107 results on '"Gal-Or, O."'
Search Results
2. Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections
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Ben-David, D., Kordevani, R., Keller, N., Tal, I., Marzel, A., Gal-Mor, O., Maor, Y., and Rahav, G.
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- 2012
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3. P016 Colonoids derived from UC patients retain higher transcriptional response to inflammatory triggers in-vitro, even after several passages
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Abbas Egbariya, H, primary, Ben-Shoshan, M, additional, Braun, Z, additional, Berger, T, additional, Granot, M, additional, Loberman-Nachum, N, additional, Vais, B, additional, Gal Mor, O, additional, Amir, A, additional, and Haberman, Y, additional
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- 2022
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4. P009 Disease classifier and microbial dysbiosis index tools cross-predict various pathogenic conditions due to general microbial signal
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Abbas Egbariya, H, primary, Braun, T, additional, Hadar, R, additional, Gal-Mor, O, additional, Shental, N, additional, Haberman, Y, additional, and Amir, A, additional
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- 2021
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5. Starving affects cdx gene expression during small intestinal development in the chick
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Geyra, A., Uni, Z., Gal-Garber, O., Guy, D., and Sklan, D.
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Intestine, Small -- Growth ,Developmental biology -- Genetic aspects ,Gene expression -- Physiological aspects ,Food/cooking/nutrition - Abstract
The small intestine of the chicken undergoes intensive changes in the immediate posthatch period, increasing in size and developing crypts, villi and mature enterocytes. During this time, chicks are also transferring from nutrition based on the lipid-rich yolk to exogenous carbohydrate-rich feeds. The cdx homeobox genes participate in axial patterning and in definition of cell identity in embryos, and some cdx genes remain active postpartum in organs such as the intestine. In this study, the transcription patterns of two of these genes, cdxA and cdxB, were examined in the small intestine of the embryo and posthatch chick; in addition, the effects on these genes of starving for 48 h at hatch were examined. Both cdx transcription factors were upregulated toward the time of hatch and were observed in proliferating enterocytes; this enhanced expression continued posthatch. Distribution of cdxA changed with age and was found at higher concentrations in mature enterocytes. Starving from 0 to 48 h posthatch retarded growth and decreased enterocyte proliferation and expression of cdxA and cdxB. After access to feed, expression of cdx genes was enhanced. Chicken homeobox genes cdxA and cdxB are expressed in all enterocytes during embryonic and posthatch development; however, cdxA may have a role in enterocyte maturation posthatch. CdxB was expressed later in development then previously reported. J. Nutr. 132: 911-917, 2002. KEY WORDS: * cdx * chicks * intestine * development
- Published
- 2002
6. Choroidal and Sub-Retinal Pigment Epithelium Caverns Multimodal Imaging and Correspondence with Friedman Lipid Globules
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Dolz-Marco R, Glover JP, Gal-Or O, Litts KM, Messinger JD, Zhang Y, Cozzi M, Pellegrini M, Freund KB, Staurenghi G, and Curcio CA
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genetic structures ,sense organs ,eye diseases - Abstract
Purpose: To survey Friedman lipid globules by high-resolution histologic examination and to compare with multimodal imaging of hyporeflective caverns in eyes with geographic atrophy (GA) secondary to age-related macular (AMD) and other retinal diseases. Design: Histologic survey of donor eyes with and without AMD. Clinical case series with multimodal imaging analysis. Participants: Donor eyes (n = 139; 26 with early AMD, 13 with GA, 40 with nAMD, 52 with a healthy macula, and 8 with other or unknown characteristics) and 41 eyes of 28 participants with GA (n = 16), nAMD (n = 8), Stargardt disease (n = 4), cone dystrophy (n = 2), pachychoroid spectrum (n = 6), choroidal hemangioma (n = 1), and healthy eyes (n = 4). Methods: Donor eyes were prepared for macula-wide epoxy resin sections through the foveal and perifoveal area. In patients, caverns were identified as nonreflective spaces on OCT images. Multimodal imaging included color and red-free fundus photography; fundus autofluorescence; fluorescein and, indocyanine green angiography; OCT angiography; near-infrared reflectance; and confocal multispectral (MultiColor [Spectralis, Heidelberg Engineering, Germany]) imaging. Main Outcome Measures: Presence and morphologic features of globules, and presence and appearance of caverns on multimodal imaging. Results: Globules were found primarily in the inner choroidal stroma (91.0%), but also localized to the sclera (4.9%) and neovascular membranes (2.1%). Mean diameters of solitary and multilobular globules were 58.9 +/- 37.8 mu m and 65.4 +/- 27.9 mu m, respectively. Globules showed morphologic signs of dynamism including pitting, dispersion, disintegration, and crystal formation. Evidence for inflammation in the surrounding tissue was absent. En face OCT rendered sharply delimited hyporeflective areas as large as choroidal vessels, frequently grouped around choroid vessels or in the neovascular tissue. Cross-sectional OCT revealed a characteristic posterior hypertransmission. OCT angiography showed absence of flow signal within caverns. Conclusions: Based on prior literature documenting OCT signatures of tissue lipid in atheroma and nAMD, we speculate that caverns are lipid rich. Globules, with similar sizes and tissue locations in AMD and healthy persons, are candidates for histologic correlates of caverns. The role of globules in chorioretinal physiologic features, perhaps as a lipid depot for photoreceptor metabolism, is approachable through clinical imaging. (C) 2018 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology
- Published
- 2018
7. Psychological basics of college students' English language proficiency formation in professionally oriented writing
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Gal`chenko, O.
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college ,early youth ,psychological and age peculiarities ,English writing for specific purposes ,коледж ,рання юність ,психолого-вікові особливості ,професійно орієнтоване письмо - Abstract
У статті розглянуто вікові особливості студентів коледжів. Визначено психологічніпередумови формування англомовної компетентності в письмі в період “ранньої юності”. Висвітлено умови ефективного навчання англомовного професійно орієнтованого письма з урахуванням вікових особливостей юнаків та дівчат., The article deals with age peculiarities of college students. The psychological basics of English language proficiency formation in writing at the early youth age are defined. The conditions of successful teaching professionally oriented English writing with considering of mid-teens` age peculiarities are lightened.
