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OBJECTIVE: This study sought to examine the effects of a 3-month programme of dietary advice to restrict carbohydrate intake compared with reduced-portion, low-fat advice in obese subjects with poorly controlled Type 2 diabetes. RESEARCH DESIGN AND METHODS: One hundred and two patients with Type 2 diabetes were recruited across three centres and randomly allocated to receive group education and individual dietary advice. Weight, glycaemic control, lipids and blood pressure were assessed at baseline and 3 months. Dietary quality was assessed at the end of study. RESULTS: Weight loss was greater in the low-carbohydrate (LC) group (-3.55 +/- 0.63, mean +/- sem) vs. -0.92 +/- 0.40 kg, P = 0.001) and cholesterol : high-density lipoprotein (HDL) ratio improved (-0.48 +/- 0.11 vs. -0.10 +/- 0.10, P = 0.01). However, relative saturated fat intake was greater (13.9 +/- 0.71 vs. 11.0 +/- 0.47% of dietary intake, P < 0.001), although absolute intakes were moderate. CONCLUSIONS: Carbohydrate restriction was an effective method of achieving short-term weight loss compared with standard advice, but this was at the expense of an increase in relative saturated fat intake. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the impact of a pre-emptive apnoea triggered oxygen response on oxygen saturation (SpO 2 ) targeting following central apnoea in preterm infants., Design: Interventional crossover study of a 12-hour period of automated oxygen control with an apnoea response (AR) module, nested within a crossover study of a 24-hour period of automated oxygen control compared with aggregated data from two flanking 12-hour periods of manual control., Setting: Neonatal intensive care unit PATIENTS: Preterm infants receiving non-invasive respiratory support and supplemental oxygen; median (IQR) birth gestation 27 (26-28) weeks, postnatal age 17 (12-23) days., Intervention: Automated oxygen titration with an automated control algorithm modified to include an AR module. Alterations to inspired oxygen concentration (FiO 2 ) were actuated by a motorised blender. Desired SpO 2 range was 90-94%. Apnoea detection was by capsule pneumography., Main Outcome Measures: Duration, magnitude and area under the curve (AUC) of SpO 2 deviations following apnoea; frequency and duration of apnoeic events. Comparisons between periods of manual, automated and automated control with AR module., Results: In 60 studies in 35 infants, inclusion of the AR module significantly reduced AUC for SpO 2 deviations below baseline compared with both automated and manual control (manual: 87.1%±107.6% s, automated: 84.6%±102.8% s, AR module: 79.4%±102.7% s). However, there was a coincident increase in SpO 2 overshoot (AUC (SpO 2 >SpO 2(onset) ); manual: 44.3±99.9% s, automated: 54.7%±103.4% s, AR module: 65.7%±126.2% s)., Conclusion: Automated control with a pre-emptive apnoea-triggered FiO 2 boost resulted in a modest reduction in post-apnoea hypoxaemia, but was followed by a greater SpO 2 overshoot., Trial Registration Number: ACTRN12616000300471., Competing Interests: Competing interests: The University of Tasmania and Royal Hobart Hospital have jointly lodged a patent application concerning automated control of inspired oxygen concentration in the newborn infant. TJG and PAD are named inventors. The authors have no other conflicts of interest relevant to this article to disclose., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)

Objective: To examine the effectiveness of a noncontact vision-based infrared respiratory monitor (IRM) in the detection of authentic respiratory motion in newborn infants., Study Design: Observational study in a neonatal intensive care unit., Methods: Eligible infants lay supine with torso exposed under the IRM's infrared depth-map camera and torso images were recorded at 30 frames/s. Respiratory motion waveforms were subsequently derived from upper (IRM upper ) and lower (IRM lower ) torso region images and compared with contemporaneous impedance pneumography (IP) and capsule pneumography (CP). Waveforms, in 15 s investigative epochs, were scanned with an 8 s sliding window for authentic respiratory waveform (spectral purity index [SPI] ≥ 0.75, minimum five complete breaths). Maximum SPI and frequency of occurrence of authentic respiratory waveform in 15 s epochs were compared between monitoring modalities in pooled and per patient data (Friedman ANOVA)., Results: Recordings comprised 532 min of images from 35 infants, yielding 2131 investigative epochs, with authentic respiratory motion detected in all infants. For CP, IP, IRM upper , and IRM lower , the proportion of epochs containing authentic respiratory motion in pooled data were 65%, 50%, 36%, and 48%, with median SPI max of 0.79, 0.75, 0.70, and 0.74, respectively. Per-patient average SPI max was 0.79, 0.75, 0.69, and 0.74 for CP, IP, IRM upper , and IRM lower with proportion of authentic respiratory motion being 64%, 50%, 29%, and 49%, respectively., Conclusion: An IRM focused on the lower torso detected authentic respiratory motion with comparable performance to IP in newborn infants in intensive care and deserves further investigation., (© 2023 Wiley Periodicals LLC.)

