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1. Pivotal trial of the Neuroform Atlas stent for treatment of posterior circulation aneurysms: one-year outcomes

Author

Jankowitz, Brian T, Jadhav, Ashutosh P, Gross, Bradley, Jovin, Tudor G, Alhajeri, Abdulnasser A, Fraser, Justin F, Hanel, Ricardo A, Sauvageau, Eric, Aghaebrahim, Amin, Frei, Donald, Bellon, Richard, Loy, David, Puri, Ajit S, Malek, Adel M, Thomas, Ajith, Toth, Gabor, Lopes, Demetrius Klee, Crowley, R Webster, Arthur, Adam S, Reavey-Cantwell, John, Lin, Eugene, Siddiqui, Adnan H, Alexander, Michael J, Khaldi, Ahmad, Colby, Geoffrey P, Caplan, Justin M, Satti, Sudhakar R, Turk, Aquilla S, Spiotta, Alejandro M, Klucznik, Richard, Hallam, Danial K, Kung, David, Froehler, Michael T, Callison, R Charles, Kan, Peter, Hetts, Steven W, and Zaidat, Osama O

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Bioengineering, Clinical Trials and Supportive Activities, Assistive Technology, Stroke, Neurosciences, Clinical Research, Aged, Cerebral Angiography, Embolization, Therapeutic, Female, Humans, Intracranial Aneurysm, Middle Aged, Prospective Studies, Retrospective Studies, Stents, Treatment Outcome, aneurysm, coil, stent, Clinical sciences
Abstract

BackgroundStent-assisted coiling of wide-necked intracranial aneurysms (IAs) using the Neuroform Atlas Stent System (Atlas) has shown promising results.ObjectiveTo present the primary efficacy and safety results of the ATLAS Investigational Device Exemption (IDE) trial in a cohort of patients with posterior circulation IAs.MethodsThe ATLAS trial is a prospective, multicenter, single-arm, open-label study of unruptured, wide-necked, IAs treated with the Atlas stent and adjunctive coiling. This study reports the results of patients with posterior circulation IAs. The primary efficacy endpoint was complete aneurysm occlusion (Raymond-Roy (RR) class I) on 12-month angiography, in the absence of re-treatment or parent artery stenosis >50%. The primary safety endpoint was any major ipsilateral stroke or neurological death within 12 months. Adjudication of the primary endpoints was performed by an imaging core laboratory and a Clinical Events Committee.ResultsThe ATLAS trial enrolled and treated 116 patients at 25 medical centers with unruptured, wide-necked, posterior circulation IAs (mean age 60.2±10.5 years, 81.0% (94/116) female). Stents were placed in all patients with 100% technical success rate. A total of 95/116 (81.9%) patients had complete angiographic follow-up at 12 months, of whom 81 (85.3%) had complete aneurysm occlusion (RR class I). The primary effectiveness outcome was achieved in 76.7% (95% CI 67.0% to 86.5%) of patients. Overall, major ipsilateral stroke and secondary persistent neurological deficit occurred in 4.3% (5/116) and 1.7% (2/116) of patients, respectively.ConclusionsIn the ATLAS IDE posterior circulation cohort, the Neuroform Atlas Stent System with adjunctive coiling demonstrated high rates of technical and safety performance. Trial registration number https://clinicaltrials.gov/ct2/show/NCT02340585.

Published
2022

6. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial

Author

Alonso, Angelika, Arquizan, Caroline, Barreau, Xavier, Beaujeux, Rémy, Behme, Daniel, Boeckh-Behrens, Tobias, Boehme, Christian, Boix, Martí, Boulouis, Grégoire, Bricout, Nicolas, Broc, Nicolas, Cereda, Carlo W., Chabert, Emmanuel, Cho, Tae-Hee, Cianfoni, Alessandro, Costalat, Vincent, Denier, Christian, Di Maria, Frederico, du Mesnil de Rochemont, Richard, Fearon, Patricia, Ferrier, Anna, Fischer, Sebastian, Gauberti, Maxime, Gaudron, Marie, Gimenez, Laetitia, Globas, Christoph, Görtler, Michael, Goyal, Mayank, Hilker-Roggendorf, Ruediger, Hill, Michael D., Hua, Vi Tuan, Humbertjean, Lisa, Jansen, Olav, Jung, Simon, Kägi, Georg, Kelly, Michael E., Kleffner, Ilka, Knoflach, Michael, Nedeltchev, Krassen, Krause, Lars Udo, Lappalainen, Kimmo, Lefebvre, Margaux, Leyon, Joe, Liao, Liang, Liegey, Jean-Sebastien, Loehr, Christian, Michel, Patrik, Nannoni, Stefania, Nicholson, Patrick, Nico, Lorena, Obadia, Michael, Ognard, Julien, Ogungbemi, Ayokunle, Olivot, Jean-Marc, Escalard, Simon, Pasi, Marco, Peeling, Lissa, Perez, Jane, Petersen, Martina, Piechowiak, Eike, Raposo, Roberto, Räty, Silja, Reitz, Sarah C., Remollo, Sebastià, Remonda, Luca, Rennie, Ian, Requena, Manuel, Riabikin, Alexander, Riva, Roberto, Rouchaud, Aymeric, Rosi, Andrea, Rubiera, Marta, Spelle, Laurent, Schnieder, Marlena, Schaafsma, Joanna D., Schubert, Tilman, Schulz, Jörg B., Siddiqui, Mohammed, Soize, Sébastien, Sonnberger, Michael, Touze, Emmanuel, Triquenot, Aude, Turc, Guillaume, Vieira, Lucy, Ben Hassen, Wagih, Wagner, Judith N., Wasser, Katrin, Weber, Johannes, Wenz, Holger, Weisenburger-Lile, David, Wodarg, Fritz, Wolff, Valérie, Wunderlich, Silke, Fischer, Urs, Kaesmacher, Johannes, Strbian, Daniel, Eker, Omer, Cognard, Christoph, Plattner, Patricia S, Bütikofer, Lukas, Mordasini, Pasquale, Deppeler, Sandro, Pereira, Vitor M, Albucher, Jean François, Darcourt, Jean, Bourcier, Romain, Benoit, Guillon, Papagiannaki, Chrysanthi, Ozkul-Wermester, Ozlem, Sibolt, Gerli, Tiainen, Marjaana, Gory, Benjamin, Richard, Sébastien, Liman, Jan, Ernst, Marielle Sophie, Boulanger, Marion, Barbier, Charlotte, Mechtouff, Laura, Zhang, Liqun, Marnat, Gaultier, Sibon, Igor, Nikoubashman, Omid, Reich, Arno, Consoli, Arturo, Lapergue, Bertrand, Ribo, Marc, Tomasello, Alejandro, Saleme, Suzana, Macian, Francisco, Moulin, Solène, Pagano, Paolo, Saliou, Guillaume, Carrera, Emmanuel, Janot, Kevin, Hernández-Pérez, María, Pop, Raoul, Schiava, Lucie Della, Luft, Andreas R, Piotin, Michel, Gentric, Jean Christophe, Pikula, Aleksandra, Pfeilschifter, Waltraud, Arnold, Marcel, Siddiqui, Adnan H, Froehler, Michael T, Furlan, Anthony J, Chapot, René, Wiesmann, Martin, Machi, Paolo, Diener, Hans-Christoph, Kulcsar, Zsolt, Bonati, Leo H, Bassetti, Claudio L, Mazighi, Mikael, Liebeskind, David S, Saver, Jeffrey L, and Gralla, Jan

