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2. Immunovirological status in people with perinatal and adult-acquired HIV-1 infection: a multi-cohort analysis from France

Author

Aumaitre, H., Froguel, E., Caby, F., Dellion, S., Gerard, L., Lucht, F., Chirouze, C., Dupon, M., Schmit, Jl, Goujard, C., Allegre, T., Cazenave, B., Hittinger, G., De Truchis, P., Cailhol, J., Duvivier, C., Canestri, A., Bouchaud, O., Karmochkine, M., Salmon-Ceron, D., Zucman, D., Mortier, E., Tubiana, R., Girard, P.M., Pintado, C., Cabie, A., Rabier, V., Morlat, P., Neau, D., Genet, C., Makhloufi, D., Ronot, S Bregigeon, Ghosn, J., Reliquet, V., Perré, P., Pellegrin, Jl, Arvieux, C., Cheneau, C., Bernard, L., Delobel, P., Verdon, R., Jacomet, C., Piroth, L., Ajana, F., Bevilacqua, S., Debab, Y., Lecapitaine, A.L., Cotte, L., Mokhtari, S., Mercie, P., Poubeau, P., Garrait, V., Khuong, Ma, Beck-Wirth, G., Blum, L., Blanche, S., Boccara, F., Prazuck, T., Barbuat, C., Viard, J.P., Stegmann-Planchard, S., Martha, B., Treluyer, J.M., Dore, E., Gaud, C., Niault, M., Fernandes, E., Hitoto, H., Compagnucci, A., Elenga, N., Faye, A., Dollfus, C., Chace, A., Levine, M., Martha, S.A., Floch-Tudal, C., Kebaïli, K., Entz-Werle, N., Tricoire, J., Mazingue, F., Bolot, P., Brazille, P., Goetghebuer, T., Gennotte, A.F., Van Der Linden, D., Schmitz, V., Moutschen, M., Crenn-Hebert, C., Habibi, F., Coursol, A., Guesdon, E., Ceccaldi, P.F., Dehlinger – Paul, M., Pannier, E., Marcou, V., Elleau, C., Achkar, M., Vareil, M.O., Couderc, S., Routier, C., Bouldouyre, M.A., Selleret, L., Chabrol, A., Bellahcene, C., Pluchart, C., Yangui, A., Vignes, D., Alissa, A., Johnson, A., Lachassinne, E., Benbara, A., Karaoui, L., Bongain, A., Yakeu, B., Schmit, J.L., Cravello, L., Hubert, C., Faucher, P., Pinquier, D., Borie, C., Rocchi, D., Brunet-Cartier, C., Briandet, C., Brouard, J., Chalvon-Demersay, A., Rajguru, M., Billiemaz, K., Fresard, A., Moulin, A., Fialaire, P., Mesnard, L., Werner, E., Vintejoux, E., Marian, J., Ranaivojaona, S., Bissuel, F., Abdelhadi, M., Hammou, Y., Genet-Villeger, C., Hatchuel, Y., Bachelard, G., Medus, M., Dendale – Nguyen, J., Guimard, T.S., Martha, A., Rouha, M., Perfezou, P., De Saint Martin, L., Jaffuel, S., Buzele, R., Gousseff, M., Cudeville, C., Vitrat, V., Michau, C., Palenzuela, G., Driessen, M., Heller-Roussin, B., Labaune, J.M., Muanza, B., Massardier, J., Partisani, M., Hau, I., Runel-Belliard, C., Brehin, C., Kebaili, K., Lalande, M., Lagree, M., Lacombe, K., Molina, J.-M., Reynes, J., Robineau, O., Raffi, F., Becker, A., Weiss, L., Allègre, T., Pialoux, G., Souala, F., Rami, A., Katlama, C., Cabié, A., Viard, J.