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- 2016
8. Action Observation of Motor Skills Followed by Immediate Sleep Enhances the Motor Rehabilitation of Older Adults With Stroke
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Lubart, Alisa A., primary, Leibovitz, Arthur I., additional, Peleg, Liora D., additional, Yarovoy, Alexandra I., additional, Gal, Gilad O., additional, Mizrahi, Eliyahu H., additional, and Lubart, Emily N., additional
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- 2017
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9. Effect of photoperiod and heat stress in the third trimester of gestation on milk production and circulating hormones in dairy goats
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Mabjeesh, S.J., primary, Sabastian, C., additional, Gal-Garber, O., additional, and Shamay, A., additional
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- 2013
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10. The Effect of Heat Stress on Ovarian Function of Laying Hens
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Rozenboim, I., primary, Tako, E., additional, Gal-Garber, O., additional, Proudman, J.A., additional, and Uni, Z., additional
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- 2007
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11. Effect of Photoperiod in the Third Trimester of Gestation on Milk Production and Circulating Hormones in Dairy Goats
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Mabjeesh, S.J., primary, Gal-Garber, O., additional, and Shamay, A., additional
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- 2007
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12. Aminopeptidase N Gene Expression and Abundance in Caprine Mammary Gland is Influenced by Circulating Plasma Peptide
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Mabjeesh, S.J., primary, Gal-Garber, O., additional, Milgram, J., additional, Feuermann, Y., additional, Cohen-Zinder, M., additional, and Shamay, A., additional
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- 2005
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13. Morphological, molecular, and functional changes in the chicken small intestine of the late-term embryo
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Uni, Z, primary, Tako, E, additional, Gal-Garber, O, additional, and Sklan, D, additional
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- 2003
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14. Nutrient transport in the small intestine: Na+,K+-ATPase expression and activity in the small intestine of the chicken as influenced by dietary sodium
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Gal-Garber, O, primary, Mabjeesh, SJ, additional, Sklan, D, additional, and Uni, Z, additional
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- 2003
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15. Photoluminescence and structural properties of cadmium sulphide thin films grown by different techniques
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Aguilar-Hern ndez, J, primary, Contreras-Puente, G, additional, Morales-Acevedo, A, additional, Vigil-Gal n, O, additional, Cruz-Gandarilla, F, additional, Vidal-Larramendi, J, additional, Escamilla-Esquivel, A, additional, Hern ndez-Contreras, H, additional, Hesiquio-Gardu o, M, additional, Arias-Carbajal, A, additional, Chavarr a-Casta eda, M, additional, and Arriaga-Mej a, G, additional
- Published
- 2002
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16. Characterization of the passivation of CdS thin films grown by chemical bath deposition on InP
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Gal n, O Vigil, primary, Larramendi, J Vidal, additional, Riech, I, additional, Rodr guez, G G Pe a, additional, Iribarren, A, additional, Aguilar-Hern ndez, J, additional, and Contreras-Puente, G, additional
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- 2002
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17. Changes in Growth and Function of Chick Small Intestine Epithelium Due to Early Thermal Conditioning
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Uni, Z., primary, Gal-Garber, O., additional, Geyra, A., additional, Sklan, D., additional, and Yahav, S., additional
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- 2001
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18. Vitamin A deficiency interferes with proliferation and maturation of cells in the chicken small intestine
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Uni, Z., primary, Zaiger, G., additional, Gal-Garber, O., additional, Pines, M., additional, Rozenboim, I., additional, and Reifen, R., additional
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- 2000
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19. Chicken intestinal aminopeptidase: partial sequence of the gene, expression and activity
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Gal-Garber, O., primary and Uni, Z., additional
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- 2000
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20. Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration
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Reiner, O, primary, Albrecht, U, additional, Gordon, M, additional, Chianese, KA, additional, Wong, C, additional, Gal-Gerber, O, additional, Sapir, T, additional, Siracusa, LD, additional, Buchberg, AM, additional, and Caskey, CT, additional
- Published
- 1995
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21. Nutrient Transport in the Small Intestine: Na[sup +],K[sup +]-ATPase Expression and Activity in the Small Intestine of the Chicken as Influenced by Dietary Sodium.
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Gal-Garber, O., Mabjeesh, S.J., Sklan, D., and Uni, Z.
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- *
SODIUM in the body , *SMALL intestine , *CHICKENS - Abstract
Focuses on nutrient transport in the small intestine of chickens fed with different concentrations of sodium (Na). Maintenance of homeostasis within the enterocyte; Enhancement of RNA expression at low dietary Na; Determination of activity and expression of intestinal Na.
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- 2003
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22. Partial sequence and expression of the gene for and activity of the sodium glucose transporter in the small intestine of fed, starved and refed chickens.
- Author
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Gal-Garber, Orit, Mabjeesh, Sameer J., Gal-Garber, O, Mabjeesh, S J, Sklan, D, and Uni, Z
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MESSENGER RNA ,ANTISENSE DNA ,SODIUM cotransport systems ,CHICKENS ,GENETICS - Abstract
A 970 bp cDNA Na(+)/glucose cotransporter (SGLT1) was isolated and sequenced from chicken jejunum by reverse transcriptase polymerase chain reaction (RT-PCR) using primers based on conserved regions. Using the 970 bp PCR product as a specific probe, Northern Blot hybridization indicated a transcript of ca. 4 kb. The isolated chicken intestinal SGLT1 cDNA was used to quantitate mRNA expression. Glucose uptake activity and kinetics were determined in brush border membrane vesicles (BBMV) from jejunum tissue of chickens which were either fed, food-deprived or refed following food deprivation. Net glucose uptake to BBMV was higher (P: < 0.02) in the control and refed chicks (149 +/- 11.9, 139.6 +/- 7.43 pmol x mg protein(-1) x s(-1)) than in food-deprived chicks (107 +/- 4.23 pmol x mg protein(-1) x s(-1)). The k(m) (150 micromol/L) and V:max (1111.1 pmol x mg protein(-1) x s(-1)) were higher in the food-deprived chicks compared to control and refed birds (25, 24 micromol/L and 227,142 pmol x mg protein(-1) x s(-1), respectively). Expression of SGLT1 mRNA was significantly enhanced in the food-deprived and refed birds. In food-deprived chicks the lower affinity and higher activity of the SGLT1 transporter for glucose were accompanied by higher expression of mRNA which might indicate that the transporter was upregulated by low substrate concentration. Quantification of expression of intestinal mRNA of SGLT1 provides important information concerning control of nutrient uptake. [ABSTRACT FROM AUTHOR]
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- 2000
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23. Gene organization in the trxA/B-oriC region of the Streptomyces coelicolor chromosome and comparison with other eubacteria
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Gal-Mor, O., Borovok, I., Av-Gay, Y., Cohen, G., and Aharonowitz, Y.
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- 1998
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24. Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration
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Reiner, O., Albrecht, U., Gordon, M., Chianese, K. A., Wong, C., Gal-Gerber, O., Sapir, T., Siracusa, L. D., Arthur Buchberg, Caskey, C. T., and Eichele, G.
- Abstract
Miller-Dieker lissencephaly syndrome (MDS) is a human developmental brain malformation caused by neuronal migration defects resulting in abnormal layering of the cerebral cortex. LIS1, the gene defective in MDS, encodes a subunit of brain platelet-activating factor (PAF) acetylhydrolase which inactivates PAF, a neuroregulatory molecule. We have isolated murine cDNAs homologous to human LIS1 and mapped these to three different chromosomal loci (Lis1, Lis3, Lis4). The predicted sequences of murine Lis1 protein and its human homolog LIS1 are virtually identical. In the developing mouse and human, Lis1 and LIS1 genes were strongly expressed in the cortical plate. In the adult mouse Lis1 transcripts were abundant in cortex and hippocampus. The direct correlation between cortical defects in MDS patients and Lis1 expression in the murine cortex suggest that the mouse is a model system suitable to study the mechanistic basis of this intriguing genetic disease.
25. Effect of tumor inhibitory and stimulatory doses of levan, alone and in combination with cyclophosphamide, on spleen and lymph nodes
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Leibovici, J., primary, Kopel, S., additional, Siegal, A., additional, and Gal-Mor, O., additional
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- 1986
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26. Reduced choriocapillaris flow in eyes with type 3 neovascularization and age-related macular degeneration
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Riccardo Sacconi, K. Bailey Freund, David Sarraf, Eric H. Souied, Giuseppe Querques, Alexandra Miere, Orly Gal-Or, Srinivas R. Sadda, Enrico Borrelli, Borrelli, E., Souied, E. H., Bailey Freund, K., Querques, G., Miere, A., Gal-Or, O., Sacconi, R., Sadda, S. R., and Sarraf, D.
