191 results on '"Fraser, DR"'
Search Results
2. Experimental and Numerical Investigation on Thermal Characteristics of 2×3 Designed Battery Module
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Choudhari, Vivek, primary, Dhoble, Ashwinkumar S., additional, Panchal, Satyam, additional, Fowler, Dr. Michael, additional, Fraser, Dr. Roydon, additional, and Panchal, Kirti, additional
- Published
- 2023
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3. Priapism toolbox: facilitating emergency management of ischaemic priapism and improving safety of intracavernosal phenylephrine use
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Shin, Dr. Je Song, primary, Bradley, Dr. Caroline, additional, Jones, Dr. Jennifer, additional, Rewhorn, Dr. Matthew, additional, Vint, Dr. Ross, additional, and Fraser, Dr. Michael, additional
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- 2022
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4. Outcome after surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures and moderate to severe traumatic brain injury (CWIS-TBI)
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Prins, Jonne, van Lieshout, Esther M. M., Ali-Osman, F, Bauman, ZM, Caragounis, EC, Choi, J, Christie, DB, Cole, PA, Devoe, WB, Doben, AR, Eriksson, EA, Forrester, JD, Fraser, DR, Gontarz, B, Hardman, C, Hyatt, DG, Kaye, AJ, Ko, HJ, Leasia, KN, Leon, S, Marasco, SF, McNickle, AG, Nowack, T, Ogunleye, TD, Priya, P, Richman, AP, Schlanser, V, Semon, GR, Su, YH, Verhofstad, Michiel, Whitis, J, Pieracci, FM, Wijffels, Mathieu M. E., Prins, Jonne, van Lieshout, Esther M. M., Ali-Osman, F, Bauman, ZM, Caragounis, EC, Choi, J, Christie, DB, Cole, PA, Devoe, WB, Doben, AR, Eriksson, EA, Forrester, JD, Fraser, DR, Gontarz, B, Hardman, C, Hyatt, DG, Kaye, AJ, Ko, HJ, Leasia, KN, Leon, S, Marasco, SF, McNickle, AG, Nowack, T, Ogunleye, TD, Priya, P, Richman, AP, Schlanser, V, Semon, GR, Su, YH, Verhofstad, Michiel, Whitis, J, Pieracci, FM, and Wijffels, Mathieu M. E.
- Abstract
BACKGROUND: Outcomes after surgical stabilization of rib fractures (SSRF) have not been studied in patients with multiple rib fractures and traumatic brain injury (TBI). We hypothesized that SSRF, as compared with nonoperative management, is associated with favorable outcomes in patients with TBI. METHODS: A multicenter, retrospective cohort study was performed in patients with rib fractures and TBI between January 2012 and July 2019. Patients who underwent SSRF were compared to those managed nonoperatively. The primary outcome was mechanical ventilation-free days. Secondary outcomes were intensive care unit length of stay and hospital length of stay, tracheostomy, occurrence of complications, neurologic outcome, and mortality. Patients were further stratified into moderate (GCS score, 9-12) and severe (GCS score, ≤8) TBI. RESULTS: The study cohort consisted of 456 patients of which 111 (24.3%) underwent SSRF. The SSRF was performed at a median of 3 days, and SSRF-related complication rate was 3.6%. In multivariable analyses, there was no difference in mechanical ventilation-free days between the SSRF and nonoperative groups. The odds of developing pneumonia (odds ratio [OR], 0.59; 95% confidence interval [95% CI], 0.38-0.98; p = 0.043) and 30-day mortality (OR, 0.32; 95% CI, 0.11-0.91; p = 0.032) were significantly lower in the SSRF group. Patients with moderate TBI had similar outcome in both groups. In patients with severe TBI, the odds of 30-day mortality was significantly lower after SSRF (OR, 0.19; 95% CI, 0.04-0.88; p = 0.034). CONCLUSION: In patients with multiple rib fractures and TBI, the mechanical ventilation-free days did not differ between the two treatment groups. In addition, SSRF was associated with a significantly lower risk of pneumonia and 30-day mortality. In patients with moderate TBI, outcome was similar. In patients with severe TBI a lower 30-day mortality was observed. There was a low SSRF-related complication risk. These data suggest a p
- Published
- 2021
5. Social accounting and organisational change: an exploration of the sustainability assessment model
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Fraser, Dr Michael
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- 2011
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6. Pressure Sensing
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Fraser, Dr Peter, primary
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- 2010
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7. The effect of parathyroid hormone on the uptake and retention of 25-hydroxyvitamin D in skeletal muscle cells
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Abboud, M, Rybchyn, MS, Liu, J, Ning, Y, Gordon-Thomson, C, Brennan-Speranza, TC, Cole, L, Greenfield, H, Fraser, DR, and Mason, RS
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Endocrinology & Metabolism ,Mice, Inbred BALB C ,0301 Analytical Chemistry, 0601 Biochemistry and Cell Biology ,Parathyroid Hormone ,Muscle Fibers, Skeletal ,Animals ,Humans ,Vitamin D ,Muscle, Skeletal ,Cells, Cultured ,Cell Line - Abstract
Data from our studies, and those of others, support the proposal that there is a role for skeletal muscle in the maintenance of vitamin D status. We demonstrated that skeletal muscle is able to internalise extracellular vitamin D binding protein, which then binds to actin in the cytoplasm, to provide high affinity binding sites which accumulate 25-hydroxyvitamin D3 (25(OH)D3) [1]. This study investigated the concentration- and time-dependent effects of parathyroid hormone (PTH) on the capacity of muscle cells to take up and release 3H-25(OH)D3. Uptake and retention studies for 3H-25(OH)D3 were carried out with C2C12 cells differentiated into myotubes and with primary mouse muscle fibers as described [1]. The presence of PTH receptors on mouse muscle fibers was demonstrated by immunohistochemistry and PTH receptors were detected in differentiated myotubes, but not myoblasts, and on muscle fibers by Western blot. Addition of low concentrations of vitamin D binding protein to the incubation media did not alter uptake of 25(OH)D3. Pre-incubation of C2 myotubes or primary mouse muscle fibers with PTH (0.1 to 100 pM) for 3h resulted in a concentration-dependent decrease in 25(OH)D3 uptake after 4 or 16h. These effects were significant at 0.1 or 1pM PTH (p
- Published
- 2017
8. COMPARITIVE STUDY OF THE ORGANIZATIONAL STRUCTURE OF ENGINEERING STUDENT TEAMS AND TEAM EFFECTIVENESS
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Kartha, Radhika R., primary, Fowler, Dr Michael W., additional, and Fraser, Dr Roydon A., additional
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- 2018
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9. The Uncertain Oversight of Offshore Aircraft Maintenance: The Case of Australia
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Hampson, I, Junor, AM, Fraser, DR, Quinlan, MG, Hampson, I, Junor, AM, Fraser, DR, and Quinlan, MG
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In the last twenty years, aircraft maintenance outsourcing hasdriven strong growth in the third-party Maintenance Repair and Overhaul (MRO) facility industry. In the United States, deficienciesin safety oversight and regulation have played a role in somemaintenance-related incidents. Since then, Congress wrote legislationto require the Federal Aviation Administration (FAA) toimprove its safety oversight, particularly of offshore facilities.However, there has been no such pressure driving improvementin Australia. Questions have been raised about the poor practicesin some offshore MRO facilities and about the safety oversightof offshored maintenance. This article argues that theexisting system, based on International Civil Aviation Organization(ICAO) standards, cannot provide certainty that the planesof Australian-registered airlines are maintained to best practicestandards. This is for two reasons: the regulations have gaps andenforcement of the regulations leaves much to be desired.