Objective: To study the feasibility of automated titration of oxygen therapy in the delivery room for preterm infants., Design: Prospective non-randomised study of oxygenation in sequential preterm cohorts in which FiO 2 was adjusted manually or by an automated control algorithm during the first 10 min of life., Setting: Delivery rooms of a tertiary level hospital., Participants: Preterm infants <32 weeks gestation (n=20 per group)., Intervention: Automated oxygen control using a purpose-built device, with SpO 2 readings input to a proportional-integral-derivative algorithm, and FiO 2 alterations actuated by a motorised blender. The algorithm was developed via in silico simulation using abstracted oxygenation data from the manual control group. For both groups, the SpO 2 target was the 25th-75th centile of the Dawson nomogram., Main Outcome Measures: Proportion of time in the SpO 2 target range (25th-75th centile, or above if in room air) and other SpO 2 ranges; FiO 2 adjustment frequency; oxygen exposure., Results: Time in the SpO 2 target range was similar between groups (manual control: median 60% (IQR 48%-72%); automated control: 70 (60-84)%; p=0.31), whereas time with SpO 2 >75th centile when receiving oxygen differed (manual: 17 (7.6-26)%; automated: 10 (4.4-13)%; p=0.048). Algorithm-directed FiO 2 adjustments were frequent during automated control, but no manual adjustments were required in any infant once valid SpO 2 values were available. Oxygen exposure was greater during automated control, but final FiO 2 was equivalent., Conclusion: Automated oxygen titration using a purpose-built algorithm is feasible for delivery room management of preterm infants, and warrants further evaluation., Competing Interests: Competing interests: The University of Tasmania holds a patent concerning a method, apparatus and system for automatically controlling inspired oxygen delivery. An oxygen control algorithm (VDL1.1) has been incorporated as the OxyGenie automated oxygen titration system in the SLE6000 infant ventilator (SLE, South Croydon, UK)., (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)

Apnoea, a pause in respiration, is ubiquitous in preterm infants and are often associated with physiological instability, which may lead to longer-term adverse neurodevelopmental consequences. Despite current therapies aimed at reducing the apnoea burden, preterm infants continue to exhibit apnoeic events throughout their hospital admission. Bedside staff are frequently required to manually intervene with different forms of stimuli, with the aim of re-establishing respiratory cadence and minimizing the physiological impact of each apnoeic event. Such a reactive approach makes apnoea and its associated adverse consequences inevitable and places a heavy reliance on human intervention. Different approaches to improving apnoea management in preterm infants have been investigated, including the use of various sensory stimuli. Despite studies reporting sensory stimuli of various forms to have potential in reducing apnoea frequency, non-invasive intermittent positive pressure ventilation is the only automated stimulus currently used in the clinical setting for infants with persistent apnoeic events. We find that the development of automated closed-looped sensory stimulation systems for apnoea mitigation in preterm infants receiving non-invasive respiratory support is warranted, including the possibility of stimulation being applied preventatively, and in a multi-modal form. IMPACT: This review examines the effects of various forms of sensory stimulation on apnoea mitigation in preterm infants, namely localized tactile, generalized kinesthetic, airway pressure, auditory, and olfactory stimulations. Amongst the 31 studies reviewed, each form of sensory stimulation showed some positive effects, although the findings were not definitive and comparative studies were lacking. We find that the development of automated closed-loop sensory stimulation systems for apnoea mitigation is warranted, including the possibility of stimulation being applied preventatively, and in a multi-modal form., (© 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)

