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5. Changes in upper airways microbiota in ventilator-associated pneumonia

Author

Alagna, Laura, Mancabelli, Leonardo, Magni, Federico, Chatenoud, Liliane, Bassi, Gabriele, Del Bianco, Silvia, Fumagalli, Roberto, Turroni, Francesca, Mangioni, Davide, Migliorino, Guglielmo M., Milani, Christian, Muscatello, Antonio, Nattino, Giovanni, Picetti, Edoardo, Pinciroli, Riccardo, Rossi, Sandra, Tonetti, Tommaso, Vargiolu, Alessia, Bandera, Alessandra, Ventura, Marco, Citerio, Giuseppe, and Gori, Andrea

Published
2023
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8. Multiple-magnon excitations shape the spin spectrum of cuprate parent compounds

Author

Betto, Davide, Fumagalli, Roberto, Martinelli, Leonardo, Rossi, Matteo, Piombo, Riccardo, Yoshimi, Kazuyoshi, Di Castro, Daniele, Di Gennaro, Emiliano, Sambri, Alessia, Bonn, Doug, Sawatzky, George A., Braicovich, Lucio, Brookes, Nicholas B., Lorenzana, Jose, and Ghiringhelli, Giacomo

Subjects
Condensed Matter - Superconductivity
Abstract

Thanks to high resolution and polarization analysis, resonant inelastic x-ray scattering (RIXS) magnetic spectra of La2CuO4, Sr2CuO2Cl2 and CaCuO2 reveal a rich set of properties of the spin 1/2 antiferromagnetic square lattice of cuprates. The leading single-magnon peak energy dispersion is in excellent agreement with the corresponding inelastic neutron scattering measurements. However, the RIXS data unveil an asymmetric lineshape possibly due to odd higher order terms. Moreover, a sharp bimagnon feature emerges from the continuum at (1/2,0), coincident in energy with the bimagnon peak detected in optical spectroscopy. These findings show that the inherently complex spin spectra of cuprates, an exquisite manifestation of quantum magnetism, can be effectively explored by exploiting the richness of RIXS cross sections., Comment: 7 pages, 3 figures

Published
2021
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11. Large polarons as key quasiparticles in SrTiO3 and SrTiO3-based heterostructures

Author

Geondzhian, Andrey, Sambri, Alessia, De Luca, Gabriella M., Di Capua, Roberto, Di Gennaro, Emiliano, Betto, Davide, Rossi, Matteo, Peng, Ying Ying, Fumagalli, Roberto, Brookes, Nicholas B., Braicovich, Lucio, Gilmore, Keith, Ghiringhelli, Giacomo, and Salluzzo, Marco

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

Despite its simple structure and low degree of electronic correlation, SrTiO$_3$ (STO) features collective phenomena linked to charge transport and, ultimately, superconductivity, that are not yet fully explained. Thus, a better insight in the nature of the quasiparticles shaping the electronic and conduction properties of STO is needed. We studied the low energy excitations of bulk STO and of the LaAlO$_{3}$/SrTiO$_{3}$ two dimensional electron gas (2DEG) by Ti L$_3$ edge resonant inelastic x-ray scattering. In all samples, we find the hallmark of polarons in the form of intense $dd$+phonon excitations, and a decrease of the LO3-mode electron-phonon coupling when going from insulating to highly conducting STO single crystals and heterostructures. Both results are attributed to the dynamic screening of the large polaron self-induced polarization, showing that the low temperature physics of STO and STO-based 2DEGs is dominated by large polaron quasiparticles., Comment: 5 pages, 4 figures

Published
2020
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12. Crystalline and magnetic structure of Ba2CuO3+{\delta} investigated by x-ray absorption spectroscopy and resonant inelastic x-ray scattering

Author

Fumagalli, Roberto, Nag, Abhishek, Agrestini, Stefano, Garcia-Fernandez, Mirian, Walters, Andrew C., Betto, Davide, Brookes, Nicholas B., Braicovich, Lucio, Zhou, Ke-Jin, Ghiringhelli, Giacomo, and Sala, Marco Moretti

Subjects
Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

Motivated by the recent synthesis of Ba$_2$CuO$_{3+\delta}$ (BCO), a high temperature superconducting cuprate with putative $d_{3z^2-r^2}$ ground state symmetry, we investigated its electronic structure by means of Cu $L_3$ x-ray absorption (XAS) and resonant inelastic x-ray scattering (RIXS) at the Cu $L_3$ edge on a polycrystalline sample. We show that the XAS profile of BCO is characterised by two peaks associated to inequivalent Cu sites, and that its RIXS response features a single, sharp peak associated to crystal-field excitations. We argue that these observations are only partially compatible with the previously proposed crystal structure of BCO. Based on our spectroscopic results and on previously published powder diffraction measurements, we propose a crystalline structure characterized by two inequivalent Cu sites located at alternated planes along the $c$ axis: nominally trivalent Cu(1) belonging to very short Cu-O chains, and divalent Cu(2) in the oxygen deficient CuO$_ {1.5}$ planes. We also analyze the low-energy region of the RIXS spectra to estimate the magnitude of the magnetic interactions in BCO and find that in-plane nearest neighbor superexchange exceeds 120~meV, similarly to that of other layered cuprates. Although these results do not support the pure $d_{3z^2-r^2}$ ground state scenario, they hint at a significant departure from the common quasi-2D electronic structure of superconducting cuprates of pure $d_{x^2-y^2}$ symmetry.

Published
2020
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13. Mobile orbitons in Ca$_2$CuO$_3$: crucial role of the Hund's exchange

Author

Fumagalli, Roberto, Heverhagen, Jonas, Betto, Davide, Arpaia, Riccardo, Rossi, Matteo, Di Castro, Daniele, Brookes, Nicholas B., Sala, Marco Moretti, Daghofer, Maria, Braicovich, Lucio, Wohlfeld, Krzysztof, and Ghiringhelli, Giacomo

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

We investigate the Cu $L_3$ edge resonant inelastic x-ray scattering (RIXS) spectra of a quasi-1D antiferromagnet Ca$_2$CuO$_3$. In addition to the magnetic excitations, which are well-described by the two-spinon continuum, we observe two dispersive orbital excitations, the $3d_{xy}$ and the $3d_{yz}$ orbitons. We carry out a quantitative comparison of the RIXS spectra, obtained with two distinct incident polarizations, with a theoretical model. We show that any realistic spin-orbital model needs to include a finite, but realistic, Hund's exchange $J_H \approx 0.5$ eV. Its main effect is an increase in orbiton velocities, so that their theoretically calculated values match those observed experimentally. Even though Hund's exchange also mediates some interaction between spinon and orbiton, the picture of spin-orbit separation remains intact and describes orbiton motion in this compound., Comment: 13 pages, 10 figures

Published
2020
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14. Successful Versus Failed Transition From Controlled Ventilation to Pressure Support Ventilation in COVID-19 Patients: A Retrospective Cohort Study

Author

Polo Friz, Melisa, Rezoagli, Emanuele, Safaee Fakhr, Bijan, Florio, Gaetano, Carlesso, Eleonora, Giudici, Riccardo, Forlini, Clarissa, Tardini, Francesca, Langer, Thomas, Laratta, Matteo, Casella, Giampaolo, Forastieri Molinari, Andrea, Protti, Alessandro, Cecconi, Maurizio, Cabrini, Luca, Biagioni, Emanuela, Berselli, Angela, Mirabella, Lucia, Tonetti, Tommaso, De Robertis, Edoardo, Grieco, Domenico Luca, Antonelli, Massimo, Citerio, Giuseppe, Fumagalli, Roberto, Foti, Giuseppe, Zanella, Alberto, Grasselli, Giacomo, Bellani, Giacomo, Guzzardella, Amedeo, Vivona, Luigi, Scaravilli, Vittorio, Colombo, Sebastiano, Cacioppola, Alessio, Brioni, Matteo, Forlini, Clarissa, Tardini, Francesca, Langer, Thomas, Laratta, Matteo, Casella, Giampaolo, Marsili, Maria, Stropeni, Serena, Cordolcini, Valentina, Crimella, Francesco, Santini, Alessandro, Greco, Massimiliano, Ferrari, Michele, Iapichino, Giacomo, Severgnini, Paolo, Maraggia, Davide, Gasberti, Dario, Motta, Alessandro, Coloretti, Irene, Busani, Stefano, Tosi, Martina, Gatto, Ilenia, Montalto, Carlo, Biondo, Alberto, Algamain, Ziad, Alaimo, Valentina, Tullo, Livio, Padovano, Francesco Paolo, Pizzilli, Giacinto, Cavalli, Irene, Simonte, Rachele, Valeri, Davide, DePascale, Gennaro, Carelli, Simone, Noseda, Valentina, Cimicchi, Giacomo, Ottonello, Gaia, Ghedin, Rossano, Giacalone, Francesco, Bove, Tiziana, Meroi, Francesco, Scapol, Sara, Pistidda, Laura, Muretti, Angela, Spadaro, Savino, Scaramuzzo, Gaetano, Ferraro, Gioconda, Gagliardi, Giuseppe, Sabbatini, Giovanni, Pezzi, Angelo, Sales, Gabriele, Montrucchio, Giorgia, Carsetti, Andrea, Longhini, Federico, Vargas, Maria, Calligaro, Plinio, Mariani, Ilaria, Zambelli, Vanessa, Noè, Beatrice, and Serra, Filippo

Published
2024
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16. Efficacy and adverse events profile of videolaryngoscopy in critically ill patients: subanalysis of the INTUBE study