- Subjects
Male ,0301 basic medicine ,genetic structures ,optical coherence tomography angiography ,Neovascularization ,Macular Degeneration ,0302 clinical medicine ,Retrospective Studie ,Medicine ,Fluorescein Angiography ,Aged, 80 and over ,medicine.diagnostic_test ,General Medicine ,Middle Aged ,Fluorescein angiography ,choriocapillaris flow ,Female ,medicine.symptom ,type 3 neovascularization ,Tomography, Optical Coherence ,Human ,medicine.medical_specialty ,03 medical and health sciences ,Ophthalmology ,Age related ,Type 3 neovascularization ,Humans ,age-related macular degeneration ,Aged ,Retrospective Studies ,Choroid ,business.industry ,Age-related macular degeneration ,Retrospective cohort study ,Optical coherence tomography angiography ,Macular degeneration ,medicine.disease ,Choroidal Neovascularization ,eye diseases ,Capillaries ,Choriocapillari ,Capillarie ,030104 developmental biology ,Multicenter study ,030221 ophthalmology & optometry ,sense organs ,business - Abstract
Purpose: To study choriocapillaris (CC) flow in eyes with Type 3 neovascularization (NV) and age-related macular degeneration, using optical coherence tomography angiography analysis. Methods: In this multicenter, retrospective, observational study, we collected data from 21 patients with unilateral Type 3 NV and age-related macular degeneration, based on clinical examination, structural optical coherence tomography, and fluorescein angiography when available. An additional group of 20 nonneovascular age-related macular degeneration eyes with unilateral Type 1 or Type 2 NV due to age-related macular degeneration was included for comparison. En face optical coherence tomography angiography imaging (3 · 3 mm scans) with quantitative microvascular analysis of the CC was performed. Main outcome measures were: 1) the percent nonperfused choriocapillaris area; and 2) the average CC signal void size. Results: We included 21 patients with unilateral Type 3 NV (15 female, 71.5%) and 20 patients with unilateral Type 1 or 2 NV (9 female, 45.0% P = 0.118). Mean ± SD age was 82.1 ± 7.4 years in the unilateral Type 3 patients and 78.3 ± 8.1 in unilateral Type 1/2 NV subjects (P = 0.392). The percent nonperfused choriocapillaris area was 56.3 ± 8.1% in eyes with Type 3 NV and 51.9 ± 4.3% in the fellow eyes (P = 0.016). The average signal void size was also increased in those eyes with Type 3 NV (939.9 ± 680.9 mm 2 ), compared with the fellow eyes (616.3 ± 304.2 mm 2 , P = 0.039). The number of signal voids was reduced in the Type 3 NV eyes (604.5 ± 282.9 vs. 747.3 ± 195.8, P = 0.046). The subfoveal choroidal thickness was 135.9 ± 54.2 mm in eyes with Type 3 NV and 167.2 ± 65.4 mm in the fellow eyes (P = 0.003). In addition, the fellow eyes of patients with unilateral Type 3 NV displayed more significant CC flow abnormalities versus the fellow eyes with unilateral Type 1/2 NV (percent nonperfused choriocapillaris area = 51.9 ± 4.3% vs. 46.0 ± 2.1%, respectively, P, 0.0001; and average signal void size 616.3 ± 304.2 mm 2 versus 351.4 ± 65.5 mm 2 , respectively, P, 0.0001; and number of signal voids 747.3 ± 195.8 vs. 998.5 ± 147.3, respectively, P, 0.0001). Conclusion: Eyes with unilateral Type 3 NV illustrated increased CC nonperfusion versus fellow nonneovascular eyes. These results suggest that choroidal ischemia may play an important role in the development of Type 3 NV.
- Published
- 2018
27. Concurrent ciliary body detachment in patients presenting with serous choroidal detachment following glaucoma surgery.
- Author
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Barayev E, Gal-Or O, Gershoni A, Hadayer A, Barash D, Bahar I, Geffen N, and Zahavi A
- Subjects
- Humans, Male, Female, Aged, Prospective Studies, Middle Aged, Aged, 80 and over, Postoperative Complications diagnosis, Microscopy, Acoustic, Follow-Up Studies, Trabeculectomy adverse effects, Trabeculectomy methods, Glaucoma Drainage Implants adverse effects, Visual Acuity, Uveal Diseases diagnosis, Uveal Diseases etiology, Tomography, Optical Coherence methods, Ciliary Body, Intraocular Pressure physiology, Choroidal Effusions diagnosis, Choroidal Effusions etiology, Glaucoma surgery, Glaucoma physiopathology, Glaucoma complications
- Abstract
Purpose: To examine the rate of ciliary body detachment in patients with choroidal detachment following glaucoma surgery and its effect on the clinical course, management, and prognosis., Methods: A prospective observational case-series study. Patients with choroidal detachment following glaucoma surgery in 2018-2019 were included. All underwent complete ophthalmological examination and ultrasound biomicroscopy for evaluation of the presence and extent of ciliary body detachment. Follow-up examinations including ultrasound biomicroscopy scans were performed at 1 week, 1 month, 3 months, and 6 months., Results: Eight patients (8 eyes) were enrolled, 4 male and 4 female, of mean age 72 years (range 60-83). Five patients underwent trabeculectomy with mitomycin C (0.02%), which was combined with phacoemulsification cataract extraction in one; two underwent Ahmed glaucoma valve implantations, and one underwent ab-interno Xen45 gel stent implantation with mitomycin C (0.02%). The mean intraocular pressure was 26.0 ± 7.65 mmHg preoperatively, dropping to 6.9 ± 2.64 mmHg on first postoperative day one. Mean time from surgery to diagnosis of choroidal detachment was 11.6 ± 5.73 days. Ciliary body detachment was identified by ultrasound biomicroscopy in all patients, ranging between one and four quadrants. All patients were treated with topical steroids and cycloplegics; three (37.5%) received oral steroids. No surgical intervention for the choroidal or ciliary body detachments was indicated., Conclusions: In this real-world prospective study, concurrent ciliary body detachment was identified in all patients who presented with choroidal detachment following glaucoma surgery. This observation may deepen our understanding of the mechanism underlying the hypotony that is often seen after glaucoma surgery., (© 2024. The Author(s).)
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- 2024
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28. Prognostic factors for visual acuity improvement after treatment of submacular hemorrhage secondary to exudative age-related macular degeneration.
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Barayev E, Tiosano A, Zlatkin R, Elul R, Dotan A, Hadayer A, Gal-Or O, and Ehrlich R
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- Humans, Retrospective Studies, Male, Female, Aged, 80 and over, Prognosis, Fibrinolytic Agents therapeutic use, Fibrinolytic Agents administration & dosage, Fluorescein Angiography, Aged, Endotamponade, Follow-Up Studies, Visual Acuity physiology, Tomography, Optical Coherence, Retinal Hemorrhage etiology, Retinal Hemorrhage diagnosis, Retinal Hemorrhage therapy, Retinal Hemorrhage physiopathology, Wet Macular Degeneration diagnosis, Wet Macular Degeneration complications, Wet Macular Degeneration physiopathology, Wet Macular Degeneration drug therapy, Vitrectomy, Tissue Plasminogen Activator administration & dosage, Tissue Plasminogen Activator therapeutic use, Intravitreal Injections
- Abstract
Purpose: To recognize prognostic factors for better final visual acuity (VA) in patients presenting with submacular hemorrhage (SMH) secondary to exudative age-related macular degeneration ., Methods: This retrospective study included patients who presented to a tertiary ophthalmology department between 2012 and 2019 with SMH and were treated by pars plana vitrectomy (PPV) or injection of tissue plasminogen activator (tPA) with pneumatic displacement. Baseline characteristics included demographic data, VA and optical coherence tomography (OCT) characteristics of the SMH. Patients were divided into groups by improvement of at least 2 lines in BCVA (best corrected visual acuity), and by having a final BCVA better than 20/200., Results: Forty-three eyes of 43 patients were included. Mean age was 86.72 ± 7.18. Prognostic factors for final VA better than 20/200 included better VA at presentation (1.25 vs 1.90 logMAR, p < 0.001), smaller area of SMH in the infra-red image (19.47 mm
2 vs 38.45 mm2 , p = 0.024), and lower height of SMH as measured by OCT (713.5 µm vs 962.5 µm, p = 0.03). Third of the patients improved in ≥2 lines from presentation, all in the group of the pneumatic and TPA displacement., Conclusion: Smaller SMHs with good VA at presentation have a better chance for improvement and result in a better final VA. These patients may benefit the most from pneumatic displacement of the SMH with intravitreal tPA and gas., Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.- Published
- 2024
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29. Peripapillary retinal nerve fiber layer thickness as a diagnostic tool for pseudophakic cystoid macular edema.