-P., Bastides, F., Michel, C., Salmon, D., Lièvre, J-D Le, Sotto, A., Rouveix, E., Naqvi, A., Brégigeon, S., Rodet, R., Simon-Coutelier, A., Esnault, J.-L., Buzelé, R., Stein, A., Godin-Colet, C., Pichancourt, G., Caraux-Paz, P., Zadeh, M Mohseni, Gérard, L., Lascaux-Cametz, C., Bodard, L., Pellegrin, J.-L., Ettahar, N., Uludag, A., Rosenthal, E., Prevoteau du Clary, F., Jaureguiberry, S., Philibert, P., Lecapitaine, A.-L., Chakvetadze, E., Champagne, H., Daneluzzi, V., Goupil de Bouillé, J., Leprêtre, A., Lamaury, I., Darasteanu, I., Abraham, B., Garipuy, D., Berger, J.-L., Schmit, J.-L., Diallo, K., Gourdon, F., Vaillant, O., Gaborieau, V., Doll, J., Quinsat, D., Geffray, L., Girard, J.-J., Houlbert, D., Perronne, V., Klement, E., Antioniotti, O., Rouzioux, C., Avettand-Fenoel, V., Lortholary, O., Boucly, S., Maignan, A., Thiebaut, R., Meyer, L., Boufassa, F., Charles, M.A., Dray-Spira, R., Legeai, C., Amon, V., Benammar, N., Seng, R., Slama, L., Bonnard, P., Chakvetadze, C., L’Yavanc, T., Capeau, J., Vigouroux, C., Fellahi, S., Bastard, J.P., Oksenhendler, E., Bourge, J.F., Bajzik, V., Sereni, D., Lascoux-Combe, C., Taulera, O., Dien, L.V., Delgado, J., Molina, J.M., Saint-Marc, T., Ferret, S., Pavie, J., Bergmann, J.F., Parrinello, M., BLefebvre, Boudraa, C., Diallo, B., Lupin, C., Herson, S., Simon, A., Edeb, N., Guillevin, L., Tahi, T., Pietri, M.P., Tisne-Dessus, D., Jalbert, C., Yeni, P., Matheron, S., Pahlavan, G., Phung, B., El-Alami Talbi, N., Ramani, Z., Catalano, G., Godard, C., Boue, F., Chambrin, V., Bornarel, D., Schoen, H., Carlier, R., Fantin, B., Poder, C., Dhote, R., Bentata, M., Honore, P., Tuyet, Xuan, Delfraissy, J.F., Chaix, F., Rannou, M.T., Levy, Y., Sobel, A., Dumont, C., Abel, S., Pierre-François, S., Beaujolais, V., Poizot-Martin, I., Zaegel-Faucher, O., Debreux, C., Moreau, J., Van Der Gheynst, E., Thiebaut-Drobacheff, M.C., Foltzer, A., Hoen, B., Faucher, J.F., Gil, H., Ragnaud, J.M., Raymond, I., Louis, I., Hessamfar, M., Baillat, V., De Boever, C Merle, Tramoni, C., Soufflet, A., Guadagnin, P., Choutet, P., Mounoury, O., Brosseau, D., Hue, H., May, T., Wassoumbou, S., Stenzel, M., Bouillon, M.P., Yazdanpanah, Y., Huleux, T., Aissi, E., Pavel, S., Rey, D., Fischer, P., Blaison, G., Martinot, M., Pachart, A., Jeanblanc, F., Touraine, J.L., Trepo, C., Miailhes, P., Kouadjo, K., Thoirain, V., Brochier, C., Perre, P., Leautez, S., Esnault, J.L., Suaud, I., Seng, Rémonie, Frange, Pierre, Faye, Albert, Dollfus, Catherine, le Chenadec, Jérôme, Boufassa, Faroudy, Essat, Asma, Goetghebuer, Tessa, Arezes, Elisa, Avettand-Fènoël, Véronique, Bigna, Jean-Joël, Blanche, Stéphane, Goujard, Cécile, Meyer, Laurence, Warszawski, Josiane, and Viard, Jean-Paul

