to February 2023
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Seiti, A., primary, Pellegrinelli, L., additional, Galli, C., additional, Primache, V., additional, Anselmi, G., additional, Matteucci, E., additional, Binda, S., additional, and Pariani, E., additional
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- 2023
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23. Enhanced detection of overt HBV infection in chronic HCV carriers
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Mizzoni, K., primary, Meschi, S., additional, Garbuglia, A.R., additional, Galli, C., additional, and Maggi, F., additional
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- 2023
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24. Improved scaffold biocompatibility through anti-Fibronectin aptamer functionalization
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Galli, C., Parisi, L., Piergianni, M., Smerieri, A., Passeri, G., Guizzardi, S., Costa, F., Lumetti, S., Manfredi, E., and Macaluso, G.M.
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- 2016
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25. SCCS OPINION on Sodium Bromothymol Blue (C186) (CAS No. 34722-90-2, EC No. 252-169-7) - SCCS/1645/22 - Final Version
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Koutsodimou, A., Uter, W., Goetz, N. Von, Cabaton, Nicolas J., CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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hair dye ,SCCS ,C186 ,Regulation 1223/2009 ,CAS No. 34722-90-2 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,sodium bromothymol blue ,EC No. 252-169-7 ,scientific opinion - Abstract
International audience; SCCS OPINION on Sodium Bromothymol Blue (C186) (CAS No. 34722-90-2, EC No. 252-169-7) - SCCS/1645/22 - Final VersionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzThe SCCS adopted this document at its plenary meeting on 21 and 22 March 2023 (47pages)Mise en ligne 23 Mars 2023 https://health.ec.europa.eu/publications/sccs-sodium-bromothymol-blue-c186-cas-no-34722-90-2-ec-no-252-169-7_enhttps://health.ec.europa.eu/system/files/2023-03/sccs_o_267.pdfDetailsPublication date23 March 2023AuthorScientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam (Rapporteur), E. Gaffet, C.L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzContact:SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1645/22Adopted on: 21-22 March 2023Conclusion of the opinion:In light of the data provided, does the SCCS consider Sodium Bromothymol Blue safe when used in non-oxidative hair colouring products up to a maximum on-head concentration of 0.5 %?Having considered the data provided, the SCCS is of the opinion that the safety of sodium bromothymol blue cannot be assessed because of the following reasons:- The Applicant used TTC approach to justify the safety of sodium bromothymol blue, but the SCCS estimate of the SED indicates that it exceeds the TTC threshold for Cramer class III substances.- The use of TTC on its own to justify the safety of the substances that are regulated under the EU Cosmetic Regulation is not sufficient to waive the information requirements on essential toxicological endpoints.2. Does the SCCS have any further scientific concerns with regard to the use of Sodium Bromothymol Blue in cosmetic products?While the use of TTC is acceptable to justify the safety of impurities and cosmetic ingredients that are added to a final product at sufficiently low concentrations, it is not acceptable on its own for the substances that ar regulated under the EU Cosmetic Regulation. Additional supporting data from NAMs that are scientifically-accepted for the purpose, and/or other acceptable in vivo data on systemic toxicity, are also required in an overall weight of evidence to assess safety.Keywords:SCCS, scientific opinion, sodium bromothymol blue, C186, hair dye, Regulation 1223/2009, CAS No. 34722-90-2, EC No. 252-169-7Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on sodium bromothymol blue (C186) (CAS No. 34722-90-2, EC No. 252-169-7), preliminary version of 24-25 October 2022, final version of 21-22 March 2023, SCCS/1645/22
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- 2023
26. SCCS OPINION on the safety of aluminium in cosmetic products - Submission III - SCCS / 1644/22 – Final Opinion and Corrigendum
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Cabaton, N., Koutsodimou, A., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Commitee for Consumer Safety (SCCS, EC)
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SCCS ,revision ,Regulation 1223/2009 ,aluminium ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,scientific opinion ,submission III - Abstract
International audience; SCCS OPINION on the safety of aluminium in cosmetic products - Submission III - SCCS / 1644/22 – Final Opinion and CorrigendumU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzThe SCCS adopted this document at its plenary meeting on 21 and 22 March 2023 (62 Pages)Mise en ligne : 23 Mars 2023https://health.ec.europa.eu/publications/sccs-safety-aluminium-cosmetic-products-submission-iii_enhttps://health.ec.europa.eu/system/files/2023-03/sccs_o_266_0.pdfDetailsPublication date2 February 2023AuthorScientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: N. Cabaton, A. Koutsodimou, W. Uter, N. von Goetz (Rapporteur)Contact:SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1644/22Adopted on: 1 February 2023A corrigendum has been adopted on 21 March 2023 adding a note explaining that “AP” means “antiperspirant” under Table 6 of the Applicant.Conclusion of the opinion:1. In light of the new data provided, does the SCCS consider Aluminium compounds safe when used in cosmetic products other than deodorants, antiperspirants, lipsticks and toothpastes? In the event that the estimated exposure to Aluminium from cosmetic products is found to be of concern, SCCS is asked to recommend safe concentration limits for each category.The SCCS considers that aluminium compounds are safe when used-in non-sprayable product categories at the maximum levels indicated in Tables 4 and 6; and- in sprayable products, at the maximum levels indicated in Table 4, provided that the percentage of particles/droplets with a diameter of less than 10 μm does not exceed 20% of the total aerosolised particles/droplets. Since the Applicant’s data submission indicated that aluminium is not used in sunscreen aerosol sprays, this Opinion does not cover sunscreen aerosol sprays.2. Does the SCCS have any further scientific concerns regarding the use of relevant Aluminium compounds in cosmetic products taking into account the newly submitted information on aggregate exposure to Aluminium from cosmetics, medicines (e.g. antacids) and food intake?As aluminium does not belong to substances classified as CMR 1A or B, only exposure from cosmetic uses was considered in this safety assessment with the exposure assessment based on maximum use levels for cosmetic ingredients.However, the submission also provided a scenario where realistic exposure from non-cosmetic sources of aluminium (food and pharmaceuticals) was aggregated along with exposure from cosmetics at use levels from the year 2016. From this scenario, it can be deduced that contribution to aluminium exposure from food may be at a similar order of magnitude to that from cosmetics used for the safety assessment. Considering the conservative nature of the estimates, the aggregate exposure to aluminium from cosmetic and non-cosmetic sources may exceed safe limits for consumers at the highest exposure ranges.Keywords:SCCS, revision, scientific opinion, aluminium, submission III, Regulation 1223/2009Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on the safety of aluminium in cosmetic products - Submission III, preliminary version of 6 May 2022, final version of 1 February 2023, Corrigendum 21 March 2023, SCCS/1644/22
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- 2023
27. SCCS OPINION on the safety of aluminium in cosmetic products - Submission III - SCCS / 1644/22 – Final Opinion
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Eric GAFFET, Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P. J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Panteri, E., Rogiers, V., Ch. Rousselle, Stepnik, M., Vanhaecke, T., Wijnhoven, S., Cabaton, N., Koutsodimou, A., Uter, W., Goetz, N., Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Scientific Committee for Consumer Safety (SCCS) (SCCS), CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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SCCS ,revision ,Regulation 1223/2009 ,aluminium ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,scientific opinion ,submission III - Abstract