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Rabina G, Shtayer C, Shemesh R, Mimouni M, Gal-Or O, Nemet AY, Geffen N, and Segal O
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- Humans, Male, Middle Aged, Aged, Retrospective Studies, Retina, Tomography, Optical Coherence methods, Nerve Fibers, Macular Edema diagnosis, Macular Edema etiology
- Abstract
Purpose: To investigate the effects of pseudophakic cystoid macular edema (PCME) on retinal nerve fiber layer (RNFL) thickness before and after treatment using optical coherence tomography (OCT)., Methods: A retrospective, observational study of consecutive patients diagnosed with PCME after cataract surgery. Patients underwent macular and RNFL OCT imaging at time of diagnosis and during follow up. OCT was performed for both the study eye and the contralateral healthy eye which served as control. All patients were followed for a period of at least 6 months., Results: Overall, 40 eyes of 40 patients with a mean age of 71.1 ± 8.1 years of which 45% (n = 18) were of male gender were included in this study. At presentation, the central thickness in the PCME eye was significantly higher than in the contralateral eye (515.7 ± 127.9μm versus 238.1 ± 41.8μm, p < 0.001). Similarly, all macular measurements were significantly higher in the PCME eye compared to the contralateral eye (p < 0.001 for all). In terms of RNFL measurements, the PCME eyes had greater global (p < 0.001), superonasal (p = 0.001) and superotemporal (p = 0.005) thickness values. PCME eyes demonstrated a significant decrease in thickness for all macular and RNFL parameters following resolution of CME (p < 0.05 for all)., Conclusions: PCME patients presents with greater global, superotemporal and superonasal RNFL thickness in comparison to the other healthy eye. After resolution of PCME, there is significant thinning of RNFL. Peripapillary RNFL thickness may serve as an additional parameter for diagnosis and follow-up of PCME., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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30. Artificial Intelligence in Ophthalmology: Present and Future Directions.
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Gal-Or O, Tiosano A, Perchik I, Giladi Y, and Bahar I
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- Humans, Forecasting, Artificial Intelligence, Ophthalmology
- Published
- 2024
31. Anatomical and Functional Outcomes with Prompt versus Delayed Initiation of Anti-VEGF in Exudative Age-Related Macular Degeneration.
- Author
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Gershoni A, Barayev E, Daood RH, Yogev M, Gal-Or O, Reitblat O, Tsessler M, Schaap Fogler M, Tuuminen R, and Ehrlich R
- Abstract
Purpose: To investigate the correlation between time from diagnosis of treatment-naïve exudative age-related macular degeneration (AMD) to the introduction of anti-VEGF treatment and anatomical and functional outcomes., Design: Retrospective cohort study., Methods: Included were treatment-naïve exudative AMD patients who presented to a single tertiary medical center between 2012 and 2018. All patients were treated within the first 30 days of their diagnosis with three monthly intravitreal injections of bevacizumab. Patients were divided into three groups: group 1 (prompt anti-VEGF) were injected with bevacizumab within ten days, group 2 (intermediate anti-VEGF) within 11-20 days, and group 3 (delayed anti-VEGF) within 21-30 days from diagnosis. Baseline characteristics and clinical outcomes were compared up to two years from treatment., Results: 146 eyes of 146 patients were included. Sixty-eight patients were in the prompt anti-VEGF group, 31 in the intermediate anti-VEGF group, and 47 in the delayed anti-VEGF group. Following the induction phase of three intravitreal bevacizumab injections, the mean central subfield macular thickness (328.0 ± 115.4 µm vs. 364.6 ± 127.2 µm vs. 337.7 ± 150.1 µm, p = 0.432) and the best-corrected visual acuity (0.47 ± 0.38 vs. 0.59 ± 0.48 vs. 0.47 ± 0.44 logMAR units, p = 0.458) were comparable between the prompt, intermediate and delayed anti-VEGF groups. Anatomical and functional outcomes, treatment burden, number of relapses and eyes with second-line anti-VEGF therapy were comparable between the groups at both 1-year and 2-year timepoints., Conclusions: Our real-world evidence data emphasize that even if anti-VEGF induction cannot be initiated promptly within ten days from diagnosis of naïve exudative AMD, the visual and anatomical prognosis of the patients may not worsen if the treatment is started within one month of diagnosis.
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- 2023
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32. Optical Coherence Tomography Angiography for the Differentiation of Glaucoma from Pituitary Macroadenoma Related Optic Disc Measurements.
- Author
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Zahavi A, Weinberger Y, Geffen N, Gabbay I, Mimouni M, Gal-Or O, Stiebel-Kalish H, and Gaton DD
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- Humans, Male, Female, Middle Aged, Aged, Aged, 80 and over, Tomography, Optical Coherence methods, Case-Control Studies, Retinal Ganglion Cells, Angiography, Intraocular Pressure, Optic Disk, Glaucoma diagnosis, Pituitary Neoplasms diagnostic imaging
- Abstract
Objective: To determine the potential of optical coherence tomography (OCT) and OCT angiography (OCTA) to distinguish between glaucoma and pituitary macroadenoma by optic disc appearance., Methods: This prospective case-control study comprised 31 patients: 23 with glaucoma (18 male, 5 female) and 8 with pituitary macroadenoma and chiasmatic compression (3 male, 5 female). The corresponding mean ages were 72.8 years (range 58-90) and 60.7 years (range 43-73). All participants underwent complete ophthalmological examination, spectral domain OCT and OCTA, and visual field testing. Clinical, imaging, and visual field results were compared between the groups., Results: On OCT analysis, the glaucoma group had relatively lower peripapillary retinal nerve fiber layer (RNFL) thickness (65.79 ± 15.46, 86.0 ± 11.37, respectively, P = .002) and lower rim area (1.00 ± 0.22 mm
2 and 1.2 ± 0.15 mm2 , respectively, P = .005). On OCTA, peripapillary vessel density was significantly lower in all quadrants in the glaucoma group. The significance of these between-group differences was maintained when patients were stratified by visual field mean deviation., Conclusions: This is the first comparative analysis of optic disc morphology between glaucoma and pituitary macroadenoma using combined OCT and OCTA. The results yielded lower peripapillary RNFL thickness, lower rim area, and lower peripapillary vessel density in the glaucoma group. These parameters may aid in the initial differentiation between these two optic neuropathies.- Published
- 2023
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33. Outcomes of Combined Phacovitrectomy Without Corneal Suturing.
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Hadayer A, Weinberger Y, Corina Sela T, Gal-Or O, Weinberger D, and Ehrlich R
- Subjects
- Humans, Retrospective Studies, Cornea surgery, Sutures, Neurosurgical Procedures, Cataract
- Abstract
Background: During combined phacovitrectomy, it is common practice to suture the main corneal incision to prevent intraoperative and postoperative wound leak. However, it may be possible to avoid suturing using a self-sealing corneal incision technique as in standard cataract surgery., Objectives: To evaluate the clinical outcome, safety, and complications of combined phacovitrectomy without preventive suturing., Methods: This retrospective case series study included consecutive patients who underwent combined phacovitrectomy between January 2018 and June 2019 for mixed indications. Surgeries were performed at a tertiary university hospital. All surgeries were performed by the same two retinal surgeons. Cataract surgery was performed first, followed by insertion of trocars and vitrectomy. Corneal sutures were not planned but were used at the discretion of the surgeon., Results: The cohort included 106 eyes of 102 patients. Suturing of the main corneal incision was deemed necessary in five cases (5%) because of a main incision leak or anterior chamber shallowing during trocar insertion. No other complications related to the absence of prophylactic corneal sutures were encountered during surgery or follow-up., Conclusions: Preventive corneal suturing may not be necessary in combined phacovitrectomy surgery and can be used in the few cases in which it is indicated during surgery.