Published
2024
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3. Performance of clinical metagenomics in France: a prospective observational study

Author

Fourgeaud, Jacques, Regnault, Béatrice, Ok, Vichita, Da Rocha, Nicolas, Sitterlé, Émilie, Mekouar, Meryem, Faury, Hélène, Milliancourt-Seels, Catherine, Jagorel, Florence, Chrétien, Delphine, Bigot, Thomas, Troadec, Éric, Marques, Isabelle, Serris, Alexandra, Seilhean, Danielle, Neven, Bénédicte, Frange, Pierre, Ferroni, Agnès, Lecuit, Marc, Nassif, Xavier, Lortholary, Olivier, Leruez-Ville, Marianne, Pérot, Philippe, Eloit, Marc, and Jamet, Anne

Published
2024
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4. Novel scores relevant to antimicrobial resistance and hospital-acquired infections developed with data from a multi-hospital consortium in the Parisian region of France

Author

Lefevre, Laurence Armand, Aubry, Alexandra, Avettand-Fenoel, Véronique, Barbut, Frédéric, Belec, Laurent, Bercot, Béatrice, Bonacorsi, Stéphane, Calvez, Vincent, Cambau, Emmanuelle, Carbonnelle, Etienne, Charpentier, Charlotte, Chevaliez, Stéphane, Decousser, Jean-Winoc, Delaugerre, Constance, Descamps, Diane, Dortet, Laurent, Doucet-Populaire, Florence, Frange, Pierre, Fourati, Slim, Gaillard, Jean-Louis, Gault, Elyanne, Herrmann, Jean-Louis, Jarlier, Vincent, Kerneis, Solen, Le Goff, Jérôme, Mainardi, Jean-Luc, Marcelin, Anne-Geneviève, Morand-Joubert, Laurence, Pawlotsky, Jean-Michel, Poyart, Claire, Rameix-Welti, Marie-Anne, Robert, Jérôme, Rodriguez, Christophe, Roque Afonso, Anne-Marie, Rottman, Martin, Rozenberg, Flore, Ruppé, Etienne, Skurnik, David, Veziris, Nicolas, Zahar, Jean-Ralph, Barnaud, Guilene, Billard-Pomares, Typhaine, Cuzon, Gaëlle, Decré, Dominique, Doloy, Alexandra, Donay, Jean-Luc, Drieux-Rouzet, Laurence, Durand, Isabelle, Ferroni, Agnès, Fihman, Vincent, Fortineau, Nicolas, Gomart, Camille, Grall, Nathalie, Guillet-Caruba, Christelle, Jaureguy, Françoise, Lalande, Valérie, Landraud, Luce, Leflon, Véronique, Mariani, Patricia, Mihaila, Liliana, Moissenet, Didier, Noussair, Latifa, Podglajen, Isabelle, Poilane, Isabelle, Poupet, Hélène, Rondinaud, Emilie, Tardy, Valérie Sivadon, Trystram, David, Verdet, Charlotte, Vigier, Emmanuelle, Vimont-Billarant, Sophie, Amarsy, R., Granger, B., Fournier, S., Monteil, C., Trystram, D., Siorat, V., Jarlier, V., and Robert, J.

Published
2024
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5. Activated phosphoinositide 3-kinase δ syndrome: Update from the ESID Registry and comparison with other autoimmune-lymphoproliferative inborn errors of immunity