International audience; SCCS OPINION on the safety of aluminium in cosmetic products - Submission III - SCCS / 1644/22 – Final OpinionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzThe SCCS adopted this document by written procedure on 1st Februray 2023 (60 Pages)Mise en ligne : 2 February 2023https://health.ec.europa.eu/publications/sccs-safety-aluminium-cosmetic-products-submission-iii_enhttps://health.ec.europa.eu/system/files/2023-02/sccs_o_266.pdfDetailsPublication date 2 February 2023Author Scientific Committee on Consumer Safety (SCCS)Description SCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: N. Cabaton, A. Koutsodimou, W. Uter, N. von Goetz (Rapporteur)Contact:SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1644/22Adopted on: 1 February 2023Conclusion of the opinion:1. In light of the new data provided, does the SCCS consider Aluminium compounds safe when used in cosmetic products other than deodorants, antiperspirants, lipsticks and toothpastes? In the event that the estimated exposure to Aluminium from cosmetic products is found to be of concern, SCCS is asked to recommend safe concentration limits for each category.The SCCS considers that aluminium compounds are safe when used-in non-sprayable product categories at the maximum levels indicated in Tables 4 and 6; and- in sprayable products, at the maximum levels indicated in Table 4, provided that the percentage of particles/droplets with a diameter of less than 10 μm does not exceed 20% of the total aerosolised particles/droplets. Since the Applicant’s data submission indicated that aluminium is not used in sunscreen aerosol sprays, this Opinion does not cover sunscreen aerosol sprays.2. Does the SCCS have any further scientific concerns regarding the use of relevant Aluminium compounds in cosmetic products taking into account the newly submitted information on aggregate exposure to Aluminium from cosmetics, medicines (e.g. antacids) and food intake?As aluminium does not belong to substances classified as CMR 1A or B, only exposure from cosmetic uses was considered in this safety assessment with the exposure assessment based on maximum use levels for cosmetic ingredients.However, the submission also provided a scenario where realistic exposure from non-cosmetic sources of aluminium (food and pharmaceuticals) was aggregated along with exposure from cosmetics at use levels from the year 2016. From this scenario, it can be deduced that contribution to aluminium exposure from food may be at a similar order of magnitude to that from cosmetics used for the safety assessment. Considering the conservative nature of the estimates, the aggregate exposure to aluminium from cosmetic and non-cosmetic sources may exceed safe limits for consumers at the highest exposure ranges.Keywords:SCCS, revision, scientific opinion, aluminium, submission III, Regulation 1223/2009Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on the safety of aluminium in cosmetic products - Submission III, preliminary version of 6 May 2022, final version of 1 February 2023, SCCS/1644/22
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- 2023
28. Bortezomib, C1-Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi-Transgenic GalT-KO Pig Kidney Xenografts in Baboons
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Le Bas-Bernardet, S., Tillou, X., Branchereau, J., Dilek, N., Poirier, N., Châtelais, M., Charreau, B., Minault, D., Hervouet, J., Renaudin, K., Crossan, C., Scobie, L., Takeuchi, Y., Diswall, M., Breimer, M.E., Klar, N., Daha, M.R., Simioni, P., Robson, S.C., Nottle, M.B., Salvaris, E.J., Cowan, P.J., d’Apice, A.J.F., Sachs, D.H., Yamada, K., Lagutina, I., Duchi, R., Perota, A., Lazzari, G., Galli, C., Cozzi, E., Soulillou, J.-P., Vanhove, B., and Blancho, G.
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- 2015
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29. ICHOSA (Intra Cerebral Hemorrage and Obstructive Sleep Apnea) project: first results
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Picchetto, L., primary, Pizza, F., additional, Bigliardi, G., additional, Giacobazzi, L., additional, Dell'Acqua, M., additional, Vandelli, L., additional, Ciolli, L., additional, Vandelli, G., additional, Rosafio, F., additional, Ricceri, R., additional, Galli, C., additional, Vitetta, F., additional, Zini, A., additional, Meletti, S., additional, and Plazzi, G., additional
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- 2022
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30. Outdoor artificial light at night and risk of early-onset dementia: A case-control study in the Modena population, Northern Italy
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Mazzoleni, E., Vinceti, M., Costanzini, S., Garuti, C., Adani, G., Vinceti, G., Zamboni, G., Tondelli, M., Galli, C., Salemme, S., Teggi, S., Chiari, A., and Filippini, T.
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- 2023
31. Blood fatty acid composition in relation to allergy in children aged 2-9 years: results from the European IDEFICS study
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Mikkelsen, A, Galli, C, Eiben, G, Ahrens, W, Iacoviello, L, Molnár, D, Pala, V, Rise, P., Rodriguez, G., Russo, P., Tornaritis, M., Veidebaum, T., Vyncke, K., and Wolters, M.
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Allergy in children -- Physiological aspects ,Blood -- Physiological aspects ,Fatty acids -- Physiological aspects ,Food/cooking/nutrition ,Health - Abstract
Background/objectives: Blood polyunsaturated fatty acids (PUFA) are involved in allergy development, but the etiological role of n-6 and n-3 PUFA is still controversial. A European multicenter study of children (IDEFICS) provided the opportunity to explore the cross-sectional association between fatty acids (FA) and allergy. Subjects/methods: Blood FA levels were measured in 2600 children aged 2-9 years and were recorded as the percentage of weight of all FA detected. Logistic regression of allergy status on FA components was adjusted for age, sex, country, body mass index, family history of allergic disease, breast-feeding, and number of siblings. The results were given as odds ratios (OR) for current vs no allergy ever and an increase in FA by 1 s.d. Results: Overall, higher proportions of n-6 PUFA were associated with higher odds of allergy (OR=1.21 (1.05, 1.40)). Monounsaturated FA (MUFA) were associated with reduced risk for allergy (OR=0.75 (0.65, 0.87)), whereas saturated FA did not differ by allergy status. The strongest associations were observed in children Conclusions: Both PUFA subtypes were positively associated with allergy in an age-dependent manner, whereas MUFA was associated with less allergy. The observation of high proportions of n-3 PUFA in allergic children younger than 4 years might help to understand the nature of early onset of atopic disease., Author(s): A Mikkelsen [sup.1] [sup.2] , C Galli [sup.3] , G Eiben [sup.1] , W Ahrens [sup.4] , L Iacoviello [sup.5] , D Molnár [sup.6] , V Pala [sup.7] , [...]
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- 2017
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32. Anti-fibronectin aptamers improve the colonization of chitosan films modified with D-(+) Raffinose by murine osteoblastic cells
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Parisi, L., Galli, C., Bianchera, A., Lagonegro, P., Elviri, L., Smerieri, A., Lumetti, S., Manfredi, E., Bettini, R., and Macaluso, G. M.
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- 2017
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33. SCCS OPINION on Genistein and Daidzein - SCCS/1641/22 Final version
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraad, P. J., Dusinska, M., Ezendam, J., Eric GAFFET, Galli, C. L., Granum, B., Panteri, E., Rogiers, V., Ch. Rousselle, Stepnik, M., Vanhaecke, T., Wijnhoven, S., Cabaton, N., Koutsodimou, A., Uter, W., Goetz, N., Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Direction des affaires européennes et internationales (DAEI), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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SCCS ,EC No 207-174-9) ,Regulation 1223/2009 ,daidzein (CAS No 486-66-8 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,EC No 207-635-4) ,scientific opinion ,genistein (CAS No 446-72-0 - Abstract
International audience; SCCS OPINION on Genistein and Daidzein - SCCS/1641/22 Final versionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraad, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzThe SCCS adopted this document by written procedure on 16 September 2022 (153 pages)Mise en ligne 23 Septembre 2022https://health.ec.europa.eu/publications/genistein-and-daidzein_enDetailsPublication date : 23 September 2022Author : Scientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer (Rapporteur Daidzein), L. Bodin, Q. Chaudhry (Rapporteur Genistein), P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli (Rapporteur Genistein), B. Granum (former member), E. Panteri, V. Rogiers, Ch. Rousselle (Rapporteur Daidzein), M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzContact:SANTE-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1641/22Adopted on: 16 September 2022Conclusion of the opinion: (1) In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of phytoestrogens,(a) does the SCCS consider genistein safe when used in cosmetic products up to a maximum concentration of 0.007%?(b) does the SCCS consider daidzein safe when used in cosmetic products up to a maximum concentration of 0.02%?From the safety assessment based on the available relevant data on the aglycone form of genistein and daidzein, and in consideration of the potential endocrine disrupting properties of phytoestrogens, the SCCS considers that:a) the use of genistein (CAS No 446-72-0, EC No 207-174-9) in cosmetic products up to a maximum concentration of 0.007% is safe.b) the use of daidzein (CAS No 486-66-8, EC No 207-635-4) in cosmetic products up to a maximum concentration of 0.02% is safe. (2) Alternatively, according to the SCCS what is the maximum concentration of genistein and daidzein that is considered safe for individual and combined use in cosmetic products?/(3) Does the SCCS have any further scientific concerns with regard to the use of genistein and daidzein or other related phytoestrogens in cosmetic products?/Keywords:SCCS, scientific opinion, genistein (CAS No 446-72-0, EC No 207-174-9), daidzein (CAS No 486-66-8, EC No 207-635-4), Regulation 1223/2009Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Scientific opinion on genistein and daidzein, preliminary version of 12 January 2022, final version of 16 September 2022, SCCS/1641/22.