- Published
- 2023
34. THE CHRYSANTHEMUM PHENOTYPE OF IDIOPATHIC MULTIFOCAL CHOROIDITIS.
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Ramtohul P, Cicinelli MV, Dolz-Marco R, Gal-Or O, Mrejen S, García-Martínez JR, Goldberg A, Cunha de Souza E, Miserocchi E, Cunningham ET Jr, Yannuzzi LA, Freund KB, and Tsui E
- Subjects
- Humans, Multifocal Choroiditis, Retrospective Studies, Fundus Oculi, Choroid pathology, Fluorescein Angiography methods, Tomography, Optical Coherence methods, Choroiditis diagnosis
- Abstract
Purpose: To describe the clinical characteristics and multimodal imaging features of a distinctive subtype of active idiopathic multifocal choroiditis (iMFC) lesions with grey-yellow chorioretinal lesions surrounded by smaller satellite dots, a presentation referred to as "chrysanthemum lesions.", Methods: Retrospective, observational, multicenter case series of eyes with active iMFC and chrysanthemum lesions. Multimodal imaging features were reviewed and presented., Results: Twenty-five eyes from 20 patients (12 women and 8 men), with a mean age of 35.8 ± 17.0 years (range, 7-78 years) were included. Chrysanthemum lesions were equally located in the macula (48.0%) or the mid/far periphery (52.0%). The number of lesions per eye varied from 1 (16.0%) to more than 20 (56.0%). On optical coherence tomography, chrysanthemum lesions showed typical features of iMFC, including subretinal hyperreflective material splitting the retinal pigment epithelium/Bruch membrane. Chrysanthemum lesions were hypoautofluorescent on fundus autofluorescence imaging, hyperfluorescent on fluorescein angiography, hypofluorescent on indocyanine green angiography, and associated with choriocapillaris flow signal deficit on optical coherence tomography angiography., Conclusion: Active iMFC may present with findings resembling chrysanthemum lesions. The distinctive lesion morphology on ophthalmoscopic examination, the large number of lesions, and the high prevalence of exclusive midperipheral and far peripheral involvement may represent a distinctive phenotype of iMFC.
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- 2023
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35. Optical coherence tomography angiography patterns of type 1 macular neovascularization in age-related macular degeneration patients.
- Author
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Barayev E, Meshi A, Gershoni A, Segal O, Dotan A, Hadayer A, Schaap Fogler M, Ehrlich R, and Gal-Or O
- Subjects
- Humans, Tomography, Optical Coherence methods, Fluorescein Angiography methods, Cross-Sectional Studies, Fundus Oculi, Retrospective Studies, Angiogenesis Inhibitors therapeutic use, Choroidal Neovascularization diagnosis, Choroidal Neovascularization drug therapy, Macular Degeneration diagnosis, Macular Degeneration drug therapy, Wet Macular Degeneration diagnosis, Wet Macular Degeneration drug therapy
- Abstract
Purpose: To compare morphologic characteristics of type 1 macular neovascularization (MNV) flow pattern in treatment-naïve and previously treated patients with age-related macular degeneration (AMD) as assessed by optical coherence tomography angiography (OCTA)., Study Design: Cross-sectional study., Materials and Methods: Macular OCT angiography images were acquired using RTVue XR Avanti with AngioVue. Distinct morphologic biomarkers and quantifiable features of the neovascular membranes were studied on en-face projection images comparing treatment-naïve and previously treated patients., Results: The study included 68 eyes of 58 patients. Among them, 24 eyes were treatment-naïve, and the remaining eyes had received a mean of 19.6 injections. Immature lesions were more associated with treatment-naïve eyes and hyper-mature lesions were associated with previously treated eyes (p = 0.005). Tangle pattern was associated with treatment-naïve eyes (p = 0.013), whereas mature core vessels and sea fan pattern were associated more with previously treated eyes (p = 0.001 and p = 0.044, respectively). Vascular density of the neovascular membrane was higher in the treatment-naïve group (p = 0.036) and the average MNV area was similar between the 2 groups (p = 0.683)., Conclusions: Based on OCTA, morphologic biomarkers of type 1 MNV might be an indication of previous treatment. The MNV pattern can improve our understanding of its maturation under anti-VEGF treatment and might be valuable to better guide therapeutic decisions and provide more personalized care to patients with AMD.
- Published
- 2023
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36. Incidental Unilateral Macular Lesions in Children.
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Ehrenberg M, Gal Or O, Friling R, Pesoa Y, Dotan G, and Sternfeld A
- Subjects
- Female, Humans, Child, Child, Preschool, Male, Retrospective Studies, Tomography, Optical Coherence methods, Retinal Pigment Epithelium pathology, Fluorescein Angiography methods, Retinal Diseases diagnosis, Retinal Diseases pathology, Macular Degeneration pathology
- Abstract
Background: This study aims to examine the rare entity of unilateral macular lesions in the pediatric population and describe the distinct diagnoses and characterizations related to these findings., Methods: A retrospective cohort design. The database of the ophthalmology clinic in a tertiary medical center was reviewed to identify all children with incidental unilateral macular findings, examined during 2016 through 2021., Results: Twenty children were included. Mean age was 7.8 ± 3.4 years, 50% were girls. The most common macular lesion was torpedo maculopathy (50%), followed by pigmentary changes (25%), discoid maculopathy (15%), macular scar and combined hamartoma of the retina and retinal pigment epithelium (RPE) (5% each). None of the lesions changed after a mean follow-up duration of 2.3 ± 1.5 years. Visual acuity in the involved eye was equal to that in the contralateral eye in 90% of patients and did not change from initial to final visit., Conclusion: Incidental unilateral macular lesions in the pediatric population are usually benign, stable, and do not affect vision. Long-term follow-up is advised, as vision-threatening alterations may appear. [ Ophthalmic Surg Lasers Imaging Retina 2023;54:346-352.] .
- Published
- 2023
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37. LASER PHOTOCOAGULATION FOR THE TREATMENT OF OPTIC NERVE HEAD PIT-RELATED MACULOPATHY IN A PATIENT WITH BILATERAL CHORIORETINAL COLOBOMA.
- Author
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Weinberger Y, Weinberger D, Priel E, Gal-Or O, and Ehrlich R
- Subjects
- Female, Humans, Adolescent, Light Coagulation, Tomography, Optical Coherence methods, Lasers, Optic Disk, Coloboma diagnosis, Retinal Diseases diagnosis, Macular Degeneration complications
- Abstract
Purpose: To report a case of laser photocoagulation for the treatment of a combined coloboma and optic nerve head pit-related maculopathy in a patient with bilateral chorioretinal coloboma., Methods: A case report., Results: A 15-year-old woman, presented with the visual acuity of 20/100 in her right eye for six weeks. She was diagnosed with macular detachment secondary to optic nerve head pit in her right eye and bilateral chorioretinal coloboma. Multimodal imaging, including color photography, fluorescein angiography, and spectral-domain optical coherence tomography, was used to identify and demonstrate the location of the tract of fluid from the optic nerve head pit, isolated from the coloboma. Optical coherence tomography-guided laser photocoagulation treatment at the location of the tract resulted in complete resolution of macular fluid with visual recovery to 20/25., Conclusion: Our case stresses the value of correct diagnosis directing photocoagulation treatment of combined optic nerve head pit-related maculopathy in eyes with chorioretinal coloboma using multimodal imaging.
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- 2023
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38. Intravitreal Tissue Plasminogen Activator Injection for the Treatment of Proliferative Vitreoretinopathy in a Rabbit Model.
