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Our primary objective was to validate the French version of the BFI-10, an ultra-short ten-item version of the Big Five Inventory (BFI; John et al., 1991), which allows for a reasonably accurate assessment of personality in circumstances in which more in-depth assessment is not possible. In order to reach a thorough evaluation of the external validity, we also aimed to examine the bandwidth of the BFI-10 scales with reference to the study by De Young, Quilty and Peterson (2007) who distinguished between two aspects in each of the Big Five: Assertiveness and Enthusiasm for Extraversion; Compassion and Politeness for Agreeability; Orderliness and Productiveness for Conscientiousness; Withdrawal and Volatility for Negative Emotionality, and finally Openness to Aesthetics and Openness to Ideas for Open-Mindedness. Our concern with regard to bandwidth was to examine whether the BFI-10 scales have strong enough correlations with both aspects of each domain.Participants. Data from four samples were analysed: Sample 1 comprised 2499 undergraduate students (1654 women) who completed the full BFI in university classes; Sample 2 comprised 13,306 participants (8471 women) who filled out the BFI-10 ten items online via Internet; Sample 3 comprised 143 undergraduate students (115 women) who completed the full BFI twice with a two-week interval; Sample 4 comprised 360 undergraduate students (183 women) who filled out the BFI and NEO PI-R.The French version of the Big Five Inventory is a 45-item inventory, which measures the five broader domains of personality. The ultrashort Ten-item Big Five Inventory (BFI-10) was developed simultaneously in German and English by Rammstedt and John (2007); it comprises five two-item scales measuring the big five domains. The Neuroticism-Extraversion-Openness Personality Inventory Revised (NEO PI-R; Costa et McCrae, 1992) is a 240-item questionnaire which assesses the big five domains and 30 lower-order facets, i.e. six facets per domain.Factor structure and reliability of the five two-item scales were first investigated on samples 1 and 3. Confirmatory factor analyses (CFAs) were conducted on samples 1 and 2, and discriminant validity was assessed via comparison with the NEO PI-R (sample 4). In order to examine the bandwidth of the BFI-10 two-item scales, we studied their correlation not only with the NEO PI-R domains but also with the 30 facets.The CFAs showed the good fit of the five-factor structure, with RMSEA=.077 (.072), CFI=.974 (.956), and SRMR=.029 (.027) in samples 1 and 2 respectively. Multigroup CFA conducted in groups 1 and 2 showed invariance across gender of factor loadings and item intercepts. Test-retest reliability was satisfactory with rs ranging from .68 (Open-Mindedness) to .86 (Extraversion and Negative Emotionality). The comparison of the two-item scales with the NEO PI-R scales showed high correlations not only with the NEO domain scales, but also with several facets: Four BFI-10 two-item scales (Extraversion, Conscientiousness, Negative Emotionality, and Open-Mindedness) were highly correlated with at least three of the six NEO facet scales in each domain. For Agreeableness, the magnitude of correlations was smaller, but the pattern of correlations was the same. All BFI-10 scales had at least moderate correlations with both aspects of each domain, with the exception of Negative Emotionality, which measured the NEO Withdrawal aspect better than Volatility.The French version of the BFI-10 demonstrated the expected five-factor structure, satisfactory reliability, and broad bandwidth. It could be a valuable tool for the assessment of personality in circumstances in which it is not possible to use a longer and more in-depth instrument, especially when personality is not the main focus of research but one of the variables to be controlled.

L'acquisition d'un scanner intra-oral est une revolu- tion dans un cabinet orthodontique car le flux numerique genere modifie l'organisation et redefinit totalement les interactions avec nos patients, confreres et prothesistes. La technologie et le mode de fonctionnement sont essentiels a apprehender afin de faire le bon choix de materiel.