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- 2022
34. SCCS OPINION ON the safety of presence of Bisphenol A in clothing articles - SCCS/16/2020 - Final Opinion
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Granum, B., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Koutsodimou, A., Uter, W., Goetz, N. Von, Comissariat à l'énergie atomique (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Publications Office of the European Union
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[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] - Abstract
International audience; To review the available data on the presence and activity of Bisphenol A in clothing articles, taking into consideration the adopted opinions on tolerable intake limits and the legislative framework in other products (food contact materials, toys and printed paper) Regarding potential health effects of BPA, this Opinion is based on the information present in the most recent health risk assessments conducted by EFSA (2015) and ECHA (2015). SCCS is, however, aware of the fact that EFSA is currently re-evaluating the huge amount of data on BPA toxicity that came available since December 2012, i.e. the cut-off point for their latest assessment published in 2015. Hence, all outcomes and conclusions reported in this document with respect to human health might be subject of change in the near future. If this is the case, the Opinion should be updated accordingly. Exposure to BPA may occur from various sources, both dietary and non-dietary. In this Opinion, the assessment is based only on one source of BPA (i.e. textiles) and does not take into account the contribution of other sources, nor does it apply to BPA analogues. Only one study provides experimental migration rates of BPA from clothing into artificial sweat (Wang et al. 2019). Based on these reported migration rates, migration fractions were calculated under conservative assumptions, with a 2-hour chronic daily contact of the whole trunk to clothes fully soaked in sweat for men and women. As for children, exposure to sweaty clothes was considered with additional oral exposure due to sucking on clothes. From these calculations, it can be estimated that for adults the internal total BPA exposure due to clothing is between 1.56 - 9.90 ng/kg bw/d. For toddlers, exposure to total BPA via clothing is higher i.e. between 2.37 – 14.8 ng/kg bw/d. Compared to the dietary exposure previously assessed by EFSA (2015), the exposure to BPA through clothing is at least 25 times lower. Due to the many upper bound scenario decisions made in the exposure assessment, this difference may be much larger in reality. Moreover, taking into account that Wang et al. (2019) is the only study as yet available for BPA migration rates from clothes and that very large migration fractions have been determined, it has to be confirmed that migration of BPA from clothes is really that high. In future studies, reproducibility of the migration experiment should be investigated, and time-dependent and fabric-specific migration rates derived.
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- 2022
35. ADDENDUM to the scientific opinion SCCS/1613/19 on the safety of aluminium in cosmetic products (lipstick) - Submission II - SCCS/1626/20 - Addendum (lipstick) – Final version
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Granum, B., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Koutsodimou, A., Uter, W., Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Scientific Committee for Consumer Safety (SCCS), and Publications Office of the European Union
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[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] - Abstract
International audience; The SCCS concludes the following: 1. In light of the new data provided, does the SCCS consider Aluminium safe when used in lipsticks up to a maximum concentration of 14%? In the event that the estimated exposure to Aluminium from lipsticks of cosmetic products is found to be of concern, SCCS is asked to recommend safe concentration limits. In the light of the new data provided, the SCCS considers that the use of aluminium compounds is safe at the following equivalent aluminium concentrations up to: · 6.25% in non-spray deodorants or non-spray antiperspirants · 10.60% in spray deodorants or spray antiperspirants · 2.65% in toothpaste and · 14% in lipstick 2. Does the SCCS have any further scientific concerns regarding the use of Aluminium substances in cosmetic products taking into account the newly submitted information on aggregate exposure from cosmetics? The SCCS considers that the systemic exposure to aluminium via daily applications of cosmetic products does not add significantly to the systemic body burden of aluminium from other sources. Exposure to aluminium may also occur from sources other than cosmetic products, and a major source of aluminium in the population is the diet. This assessment has not taken into account the daily dietary intake of aluminium.
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- 2022
36. SCCS OPINION on Methyl salicylate (methyl 2-hydroxybenzoate) - Submission I- SCCS/1633/21- Final Opinion
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraad, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Granum, B., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Koutsodimou, A., Uter, W., Goetz, N. Von, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Publications Office of the European Union
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[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] - Abstract
International audience; The SCCS concludes the following: 1. In light of the data provided and taking under consideration the RAC Opinion on Methyl salicylate and the expected new classification as Toxic for Reproduction Category 2 of Methyl salicylate (to be introduced by an update of Annex VI Reg. 1272/2008), does the SCCS consider Methyl salicylate safe when used up to the maximum concentrations provided in the dossier submitted by the applicant? The SCCS considers Methyl salicylate safe when used in cosmetic products up to the maximum concentrations provided in the dossier submitted by the applicant as detailed in Table 1. 2. Does the SCCS have any further scientific concerns with regard to the use of Methyl salicylate in cosmetic products, also in relation to the RAC recommended classification of Methyl salicylate as ‘Skin sensitizer Category 1B’? Methyl salicylate should be considered as a weak skin sensitiser in humans and eye irritant. Moreover the SCCS would like also to express other concerns related to the use of methyl salicylate: -Methyl salicylate can be used in consumer products other than cosmetic products, such as household cleaning products, air care products, biocides (e.g. disinfectants, pest control products), polishes and waxes which may increase the systemic exposure dose with a possibility to exceed the safe level. - Methyl salicylate will be metabolised in the body to salicylic acid which is also classified as a reprotoxicant and used in cosmetic products (see opinion SCCS/1601/18). Therefore the combined exposure to cosmetic products containing various salicylates may increase the systemic exposure dose with a possibility to exceed the safe level. The SCCS also notices that wintergreen oil that is used in cosmetic products may contain up to 99% methyl salicylate. Therefore when calculating the content of methyl salicylate in a cosmetic product, any fraction coming from wintergreen oil should also be considered.
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- 2022
37. Alternative pre-analytical strategies for SARS CoV 2 RNA detection
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Martinelli, M, Molteni, C, Calcagno, G, Bubba, L, Galli, C, Musumeci, R, Giubbi, C, Perdoni, F, Castriciano, S, Pariani, E, Pellegrinelli, L, Pilla, L, Bonfanti, P, Malandrin, S, Cavallero, A, Cocuzza, C, MARTINELLI, M, MOLTENI, C, CALCAGNO, G, BUBBA, L, GALLI, C, MUSUMECI, R, GIUBBI, C, PERDONI, F, CASTRICIANO, S, PARIANI, E, PELLEGRINELLI, L, PILLA, L, BONFANTI, P, MALANDRIN, S, CAVALLERO, A, COCUZZA, CE, Martinelli, M, Molteni, C, Calcagno, G, Bubba, L, Galli, C, Musumeci, R, Giubbi, C, Perdoni, F, Castriciano, S, Pariani, E, Pellegrinelli, L, Pilla, L, Bonfanti, P, Malandrin, S, Cavallero, A, Cocuzza, C, MARTINELLI, M, MOLTENI, C, CALCAGNO, G, BUBBA, L, GALLI, C, MUSUMECI, R, GIUBBI, C, PERDONI, F, CASTRICIANO, S, PARIANI, E, PELLEGRINELLI, L, PILLA, L, BONFANTI, P, MALANDRIN, S, CAVALLERO, A, and COCUZZA, CE
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- 2021
38. Whole-blood fatty acids and inflammation in European children: the IDEFICS Study
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Gonzalez-Gil, E.M., Santabarbara, J., Siani, A., Ahrens, W., Sioen, I., Eiben, G., Gunther, K., Iacoviello, L., Molnar, D., Rise, P., Russo, P., Tornaritis, M., Veidebaum, T., Galli, C., and Moreno, L.A.