Objective: To compare the effect of two different automated oxygen control devices on target range (TR) time and occurrence of hypoxaemic and hyperoxaemic episodes., Design: Randomised cross-over study., Setting: Tertiary level neonatal unit in the Netherlands., Patients: Preterm infants (n=15) born between 24+0 and 29+6 days of gestation, receiving invasive or non-invasive respiratory support with oxygen saturation (SpO 2 ) TR of 91%-95%. Median gestational age 26 weeks and 4 days (IQR 25 weeks 3 days-27 weeks 6 days) and postnatal age 19 (IQR 17-24) days., Interventions: Inspired oxygen concentration was titrated by the OxyGenie controller (SLE6000 ventilator) and the CLiO 2 controller (AVEA ventilator) for 24 hours each, in a random sequence, with the respiratory support mode kept constant., Main Outcome Measures: Time spent within set SpO 2 TR (91%-95% with supplemental oxygen and 91%-100% without supplemental oxygen)., Results: Time spent within the SpO 2 TR was higher during OxyGenie control (80.2 (72.6-82.4)% vs 68.5 (56.7-79.3)%, p<0.005). Less time was spent above TR while in supplemental oxygen (6.3 (5.1-9.9)% vs 15.9 (11.5-30.7)%, p<0.005) but more time spent below TR during OxyGenie control (14.7 (11.8%-17.2%) vs 9.3 (8.2-12.6)%, p<0.05). There was no significant difference in time with SpO 2 <80% (0.5 (0.1-1.0)% vs 0.2 (0.1-0.4)%, p=0.061). Long-lasting SpO 2 deviations occurred less frequently during OxyGenie control., Conclusions: The OxyGenie control algorithm was more effective in keeping the oxygen saturation within TR and preventing hyperoxaemia and equally effective in preventing hypoxaemia (SpO 2 <80%), although at the cost of a small increase in mild hypoxaemia., Trial Registry Number: NCT03877198., Competing Interests: Competing interests: ABtP has received an unrestricted research grant from SLE Limited; they had no role in study design nor in the collection, analysis, and interpretation of data, writing of the report and decision to submit the paper for publication. The University of Tasmania and Royal Hobart Hospital have a patent concerning automated control of inspired oxygen concentration in the new-born infant and have a licensing agreement with SLE Limited in relation to OxyGenie automated oxygen control software., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Objective: To evaluate the performance of a rapidly responsive adaptive algorithm (VDL1.1) for automated oxygen control in preterm infants with respiratory insufficiency., Design: Interventional cross-over study of a 24-hour period of automated oxygen control compared with aggregated data from two flanking periods of manual control (12 hours each)., Setting: Neonatal intensive care unit., Participants: Preterm infants receiving non-invasive respiratory support and supplemental oxygen; median birth gestation 27 weeks (IQR 26-28) and postnatal age 17 (12-23) days., Intervention: Automated oxygen titration with the VDL1.1 algorithm, with the incoming SpO 2 signal derived from a standard oximetry probe, and the computed inspired oxygen concentration (FiO 2 ) adjustments actuated by a motorised blender. The desired SpO 2 range was 90%-94%, with bedside clinicians able to make corrective manual FiO 2 adjustments at all times., Main Outcome Measures: Target range (TR) time (SpO 2 90%-94% or 90%-100% if in air), periods of SpO 2 deviation, number of manual FiO 2 adjustments and oxygen requirement were compared between automated and manual control periods., Results: In 60 cross-over studies in 35 infants, automated oxygen titration resulted in greater TR time (manual 58 (51-64)% vs automated 81 (72-85)%, p<0.001), less time at both extremes of oxygenation and considerably fewer prolonged hypoxaemic and hyperoxaemic episodes. The algorithm functioned effectively in every infant. Manual FiO 2 adjustments were infrequent during automated control (0.11 adjustments/hour), and oxygen requirements were similar (manual 28 (25-32)% and automated 26 (24-32)%, p=0.13)., Conclusion: The VDL1.1 algorithm was safe and effective in SpO 2 targeting in preterm infants on non-invasive respiratory support., Trial Registration Number: ACTRN12616000300471., Competing Interests: Competing interests: The University of Tasmania and Tasmanian Health Service have jointly lodged a patent application concerning automated control of inspired oxygen concentration in the newborn infant, and have entered into a licensing agreement with SLE Limited allowing use of the VDL1.1 algorithm (as OxyGenie) in SLE respiratory support devices., (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)