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- 2016
10. The future of aircraft maintenance in Australia: Workforce Capability, Aviation Safety and Industry Development
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Hampson, I, Fraser, DR, Junor, AM, Quinlan, M, Gregson, S, Hampson, I, Fraser, DR, Junor, AM, Quinlan, M, and Gregson, S
- Published
- 2015
11. The Global Food Crisis: Learning from the past to help inform the future
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Fraser, Dr. Evan
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inform ,future ,Global Food Crisis ,Learning ,past - Abstract
A presentation about the global food crisis with the theme of learning from the past to help inform the future. University of Guelph Agri-Food and Rural Link and OMAFRA
- Published
- 2012
12. Effect of low body weight on bone mineral status of pubertal girls in beijing
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Du, XQ, primary, Greenfield, H, additional, Fraser, DR, additional, and Ge, KY, additional
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- 2000
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13. Insulin-like growth factor-1 and other indicators of bone growth in chinese pre-pubertal girls
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Zhu, K, primary, Greenfield, H, additional, Du, XQ, additional, and Fraser, DR, additional
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- 2000
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14. Seasonal vitamin D status of Greyhounds in Sydney
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LAING, CJ, primary, MALIK, R., additional, WIGNEY, DI, additional, and FRASER, DR, additional
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- 1999
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15. The association between dietary protein intake and bone mass accretion in pubertal girls with low calcium intakes.
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Zhang Q, Ma G, Greenfield H, Zhu K, Du X, Foo LH, Hu X, and Fraser DR
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- 2010
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16. Influence of body composition, muscle strength, diet and physical activity on total body and forearm bone mass in Chinese adolescent girls.
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Huat Foo L, Zhang Q, Zhu K, Ma G, Greenfield H, and Fraser DR
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- 2007
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17. Bone mass in Chinese premenarcheal girls: the roles of body composition, calcium intake and physical activity.
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Zhu K, Du X, Greenfield H, Zhang Q, Ma G, Hu X, and Fraser DR
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- 2004
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18. School-milk intervention trial enhances growth and bone mineral accretion in Chinese girls aged 10-12 years in Beijing [corrected] [published erratum appears in BR J NUTR 2005 Apr;93(4):571].
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Du X, Zhu K, Trube A, Zhang Q, Ma G, Hu X, Fraser DR, and Greenfield H
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- 2004
19. Vitamin D deficiency and associated factors in adolescent girls in Beijing.
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Du X, Greenfield H, Fraser DR, Ge K, Trube A, and Wang Y
- Abstract
BACKGROUND: Several locally published reports indicate a high prevalence of vitamin D deficiency among adolescents in China, but no systematic population-based survey has been conducted. OBJECTIVE: The objective was to determine the prevalence of vitamin D deficiency and to study associated factors in adolescent girls in Beijing. DESIGN: A cross-sectional study was conducted in a random sample of 1248 Beijing girls aged 12-14 y. Nutrient intakes, ultraviolet light exposure, anthropometric characteristics, physical activity, signs and symptoms of rickets, and plasma concentrations of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and calcium were measured and X-rays of the hand and wrist were taken. RESULTS: The prevalence of clinical vitamin D and calcium deficiency (plasma 25-hydroxyvitamin D <12.5 nmol/L, plasma calcium <2.25 mmol/L, and muscle spasm at least once per week) was 9.4% in winter. The prevalence of subclinical vitamin D deficiency (25-hydroxyvitamin D <12.5 nmol/L) was 45.2% in winter and 6.7% in summer (P < 0.0005). Logistic regression analysis showed that subclinical and clinical vitamin D deficiency in winter were associated with low plasma 25-hydroxyvitamin D concentrations (<12.5 nmol/L) in summer, low calcium intake ( x +/- SD: 280 +/- 48 compared with 440 +/- 61 mg/d), and low plasma calcium concentrations (<2.25 mmol/L) in winter. The odds ratios for these associations were 3.1, 1.5, and 1.5, respectively. CONCLUSIONS: Subclinical vitamin D deficiency was widespread among Beijing adolescent girls in winter. Low plasma 25-hydroxyvitamin D concentrations in summer, low calcium intake, and low plasma calcium concentrations in winter were the main risk factors for vitamin D deficiency in winter. Copyright © 2001 American Society for Clinical Nutrition [ABSTRACT FROM AUTHOR]
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- 2001
20. Improvement of bone health in childhood and adolescence.
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Kun Z, Greenfield H, Xueqin D, and Fraser DR
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OSTEOPOROSIS ,BONE diseases ,CHILDREN'S health ,ADOLESCENCE - Published
- 2001
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21. Reviewers
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Leicht, Anthony, Dalleck, Lance C, Fraser, Dr Steve, Gillam, Ian, Guelfi, Kym, Marsh, Susan A, and McNaughton, Lars
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- 2014
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22. Vitamin D Esters: Non-specific Storage Form of Vitamin D in the Rat
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Fraser Dr
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Liver metabolism ,Vitamin D metabolism ,Biochemistry ,Non specific ,Chemistry ,Vitamin D and neurology ,Kidney metabolism ,Cholecalciferol metabolism - Published
- 1969
23. I: Part I.: PRELIMINARY REPORT OF THE COMMISSION ON THE SEA-LION QUESTION, 1915
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Newcombe, Dr. Charles P., Greenwood, W.-M. Hamar, and Fraser, Dr. C. McLean
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n/a
- Published
- 1917
24. Research priorities in the field of vitamin deficiency in man
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Bamji, MS, primary, Brubacher, GB, additional, DeLuca, HF, additional, Fraser, DR, additional, Sauberlich, HE, additional, and Spirichev, VB, additional
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- 1979
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25. Lost & Found: 206. Cambridge Greensand vertebrate fossils
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Fraser, Dr. Nicholas, primary
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- 1989
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26. I: Part I.: PRELIMINARY REPORT OF THE COMMISSION ON THE SEA-LION QUESTION, 1915.
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Newcombe, Dr. Charles P., primary, Greenwood, Wm. Hamar, additional, and Fraser, Dr. C. McLean, additional
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- 1917
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27. Exploration of possible mechanisms linking vitamin D status and dietary calcium to prostate cancer.
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Fraser DR
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- 2007
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28. Effects of school-milk intervention on growth and bone mineral accretion in Chinese girls aged 10-12 years: accounting for cluster randomisation.