Author

Anstey, Matthew, Colica, Sandra, Brewster, David, Simpson, Shannon, Regli, Adrian, O'Grady, Ross, Litton, Edward, Ferrier, Janet, Bartholdy, Roland, Tabah, Alexis, Bowen, David, Rowley, Rebecca, Gatward, Jonathan, Alonso, Julio, Varkey, Sneha, Palaniswamy, Vijayanand, Chimunda, Timothy, Reza, Syed T., Hossain, Mozaffer, Islam, Motiul, Hamid, Tarikul, Parotto, Matteo, Ajami, Samareh, Steel, Andrew, Del Sorbo, Lorenzo, Goffi, Alberto, Randall, Ian, Adhikari, Neill K.J., Mehesry, Tasneem H., Vera, Maria M., Bugedo, Guillermo, Labarca, Gonzalo, Silva, Monica, Ma, Wuhua, Li, Yongxing, Wu, Jiayan, Wu, Lun, Radivojević, Renata Curić, Matas, Marijana, Ivančan, Višnja, Pavlek, Mario, Mihaljević, Slobodan, Jumić, Aleksandra, Moguš, Mate, Tucić, Iva, Michalek, Pavel, Flaksa, Marek, Aguirre-Bermeo, Hernan, Tirape-Castro, Hugo, García Aguilera, Maria F., Montenegro, Diana Alvarez, Tutillo, Diego Morocho, Tutillo León, Jose A., Winiszewski, Hadrien, Piton, Gael, Aissaoui, Nadia, Augy, Jean-Loup, Champigneulle, Benoit, Zlotnik, Diane, Muller, Grégoire, Jacquier, Sophie, Hraiech, Sami, Guervilly, Christophe, Plantefeve, Gaetan, Contou, Damien, Ricard, Jean Damien, Besset, Sebastien, Colin, Gwenhael, Pouplet, Caroline, Mirouse, Adrien, Azoulay, Elie, Boissier, Florence, Frat, Jean-Pierre, Mercier, Emmanuelle, Salmon-Gandonnière, Charlotte, Lascarrou, Jean-Baptiste, Martin, Maelle, Ferre, Alexis, Legriel, Stephane, Bruel, Cedric, Philippard, Francois, Zarka, Jonathan, Chemouni, Frank, Hamzaoui, Olfa, Sztrymf, Benjamin, Brunin, Yannick, Pili-Floury, Sébastien, Constantin, Jean-Michel, Godet, Thomas, Maraffi, Tommaso, Dessap, Armand Mekontso, Jozwiak, Mathieu, Marin, Nathalie, Guitton, Christophe, Chudeau, Nicolas, Gros, Alexandre, Boyer, Alexandre, Papandreou, Eleni, Petsiou, Athanasia, Papanikolaou, Metaxia, Kyparissi, Aikaterini, Tileli, Maria, Makris, Alexandros, Tsiftsis, Dimitrios, El-Fellah, Nadia, Karametos, Ilias, Nakou, Evi, Chalkias, Athanasios, Arnaoutoglou, Eleni, Katsoulis, Panagiotis, Pouriki, Sofia, Vagdatli, Kyriaki, Dimitropoulou, Aikaterini, Kothekar, Amol, Baliga, Nishanth, Korula, Sara V., Philip, Sam, Singh, Lalit, Agrawal, Nipun, Jeswani, Deepak, Jeswani, Deepti, Jha, Simant, Singh, Nitesh, Bhattacharyya, Mahuya, Das, Amit, Kuragayala, Swarna D., Kesavarapu, Subba R., Shah, Bhagyesh, Kaushik, Shuchi, Sunil, Nilu, Gnanadurai, Kingsly, Singh, Atul K., Singh, Dinesh K., Khunteta, Sudhir, Gupta, Kulbhusahn, Sanyal, Rhik, Midya, Abhirup, Tyagi, Vijay N., Bendre, Prashant, Prashant, Kumar, Chaurasia, Satish, Mishra, Prasanna, Dash, Sampat, Sundrani, Omprakash, Lalwani, Jaya, Jain, Nikhilesh, Agrawal, Kehari, Ray, Banambar, Meher, Ranjan, Saravanabavan, Lakshmikanthcharan, Munusamy, Satheesh, Gupta, Manish, Ahmad, Meraj, Gopalakrishna, Kadarapura N., Suparna, Bharadwaj, Surath, Manimala R., Munta, Kartik, Jagiasi, Bharat, Srivastava, Anand, Sahu, Samir, Mrinal, Sircar, Kumar, Singh Sujeet, Shah, Mehul, Patel, Mayur, Bamane, Shrirang, Narkhede, Amit, Chawla, Rajesh, Chawla, Aakanksha, Maheshwarappa, Harish Mallapura, Manjunath, Ramya Ballekatte, Rahmani, Lua, Laffey, John G., Rona, Roberto, Benini, Annalisa, Russotto, Vincenzo, Rundo, Annalisa, Luzi, Annalisa, Esposito, Clelia, Nespoli, Moana R., Pradella, Andrea, Lungu, Ramona, Baccari, Laura, Chiumiento, Fernando, Mariano, Karim, Cotoia, Antonella, De Rosa, Silvia, Boni, Elisa, Palmese, Salvatore, Gammaldi, Renato, Spadaro, Savino, Santoro, Lida, Cracchiolo, Andrea N., Palma, Daniela M., Pinciroli, Riccardo, Giovannini, Ilaria, Calamai, Italo, Spina, Rosario, Cappellini, Iacopo, Tutino, Lorenzo, Bellissima, Agrippino, Maugeri, Jessica G., Riva, Ivano, Fabretti, Fabrizio, Brazzi, Luca, Sales, Gabriele, Montrucchio, Giorgia, Orsello, Alberto, Costamagna, Andrea, Canavosio, Federico G., Pelagalli, Lorella, Marcelli, Maria E., Cortegiani, Andrea, Tramarin, Jacopo, Musso, Stefania, Tarantino, Stefano, Di Giacinto, Ida, Licciardi, Anna L., Montini, Luca, De Pascale, Gennaro, Giacomucci, Angelo, Russo, Pierpaolo, Longhini, Federico, Garofalo, Eugenio, Ferluga, Massimo, Moro, Valeria, Cascella, Marco, Di Caprio, Barbara, Di Fenza, Raffaele, Nespoli, Francesca, Bassini, Ospedale E., Muttini, Stefano, Pezzi, Angelo, Elhadi, Muhammed, Ghula, Mohamed, Ahmed, Hazem Abdelkarem, Khaled, Ala, Elhadi, Ahmed, Alhadi, Abdulmueti, Mazlan, Mohd Z., Wan Hassan, Wan Mohd N., Hasan, Shahnaz, Jamaluddin, Muhamad F.H., Samat, Noryani Mohd, Ismail, Muhamad A., Alias, Anita, Hwa, Ngu Pei, Irtiza, Ismail Nahla, Khalidah, Hapiz, Kiok, Lee Chew, Nordin, Norbaniza Mohd, Wan Ismail, Wan N., Ali, Mohd N., Sánchez-Hurtado, Luis, Toledo-Salinas, Otoniel, Landaverde, Antonio, Sosa, Miguel A., Gonzalez, Mayra Martinez, Lopez Nava, Claudia L., San Juan Roman, Nandyelly, Gonzalez, Maria, Espinoza, Missael, González, Daira, Flores, Fernando, Pantoja Leal, Jesus N., Loza Gallardo, Luis R., Young, Paul, Mistry, Ravi, Browne, Alexander, Crone, Petra, Chandwani, Juhi, Hossein, Sazzad, Koul, Salman S., Aman, Rubina, Ali, Syed M., Akhtar, Shazia N., Jankowski, Milosz, Bielanski, Piotr, Mudyna, Wojciech, Franczyk, Pawel, Galkin, Piotr, Skowronski, Lukasz, Gaszynski, Tomasz, Piegat, Mariusz, Catorze, Nuno, Pinto, Marcia, Leonor, Tiago, Fernandes, Marco, Campos, Patricia, Aragão, Irene, Costa, Paulo F., Franco, Daniela G., Basto, Marta, Nogueira, Carla, Cunha, Rui P., Costa, Vasco, Lomivorotov, Vladimir, Nikitenko, Artem, Belsky, Vladislav, Furman, Mikhail, Magomedov, Marat, Baturova, Vera, Karelov, Alexey, Marova, Nadezhda, Almekhlafi, Ghaleb, Alghamdi, Adnan, Maseda, Emilio, Suarez de la Rica, Alejandro, Gonzalez, Jesus Flores, Ruiz, Miryam Pérez, Roca, Oriol, Santafe, Manel, Fernandez, Gemma Goma, Escudero-Acha, Patricia, González-Castro, Alejandro, Agvald-Öhman, Christina, Broman, Lina, Spangfors, Martin, Hannesdottir, Katrin, Persson, Elin, Rosell, Jon, Sperber, Jesper, Ohlsson, Annika, Von Seth, Magnus, Pedrotti, Niccolò, Wahlstrom, Carl, Meirik, Maria, Bandert, Anna, Krog, Ditte, Kuo, Lu-Cheng, Shin, Ming-Hann, Chien, Jung-Yien, Ku, Shih-Chi, Ruan, Sheng-Yuan, Huang, Chun-Kai, Yeh, Yu-Chang, Chao, Anne, Wang, Kuo-Chuan, Chiu, Ching-Tang, Lee, Chien-Chang, Chou, Nai-Kuan, Szakmany, Tamas, Jones, Benjamin, Jones, Laura, Della Torre, Valentina, Sinah, Ayush, Quayle, Alice, Cheetham, Olivia, Syed, Yadullah, Mensah, Kwabena, Edmunds, Christopher, Kaye, Callum T., Bauer, Philippe R., Odeyemi, Yewande E., Nates, Joseph, Laserna, Andres, Mosier, Jarrod, Hypes, Cameron, Gottesman, Eric, Mastroianni, Fiore, Fein, Daniel G., Zhao, Dawn, Fonseca Fuentes, Xavier E., Gallo de Moraes, Alice, Sandefur, Benjamin J., Khan, Akram, Matos, Dubier, Kaufman, David A., Lehr, Andrew, Bigatello, Luca, Bonney, Iwona, Lascarrou, Jean Baptiste, Tassistro, Elena, Antolini, Laura, Bauer, Philippe, Szułdrzyński, Konstanty, Camporota, Luigi, Putensen, Christian, Pelosi, Paolo, Sorbello, Massimiliano, Higgs, Andy, Greif, Robert, Grasselli, Giacomo, Valsecchi, Maria G., Fumagalli, Roberto, Foti, Giuseppe, Caironi, Pietro, Bellani, Giacomo, and Myatra, Sheila N.

Published
2023
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17. Resonant inelastic x-ray scattering of magnetic excitations under pressure

Author

Rossi, Matteo, Henriquet, Christian, Jacobs, Jeroen, Donnerer, Christian, Boseggia, Stefano, Al-Zein, Ali, Fumagalli, Roberto, Yao, Yi, Vale, James G., Hunter, Emily C., Perry, Robin S., Kantor, Innokenty, Garbarino, Gaston, Crichton, Wilson, Monaco, Giulio, McMorrow, Desmond F., Krisch, Michael, and Sala, Marco Moretti

Subjects
Condensed Matter - Strongly Correlated Electrons, Physics - Instrumentation and Detectors
Abstract

Resonant inelastic x-ray scattering (RIXS) is an extremely valuable tool for the study of elementary, including magnetic, excitations in matter. Latest developments of this technique mostly aimed at improving the energy resolution and performing polarization analysis of the scattered radiation, with a great impact on the interpretation and applicability of RIXS. Instead, this article focuses on the sample environment and presents a setup for high-pressure low-temperature RIXS measurements of low-energy excitations. The feasibility of these experiments is proved by probing the magnetic excitations of the bilayer iridate Sr$_3$Ir$_2$O$_7$ at pressures up to 12 GPa., Comment: 9 pages, 7 figures

Published
2019
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18. Determining the Electron-Phonon Coupling in Superconducting Cuprates by Resonant Inelastic X-ray Scattering: Methods and Results on Nd$_{1+x}$Ba$_{2-x}$Cu$_3$O$_{7-\delta}$

Author

Braicovich, Lucio, Rossi, Matteo, Fumagalli, Roberto, Peng, Yingying, Wang, Yan, Arpaia, Riccardo, Betto, Davide, De Luca, Gabriella M., Di Castro, Daniele, Kummer, Kurt, Sala, Marco Moretti, Pagetti, Mattia, Balestrino, Giuseppe, Brookes, Nicholas B., Salluzzo, Marco, Johnston, Steven, Brink, Jeroen van den, and Ghiringhelli, Giacomo