For the preterm infant with respiratory insufficiency requiring supplemental oxygen, tight control of oxygen saturation (SpO 2 ) is advocated, but difficult to achieve in practice. Automated control of oxygen delivery has emerged as a potential solution, with six control algorithms currently embedded in commercially-available respiratory support devices. To date, most clinical evaluations of these algorithms have been short-lived crossover studies, in which a benefit of automated over manual control of oxygen titration has been uniformly noted, along with a reduction in severe SpO 2 deviations and need for manual FiO 2 adjustments. A single non-randomised study has examined the effect of implementation of automated oxygen control with the CLiO 2 algorithm as standard care for preterm infants; no clear benefits in relation to clinical outcomes were noted, although duration of mechanical ventilation was lessened. The results of randomised controlled trials are awaited. Beyond the gathering of evidence regarding a treatment effect, we contend that there is a need for a better understanding of the function of contemporary control algorithms under a range of clinical conditions, further exploration of techniques of adaptation to individualise algorithm performance, and a concerted effort to apply this technology in low resource settings in which the majority of preterm infants receive care. Attainment of these goals will be paramount in optimisation of oxygen therapy for preterm infants globally., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Background: Nasal continuous positive airway pressure (NCPAP) can be applied via binasal prongs or nasal masks; both may be associated with air leak and intermittent hypoxia. We investigated whether the latter is more frequent with nasal masks or prongs., Methods: Continuous 24 hours recordings of inspired oxygen fraction (FiO 2 ), pulse rate, respiratory rate, pulse oximeter saturation (SpO 2 ) and CPAP level were made in preterm infants with respiratory insufficiency (n=20) managed on CPAP in the NICU at the Royal Hobart Hospital. As part of routine care, nasal interfaces were alternated 4-hourly between mask and prongs. In each recording, the first two segments containing at least 3 hours of artefact-free signal for each interface were selected. Recordings were analysed for episodes with hypoxaemia (SpO 2 <80% for ≥10 s) and bradycardia (pulse rate <80/min for ≥4 s) and for episodes of pressure loss at the nasal interface. Data were compared using Wilcoxon-matched pairs test and are reported as median (IQR)., Results: Infants had a gestational age at birth of 26 (25-27) weeks and postnatal age of 17 (14-24) days. There was no difference in %time with interface leak between prong and mask (0.9 (0-8)% vs 1.1 (0-18)%, p=0.82), %time with SpO 2 <80% (0.15 (0-1.2)% vs 0.06 (0-0.8)%, p=0.74) or heart rate <80/min (0.03 (0-0.2)% vs 0 (0-0.2)%, p=0.64). Three infants had interface leak for >10% of the time with prongs and 5 with the mask., Conclusion: Both interfaces resulted in a similarly stable provision of positive airway pressure, and there was also no difference in the occurrence of intermittent hypoxia., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.)

Apnoea, a pause in respiration, is almost ubiquitous in preterm infants born before completing 30 weeks gestation. Apnoea often begets hypoxemia and/or bradycardia, and has the potential to result in adverse neurodevelopmental consequences. Our current inability to predict apnoeic events in preterm infants requires apnoea to first be detected by monitoring device/s in order to trigger an intervention by bedside (medical or nursing) staff. Such a reactive management approach is laborious, and makes the consequences of apnoeic events inevitable. Recent technological advances and improved signal processing have allowed the possibility of developing prediction models for apnoeic events in preterm infants. However, the development of such models has numerous challenges and is only starting to show potential. This paper identifies requisite components and current gaps in developing prediction models for apnoeic events, and reviews previous studies on predicting apnoeic events in preterm infants., (Copyright © 2020 Lim, Jiang, Marshall, Salmon, Gale and Dargaville.)