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Du X, Zhu K, Trube A, Fraser DR, Greenfield H, Zhang Q, Ma G, and Hu X
- Published
- 2005
29. Effects of two years' milk supplementation on size-corrected bone mineral density of Chinese girls.
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Zhu K, Greenfield H, Du X, Zhang Q, Ma G, Hu X, Cowell CT, Fraser DR, Zhu, Kun, Greenfield, Heather, Du, Xueqin, Zhang, Qian, Ma, Guansheng, Hu, Xiaoqi, Cowell, Chris T, and Fraser, David R
- Abstract
Much existing data on the effects of calcium or milk products on bone mineral accretion are based on bone mineral content (BMC) or areal bone mineral density (aBMD), neither of which accounts for changing bone size during the growing period. The aim of this study was to investigate the effects of 2-year milk supplementation on total body size-corrected BMD in Chinese girls with low habitual dietary calcium intake. Chinese girls aged 10 years were randomised, according to their school, to receive calcium fortified milk (Ca milk), or calcium and vitamin D fortified milk (CaD milk) for two years or act as unsupplemented controls. Dual-energy X-ray absorptiometry total body bone measures were obtained from 345 girls at baseline and 2 years. Size-corrected total body and regional BMD was calculated as: BMDsc = BMC/BApc, where pc was the regression coefficient of the natural logarithm transformed total body BMC and bone area. After 2 years, both supplemented groups had significantly greater gain in BMDsc of total body (3.5-5.8%, p < 0.05) and legs (3.0-5.9%, p < 0.05) than did the control group. Milk supplementation showed positive effects on bone mineral accretion when accounting for the changing skeletal size during growth. The effects were mainly on the lower limbs. [ABSTRACT FROM AUTHOR]
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- 2008
30. Factors Affecting Georgian Bay Coastal Wetlands
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Cvetkovic, Maja, Chow-Fraser, Dr. Patricia, and Biology
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coastal wetlands ,macrophyte ,fish distribution ,Georgian Bay - Abstract
Coastal wetlands of Georgian Bay have been virtually ignored by ecologists until recently, when these ecosystems were found to have exceptionally high biodiversity compared to other Gr,~at Lakes wetlands. To address this deficiency, we conducted a baseline survey (2002 to 2007) to determine the biotic and abiotic characteristics of 92 wetlands in 18 quatemary watersheds, using a suite of published ecological indices developed specifically for coastal wetlands (Water Quality Index (WQI); adjusted Wetland Macrophyte Index (WMiadj), and the Wetland Fish IndexBasinPAex (WFIBasinPAex)). Although a majority of the watersheds are located in remote eastern and northern parts of the Bay and therefore receive minimal human disturbance, one watershed, Sturgeon River, located in southern Georgian Bay receives relatively high urban, recreational and agricultural disturbance. Mean scores of WQI and WMiadj varied significantly across the watersheds, ranging from 0.48 to 2.15, and from 2.29 to 3.77, respectively. Mean WFIBasinPAex scores, however, were less variable and only ranged from 3.53 to 3.86. Of the 88 macrophyte species identified, the most common were hardstem bulrush. (Schoenoplectus acutus), water celery (Vallisneria americana), richardson's pondweed (Potamogeton richardsonii), slender waternymph (Najasjlexilis) and Canadian waterweed (Elodea canadensis). Six non-native macrophytes, Purple loosestrife (Lythrum wlicaria), narrow-leaf cattail (Typha angustifolia), hybrid cattail (Typha x glauca), Eurasian milfoil (Myriophyllum spicatum), curly pondweed (Potamogeton crispw) and frogbit (Hydrocharus morsus-ranae) were also recorded, the most common ofwhieh was Eurasian milfoil. Sago pondweed (Stuckenia pectinata), a native species that can be invasive, and is tolerant of poor water-quality, was present in about half of the watersheds. Ofthe 51 fish species, pumpkinseed (Lepomis gibbosus) bluntnose minnow (Pfmephales notatus), brown bullhead (Ameiurus nebulosus), rock bass (Ambloplites rupestris), and yellow perch (Percajlavescens) were the most widespread and abundant. Three non-native species, common carp (Cyprinus carpio), alewife (Alosa pesudoharengus), and round goby (Neogobius melanostomus) were present but not dominant. WMI scores were highly correlated with WQI scores, and as expected, wetlands in the most disturbed southern watershed were associated with the lowest WQI and WM[ scores, and had the greatest number of exotic species. However, WMI scores of wetlands in a few exposed sites located at the tip of the Bruce Peninsula were similarly low, even though these sites are not yet impacted by human activities. There was no significant relationship between WFIBasinPAand WQI scores, although the WFIBasin PA did not seem to be affected by exposure. We recommend that the WQI and WMiadj be used in long-term monitoring programs of Georgian Bay to track negative impacts of human disturbance on these valuable ecosystems. Thesis Master of Science (MS)
- Published
- 2008
31. Predictions Concerning Internal Phosphorus Release in Cootes Paradise Marsh and Implications for Restoration
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Kelton, Nadia, Chow-Fraser, Dr. Patricia, and Biology
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restoration ,internal phosphorus release ,cootes paradise - Abstract
To assess the relative contribution of phosphorus release from sediment in Cootes Paradise Marsh, I first examined spatial and temporal variability of laboratory-measured release rates from sediment samples collected from 12 sites within the wetland (Chapter 1 ). The microbial communities from these 12 sites were characterized on the basis of sole-carbon-source utilization using BIOLOG GN plates containing 95 substrates. Results from these experiments were entered into a principal component analysis and the release rates for all sites were regressed against corresponding PC 1 and PC2 scores (Chapter 2). Differences in microbial physiology as defined by PC 1 and PC2 scores accounted for 49% and 53%, respectively of the variation in phosphorus release rates. Using stepwise multiple regression, I concluded that the key determinants of laboratory-derived release rates from West Pond sediment (a highly eutrophic site within Cootes Paradise Marsh) are oxic state, ambient temperature and time of sediment collection (Chapter 3). Using this information I developed a multivariate model to predict release rates. This model, along with 2 alternative approaches, was used to estimate the extent of internal loading (kg d-1) in Cootes Paradise Marsh (Chapter 4). Method 1 was a highly controlled, static approach and resulted in an internal load of 11 .6 kg d-1, which was attributed to diffusion. The remaining two methods were more dynamic in nature as they took into account temporal variation, ambient temperature and the development of anoxia. Using Method 2, I estimated an internal load of 7.8 to 8.5 kgd-1, which was based on empirically-derived laboratory release rates. Method 3 consisted of the predictive model from which I estimated an internal load of 6.7 kgd-1• I attributed the release from the latter two methods to microbial mineralization processes. Based on this work and a previous estimate of internal loading in Cootes Paradise Marsh (Prescott & Tsanis 1997), I concluded that mineralization accounts for 22.3% of total phosphorus loading to the system, preceded only by urban runoff ( 41% ). Thesis Master of Science (MS)
- Published
- 2001
32. Short communication: Metabolic synthesis of vitamin D 2 by the gut microbiome.
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Chaves AV, Rybchyn MS, Mason RS, and Fraser DR
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- Animals, Cattle, Sheep microbiology, Mice, Gastrointestinal Microbiome, Gastrointestinal Tract metabolism, Gastrointestinal Tract microbiology, Fermentation, Rumen microbiology, Rumen metabolism, Ergocalciferols metabolism
- Abstract
The origin of vitamin D
2 in herbivorous animals was investigated in vivo in sheep and in bovine as well as mouse gastrointestinal tracts. A high concentration of 25-hydroxyvitamin D2 in blood plasma of sheep both in summer and winter appeared to be incompatible with the undetectable level of vitamin D2 in the pasture on which the sheep were grazing. Studies with bovine rumen contents from a cow grazing the same pasture as the sheep, demonstrated an increased concentration of vitamin D2 on anaerobic incubation in a 'Rusitec' artificial rumen, which was further enhanced when cellulose powder was added as a fermentation substrate. The colon contents of mice that were fed from weaning on a vitamin D-free diet were found to contain vitamin D2 . The results of these comparative studies in 3 animal species indicated that vitamin D2 was being generated by microbial anaerobic metabolism in the gastrointestinal tract., Competing Interests: Declaration of competing interest The authors have no competing interests to declare., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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33. Trauma Laparoscopy: Time Efficient, Cost Effective, and Safe.