The Big Five Inventory (BFI) developed by John et al. (1991) is one of the most widely accepted tools for assessing dimensions of personality. It comprises 44 items that assess five broad dimensions of personality (the Big Five Factors): Extraversion, Agreeableness, Conscientiousness, Neuroticism and Openness to experience. Based on correlations with the facets described in the NEO Personality Inventory Revised (NEO PI-R), another Big Five assessment tool with 240 items and 6 facets per dimension, Soto and John (2009) showed that the dimensions in the BFI could be divided into two facets each (ten facets altogether). These results are in line with those of DeYoung et al. (2007), who ran factorial analyses with all the NEO PI-R facets and the International Personality Item Pool (IPIP) and identified ten intermediate factors (between facets and dimensions) which they called "aspects" (two per dimension). The goal of the present study is to investigate the ten facets described by Soto and John in a French sample, using the French version of the BFI (BFI-Fr), which has good psychometric properties, and to check whether the pattern of correlations of these facets with the NEO PI-R match those of the American version.We created three groups. The first comprised 360 students from the Institut libre d'éducation physique supérieure (ILEPS) and Tours University (psychology undergraduates). Participants (mean age 21.1 years±2.30; 58% women) completed the BFI-Fr and the NEO PI-R. The second comprised 142 psychology students from Tours University (mean age 20.6 years±1.78; 81% women); they completed the BFI-Fr twice, two weeks apart (test and retest). The third comprised 252 psychology students from Paris-Nanterre University (mean age 23 years±4.2; 89% women) who described a total of 405 people they knew well (mean age 35.2±10.8; 49% women) using the peer-report format of the BFI-Fr.In the self-report format, eight of Soto and John's ten aspects had acceptable internal consistency (based on Guildford's (1954) internal consistency criteria, due to the small number of items), with Cronbach's α between 0.60 and 0.86 and test-retest correlations between 0.71 and 0.89, showing satisfactory temporal stability. We found a single facet for Extraversion (Assertiveness), two for Agreeableness (Altruism and Compliance), two for Conscientiousness (Self-Discipline and Order), one for Neuroticism (Anxiety), and two for Openness to Experience (Openness to aesthetics and Openness to ideas). Based on their convergence with the corresponding facets in the NEO PI-R, these eight facets showed satisfactory external validity. With regard to the peer-report format, the Activity facet of Extraversion, which did not have sufficient internal consistency in the self-report format, had acceptable properties (i.e. 9 out of 10 facets). Only the Depression facet of Neuroticism still had insufficient internal consistency. In this study, we proposed an improvement of two facets (Activity and Compliance) and added one facet specific to the French version (Emotional Instability) in place of the Depression facet.We showed that the BFI-Fr can be used to assess nine of the ten facets described by Soto and John. We also identified an Emotional Instability facet, replacing the Depression facet of Neuroticism. DeYoung et al. (2007) considered that anxiety and depression are indissociable and can be represented by a Neuroticism aspect they labeled Withdrawal. They suggested a second aspect of this dimension they called Volatility (with the N2 Angry Hostility facet of the NEO PI-R as main marker and the N5 Impulsiveness and N3 Depression as secondary markers). The Emotional Instability facet we found corresponds closely to the N2 Angry Hostility facet of the NEO PI-R and appears to be a satisfactory marker of DeYoung et al.'s (2007) Volatility aspect. Although this study has limitations, particularly related to the samples (students), the BFI-Fr facets (derived from those defined by Soto and John in the BFI or proposed as improvements on the original facets) match the corresponding NEO PI-R facets and can also be seen as main markers of the aspects defined by DeYoung et al.