Sexual conflict may be manifested during social interactions, shaping the costs of reproduction in sexually reproducing species. This conflict, and the physical necessity of intromission, can intensify the already costly nature of reproduction for female mammals. To identify and partition the costs that males inflict on females during mating and reproduction, we paired female mice with either other females or castrated, vasectomised, or intact (sham-vasectomised) males, thus manipulating exposure to social mating behavior and costs arising from fertilization. We also provided females with refuges where males could not enter, to test whether females show avoidance or attraction to males of different gonadal status expected to exhibit different levels of social behavior. We found that females paired with vasectomised and castrated males spent the most time in their refuge. Females housed with castrated males also had increased glucocorticoid levels, an effect that was mitigated when females could retreat from these males to a refuge. This suggests that females actively refuge from castrated males, and that housing with such males is sufficient to generate an increased glucocorticoid response. Our results show that females choose to refuge from males depending on the partner's gonadal status, choices that are linked to social induced stress responses but not exposure to male mating behaviour., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Background: The factors influencing the severity of apnea-related hypoxemia and bradycardia are incompletely characterized, especially in infants receiving noninvasive respiratory support., Objectives: To identify the frequency and predictors of physiological instability (hypoxemia-oxygen saturation (SpO 2 ) <80%, or bradycardia-heart rate (HR) < 100 bpm) following respiratory pauses in infants receiving noninvasive respiratory support., Methods: Respiratory pause duration, derived from capsule pneumography, was measured in 30 preterm infants of gestation 30 (24-32) weeks [median (interquartile range)] receiving noninvasive respiratory support and supplemental oxygen. For identified pauses of 5 to 29 seconds duration, we measured the magnitude and duration of SpO 2 and HR reductions over a period starting at the pause onset and ending 60 seconds after resumption of breathing. Temporally clustered pauses (<60 seconds separation) were analyzed separately. The relative contribution of respiratory pauses to overall physiological instability was determined, and predictors of instability were sought in regression analysis, including demographic, clinical and situational variables as inputs., Results: In total, 17 105 isolated and 9180 clustered pauses were identified. Hypoxemia and bradycardia were more likely after longer duration and temporally-clustered pauses. However, the majority of such episodes occurred after 5 to 9 second pauses given their numerical preponderance, and short-lived pauses made a substantial contribution to physiological instability overall. Birth gestation, hemoglobin concentration, form of respiratory support, caffeine treatment, respiratory pause duration and temporal clustering were identified as predictors of instability., Conclusions: Brief respiratory pauses, especially when clustered, contribute substantially to hypoxemia and bradycardia in preterm infants., (© 2019 Wiley Periodicals, Inc.)

Imaging systems have applications in patient respiratory monitoring but with limited application in neonatal intensive care units (NICU). In this paper we propose an algorithm to automatically detect the torso in an image of a preterm infant during non-invasive respiratory monitoring. The algorithm uses normalised cut to segment each image into clusters, followed by two fuzzy inference systems to detect the nappy and torso. Our dataset comprised overhead images of 16 preterm infants in a NICU, with uncontrolled illumination, and encompassing variations in poses, presence of medical equipment and clutter in the background. The algorithm successfully identified the torso region for 15 of the 16 images, with a high agreement between the detected torso and the torso identified by clinical experts.

Objective: To evaluate the performance of a novel rapidly responsive proportional-integral-derivative (PID) algorithm for automated oxygen control in preterm infants with respiratory insufficiency., Design: Interventional study of a 4-hour period of automated oxygen control compared with combined data from two flanking periods of manual control (4 hours each)., Setting: Neonatal intensive care unit., Participants: Preterm infants (n=20) on non-invasive respiratory support and supplemental oxygen, with oxygen saturation (SpO 2 ) target range 90%-94% (manual control) and 91%-95% (automated control). Median gestation at birth 27.5 weeks (IQR 26-30 weeks), postnatal age 8.0 (1.8-34) days., Intervention: Automated oxygen control using a standalone device, receiving SpO 2 input from a standard oximeter and computing alterations to oxygen concentration that were actuated with a modified blender. The PID algorithm was enhanced to avoid iatrogenic hyperoxaemia and adapt to the severity of lung dysfunction., Main Outcome Measure: Proportion of time in the SpO 2 target range, or above target range when in air., Results: Automated oxygen control resulted in more time in the target range or above in air (manual 56 (48-63)% vs automated 81 (76-90)%, p<0.001) and less time at both extremes of oxygenation. Prolonged episodes of hypoxaemia and hyperoxaemia were virtually eliminated. The control algorithm showed benefit in every infant. Manual changes to oxygen therapy were infrequent during automated control (0.24/hour vs 2.3/hour during manual control), and oxygen requirements were unchanged (automated control period 27%, manual 27% and 26%, p>0.05)., Conclusions: The novel PID algorithm was very effective for automated oxygen control in preterm infants, and deserves further investigation., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)