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Dorricott AR, Dickinson A, McNickle AG, Batra K, Flores CE, Fraser DR, and Chestovich PJ
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- Humans, Retrospective Studies, Female, Male, Adult, Middle Aged, Postoperative Complications economics, Postoperative Complications etiology, Postoperative Complications epidemiology, Hospital Charges statistics & numerical data, Wounds, Nonpenetrating surgery, Wounds, Nonpenetrating economics, Wounds, Nonpenetrating diagnosis, Wounds, Penetrating surgery, Wounds, Penetrating economics, Wounds, Penetrating diagnosis, Hospital Costs statistics & numerical data, Young Adult, Laparoscopy economics, Laparoscopy adverse effects, Laparoscopy statistics & numerical data, Length of Stay statistics & numerical data, Length of Stay economics, Abdominal Injuries surgery, Abdominal Injuries economics, Abdominal Injuries diagnosis, Operative Time, Cost-Benefit Analysis
- Abstract
Introduction: Laparoscopy has demonstrated improved outcomes in abdominal surgery; however, its use in trauma has been less compelling. In this study, we hypothesize that laparoscopy may be observed to have lower costs and complications with similar operative times compared to open exploration in appropriately selected patients., Methods: We retrospectively reviewed adult patients undergoing abdominal exploration after blunt and penetrating trauma at our level 1 center from 2008 to 2020. Data included mechanism, operative time, length of stay (LOS), hospital charges, and complications. Patients were grouped as follows: therapeutic and nontherapeutic diagnostic laparoscopy and celiotomy. Therapeutic procedures included suture repair of hollow viscus organs or diaphragm, evacuation of hematoma, and hemorrhage control of solid organ or mesenteric injury. Unstable patients, repair of major vascular injuries or resection of an organ or bowel were excluded., Results: Two hundred ninety-six patients were included with comparable demographics. Diagnostic laparoscopy had shorter operative times, LOS, and lower hospital charges compared to diagnostic celiotomy controls. Similarly, therapeutic laparoscopy had shorter LOS and lower hospital costs compared to therapeutic celiotomy. The operative time was not statistically different in this comparison. Patients in the celiotomy groups had more postoperative complications. The differences in operative time, LOS and hospital charges were not statistically significant in the diagnostic laparoscopy compared to diagnostic laparoscopy converted to diagnostic celiotomy group, nor in the therapeutic laparoscopy compared to the diagnostic laparoscopy converted to therapeutic laparoscopy group., Conclusions: Laparoscopy can be used safely in penetrating and blunt abdominal trauma. In this cohort, laparoscopy was observed to have shorter operative times and LOS with lower hospital charges and fewer complications., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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34. A Pediatric Brain Injury Guideline Allows Safe Management of Traumatic Brain Injuries by Trauma Surgeons.
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McNickle AG, Bailey D, Yacoub M, Chang S, and Fraser DR
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- Humans, Child, Preschool, Child, Male, Female, Infant, Adolescent, Tomography, X-Ray Computed, Guideline Adherence statistics & numerical data, Retrospective Studies, Registries, Neurosurgical Procedures standards, Neurosurgical Procedures methods, Skull Fractures surgery, Skull Fractures diagnostic imaging, Brain Injuries, Traumatic therapy, Brain Injuries, Traumatic surgery, Practice Guidelines as Topic
- Abstract
Background: We implemented a pediatric Brain Injury Guideline (pBIG) to stratify traumatic brain injuries (TBI) and allow management of less severe cases without repeat CT imaging or neurosurgical consultation. Injuries were classified as mild (pBIG1), moderate (pBIG2), severe (pBIG3) or isolated skull fracture (ISF) based on neurologic status, size and number of bleeds. We hypothesize that pediatric TBIs can be safely managed with this guideline., Methods: Isolated TBIs (<18 years) were queried from the Pediatric Trauma Registry after pBIG implementation from July 2021-March 2023. Datasets included age, injury specifics, repeat head CTs, neurosurgical consultations and interventions. Analysis was performed with Stata, with significance set at p < 0.05., Results: A total of 139 children with a median age of 2.8 years were included. Skull fractures (113, 81%) and subdural hematomas (54, 39%) were the most common injuries. Repeat head CTs were obtained in 44 (32%) and neurosurgical consultation in 89 (64%). Overall guideline compliance was 83.5%, with best performance in the pBIG3 category (96%). One pBIG1 patient had increasing symptoms requiring upgrade, neurosurgical consultation and repeat head CT, but no intervention. Five children (3.6%; 4 isolated skull fracture, 1 pBIG3) had post-discharge ED visits and 1 (0.7%, ISF) had a post-discharge CT. Three (2.2%) children, all in the pBIG3 group, died from their TBIs., Conclusions: Adherence to the algorithm was 83.5%, with the lowest compliance in the moderate TBI (pBIG2) category. This group had a high rate of neurosurgical consultation suggesting uneasiness with independent management of moderate injuries when compared to minor TBIs or isolated skull fracture. Outcomes with the use of the pBIG algorithm were otherwise acceptable., Level of Evidence: Level IV, Therapeutic/Care Management., Competing Interests: Conflict of interest There are no conflicts of interest with this work., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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35. From Admission to Discharge-A Total Friction Burn Review from a Single Institution.
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Estrada Munoz OI, Sabour AF, Carroll JT, Flores CE, Fraser DR, Chestovich P, and Saquib SF
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- Humans, Male, Retrospective Studies, Adult, Female, Length of Stay statistics & numerical data, Patient Discharge, Burn Units, Middle Aged, Hospitalization, Burns therapy, Skin Transplantation, Friction
- Abstract
While most friction burns are adequately managed in an outpatient setting, many may require hospital admission, operative excision, and extended care. To this day, there is a wide variance in friction burn management. Our goal is to review the etiology, management, and outcomes of such burns warranting hospitalization. We conducted a retrospective review of all friction burns admitted to a single, American Burn Association-verified burn center from January 1, 2016 to December 31, 2020. A total of 28 (34%) patients required surgery for their friction burns and 15 (18%) ultimately required a split-thickness skin graft. The mean number of operations was 2.4 (95% CI 1.6-3.1). Overall, the operative group was younger (29.9 vs 38.3 years, P = .026), more likely to have a concomitant traumatic brain injury (25% vs 7%, P = .027), and had a longer hospital length of stay (17.5 vs 3.9 days, P < .001). Both groups had a similar overall TBSA (8.5% vs 10.0%, P = .35), but the operative group had a larger surface area comprised of third-degree burns (3.05% vs 0.2%, P < .001). Overall, friction burns resulting in hospital admission are associated with high-energy traumatic mechanisms and concomitant injuries. Patients who need operative intervention for their burns typically require multiple procedures often culminating in a split-thickness skin graft. While non-operative management of friction burns with topical agents has been found to be successful, patients with higher injury severity scores should be monitored very closely as they may require surgical excision., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Burn Association. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
- Published
- 2024
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36. Early Versus Late Feeding After Percutaneous Endoscopic Gastrostomy Placement in Trauma and Burn.