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Reitblat O, Barayev E, Gal-Or O, Tsessler M, and Dotan A
- Subjects
- Animals, Rabbits, Tissue Plasminogen Activator, Retina pathology, Intravitreal Injections, Vitreous Body, Disease Models, Animal, Vitreoretinopathy, Proliferative drug therapy
- Abstract
Introduction: The purpose of this study was to evaluate the effect of intravitreal injection of tissue plasminogen activator (tPA) on proliferative vitreoretinopathy (PVR)., Methods: PVR was induced in a rabbit model by intraocular injection of dispase (0.05 U/0.1 mL). Progression of PVR was followed by indirect ophthalmic examination. Following 6 weeks, 5 animals received intravitreal injection of 25 µg/0.1 mL tPA and four were injected with balanced salt solution (BSS). Animals were euthanized at 48 h following tPA/BSS injection, and eyes were enucleated for histological evaluation and staining with α-smooth muscle actin (αSMA) and Sirius Red., Results: Following tPA injection, one eye had a reduction in PVR from grade 2 to 1 and three eyes remained stable. Following BSS, PVR grade was unchanged in three eyes. In one eye in each group, the severity of PVR could not be assessed due to limited view. Staining with αSMA showed reduced presence of fibroblasts in eyes injected with tPA compared with those injected with BSS. Collagen type I and III, demonstrated by Sirius Red staining, was reduced in the tPA group in comparison with controls., Conclusion: Our results suggest that intravitreally injected tPA may show an inhibitory effect on PVR progression. Further exploration in clinical trials is desired., (© 2022 The Author(s). Published by S. Karger AG, Basel.)
- Published
- 2023
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39. Visual acuity outcome in patients with subretinal hemorrhage - office procedure vs. surgical treatment.
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Tiosano A, Gal-Or O, Fradkin M, Elul R, Dotan A, Hadayer A, Brody J, and Ehrlich R
- Subjects
- Humans, Retrospective Studies, Treatment Outcome, Retinal Hemorrhage diagnosis, Retinal Hemorrhage etiology, Retinal Hemorrhage surgery, Vitrectomy methods, Intravitreal Injections, Visual Acuity, Tissue Plasminogen Activator therapeutic use, Fibrinolytic Agents therapeutic use
- Abstract
Purpose: To evaluate the effects of intravitreal injection of tissue plasminogen activator (tPA) and gas vs. pars plana vitrectomy (PPV) surgery as first-line treatment for subretinal hemorrhage., Methods: Retrospective study of 107 adults treated for subretinal hemorrhage at a tertiary hospital during 2008-2019; 51 received injection of tPA and gas and 56 underwent PPV., Results: No between-group differences were found in age and sex, medical history, use of anticoagulants or antiplatelets, history of ocular surgeries, and previous use of intravitreal anti-VEGF. Overall follow-up time was longer in the PPV group (median 4.9 vs 3.28 years, p = 0.005). The hemorrhage was displaced in a similar percentage of patients in the tPA-and-gas group (n = 40, 78.4%) and the PPV group (n = 45, 80.4%) (p = 0.816). Approximately 80% of patients in the tPA-and-gas group were able to forgo PPV surgery. Visual acuity (in LogMAR) was similar in the two groups prior to the diagnosis of subretinal hemorrhage but better in the tPA-and-gas group at the end of follow-up (p < 0.001)., Conclusion: Injection of gas and tPA can be done immediately following diagnosis of subretinal hemorrhage as an office procedure. Visual acuity outcome is good, with a high rate of blood displacement. About 20% of patients might require additional PPV as secondary intervention.
- Published
- 2023
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40. Limbal-conjunctival autograft healing process-early postoperative OCT angiography study.
- Author
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Keshet Y, Polat A, Gal-Or O, Ben Ishai M, Keshet Y, Fradkin M, Schaap Fogler M, and Megiddo Barnir E
- Subjects
- Humans, Autografts, Tomography, Optical Coherence methods, Conjunctiva transplantation, Fluorescein Angiography methods, Transplantation, Autologous, Postoperative Period, Follow-Up Studies, Pterygium surgery
- Abstract
Purpose: To assess the normal healing process of limbal-conjunctival autograft (LCA) after pterygium removal during the early postoperative period using anterior segment optical coherence tomography angiography (OCTA)., Methods: Prospective case series of seven patients undergoing pterygium removal with LCA transplantation procedure, imaged with anterior segment OCTA, and anterior segment colour photos prior to the procedure and on postoperative day (POD) 1, 3, 7 and 30. Revascularization of the graft was analysed quantitatively and qualitatively to estimate patterns of blood vessel growth. Association between revascularization to graft thickness was also investigated., Results: On POD 1, all autografts showed either minimal flow signal or no signal at all (Mean 7.1 ± 3.3%). Regrowth of blood vessels into the graft was detected on OCTA scans on POD3 (8.7 ± 3.6%) to 7 (14.3 ± 4.1%), as nonorganised vessels formation in their appearance. Blood vessels were seen growing in a centrifugal pattern towards the surrounding conjunctiva, originating from the underlying episcleral vessels. Revascularization flow signal was seen throughout nearly all graft extent on day 30 (21.6 ± 2.2%). Graft oedema was evident on the first week (Mean 611 ± 120 μm, 695 ± 84 μm, 639 ± 96 μm of POD 1, 3 and 7, respectively), reducing substantially by day 30 (300 ± 108 μm)., Conclusions: OCTA imaging can be used to assess the LCA healing process during the early postoperative period. Revascularization occurring as early as 3-7 days post-surgery, seems to originate from the underlying episcleral vessels. Therefore, careful handling of the bare scleral surface during surgery may be prudent for achieving an adequate healing process., (© 2021. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.)
- Published
- 2022
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41. Postoperative complications of combined phacoemulsification and pars plana vitrectomy in diabetic retinopathy patients.
- Author
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Gershoni A, Barayev E, Jbara D, Hadayer A, Axer-Siegel R, Dotan A, Gal-Or O, Tuuminen R, and Ehrlich R
- Abstract
Purpose: To compare intra- and postoperative complications in combined phacoemulsification and pars plana vitrectomy surgeries performed in patients with non-proliferative diabetic retinopathy (NPDR) vs. proliferative diabetic retinopathy (PDR)., Methods: Retrospective, case series of patients with diabetic retinopathy who underwent combined phacovitrectomy surgery between 2008 and 2017. We compared intraoperative complications including posterior capsular rupture and retinal tear, and postoperative complications including corneal edema, macular edema (ME), epiretinal membrane (ERM), neovascular glaucoma and persistent inflammation., Results: A total of 104 eyes of 104 patients were included in this study. Twenty-four eyes (23.1%) were categorized as NPDR and 80 eyes (76.9%) as PDR. The most common indications for surgery in the NPDR group were ERM (67%) and rhegmatogenous retinal detachment (12.5%), while in the PDR group, indications were vitreous hemorrhage (56%) and tractional retinal detachment (19%). The most common intraoperative complication was retinal tear (8% in NPDR and 19% in PDR, p = 0.195) and postoperative complication was ME (29% in NPDR and 26% in PDR, p = 0.778). There were no statistically significant differences in intra- and postoperative complication rates between the NPDR and PDR groups, even after adjusting for confounders; patient age at surgery and indication for surgery., Conclusion: After combined phacovitrectomy in NPDR and PDR patients, new-onset ME was found in about a quarter of eyes in both groups. Intraoperative anti-VEGF or steroid administration, and intense postoperative anti-inflammatory medication and follow-up should be regarded after phacovitrectomy regardless of the DR level., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Gershoni, Barayev, Jbara, Hadayer, Axer-Siegel, Dotan, Gal-Or, Tuuminen and Ehrlich.)
- Published
- 2022
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42. Reply.
- Author
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Nahum Y, Gal-Or O, Dadon J, Greenbaum A, Israeli D, Melles GRJ, Bahar I, and Livny E
- Subjects
- Humans, Descemet Membrane, Keratoplasty, Penetrating
- Abstract
Competing Interests: Financial disclosures/conflicts of interest: None reported.
- Published
- 2022
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43. Functional and Structural Findings in Infants Treated for Retinopathy of Prematurity Using Optical Coherence Tomography Angiography.