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

The coupling between lattice vibration quanta and valence electrons can induce charge density modulations and decisively influence the transport properties of materials, e.g. leading to conventional superconductivity. In high critical temperature superconductors, where electronic correlation is the main actor, the actual role of electron-phonon coupling (EPC) is being intensely debated theoretically and investigated experimentally. We present an in-depth study of how the EPC strength can be obtained directly from resonant inelastic x-ray scattering (RIXS) data through the theoretical approach derived by Ament et al. [EPL 95, 27008 (2011)]. The role of the model parameters (e.g. phonon energy $\omega_0$, intermediate state lifetime $1/\Gamma$, EPC matrix element $M$, and detuning energy $\Omega$) is thoroughly analyzed, providing general relations among them that can be used to make quantitative estimates of the dimensionless EPC $g = (M/\omega_0)^2$ without detailed microscopic modeling. We then apply these methods to very high resolution Cu $L_3$ edge RIXS spectra of three Nd$_{1+x}$Ba$_{2-x}$Cu$_3$O$_{7-\delta}$ films. For the insulating antiferromagnetic parent compound the value of $M$ as a function of the in-plane momentum transfer is obtained for Cu-O bond-stretching (breathing) and bond-bending (buckling) phonon branches. For the underdoped and the nearly optimally doped samples, the effects of Coulomb screening and of charge-density-wave correlations on $M$ are assessed. In light of the anticipated further improvements of the RIXS experimental resolution, this work provides a solid framework for an exhaustive investigation of the EPC in cuprates and other quantum materials., Comment: 21 pages, 16 figures

Published
2019
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19. Experimental Determination of Momentum-Resolved Electron-Phonon Coupling

Author

Rossi, Matteo, Arpaia, Riccardo, Fumagalli, Roberto, Sala, Marco Moretti, Betto, Davide, De Luca, Gabriella M., Kummer, Kurt, Brink, Jeroen van den, Salluzzo, Marco, Brookes, Nicholas B., Braicovich, Lucio, and Ghiringhelli, Giacomo

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

We provide a novel experimental method to quantitatively estimate the electron-phonon coupling and its momentum dependence from resonant inelastic x-ray scattering (RIXS) spectra based on the detuning of the incident photon energy away from an absorption resonance. We apply it to the cuprate parent compound NdBa$_2$Cu$_3$O$_6$ and find that the electronic coupling to the oxygen half-breathing phonon mode is strongest at the Brillouin zone boundary, where it amounts to $\sim 0.17$ eV, in agreement with previous studies. In principle, this method is applicable to any absorption resonance suitable for RIXS measurements and will help to define the contribution of lattice vibrations to the peculiar properties of quantum materials., Comment: 6 pages, 3 figures

Published
2019
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20. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