Resume L’objectif de cette etude est d’explorer un lien entre un vecu d’abus sexuel et une situation d’inaptitude a l’education physique et sportive ( eps ), appelee communement « dispense de sport ». Population Nous avons interviewe 361 adolescents de classe de seconde de deux lycees d’enseignement general ou des eleves de niveau equivalent (premiere annee de bep ) d’un lycee d’enseignement professionnel de Tours (France) : soit 43 % de garcons, n = 151 et 57 % de filles, n = 204 ; âge moyen 16,58 ans, ET 0,87 an et etendue 4,67 ans. Materiel Des questions exploraient un vecu anterieur d’abus sexuel (attouchements [1] ou sexualite forcee [2]) et le fait d’avoir deja beneficie au cours de sa scolarite d’un certificat d’inaptitude a l’ eps : (a) a l’annee, (b) de plus de trois mois, (c) pour des durees breves, mais repetees et representant au total plus de trois mois et (d) le fait d’etre parfois absent du cours sans raison valable. Ces questions etaient completees par des echelles sur la sante psychique (General Health Questionnaire, Goldberg 1972), l’estime de Soi (Rosenberg’s Self-Esteem Scale, Rosenberg 1965) et le niveau d’ideation suicidaire (Suicidal Ideation Questionnaire, Reynolds 1987). Procedure En avril 2004 en classe (anonymat garanti et participation basee sur le volontariat). Resultats La prevalence des abus sexuels parmi ceux qui ont beneficie d’une inaptitude a l’ eps est importante. Le vecu d’attouchements (1) parmi (a) les inaptitudes annuelles concerne 10,8 % des filles (n = 3) ; (b) 32,1 % (n = 9) pour les inaptitudes de plus de trois mois et (c) 50 % (n = 28) pour celles cumulees. Le seul garcon concerne n’a beneficie d’aucun certificat d’inaptitude. Le vecu d’une sexualite forcee (2) concerne respectivement (a) 16,7 % des filles (n = 2), (b) 41,7 % (n = 5) et (c) 50 % (n = 6). Tandis qu’un des deux garcons concerne a beneficie de toutes les formes de certificat d’inaptitude. Ces resultats sont confirmes par une analyse de variance. Pour les adolescentes, nous ne retrouvons un effet significatif que sur les inaptitudes de courte duree et cumulees (superieures a trois mois d’arret) pour le vecu de violences sexuelles, ou de rapport sexuel force. Pour les garcons, il existe une influence de la sexualite contrainte sur les inaptitudes annuelles. Une recherche de correlations complete cette approche. On retrouve un lien entre inaptitudes cumulees (superieures trois mois) et un vecu d’attouchements, et de relations sexuelles contraintes. Il existe egalement une relation significative entre les inaptitudes superieures a trois mois et les relations sexuelles forcees, et des liens entre l’absenteisme au cours d’ eps et les deux situations d’abus. Ces resultats ont ete completes par l’etude des relations entre ce vecu d’abus sexuel et les variables psychologiques : les filles concernees presentent une plus grande morbidite psychique, une moins bonne estime d’elles-memes et davantage d’ideations suicidaires. Discussion Cette etude montre l’existence d’un lien entre inaptitude a l’ eps et vecu d’abus sexuel. L’expression de la souffrance psychique au travers d’une demande de certificat pour inaptitude a l’ eps est moins reperable que des conduites a risque « bruyantes ». Par consequent, toute demande d’inaptitude a l’ eps de longue duree (annuelle ou de plus de trois mois) doit attirer l’attention des professionnels. Celles de courte duree et qui se repetent doivent faire l’objet d’une vigilance accrue, puisqu’elles ne sont pas controlees par le medecin scolaire. Ces situations d’inaptitudes ne peuvent etre systematiquement rapprochees d’un vecu d’abus sexuel, mais elles sont une bonne occasion d’evaluer la sante psychique de l’adolescent, la qualite de son soutien social et du fonctionnement familial. Cette recherche apporte des premiers constats qu’il s’agira de completer par des travaux ulterieurs.

Resume Cette revue de litterature a pour objectif de presenter les travaux realises sur les determinants psychologiques de la blessure physique dans le contexte sportif. Ceux-ci mettent majoritairement en evidence le role du stress dans la survenue de blessures. D'autres recherches menees en psychologie de la sante peuvent toutefois initier des reflexions complementaires en caracterisant d'autres processus susceptibles de conduire le sportif a se blesser. Au-dela des dysfonctionnements resultant du vecu d'un episode de stress, certaines approches mettent notamment l'accent sur l'influence pathogene de l'adoption volontaire de comportements a risque ou l'influence salutogene de l'engagement dans des comportements de protection, et sur les determinants lies a l'adoption de ces comportements. Peu d'etudes cependant ont cherche a demontrer la pertinence de ces determinants dans l'identification des sportifs susceptibles de se blesser. Un modele est suggere afin d'engager les recherches selon cette perspective.