Published
2022
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7. Decompressive craniectomy in symptomatic intracerebral hemorrhage after ischemic stroke: a multicenter retrospective cohort study.

Author

Pressman, Elliot, Gersey, Zachary C., Jonzzon, Soren B., Weinberg, Joshua H., Fogg,BS, David N., Flaherty, Emily G., Gross, Bradley A., Chitale, Rohan V., Fusco, Matthew R., Froehler, Michael T., Vignolles-Jeong, Joshua, Nimjee, Shahid M., Hanel, Ricardo A., Cortez, Gustavo M., Ravi, Saisree, Desai, Sohum K., Hassan, Ameer E., Monteiro, Andre, Siddiqui, Adnan H., and Matsoukas, Stavros

Published
2025
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8. Venous sinus stenting versus ventriculoperitoneal shunting: comparing clinical outcomes for idiopathic intracranial hypertension.

Author

Hilvert, Austin Michael, Gauhar, Fatima, Longo, Michael, Grimaudo, Heather, Dugan, John, Mummareddy, Nishit, Chitale, Rohan, Froehler, Michael T., and Fusco, Matthew R.

Subjects
HYPERTENSION, INTRACRANIAL hypertension, SURGICAL stents, TREATMENT effectiveness, RETROSPECTIVE studies, DESCRIPTIVE statistics, ODDS ratio, MEDICAL records, ACQUISITION of data, CASE-control method, COMPARATIVE studies, CEREBROSPINAL fluid shunts
Abstract

Background Venous sinus stenting (VSS) has been shown to reduce intracranial venous pressures and improve symptoms in patients with idiopathic intracranial hypertension (IIH). However, long-term follow-up data are limited, raising concerns about sustained symptom improvement. We aimed to assess long-term outcomes of VSS compared with ventriculoperitoneal shunting (VPS). Methods A retrospective case-control study assessed 87 patients with IIH who met inclusion criteria and underwent either VSS (n=27) or VPS (n=60) between 2017 and 2022. Descriptive statistics for baseline characteristics and outcomes were calculated, followed by multivariate logistic regression to identify factors associated with headache recurrence. Results Baseline characteristics were similar between VSS and VPS groups, including age (p=0.58), sex (p=0.74), body mass index (p=0.47), and preoperative lumbar puncture opening pressure (p=0.62). Preoperative symptoms of headaches (p=0.42), papilledema (p=0.35), and pulsatile tinnitus (p=0.56) were also similar. Initial headache improvement was comparable (96% vs 91%, p=0.42). However, headache recurrence was less common in the VSS group (31% vs 60%, p=0.015) at the last follow-up, averaging over 1 year. Multivariate analysis showed VSS was independently associated with reduced odds of headache recurrence (OR 0.24, p=0.015). Longer follow-up was associated with increased odds of headache recurrence in both groups (OR 1.01, p=0.032). Conclusion VSS was independently associated with reduced odds of headache recurrence compared with VPS in multivariate analysis. Longer follow-up was significantly associated with headache recurrence in both groups. This suggests that VSS may lead to better outcomes for continued headache relief, but headache recurrence may increase with longer follow-up regardless of treatment modality. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Primary results from the CLEAR study of a novel stent retriever with drop zone technology.

Author

Yoo, Albert J., Geyik, Serdar, Froehler, Michael T., Maurer, Christoph Johannes, Kass-Hout, Tareq, Zaidat, Osama O., Nogueira, Raul G., Hanel, Ricardo A., Pierot, Laurent, Spelle, Laurent, Lopes, Demetrius, Hassan, Ameer, Širvinskas, Audrius, Lin, Eugene, Ribo, Marc, Blasco, Jordi, Taqi, Muhammad Asif, Badruddin, Aamir, Siddiqui, Adnan H., and Miller, Timothy R.