Author

Abrough, Fekri, Acharya, Subhash P, Amin, Pravin, Arabi, Yaseen, Aragao, Irene, Bauer, Philippe, Beduneau, Gaëtan, Beitler, Jeremy, Berkius, Johan, Bugedo, Guillermo, Camporota, Luigi, Cerny, Vladimir, Cho, Young-Jae, Clarkson, Kevin, Estenssoro, Elisa, Goligher, Ewan, Grasselli, Giacomo, Gritsan, Alexey, Hashemian, Seyed Mohammadreza, Hermans, Greet, Heunks, Leo M, Jovanovic, Bojan, Kurahashi, Kiyoyasu, Laake, Jon Henrik, Matamis, Dimitrios, Moerer, Onnen, Molnar, Zsolt, Ozyilmaz, Ezgi, Panka, Bernardo, Papali, Alfred, Peñuelas, Óscar, Perbet, Sébastien, Piquilloud, Lise, Qiu, Haibo, Razek, Assem Abdel, Rittayamai, Nuttapol, Roldan, Rollin, Serpa Neto, Ary, Szuldrzynski, Konstanty, Talmor, Daniel, Tomescu, Dana, Van Haren, Frank, Villagomez, Asisclo, Zeggwagh, Amine Ali, Abe, Toshikazu, Aboshady, Abdelrhman, Acampo-de Jong, Melanie, Acharya, Subhash, Adderley, Jane, Adiguzel, Nalan, Agrawal, Vijay Kumar, Aguilar, Gerardo, Aguirre, Gaston, Aguirre-Bermeo, Hernan, Ahlström, Björn, Akbas, Türkay, Akker, Mustafa, Al Sadeh, Ghamdan, Alamri, Sultan, Algaba, Angela, Ali, Muneeb, Aliberti, Anna, Allegue, Jose Manuel, Alvarez, Diana, Amador, Joaquin, Andersen, Finn H, Ansari, Sharique, Apichatbutr, Yutthana, Apostolopoulou, Olympia, Arellano, Daniel, Arica, Mestanza, Arikan, Huseyin, Arinaga, Koichi, Arnal, Jean-Michel, Asano, Kengo, Asín-Corrochano, Marta, Avalos Cabrera, Jesus Milagrito, Avila Fuentes, Silvia, Aydemir, Semih, Aygencel, Gulbin, Azevedo, Luciano, Bacakoglu, Feza, Badie, Julio, Baedorf Kassis, Elias, Bai, Gabriela, Balaraj, Govindan, Ballico, Bruno, Banner-Goodspeed, Valerie, Banwarie, Preveen, Barbieri, Rosella, Baronia, Arvind, Barrett, Jonathan, Barrot, Loïc, Barrueco-Francioni, Jesus Emilio, Barry, Jeffrey, Bawangade, Harshal, Beavis, Sarah, Beck, Eduardo, Beehre, Nina, Belenguer Muncharaz, Alberto, Bellani, Giacomo, Belliato, Mirko, Bellissima, Agrippino, Beltramelli, Rodrigo, Ben Souissi, Asma, Benitez-Cano, Adela, Benlamin, Mohamed, Benslama, Abdellatif, Bento, Luis, Benvenuti, Daniela, Bernabe, Laura, Bersten, Andrew, Berta, Giacomo, Bertini, Pietro, Bertram-Ralph, Elliot, Besbes, Mohamed, Bettini, Lisandro Roberto, Beuret, Pascal, Bewley, Jeremy, Bezzi, Marco, Bhakhtiani, Lakshay, Bhandary, Rakesh, Bhowmick, Kaushik, Bihari, Shailesh, Bissett, Bernie, Blythe, David, Bocher, Simon, Boedjawan, Narain, Bojanowski, Christine M, Boni, Elisa, Boraso, Sabrina, Borelli, Massimo, Borello, Silvina, Borislavova, Margarita, Bosma, Karen J, Bottiroli, Maurizio, Boyd, Owen, Bozbay, Suha, Briva, Arturo, Brochard, Laurent, Bruel, Cédric, Bruni, Andrea, Buehner, Ulrike, Bulpa, Pierre, Burt, Karen, Buscot, Mathieu, Buttera, Stefania, Cabrera, Jorge, Caccese, Roberta, Caironi, Pietro, Canchos Gutierrez, Ivan, Canedo, Nancy, Cani, Alma, Cappellini, Iacopo, Carazo, Jesus, Cardonnet, Luis Pablo, Carpio, David, Carriedo, Demetrio, Carrillo, Ramón, Carvalho, João, Caser, Eliana, Castelli, Antonio, Castillo Quintero, Manuel, Castro, Heloisa, Catorze, Nuno, Cengiz, Melike, Cereijo, Enrique, Ceunen, Helga, Chaintoutis, Christos, Chang, Youjin, Chaparro, Gustavogcha, Chapman, Carmel, Chau, Simon, Chavez, Cecilia Eugenia, Chelazzi, Cosimo, Chelly, Jonathan, Chemouni, Frank, Chen, Kai, Chena, Ariel, Chiarandini, Paolo, Chilton, Phil, Chiumello, Davide, Chou-Lie, Yvette, Chudeau, Nicolas, Cinel, Ismail, Cinnella, Gilda, Clark, Michele, Clark, Thomas, Clementi, Stefano, Coaguila, Luis, Codecido, Alexis Jaspe, Collins, Amy, Colombo, Riccardo, Conde, Juan, Consales, Guglielmo, Cook, Tim, Coppadoro, Andrea, Cornejo, Rodrigo, Cortegiani, Andrea, Coxo, Cristina, Cracchiolo, Andrea Neville, Crespo Ramirez, Mónica, Crova, Philippe, Cruz, José, Cubattoli, Lucia, Çukurova, Zafer, Curto, Francesco, Czempik, Piotr, D'Andrea, Rocco, da Silva Ramos, Fernando, Dangers, Laurence, Danguy des Déserts, Marc, Danin, Pierre-Eric, Dantas, Fabianne, Daubin, Cédric, Dawei, Wu, de Haro, Candelaria, de Jesus Montelongo, Felipe, De Mendoza, Diego, de Pablo, Raúl, De Pascale, Gennaro, De Rosa, Silvia, Decavèle, Maxens, Declercq, Pierre-Louis, Deicas, Alberto, del Carmen Campos Moreno, María, Dellamonica, Jean, Delmas, Benjamin, Demirkiran, Oktay, Demirkiran, Hilmi, Dendane, Tarek, di Mussi, Rossella, Diakaki, Chrysi, Diaz, Anatilde, Diaz, Willy, Dikmen, Yalim, Dimoula, Aikaterini, Doble, Patricia, Doha, Nagwa, Domingos, Guilherme, Dres, Martin, Dries, David, Duggal, Abhijit, Duke, Graeme, Dunts, Pavel, Dybwik, Knut, Dykyy, Maksym, Eckert, Philippe, Efe, Serdar, Elatrous, Souheil, Elay, Gülseren, Elmaryul, Abubaker S, Elsaadany, Mohamed, Elsayed, Hany, Elsayed, Samar, Emery, Malo, Ena, Sébastien, Eng, Kevin, Englert, Joshua A, Erdogan, Elif, Ergin Ozcan, Perihan, Eroglu, Ege, Escobar, Miguel, Esen, Figen, Esen Tekeli, Arzu, Esquivel, Alejandro, Esquivel Gallegos, Helbert, Ezzouine, Hanane, Facchini, Alberto, Faheem, Mohammad, Fanelli, Vito, Farina, Maria Fernanda, Fartoukh, Muriel, Fehrle, Lutz, Feng, Feng, Feng, Yufeng, Fernandez, Irene, Fernandez, Borja, Fernandez-Rodriguez, Maria Lorena, Ferrando, Carlos, Ferreira da Silva, Maria João, Ferreruela, Mireia, Ferrier, Janet, Flamm Zamorano, Matias Jesús, Flood, Laura, Floris, Leda, Fluckiger, Martin, Forteza, Catalina, Fortunato, Antonella, Frans, Eric, Frattari, Antonella, Fredes, Sebastian, Frenzel, Tim, Fumagalli, Roberto, Furche, Mariano Andres, Fusari, Maurizio, Fysh, Edward, Galeas-Lopez, Juan Luis, Galerneau, Louis-Marie, Garcia, Analía, Garcia, María Fernanda, Garcia, Elisabet, Garcia Olivares, Pablo, Garlicki, Jaroslaw, Garnero, Aude, Garofalo, Eugenio, Gautam, Prabha, Gazenkampf, Andrey, Gelinotte, Stéphanie, Gelormini, Domenico, Ghrenassia, Etienne, Giacomucci, Angelo, Giannoni, Robert, Gigante, Andrea, Glober, Nancy, Gnesin, Paolo, Gollo, Yari, Gomaa, Dina, Gomero Paredes, Rosita, Gomes, Rui, Gomez, Raúl Alejandro, Gomez, Oscar, Gomez, Aroa, Gondim, Louise, Gonzalez, Manuel, Gonzalez, Isabel, Gonzalez-Castro, Alejandro, Gordillo Romero, Orlando, Gordo, Federico, Gouin, Philippe, Graf Santos, Jerónimo, Grainne, Rooney, Grando, Matilde, Granov Grabovica, Sanja, Grasso, Salvatore, Grasso, Rinaldo, Grimmer, Lisa, Grissom, Colin, Gu, Qing, Guan, Xiang-Dong, Guarracino, Fabio, Guasch, Neus, Guatteri, Luca, Gueret, Renaud, Guérin, Claude, Guerot, Emmanuel, Guitard, Pierre-Gildas, Gül, Fethi, Gumus, Ayca, Gurjar, Mohan, Gutierrez, Patricia, Hachimi, Abdelhamid, Hadzibegovic, Adi, Hagan, Samantha, Hammel, Clare, Han Song, Joo, Hanlon, Gabrielle, Heines, Serge, Henriksson, Johanna, Herbrecht, Jean-Etienne, Heredia Orbegoso, Gabriel Omar, Hermon, Andrew, Hernandez, Rosana, Hernandez, Carmen, Herrera, Luis, Herrera-Gutierrez, Manuel, Heunks, Leo, Hidalgo, Juan, Hill, Dianne, Holmquist, Dagmar, Homez, Marcela, Hongtao, Xia, Hormis, Anil, Horner, Daniel, Hornos, M Carmen, Hou, Meihong, House, Stacy, Housni, Brahim, Hugill, Keith, Humphreys, Sally, Humbert, Louis, Hunter, Stephanie, Hwa Young, Lee, Iezzi, Nicolas, Ilutovich, Santiago, Inal, Volkan, Innes, Richard, Ioannides, Panagiotis, Iotti, Giorgio Antonio, Ippolito, Mariachiara, Irie, Hiromasa, Iriyama, Hiroki, Itagaki, Taiga, Izura, Javier, Izza, Santiago, Jabeen, Rakhshanda, Jamaati, Hamidreza, Jamadarkhana, Sunil, Jamoussi, Amira, Jankowski, Milosz, Jaramillo, Luis Alberto, Jeon, Kyeongman, Jeong Lee, Seok, Jeswani, Deepak, Jha, Simant, Jiang, Liangyan, Jing, Chen, Jochmans, Sébastien, Johnstad, Bror Anders, Jongmin, Lee, Joret, Aurélie, Junhasavasdikul, Detajin, Jurado, Maria Teresa, Kam, Elisa, Kamohara, Hidenobu, Kane, Caroline, Kara, Iskender, Karakurt, Sait, Karnjanarachata, Cherdkiat, Kataoka, Jun, Katayama, Shinshu, Kaushik, Shuchi, Kelebek Girgin, Nermin, Kerr, Kathryn, Kerslake, Ian, Khairnar, Prakash, Khalid, Abidi, Khan, Akram, Khanna, Ashish K, Khorasanee, Reza, Kienhorst, Dieneke, Kirakli, Cenk, Knafelj, Rihard, Kol, Mark Kol, Kongpolprom, Napplika, Kopitko, Csaba, Korkmaz Ekren, Pervin, Kubisz-Pudelko, Agnieszka, Kulcsar, Zoltan, Kumasawa, Junji, Kuriyama, Akira, Kutchak, Fernanda, Labarca, Eduardo, Labat, Françoise, Laborda, César, Laca Barrera, Manuel Alberto, Lagache, Laurie, Landaverde Lopez, Antonio, Lanspa, Michael, Lascari, Valeria, Le Meur, Matthieu, Lee, Su Hwan, Lee, Young Ju, Lee, Jinwoo, Lee, Won-Yeon, Lee, Jarone, Legernaes, Terje, Leiner, Tamaas, Lemiale, Virginie, Leonor, Tiago, Lepper, Philipp M, Li, Dahuan, Li, Hongbin, Li, Oleg, Lima, Ana Raquel, Lind, Dan, Litton, Edward, Liu, Ning, Liu, Ling, Liu, Jialin, Llitjos, Jean-François, Llorente, Beatriz, Lopez, Rodolfo, Lopez, Claudia Elizabeth, Lopez Nava, Claudia, Lovazzano, Pablo, Lu, Min, Lucchese, Francesca, Lugano, Manuela, Lugo Goytia, Gustavo, Luo, Hua, Lynch, Ceri, Macheda, Sebastiano, Madrigal Robles, Victor Hugo, Maggiore, Salvatore Maurizio, Magret Iglesias, Mònica, Malaga, Peter, Mallapura Maheswarappa, Harish, Malpartida, Guillermo, Malyarchikov, Andrey, Mansson, Helena, Manzano, Anaid, Marey, Ismael, Marin, Nathalie, Marin, Maria del Carmen, Markman, Eliana, Martin, Felix, Martin, Alex, Martin Dal Gesso, Cristina, Martinez, Felipe, Martínez-Fidalgo, Conchita, Martin-Loeches, Ignacio, Mas, Arantxa, Masaaki, Sakuraya, Maseda, Emilio, Massa, Eleni, Mattsson, Anna, Maugeri, Jessica, McCredie, Victoria, McCullough, James, McGuinness, Shay, McKown, Andrew, Medve, László, Mei, Chengqing, Mellado Artigas, Ricard, Mendes, Vitor, Mervat, Mohamed Khalaf Ebraheim, Michaux, Isabelle, Mikhaeil, Michael, Milagros, Olga, Milet, Igor, Millan, Maria Teresa, Minwei, Zhang, Mirabella, Lucia, Mishra, Sanghamitra, Mistraletti, Giovanni, Mochizuki, Katsunori, Moghal, Arif, Mojoli, Francesco, Molin, Alexandre, Montiel, Raquel, Montini, Luca, Monza, Gianmario, Mora Aznar, Maria, Morakul, Sunthiti, Morales, Maria, Moreno Torres, Daniel, Morocho Tutillo, Diego Rolando, Motherway, Catherine, Mouhssine, Doumiri, Mouloudi, Eleni, Muñoz, Tapia, Munoz de Cabo, Carlos, Mustafa, Mohamed, Muthuchellappan, Radhakrishnan, Muthukrishnan, Muraleekrishnan, Muttini, Stefano, Nagata, Isao, Nahar, Dick, Nakanishi, Misuzu, Nakayama, Izumi, Namendys-Silva, Silvio Antonio, Nanchal, Rahul, Nandakumar, Sivakumar, Nasi, Alessandra, Nasir, Kamal, Navalesi, Paolo, Naz Aslam, Tayyba, Nga Phan, Thuy, Nichol, Alistair, Niiyama, Shuhei, Nikolakopoulou, Sofia, Nikolic, Elena, Nitta, Kenichi, Noc, Marko, Nonas, Stephanie, Nseir, Saad, Nur Soyturk, Ayse, Obata, Yukako, Oeckler, Richard, Oguchi, Moe, Ohshimo, Shinichiro, Oikonomou, Marina, Ojados, Agueda, Oliveira, Maria Teresa, Oliveira Filho, Wilson, Oliveri, Carlo, Olmos, Aitor, Omura, Kazuya, Orlandi, Maria Cristina, Orsenigo, Francesca, Ortiz-Ruiz De Gordoa, Laura, Ota, Kei, Ovalle Olmos, Rainier, Öveges, Nándo, Oziemski, Peter, Ozkan Kuscu, Ozlem, Pachas Alvarado, Fernando, Pagella, Gonzalo, Palaniswamy, Vijayanand, Palazon Sanchez, Eugenio Luis, Palmese, Salvatore, Pan, Guojun, Pan, Wensen, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Parekh, Ameet, Parke, Rachael, Parrilla, Francisco J, Parrilla, Dácil, Pasha, Taha, Pasin, Laura, Patão, Luis, Patel, Mayur, Patel, Grisma, Pati, Basanta Kumar, Patil, Jayaprakash, Pattnaik, Saroj, Paul, Daniel, Pavesi, Maurizio, Pavlotsky, Vanesa Alejandra, Paz, Graciela, Paz, Enrique, Pecci, Elisabetta, Pellegrini, Carlos, Peña Padilla, Andrea Gabriela, Perchiazzi, Gaetano, Pereira, Tiago, Pereira, Vera, Perez, Manuel, Perez Calvo, Cesar, Perez Cheng, Meisy, Perez Maita, Ronald, Pérez-Araos, Rodrigo, Perez-Teran, Purificación, Perez-Torres, David, Perkins, Gavin, Persona, Paolo, Petnak, Tananchai, Petrova, Marina, Pham, Tai, Philippart, François, Picetti, Edoardo, Pierucci, Elisabetta, Piervincenzi, Edoardo, Pinciroli, Riccardo, Pintado, Maria-Consuelo, Piraino, Thomas, Piras, Stephanie, Piras, Claudio, Pirompanich, Pattarin, Pisani, Luigi, Platas, Enrique, Plotnikow, Gustavo, Porras, Willy, Porta, Virginia, Portilla, Mariana, Portugal, José, Povoa, Pedro, Prat, Gwenael, Pratto, Romina, Preda, Gabriel, Prieto, Isidro, Prol-Silva, Estefania, Pugh, Richard, Qi, Yupeng, Qian, Chuanyun, Qin, Tiehe, Qu, Hongping, Quintana, Teobaldo, Quispe Sierra, Rosari, Quispe Soto, Rocio, Rabbani, Raihan, Rabee, Mohamed, Rabie, Ahmed, Rahe Pereira, Maria Augusta, Rai, Ashish, Raj Ashok, Sundar, Rajab, Mostafa, Ramdhani, Navin, Ramey, Elizabeth, Ranieri, Marco, Rathod, Darshana, Ray, Banambar, Redwanul Huq, Shihan Mahmud, Regli, Adrian, Reina, Rosa, Resano Sarmiento, Natalia, Reynaud, Faustine, Rialp, Gemma, Ricart, Pilar, Rice, Todd, Richardson, Angus, Rieder, Marcelo, Rinket, Martin, Rios, Fernando, Risso Vazquez, Alejandro, Riva, Ivano, Rivette, Monaly, Roca, Oriol, Roche-Campo, Ferran, Rodriguez, Covadonga, Rodriguez, Gabriel, Rodriguez Gonzalez, Daniel, Rodriguez Tucto, Xandra Yanina, Rogers, Angela, Romano, María Elena, Rørtveit, Linda, Rose, Alastair, Roux, Damien, Rouze, Anahita, Rubatto Birri, Paolo Nahuel, Ruilan, Wang, Ruiz Robledo, Aldana, Ruiz-Aguilar, Antonio Luis, Sadahiro, Tomohito, Saez, Ignacio, Sagardia, Judith, Saha, Rajnish, Saha, Rohit, Saiphoklang, Narongkorn, Saito, Shigeki, Salem, Maie, Sales, Gabriele, Salgado, Patricia, Samavedam, Srinivas, Sami Mebazaa, Mhamed, Samuelsson, Line, San Juan Roman, Nandyelly, Sanchez, Patricia, Sanchez-Ballesteros, Jesus, Sandoval, Yazcitk, Sani, Emanuele, Santos, Martin, Santos, Carla, Sanui, Masamitsu, Saravanabavan, Lakshmikanthcharan, Sari, Sema, Sarkany, Agnes, Sauneuf, Bertrand, Savioli, Monica, Sazak, Hilal, Scano, Riccardo, Schneider, Francis, Schortgen, Frédérique, Schultz, Marcus J, Schwarz, Gabriele Leonie, Seçkin Yücesoy, Faruk, Seely, Andrew, Seiler, Frederik, Seker Tekdos, Yasemin, Seok Chan, Kim, Serano, Luca, Serednicki, Wojciech, Setten, Mariano, Shah, Asim, Shah, Bhagyesh, Shang, You, Shanmugasundaram, Pradeep, Shapovalov, Konstantin, Shebl, Eman, Shiga, Takuya, Shime, Nobuaki, Shin, Phil, Short, Jack, Shuhua, Chen, Siddiqui, Sughrat, Silesky Jimenez, Juan Ignacio, Silva, Daniel, Silva Sales, Betania, Simons, Koen, Sjøbø, Brit Ågot, Slessor, David, Smiechowicz, Jakub, Smischney, Nathan, Smith, Paul, Smith, Tim, Smith, Mark, Snape, Sarah, Snyman, Lindi, Soetens, Filiep, Sook Hong, Kyung, Sosa Medellin, Miguel Ángel, Soto, Giovanna, Souloy, Xavier, Sousa, Elsa, Sovatzis, Stefania, Sozutek, Didem, Spadaro, Savino, Spagnoli, Marco, Spångfors, Martin, Spittle, Nick, Spivey, Mike, Stapleton, Andrew, Stefanovic, Branislava, Stephenson, Lorraine, Stevenson, Elizabeth, Strand, Kristian, Strano, Maria Teresa, Straus, Slavenka, Sun, Chenliang, Sun, Rongqing, Sundaram, Venkat, SunPark, Tai, Surlemont, Elisabeth, Sutherasan, Yuda, Szabo, Zsuzsanna, Tainter, Christopher, Takaba, Akihiro, Tallott, Mandy, Tamasato, Tamasato, Tang, Zhanhong, Tangsujaritvijit, Viratch, Taniguchi, Leandro, Taniguchi, Daisuke, Tarantino, Fabio, Teerapuncharoen, Krittika, Temprano, Susana, Terragni, Pierpaolo, Terzi, Nicolas, Thakur, Anand, Theerawit, Pongdhep, Thille, Arnaud W, Thomas, Matt, Thungtitigul, Poungrat, Thyrault, Martial, Tilouch, Nejla, Timenetsky, Karina, Tirapu, Juna, Todeschini, Manuel, Tomas, Roser, Tomaszewski, Christian, Tonetti, Tommaso, Tonnelier, Alexandre, Trinder, John, Trongtrakul, Konlawij, Truwit, Jonathon, Tsuei, Betty, Tulaimat, Aiman, Turan, Sema, Turkoglu, Melda, Tyagi, Sanjeev, Ubeda, Alejandro, Vagginelli, Federica, Valenti, María Florencia, Vallverdu, Imma, Van Axel, Alisha, van den Hul, Ingrid, van der Hoeven, Hans, Van Der Meer, Nardo, Vanhoof, Marc, Vargas-Ordoñez, Mónica, Vaschetto, Rosanna, Vascotto, Ettore, Vatsik, Maria, Vaz, Ana, Vazquez-Sanchez, Antonia, Ventura, Sara, Vermeijden, Jan Wytze, Vidal, Anxela, Vieira, Jocyelle, Vilela Costa Pinto, Bruno, Villagra, Ana, Villegas Succar, Cristina, Vinorum, Ole Georg, Vitale, Giovanni, Vj, Ramesh, Vochin, Ana, Voiriot, Guillaume, Volta, Carlo Alberto, von Seth, Magnus, Wajdi, Maazouzi, Walsh, Don, Wang, Shouhong, Wardi, Gabriel, Ween-Velken, Nils Christian, Wei, Bi-Lin, Weller, Dolf, Welsh, Deborah, Welters, Ingeborg, Wert, Michael, Whiteley, Simon, Wilby, Elizabeth, Williams, Erin, Williams, Karen, Wilson, Antoinette, Wojtas, Jadwiga, Won Huh, Jin, Wrathall, David, Wright, Christopher, Wu, Jian-Feng, Xi, Guo, Xing, Zheng-Jiang, Xu, Hongyang, Yamamoto, Kotaro, Yan, Jie, Yáñez, Julio, Yang, Xiaobo, Yates, Elliot, Yazicioglu Mocin, Ozlem, Ye, Zhenglong, Yildirim, Fatma, Yoshida, Norifumi, Yoshido, Hector Higo Leon, Young Lee, Bo, Yu, Rongguo, Yu, Gong, Yu, Tao, Yuan, Boyun, Yuangtrakul, Nadwipa, Yumoto, Tetsuya, Yun, Xie, Zakalik, Graciela, Zaki, Ahmad, Zalba-Etayo, Begoña, Zambon, Massimo, Zang, Bin, Zani, Gianluca, Zarka, Jonathan, Zerbi, Simone Maria, Zerman, Avsar, Zetterquist, Harald, Zhang, Jiuzhi, Zhang, Hongwen, Zhang, Wei, Zhang, Guoxiu, Zhang, Weixin, Zhao, Hongsheng, Zheng, Jia, Zhu, Bin, Zumaran, Ronald, Pham, Tài, Madotto, Fabiana, Goligher, Ewan C, Mancebo, Jordi, Peñuelas, Oscar, Pesenti, Antonio, Wunsch, Hannah, van Haren, Frank, and Laffey, John G