Author

Seidel, Markus G., Seppänen, Mikko R.J., Gennery, Andrew, Kanariou, Maria G., Tantou, Sofia, Grigoriadou, Sofia, Cericola, Gabriella, Hanitsch, Leif G., Scheibenbogen, Carmen, Hlaváčková, Eva O., Krivan, Gergely, McGuire, Frances K., Leahy, Timothy Ronan, Edgar, John David M., Bakhtiar, Shahrzad, Bader, Peter, Rohner, Geraldine Blanchard, Haerynck, Filomeen, Claes, Karlien, Lehmberg, Kai, Müller, Ingo, Farmand, Susan, Fasshauer, Maria, Graf, Dagmar, Neves, Joao Farela, Kostyuchenko, Larysa, Gonzalez-Granado, Luis Ignacio, Jeseňák, Miloš, Carrabba, Maria, Fabio, Giovanna, Pignata, Claudio, Giardino, Giuliana, Karadağ, Ilknur Kökçü, Yıldıran, Alişan, Hancioglu, Gonca, Králíčková, Pavlína, Steinmann, Sandra, Pietrucha, Barbara Maria, Gernert, Michael, Soomann, Maarja, Witte, Torsten, Markocsy, Adam, Wolska-Kusnierz, Beata, Randrianomenjanahary, Philippe, Rouger, Jérémie, Kostaridou, Stavroula, Zabara, Dariia V., Rodina, Yulia A., Shvets, Oksana A., Maccari, Maria Elena, Wolkewitz, Martin, Schwab, Charlotte, Lorenzini, Tiziana, Leiding, Jennifer W., Aladjdi, Nathalie, Abolhassani, Hassan, Abou-Chahla, Wadih, Aiuti, Alessandro, Azarnoush, Saba, Baris, Safa, Barlogis, Vincent, Barzaghi, Federica, Baumann, Ulrich, Bloomfield, Marketa, Bohynikova, Nadezda, Bodet, Damien, Boutboul, David, Bucciol, Giorgia, Buckland, Matthew S., Burns, Siobhan O., Cancrini, Caterina, Cathébras, Pascal, Cavazzana, Marina, Cheminant, Morgane, Chinello, Matteo, Ciznar, Peter, Coulter, Tanya I., D’Aveni, Maud, Ekwall, Olov, Eric, Zelimir, Eren, Efrem, Fasth, Anders, Frange, Pierre, Fournier, Benjamin, Garcia-Prat, Marina, Gardembas, Martine, Geier, Christoph, Ghosh, Sujal, Goda, Vera, Hammarström, Lennart, Hauck, Fabian, Heeg, Maximilian, Heropolitanska-Pliszka, Edyta, Hilfanova, Anna, Jolles, Stephen, Karakoc-Aydiner, Elif, Kindle, Gerhard R., Kiykim, Ayca, Klemann, Christian, Koletsi, Patra, Koltan, Sylwia, Kondratenko, Irina, Körholz, Julia, Krüger, Renate, Jeziorski, Eric, Levy, Romain, Le Guenno, Guillaume, Lefevre, Guillaume, Lougaris, Vassilios, Marzollo, Antonio, Mahlaoui, Nizar, Malphettes, Marion, Meinhardt, Andrea, Merlin, Etienne, Meyts, Isabelle, Milota, Tomas, Moreira, Fernando, Moshous, Despina, Mukhina, Anna, Neth, Olaf, Neubert, Jennifer, Neven, Benedicte, Nieters, Alexandra, Nove-Josserand, Raphaele, Oksenhendler, Eric, Ozen, Ahmet, Olbrich, Peter, Perlat, Antoinette, Pac, Malgorzata, Schmid, Jana Pachlopnik, Pacillo, Lucia, Parra-Martinez, Alba, Paschenko, Olga, Pellier, Isabelle, Sefer, Asena Pinar, Plebani, Alessandro, Plantaz, Dominique, Prader, Seraina, Raffray, Loic, Ritterbusch, Henrike, Riviere, Jacques G., Rivalta, Beatrice, Rusch, Stephan, Sakovich, Inga, Savic, Sinisa, Scheible, Raphael, Schleinitz, Nicolas, Schuetz, Catharina, Schulz, Ansgar, Sediva, Anna, Semeraro, Michaela, Sharapova, Svetlana O., Shcherbina, Anna, Slatter, Mary A., Sogkas, Georgios, Soler-Palacin, Pere, Speckmann, Carsten, Stephan, Jean-Louis, Suarez, Felipe, Tommasini, Alberto, Trück, Johannes, Uhlmann, Annette, van Aerde, Koen J., van Montfrans, Joris, von Bernuth, Horst, Warnatz, Klaus, Williams, Tony, Worth, Austen J.J., Ip, Winnie, Picard, Capucine, Catherinot, Emilie, Nademi, Zohreh, Grimbacher, Bodo, Forbes Satter, Lisa R., Kracker, Sven, Chandra, Anita, Condliffe, Alison M., and Ehl, Stephan

Published
2023
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8. Spatiotemporal dynamics of HIV-1 transmission in France (1999–2014) and impact of targeted prevention strategies

Author

Chaillon, Antoine, Essat, Asma, Frange, Pierre, Smith, Davey M, Delaugerre, Constance, Barin, Francis, Ghosn, Jade, Pialoux, Gilles, Robineau, Olivier, Rouzioux, Christine, Goujard, Cécile, Meyer, Laurence, Chaix, Marie-Laure, and on behalf the ANRS PRIMO Cohort Study