- Author
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Shouchane-Blum K, Gal-Or O, Barayev E, Nemet A, Sternfeld A, Ben Ishai M, Axer-Siegel R, Erhlich R, and Friling R
- Subjects
- Child, Fluorescein Angiography methods, Fovea Centralis blood supply, Humans, Infant, Infant, Newborn, Retinal Vessels, Visual Acuity, Retinopathy of Prematurity diagnosis, Retinopathy of Prematurity surgery, Tomography, Optical Coherence methods
- Abstract
Background and Objective: To assess the foveal microvascular structure of children with retinopathy of prematurity (ROP) treated with diode laser photocoagulation using optical coherence tomography angiography (OCTA)., Patients and Methods: OCTA was performed at a tertiary medical center in 17 children (27 eyes) aged 4 to 16 years with a history of diode laser photocoagulation treated ROP. OCTA parameters were compared with those of 12 healthy age-matched controls (23 eyes) attending the orthoptics clinic and correlated with clinical factors., Results: Compared with controls, the ROP group had a smaller foveal avascular zone area ( P < .001), lower deep vascular plexus density ( P < .001), lower flow density ( P = .025), and greater central macular thickness ( P < .001). High intraventricular hemorrhage grade correlated with smaller foveal avascular zone area ( P = .008) and greater inner macular thickness ( P = .047). There was no impact of gestational age, birth weight, or refractive status., Conclusion: OCTA can identify significant quantifiable long-term macular microvascular and structural changes in this patient population. [ Ophthalmic Surg Lasers Imaging Retina . 2022;53(4):194-201.] .
- Published
- 2022
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44. Ophthalmologists and WhatsApp: Teleophthalmology is already here.
- Author
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Barayev E, Vorobichik Berar O, Dotan G, Skaat A, Gal-Or O, Gershoni A, and Gaton D
- Subjects
- Cross-Sectional Studies, Humans, Surveys and Questionnaires, Ophthalmologists, Ophthalmology, Physicians, Telemedicine
- Abstract
Purpose: To estimate the extent of WhatsApp utilization using text and media messages for inter-physician consultations among ophthalmologists (residents and specialists) at various clinical settings and its perceived benefits for ophthalmologists and their patients. We also aimed to detect obstacles that concern ophthalmologists when using WhatsApp as a consultation platform., Methods: This was a cross-sectional study using a self-administered survey through Google Forms, which was sent to 660 practicing ophthalmologists during April to May 2020., Results: One hundred and ninety-two ophthalmologists completed the questionnaire, 151 of which (78.6%) were specialists and 41 (21.4%) were residents. Most ophthalmologists reported using WhatsApp at least once a day for both personal and professional use. Residents reported lower rates of contacting patients using WhatsApp than specialists (1.51 ± 0.98 vs 2.72 ± 1.32, p < 0.001). Respondents reported WhatsApp consultations frequently replaced referrals of patients to other physicians, with a median of once a week. 97.8% of residents and 91.4% of specialists reported the ability to share media is a major advantage of WhatsApp over other medias, followed by rapid responses for consultations., Conclusion: Many ophthalmologists already use WhatsApp as a tool for professional consultations with other providers, mainly thanks to its simplicity and wide availability. Residents use it more frequently than specialists, and ranked it higher when asked how much WhatsApp has improved the clinical setting. Policy makers should address concerns brought up by physicians, such as documentation in medical records and proper compensation for consulting ophthalmologists during and after work hours.
- Published
- 2022
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45. Significance of Hyperreflective Foci as an Optical Coherence Tomography Biomarker in Retinal Diseases: Characterization and Clinical Implications.
- Author
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Fragiotta S, Abdolrahimzadeh S, Dolz-Marco R, Sakurada Y, Gal-Or O, and Scuderi G
- Abstract
Hyperreflective foci (HRF) is a term coined to depict hyperreflective dots or roundish lesions within retinal layers visualized through optical coherence tomography (OCT). Histopathological correlates of HRF are not univocal, spacing from migrating retinal pigment epithelium cells, lipid-laden macrophages, microglial cells, and extravasated proteinaceous or lipid material. Despite this, HRF can be considered OCT biomarkers for disease progression, treatment response, and prognosis in several retinal diseases, including diabetic macular edema, age-related macular degeneration (AMD), retinal vascular occlusions, and inherited retinal dystrophies. The structural features and topographic location of HRF guide the interpretation of their significance in different pathological conditions. The presence of HRF less than 30 μ m with reflectivity comparable to the retinal nerve fiber layer in the absence of posterior shadowing in diabetic macular edema indicates an inflammatory phenotype with a better response to steroidal treatment. In AMD, HRF overlying drusen are associated with the development of macular neovascularization, while parafoveal drusen and HRF predispose to macular atrophy. Thus, HRF can be considered a key biomarker in several common retinal diseases. Their recognition and critical interpretation via multimodal imaging are vital to support clinical strategies and management., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2021 Serena Fragiotta et al.)
- Published
- 2021
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46. Ocular Trauma Caused by Confetti Cannons.
- Author
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Ben Ishai M, Schaap Fogler M, Ehrlich R, Geffen N, Gal-Or O, Bahar I, and Dotan G
- Subjects
- Adult, Angiogenesis Inhibitors administration & dosage, Child, Choroidal Neovascularization prevention & control, Female, Fibrinolytic Agents therapeutic use, Humans, Intravitreal Injections methods, Male, Retrospective Studies, Trauma Severity Indices, Vision Tests methods, Visual Acuity, Bevacizumab administration & dosage, Corneal Injuries diagnosis, Corneal Injuries etiology, Corneal Injuries therapy, Eye Injuries etiology, Eye Injuries pathology, Eye Injuries physiopathology, Eye Injuries therapy, Hyphema diagnosis, Hyphema etiology, Hyphema therapy, Papilledema diagnosis, Papilledema etiology, Papilledema therapy, Tissue Plasminogen Activator therapeutic use
- Abstract
Background: Eye trauma is an unfortunate and often preventable cause of vision loss. Confetti cannons are common causes of injury. Awareness of ocular hazards of confetti cannons remains low because of limited reports describing ophthalmic injuries following their use., Objectives: To describe outcomes of ocular trauma caused by confetti cannons and to increase recognition of their ocular risks., Methods: A retrospective analysis was conducted of eye injuries caused by confetti cannons presenting to a single medical center between 2016 and 2020. Data collected included age, gender, eye injured, ocular damage, visual outcome, and details of surgeries performed., Results: Overall, six consecutive patients (2 males, mean age 19.5 ± 9.74 years) were identified and studied. In all patients only one eye was injured (3 right eyes) during a private celebration, most commonly (n=5) to a bystander while in the vicinity of a cannon operated by someone else. Most common eye injuries included corneal erosion (n=4), traumatic hyphema (n=4), and retinal edema (n=3). Mean initial logMAR visual acuity in the injured eye was 0.73 ± 0.18, improving to 0.25 ± 0.16 at the final visit (P = 0.125). Two patients underwent eye surgery due to their trauma: one to repair globe penetration and another to undergo intravitreal injection of tissue plasminogen activator and C3F8 for submacular hemorrhage, followed 8 months later by intravitreal bevacizumab injection for choroidal neovascularization., Conclusions: Confetti cannons pose hazards that can cause severe ocular trauma resulting in permanent vision loss. Increasing awareness of device hazards is necessary to prevent eye injuries.
- Published
- 2021
47. FULL-THICKNESS MACULAR HOLE IN AGE-RELATED MACULAR DEGENERATION PATIENTS WITH TWO DISTINCT ENTITIES: A Multicenter Study.