Published
2023
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24. SARS-CoV-2 breakthrough infections in vaccinated individuals requiring ventilatory support for severe acute respiratory failure

Author

Finazzi, Stefano, Perego, Matilde, Tricella, Giovanni, Poole, Daniele, Ranieri, V. Marco, Rizzo, Caterina, and Fumagalli, Roberto

Subjects
Vaccination, Medical colleges, Acute respiratory distress syndrome, Health care industry
Abstract

Author(s): Stefano Finazzi [sup.1] [sup.2], Matilde Perego [sup.1] [sup.2], Giovanni Tricella [sup.1], Daniele Poole [sup.2] [sup.3], V. Marco Ranieri [sup.4], Caterina Rizzo [sup.1], Roberto Fumagalli [sup.1], Jorio Antonella [sup.1], Petrucci [...]

Published
2023
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32. Quantitative Computed Tomography and Response to Pronation in COVID-19 ARDS.

Author

Zadek, Francesco, Berta, Luca, Zorzi, Giulia, Ubiali, Stefania, Bonaiti, Amos, Tundo, Giulia, Brunoni, Beatrice, Marrazzo, Francesco, Giudici, Riccardo, Rossi, Anna, Rizzetto, Francesco, Bernasconi, Davide Paolo, Vanzulli, Angelo, Colombo, Paola Enrica, Fumagalli, Roberto, Torresin, Alberto, and Langer, Thomas

Subjects
BLOOD gases analysis, ADULT respiratory distress syndrome, PATIENTS, PULMONARY gas exchange, T-test (Statistics), COMPUTED tomography, LYING down position, SCIENTIFIC observation, KRUSKAL-Wallis Test, FISHER exact test, RETROSPECTIVE studies, MANN Whitney U Test, CHI-squared test, DESCRIPTIVE statistics, MEDICAL records, ACQUISITION of data, ANALYSIS of variance, PATIENT positioning, COVID-19, MECHANICAL ventilators, REGRESSION analysis
Abstract

BACKGROUND: The use of prone position (PP) has been widespread during the COVID-19 pandemic. Whereas it has demonstrated benefits, including improved oxygenation and lung aeration, the factors influencing the response in terms of gas exchange to PP remain unclear. In particular, the association between baseline quantitative computed tomography (CT) scan results and gas exchange response to PP in invasively ventilated subjects with COVID-19 ARDS is unknown. The present study aimed to compare baseline quantitative CT results between subjects responding to PP in terms of oxygenation or CO2 clearance and those who did not. METHODS: This was a single-center, retrospective observational study including critically ill, invasively ventilated subjects with COVID-19-related ARDS admitted to the ICUs of Niguarda Hospital between March 2020-November 2021. Blood gas samples were collected before and after PP. Subjects in whom the PaO2 /FIO2 increase was ≥ 20 mm Hg after PP were defined as oxygen responders. CO2 responders were defined when the ventilatory ratio (VR) decreased during PP. Automated quantitative CT analyses were performed to obtain tissue mass and density of the lungs. RESULTS: One hundred twenty-five subjects were enrolled, of which 116 (93%) were O2 responders and 51 (41%) CO2 responders. No difference in quantitative CT characteristics and oxygen were observed between responders and non-responders (tissue mass 1,532 ± 396 g vs 1,654 ± 304 g, P = .28; density -544 ± 109 HU vs -562 ± 58 HU P = .42). Similar findings were observed when dividing the population according to CO2 response (tissue mass 1,551 ± 412 g vs 1,534 ± 377 g, P = .89; density -545 ± 123 HU vs -546 ± 94 HU, P = .99). CONCLUSIONS: Most subjects with COVID-19-related ARDS improved their oxygenation at the first pronation cycle. The study suggests that baseline quantitative CT scan data were not associated with the response to PP in oxygenation or CO2 in mechanically ventilated subjects with COVID-19-related ARDS. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Quantitative CT scan and response to pronation in COVID-19 ARDS

Author

Zadek, Francesco, primary, Berta, Luca, additional, Zorzi, Giulia, additional, Ubiali, Stefania, additional, Bonaiuti, Amos, additional, Tundo, Giulia, additional, Brunoni, Beatrice, additional, Marrazzo, Francesco, additional, Giudici, Riccardo, additional, Rossi, Anna, additional, Rizzetto, Francesco, additional, Bernasconi, Davide Paolo, additional, Vanzulli, Angelo, additional, Colombo, Paola Enrica, additional, Fumagalli, Roberto, additional, Torresin, Alberto, additional, and Langer, Thomas, additional