Subjects
Microbiology, Biological Sciences, Clinical Research, Genetics, Infectious Diseases, Sexually Transmitted Infections, Sexual and Gender Minorities (SGM/LGBT*), HIV/AIDS, Prevention, 2.2 Factors relating to the physical environment, Infection, Adolescent, Adult, Aged, Cluster Analysis, Female, France, Genotype, HIV Infections, HIV-1, Humans, Male, Middle Aged, Molecular Epidemiology, Sequence Analysis, DNA, Spatio-Temporal Analysis, Young Adult, pol Gene Products, Human Immunodeficiency Virus, Transmission network, Phylogeography, Primary infection, Treatment as prevention, on behalf the ANRS PRIMO Cohort Study, Clinical Sciences, Virology
Abstract

BackgroundCharacterizing HIV-1 transmission networks can be important in understanding the evolutionary patterns and geospatial spread of the epidemic. We reconstructed the broad molecular epidemiology of HIV from individuals with primary HIV-1 infection (PHI) enrolled in France in the ANRS PRIMO C06 cohort over 15 years.ResultsSociodemographic, geographic, clinical, biological and pol sequence data from 1356 patients were collected between 1999 and 2014. Network analysis was performed to infer genetic relationships, i.e. clusters of transmission, between HIV-1 sequences. Bayesian coalescent-based methods were used to examine the temporal and spatial dynamics of identified clusters from different regions in France. We also evaluated the use of network information to target prevention efforts. Participants were mostly Caucasian (85.9%) and men (86.7%) who reported sex with men (MSM, 71.4%). Overall, 387 individuals (28.5%) were involved in clusters: 156 patients (11.5%) in 78 dyads and 231 participants (17%) in 42 larger clusters (median size: 4, range 3-41). Compared to individuals with single PHI (n = 969), those in clusters were more frequently men (95.9 vs 83%, p

Published
2017

11. Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF)

Author

Schnell, David, Azoulay, Elie, Benoit, Dominique, Clouzeau, Benjamin, Demaret, Pierre, Ducassou, Stéphane, Frange, Pierre, Lafaurie, Matthieu, Legrand, Matthieu, Meert, Anne-Pascale, Mokart, Djamel, Naudin, Jérôme, Pene, Frédéric, Rabbat, Antoine, Raffoux, Emmanuel, Ribaud, Patricia, Richard, Jean-Christophe, Vincent, François, Zahar, Jean-Ralph, and Darmon, Michael

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Hematology, Rare Diseases, Good Health and Well Being, Antibiotics, Guidelines, Intensive care units, Isolation, Neutropenia, Prognosis, Public Health and Health Services, Clinical sciences
Abstract

Neutropenia is defined by either an absolute or functional defect (acute myeloid leukemia or myelodysplastic syndrome) of polymorphonuclear neutrophils and is associated with high risk of specific complications that may require intensive care unit (ICU) admission. Specificities in the management of critically ill neutropenic patients prompted the establishment of guidelines dedicated to intensivists. These recommendations were drawn up by a panel of experts brought together by the French Intensive Care Society in collaboration with the French Group for Pediatric Intensive Care Emergencies, the French Society of Anesthesia and Intensive Care, the French Society of Hematology, the French Society for Hospital Hygiene, and the French Infectious Diseases Society. Literature review and formulation of recommendations were performed using the Grading of Recommendations Assessment, Development and Evaluation system. Each recommendation was then evaluated and rated by each expert using a methodology derived from the RAND/UCLA Appropriateness Method. Six fields are covered by the provided recommendations: (1) ICU admission and prognosis, (2) protective isolation and prophylaxis, (3) management of acute respiratory failure, (4) organ failure and organ support, (5) antibiotic management and source control, and (6) hematological management. Most of the provided recommendations are obtained from low levels of evidence, however, suggesting a need for additional studies. Seven recommendations were, however, associated with high level of evidences and are related to protective isolation, diagnostic workup of acute respiratory failure, medical management, and timing surgery in patients with typhlitis.