Objective: To assess the performance of a novel algorithm for automated oxygen control using a simulation of oxygenation founded on in vivo data from preterm infants., Methods: A proportional-integral-derivative (PID) control algorithm was enhanced by (i) compensation for the non-linear SpO 2 -PaO 2 relationship, (ii) adaptation to the severity of lung dysfunction and (iii) error attenuation within the target range. Algorithm function with and without enhancements was evaluated by iterative linking with a computerised simulation of oxygenation. Data for this simulation (FiO 2 and SpO 2 at 1 Hz) were sourced from extant recordings from preterm infants (n=16), and converted to a datastream of values for ventilation:perfusion ratio and shunt. Combination of this datastream second by second with the FiO 2 values from the algorithm under test produced a sequence of novel SpO 2 values, allowing time in the SpO 2 target range (91%-95%) and in various degrees of hypoxaemia and hyperoxaemia to be determined. A PID algorithm with 30 s lockout after each FiO 2 adjustment, and a proportional-derivative (PD) algorithm were also evaluated., Results: Separate addition of each enhancing feature to the PID algorithm showed a benefit, but not with uniformly positive effects. The fully enhanced algorithm was optimal for the combination of targeting the desired SpO 2 range and avoiding time in, and episodes of, hypoxaemia and hyperoxaemia. This algorithm performed better than one with a 30 s lockout, and considerably better than PD control., Conclusions: An enhanced PID algorithm was very effective for automated oxygen control in a simulation of oxygenation, and deserves clinical evaluation., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)

Background: Oxygen saturation (SpO2) targeting in the preterm infant may be improved with a better understanding of the SpO2 responses to changes in inspired oxygen (FiO2)., Objective: We investigated the first-order FiO2-SpO2 relationship, aiming to quantify the parameters governing that relationship, the influences on these parameters and their variability., Methods: In recordings of FiO2 and SpO2 from preterm infants on continuous positive airway pressure and supplemental oxygen, we identified unique FiO2 adjustments and mapped the subsequent SpO2 responses. For responses identified as first-order, the delay, time constant and gain parameters were determined. Clinical and physiological predictors of these parameters were sought in regression analysis, and intra- and inter-subject variability was evaluated., Results: In 3,788 h of available data from 47 infants at 31 (28-33) post-menstrual weeks [median (interquartile range)], we identified 993 unique FiO2 adjustments followed by a first-order SpO2 response. All response parameters differed between FiO2 increments and decrements, with increments having a shorter delay, longer time constant and higher gain [2.9 (1.7-4.8) vs. 1.3 (0.58-2.6), p < 0.05]. Gain was also higher in less mature infants and in the setting of recent SpO2 instability, and was diminished with increasing severity of lung dysfunction. Intra-subject variability in all parameters was prominent., Conclusions: First-order SpO2 responses show variable gain, influenced by the direction of FiO2 adjustment and the severity of lung disease, as well as substantial intra-subject parameter variability. These findings should be taken into account in adjustment of FiO2 for SpO2 targeting in preterm infants., (© 2015 S. Karger AG, Basel.)

Oxygen saturation (SpO2) signal dropout leaves caregivers without a reliable measure to guide oxygen therapy. We studied SpO2 dropout in preterm infants on continuous positive airway pressure, noting the SpO2 values at signal loss and recovery and thus the resultant change in SpO2, and the factors influencing this parameter. In 32 infants of median gestation 26 weeks, a total of 3932 SpO2 dropout episodes were identified (1.1 episodes/h). In the episodes overall, SpO2 decreased by 1.1%, with the SpO2 change influenced by starting SpO2 (negative correlation), but not dropout duration. For episodes starting in hypoxia (SpO2 <85%), SpO2 recovered at a median of 3.2% higher than at SpO2 dropout, with a downward trajectory in a quarter of cases. We conclude that after signal dropout SpO2 generally recovers in a relative normoxic range. Blind FiO2 adjustments are thus unlikely to be of benefit during most SpO2 dropout episodes., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)