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Inflammation -- Physiological aspects ,Fatty acids -- Health aspects ,Children -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
BACKGROUND/OBJECTIVES: Fatty acids are hypothesized to influence cardiovascular disease risk because of their effect on inflammation. The aim of this study is to assess the relationship between whole-blood fatty acids (WBFAs) and high- sensitivity C-reactive protein (hs-CRP) in European children. SUBJECTS/METHODS: A total of 1401 subjects (697 boys and 704 girls) aged between 2 and 9 years from the IDEFICS (/dentification and prevention of Dietary- and lifestyle-induced health Effects in Children and infantS) study were measured in this cross-sectional analysis. The sample was divided into three categories of hs-CRP. Associations between WBFA and hs-CRP were assessed by logistic regression models adjusting for body mass index (BMI), country, age, breastfeeding, mother's education and hours of physical activity. RESULTS: Linoleic acid (LA) (P = 0.013, 95% confidence interval (CI): 0.822-0.977) and sum of n-6 WBFA (P=0.029,95% CI: 0.866-0.992) concentrations were associated with lower concentrations of hs-CRP in boys. In girls, a high ratio of eicosapentaenoic acid (EPA)/arachidonic acid (AA) was associated (P=0.018, 95% CI: 0.892-0.989) with lower hs-CRP concentrations. In contrast, sum of blood n-6 highly unsaturated fatty acids (P = 0.012, 95% CI: 1.031-1.284), AA (P=0.007, 95% CI: 1.053-1.395) and AA/LA ratio (P = 0.005, 95% CI: 1.102-1.703) were associated (P < 0.05) with higher concentrations of hs-CRP in girls. CONCLUSIONS: The n-6 WBFAs (sum of n-6 FA and LA) were associated with lower hs-CRP in boys and with higher hs-CRP in girls (AA, sum of n-6 highly unsaturated and AA/LA ratio). More studies are needed to identify the optimal levels of WBFAs to avoid low-grade inflammation in children considering the differences by sex and BMI. European Journal of Clinical Nutrition (2016) 70, 819-823; doi: 10.1038/ejcn.2015.219; published online 13 January 2016, INTRODUCTION Low-grade chronic inflammation is related with obesity (1-3) and with the onset and development of atherosclerosis. (1,4) Athero-sclerosis development is characterized by an interaction between vascular endothelial cells and [...]
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- 2016
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39. SCCS OPINION on the safety of aluminium in cosmetic products - Submission III - SCCS / 1644/22 – Preliminary Opinion
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Granum, B., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Cabaton, N., Koutsodimou, A., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Scientific Committee for Consumer Safety (SCCS, EC), and Gaffet, Eric
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SCCS ,revision ,Regulation 1223/2009 ,aluminium ,MESH: SCCS, revision, scientific opinion, aluminium, submission III, Regulation 1223/2009 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,[PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,scientific opinion ,submission III - Abstract
International audience; SCCS OPINION on the safety of aluminium in cosmetic products - Submission III - SCCS / 1644/22 – Preliminary OpinionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzThe SCCS adopted this document by written procedure on 6 May 2022 (51 Pages)Mise en ligne 30 Mai 2022https://ec.europa.eu/health/publications/sccs-safety-aluminium-cosmetic-products-submission-iii_enDescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: N. Cabaton, A. Koutsodimou, W. Uter, N. von Goetz (Rapporteur)Contact:SANTE-C2-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1644/22Adopted on: 6 May 2022Conclusion of the opinion:1. In light of the new data provided, does the SCCS consider Aluminium compounds safe when used in cosmetic products other than deodorants, antiperspirants, lipsticks and toothpastes? In the event that the estimated exposure to Aluminium from cosmetic products is found to be of concern, SCCS is asked to recommend safe concentration limits for each category.The SCCS considers that aluminium compounds are safe when useda. in non-sprayable product categories at the maximum levels indicated in Table 4;andb. in sprayable antiperspirant products, provided that the maximum percentage of particles with 10 μm diameter does not exceed 20% of the total aerosolised particlesThe SCCS could not assess safety of aluminium compounds in sprayable applications other than antiperspirant. These applications (including eau de toilette, eau de parfum and hair spray) are therefore excluded from this Opinion.2. Does the SCCS have any further scientific concerns regarding the use of relevant Aluminium compounds in cosmetic products taking into account the newly submitted information on aggregate exposure to Aluminium from cosmetics, medicines (e.g. antacids) and food intake?As aluminium does not belong to substances classified as CMR 1A and B, only exposure from cosmetic uses was considered in this safety assessment.However, in a scenario provided by the Applicant, where exposure from non-cosmetic sources of aluminium (food and pharmaceuticals) was aggregated with exposure from cosmetics, food contributed in a similar order of magnitude as cosmetics. The aggregate exposure to aluminum from cosmetic and non-cosmetic sources may therefore exceed safe limits.Keywords:SCCS, revision, scientific opinion, aluminium, submission III, Regulation 1223/2009Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on the safety of aluminium in cosmetic products - Submission III, preliminary version of 6 May 2022, SCCS/1644/22
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- 2022
40. SCCS OPINION on 4-Methylbenzylidene camphor (4-MBC) - SCCS/1640/21 - Final version
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraad, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Granum, B., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Cabaton, N., Koutsodimou, A., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Scientific Committee for Consumer Safety (SCCS, EC), and Gaffet, Eric
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SCCS ,revision ,CAS No 36861-47-9/38102-62-4 ,EC No 253-242-6 ,Regulation 1223/2009 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,[PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,scientific opinion ,4-Methylbenzylidene camphor (4-MBC) - Abstract
International audience; Publication date10 May 2022Author : Scientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam (Rapporteur), E. Gaffet, C.L. Galli, B. Granum, E. Panteri (Rapporteur), V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzContact:SANTE-C2-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1640/21Adopted on: 29 April 2022Conclusion of the opinion:(1) In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of 4-Methylbenzylidene camphor (4-MBC), does the SCCS consider 4-MBC safe when used as a UV-filter in cosmetic products up to a maximum concentration of 4%?The SCCS cannot conclude on the safety of 4-MBC, because the information provided is insufficient to fully evaluate potential genotoxicity.Moreover, there is sufficient evidence that 4-MBC may act as an endocrine disruptor and has effects on both the thyroid and estrogen systems. Effects on the androgen system are not so evident, as only in vitro evidence is available.Even if the genotoxic potential was excluded, the current re-evaluation of 4-MBC established a higher exposure level than in the previous Opinion. This would result in a lower MoS value, indicating that the use of 4-MBC at the maximum concentration of 4% in cosmetic ingredients would not be safe.(2) Alternatively, what is according to the SCCS the maximum concentration considered safe for use of 4-MBC as a UV-filter in cosmetic products?It is not possible to derive a maximum concentration for safe use of 4-MBC, because a genotoxicity potential cannot be excluded.(3) Does the SCCS have any further scientific concerns with regard to the use of 4-MBC in cosmetic products?The SCCS mandate does not address environmental aspects. Therefore, this assessment did not cover the safety of 4-MBC for the environment.Keywords:SCCS, revision, scientific opinion, 4-Methylbenzylidene camphor (4-MBC), CAS No 36861-47-9/38102-62-4, EC No 253-242-6, Regulation 1223/2009Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), scientific opinion on 4-Methylbenzylidene camphor (4-MBC), preliminary version of 22 December, final version of 29 April 2022, SCCS/1640/21.