- Author
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Elks W, McNickle AG, Kelecy M, Batra K, Wong S, Wang S, Angotti L, Kuhls DA, St Hill C, Saquib SF, Chestovich PJ, and Fraser DR
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- Humans, Burns surgery, Retrospective Studies, Time Factors, Wounds and Injuries surgery, Enteral Nutrition methods, Gastrostomy
- Abstract
Introduction: Timing to resume feeds after percutaneous endoscopic gastrostomy (PEG) placement continues to vary among US trauma surgeons. The purpose of this study was to assess differences in meeting nutritional therapy goals and adverse outcomes with early versus late enteral feeding after PEG placement., Methods: This retrospective review included 364 trauma and burn patients who underwent PEG placement. Data included patient characteristics, time to initiate feeds, rate feeds were resumed, % feed volume goals on postoperative days 0-7, and complications. Statistical analysis was performed comparing two groups (feeds ≤ 6 h versus > 6 h) and three subgroups (< 4 h, 4-6 h, ≥ 6 h) based on data quartiles. Chi-square/Fisher's exact test, independent-samples t-test, and one-way analysis of variance were used to analyze the data., Results: Mean time to initiate feeds after PEG was 5.48 ± 4.79 h. Burn patients received early feeds in a larger proportion. A larger proportion of trauma patients received late feeds. The mean % of goal feed volume met on postoperative day 0 was higher in the early feeding group versus the late (P < 0.001). There were no differences in adverse events, even after subgroup analysis of those who received feeds < 4 h after PEG placement., Conclusions: Patients with early initiation of feeds after PEG placement achieve a higher percentage of goals on day 0 without an increased rate of adverse events. Unfortunately, patients routinely fall short of their target tube feeding goals., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2024
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37. Understanding Factors Influencing Decision Making by State Health Officials in a Public Health Emergency.
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Barishansky RM and Fraser MR
- Subjects
- Humans, Qualitative Research, Decision Making, Emergencies, Public Health, COVID-19 epidemiology
- Abstract
State and territorial health officials (STHOs) play a critical role in leading public health emergency response in their respective states. Through an exploratory qualitative study with 21 current or former STHOs, we sought to understand the issues that impact STHO decision making in public health responses. Initial findings suggest the need for structured decision making tools for use by leaders responding to public health emergencies, including COVID-19. Such tools could lead to more systematic responses by STHOs during public health crises., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
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38. Non-operative management strategy for blunt pulmonary artery pseudoaneurysm: A case report.
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Feery DA, Kuruvilla K, McNickle AG, and Fraser DR
- Abstract
Traumatic pulmonary artery pseudoaneurysms (PAP) are rare findings and are often associated with penetrating trauma to the chest. We present a case of a pulmonary artery pseudoaneurysm following blunt trauma. A 49-year-old man presented after a motor vehicle collision. Contrast enhanced computed tomography scans of the neck, chest, abdomen, and pelvis were obtained demonstrating a proximal right pulmonary artery pseudoaneurysm, small volume hemopericardium, left first rib fracture, and focal non-flow limiting dissection of left subclavian artery. For the management of right PAP, we adopted a non-operative management strategy with an esmolol infusion for strict heart rate and blood pressure control. An echocardiogram was obtained the next day revealing no cardiac tamponade. Angiography of the chest was done after 24 h which showed stable appearance of the right PAP and hemopericardium. Patient was discharged home on hospital day 11., Competing Interests: None. The authors declare no conflicts of interest but would like to recognize that the publication fees for this article were supported by the Kirk Kerkorian School of Medicine Library Open Article Fund., (© 2023 The Authors. Published by Elsevier Ltd.)
- Published
- 2023
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39. Shot through the heart: A 17-year analysis of pre-hospital and hospital deaths from penetrating cardiac injuries.
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McNicoll CF, McNickle AG, Vanderet D, Patel PP, Souchon P, Kuhls DA, Fraser DR, and Chestovich PJ
- Subjects
- Humans, Young Adult, Adult, Middle Aged, Hospitals, Retrospective Studies, Wounds, Gunshot, Wounds, Penetrating, Wounds, Stab, Heart Injuries surgery
- Abstract
Background: Penetrating cardiac injuries (PCI) are often fatal despite rapid transport and treatment in the prehospital setting. Although many studies have identified risk factors for mortality, few studies have included non-transported field mortalities. This study analyzes penetrating cardiac injuries including hospital and coroner reports in the current era., Methods: Seventeen years of data were reviewed, including the trauma center (TC) registry, medical records, and coroner reports from 2000-2016. PCI were graded using American Association for the Surgery of Trauma (AAST) cardiac organ injury score (COIS). Subjects were divided into three groups: field deaths, hospital deaths, and survivors to hospital discharge. The primary outcome is survival to hospital discharge overall and among those transported to the hospital., Results: During the study period, 643 PCI patients were identified, with 52 excluded for inadequate data, leaving 591 for analysis. Mean age was 38.1 ± 17.5 years, and survivors (n=66) were significantly younger than field deaths (n=359) (32.6 ± 14.4 vs 41.1 ± 18.5, p<0.001). Stab wounds had higher survival than gunshot wounds (26.6% vs. 4.3%, p<0.001). COIS grades 4 to 6 (n=602) had lower survival than grades 1 to 3 (n=41) (8.3% vs. 39.0%, p<0.001). Survivors (n=66) had lower median COIS than patients who died in hospital (n=218) (4 vs. 5, p<0.001). Single chamber PCI had higher survival than multiple chamber PCI (13% vs. 5%, p=0.004). The left ventricle is the most injured (n=177), and right ventricle PCI has the highest survival (p<0.001). Of field deaths, left ventricular injuries had the highest single chamber mortality (60%), equaling multi-chamber PCI (60%)., Conclusions: Survival to both TC evaluation and hospital discharge following PCI is influenced by many factors including age, mechanism, anatomic site, and grade. Despite advances in trauma care, survival has not appreciably improved., Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare for this work., (Copyright © 2023. Published by Elsevier Ltd.)
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- 2023
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40. A Pediatric Cervical Spine Clearance Guideline Leads to Fewer Unnecessary Computed Tomography Scans and Decreased Radiation Exposure.
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Douglas GP, McNickle AG, Jones SA, Dugan MC, Kuhls DA, Fraser DR, and Chestovich PJ
- Subjects
- Child, Humans, Retrospective Studies, Cervical Vertebrae diagnostic imaging, Cervical Vertebrae injuries, Tomography, X-Ray Computed adverse effects, Tomography, X-Ray Computed methods, Radiation Exposure prevention & control, Spinal Injuries diagnosis, Neck Injuries complications, Wounds, Nonpenetrating complications
- Abstract
Objectives: Physical examination and computed tomography (CT) are useful to rule out cervical spine injury (CSI). Computed tomography scans increase lifetime cancer risk in children from radiation exposure. Most CSI in children occur between the occiput and C4. We developed a cervical spine (C-spine) clearance guideline to reduce unnecessary CTs and radiation exposure in pediatric trauma patients., Methods: A pediatric C-spine clearance guideline was implemented in September 2018 at our Level 2 Pediatric Trauma Center. Guidance included CT of C1 to C4 to scan only high-yield regions versus the entire C-spine and decrease radiation dose. A retrospective cohort study was conducted comparing preguideline and postguideline of all pediatric trauma patients younger than 8 years screened for CSI from July 2017 to December 2020. Primary endpoints included the following: number of full C-spine and C1 to C4 CT scans and radiation dose. Secondary endpoints were CSI rate and missed CSI. Results were compared using χ 2 and Wilcoxon rank-sum test with P < 0.05 significant., Results: The review identified 726 patients: 273 preguideline and 453 postguideline. A similar rate of total C-spine CTs were done in both groups (23.1% vs 23.4%, P = 0.92). Full C-spine CTs were more common preguideline (22.7% vs 11.9%, P < 0.001), whereas C1 to C4 CT scans were more common post-guideline (11.5% vs 0.4%, P < 0.001). Magnetic resonance imaging utilization and CSIs identified were similar in both groups. The average radiation dose was lower postguideline (114 vs 265 mGy·cm -1 ; P < 0.001). There were no missed CSI., Conclusions: A pediatric C-spine clearance guideline led to increasing CT of C1 to C4 over full C-spine imaging, reducing the radiation dose in children., Level of Evidence: Level IV, therapeutic., Competing Interests: Disclosure: The authors declare no conflict of interest., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
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41. Serum 1,25-dihydroxyvitamin D levels in the diagnosis and pathogenesis of nutritional rickets - a multivariable re-analysis of a case-control study.
