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363 results on '"Frank M. LaFerla"'

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1. The impact of astrocytic NF-κB on healthy and Alzheimer’s disease brains

2. Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis

4. A Trem2 R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

5. Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease

6. A Dual-Function 'TRE-Lox' System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D

7. Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

8. MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis

9. Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse model

10. Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer’s Disease

11. BrightFocus Alzheimer’s Fast Track 2019

12. Author Correction: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

13. Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD

14. Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

15. Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice

16. Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

17. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

18. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition

19. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

20. Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice

21. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

22. Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling

23. Deletion of <scp>MyD88</scp> in astrocytes prevents β‐amyloid‐induced neuropathology in mice

24. New insights into the genetic etiology of Alzheimer's disease and related dementias

25. A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

26. Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches

27. Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse model

28. Astrocytes: From the Physiology to the Disease

29. SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease

30. Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer’s Disease

31. Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease

32. Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tangles

33. Spatial coding defects of hippocampal neural ensemble calcium activities in the 3xTg-AD Alzheimer’s disease mouse model

34. Amyloid-beta impairs TOM1-mediated IL-1R1 signaling

35. Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease

36. MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis

37. Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer’s Disease

38. Author Correction: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

39. Amyloid propagation in a sporadic model of Alzheimer's disease

40. Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer's disease

41. miR‐181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease

42. BrightFocus Alzheimer's Fast Track 2019

43. Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

44. Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models

45. Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology

46. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel

47. Diabetes and Alzheimer’s disease crosstalk

48. Accelerating stem cell trials for Alzheimer's disease

49. P2‐172: THE DYSREGULATION OF TOM1 IN ALZHEIMER'S DISEASE

50. O1‐01‐04: HAβ‐KI: A KNOCK‐IN MOUSE MODEL FOR SPORADIC ALZHEIMER'S DISEASE

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