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- 2022
41. Being the Family Caregiver of a Patient With Dementia During the Coronavirus Disease 2019 Lockdown
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Zucca, M., Isella, V., Lorenzo, R. D., Marra, Camillo, Cagnin, A., Cupidi, C., Bonanni, L., Lagana, V., Rubino, E., Vanacore, N., Agosta, F., Caffarra, P., Sambati, R., Quaranta, Davide, Guglielmi, Valeria, Appollonio, I. M., Logroscino, G., Filippi, M., Tedeschi, G., Ferrarese, C., Rainero, I., Bruni, A. C., Gallo, E., Grassini, A., Marcinno, A., Roveta, F., Martino, P. D., Frangipane, F., Puccio, G., Colao, R., Mirabelli, M., Martellacci, N., Lino, F., Mozzetta, S., Busse, C., Camporese, G., Sacco, S., Lechiara, M. C., Carrarini, Claudia, Russo, M., Casalena, A., Sucapane, P., Tiraboschi, P., Caroppo, P., Redaelli, V., Fede, G. D., Coppa, D., Peluso, L., Insarda, P., Bartolo, M. D., Esposito, S., Iavarone, A., Orsini, A. V. M., Salvatore, E., Criscuolo, C., Sambati, L., Santoro, R., Gragnaniello, D., Pedriali, I., Ludovico, L., Chiari, A., Fabbo, A., Bevilacqua, P., Galli, C., Magarelli, S., Perini, M., Spalletta, G., Banaj, N., Porcari, D. E., Caruso, G., Cipollini, V., Casini, A. R., Ursini, F., Bruno, G., Rozzini, R., Brambilla, M., Magnani, G., Caso, F., Spinelli, E. G., Ramusino, M. C., Perini, G., Luzzi, S., Cacchio, G., Ciccola, A., Cionfrini, L., Giuli, C., Fabi, K., Guidi, M., Paci, C., Castellano, A., Petrucci, R., Accogli, M., Carapelle, E., Calabrese, G., Trevisi, G. N., Coluccia, B., Giuliano, A. V., Caggiula, M., Impagnatiello, V., Beretta, F., Milia, A., Pilia, G., Mascia, M. G., Putzu, V., Piccoli, T., Cuffaro, L., Monastero, R., Battaglia, A., Blandino, V., Lupo, F., Cumbo, E., Luca, A., Caravaglios, G., Vezzosi, A., Bessi, V., Tognoni, G., Calsolaro, V., Mossello, E., Amici, S., Trequattrini, A., Pezzuto, S., Mecocci, P., Fichera, G., Pradelli, S., Formilan, M., Coin, A., Togni, L. D., Sala, F., Nicolosi, V., Gallucci, M., Mazzarolo, A. P., Bergamelli, C., Zucca M., Isella V., Lorenzo R.D., Marra C., Cagnin A., Cupidi C., Bonanni L., Lagana V., Rubino E., Vanacore N., Agosta F., Caffarra P., Sambati R., Quaranta D., Guglielmi V., Appollonio I.M., Logroscino G., Filippi M., Tedeschi G., Ferrarese C., Rainero I., Bruni A.C., Gallo E., Grassini A., Marcinno A., Roveta F., Martino P.D., Frangipane F., Puccio G., Colao R., Mirabelli M., Martellacci N., Lino F., Mozzetta S., Busse C., Camporese G., Sacco S., Lechiara M.C., Carrarini C., Russo M., Casalena A., Sucapane P., Tiraboschi P., Caroppo P., Redaelli V., Fede G.D., Coppa D., Peluso L., Insarda P., Bartolo M.D., Esposito S., Iavarone A., Orsini A.V.M., Salvatore E., Criscuolo C., Sambati L., Santoro R., Gragnaniello D., Pedriali I., Ludovico L., Chiari A., Fabbo A., Bevilacqua P., Galli C., Magarelli S., Perini M., Spalletta G., Banaj N., Porcari D.E., Caruso G., Cipollini V., Casini A.R., Ursini F., Bruno G., Rozzini R., Brambilla M., Magnani G., Caso F., Spinelli E.G., Ramusino M.C., Perini G., Luzzi S., Cacchio G., Ciccola A., Cionfrini L., Giuli C., Fabi K., Guidi M., Paci C., Castellano A., Petrucci R., Accogli M., Carapelle E., Calabrese G., Trevisi G.N., Coluccia B., Giuliano A.V., Caggiula M., Impagnatiello V., Beretta F., Milia A., Pilia G., Mascia M.G., Putzu V., Piccoli T., Cuffaro L., Monastero R., Battaglia A., Blandino V., Lupo F., Cumbo E., Luca A., Caravaglios G., Vezzosi A., Bessi V., Tognoni G., Calsolaro V., Mossello E., Amici S., Trequattrini A., Pezzuto S., Mecocci P., Fichera G., Pradelli S., Formilan M., Coin A., Togni L.D., Sala F., Nicolosi V., Gallucci M., Mazzarolo A.P., Bergamelli C., Zucca, M, Isella, V, Di Lorenzo, R, Marra, C, Cagnin, A, Cupidi, C, Bonanni, L, Laganà, V, Rubino, E, Vanacore, N, Agosta, F, Caffarra, P, Sambati, R, Quaranta, D, Guglielmi, V, Appollonio, I, Logroscino, G, Filippi, M, Tedeschi, G, Ferrarese, C, Rainero, I, Bruni, A, Gallo, E, Grassini, A, Marcinnò, A, Roveta, F, De Martino, P, Frangipane, F, Puccio, G, Colao, R, Mirabelli, M, Martellacci, N, Lino, F, Mozzetta, S, Bussè, C, Camporese, G, Sacco, S, Lechiara, M, Carrarini, C, Russo, M, Casalena, A, Sucapane, P, Tiraboschi, P, Caroppo, P, Redaelli, V, Di Fede, G, Coppa, D, Peluso, L, Insarda, P, De Bartolo, M, Esposito, S, Iavarone, A, Orsini, A, Salvatore, E, Criscuolo, C, Sambati, L, Santoro, R, Gragnaniello, D, Pedriali, I, Ludovico, L, Chiari, A, Fabbo, A, Bevilacqua, P, Galli, C, Magarelli, S, Perini, M, Spalletta, G, Banaj, N, Porcari, D, Caruso, G, Cipollini, V, Casini, A, Ursini, F, Bruno, G, Rozzini, R, Brambilla, M, Magnani, G, Caso, F, Spinelli, E, Cotta Ramusino, M, Perini, G, Luzzi, S, Cacchiò, G, Ciccola, A, Cionfrini, L, Giuli, C, Fabi, K, Guidi, M, Paci, C, Castellano, A, Petrucci, R, Accogli, M, Carapelle, E, Calabrese, G, Trevisi, G, Coluccia, B, Vasquez Giuliano, A, Caggiula, M, Impagnatiello, V, Beretta, F, Milia, A, Pilia, G, Mascia, M, Putzu, V, Piccoli, T, Cuffaro, L, Monastero, R, Battaglia, A, Blandino, V, Lupo, F, Cumbo, E, Luca, A, Caravaglios, G, Vezzosi, A, Bessi, V, Tognoni, G, Calsolaro, V, Mossello, E, Amici, S, Trequattrini, A, Pezzuto, S, Mecocci, P, Fichera, G, Pradelli, S, Formilan, M, Coin, A, De Togni, L, Sala, F, Nicolosi, V, Gallucci, M, Mazzarolo, A, Bergamelli, C, Zucca, Milena, Isella, Valeria, Lorenzo, Raffaele Di, Marra, Camillo, Cagnin, Annachiara, Cupidi, Chiara, Bonanni, Laura, Laganà, Valentina, Rubino, Elisa, Vanacore, Nicola, Agosta, Federica, Caffarra, Paolo, Sambati, Renato, Quaranta, Davide, Guglielmi, Valeria, Appollonio, Ildebrando M., Logroscino, Giancarlo, Filippi, Massimo, Tedeschi, Gioacchino, Ferrarese, Carlo, Rainero, Innocenzo, and Bruni, Amalia C.