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Fischer PR, Sempos CT, Pettifor JM, Fraser DR, Munns CF, Durazo-Arvizu RA, and Thacher TD
- Subjects
- Child, Humans, Calcium, Dietary, Case-Control Studies, Vitamin D, Parathyroid Hormone, Calcium, Rickets etiology
- Abstract
Background: A multivariable logistic regression model resulting from a case-control study of nutritional rickets in Nigerian children suggested that higher levels of serum 25(OH)D may be required to prevent nutritional rickets in populations with low-calcium intakes., Objectives: This current study evaluates if adding serum 1,25-dihydroxyvitamin D [1,25(OH)
2 D] to that model shows that increased levels of serum 1,25(OH)2 D are independently associated with risk of children on low-calcium diets having nutritional rickets., Methods: Multivariable logistic regression analysis was used to model the association between serum 1,25(OH)2 D and risk of having nutritional rickets in cases (n = 108) and controls (n = 115) after adjusting for age, sex, weight-for age z-score, religion, phosphorus intake and age began walking and the interaction between serum 25(OH)D and dietary calcium intake (Full Model)., Results: Serum 1,25(OH)2 D levels were significantly higher (320 pmol/L vs. 280 pmol/L) (P = 0.002), and 25(OH)D levels were lower (33 nmol/L vs. 52 nmol/L) (P < 0.0001) in children with rickets than in control children. Serum calcium levels were lower in children with rickets (1.9 mmol/L) than in control children (2.2 mmol/L) (P < 0.001). Dietary calcium intakes were similarly low in both groups (212 mg/d) (P = 0.973). In the multivariable logistic model, 1,25(OH)2 D was independently associated with risk of having rickets [coefficient = 0.007 (95% confidence limits: 0.002-0.011)] after adjusting for all variables in the Full Model., Conclusions: Results confirmed theoretical models that in children with low dietary calcium intake, 1,25(OH)2 D serum concentrations are higher in children with rickets than in children without rickets. The difference in 1,25(OH)2 D levels is consistent with the hypothesis that children with rickets have lower serum calcium concentrations which prompt the elevation of PTH levels resulting in an elevation of 1,25(OH)2 D levels. These results support the need for additional studies to identify dietary and environmental risks for nutritional rickets., (Copyright © 2023 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
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42. BIG Kids: Application of a modified brain injury guideline in a pediatric trauma center.
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McNickle AG, Jones SA, Yacoub M, Streit SM, Bailey D, Ari JB, and Fraser DR
- Subjects
- Adult, Humans, Child, Child, Preschool, Trauma Centers, Tomography, X-Ray Computed, Retrospective Studies, Glasgow Coma Scale, Brain Injuries, Brain Injuries, Traumatic, Skull Fractures
- Abstract
Background: Brain Injury Guidelines (BIG) were developed to stratify traumatic brain injuries (TBIs) by severity to decrease unnecessary CT imaging and neurosurgical consultation in low-risk cases. This study evaluated the potential effect of a modified pediatric BIG (pBIG) algorithm would have on resource utilization., Methods: Isolated TBIs (<18 years) were queried from our Pediatric Trauma Registry from 2017 to 2020. Injuries were classified as mild (pBIG 1), moderate (pBIG 2), or severe (pBIG 3) based on neurologic status, skull fractures, size, and the number of bleeds. Modifications from the institutional adult algorithm were upgrading <4 mm epidural hematomas to pBIG 2 and eliminating interfacility transfer as a pBIG 2 criteria. The proposed pBIG 1 and 2 care plans do not include routine repeat CTs or neurosurgical consultation., Results: A total of 314 children with a mean age of 4.9 years were included. Skull fractures (213, 68%) and subdural hematomas (162, 52%) were the most common injuries. 89 (28%) children had repeat head CTs (2 (7%) pBIG 1, 26 (25%) pBIG 2, 61 (34%) pBIG 3). Neurosurgical consultation was obtained in 306 (98%), with 50 (16%) requiring intervention (1 (1%) pBIG 2 and 49 (27%) pBIG 3). Following the proposed pBIG would decrease neurosurgical consults to 181 (58%) and repeat CTs to 63 (20%). Following the algorithm, 91 (29%) kids would have been admitted to a higher level of care and 45 (14.3%) to a lower level., Conclusions: Implementation of our pBIG algorithm would decrease neurosurgery consults (40% reduction) and repeat head CTs (29% reduction)., Competing Interests: Conflict of Interest There are no conflicts of interest with this work., (Copyright © 2022. Published by Elsevier Inc.)
- Published
- 2023
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43. Differences in career paths of alumni of the Cornell Leadership Program from North American universities compared with those alumni from universities in other countries.
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Fraser DR, Parker JSL, and McGregor DD
- Subjects
- Animals, Humans, Universities, Canada, Schools, Veterinary, Career Choice, Leadership, Students
- Abstract
Objective: To characterize and compare the careers of alumni of the Cornell Leadership Program for Veterinary Students according to the countries where they studied and obtained their veterinary qualification. The Cornell Leadership Program is a 10-week residential research experience program for veterinary students from around the world who have ambitions for research-related careers., Sample: Data on the career development of all 672 alumni were collected each year over the period of 1990 to 2019., Procedures: The annual career profile of each alumnus was recorded and coded in 1 of 28 different categories. The careers and postveterinary qualifications of alumni from universities in the US and Canada (referred to as North American universities) were compared with those alumni who graduated from universities in other countries., Results: Analysis of this 30-year database revealed that a considerable proportion (45.7% [307/672]) of the total 672 alumni are following the traditional career path of veterinary clinical practice rather than the research-related careers they aspired to as students during the Leadership Program. Furthermore, a higher proportion of the 325 North American alumni (56% [182/325]) were in clinical practice compared with 33.6% (112/333) of the 333 alumni from other countries., Clinical Relevance: Many veterinary schools now provide research experience programs to encourage highly talented students who have ambitions for careers in which they can advance knowledge about animal disease and contribute to solving the health problems of animals through hypothesis-based research. Comparison of the careers of the Leadership Program alumni indicates that research experience alone is not sufficient to maintain the career goals of alumni. Follow-up mentoring of alumni of such programs is recommended while they complete their veterinary studies to reinforce their career aspirations and provide advice on how to achieve research-related careers.
- Published
- 2023
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44. Critical asthma syndrome in trauma patients - A case report and literature review.
