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Reduced choriocapillaris flow in eyes with type 3 neovascularization and age-related macular degeneration
- Publication Year :
- 2018
-
Abstract
- Purpose: To study choriocapillaris (CC) flow in eyes with Type 3 neovascularization (NV) and age-related macular degeneration, using optical coherence tomography angiography analysis. Methods: In this multicenter, retrospective, observational study, we collected data from 21 patients with unilateral Type 3 NV and age-related macular degeneration, based on clinical examination, structural optical coherence tomography, and fluorescein angiography when available. An additional group of 20 nonneovascular age-related macular degeneration eyes with unilateral Type 1 or Type 2 NV due to age-related macular degeneration was included for comparison. En face optical coherence tomography angiography imaging (3 · 3 mm scans) with quantitative microvascular analysis of the CC was performed. Main outcome measures were: 1) the percent nonperfused choriocapillaris area; and 2) the average CC signal void size. Results: We included 21 patients with unilateral Type 3 NV (15 female, 71.5%) and 20 patients with unilateral Type 1 or 2 NV (9 female, 45.0% P = 0.118). Mean ± SD age was 82.1 ± 7.4 years in the unilateral Type 3 patients and 78.3 ± 8.1 in unilateral Type 1/2 NV subjects (P = 0.392). The percent nonperfused choriocapillaris area was 56.3 ± 8.1% in eyes with Type 3 NV and 51.9 ± 4.3% in the fellow eyes (P = 0.016). The average signal void size was also increased in those eyes with Type 3 NV (939.9 ± 680.9 mm 2 ), compared with the fellow eyes (616.3 ± 304.2 mm 2 , P = 0.039). The number of signal voids was reduced in the Type 3 NV eyes (604.5 ± 282.9 vs. 747.3 ± 195.8, P = 0.046). The subfoveal choroidal thickness was 135.9 ± 54.2 mm in eyes with Type 3 NV and 167.2 ± 65.4 mm in the fellow eyes (P = 0.003). In addition, the fellow eyes of patients with unilateral Type 3 NV displayed more significant CC flow abnormalities versus the fellow eyes with unilateral Type 1/2 NV (percent nonperfused choriocapillaris area = 51.9 ± 4.3% vs. 46.0 ± 2.1%, respectively, P, 0.0001; and average signal void size 616.3 ± 304.2 mm 2 versus 351.4 ± 65.5 mm 2 , respectively, P, 0.0001; and number of signal voids 747.3 ± 195.8 vs. 998.5 ± 147.3, respectively, P, 0.0001). Conclusion: Eyes with unilateral Type 3 NV illustrated increased CC nonperfusion versus fellow nonneovascular eyes. These results suggest that choroidal ischemia may play an important role in the development of Type 3 NV.
- Subjects :
- Male
0301 basic medicine
genetic structures
optical coherence tomography angiography
Neovascularization
Macular Degeneration
0302 clinical medicine
Retrospective Studie
Medicine
Fluorescein Angiography
Aged, 80 and over
medicine.diagnostic_test
General Medicine
Middle Aged
Fluorescein angiography
choriocapillaris flow
Female
medicine.symptom
type 3 neovascularization
Tomography, Optical Coherence
Human
medicine.medical_specialty
03 medical and health sciences
Ophthalmology
Age related
Type 3 neovascularization
Humans
age-related macular degeneration
Aged
Retrospective Studies
Choroid
business.industry
Age-related macular degeneration
Retrospective cohort study
Optical coherence tomography angiography
Macular degeneration
medicine.disease
Choroidal Neovascularization
eye diseases
Capillaries
Choriocapillari
Capillarie
030104 developmental biology
Multicenter study
030221 ophthalmology & optometry
sense organs
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2da7919a3a8c6692878f99fbcf2bb192