Subjects
INTRACRANIAL hemorrhage, NIH Stroke Scale, PATIENT safety, DATA analysis, RESEARCH funding, BLOOD vessels, CLINICAL trials, REVASCULARIZATION (Surgery), TREATMENT effectiveness, SURGICAL stents, DESCRIPTIVE statistics, HOSPITAL mortality, LONGITUDINAL method, RESEARCH, STATISTICS, VASCULAR diseases, EVALUATION, DISEASE risk factors
Abstract

Background Challenges to revascularization of large vessel occlusions (LVOs) persist. Current stent retrievers have limited effectiveness for removing organized thrombi. The NeVa device is a novel stent retriever designed to capture organized thrombi within the scaffold during retrieval. Objective To evaluate the safety and effectiveness of revascularization of acute LVOs with the NeVa device. Methods Prospective, international, multicenter, singlearm, Investigational Device Exemption study to evaluate the performance of the NeVa device in recanalizing LVOs including internal carotid artery, M1/M2 middle cerebral artery, and vertebrobasilar arteries, within 8 hours of onset. Primary endpoint was rate of expanded Treatment in Cerebral Ischemia (eTICI) score 2b-3 within 3 NeVa passes, tested for non-inferiority against a performance goal of 72% with a -10% margin. Additional endpoints included first pass success and 90-day modified Rankin Scale (mRS) score 0-2. Primary composite safety endpoint was 90-day mortality and/or 24-hour symptomatic intracranial hemorrhage (sICH). Results From April 2021 to April 2022, 139 subjects were enrolled at 25 centers. Median National Institutes of Health Stroke Scale (NIHSS) score was 16 (IQR 12-20). In the primary analysis population (n=107), eTICI 2b-3 within 3 NeVa passes occurred in 90.7% (97/107; non-inferiority P<0.0001; post hoc superiority P<0.0001). First pass eTICI 2b-3 was observed in 73.8% (79/107), with first pass eTICI 2b67-3 in 69.2% (74/107) and eTICI 2c-3 in 48.6% (52/107). Median number of passes was 1 (IQR 1-2). Final eTICI 2b-3 rate was 99.1% (106/107); final eTICI 2b67-3 rate was 91.6% (98/107); final eTICI 2c-3 rate was 72.9% (78/107). Good outcome (90-day mRS score 0-2) was seen in 65.1% (69/106). Mortality was 9.4% (13/138) with sICH in 5.0% (7/139). Conclusions The NeVa device is highly effective and safe for revascularization of LVO strokes and demonstrates superior first pass success compared with a predicate performance goal. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Interhospital Transfer Before Thrombectomy Is Associated With Delayed Treatment and Worse Outcome in the STRATIS Registry (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke)

Author

Froehler, Michael T, Saver, Jeffrey L, Zaidat, Osama O, Jahan, Reza, Aziz-Sultan, Mohammad Ali, Klucznik, Richard P, Haussen, Diogo C, Hellinger, Frank R, Yavagal, Dileep R, Yao, Tom L, Liebeskind, David S, Jadhav, Ashutosh P, Gupta, Rishi, Hassan, Ameer E, Martin, Coleman O, Bozorgchami, Hormozd, Kaushal, Ritesh, Nogueira, Raul G, Gandhi, Ravi H, Peterson, Eric C, Dashti, Shervin R, Given, Curtis A, Mehta, Brijesh P, Deshmukh, Vivek, Starkman, Sidney, Linfante, Italo, McPherson, Scott H, Kvamme, Peter, Grobelny, Thomas J, Hussain, Muhammad S, Thacker, Ike, Vora, Nirav, Chen, Peng Roc, Monteith, Stephen J, Ecker, Robert D, Schirmer, Clemens M, Sauvageau, Eric, Abou-Chebl, Alex, Derdeyn, Colin P, Maidan, Lucian, Badruddin, Aamir, Siddiqui, Adnan H, Dumont, Travis M, Alhajeri, Abdulnasser, Taqi, M Asif, Asi, Khaled, Carpenter, Jeffrey, Boulos, Alan, Jindal, Gaurav, Puri, Ajit S, Chitale, Rohan, Deshaies, Eric M, Robinson, David H, Kallmes, David F, Baxter, Blaise W, Jumaa, Mouhammad A, Sunenshine, Peter, Majjhoo, Aniel, English, Joey D, Suzuki, Shuichi, Fessler, Richard D, Almandoz, Josser E Delgado, Martin, Jerry C, and Mueller-Kronast, Nils H

Subjects
Stroke, Clinical Research, Brain Disorders, Endovascular Procedures, Hospitals, Humans, Ischemia, Patient Transfer, Prospective Studies, Registries, Survival Analysis, Thrombectomy, Time Factors, Treatment Outcome, emergency medical services, endovascular treatment, ischemic stroke, stent retriever, systems of care, STRATIS Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundEndovascular treatment with mechanical thrombectomy (MT) is beneficial for patients with acute stroke suffering a large-vessel occlusion, although treatment efficacy is highly time-dependent. We hypothesized that interhospital transfer to endovascular-capable centers would result in treatment delays and worse clinical outcomes compared with direct presentation.MethodsSTRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter, observational, single-arm study of real-world MT for acute stroke because of anterior-circulation large-vessel occlusion performed at 55 sites over 2 years, including 1000 patients with severe stroke and treated within 8 hours. Patients underwent MT with or without intravenous tissue plasminogen activator and were admitted to endovascular-capable centers via either interhospital transfer or direct presentation. The primary clinical outcome was functional independence (modified Rankin Score 0-2) at 90 days. We assessed (1) real-world time metrics of stroke care delivery, (2) outcome differences between direct and transfer patients undergoing MT, and (3) the potential impact of local hospital bypass.ResultsA total of 984 patients were analyzed. Median onset-to-revascularization time was 202.0 minutes for direct versus 311.5 minutes for transfer patients (P

Published
2017

16. Investigation of stent retriever removal forces in an experimental model of acute ischemic stroke.

Author

Poulos, Demitria A., Froehler, Michael T., and Good, Bryan C.

