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2. Differential Activation of Peroxisome Proliferator-Activated Receptor-[Gamma] by Troglitazone and Rosiglitazone

Author

Camp, Heidi S., Li, Ou, Wise, Scott C., Hong, Yu H., Frankowski, Christy L., Shen, Xi-qiang, Vanbogelen, Ruth, and Leff, Todd

Subjects
Avandia (Medication) -- Physiological aspects, Troglitazone -- Physiological aspects, Hypoglycemic agents -- Physiological aspects, Thiazolidinediones -- Physiological aspects, Type 2 diabetes -- Drug therapy, Health, Drug therapy, Physiological aspects
Abstract

The antidiabetic thiazolidinediones, which include troglitazone and rosiglitazone, are ligands for the nuclear receptor peroxisome proliferator-activated receptor (PPAR)-[Gamma] and exert their antihyperglycemic effects by regulation of PPAR-[Gamma]-responsive genes. We report [...]

Published
2000

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