Published
2024
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38. Oxygen-Sparing Anesthesia with Electrically Controlled Ventilators: A Bench Study with Implications for Clinical Practice and Resource Management

Author

Torrano, V, Zadek, F, Abbiati, G, Deli, C, Fumagalli, R, Langer, T, Torrano, Vito, Zadek, Francesco, Giacomo, Abbiati, Deli, Chiara, Fumagalli, Roberto, Langer, Thomas, Torrano, V, Zadek, F, Abbiati, G, Deli, C, Fumagalli, R, Langer, T, Torrano, Vito, Zadek, Francesco, Giacomo, Abbiati, Deli, Chiara, Fumagalli, Roberto, and Langer, Thomas

Published
2024

39. Successful Versus Failed Transition From Controlled Ventilation to Pressure Support Ventilation in COVID-19 Patients: A Retrospective Cohort Study

Author

Polo Friz, M, Rezoagli, E, Safaee Fakhr, B, Florio, G, Carlesso, E, Giudici, R, Forlini, C, Tardini, F, Langer, T, Laratta, M, Casella, G, Forastieri Molinari, A, Protti, A, Cecconi, M, Cabrini, L, Biagioni, E, Berselli, A, Mirabella, L, Tonetti, T, De Robertis, E, Grieco, D, Antonelli, M, Citerio, G, Fumagalli, R, Foti, G, Zanella, A, Grasselli, G, Bellani, G, Polo Friz, Melisa, Rezoagli, Emanuele, Safaee Fakhr, Bijan, Florio, Gaetano, Carlesso, Eleonora, Giudici, Riccardo, Forlini, Clarissa, Tardini, Francesca, Langer, Thomas, Laratta, Matteo, Casella, Giampaolo, Forastieri Molinari, Andrea, Protti, Alessandro, Cecconi, Maurizio, Cabrini, Luca, Biagioni, Emanuela, Berselli, Angela, Mirabella, Lucia, Tonetti, Tommaso, De Robertis, Edoardo, Grieco, Domenico Luca, Antonelli, Massimo, Citerio, Giuseppe, Fumagalli, Roberto, Foti, Giuseppe, Zanella, Alberto, Grasselli, Giacomo, Bellani, Giacomo, Polo Friz, M, Rezoagli, E, Safaee Fakhr, B, Florio, G, Carlesso, E, Giudici, R, Forlini, C, Tardini, F, Langer, T, Laratta, M, Casella, G, Forastieri Molinari, A, Protti, A, Cecconi, M, Cabrini, L, Biagioni, E, Berselli, A, Mirabella, L, Tonetti, T, De Robertis, E, Grieco, D, Antonelli, M, Citerio, G, Fumagalli, R, Foti, G, Zanella, A, Grasselli, G, Bellani, G, Polo Friz, Melisa, Rezoagli, Emanuele, Safaee Fakhr, Bijan, Florio, Gaetano, Carlesso, Eleonora, Giudici, Riccardo, Forlini, Clarissa, Tardini, Francesca, Langer, Thomas, Laratta, Matteo, Casella, Giampaolo, Forastieri Molinari, Andrea, Protti, Alessandro, Cecconi, Maurizio, Cabrini, Luca, Biagioni, Emanuela, Berselli, Angela, Mirabella, Lucia, Tonetti, Tommaso, De Robertis, Edoardo, Grieco, Domenico Luca, Antonelli, Massimo, Citerio, Giuseppe, Fumagalli, Roberto, Foti, Giuseppe, Zanella, Alberto, Grasselli, Giacomo, and Bellani, Giacomo

Abstract

OBJECTIVES: In patients with COVID-19 respiratory failure, controlled mechanical ventilation (CMV) is often necessary during the acute phases of the disease. Weaning from CMV to pressure support ventilation (PSV) is a key objective when the patient’s respiratory functions improve. Limited evidence exists regarding the factors predicting a successful transition to PSV and its impact on patient outcomes. DESIGN: Retrospective observational cohort study. SETTING: Twenty-four Italian ICUs from February 2020 to May 2020. PATIENTS: Mechanically ventilated ICU patients with COVID-19-induced respiratory failure. INTERVENTION: The transition period from CMV to PSV was evaluated. We defined it as “failure of assisted breathing” if the patient returned to CMV within the first 72 hours. MEASUREMENTS AND MAIN RESULTS: Of 1260 ICU patients screened, 514 were included. Three hundred fifty-seven patients successfully made the transition to PSV, while 157 failed. Pao2/Fio2 ratio before the transition emerged as an independent predictor of a successful shift (odds ratio 1.00; 95% CI, 0.99–1.00; p = 0.003). Patients in the success group displayed a better trend in Pao2/Fio2, Paco2, plateau and peak pressure, and pH level. Subjects in the failure group exhibited higher ICU mortality (hazard ratio 2.08; 95% CI, 1.42–3.06; p < 0.001), an extended ICU length of stay (successful vs. failure 21 ± 14 vs. 27 ± 17 d; p < 0.001) and a longer duration of mechanical ventilation (19 ± 18 vs. 24 ± 17 d, p = 0.04). CONCLUSIONS: Our study emphasizes that the Pao2/Fio2 ratio was the sole independent factor associated with a failed transition from CMV to PSV. The unsuccessful transition was associated with worse outcomes.

Published
2024

40. Gas Humidification During Helmet Continuous Positive Airway Pressure: A Crossover Randomized Physiologic Study in Healthy Subjects

Author

Ambrosetti, L, Giani, M, Rezoagli, E, Fiorillo, C, Vitale, D, Giacchè, D, Ravasio, G, Fumagalli, R, Foti, G, Lucchini, A, Ambrosetti, Lorenzo, Giani, Marco, Rezoagli, Emanuele, Fiorillo, Chiara, Vitale, Daniela, Giacchè, Damiano, Ravasio, Giambattista, Fumagalli, Roberto, Foti, Giuseppe, Lucchini, Alberto, Ambrosetti, L, Giani, M, Rezoagli, E, Fiorillo, C, Vitale, D, Giacchè, D, Ravasio, G, Fumagalli, R, Foti, G, Lucchini, A, Ambrosetti, Lorenzo, Giani, Marco, Rezoagli, Emanuele, Fiorillo, Chiara, Vitale, Daniela, Giacchè, Damiano, Ravasio, Giambattista, Fumagalli, Roberto, Foti, Giuseppe, and Lucchini, Alberto

Abstract

Background In the last decades, the use of the helmet interface to deliver noninvasive respiratory support has steadily increased. When delivering oxygen therapy, conditioning of inspired gas is mandatory, as the water content of medical gas is neglectable. To minimize the risk of airway damage, it is recommended to achieve an absolute humidity greater than 10 mg H2O/L. The primary aim of the study was to assess the performance of 3 different heated humidifiers to condition gas during helmet continuous positive airway pressure and to compare them with a setting without active humidification. Methods We performed a crossover randomized physiological study in healthy volunteers. Absolute humidity, relative humidity, and temperature were measured during 4 steps (no humidification and the 3 heated humidifiers, performed in a randomized order) and at 3 time points (after 1, 5, and 10 minutes). Results Eight subjects participated to the study. Without active humidification, absolute humidity was constantly below the recommended level. All humidifiers conditioned the inspired gases to an average absolute humidity greater than 10 mg H2O/L. Overall, the best performance, in terms of absolute humidity, was obtained with H900 (19.74 ± 0.50 mg H2O/L), followed by TurbH2O (-6.82 mg H2O/L vs H900; 95% confidence interval, -8.49 to -5.14; P <.05) and F&P 810 (-9.03 mg H2O/L vs H900; 95% confidence interval, -10.70 to -7.35; P <.05). Conclusions Active humidification is required to achieve adequate conditioning of inspired gas during helmet continuous positive airway pressure. The choice between different humidifiers available on the market should be made according to the local needs and expertise.

Published
2024

41. Uncomplicated calcium-citrate anticoagulation during continuous renal replacement therapy in two other patients with metformin accumulation

Author

Brunoni, B, Zadek, F, Protti, A, Cecconi, M, Fumagalli, R, Langer, T, Brunoni, Beatrice, Zadek, Francesco, Protti, Alessandro, Cecconi, Maurizio, Fumagalli, Roberto, Langer, Thomas, Brunoni, B, Zadek, F, Protti, A, Cecconi, M, Fumagalli, R, Langer, T, Brunoni, Beatrice, Zadek, Francesco, Protti, Alessandro, Cecconi, Maurizio, Fumagalli, Roberto, and Langer, Thomas

Published
2024

42. Quantitative CT scan and response to pronation in COVID-19 ARDS

Author

Zadek, F, Berta, L, Zorzi, G, Ubiali, S, Bonaiuti, A, Tundo, G, Brunoni, B, Marrazzo, F, Giudici, R, Rossi, A, Rizzetto, F, Bernasconi, D, Vanzulli, A, Colombo, P, Fumagalli, R, Torresin, A, Langer, T, Zadek, Francesco, Berta, Luca, Zorzi, Giulia, Ubiali, Stefania, Bonaiuti, Amos, Tundo, Giulia, Brunoni, Beatrice, Marrazzo, Francesco, Giudici, Riccardo, Rossi, Anna, Rizzetto, Francesco, Bernasconi, Davide Paolo, Vanzulli, Angelo, Colombo, Paola Enrica, Fumagalli, Roberto, Torresin, Alberto, Langer, Thomas, Zadek, F, Berta, L, Zorzi, G, Ubiali, S, Bonaiuti, A, Tundo, G, Brunoni, B, Marrazzo, F, Giudici, R, Rossi, A, Rizzetto, F, Bernasconi, D, Vanzulli, A, Colombo, P, Fumagalli, R, Torresin, A, Langer, T, Zadek, Francesco, Berta, Luca, Zorzi, Giulia, Ubiali, Stefania, Bonaiuti, Amos, Tundo, Giulia, Brunoni, Beatrice, Marrazzo, Francesco, Giudici, Riccardo, Rossi, Anna, Rizzetto, Francesco, Bernasconi, Davide Paolo, Vanzulli, Angelo, Colombo, Paola Enrica, Fumagalli, Roberto, Torresin, Alberto, and Langer, Thomas

