1. Isolation and characterization of cytotoxic saponin chloromaloside A from Chlorophytum malayense.
- Author
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Qiu SX, Li XC, Xiong Y, Dong Y, Chai H, Fransworth NR, Pezzuto JM, and Fong HH
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Carbohydrate Conformation, Carbohydrate Sequence, Drug Screening Assays, Antitumor, Humans, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Saponins chemistry, Saponins pharmacology, Tumor Cells, Cultured, Antineoplastic Agents, Phytogenic isolation & purification, Plants chemistry, Saponins isolation & purification, Spirostans
- Abstract
A cytotoxic steroidal glycoside was isolated from Chlorophytum malayense Ridley and its structure was characterized as a known compound, neohecogenin 3-O-beta-D-glucopyranosyl(1-->2)-[beta-D-xylopyranosyl(1-->3)]-beta-D- glucopyranosyl(1-->4)-beta-D-galactopyranoside (chloromaloside A). The structural identification was performed using 2D-NMR and LC/MS/MS analysis. The previous, erroneously assigned 1H-NMR spectral data were revised whereas the published 13C-NMR spectral assignments were confirmed. This compound showed in vitro cytotoxicity against several human cancer cell lines.
- Published
- 2000
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