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Chen C, Sharma R, Singh A, Fraser DR, and Kilburn J
- Abstract
Critical asthma syndrome (CAS) is an umbrella term for many acute, life-threatening, and treatment resistant variants of asthma exacerbation, including refractory asthma, near fatal asthma, and status asthmaticus. The asthma mortality rate has steadily increased through the last decade and disproportionately affects women, African-Americans, patients of low socioeconomic status, and adults over the age of 55. Increased awareness of the diagnosis and therapies for CAS can help establish a therapeutic strategy for asthma beyond corticosteroids, bronchodilators, and other conventional treatments. A 37 year-old African American woman presented to our Level 1 Trauma Center after a high-speed motor vehicle crash and was intubated on arrival for airway protection. The patient developed diffuse wheezing and persistent tachycardia, with elevated peak airway pressures and air trapping on mechanical ventilation. Her symptoms were refractory to inhaled steroids, systemic steroids, intravenous magnesium, continuous albuterol administration and ventilator optimization. Heliox, an admixture of 80:20 percent helium to oxygen, was initiated to assist with laminar flow. Throughout the next 24 h, the patient's air trapping improved, subsequently decreasing intrathoracic pressure, improving venous return and resolving her tachycardia. The patient's multiple orthopedic injuries were treated and she was eventually weaned off of Heliox, steroids, and continuous albuterol. She was extubated and endorsed a history of poorly controlled asthma requiring hospitalizations and multiple intubations. Recognition of CAS can be challenging in the trauma patient with distracting injuries. This case illustrates the utility of a stepwise approach to a trauma patient suffering from CAS, and should encourage further research into novel therapies when conventional treatment fails. Given that the populations most affected by CAS are often also subject to a disproportionate burden of trauma, trauma surgeons should maintain both a vigilance for the syndrome as well as a working knowledge of the treatment modalities available., (© 2022 The Authors. Published by Elsevier Ltd.)
- Published
- 2022
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45. The Volume of Thoracic Irrigation Is Associated With Length of Stay in Patients With Traumatic Hemothorax.
- Author
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Crankshaw L, McNickle AG, Batra K, Kuhls DA, Chestovich PJ, and Fraser DR
- Subjects
- Adult, Chest Tubes, Humans, Length of Stay, Retrospective Studies, Thoracostomy adverse effects, Treatment Outcome, Hemothorax etiology, Hemothorax therapy, Thoracic Injuries complications, Thoracic Injuries therapy
- Abstract
Introduction: Irrigation of the thoracic cavity at tube thoracostomy (TT) placement may decrease the rate of a retained hemothorax (RHTX); however, other resource utilization outcomes have not yet been quantified. This study evaluated the association of thoracic irrigation during TT with the length of stay and outcomes in patients with traumatic hemothorax (HTX)., Methods: A retrospective chart review was performed of adult patients receiving a TT for HTX at a single, urban Level 1 Trauma Center from January 2019 to December 2020. Those who underwent irrigation during TT at the discretion of the trauma surgeon were compared to a control of standard TT without irrigation. Death within 30 d, as well as TTs, placed at outside hospitals, during traumatic arrest or thoracic procedures, and for isolated pneumothoraces were excluded. The primary outcome was the length of stay as hospital-free, ICU-free, and ventilator-free days (30-day benchmark). Subgroup analysis by irrigation volume was conducted using one-way ANOVA testing with P < 0.05 considered statistically significant., Results: Eighty-two (41.4%) of 198 patients underwent irrigation during TT placement. Secondary interventions, thoracic infections, and TT duration were not statistically different in the irrigated cohort. Hospital-free and ICU-free days were higher in the irrigated patients than in the controls. Groups irrigated with ≥1000 mL had significant more hospital-free days (P = 0.007) than those receiving less than 1000 mL., Conclusions: Patients with traumatic HTX who underwent thoracic irrigation at the time of TT placement had decreased hospital and ICU days compared to standard TT placement alone. Specifically, our study demonstrated that patients irrigated with a volume of at least 1000 mL had greater hospital-free days compared to those irrigated with less than 1000 mL., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
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46. Surgical stabilization versus nonoperative treatment for flail and non-flail rib fracture patterns in patients with traumatic brain injury.
- Author
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Prins JTH, Van Lieshout EMM, Ali-Osman F, Bauman ZM, Caragounis EC, Choi J, Christie DB 3rd, Cole PA, DeVoe WB, Doben AR, Eriksson EA, Forrester JD, Fraser DR, Gontarz B, Hardman C, Hyatt DG, Kaye AJ, Ko HJ, Leasia KN, Leon S, Marasco SF, McNickle AG, Nowack T, Ogunleye TD, Priya P, Richman AP, Schlanser V, Semon GR, Su YH, Verhofstad MHJ, Whitis J, Pieracci FM, and Wijffels MME
- Subjects
- Fracture Fixation, Internal, Humans, Length of Stay, Retrospective Studies, Brain Injuries, Traumatic complications, Brain Injuries, Traumatic therapy, Flail Chest surgery, Pneumonia, Rib Fractures complications
- Abstract
Purpose: Literature on outcomes after SSRF, stratified for rib fracture pattern is scarce in patients with moderate to severe traumatic brain injury (TBI; Glasgow Coma Scale ≤ 12). We hypothesized that SSRF is associated with improved outcomes as compared to nonoperative management without hampering neurological recovery in these patients., Methods: A post hoc subgroup analysis of the multicenter, retrospective CWIS-TBI study was performed in patients with TBI and stratified by having sustained a non-flail fracture pattern or flail chest between January 1, 2012 and July 31, 2019. The primary outcome was mechanical ventilation-free days and secondary outcomes were in-hospital outcomes. In multivariable analysis, outcomes were assessed, stratified for rib fracture pattern., Results: In total, 449 patients were analyzed. In patients with a non-flail fracture pattern, 25 of 228 (11.0%) underwent SSRF and in patients with a flail chest, 86 of 221 (38.9%). In multivariable analysis, ventilator-free days were similar in both treatment groups. For patients with a non-flail fracture pattern, the odds of pneumonia were significantly lower after SSRF (odds ratio 0.29; 95% CI 0.11-0.77; p = 0.013). In patients with a flail chest, the ICU LOS was significantly shorter in the SSRF group (beta, - 2.96 days; 95% CI - 5.70 to - 0.23; p = 0.034)., Conclusion: In patients with TBI and a non-flail fracture pattern, SSRF was associated with a reduced pneumonia risk. In patients with TBI and a flail chest, a shorter ICU LOS was observed in the SSRF group. In both groups, SSRF was safe and did not hamper neurological recovery., (© 2022. The Author(s).)
- Published
- 2022
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47. The Las Vegas military-civilian partnership: An origin story and call to action.
- Author
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Kilburn JP, Streit S, Degoes JJ, Andersen A, Gardner M, Fraser DR, and Fildes J
- Subjects
- Humans, Trauma Centers, United States, Military Medicine, Military Personnel, Surgeons, Traumatology
- Abstract
Abstract: Military-civilian partnerships (MCPs) in urban American trauma centers have existed for more than 60 years to assist in the development and maintenance of wartime skills of military medical professionals. In the last 5 years, MCPs have gained congressional support, and their number and variety have grown substantially. The historical impact of these flagship trauma MCPs is well documented, with bidirectional benefit in the advancement of trauma care during the wars in Iraq and Afghanistan both deployed and stateside, and the future aim of MCPs lies primarily in mitigating the "peacetime effect." The majority of data regarding MCPs; however, focus on trauma care and are biased toward surgeons specifically. The Las Vegas (LV) MCP began in 2002 with the similar goal of sustaining Air Force (AF) expeditionary medical skills by embedding AF medics from nearby Nellis Air Force Base (AFB) into University Medical Center of Southern Nevada (UMC), the only Level 1 Trauma Center in Nevada. Over nearly 20 years, the LV-MCP has evolved into an innovative market-based collaboration composed of numerous relationships and programs that are designed to develop and sustain critical skills for military medical personnel in all aspects of expeditionary medicine. This includes AF medical personnel providing care to federal beneficiaries as well as civilian patients in a variety of medical settings. The partnership's central coordinating authority, the Office of Military Medicine-Las Vegas (OMM-LV), brings together military and civilian organizations with distinct and intersecting missions to support the greater LV population and the DoD mission of readiness. The LV-MCP is presented here as a model for the future of MCPs within the integrated local and national trauma and medical systems., (Copyright © 2022 Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a “work of the United States Government” for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government.)
