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2 results on '"GASTROINTESTINAL INFLAMMATORY DISEASE"'

1. cGAS–STING signaling pathway in gastrointestinal inflammatory disease and cancers.

Author

Ke, Xinxin, Hu, Tao, and Jiang, Mizu

Abstract

Cyclic GMP‐AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway has emerged as a key DNA‐sensing machinery in innate immunity. Activation of cGAS–STING signaling pathway mediates the production of interferons and proinflammatory cytokines. Although cGAS–STING signaling pathway shows critical function in the maintenance of gut homeostasis, overactive cGAS–STING signaling pathway leads to gastrointestinal (GI) inflammation. Harnessing the effect and mechanism of the cGAS–STING signaling pathway could be beneficial for the development of novel strategies for the treatment of GI diseases. This review presents recent advances regarding the role of cGAS–STING signaling pathway in GI inflammatory disease and cancers and describes perspective therapeutic strategies targeting the signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2022
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2. Importance of IL-10 Modulation by Probiotic Microorganisms in Gastrointestinal Inflammatory Diseases

Author

Jean Guy LeBlanc, Silvina del Carmen, Clarissa Santos Rocha, Alejandra de Moreno de LeBlanc, Vasco Azevedo, Meritxell Zurita-Turk, Maarten van de Guchte, Anderson Miyoshi, Centro de Referencia para Lactobacilos [Tucumán] (CERELA), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Institute of Biological Sciences, Universidade Federal de Minas Gerais, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, and Institute of Biological Science

Subjects
Interleukin 10, probiotic microorganisms, gastrointestinal inflammatory diseases, Microorganism, [SDV]Life Sciences [q-bio], Otras Ciencias Biológicas, Disease, Review Article, microorganisme probiotique, law.invention, purl.org/becyt/ford/1 [https], Ciencias Biológicas, 03 medical and health sciences, Probiotic, 0302 clinical medicine, Immune system, Mediator, law, LACTIC ACID BACTERIA, Medicine, purl.org/becyt/ford/1.6 [https], inflammation gastrointestinale, 030304 developmental biology, 0303 health sciences, Heterogeneous group, business.industry, Genetically engineered, PROBIOTICS, Biotechnology, interleukine 10, GASTROINTESTINAL INFLAMMATORY DISEASE, Immunology, IL-10, 030211 gastroenterology & hepatology, business, CIENCIAS NATURALES Y EXACTAS
Abstract

Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of one of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of gastrointestinal inflammatory disease through their immune-modulating properties. A special emphasis will be placed on the critical role of the anti-inflammatory cytokine IL-10, and a brief overview of the uses of genetically engineered LAB that produce this important immune response mediator will also be discussed. Thus, this paper will demonstrate the critical role that IL-10 plays in gastrointestinal inflammatory diseases and how probiotics could be used in their treatment. Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Zurita Turk, Meritxell. Universidade Federal de Minas Gerais; Brasil Fil: Santos Rocha, Clarissa. Universidade Federal de Minas Gerais; Brasil Fil: van de Guchte, Maarten. Institut National de la Recherche Agronomique; Francia Fil: Azevedo, Vasco. Universidade Federal de Minas Gerais; Brasil Fil: Miyoshi, Anderson. Universidade Federal de Minas Gerais; Brasil Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina

Published
2011

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