In this paper an investigation of the gain, delay, and time-constant parameters of the transfer function describing the relation between fraction of inspired oxygen (FiO2) and oxygen saturation in the blood (SpO2) in preterm infants is presented. The parameters were estimated following FiO2 adjustments and goodness of fit was used to assess the validity of the model when using an assumed first-order transfer function. For responses identified to be first-order, the estimated parameters were then clustered to identify areas where they tended to be concentrated. Each group described an operating region of the transfer function; thus, predicting the right operating region could potentially assist a range-based robust inspired oxygen controller to provide more optimal control by adapting itself to different clusters. Accordingly, the samples were assigned labels based on their cluster associations and 14 features available at the time of each adjustment were used as inputs to an artificial neural network to classify the clustered samples. The validity study suggested that 37% of the adjustments were followed by first-order responses. Prediction studies on the first-order responses indicated that the clusters could be predicted with an average accuracy of 64% when the parameters were divided into two groups.

Objective: The precision of oxygen saturation (SpO2) targeting in preterm infants on continuous positive airway pressure (CPAP) is incompletely characterized. We therefore evaluated SpO2 targeting in infants solely receiving CPAP, aiming to describe their SpO2 profile, to document the frequency of prolonged hyperoxia and hypoxia episodes and of fraction of inspired oxygen (FiO2) adjustments, and to explore the relationships with neonatal intensive care unit operational factors., Study Design: Preterm infants <37 weeks' gestation in 2 neonatal intensive care units were studied if they were receiving CPAP and in supplemental oxygen at the beginning of each 24-hour recording. SpO2, heart rate, and FiO2 were recorded (sampling interval 1-2 seconds). We measured the proportion of time spent in predefined SpO2 ranges, the frequency of prolonged episodes (≥30 seconds) of SpO2 deviation, and the effect of operational factors including nurse-patient ratio., Results: A total of 4034 usable hours of data were recorded from 45 infants of gestation 30 (27-32) weeks (median [IQR]). When requiring supplemental oxygen, infants were in the target SpO2 range (88%-92%) for only 31% (19%-39%) of total recording time, with 48 (6.9-90) episodes per 24 hours of severe hyperoxia (SpO2 ≥98%), and 9.0 (1.6-21) episodes per 24 hours of hypoxia (SpO2 <80%). An increased frequency of prolonged hyperoxia in supplemental oxygen was noted when nurses were each caring for more patients. Adjustments to FiO2 were made 25 (16-41) times per day., Conclusion: SpO2 targeting is challenging in preterm infants receiving CPAP support, with a high proportion of time spent outside the target range and frequent prolonged hypoxic and hyperoxic episodes., (Copyright © 2014 Mosby, Inc. All rights reserved.)

The extended period many people now spend looking at computer screens is thought to affect eyesight over the long term. In this paper we are concerned with developing and initial evaluation of a wireless camera-based tracking system providing quantitative assessment of computer screen interaction. The system utilizes a stereo camera system and wireless XBee based infrared markers and enables unobtrusive monitoring. Preliminary results indicate that the system is an excellent method of monitoring eye-screen distance. This type of system will enable future studies of eye-screen distance for computer users.

A single camera stereographic imaging system was designed, built and tested for the intended application of tracking upper limb motion. The system consisted of a camera, quad-mirror system and image acquisition and processing software. This paper describes the design methods used and the testing of the system. Design methods included geometry optimisation and testing consisted of proof-of-concept trials. Preliminary results show that the concept is sound.

This paper describes the design of a medication dispenser developed for narcotic rehabilitation programs. The dispenser holds up to four doses of medication and operates under remote supervision. A direct-into-mouth dispensing mechanism is a feature of the device. The mechanical dispenser mechanism includes a rotating barrel, medication tubes and dispensing slider unit. The electronic design involves a microprocessor PIC18F4550, stepper-motors, sensing devices a LabVIEW-based computer interface for remote supervisory control and monitoring. The dispenser stores medication and successfully delivers it directly into the mouth under remote supervision.

Low bandwidth has long been a reason for the unsuitability of wireless internet in telemedicine. However with the advent of extended third generation wireless as an economically accessible high speed network, more opportunities are being created in this area of telemedicine. This paper explores the opportunity created by the latest wireless broadband technology for remote monitoring of patients in the home.

Catheter curvature affects accuracy of intra-ventricular blood volume measurement when using conductance catheter techniques, especially with irregular geometries, such as in the right ventricle. To investigate this effect, we present results from using different curved catheter configurations and different numbers of electrodes in a simple Finite Element model. It was found that there is an apparent increase in accuracy with curvature, due to greater linearity in the field in the region of the measurement electrodes, which are located farther from the source electrodes as curvature increases. Also, optimization using Genetic Algorithms is presented as a method to find the optimal distribution of measurement electrodes. We plan to extend these results to develop improved electrode configurations for using in blood volume measurement in the right ventricle.

