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1. Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes.

2. Novel insights into the GCN2 pathway and its targeting. Therapeutic value in cancer and lessons from lung fibrosis development.

3. Lost in translation? Evidence for a muted proteomic response to thermal stress in a stenothermal Antarctic fish and possible evolutionary mechanisms.

4. GCN2-SLC7A11 axis coordinates autophagy, cell cycle and apoptosis and regulates cell growth in retinoblastoma upon arginine deprivation

5. The stress sensor GCN2 differentially controls ribosome biogenesis in colon cancer according to the nutritional context

6. General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases.

7. The stress sensor GCN2 differentially controls ribosome biogenesis in colon cancer according to the nutritional context.

8. Gcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response.

9. Computational modeling of the synergistic role of GCN2 and the HPA axis in regulating the integrated stress response in the central circadian timing system.

10. Multifaceted role of GCN2 in tumor adaptation and therapeutic targeting

11. General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases

13. Enhancing Leukemia Treatment: The Role of Combined Therapies Based on Amino Acid Starvation.

14. Emerging Role of GCN1 in Disease and Homeostasis.

15. General Control Non-derepressible 2 Alleviates Cartilage Degeneration and Inhibits NLRP3 Inflammasome Activation in Osteoarthritis.

16. Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice.

17. Multiplexed suppression of TOR complex 1 induces autophagy during starvation

18. The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

19. Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase

20. Cellular Stress: Modulator of Regulated Cell Death.

21. The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity.

22. FGF21, not GCN2, influences bone morphology due to dietary protein restrictions.

23. Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell.

24. Targeting the integrated stress response in hematologic malignancies

25. GCN2 kinase‐mediated upregulation of ubiquitin C maintains intracellular glutamine level and tRNAGln(CUG) charging under amino acid starvation.

26. l-Asparaginase regulates mTORC1 activity via a TSC2-dependent pathway in pancreatic beta cells.

27. Modulation of GCN2/eIF2α/ATF4 Pathway in the Liver and Induction of FGF21 in Young Goats Fed a Protein- and/or Phosphorus-Reduced Diet.

28. Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7‐deficient cells

29. Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons

30. Multiple Roles of the Stress Sensor GCN2 in Immune Cells.

31. 精氨酸对斑玉蕈菌丝生长的影响.

32. IDO1 inhibitors are synergistic with CXCL10 agonists in inhibiting colon cancer growth.

33. Structural and functional characterisation of the nutrient sensing kinase GCN2

34. Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice

35. The antitumor activity of a novel GCN2 inhibitor in head and neck squamous cell carcinoma cell lines

36. Targeting the integrated stress response in hematologic malignancies.

37. Investigation of plant responses to foreign double-stranded RNA

38. Cryo-EM structure of histidyl-tRNA synthetase-like domain reveals activating crossed helices at the core of GCN2.

39. Multifaceted role of GCN2 in tumor adaptation and therapeutic targeting.

40. Modulation of GCN2 activity under excess light stress by osmoprotectants and amino acids

41. Restricting a single amino acid cross-protects Drosophila melanogaster from nicotine poisoning through mTORC1 and GCN2 signalling

42. Cellular Stress: Modulator of Regulated Cell Death

43. Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7‐deficient cells.

44. The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages.

45. Genetic and Pharmacological Inhibition of GCN2 Ameliorates Hyperglycemia and Insulin Resistance in Type 2 Diabetic Mice.

46. Multi-Omics Analysis of Low-Temperature Fruiting Highlights the Promising Cultivation Application of the Nutrients Accumulation in Hypsizygus marmoreus.

47. Activation of the eIF2α-ATF4 Pathway by Chronic Paracetamol Treatment Is Prevented by Dietary Supplementation with Cysteine.

48. HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection

49. GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

50. GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer.

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