L'hypercondylie est une pathologie autonome se caracterisant par un defaut du controle de la croissance lie tres probablement a un dereglement des boucles de retro-action entre les differentes couches histologiques, qui induirait une persistance de la multiplication des cellules prechondroblastiques.Cliniquement, elle se caracterise par une face asymetrique disgracieuse typique, avec une anatomie mandibulaire, une occlusion perturbees et un plan d'occlusion bascule. Cependant, la forme clinique presentee par les jeunes patients de nos cabinets est souvent naissante, et les signes restent frustes : il est donc tres difficile de diagnostiquer l'hypercondylie. Or, en l'absence de diagnostic, cette pathologie conduit ineluctablement a l'echec therapeutique lorsqu'elle est evolutive.La scintigraphie est une excellente methode d'investigation de l'activite osseuse permettant d'apprehender la croissance et l'activite du cartilage condylien. Ainsi, elle permet de preciser la nature active ou inactive de la pathologie et, de ce fait, de modifier le plan de traitement. Alors, une prise en charge plus precoce est possible et permet de limiter l'acte chirurgical a une condylectomie associee imperativement a un traitement orthodontique pour parfaire le resultat esthetique et fonctionnel.

Acquisition of an intraoral scanner leads to an in-office revolution. Indeed, the digital workflow causes organizational changes and deeply modifies the relationship with the patients, other practitioners, and laboratory technicians. That is the reason why practitioners need to understand intraoral scanner technology and operating processes to make a convenient choice.

This paper describes the total enzymatic synthesis of Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) in which all residues were labelled with tritium. Carboxypeptidase Y from Saccharomyces cerevisiae was the coupling enzyme. [3H]-Tyr-NH2, [3H]-Gly-Oet, [3H]-Phe-NH2 and [3H]-Leu-NH2 were prepared with specific radioactivities ranging between 20 and 60 Ci/mmol (740 to 2220 GBq/mmol). Using a microscale procedure, we obtained a fully tritiated hormone having a specific radioactivity equal to 139 Ci/mmol (5143 GBq/mmol), in agreement with the summation of the specific radioactivities of constituting residue. The radioactive hormone had antigenic properties identical to those of native Leu-enkephalin. It also bound to rat brain opiate receptors like the parental hormone.

The LAZ3/BCL6 gene on chromosone 3q27 is recurrently disrupted in B cell non-Hodgkin's lymphomas by translocations involving immunoglobulin genes or other chromosone regions. We have cloned the breakpoint region and chromosone derivatives of the t(3;11)(q27;q23.1) translocation, present in a B cell leukemia cell line (Karpas 231), which define a novel 11q23.1 breakpoint site. As a consequence of the translocation, LAZ3 regulatory regions upstream of non-coding exon 2 are replaced by those of BOB1/OBF1, a recently described B cell-specific coactivator of octamer-binding transcription factors. A detailed structural study of the BOB1/OBF1 genomic DNA and of a nearly full-length cDNA revealed particular features in the 3' untranslated region, such as an Alu motif and a polymorphic tetranucleotide microsatellite. Two mutations leading to two potential amino acid changes in the C-terminal region, were also detected in one allele of a lymphoma B cell line, Raji. Due to its cell-specific expression and role as a coactivating transcription factor, chromosomal translocation and/or point mutation of BOB1/OBF1 may contribute to B cell tumorigenesis.

