General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases.

The function of General Control Nonderepressible 2 (GCN2), an evolutionaryconserved component of the integrated stress response (ISR), has been welldocumented across organisms from yeast to mammals. Recently GCN2 has also gained attention for its role in health and disease states. In this review, we provide a brief overview of GCN2, including its structure, activation mechanisms and interacting partners, and explore its potential significance as a therapeutic target in various age-related diseases including neurodegeneration, inflammatory disorders and cancer. Finally, we summarize the barriers to effectively targeting GCN2 for the treatment of disease and to promote a healthier aging process. [ABSTRACT FROM AUTHOR]