- Published
- 2022
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48. When Is It Safe to Feed After Surgical Feeding Tube Placement? A Survey of EAST Members.
- Author
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Chestovich PJ, McNickle AG, Velez K, Fraser DR, and Kuhls DA
- Subjects
- Enteral Nutrition methods, Humans, Retrospective Studies, Surveys and Questionnaires, Critical Illness therapy, Gastrostomy adverse effects, Gastrostomy methods, Intubation, Gastrointestinal methods
- Abstract
Introduction: Many critically ill trauma and surgical patients require nutritional support. Patients needing long-term enteral access often undergo placement of surgical feeding tubes, including percutaneous endoscopic gastrostomy tube, laparoscopic gastrostomy tube, and open gastrostomy tube. This study was performed to determine national practice patterns for feeding after feeding tube placement., Methods: A 16-question online survey was administered to members of the Eastern Association for the Surgery of Trauma via Qualtrics about feeding practices after placement of the feeding tube. Questions included demographics, training, current practice, annual procedural volume, timing to resume feeds: <2, 6, 12, or 24 h, methods to advance feeds, and reasons behind management decisions. For comparison, responses were grouped into "early" (≤6 h) and "late" (18-24 h) groups. The chi-square test was used, and P < 0.05 was significant., Results: Five hundred sixteen Eastern Association for the Surgery of Trauma members completed the survey. Most (95%) respondents worked at a level 1 or 2 trauma center, and 68% are in academic practice. The most common feeding tube placement was percutaneous endoscopic gastrostomy (median = 25/y, interquartile range = 15-40). Responses showed variability in timing of when feeds were resumed after procedure. Early feeding was not affected by age (≤42 y), trauma center designation, volume, or training programs at the respondent's hospital. Graduates of surgical critical care fellowship were less likely to feed early (P = 0.043)., Conclusions: There is wide variability in feeding practices after surgical feeding tube placement. Given the large quantity of procedures performed, a randomized controlled trial should be performed to determine the optimal timing to resume feeds in critically ill patients., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
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49. Higher risk of auto versus pedestrian crashes in school-age children on school days.
- Author
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Morrison C, Olson T, McNickle AG, Fraser DR, Kuhls DA, Gryder-Culver LK, Slinkard-Barnum S, Saquib SF, Carroll JT, and Chestovich PJ
- Subjects
- Case-Control Studies, Child, Child, Preschool, Humans, Infant, Newborn, Injury Severity Score, Retrospective Studies, Accidents, Traffic prevention & control, Pedestrians
- Abstract
Background: This study examines the rates of pediatric auto versus pedestrian collision (APCs) and determined ages and periods of greatest risk. We hypothesized that the rate of APC in children would be higher on school days and in the timeframes correlating with travel to and from school., Methods: Retrospective case-control study of APC on school and nonschool days for patients younger than 18 years at an urban Level II pediatric trauma center from January 2011 to November 2019. Frequency of APC by hour of the day was plotted overall, for school versus nonschool days and for age groups: 0 year to 4 years, 5 years to 9 years, 10 years to 13 years, and 14 years to 17 years. t Test was used with a p value less than 0.05, which was considered significant., Results: There were 441 pediatric APC in the study period. Frequency of all APC was greater on school days (0.174 vs. 0.101; relative risk [RR], 1.72, p < 0.001), and APC with Injury Severity Score greater than 15 (0.039 vs. 0.024; p = 0.014; RR, 1.67; 95% confidence interval, 1.10-2.56). Comparing school day with nonschool day, the 0-year to 4-year group had no significant difference in APC frequency (0.021 vs. 0.014; p = 0.129), APC frequency was higher on school days in all other age groups: 5 years to 9 years (0.036 vs. 0.019; RR, 1.89; p = 0.0134), 10 years to 13 years (0.055 vs. 0.024; RR, 2.29; p < 0.001), and 14 years to 17 years (0.061 vs. 0.044; RR, 1.39; p = 0.045). The greatest increase in APC on school days was in the 10-year to 13-year age group., Discussion: All school age children are at higher risk of APC on school days. The data support our hypothesis that children are at higher risk of APC during transit to and from school. The age 10-year to 13-year group had a 129% increase in APC frequency on school days. This age group should be a focus of injury prevention efforts., Level of Evidence: Prognostic and Epidemiologic; Level IV., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
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50. AAST multicenter prospective analysis of prehospital tourniquet use for extremity trauma.
- Author
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Schroll R, Smith A, Alabaster K, Schroeppel TJ, Stillman ZE, Teicher EJ, Lita E, Ferrada P, Han J, Fullerton RD, McNickle AG, Fraser DR, Truitt MS, Grossman Verner HM, Todd SR, Turay D, Pop A, Godat LN, Costantini TW, Khor D, Inaba K, Bardes J, Wilson A, Myers JG, Haan JM, Lightwine KL, Berdel HO, Bottiggi AJ, Dorlac W, Zier L, Chang G, Lindner M, Martinez B, Tatum D, Fischer PE, Lieser M, Mabe RC, Lottenberg L, Velopoulos CG, Urban S, Duke M, Brown A, Peckham M, Gongola A, Enniss TM, Teixeira P, Kim DY, Singer G, Ekeh P, Hardman C, Askari R, Okafor B, and Duchesne J
- Subjects
- Adult, Hemorrhage etiology, Hemorrhage therapy, Humans, Prospective Studies, Retrospective Studies, Shock prevention & control, Trauma Centers, Wounds and Injuries complications, Emergency Medical Services, Extremities injuries, Hemorrhage prevention & control, Tourniquets adverse effects
- Abstract
Background: Tourniquet use for extremity hemorrhage control has seen a recent increase in civilian usage. Previous retrospective studies demonstrated that tourniquets improve outcomes for major extremity trauma (MET). No prospective study has been conducted to date. The objective of this study was to evaluate outcomes in MET patients with prehospital tourniquet use. We hypothesized that prehospital tourniquet use in MET decreases the incidence of patients arriving to the trauma center in shock., Methods: Data were collected prospectively for adult patients with MET at 26 Level I and 3 Level II trauma centers from 2015 to 2020. Limbs with tourniquets applied in the prehospital setting were included in the tourniquet group and limbs without prehospital tourniquets were enrolled in the control group., Results: A total of 1,392 injured limbs were enrolled with 1,130 tourniquets, including 962 prehospital tourniquets. The control group consisted of 262 limbs without prehospital tourniquets and 88 with tourniquets placed upon hospital arrival. Prehospital improvised tourniquets were placed in 42 patients. Tourniquets effectively controlled bleeding in 87.7% of limbs. Tourniquet and control groups were similarly matched for demographics, Injury Severity Score, and prehospital vital signs (p > 0.05). Despite higher limb injury severity, patients in the tourniquet group were less likely to arrive in shock compared with the control group (13.0% vs. 17.4%, p = 0.04). The incidence of limb complications was not significantly higher in the tourniquet group (p > 0.05)., Conclusion: This study is the first prospective analysis of prehospital tourniquet use for civilian extremity trauma. Prehospital tourniquet application was associated with decreased incidence of arrival in shock without increasing limb complications. We found widespread tourniquet use, high effectiveness, and a low number of improvised tourniquets. This study provides further evidence that tourniquets are being widely and safely adopted to improve outcomes in civilians with MET., Level of Evidence: Therapeutic/Care Management; Level IV., (Copyright © 2022 American Association for the Surgery of Trauma.)
- Published
- 2022
- Full Text
- View/download PDF
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