Abstract

Background: The use of the prone position (PP) has been widespread during the COVID-19 pandemic. While it has demonstrated benefits, including improved oxygenation and lung aeration, the factors influencing the response in terms of gas exchange to PP remain unclear. In particular, the association between baseline quantitative Computed Tomography (qCT) scan results and gas exchange response to PP in intubated, mechanically ventilated subjects with COVID-19 ARDS is unknown. The present study aimed to compare baseline qCT results between subjects responding to PP in terms of oxygenation or carbon dioxide (CO2) clearance and those who did not.Methods: This was a single-center, retrospective observational study, including critically ill, intubated, mechanically ventilated subjects with COVID-19 related acute respiratory distress syndrome admitted to the ICUs of Niguarda Hospital between March 2020 and November 2021. Blood-gas samples were collected before and after PP. Subjects in whom the PaO2/FiO2 increase was ≥ 20 mmHg after PP were defined as Oxygen responders (Oxy-R). CO2-responders (CO2R) were defined when the ventilatory ratio (VR) decreased during PP. Automated qCT analyses were performed to obtain tissue mass and density of the lungs.Results: One hundred twenty-five subjects were enrolled, of which 116 (93%) were Oxy-R and 51 (41%) CO2R. No difference in qCT characteristics and oxygen were observed between Oxy-R and Oxygen Non Responders (Tissue mass 1532 ±396 vs. 1654 ±304 g, p= .28; density -544±109 vs. -562±58 HU, p= .42). Similar findings were observed when dividing the population according to CO2 response (Tissue mass 1551±412 vs. 1534±377 g, p= .89; density -545±123 vs. -546±94 HU, p= .99).Conclusions: Most COVID-19 related ARDS subjects improve their oxygenation at the first pronation cycle. The study suggests that baseline qCT scan data are not associated with the response to PP in oxygenation or CO2 in mechanically ventilated COVID-19 related ARDS subje

Published
2024

43. Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study

Author

Lissoni, Alfredo, Rossi, Nicola, Guzzardella, Amedeo, Valsecchi, Carlo, Madotto, Fabiana, Bevilacqua, Francesca, Di Laudo, Marco, Querci, Lorenzo, Seccafico, Carmen, Grasselli, Giacomo, Tonetti, Tommaso, Protti, Alessandro, Langer, Thomas, Girardis, Massimo, Bellani, Giacomo, Laffey, John, Carrafiello, Gianpaolo, Carsana, Luca, Rizzuto, Chiara, Zanella, Alberto, Scaravilli, Vittorio, Pizzilli, Giacinto, Grieco, Domenico Luca, Di Meglio, Letizia, de Pascale, Gennaro, Lanza, Ezio, Monteduro, Francesco, Zompatori, Maurizio, Filippini, Claudia, Locatelli, Franco, Cecconi, Maurizio, Fumagalli, Roberto, Nava, Stefano, Vincent, Jean-Louis, Antonelli, Massimo, Slutsky, Arthur S, Pesenti, Antonio, and Ranieri, V Marco

Published
2020
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44. The role of intensive care unit diaries in the grieving process: A monocentric qualitative study.

Author

Bazzano, Giacomo, Buccoliero, Francesco, Villa, Marta, Pegoraro, Flavia, Iannuzzi, Luigi, Rona, Roberto, Fumagalli, Roberto, Giani, Marco, and Lucchini, Alberto

Subjects
FAMILIES & psychology, QUALITATIVE research, STATISTICAL significance, INTERVIEWING, EMOTIONS, PSYCHOLOGICAL adaptation, DESCRIPTIVE statistics, FAMILY attitudes, THEMATIC analysis, INTENSIVE care units, DIARY (Literary form), RESEARCH methodology, GRIEF, SOCIAL support, DATA analysis software
Abstract

Background: The growing importance of psychological recovery for patients and their families following intensive care unit (ICU) experiences in recent years cannot be overemphasized. The ICU diary is used to aid patients in reducing the prevalence of post-traumatic stress disorder, anxiety, and depression. The usefulness of maintaining a diary during the grieving process has not yet been thoroughly investigated. Aim: To investigate the role of ICU diaries in the grief process experienced by family members of a person who died in the intensive care unit. Study Design: Nine family members of seven deceased ICU patients with an ICU diary were contacted and interviewed by phone using a semi-structured interview. A qualitative data analysis was performed using thematic synthesis. Setting: Italian general intensive care unit. Findings: Interviewed family members felt that the diary helped them during the grieving process. The return of diaries was desired by family members for support and to remember one's loved one. The diary helped them process their losses in various ways, including signs of evidence of care, emotional involvement, consideration, and coping with grief. Four main themes emerged from the analysis: writing the diary, reading the diary, talking about the diary, and the diary during the grieving process. Conclusions: The overall perception of the ICU diary was positive. The diary mostly helped relatives to "give back something of what we lost". This study also affirms the positive link between ICU diaries and bereavement in Italian ICU. Further studies are required to confirm the usefulness of this tool in the grieving process. Relevance to Clinical Practice: The ICU diary can help patients' family members understand what happened to their loved one and play an important role in the grieving process. The diary served as a valuable source of information that aided in providing bereavement support to the family by helping them to gain a rational and emotional understanding of the patient's death. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Gas Humidification During Helmet Continuous Positive Airway Pressure

Author

Ambrosetti, Lorenzo, primary, Giani, Marco, additional, Rezoagli, Emanuele, additional, Fiorillo, Chiara, additional, Vitale, Daniela, additional, Giacchè, Damiano, additional, Ravasio, Giambattista, additional, Fumagalli, Roberto, additional, Foti, Giuseppe, additional, and Lucchini, Alberto, additional

Published
2024
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49. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE)