Subjects
ISCHEMIC stroke, THROMBOSIS, MECHANICAL models, TORTUOSITY, THROMBECTOMY
Abstract

Introduction: Mechanical thrombectomy becomes more complex when the occlusion occurs in a tortuous cerebral anatomy, increasing the puncture to reperfusion time and the number of attempts for clot removal. Therefore, an understanding of stent retriever performance in these locations is necessary to increase the efficiency and safety of the procedure. An in vitro investigation into the effects of occlusion site tortuosity, blood clot hematocrit, and device geometry was conducted to identify their individual influence on stent retriever removal forces. Methods: Embolus analogs were used to create occlusions in a mock circulatory flow loop, and in vitro mechanical thrombectomies were performed in arterial models of increasing tortuosity. The stent retriever removal forces of Solitaire Platinum and EmboTrap II devices were recorded through each geometry with and without embolus analogs present. Similar experiments were also conducted with Solitaire stent retrievers of varying lengths and diameters and 0, 25, and 50% hematocrit embolus analogs. Results: The removal force increased as model tortuosity increased for both the Solitaire Platinum and EmboTrap II stent retriever devices. The average removal forces in the simplest geometry with the Solitaire Platinum and EmboTrap II were 0.24 ± 0.01 N and 0.37 ± 0.02 N, respectively, and increased to 1.2 ± 0.08 N and 1.6 ± 0.17 N, respectively, in the most complex geometry. Slight increases in removal force were found with 0% hematocrit embolus analogs, however, no statistical significance between removal force and EA hematocrit was observed. A comparison between stent retriever removal forces between devices of different diameters also proved to be significant (p < 0.01), while forces between devices of varying lengths were not (p > 0.05). Conclusion: Benchtop mechanical thrombectomies performed with commercial stent retrievers of varying geometry showed that device removal forces increase with increasing model tortuosity, clot hematocrit does not play a significant role in device removal force, and that a stent retriever's diameter has a greater impact on removal forces compared to its length. These results provide an improved understanding of the overall forces involved in mechanical thrombectomy and can be used to develop safer and more effective stent retrievers for the most difficult cases. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Mechanical Thrombectomy in Ischemic Stroke Patients with Severe Pre-Stroke Disability

Author

Salwi, Sanjana, Cutting, Shawna, Salgado, Alan D., Espaillat, Kiersten, Fusco, Matthew R., Froehler, Michael T., Chitale, Rohan V., Kirshner, Howard, Schrag, Matthew, Jasne, Adam, Burton, Tina, Grory, Brian Mac, Saad, Ali, Jayaraman, Mahesh V., Madsen, Tracy E., Dakay, Katarina, McTaggart, Ryan, Yaghi, Shadi, Khatri, Pooja, Mistry, Akshitkumar M., and Mistry, Eva A.

Published
2020
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18. Predictors of acute post-thrombectomy intracranial hemorrhage expansion in anterior circulation infarcts

Author

Bhamidipati, Akshay, primary, Mummareddy, Nishit, additional, Ahn, Seoiyoung, additional, Bendfeldt, Gabriel, additional, Lyons, Alexander T, additional, Gangavarapu, Surya, additional, Chen, Jeffrey, additional, Jo, Jacob, additional, Kamal, Naveed, additional, Roth, Steven G, additional, Froehler, Michael T, additional, Chitale, Rohan V, additional, and Fusco, Matthew R, additional

Published
2024
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21. Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection

Author

Albers, Gregory W., primary, Jumaa, Mouhammad, additional, Purdon, Barbara, additional, Zaidi, Syed F., additional, Streib, Christopher, additional, Shuaib, Ashfaq, additional, Sangha, Navdeep, additional, Kim, Minjee, additional, Froehler, Michael T., additional, Schwartz, Neil E., additional, Clark, Wayne M., additional, Kircher, Charles E., additional, Yang, Ming, additional, Massaro, Lori, additional, Lu, Xiao-Yu, additional, Rippon, Gregory A., additional, Broderick, Joseph P., additional, Butcher, Ken, additional, Lansberg, Maarten G., additional, Liebeskind, David S., additional, Nouh, Amre, additional, Schwamm, Lee H., additional, and Campbell, Bruce C.V., additional

Published
2024
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26. Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions

Author

Leira, Enrique C., Russman, Andrew N., Biller, José, Brown, Devin L., Bushnell, Cheryl D., Caso, Valeria, Chamorro, Angel, Creutzfeldt, Claire J., Cruz-Flores, Salvador, Elkind, Mitchell S.V., Fayad, Pierre, Froehler, Michael T., Goldstein, Larry B., Gonzales, Nicole R., Kaskie, Brian, Khatri, Pooja, Livesay, Sarah, Liebeskind, David S., Majersik, Jennifer J., Moheet, Asma M., Romano, Jose G., Sanossian, Nerses, Sansing, Lauren H., Silver, Brian, Simpkins, Alexis N., Smith, Wade, Tirschwell, David L., Wang, David Z., Yavagal, Dileep R., and Worrall, Bradford B.

Published
2020
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27. Mechanical Thrombectomy in Patients With Ischemic Stroke With Prestroke Disability

Author

Salwi, Sanjana, Cutting, Shawna, Salgado, Alan D., Espaillat, Kiersten, Fusco, Matthew R., Froehler, Michael T., Chitale, Rohan V., Kirshner, Howard, Schrag, Matthew, Jasne, Adam, Burton, Tina, MacGrory, Brian, Saad, Ali, Jayaraman, Mahesh V., Madsen, Tracy E., Dakay, Katarina, McTaggart, Ryan, Yaghi, Shadi, Khatri, Pooja, Mistry, Akshitkumar M., and Mistry, Eva A.