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Aging ,medicine.medical_specialty ,Cognitive Neuroscience ,Population ,Psychological intervention ,Protective factor ,Neurosciences. Biological psychiatry. Neuropsychiatry ,burden ,03 medical and health sciences ,stress ,0302 clinical medicine ,stre ,medicine ,Dementia ,caregiver ,COVID-19 ,dementia ,Psychiatry ,education ,Original Research ,MED/26 - NEUROLOGIA ,education.field_of_study ,030214 geriatrics ,burden, caregiver, COVID-19, dementia, stress ,Family caregivers ,business.industry ,medicine.disease ,Mental health ,Settore MED/26 - NEUROLOGIA ,Anxiety ,Caregiver stress ,M-PSI/08 - PSICOLOGIA CLINICA ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Neuroscience ,RC321-571 - Abstract
Background: Family caregivers of patients with dementia are at high risk of stress and burden, and quarantine due to the coronavirus disease 2019 (COVID-19) pandemic may have increased the risk of psychological disturbances in this population. The current study was carried out during the national lockdown declared in March 2020 by the Italian government as a containment measure of the first wave of the coronavirus pandemic and is the first nationwide survey on the impact of COVID-19 lockdown on the mental health of dementia informal caregivers.Methods: Eighty-seven dementia centers evenly distributed on the Italian territory enrolled 4,710 caregiver–patient pairs. Caregivers underwent a telephone interview assessing classical symptoms of caregiver stress and concern for the consequences of COVID-19 infection on patient’s health. We calculated prevalence of symptoms and regressed them on various potential stress risk factors: caregivers’ sociodemographic characteristics and lifestyle, patients’ clinical features, and lockdown-related elements, like discontinuity in medical care.Results: Approximately 90% of caregivers reported at least one symptom of stress, and nearly 30% reported four or more symptoms. The most prevalent symptoms were concern for consequences of COVID-19 on patient’s health (75%) and anxiety (46%). The main risk factors for stress were identified as a conflicting relationship with the patient and discontinuity in assistance, but caregiver’s female sex, younger age, lower education, and cohabitation with the patient also had an impact. Availability of help from institutions or private individuals showed a protective effect against sense of abandonment but a detrimental effect on concern about the risk for the patient to contract COVID-19. The only protective factor was mild dementia severity, which was associated with a lower risk of feeling isolated and abandoned; type of dementia, on the other hand, did not affect stress risk.Conclusion: Our results demonstrate the large prevalence of stress in family caregivers of patients with dementia during the COVID-19 pandemic and have identified both caregivers and situations at a higher risk of stress, which should be taken into account in the planning of interventions in support of quarantined families and patients.
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- 2021
42. SARS-CoV-2 infection among asymptomatic homebound subjects in Milan, Italy
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Milani, G, Montomoli, E, Bollati, V, Albetti, B, Bandi, C, Bellini, T, Bonzini, M, Buscaglia, M, Cantarella, C, Cantone, L, Carugno, M, Casartelli, S, Cavaletti, G, D'Alessandro, S, De Chiara, F, Delbue, S, Dioni, L, Eberini, I, Favero, C, Ferrari, L, Ferraroni, M, Galastri, L, Galli, C, Hoxha, M, Iodice, S, La Vecchia, C, Macchi, C, Manini, I, Marchi, S, Mariani, J, Pariani, E, Pesatori, A, Rota, F, Ruscica, M, Schioppo, T, Tarantini, L, Trombetta, C, Valsecchi, M, Vicenzi, M, Zanchetta, G, Milani G. P., Montomoli E., Bollati V., Albetti B., Bandi C., Bellini T., Bonzini M., Buscaglia M., Cantarella C., Cantone L., Carugno M., Casartelli S., Cavaletti G., D'Alessandro S., De Chiara F., Delbue S., Dioni L., Eberini I., Favero C., Ferrari L., Ferraroni M., Galastri L., Galli C., Hoxha M., Iodice S., La Vecchia C., Macchi C., Manini I., Marchi S., Mariani J., Pariani E., Pesatori A. C., Rota F., Ruscica M., Schioppo T., Tarantini L., Trombetta C. M., Valsecchi M. G., Vicenzi M., Zanchetta G., Milani, G, Montomoli, E, Bollati, V, Albetti, B, Bandi, C, Bellini, T, Bonzini, M, Buscaglia, M, Cantarella, C, Cantone, L, Carugno, M, Casartelli, S, Cavaletti, G, D'Alessandro, S, De Chiara, F, Delbue, S, Dioni, L, Eberini, I, Favero, C, Ferrari, L, Ferraroni, M, Galastri, L, Galli, C, Hoxha, M, Iodice, S, La Vecchia, C, Macchi, C, Manini, I, Marchi, S, Mariani, J, Pariani, E, Pesatori, A, Rota, F, Ruscica, M, Schioppo, T, Tarantini, L, Trombetta, C, Valsecchi, M, Vicenzi, M, Zanchetta, G, Milani G. P., Montomoli E., Bollati V., Albetti B., Bandi C., Bellini T., Bonzini M., Buscaglia M., Cantarella C., Cantone L., Carugno M., Casartelli S., Cavaletti G., D'Alessandro S., De Chiara F., Delbue S., Dioni L., Eberini I., Favero C., Ferrari L., Ferraroni M., Galastri L., Galli C., Hoxha M., Iodice S., La Vecchia C., Macchi C., Manini I., Marchi S., Mariani J., Pariani E., Pesatori A. C., Rota F., Ruscica M., Schioppo T., Tarantini L., Trombetta C. M., Valsecchi M. G., Vicenzi M., and Zanchetta G.