Published
2016

13. Letermovir for CMV Prophylaxis in Very High-Risk Pediatric Hematopoietic Stem Cell Transplantation Recipients for Inborn Errors of Immunity

Author

César, Thibaut, primary, Le, Minh P., additional, Klifa, Roman, additional, Castelle, Martin, additional, Fournier, Benjamin, additional, Lévy, Romain, additional, Chbihi, Marwa, additional, Courteille, Virginie, additional, Moshous, Despina, additional, Blanche, Stéphane, additional, Alligon, Mickaël, additional, Leruez-Ville, Marianne, additional, Peytavin, Gilles, additional, Frange, Pierre, additional, and Neven, Bénédicte, additional

Published
2023
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14. Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units

Author

Decalonne, Marie, Dos Santos, Sandra, Gimenes, Rémi, Goube, Florent, Abadie, Géraldine, Aberrane, Saïd, Ambrogi, Vanina, Baron, Raoul, Barthelemy, Patrick, Bauvin, Isabelle, Belmonte, Olivier, Benabid, Emilie, Ammar, Rafik Ben, Yahia, Salma Ben Hadj, Berrouane, Yasmina, Berthelot, Philippe, Beuchee, Alain, Bille, Emmanuelle, Bolot, Pascal, Bordes-Couecou, Stéphanie, Bouissou, Antoine, Bourdon, Sandra, Bourgeois-Nicolaos, Nadège, Boyer, Sophie, Cattoen, Christian, Cattoir, Vincent, Chaplain, Chantal, Chatelet, Céline, Claudinon, Aurore, Chautemps, Nathalie, Cormier, Hélène, Coroller-Bec, Céline, Cotte, Benjamin, De Chillaz, Carole, Dauwalder, Olivier, Davy, Aude, Delorme, Martine, Demasure, Maryvonne, Desfrere, Luc, Drancourt, Michel, Dupin, Clarisse, Faraut-Derouin, Véronique, Florentin, Arnaud, Forget, Virginie, Fortineau, Nicolas, Foucan, Tania, Frange, Pierre, Gambarotto, Karine, Gascoin, Géraldine, Gibert, Laure, Gilquin, Jacques, Glanard, Audrey, Grando, Jacqueline, Gravet, Alain, Guinard, Jérôme, Hery-Arnaud, Geneviève, Huart, Claire, Idri, Nadia, Jellimann, Jean-Marc, Join-Lambert, Olivier, Joron, Sylvie, Jouvencel, Philippe, Kempf, Marie, Ketterer-Martinon, Sophie, Khecharem, Mouna, Klosowski, Serge, Labbe, Franck, Lacazette, Adeline, Lapeyre, Fabrice, Larche, Jérôme, Larroude, Peggy, Le Pourhiennec, Anne, Le Sache, Nolwenn, Ledru, Sylvie, Lefebvre, Annick, Legeay, Clément, Lemann, Florence, Lesteven, Claire, Levast-Raffin, Marion, Leyssene, David, Ligi, Isabelle, Lozniewski, Alain, Lureau, Pierre, Mallaval, Franck-Olivier, Malpote, Edith, Marret, Stéphane, Martres, Pascale, Menard, Guillaume, Menvielle, Laura, Mereghetti, Laurent, Merle, Véronique, Minery, Pascale, Morange, Virginie, Mourdie, Julien, Muggeo, Anaelle, Nakhleh, Jean, Noulard, Marie-Noëlle, Olive, Claude, Patural, Hugues, Penn, Pascale, Petitfrere, Manuel, Pozetto, Bruno, Riviere, Brigitte, Robine, Audrey, Ceschin, Christine Roques, Ruimy, Raymond, Siali, Amine, Soive, Stéphanie, Slimani, Souad, Trentesaux, Anne-Sophie, Trivier, Dominique, Vandenbussche, Christian, Villeneuve, Laurent, Werner, Evelyne, Le Vu, Stéphane, and Van Der Mee-Marquet, Nathalie

Published
2020
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15. HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007–12: impact on susceptibility to first-line strategies