Published
2020
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28. Site Experience and Outcomes in the Trevo Acute Ischemic Stroke (TRACK) Multicenter Registry: Higher Volumes Translate in Better Outcomes

Author

Nogueira, Raul G., Haussen, Diogo C., Castonguay, Alicia, Rebello, Leticia C., Abraham, Michael, Puri, Ajit, Alshekhlee, Amer, Majjhoo, Aniel, Farid, Hamed, Finch, Ira, English, Joey, Mokin, Maxim, Froehler, Michael T., Kabbani, Mo, Taqi, Muhammad A., Vora, Nirav, Khoury, Ramy El, Edgell, Randall C., Novakovic, Roberta, Nguyen, Thanh, Janardhan, Vallabh, Veznedaroglu, Enrol, Prabhakaran, Shyam, Budzik, Ron, Frankel, Michael R., Nordhaus, Brittany L., and Zaidat, Osama O.

Published
2019
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29. O11/103 Primary results from the CLEAR study: safety and efficacy of the NeVa Stent Retriever for large vessel thrombectomy

Author

Geyik, Serdar, primary, Yoo, Albert, additional, Froehler, Michael T, additional, Maurer, Christoph J, additional, Kass-Hout, Tareq, additional, Pierot, Laurent, additional, Ribo, Marc, additional, Sirvinskas, Audrius, additional, Lin, Eugene, additional, Badruddin, Aamir, additional, Blasco, Jordi, additional, Taqi, Muhammad, additional, Siddiqui, Adnan, additional, Miller, Timothy, additional, Shazam Hussain, M, additional, Woodward, Keith, additional, Spelle, Laurent, additional, Groden, Christoph, additional, Hanel, Ricardo, additional, Chaudry, Imran, additional, Consoli, Arturo, additional, Ramsey, Christian, additional, Maud, Alberto, additional, Zaidat, Osama, additional, Nogueira, Raul, additional, Haussen, Diogo C, additional, Fiehler, Jens, additional, and Gupta, Rishi, additional

Published
2023
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31. Intraarterial Thrombolysis as Rescue Therapy for Large Vessel Occlusions: Analysis From the North American Solitaire Stent-Retriever Acute Stroke Registry

Author

Zaidi, Syed F., Castonguay, Alicia C., Jumaa, Mouhammad A., Malisch, Tim W., Linfante, Italo, Marden, Franklin A., Abraham, Michael G., Chebl, Alex Bou, Novakovic, Roberta, Taqi, M. Asif, Nogueira, Raul G., Martin, Coleman O., Holloway, William E., Mueller-Kronast, Nils, English, Joey D., Dabus, Guilherme, Bozorgchami, Hormozd, Xavier, Andrew, Rai, Ansaar T., Froehler, Michael T., Badruddin, Aamir, Nguyen, Thanh N., Yoo, Albert J., Shaltoni, Hashem, Janardhan, Vallabh, Chen, Peng R., Britz, Gavin W., Kaushal, Ritesh, Nanda, Ashish, Gupta, Rishi, and Zaidat, Osama O.

Published
2019
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32. Impact of Balloon Guide Catheter Use on Clinical and Angiographic Outcomes in the STRATIS Stroke Thrombectomy Registry

Author

Zaidat, Osama O., Mueller-Kronast, Nils H., Hassan, Ameer E., Haussen, Diogo C., Jadhav, Ashutosh P., Froehler, Michael T., Jahan, Reza, Ali Aziz-Sultan, Mohammad, Klucznik, Richard P., Saver, Jeffrey L., Hellinger, Frank R., Jr, Yavagal, Dileep R., Yao, Tom L., Gupta, Rishi, Martin, Coleman O., Bozorgchami, Hormozd, Kaushal, Ritesh, Nogueira, Raul G., Gandhi, Ravi H., Peterson, Eric C., Dashti, Shervin, Given, Curtis A., II, Mehta, Brijesh P., Deshmukh, Vivek, Starkman, Sidney, Linfante, Italo, McPherson, Scott H., Kvamme, Peter, Grobelny, Thomas J., Hussain, Muhammad Shazam, Thacker, Ike, Vora, Nirav, Chen, Peng Roc, Monteith, Stephen J., Ecker, Robert D., Schirmer, Clemens M., Sauvageau, Eric, Chebl, Alex Bou, Derdeyn, Colin P., Maidan, Lucian, Badruddin, Aamir, Siddiqui, Adnan H., Dumont, Travis M., Alhajeri, Abdulnasser, Taqi, Muhammad A., Asi, Khaled, Carpenter, Jeffrey, Boulos, Alan, Jindal, Gaurav, Puri, Ajit S., Chitale, Rohan, Deshaies, Eric M., Robinson, David, Kallmes, David F., Baxter, Blaise W., Jumaa, Mouhammed, Sunenshine, Peter, Majjhoo, Aniel, English, Joey D., Suzuki, Shuichi, Fessler, Richard D., Delgado-Almandoz, Josser, Martin, Jerry C., and Liebeskind, David S.

Published
2019
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33. Oral health and functional outcomes following mechanical thrombectomy for ischemic stroke.