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- 2020
43. Long-Chain Polyunsaturated Fatty Acid Concentrations in Human Hindmilk are Constant Throughout Twelve Months of Lactation
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Agostoni, C., Marangoni, F., Lammardo, A. M., Galli, C., Giovannini, M., Riva, E., and Newburg, David S., editor
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- 2001
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44. Prolonged Breast-Feeding (Six Months or More) and Milk Fat Content at Six Months are Associated with Higher Developmental Scores at One Year of Age Within a Breast-Fed Population
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Agostoni, C., Marangoni, F., Giovannini, M., Galli, C., Riva, E., and Newburg, David S., editor
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- 2001
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45. SCCS OPINION on the safety of alpha-arbutin and beta-arbutin in cosmetic products - SCCS/1642/22 – Preliminary Opinion
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraad, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Granum, B., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Cabaton, N., Koutsodimou, A., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Direction des affaires européennes et internationales (DAEI), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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alpha-arbutin ,SCCS ,Regulation 1223/2009 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,beta-arbutin ,scientific opinion - Abstract
International audience; SCCS OPINION on the safety of alpha-arbutin and beta-arbutin in cosmetic products - SCCS/1642/22 – Preliminary OpinionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraad, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzThe SCCS adopted this document at its plenary meeting on 15 and 16 March 2022 (70 Pages)Mise en ligne 26 Mars 2022https://ec.europa.eu/health/publications/safety-alpha-arbutin-and-beta-arbutin-cosmetic-products_en DetailsPublication date25 March 2022AuthorScientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli, B. Granum, E. Panteri, V. Rogiers (Rapporteur), Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzContact:SANTE-C2-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1642/22Adopted on: 15-16 March 2022Conclusion of the opinion: (1) In light of the data provided, does the SCCS consider α-arbutin safe when used in face creams up to a maximum concentration of 2% and in body lotions up to a maximum concentration of 0.5 %?Having considered the data provided, and other relevant information available in scientific literature, the SCCS cannot conclude on the safety of alpha-arbutin when used in face creams up to a maximum concentration of 2% and in body lotions up to a maximum concentration of 0.5%. Relevant data on the degradation/metabolism of alpha-arbutin, exposed to the skin microbiome/enzymes, are not available and the release of hydroquinone and its final fate are not documented. These data are essentially required for safety assessment.(2) In the event that the estimated exposure to α-arbutin from cosmetic products is found to be of concern, SCCS is asked to recommend safe concentration limits.For the reasons given under question 1, the SCCS cannot recommend a safe concentration of alpha-arbutin.(3) In light of the data provided, does the SCCS consider β-arbutin safe when used in face creams up to a maximum concentration of 7%?No information was provided during the call for data. The SCCS has, therefore, considered the information available in scientific literature but regarded it insufficient to conclude on the safety of beta-arbutin when used in face cream up to a maximum concentration of 7%. Also, relevant data on the fate of beta-arbutin, when applied to human skin and its microbiome/enzymes, are not available and the release of hydroquinone and its final fate are not documented.(4) In the event that the estimated exposure to β-arbutin from cosmetic products is found to be of concern, SCCS is asked to recommend safe concentration limits.For the reasons given under question 3, the SCCS cannot recommend a safe concentration of beta-arbutin.(5) In light of the data provided, does the SCCS consider that the presence of hydroquinone in the cosmetic formulations must remain below 1 ppm for both α- and β arbutin containing products?Hydroquinone should remain as low as possible in formulations containing alpha-or beta arbutin and should not be higher than the unavoidable traces in both arbutins. In the new studies, submitted by the applicant, 3ppm was the LOQ/LOD of the methodology used.(6) Does the SCCS have any further scientific concerns regarding the use of a- and β arbutin in cosmetic products in relation to aggregate exposure from such substances in cosmetics?Safe concentrations for either of the arbutins in cosmetic products cannot be established without the data on the release of hydroquinone and their final fate.Keywords:SCCS, scientific opinion, alpha-arbutin, beta-arbutin, Regulation 1223/2009Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on the safety of alpha- (CAS No. 84380-018, EC No. 617-561-8) and beta-arbutin (CAS No. 497- 76-7, EC No. 207-8503) in cosmetic products, preliminary version of 15-16 March 2022, SCCS/1642/22
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- 2022
46. SCIENTIFIC ADVICE ON the safety of Triclocarban and Triclosan as substances with potential endocrine disrupting properties in cosmetic products
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraad, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Granum, B., Panteri, E., Rogiers, V., Rousselle, Christophe, Stepnik, M., Vanhaecke, T., Wijnhoven, S., Cabaton, N., Koutsodimou, A., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Direction des affaires européennes et internationales (DAEI), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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SCCS ,EC No. 202-924-1 ,Regulation 1223/2009 ,CAS No. 101-20-2 ,EC No. 222-182-2 ,Triclocarban ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,scientific advice ,Triclosan ,CAS No. 3380-34-5 - Abstract
International audience; "SCIENTIFIC ADVICE ON the safety of Triclocarban and Triclosan as substances with potential endocrine disrupting properties in cosmetic products"SCCS/1643/22 - Scientific AdviceU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraad, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzThe SCCS adopted this document at its plenary meeting on 15 and 16 March 2022 (51 Pages)Mise en ligne 26 Mars 2022https://ec.europa.eu/health/publications/safety-triclocarban-and-triclosan-substances-potential-endocrine-disrupting-properties-cosmetic_enDetailsPublication date25 March 2022AuthorScientific Committee on Consumer Safety (SCCS)DescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli, B. Granum (Rapporteur), E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. WijnhovenSCCS external experts: N. Cabaton, A. Koutsodimou, W. Uter, N. von GoetzContact:SANTE-C2-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1643/22Adopted on: 15-16 March 2022Conclusion of the opinion:In light of the information submitted via the call for data, the currently available scientific literature, relevant in silico tools and SCCS’ expert judgement and taking under consideration in particular the concerns related to potential endocrine disrupting properties, the SCCS is requested:1. to identify and justify specific concerns regarding the safe use of Triclocarban and Triclosan in cosmetic productsBased on the safety assessment carried out in consideration of all available information, including the potential endocrine effects, the SCCS is of the opinion that:- The use of Triclocarban as a preservative in cosmetic products is safe up to a maximum concentration of 0.2%.- In addition to the preservative function, the use of Triclocarban is also safe up to a maximum concentration of 1.5% in rinse-off products when used individually or in combination.- The use of Triclosan is safe as a preservative up to a maximum concentration of 0.03% in shower gel and hand soap, 0.2% in mouthwash, and 0.3% in toothpaste, deodorant stick, face powder and blemish concealer, when used individually or in combination.- The use of Triclosan is not considered safe as a preservative up to a maximum concentration of 0.3% in body lotion when used individually or in combination. The use of Triclosan in body lotion is considered safe when its concentration does not exceed 0.03% when used individually or combined with the above-mentioned products.The SCCS is not aware of the use of Triclocarban and Triclosan together in a single product, and therefore this has not been assessed.2. to highlight if there is a potential risk for human health from the use of Triclocarban and Triclosan in cosmetic products/Keywords:SCCS, scientific advice, Triclocarban, Triclosan, Regulation 1223/2009, CAS No. 101-20-2, EC No. 202-924-1, CAS No. 3380-34-5, EC No. 222-182-2Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Scientific advice, Request for a scientific advice on the safety of Triclocarban (CAS No. 101-20-2, EC No. 202- 924-1) and Triclosan (CAS No. 3380-34-5, EC No. 222-182-2) as substances with potential endocrine disrupting properties used in cosmetic products, preliminary version of 15-16 March 2022, SCCS/1643/22
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- 2022
47. SCCS Opinion on Kojic Acid - SCCS/1637/21 - Final version
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraad, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Granum, B., Panteri, E., Rogiers, V., Rousselle, Ch., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Koutsodimou, A., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Scientific Committee for Consumer Safety (SCCS, EC), and Gaffet, Eric
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SCCS ,revision ,Kojic acid ,Regulation 1223/2009 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,CAS No 501-30-4 ,EC No 207-922-4 ,[PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,scientific opinion - Abstract
International audience; SCCS Opinion on Kojic Acid - SCCS/1637/21 - Final versionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraad, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, A. Koutsodimou, W. Uter, N. von GoetzThe SCCS adopted this document at its plenary meeting on 15 and 16 March 2022 (85 Pages)Mise en ligne 17 Mars 2022https://ec.europa.eu/health/publications/kojic-acid_enDescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli, B. Granum, E. Panteri, V. Rogiers (Rapporteur), Ch. Rousselle, M. Stepnik, T. Vanhaecke (Rapporteur), S. WijnhovenSCCS external experts: A. Koutsodimou, W. Uter, N. von GoetzContact:SANTE-C2-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1637/21Adopted on: 15-16 March 2022Conclusion of the opinion:(1) In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of Kojic acid, does the SCCS consider Kojic acid safe when used in cosmetic products up to a maximum concentration of 1 %?On the basis of the safety assessment, and considering the concerns related to potential endocrine disrupting properties of Kojic acid, the SCCS is of the opinion that Kojic acid is not safe when used as a skin lightening agent in cosmetic products at concentrations of up to 1%.(2) Alternatively, what is according to the SCCS the maximum concentration considered safe for use of Kojic acid in cosmetic products?In the SCCS’s opinion, the use of Kojic acid as a skin lightening agent in cosmetic products is safe for the consumer up to a maximum concentration of 0.7% Kojic acid in the final product.(3) Does the SCCS have any further scientific concerns with regard to the use of Kojic acid in cosmetic products?As Kojic acid is sometimes added to peeling agents, a weakened skin barrier may be of additional concern because of greater dermal absorption.Only the topical use of Kojic acid in cosmetics has been considered in this Opinion. Other uses (e.g. food) of natural or synthetic sources have not been considered.As far as the derivatives of Kojic acid are concerned, e.g. esters of Kojic acid such as Kojic acid dipalmitate and Kojic acid isopalmitate, and derivatives such as chloro-Kojic acid, these have not been included in this Opinion as no data has been submitted.Keywords:SCCS, revision, scientific opinion, Kojic acid, CAS No 501-30-4, EC No 207-922-4, Regulation 1223/2009Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), scientific opinion on Kojic acid, preliminary version of 26-27 October 2021, final version of 15-16 March 2022, SCCS/1637/21.
