Search

Tendinopathy is a common musculoskeletal disorder characterized by chronic low-grade inflammation and tissue degeneration. Tendons have poor innate healing ability and there is currently no cure for tendinopathy. Studies elucidating mechanisms underlying the pathogenesis of tendinopathy and mechanisms mediating the genesis of tendons during development have provided novel targets and strategies to enhance tendon healing and repair. This review summarizes the current understanding and treatments for tendinopathy. The review also highlights recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer-sized extracellular vesicles secreted from cells, for the treatment of tendinopathy. [ABSTRACT FROM AUTHOR]

The article presents a preliminary report on the jaw-opening reflex as a pain response in rabbits. The purpose of this study was to clarify that nature of the jaw-opening reflex by differential blockage of the inferior dental nerve components with decreasing concentrations of local anesthetic. The authors used pentobarbital on the rabbits to anesthetize them. Article topics in an electromyographic response, procaine, and lidocaine. The authors concluded that the stimulated response could be regarded as a pain response.