Author

Feldman, Michael J., Koester, Stefan W., Chaliff, Ryan S., Yengo-Kahn, Aaron, Wong, Gunther, Roth, Steven, Longo, Michael, Fusco, Matthew R., Froehler, Michael T., and Chitale, Rohan

Subjects
STATISTICS, ORAL hygiene, TOOTH loss, CONFIDENCE intervals, ORAL health, ISCHEMIC stroke, MULTIVARIATE analysis, RETROSPECTIVE studies, FUNCTIONAL assessment, RISK assessment, STROKE units, THROMBECTOMY, DENTAL pathology, TISSUE plasminogen activator, DISEASE risk factors, DISEASE complications
Abstract

Background An association between poor dentition and the risk of ischemic stroke has previously been reported in the literature. In this study we assessed oral hygiene (OH), including tooth loss and the presence of dental disease, to determine if an association exists with functional outcomes following mechanical thrombectomy (MT) for large-vessel ischemic stroke. Methods A retrospective review was conducted of consecutive adult patients at a single comprehensive stroke center who underwent MT from 2012 to 2018. Inclusion criteria included availability of CT imaging to radiographically assess OH. A multivariate analysis was performed, with the primary outcome being 90-day post-thrombectomy modified Rankin Scale (mRS) score >2. Results A total of 276 patients met the inclusion criteria. The average number of missing teeth was significantly higher in patients with a poor functional outcome (mean (SD) 10 (11) vs 4 (6), p<0.001). The presence of dental disease was associated with poor functional outcome, including cavities (21 (27%) vs 13 (8%), p<0.001), periapical infection (18 (23%) vs 11 (6.7%), p<0.001), and bone loss (27 (35%) vs 11 (6.7%), p<0.001). Unadjusted, missing teeth was a univariate predictor of poor outcome (OR 1.09 (95% CI 1.06 to 1.13), p<0.001). After adjustment for recanalization scores and use of tissue plasminogen activator (tPA), missing teeth remained a predictor of poor outcome (OR 1.07 (95% CI 1.03 to 1.11), p<0.001). Conclusion Missing teeth and the presence of dental disease are inversely correlated with functional independence following MT, independent of thrombectomy success or tPA status. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Flat-panel dual-energy head computed tomography in the angiography suite after thrombectomy for acute stroke: A clinical feasibility study

Author

DiNitto, Julie, primary, Feldman, Michael, additional, Grimaudo, Heather, additional, Mummareddy, Nishit, additional, Ahn, Seoiyoung, additional, Bhamidipati, Akshay, additional, Anderson, Drew, additional, Ramirez-Giraldo, Juan Carlos, additional, Fusco, Matthew, additional, Chitale, Rohan, additional, and Froehler, Michael T, additional

Published
2023
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38. First Pass Effect: A New Measure for Stroke Thrombectomy Devices

Author

Zaidat, Osama O., Castonguay, Alicia C., Linfante, Italo, Gupta, Rishi, Martin, Coleman O., Holloway, William E., Mueller-Kronast, Nils, English, Joey D., Dabus, Guilherme, Malisch, Tim W., Marden, Franklin A., Bozorgchami, Hormozd, Xavier, Andrew, Rai, Ansaar T., Froehler, Michael T., Badruddin, Aamir, Nguyen, Thanh N., Taqi, M. Asif, Abraham, Michael G., Yoo, Albert J., Janardhan, Vallabh, Shaltoni, Hashem, Novakovic, Roberta, Abou-Chebl, Alex, Chen, Peng R., Britz, Gavin W., Sun, Chung-Huan J., Bansal, Vibhav, Kaushal, Ritesh, Nanda, Ashish, and Nogueira, Raul G.

Published
2018
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41. Low Levels of Low-Density Lipoprotein Cholesterol Increase the Risk of Post-Thrombectomy Delayed Parenchymal Hematoma.

Author

Seoiyoung Ahn, Roth, Steven G., Jo, Jacob, Yeji Ko, Mummareddy, Nishit, Fusco, Matthew R., Chitale, Rohan V., and Froehler, Michael T.

Subjects
LDL cholesterol, HDL cholesterol, ISCHEMIC stroke, MAGNETIC resonance imaging, HEMATOMA
Abstract

Purpose: Low levels of low-density lipoprotein cholesterol (LDL-C) have been suggested to increase the risk of hemorrhagic transformation (HT) following acute ischemic stroke. However, the literature on the relationship between LDL-C levels and post-thrombectomy HT is sparse. The aim of our study is to investigate the association between LDL-C and delayed parenchymal hematoma (PH) that was not seen on immediate post-thrombectomy dual-energy computed tomography (DECT). Materials and Methods: A retrospective analysis was conducted on all patients with anterior circulation large vessel occlusion who underwent thrombectomy at a comprehensive stroke center from 2018--2021. Per institutional protocol, all patients received DECT immediately post-thrombectomy and magnetic resonance imaging or CT at 24 hours. The presence of immediate hemorrhage was assessed by DECT, while delayed PH was assessed by 24-hour im- aging. Multivariable analysis was performed to identify predictors of delayed PH. Patients with hemorrhage on immediate post-thrombectomy DECT were excluded to select only those with delayed PH. Results: Of 159 patients without hemorrhage on immediate post-thrombectomy DECT, 18 (11%) developed delayed PH on 24-hour imaging. In multivariable analysis, LDL-C (odds ratio [OR], 0.76; P=0.038; 95% confidence interval [CI], 0.59--0.99; per 10 mg/dL increase) independently predicted delayed PH. High-density lipoprotein cholesterol, triglyceride, and statin use were not associated. After adjusting for potential confounders, LDL-C ≤50 mg/dL was asso- ciated with an increased risk of delayed PH (OR, 5.38; P=0.004; 95% CI, 1.70--17.04), while LDL-C >100 mg/dL was protective (OR, 0.26; P=0.041; 95% CI, 0.07--0.96). Conclusion: LDL-C ≤50 mg/dL independently predicted delayed PH following thrombectomy and LDL-C >100 mg/dL was protective, irrespective of statin. Thus, patients with low LDL-C levels may warrant vigilant monitoring and necessary interventions, such as blood pressure control or anticoagulation management, following thrombectomy even in the absence of hemorrhage on immediate post-thrombectomy DECT. [ABSTRACT FROM AUTHOR]