- Author
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Rabina G, Pillar S, Nemet A, Mimouni M, Levinger N, Chowers I, Ehrlich R, Gal-Or O, Barequet D, Rosenblatt A, Moisseiev E, Greifner H, Magal I, and Segal O
- Subjects
- Aged, Aged, 80 and over, Epiretinal Membrane physiopathology, Female, Follow-Up Studies, Humans, Macular Degeneration physiopathology, Male, Middle Aged, Retinal Perforations physiopathology, Retinal Pigment Epithelium physiopathology, Retrospective Studies, Tomography, Optical Coherence, Visual Acuity physiology, Epiretinal Membrane diagnostic imaging, Macular Degeneration diagnostic imaging, Retinal Perforations diagnostic imaging, Retinal Pigment Epithelium diagnostic imaging
- Abstract
Purpose: To describe optical coherence tomography characteristics of full-thickness macular holes (FTMHs) in age-related macular degeneration patients., Methods: A multicenter, retrospective, observational case series of patients diagnosed with age-related macular degeneration and FTMHs seen between January 1, 2009, and January 3, 2020. Clinical charts and spectral-domain optical coherence tomography images were reviewed. Optical coherence tomography findings included FTMH-inverted trapezoid or hourglass appearance, central macular thickness (CMT), complete retinal pigment epithelium and complete retinal outer retinal atrophy, and presence of pigment epithelium detachment and epiretinal membrane. The mean outcome was the morphologic and functional characterization of different subtypes of FTMHs., Results: A total of 86 eyes of 85 consecutive patients, with mean age of 80.31 ± 8.06 and mean best-corrected visual acuity of 1.17 ± 0.58 logarithm of the minimal angle of resolution. Two different subtypes of FTMHs were identified: tractional and degenerative. Fifty (58%) degenerative FTMHs characterized with inverted trapezoid appearance and 36 (42%) tractional FTMHs characterized with hourglass appearance. Degenerative FTMHs presented with 66% of CMT < 240 µm, 14% of CMT > 320, and 70% of complete retinal outer retinal atrophy, in comparison with 41% of CMT < 240 µm, 42.9% of CMT > 320%, and 20% of complete retinal outer retinal atrophy in the tractional FTMH group (P = 0.002, 0.003, <0.001, respectively). The presence of epiretinal membrane and pigment epithelium detachment where significantly higher in tractional FTMHs (P = 0.02, 0.03, respectively)., Conclusion: Degenerative and tractional FTMHs may be two distinct clinical entities. Discerning degenerative from tractional FTMHs is possible by using optical coherence tomography features including shape of the FTMHs, CMT, internal-external ratio of FTMHs, and presence of complete retinal outer retinal atrophy, pigment epithelium detachment, and epiretinal membrane.
- Published
- 2021
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48. Aflibercept clearance through the drainage system in a rat model.
- Author
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Keshet Y, Gal-Or O, Schaap Fogler M, Mimouni K, Ben Ishai M, Weinberger D, and Dotan A
- Abstract
Background: As intravitreal anti-VEGF injections became the mainstay of treatment for many retinal diseases, the cause of a secondary sustained elevated intraocular pressure is still unclear. The aim of our study was to study the clearance of Aflibercept from the anterior chamber angle, in a rat model, to test if an aggregation exists., Methods: Choroidal neovascular lesions (CNV) were induced in the right eye of 12 brown Norway rats, using indirect laser ophthalmoscope. Intravitreal Aflibercept injection (0.12 mg/3 µl) was performed 3 days after CNV induction. Rats were euthanized at predetermine time intervals of 3, 6, 24 and 48 h post injection, with immediate enucleation for histological analysis with H&E and immunofluorescence staining. Aflibercept molecules were stained with red fluorescence thanks to the formation of the immune complex Aflibercept-Rabbit anti human IgG-Anti rabbit antibodies-Cy3., Results: Immediately after the injection, a strong fluorescence signal was detected, indicating the presence of Aflibercept in the iridocorneal angle. At 3- and 6-h interval a strong signal of Aflibercept was still seen. Six hours post injection, the signal was highly concentrated in Schlemm's canal. In the 2 eyes harvested 24 h post Aflibercept injection, red fluorescence signal intensity was decreased in one eye, occupying mainly intra scleral venous plexuses, and absent in the other eye. At 48 h there was no fluorescence signal, confirming complete clearance of Aflibercept., Conclusions: In our rat model, a complete clearance of Aflibercept from the anterior chamber angle, was seen 48 h after the injection. This finding refutes the theory of possible connection between IOP elevation and mechanical obstruction. Evacuation time of Aflibercept through the angle is of the same magnitude as that of Bevacizumab in the same rat model., (© 2021. The Author(s).)
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- 2021
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49. Orbital Lymphatic-Venous Malformation Accompanied by an Intraocular Vascular Malformation: A Rare Case Study.
- Author
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Shouchane-Blum K, Yassur I, Sternfeld A, Regev M, Gal-Or O, Kornreich L, Ehrlich R, and Ehrenberg M
- Abstract
Lymphatic-venous malformations (LVMs) are development defects that result in abnormal connections between the lymphatic and venous systems. The authors describe a 7-weeks-old female infant who presented with a right orbital LVM extending to the ipsilateral cheek and subconjunctiva of the right eye, intracranial developmental venous anomalies in the right cerebellum, and a significant right eye intraocular retinal vascular malformation. Since orbital LVM is usually diagnosed in infancy or childhood, pediatric ophthalmologists should actively look for intraocular vascular malformations as such findings can poorly affect a patient's vision., Competing Interests: The authors declare that they have no competing interests., (Copyright © 2021 by S. Karger AG, Basel.)
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- 2021
- Full Text
- View/download PDF
50. ATYPICAL CONGENITAL HYPERTROPHY OF THE RETINAL PIGMENT EPITHELIUM COMPLICATED BY PRESUMED RETINAL PIGMENT EPITHELIAL ADENOMA AND EXUDATIVE MACULOPATHY.
- Author
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Mehta N, Gal-Or O, Barbazetto I, Modi Y, Shields CL, and Freund KB
- Subjects
- Adenoma drug therapy, Aged, Angiogenesis Inhibitors therapeutic use, Bevacizumab therapeutic use, Exudates and Transudates, Fluorescein Angiography, Humans, Hypertrophy congenital, Intravitreal Injections, Male, Multimodal Imaging, Retinal Diseases diagnosis, Retinal Diseases drug therapy, Retinal Neoplasms drug therapy, Retinal Pigment Epithelium abnormalities, Subretinal Fluid, Tomography, Optical Coherence, Vascular Endothelial Growth Factor A antagonists & inhibitors, Visual Acuity, Adenoma pathology, Retinal Diseases pathology, Retinal Neoplasms pathology, Retinal Pigment Epithelium pathology
- Abstract
Purpose: To report a retinal pigment epithelium (RPE) tumor with exudative maculopathy, originating from an atypical RPE lesion presumed to represent congenital hypertrophy of the RPE or RPE hyperplasia., Methods: Multimodal imaging including fundus autofluorescence, optical coherence tomography, fluorescein angiography, and optical coherence tomography angiography., Results: A 76-year-old West African man noted visual acuity reduction to count fingers in the right eye and 20/400 in the left eye. Features of chronic glaucoma were noted. In addition, there was a fairly well-circumscribed darkly pigmented RPE lesion in the paramacular region in the right eye, measuring 4 mm in diameter and flat and consistent with atypical congenital hypertrophy of the RPE or RPE hyperplasia. On the posterior margin of this mass was an RPE tumor, presumed to represent RPE adenoma, producing exudative maculopathy and cystoid macular edema. Multimodal imaging was used to distinguish the RPE tumor from macular neovascularization. A similar atypical congenital hypertrophy of the RPE without retinopathy measuring 3.5mm in diameter was noted in the temporal macular region in the left eye. After six monthly doses of intravitreal bevacizumab (1.25 mg/0.05 mL) in the right eye, the maculopathy resolved and the RPE mass showed partial involution with visual acuity return to baseline 20/200., Conclusion: Congenital hypertrophy of the RPE and RPE hyperplasia can produce RPE adenoma with related exudative maculopathy. In this case, the maculopathy responded to bevacizumab.
- Published
- 2021
- Full Text
- View/download PDF
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