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- 2022
48. SCCS OPINION on Prostaglandins and their analogues used in cosmetic products - SCCS/1635/21 - Final version
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Bernauer, U., Bodin, L., Chaudhry, Q., Coenraads, P.J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Granum, B., Panteri, E., Rogiers, V., Rousselle, Christophe, Stepnik, M., Vanhaecke, T., Wijnhoven, S., Koutsodimou, A., Uter, W., Goetz, N. Von, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Scientific Committee for Consumer Safety (SCCS) (SCCS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Direction des affaires européennes et internationales (DAEI), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Scientific Committee for Consumer Safety (SCCS, EC)
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prostaglandins ,SCCS ,Regulation 1223/2009 ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,scientific opinion - Abstract
International audience; SCCS OPINION on Prostaglandins and their analogues used in cosmetic products - SCCS/1635/21 - Final versionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, A. Koutsodimou, W. Uter, N. von GoetzThe SCCS adopted this document by written procedure on 3 February 2022 (41 pages)Mise en Ligne 4 February 2022https://ec.europa.eu/health/publications/prostaglandins-and-prostaglandin-analogues-used-cosmetic-products_enAuthorDirectorate-General for Health and Food SafetyDescriptionSCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C.L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik (Rapporteur), T. Vanhaecke, S. WijnhovenSCCS external experts: A. Koutsodimou, W. Uter, N. von GoetzContact:SANTE-C2-SCCS@ec.europa.euOn request from: European CommissionSCCS Number: SCCS/1635/21Adopted on: 3 Februrary 2022Conclusion of the opinion: (1) In light of the data provided, does the SCCS consider Isopropyl cloprostenate (CAS 157283-66-4) and Ethyl Tafluprostamide or DDDE (CAS 1185851-52-8) safe when used up to the concentrations provided in the respective dossiers (0.006% and 0.007% for Isopropyl cloprostenate and 0.018% for Ethyl Tafluprostamide)Having considered the limited data provided and the available information from published literature, the SCCS is not able to conclude on the safety of isopropyl cloprostenate and ethyl tafluprostamide when used up to the intended use concentrations indicated in the respective dossiers (0.006% and 0.007% for isopropyl cloprostenate and 0.018% for ethyl tafluprostamide).(2) Does the SCCS have any further scientific concerns with regard to the use of Isopropyl cloprostenate (CAS 157283-66-4) and Ethyl Tafluprostamide / DDDE (CAS 1185851-52-8) in cosmetic products?The SCCS has noted concerns about the safety of isopropyl cloprostenate and ethyl tafluprostamide when used in cosmetic products - in particular those that are intended for use in the proximity of the eye. These concerns have been highlighted in more detail in Annex 1.(3) In light of the available data, does the SCCS consider that the use in cosmetic products of prostaglandins analogues (listed in Table 1) raises safety concerns and might pose a risk to human health?Prostaglandins and synthetic analogues are widely known to be potent pharmacologically active substances. Due to these effects, other regulatory authorities have advised against, or have prohibited, their use in eyelash growth-promoting cosmetics. In view of the potential for causing effects at very low concentrations, and the intended use in the proximity of the eye, the SCCS has noted concerns over the safety of prostaglandin analogues when used in cosmetic products. These have been highlighted in Annex 1 to this Opinion.Keywords:SCCS, scientific opinion, prostaglandins, Regulation 1223/2009Opinion to be cited as:SCCS (Scientific Committee on Consumer Safety), Opinion on Prostaglandins and prostaglandin-analogues used in cosmetic products, preliminary version of 27 September 2021, final version of 3 February 2022, SCCS/1635/21.
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- 2022
49. Ethical Analysis of the Application of Assisted Reproduction Technologies in Biodiversity Conservation and the Case of White Rhinoceros (Ceratotherium simum) Ovum Pick-Up Procedures.
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Biasetti, P, Hildebrandt, TB, Göritz, F, Hermes, R, Holtze, S, Galli, C, Lazzari, G, Colleoni, S, Pollastri, I, Spiriti, MM, Stejskal, J, Seet, S, Zwilling, J, Ngulu, S, Mutisya, S, Kariuki, L, Lokolool, I, Omondo, P, Ndeereh, D, de Mori, B, Biasetti, P, Hildebrandt, TB, Göritz, F, Hermes, R, Holtze, S, Galli, C, Lazzari, G, Colleoni, S, Pollastri, I, Spiriti, MM, Stejskal, J, Seet, S, Zwilling, J, Ngulu, S, Mutisya, S, Kariuki, L, Lokolool, I, Omondo, P, Ndeereh, D, and de Mori, B
- Abstract
Originally applied on domestic and lab animals, assisted reproduction technologies (ARTs) have also found application in conservation breeding programs, where they can make the genetic management of populations more efficient, and increase the number of individuals per generation. However, their application in wildlife conservation opens up new ethical scenarios that have not yet been fully explored. This study presents a frame for the ethical analysis of the application of ART procedures in conservation based on the Ethical Matrix (EM), and discusses a specific case study-ovum pick-up (OPU) procedures performed in the current conservation efforts for the northern white rhinoceros (Ceratotherium simum cottoni)-providing a template for the assessment of ART procedures in projects involving other endangered species.
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50. Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
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Zywitza, V, Rusha, E, Shaposhnikov, D, Ruiz-Orera, J, Telugu, N, Rishko, V, Hayashi, M, Michel, G, Wittler, L, Stejskal, J, Holtze, S, Göritz, F, Hermes, R, Wang, J, Izsvák, Z, Colleoni, S, Lazzari, G, Galli, C, Hildebrandt, TB, Hayashi, K, Diecke, S, Drukker, M, Zywitza, V, Rusha, E, Shaposhnikov, D, Ruiz-Orera, J, Telugu, N, Rishko, V, Hayashi, M, Michel, G, Wittler, L, Stejskal, J, Holtze, S, Göritz, F, Hermes, R, Wang, J, Izsvák, Z, Colleoni, S, Lazzari, G, Galli, C, Hildebrandt, TB, Hayashi, K, Diecke, S, and Drukker, M
- Abstract
The northern white rhinoceros (NWR) is probably the earth's most endangered mammal. To rescue the functionally extinct species, we aim to employ induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro. To elucidate the regulation of pluripotency and differentiation of NWR PSCs, we generated iPSCs from a deceased NWR female using episomal reprogramming, and observed surprising similarities to human PSCs. NWR iPSCs exhibit a broad differentiation potency into the three germ layers and trophoblast, and acquire a naïve-like state of pluripotency, which is pivotal to differentiate PSCs into primordial germ cells (PGCs). Naïve culturing conditions induced a similar expression profile of pluripotency related genes in NWR iPSCs and human ESCs. Furthermore, naïve-like NWR iPSCs displayed increased expression of naïve and PGC marker genes, and a higher integration propensity into developing mouse embryos. As the conversion process was aided by ectopic BCL2 expression, and we observed integration of reprogramming factors, the NWR iPSCs presented here are unsuitable for gamete production. However, the gained insights into the developmental potential of both primed and naïve-like NWR iPSCs are fundamental for in future PGC-specification in order to rescue the species from extinction using cryopreserved somatic cells.
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- 2022
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