Published
2023
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44. A multicenter study of the safety and effectiveness of mechanical thrombectomy for patients with acute ischemic stroke not meeting top-tier evidence criteria

Author

Goyal, Nitin, Tsivgoulis, Georgios, Frei, Donald, Turk, Aquilla, Baxter, Blaise, Froehler, Michael T, Mocco, J, Vachhani, Jay, Hoit, Daniel, Elijovich, Lucas, Loy, David, Turner, Raymond D, Mascitelli, Justin, Espaillat, Kiersten, Alexandrov, Andrei V, Alexandrov, Anne W, and Arthur, Adam S

Published
2018
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46. Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke: Primary Results of the STRATIS Registry

Author

Mueller-Kronast, Nils H., Zaidat, Osama O., Froehler, Michael T., Jahan, Reza, Aziz-Sultan, Mohammad Ali, Klucznik, Richard P., Saver, Jeffrey L., Hellinger, Frank R., Jr, Yavagal, Dileep R., Yao, Tom L., Liebeskind, David S., Jadhav, Ashutosh P., Gupta, Rishi, Hassan, Ameer E., Martin, Coleman O., Bozorgchami, Hormozd, Kaushal, Ritesh, Nogueira, Raul G., Gandhi, Ravi H., Peterson, Eric C., Dashti, Shervin R., Given, Curtis A., II, Mehta, Brijesh P., Deshmukh, Vivek, Starkman, Sidney, Linfante, Italo, McPherson, Scott H., Kvamme, Peter, Grobelny, Thomas J., Hussain, Muhammad S., Thacker, Ike, Vora, Nirav, Chen, Peng Roc, Monteith, Stephen J., Ecker, Robert D., Schirmer, Clemens M., Sauvageau, Eric, Abou-Chebl, Alex, Derdeyn, Colin P., Maidan, Lucian, Badruddin, Aamir, Siddiqui, Adnan H., Dumont, Travis M., Alhajeri, Abdulnasser, Taqi, M. Asif, Asi, Khaled, Carpenter, Jeffrey, Boulos, Alan, Jindal, Gaurav, Puri, Ajit S., Chitale, Rohan, Deshaies, Eric M., Robinson, David H., Kallmes, David F., Baxter, Blaise W., Jumaa, Mouhammad A., Sunenshine, Peter, Majjhoo, Aniel, English, Joey D., Suzuki, Shuichi, Fessler, Richard D., Delgado Almandoz, Josser E., Martin, Jerry C., and Haussen, Diogo C.

Published
2017
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47. Blood–brain barrier permeability derangements in posterior circulation ischemic stroke: Frequency and relation to hemorrhagic transformation

Author

Lee, Meng, Saver, Jeffrey L., Alger, Jeffry R., Hao, Qing, Starkman, Sidney, Ali, Latisha K., Kim, Doojin, Ovbiagele, Bruce, Vespa, Paul M., Froehler, Michael T., Tenser, Matthew S., Salamon, Noriko, Villablanca, J. Pablo, Jahan, Reza, Duckwiler, Gary R., Tateshima, Satoshi, Gonzalez, Nestor, Vinuela, Fernando, and Liebeskind, David S.

Published
2012
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48. Time to treatment with bridging intravenous alteplase before endovascular treatment:subanalysis of the randomized controlled SWIFT-DIRECT trial

Author

Meinel, Thomas R, primary, Kaesmacher, Johannes, additional, Buetikofer, Lukas, additional, Strbian, Daniel, additional, Eker, Omer Faruk, additional, Cognard, Christophe, additional, Mordasini, Pasquale, additional, Deppeler, Sandro, additional, Mendes Pereira, Vitor, additional, Albucher, Jean François, additional, Darcourt, Jean, additional, Bourcier, Romain, additional, Guillon, Benoit, additional, Papagiannaki, Chrysanthi, additional, Costentin, Guillaume, additional, Sibolt, Gerli, additional, Räty, Silja, additional, Gory, Benjamin, additional, Richard, Sébastien, additional, Liman, Jan, additional, Ernst, Marielle, additional, Boulanger, Marion, additional, Barbier, Charlotte, additional, Mechtouff, Laura, additional, Zhang, Liqun, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Nikoubashman, Omid, additional, Reich, Arno, additional, Consoli, Arturo, additional, Weisenburger, David, additional, Requena, Manuel, additional, Garcia-Tornel, Alvaro, additional, Saleme, Suzana, additional, Moulin, Solène, additional, Pagano, Paolo, additional, Saliou, Guillaume, additional, Carrera, Emmanuel, additional, Janot, Kevin, additional, Boix, Marti, additional, Pop, Raoul, additional, Della Schiava, Lucie, additional, Luft, Andreas, additional, Piotin, Michel, additional, Gentric, Jean Christophe, additional, Pikula, Aleksandra, additional, Pfeilschifter, Waltraud, additional, Arnold, Marcel, additional, Siddiqui, Adnan, additional, Froehler, Michael T, additional, Furlan, Anthony J, additional, Chapot, René, additional, Wiesmann, Martin, additional, Machi, Paolo, additional, Diener, Hans-Christoph, additional, Kulcsar, Zsolt, additional, Bonati, Leo, additional, Bassetti, Claudio, additional, Escalard, Simon, additional, Liebeskind, David, additional, Saver, Jeffrey L, additional, Fischer, Urs, additional, and Gralla, Jan, additional

Published
2022
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49. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial

Author

Fischer, Urs, primary, Kaesmacher, Johannes, additional, Strbian, Daniel, additional, Eker, Omer, additional, Cognard, Christoph, additional, Plattner, Patricia S, additional, Bütikofer, Lukas, additional, Mordasini, Pasquale, additional, Deppeler, Sandro, additional, Pereira, Vitor M, additional, Albucher, Jean François, additional, Darcourt, Jean, additional, Bourcier, Romain, additional, Benoit, Guillon, additional, Papagiannaki, Chrysanthi, additional, Ozkul-Wermester, Ozlem, additional, Sibolt, Gerli, additional, Tiainen, Marjaana, additional, Gory, Benjamin, additional, Richard, Sébastien, additional, Liman, Jan, additional, Ernst, Marielle Sophie, additional, Boulanger, Marion, additional, Barbier, Charlotte, additional, Mechtouff, Laura, additional, Zhang, Liqun, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Nikoubashman, Omid, additional, Reich, Arno, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, Ribo, Marc, additional, Tomasello, Alejandro, additional, Saleme, Suzana, additional, Macian, Francisco, additional, Moulin, Solène, additional, Pagano, Paolo, additional, Saliou, Guillaume, additional, Carrera, Emmanuel, additional, Janot, Kevin, additional, Hernández-Pérez, María, additional, Pop, Raoul, additional, Schiava, Lucie Della, additional, Luft, Andreas R, additional, Piotin, Michel, additional, Gentric, Jean Christophe, additional, Pikula, Aleksandra, additional, Pfeilschifter, Waltraud, additional, Arnold, Marcel, additional, Siddiqui, Adnan H, additional, Froehler, Michael T, additional, Furlan, Anthony J, additional, Chapot, René, additional, Wiesmann, Martin, additional, Machi, Paolo, additional, Diener, Hans-Christoph, additional, Kulcsar, Zsolt, additional, Bonati, Leo H, additional, Bassetti, Claudio L, additional, Mazighi, Mikael, additional, Liebeskind, David S, additional, Saver, Jeffrey L, additional, Gralla, Jan, additional, Alonso, Angelika, additional, Arquizan, Caroline, additional, Barreau, Xavier, additional, Beaujeux, Rémy, additional, Behme, Daniel, additional, Boeckh-Behrens, Tobias, additional, Boehme, Christian, additional, Boix, Martí, additional, Boulouis, Grégoire, additional, Bricout, Nicolas, additional, Broc, Nicolas, additional, Cereda, Carlo W., additional, Chabert, Emmanuel, additional, Cho, Tae-Hee, additional, Cianfoni, Alessandro, additional, Costalat, Vincent, additional, Denier, Christian, additional, Di Maria, Frederico, additional, du Mesnil de Rochemont, Richard, additional, Fearon, Patricia, additional, Ferrier, Anna, additional, Fischer, Sebastian, additional, Gauberti, Maxime, additional, Gaudron, Marie, additional, Gimenez, Laetitia, additional, Globas, Christoph, additional, Görtler, Michael, additional, Goyal, Mayank, additional, Hilker-Roggendorf, Ruediger, additional, Hill, Michael D., additional, Hua, Vi Tuan, additional, Humbertjean, Lisa, additional, Jansen, Olav, additional, Jung, Simon, additional, Kägi, Georg, additional, Kelly, Michael E., additional, Kleffner, Ilka, additional, Knoflach, Michael, additional, Nedeltchev, Krassen, additional, Krause, Lars Udo, additional, Lappalainen, Kimmo, additional, Lefebvre, Margaux, additional, Leyon, Joe, additional, Liao, Liang, additional, Liegey, Jean-Sebastien, additional, Loehr, Christian, additional, Michel, Patrik, additional, Nannoni, Stefania, additional, Nicholson, Patrick, additional, Nico, Lorena, additional, Obadia, Michael, additional, Ognard, Julien, additional, Ogungbemi, Ayokunle, additional, Olivot, Jean-Marc, additional, Escalard, Simon, additional, Pasi, Marco, additional, Peeling, Lissa, additional, Perez, Jane, additional, Petersen, Martina, additional, Piechowiak, Eike, additional, Raposo, Roberto, additional, Räty, Silja, additional, Reitz, Sarah C., additional, Remollo, Sebastià, additional, Remonda, Luca, additional, Rennie, Ian, additional, Requena, Manuel, additional, Riabikin, Alexander, additional, Riva, Roberto, additional, Rouchaud, Aymeric, additional, Rosi, Andrea, additional, Rubiera, Marta, additional, Spelle, Laurent, additional, Schnieder, Marlena, additional, Schaafsma, Joanna D., additional, Schubert, Tilman, additional, Schulz, Jörg B., additional, Siddiqui, Mohammed, additional, Soize, Sébastien, additional, Sonnberger, Michael, additional, Touze, Emmanuel, additional, Triquenot, Aude, additional, Turc, Guillaume, additional, Vieira, Lucy, additional, Ben Hassen, Wagih, additional, Wagner, Judith N., additional, Wasser, Katrin, additional, Weber, Johannes, additional, Wenz, Holger, additional, Weisenburger-Lile, David, additional, Wodarg, Fritz, additional, Wolff, Valérie, additional, and Wunderlich, Silke, additional

Published
2022
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50. A Phase III, prospective, double-blind, randomized, placebo-controlled trial of thrombolysis in imaging-eligible, late-window patients to assess the efficacy and safety of tenecteplase (TIMELESS): Rationale and design

Author

Albers, Gregory W, primary, Campbell, Bruce CV, additional, Lansberg, Maarten G, additional, Broderick, Joseph, additional, Butcher, Ken, additional, Froehler, Michael T, additional, Schwamm, Lee H, additional, Nouh, Amre M, additional, Liebeskind, David S, additional, Toy, Florence, additional, Yang, Ming, additional, Massaro, Lori, additional, Schoeffler, Megan, additional, and Purdon, Barbara, additional

Published
2022
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