Assessment of opioid dependent patients in a replacement program has traditionally relied on conventional methods such as urine testing or face to face examination with a physician. We are introducing new assessment techniques based on pupillometry, reaction time and slurring of speech. The pupillometry test uses a webcam, controlled lighting and customized software to measure pupil parameters. The reaction time test uses a push-button to detect time to respond to a visual stimulus. The slurred speech test involves detection of slurring of a set of individual test words. These three tests will be combined to provide the physician with an objective "sedation index" for patients. These techniques will be used with remote dispensing technology currently under development.

Physicians are often considered as the final pathway for nearly all professional decisions about the use of health resources. Yet with respect to drugs, pharmacists are in many cases the final link between the medication and the patient. This approach of medication intake can be hazardous to the patient. Several mechanical as well as automatic medication dispensers incorporating alarm and automatic opening and closing mechanisms have been developed in the past. Current automatic dispensers incorporate features such as alarms, dose missed indicators followed by the access to the next dose, and simultaneous access to medication of different types. We are developing medication dispensing methods suitable for use in remote dispensing for opioid dependent patients. These include remote patient monitoring, facial image processing, and background processing techniques for monitoring and assessing the patient.

Estimation of parallel conductance using the impedance electrode technique is usually done assuming isotropic conditions. This may not be the best solution since the myocardium is an anisotropic material. This paper exposes the effect of fiber orientation for volume measurement using a conductor model with asymmetrical source electrodes. Simulation results show calculated volumes between surrounding materials with and without myocardial fiber orientation included in the model. We plan to extend these study results to the real heart for developing conductance catheter techniques for use in blood volume measurements in the right ventricle.

Even though sailboarding is a popular sport with many thousands of participants worldwide the forces experienced whilst sailboarding on water have not been documented. Harness line force is one of the key forces acting when sailboarding. The aim of this paper is to outline a method for measuring this force and to document its magnitude when sailboarding in a range of wind strengths (12 knots to 30 knots) using two different sail sizes (6.5 m2 in lighter winds and 5.0 m2 in stronger ones). A sailboard harness spreader bar was instrumented with a force transducer, amplifier and datalogger, to enable measurement of harness line force while sailboarding. Using this instrumented spreader bar an expert sailboarder sailed in a figure of eight fashion around two buoys lying across the wind. Average harness force measured during each leg of the figure of eight course was 381.6 +/- 43.2 N when using the 5 m2 sail and 415.0 +/- 66.7 N when using the 6.5 m2 sail. The average gybing time was 9.9 +/- 2.0 seconds when using the 5 m2 sail and significantly higher (p = 0.035) 12.2 +/- 1.3 seconds when using the 6.5 m2 sail. The results from this paper indicate that downsizing sail area to cope with the increased wind strength maintains harness force within a manageable range. For the subject in question the average harness line force was approximately 4.9 N/kg body weight.

Purpose: The purpose of this study was to assess the performance of sealants placed by senior dental students as part of a comprehensive dental care program that included periodic patient recall., Methods: The dental records of 100 patients ranging in age from 6 to 13 years were selected for review to determine the treatments provided for first permanent molars over time. Criteria for inclusion were: 1) at least five documented recall examinations and 2) all four first permanent molars had to have been treated with an occlusal pit and fissure sealant. The data collected included: 1) the age of the patient at the time of initial sealant placement; 2) the subsequent treatment provided to the first permanent molars, including retreatment with sealant or restoration and the date the services were provided; 3) the last date of follow-up examination in the pediatric dental program., Results: A total of 400 molars were followed for an average of 54 months. Fifty-two percent of all molars received no further treatment after initial placement of sealant. Approximately 35% received retreatment with sealant only. The total number of molars receiving sealant material only was 343 (86%). The total number of teeth that were judged to require restoration was 57 (14%). No relationship was noted between the patient's age at placement of the occlusal sealant and sealant performance., Conclusion: In a dental school clinic, occlusal sealants were effective at preventing caries in a comprehensive care program that included periodic recall.