Author

Pham, Tài, Heunks, Leo, Bellani, Giacomo, Madotto, Fabiana, Aragao, Irene, Beduneau, Gaëtan, Goligher, Ewan C, Grasselli, Giacomo, Laake, Jon Henrik, Mancebo, Jordi, Peñuelas, Oscar, Piquilloud, Lise, Pesenti, Antonio, Wunsch, Hannah, van Haren, Frank, Brochard, Laurent, Laffey, John G, Abrough, Fekri, Acharya, Subhash P, Amin, Pravin, Arabi, Yaseen, Bauer, Philippe, Beitler, Jeremy, Berkius, Johan, Bugedo, Guillermo, Camporota, Luigi, Cerny, Vladimir, Cho, Young-Jae, Clarkson, Kevin, Estenssoro, Elisa, Goligher, Ewan, Gritsan, Alexey, Hashemian, Seyed Mohammadreza, Hermans, Greet, Heunks, Leo M, Jovanovic, Bojan, Kurahashi, Kiyoyasu, Matamis, Dimitrios, Moerer, Onnen, Molnar, Zsolt, Ozyilmaz, Ezgi, Panka, Bernardo, Papali, Alfred, Peñuelas, Óscar, Perbet, Sébastien, Qiu, Haibo, Razek, Assem Abdel, Rittayamai, Nuttapol, Roldan, Rollin, Serpa Neto, Ary, Szuldrzynski, Konstanty, Talmor, Daniel, Tomescu, Dana, Van Haren, Frank, Villagomez, Asisclo, Zeggwagh, Amine Ali, Abe, Toshikazu, Aboshady, Abdelrhman, Acampo-de Jong, Melanie, Acharya, Subhash, Adderley, Jane, Adiguzel, Nalan, Agrawal, Vijay Kumar, Aguilar, Gerardo, Aguirre, Gaston, Aguirre-Bermeo, Hernan, Ahlström, Björn, Akbas, Türkay, Akker, Mustafa, Al Sadeh, Ghamdan, Alamri, Sultan, Algaba, Angela, Ali, Muneeb, Aliberti, Anna, Allegue, Jose Manuel, Alvarez, Diana, Amador, Joaquin, Andersen, Finn H, Ansari, Sharique, Apichatbutr, Yutthana, Apostolopoulou, Olympia, Arellano, Daniel, Arica, Mestanza, Arikan, Huseyin, Arinaga, Koichi, Arnal, Jean-Michel, Asano, Kengo, Asín-Corrochano, Marta, Avalos Cabrera, Jesus Milagrito, Avila Fuentes, Silvia, Aydemir, Semih, Aygencel, Gulbin, Azevedo, Luciano, Bacakoglu, Feza, Badie, Julio, Baedorf Kassis, Elias, Bai, Gabriela, Balaraj, Govindan, Ballico, Bruno, Banner-Goodspeed, Valerie, Banwarie, Preveen, Barbieri, Rosella, Baronia, Arvind, Barrett, Jonathan, Barrot, Loïc, Barrueco-Francioni, Jesus Emilio, Barry, Jeffrey, Bawangade, Harshal, Beavis, Sarah, Beck, Eduardo, Beehre, Nina, Belenguer Muncharaz, Alberto, Belliato, Mirko, Bellissima, Agrippino, Beltramelli, Rodrigo, Ben Souissi, Asma, Benitez-Cano, Adela, Benlamin, Mohamed, Benslama, Abdellatif, Bento, Luis, Benvenuti, Daniela, Bernabe, Laura, Bersten, Andrew, Berta, Giacomo, Bertini, Pietro, Bertram-Ralph, Elliot, Besbes, Mohamed, Bettini, Lisandro Roberto, Beuret, Pascal, Bewley, Jeremy, Bezzi, Marco, Bhakhtiani, Lakshay, Bhandary, Rakesh, Bhowmick, Kaushik, Bihari, Shailesh, Bissett, Bernie, Blythe, David, Bocher, Simon, Boedjawan, Narain, Bojanowski, Christine M, Boni, Elisa, Boraso, Sabrina, Borelli, Massimo, Borello, Silvina, Borislavova, Margarita, Bosma, Karen J, Bottiroli, Maurizio, Boyd, Owen, Bozbay, Suha, Briva, Arturo, Bruel, Cédric, Bruni, Andrea, Buehner, Ulrike, Bulpa, Pierre, Burt, Karen, Buscot, Mathieu, Buttera, Stefania, Cabrera, Jorge, Caccese, Roberta, Caironi, Pietro, Canchos Gutierrez, Ivan, Canedo, Nancy, Cani, Alma, Cappellini, Iacopo, Carazo, Jesus, Cardonnet, Luis Pablo, Carpio, David, Carriedo, Demetrio, Carrillo, Ramón, Carvalho, João, Caser, Eliana, Castelli, Antonio, Castillo Quintero, Manuel, Castro, Heloisa, Catorze, Nuno, Cengiz, Melike, Cereijo, Enrique, Ceunen, Helga, Chaintoutis, Christos, Chang, Youjin, Chaparro, Gustavogcha, Chapman, Carmel, Chau, Simon, Chavez, Cecilia Eugenia, Chelazzi, Cosimo, Chelly, Jonathan, Chemouni, Frank, Chen, Kai, Chena, Ariel, Chiarandini, Paolo, Chilton, Phil, Chiumello, Davide, Chou-Lie, Yvette, Chudeau, Nicolas, Cinel, Ismail, Cinnella, Gilda, Clark, Michele, Clark, Thomas, Clementi, Stefano, Coaguila, Luis, Codecido, Alexis Jaspe, Collins, Amy, Colombo, Riccardo, Conde, Juan, Consales, Guglielmo, Cook, Tim, Coppadoro, Andrea, Cornejo, Rodrigo, Cortegiani, Andrea, Coxo, Cristina, Cracchiolo, Andrea Neville, Crespo Ramirez, Mónica, Crova, Philippe, Cruz, José, Cubattoli, Lucia, Çukurova, Zafer, Curto, Francesco, Czempik, Piotr, D'Andrea, Rocco, da Silva Ramos, Fernando, Dangers, Laurence, Danguy des Déserts, Marc, Danin, Pierre-Eric, Dantas, Fabianne, Daubin, Cédric, Dawei, Wu, de Haro, Candelaria, de Jesus Montelongo, Felipe, De Mendoza, Diego, de Pablo, Raúl, De Pascale, Gennaro, De Rosa, Silvia, Decavèle, Maxens, Declercq, Pierre-Louis, Deicas, Alberto, del Carmen Campos Moreno, María, Dellamonica, Jean, Delmas, Benjamin, Demirkiran, Oktay, Demirkiran, Hilmi, Dendane, Tarek, di Mussi, Rossella, Diakaki, Chrysi, Diaz, Anatilde, Diaz, Willy, Dikmen, Yalim, Dimoula, Aikaterini, Doble, Patricia, Doha, Nagwa, Domingos, Guilherme, Dres, Martin, Dries, David, Duggal, Abhijit, Duke, Graeme, Dunts, Pavel, Dybwik, Knut, Dykyy, Maksym, Eckert, Philippe, Efe, Serdar, Elatrous, Souheil, Elay, Gülseren, Elmaryul, Abubaker S, Elsaadany, Mohamed, Elsayed, Hany, Elsayed, Samar, Emery, Malo, Ena, Sébastien, Eng, Kevin, Englert, Joshua A, Erdogan, Elif, Ergin Ozcan, Perihan, Eroglu, Ege, Escobar, Miguel, Esen, Figen, Esen Tekeli, Arzu, Esquivel, Alejandro, Esquivel Gallegos, Helbert, Ezzouine, Hanane, Facchini, Alberto, Faheem, Mohammad, Fanelli, Vito, Farina, Maria Fernanda, Fartoukh, Muriel, Fehrle, Lutz, Feng, Feng, Feng, Yufeng, Fernandez, Irene, Fernandez, Borja, Fernandez-Rodriguez, Maria Lorena, Ferrando, Carlos, Ferreira da Silva, Maria João, Ferreruela, Mireia, Ferrier, Janet, Flamm Zamorano, Matias Jesús, Flood, Laura, Floris, Leda, Fluckiger, Martin, Forteza, Catalina, Fortunato, Antonella, Frans, Eric, Frattari, Antonella, Fredes, Sebastian, Frenzel, Tim, Fumagalli, Roberto, Furche, Mariano Andres, Fusari, Maurizio, Fysh, Edward, Galeas-Lopez, Juan Luis, Galerneau, Louis-Marie, Garcia, Analía, Garcia, María Fernanda, Garcia, Elisabet, Garcia Olivares, Pablo, Garlicki, Jaroslaw, Garnero, Aude, Garofalo, Eugenio, Gautam, Prabha, Gazenkampf, Andrey, Gelinotte, Stéphanie, Gelormini, Domenico, Ghrenassia, Etienne, Giacomucci, Angelo, Giannoni, Robert, Gigante, Andrea, Glober, Nancy, Gnesin, Paolo, Gollo, Yari, Gomaa, Dina, Gomero Paredes, Rosita, Gomes, Rui, Gomez, Raúl Alejandro, Gomez, Oscar, Gomez, Aroa, Gondim, Louise, Gonzalez, Manuel, Gonzalez, Isabel, Gonzalez-Castro, Alejandro, Gordillo Romero, Orlando, Gordo, Federico, Gouin, Philippe, Graf Santos, Jerónimo, Grainne, Rooney, Grando, Matilde, Granov Grabovica, Sanja, Grasso, Salvatore, Grasso, Rinaldo, Grimmer, Lisa, Grissom, Colin, Gu, Qing, Guan, Xiang-Dong, Guarracino, Fabio, Guasch, Neus, Guatteri, Luca, Gueret, Renaud, Guérin, Claude, Guerot, Emmanuel, Guitard, Pierre-Gildas, Gül, Fethi, Gumus, Ayca, Gurjar, Mohan, Gutierrez, Patricia, Hachimi, Abdelhamid, Hadzibegovic, Adi, Hagan, Samantha, Hammel, Clare, Han Song, Joo, Hanlon, Gabrielle, Heines, Serge, Henriksson, Johanna, Herbrecht, Jean-Etienne, Heredia Orbegoso, Gabriel Omar, Hermon, Andrew, Hernandez, Rosana, Hernandez, Carmen, Herrera, Luis, Herrera-Gutierrez, Manuel, Hidalgo, Juan, Hill, Dianne, Holmquist, Dagmar, Homez, Marcela, Hongtao, Xia, Hormis, Anil, Horner, Daniel, Hornos, M Carmen, Hou, Meihong, House, Stacy, Housni, Brahim, Hugill, Keith, Humphreys, Sally, Humbert, Louis, Hunter, Stephanie, Hwa Young, Lee, Iezzi, Nicolas, Ilutovich, Santiago, Inal, Volkan, Innes, Richard, Ioannides, Panagiotis, Iotti, Giorgio Antonio, Ippolito, Mariachiara, Irie, Hiromasa, Iriyama, Hiroki, Itagaki, Taiga, Izura, Javier, Izza, Santiago, Jabeen, Rakhshanda, Jamaati, Hamidreza, Jamadarkhana, Sunil, Jamoussi, Amira, Jankowski, Milosz, Jaramillo, Luis Alberto, Jeon, Kyeongman, Jeong Lee, Seok, Jeswani, Deepak, Jha, Simant, Jiang, Liangyan, Jing, Chen, Jochmans, Sébastien, Johnstad, Bror Anders, Jongmin, Lee, Joret, Aurélie, Junhasavasdikul, Detajin, Jurado, Maria Teresa, Kam, Elisa, Kamohara, Hidenobu, Kane, Caroline, Kara, Iskender, Karakurt, Sait, Karnjanarachata, Cherdkiat, Kataoka, Jun, Katayama, Shinshu, Kaushik, Shuchi, Kelebek Girgin, Nermin, Kerr, Kathryn, Kerslake, Ian, Khairnar, Prakash, Khalid, Abidi, Khan, Akram, Khanna, Ashish K, Khorasanee, Reza, Kienhorst, Dieneke, Kirakli, Cenk, Knafelj, Rihard, Kol, Mark Kol, Kongpolprom, Napplika, Kopitko, Csaba, Korkmaz Ekren, Pervin, Kubisz-Pudelko, Agnieszka, Kulcsar, Zoltan, Kumasawa, Junji, Kuriyama, Akira, Kutchak, Fernanda, Labarca, Eduardo, Labat, Françoise, Laborda, César, Laca Barrera, Manuel Alberto, Lagache, Laurie, Landaverde Lopez, Antonio, Lanspa, Michael, Lascari, Valeria, Le Meur, Matthieu, Lee, Su Hwan, Lee, Young Ju, Lee, Jinwoo, Lee, Won-Yeon, Lee, Jarone, Legernaes, Terje, Leiner, Tamaas, Lemiale, Virginie, Leonor, Tiago, Lepper, Philipp M, Li, Dahuan, Li, Hongbin, Li, Oleg, Lima, Ana Raquel, Lind, Dan, Litton, Edward, Liu, Ning, Liu, Ling, Liu, Jialin, Llitjos, Jean-François, Llorente, Beatriz, Lopez, Rodolfo, Lopez, Claudia Elizabeth, Lopez Nava, Claudia, Lovazzano, Pablo, Lu, Min, Lucchese, Francesca, Lugano, Manuela, Lugo Goytia, Gustavo, Luo, Hua, Lynch, Ceri, Macheda, Sebastiano, Madrigal Robles, Victor Hugo, Maggiore, Salvatore Maurizio, Magret Iglesias, Mònica, Malaga, Peter, Mallapura Maheswarappa, Harish, Malpartida, Guillermo, Malyarchikov, Andrey, Mansson, Helena, Manzano, Anaid, Marey, Ismael, Marin, Nathalie, Marin, Maria del Carmen, Markman, Eliana, Martin, Felix, Martin, Alex, Martin Dal Gesso, Cristina, Martinez, Felipe, Martínez-Fidalgo, Conchita, Martin-Loeches, Ignacio, Mas, Arantxa, Masaaki, Sakuraya, Maseda, Emilio, Massa, Eleni, Mattsson, Anna, Maugeri, Jessica, McCredie, Victoria, McCullough, James, McGuinness, Shay, McKown, Andrew, Medve, László, Mei, Chengqing, Mellado Artigas, Ricard, Mendes, Vitor, Mervat, Mohamed Khalaf Ebraheim, Michaux, Isabelle, Mikhaeil, Michael, Milagros, Olga, Milet, Igor, Millan, Maria Teresa, Minwei, Zhang, Mirabella, Lucia, Mishra, Sanghamitra, Mistraletti, Giovanni, Mochizuki, Katsunori, Moghal, Arif, Mojoli, Francesco, Molin, Alexandre, Montiel, Raquel, Montini, Luca, Monza, Gianmario, Mora Aznar, Maria, Morakul, Sunthiti, Morales, Maria, Moreno Torres, Daniel, Morocho Tutillo, Diego Rolando, Motherway, Catherine, Mouhssine, Doumiri, 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Subjects
Pulmonary and Respiratory Medicine, Internal Medicine Sciences, Klinik Tıp, RESPIRATORY SYSTEM, Dahili Tıp Bilimleri, Göğüs Hastalıkları ve Allerji, CLINICAL MEDICINE, Sağlık Bilimleri, Clinical Medicine (MED), Tıp, SOLUNUM SİSTEMİ, Mechanical ventilation, N/A, Health Sciences, Settore MED/41 - ANESTESIOLOGIA, Akciğer ve Solunum Tıbbı, Medicine, Klinik Tıp (MED), Chest Diseases and Allergy
Abstract

Background: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0–4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 day), 457 (10·1%) had intermediate weaning (2–6 days), 433 (9·6%) required prolonged weaning (≥7 days), and 706 (15·6%) had weaning failure. Higher sedation scores were independently associated with delayed initiation of weaning. Delayed initiation of weaning and higher sedation scores were independently associated with weaning failure. 1742 (31·8%) of 5479 patients died in the intensive care unit and 2095 (38·3%) of 5465 patients died in hospital. Interpretation: In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days. A better understanding of factors that delay the weaning process, such as delays in weaning initiation or excessive sedation levels, might improve weaning success rates. Funding: European Society of Intensive Care Medicine, European Respiratory Society.

Published
2023

50. Impact of the COVID-19 outbreak on severe trauma trends and healthcare system reassessment in Lombardia, Italy: an analysis from the regional trauma registry

Author

Giudici, Riccardo, Lancioni, Armando, Gay, Hedwige, Bassi, Gabriele, Chiara, Osvaldo, Mare, Claudio, Latronico, Nicola, Pesenti, Antonio, Faccincani, Roberto, Cabrini, Luca, Fumagalli, Roberto, Chieregato, Arturo, Briani, Laura, Sammartano, Fabrizio, Sechi, Giuseppe, Zoli, Alberto, Pagliosa, Andrea, Foti, Giuseppe, Borotto, Erika, Palo, Alessandra, Valoti, Oliviero, Botteri, Marco, Carlucci, Michele, Reitano, Elisa, and Bini, Roberto

Published
2021
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