The LAZ3/BCL6 gene on chromosome 3q27 is recurrently disrupted in B-cell non Hodgkin's lymphomas by translocations involving immunoglobulin genes or other chromosome regions. We have studied the t(3; 11) (q27; q23) translocation, present in a B-cell leukemia cell line (Karpas 231). As a consequence of this translocation, a LAZ3 chimeric transcript was created by fusion, 5' to the LAZ3 exon 2, with a transcribed sequence identical to BOB1/OBF1, a B cell-specific coactivator of octamer-binding transcription factors, recently described. Nucleotidic sequence of a nearly full-length cDNA of the BOB1/OBF1 gene revealed particular features in the 3' untranslated region of the gene, including pyrimidine-rich sequence repeats, an Alu motif, and a polymorphic [CCTT] tetranucleotide microsatellite. Two A to G transition mutations were also detected in the coding region of one allele of a lymphoma B-cell line, Raji, leading to 2 amino-acid changes in the C-terminal region. Due to its cell-specificity and role as a coactivating transcription factor, chromosomal translocation and/or perhaps point mutation of BOB1/OBF1 may contribute to B cell tumorigenesis.

This paper was presented at the Seventh International Conference of Hydrogen Safety (ICHS 2017) in Hamburg on 11-13 September 2017. The paper summarises the results from a blind-prediction study for models developed for estimating the consequences of vented hydrogen deflagrations. The work is part of the project Improving hydrogen safety for energy applications through pre-normative research on vented deflagrations (HySEA). The scenarios selected for the blind-prediction entailed vented explosions with homogeneous hydrogen-air mixtures in a 20-foot ISO container. The test program included two configurations and six experiments, i.e. three repeated tests for each scenario. The comparison between experimental results and model predictions reveals reasonable agreement for some of the models, and significant discrepancies for others. It is foreseen that the first blind-prediction study in the HySEA project will motivate developers to improve their models, and to update guidelines for users of the models. The paper is a deliverable from the project “Improving hydrogen safety for energy applications through pre-normative research on vented deflagrations”, or HySEA (www.hysea.eu), which receives funding from the Fuel Cells and Hydrogen Joint Undertaking (FCH JU) under grant agreement no. 671461. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and United Kingdom, Italy, Belgium and Norway.

FK-33-824 (Try-D-Ala-Gly-MePhe-Met(O)ol) is a potent enkephalin analog which has been tritium labelled with a high specific radioactivity (41 Ci/mmole). The labelled drug exhibits specific and saturable binding to rat brain crude mitochondrial fraction. Specific binding is inhibited by low concentrations of morphine, levallorphan and beta-endorphin, suggesting that FK 33-824 [3H] binds preferentially to mu opiate sites. Binding studies at equilibrium and kinetics of formation and dissociation of the labelled ligand-receptor complex indicate that FK 33-824 [3H] binds to two classes of specific sites. Their affinities are distinguishable at 0 degree (KD = 1.3 and 5.8 nM) and very close to each other at 37 degree (KD = 1.9 nM).

The diacetyl derivative of 4-hydroxyaminoquinoline 1-oxide, the proximate carcinogen of 4-nitroquinoline 1-oxide, was reacted in vitro with native and heat denatured chicken erythrocyte DNA under various conditions. The amount of fixed carcinogen was obtained by using the labeled diacetyl derivative and from this result the molar extinction coefficients of bound carcinogen were calculated in order to allow a direct spectrophotometric determination. A decrease in melting temperature of DNA samples modified by O,O'-diacetyl 4-hydroxyaminoquinoline 1-oxide (di Ac-4HAQO) was measured: the melting temperature depression value is equal to 1.4 degrees C per 1% of modified DNA bases. This result was compared with the values previously obtained by Fuchs and coworkers (Fuchs, R. and Daune, M. (1973) FEBS Lett, 34, 295-298 and Fuchs, R. Lefebvre, J.F., Pouyet, J. and Daune, M. (1976) Biochemistry 15, 3347-3351) for N-acetoxy-N-2-acetylaminofluorene-modified DNA and by Lang et al. [25] for the phenanthrylation of the DNA bases of N-acetoxy-N-2-acetylaminophenanthrene-modified DNA.