Author

Frange, Pierre, Assoumou, Lambert, Descamps, Diane, Chéret, Antoine, Goujard, Cécile, Tran, Laurent, Gousset, Marine, Avettand-Fenoël, Veronique, Bocket, Laurence, Fafi-Kremer, Samira, Guinard, Jerome, Morand-Joubert, Laurence, Nicot, Florence, Plantier, Jean-Christophe, Rogez, Sylvie, Wirden, Marc, Rouzioux, Christine, Meyer, Laurence, Chaix, Marie-Laure, Abel, S, Abraham, B, Allegre, T, Antoniotti, A, Armero, R, Audhuy, B, Aumaitre, H, Beaucaire, G, Beck-Wirth, G, Berger, JL, Bernard, L, Beuscart, C, Bodard, L, Bouchaud, O, Boué, F, Cabane, J-P, Cabie, A, Champagne, H, Cheneau, C, Chennebault, J-M, Cheret, A, Christian, B, Compagnucci, A, Daneluzzi, V, Debab, Y, Dellamonica, P, Delfraissy, J-F, Devidas, A, Diab, G, Doll, J, Drobacheff-Thebaut, MC, Durel, A, Duvivier, C, Esnault, J-L, Faba, L, Froguel, E, Garipuy, D, Garrait, V, Geffray, L, Genet, C, Genet, P, Gerard, L, Ghosn, J, Girard, J-J, Girard, P-M, Godin-Collet, C, Hochedez, P, Hoen, B, Houlbert, D, Jacomet, C, Jeantils, V, Jidar, K, Katlama, C, Klement, E, Lafeuillade, A, Lascoux, C, Launay, V, Lepretre, A, Levy, Y, Makhloufi, D, Malbec, D, Martha, B, May, T, Merrien, D, Miailhes, P, Miodovski, C, Molina, J-M, Morlat, P, Mortier, E, Neau, D, Obadia, M, Patey, O, Pellegrin, J-L, Perronne, V, Philibert, P, Pialoux, G, Pichancourt, G, Piroth, L, Poinsignon, Y, Poizot-Martin, I, and Prazuck, T

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, HIV/AIDS, Antimicrobial Resistance, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Anti-HIV Agents, Disease Transmission, Infectious, Drug Resistance, Viral, Female, France, Genotype, Genotyping Techniques, HIV Infections, HIV-1, Homosexuality, Male, Humans, Male, Mutation, Missense, Prevalence, resistance-associated mutations, primary HIV infection, French ANRS CO 6 PRIMO Cohort, the ANRS 147 OPTIPRIM Clinical Trial and the AC11 Resistance Study Groups, French ANRS CO 6 PRIMO Cohort the ANRS 147 OPTIPRIM Clinical Trial and the AC11 Resistance Study Groups, Microbiology, Pharmacology and Pharmaceutical Sciences, Clinical sciences, Pharmacology and pharmaceutical sciences
Abstract

BackgroundOur study describes the prevalence of transmitted drug resistance (TDR) among 1318 French patients diagnosed at the time of primary HIV-1 infection (PHI) in 2007-12.MethodsHIV-1 resistance-associated mutations (RAMs) were characterized using both the 2009 WHO list of mutations and the French ANRS algorithm. A genotypic susceptibility score was estimated for each first-line recommended ART combination.ResultsPatients were mainly MSM (72.6%). Non-B variants were identified in 33.7% of patients. The proportion of TDR was estimated as 11.7% (95% CI 10.0-13.5). The prevalences of PI-, NRTI-, first-generation NNRTI and etravirine/rilpivirine-associated RAMs were 2.5%, 5.2%, 3.9% and 3.2%, respectively. Single, dual and triple class resistance was found in 9.6%, 1.0% and 1.1% of cases, respectively. Additionally, 5/331 strains isolated in 2010-12 had integrase inhibitor (II)-related RAMs (isolated E157Q mutation in all cases). TDR was more common among MSM than in other groups (12.9% versus 8.6%, P = 0.034), and in case of B versus non-B subtype infections (13.6% versus 7.9%, P = 0.002). The proportions of fully active combinations were ≥99.2%, ≥97.3% and ≥95.3% in cases of PI-, II- and NNRTI-based regimens, respectively. In 2010-12, the proportion of fully active efavirenz-based ART was lower in cases of subtype B versus non-B infection (P = 0.021).ConclusionsCompared with our previous studies, the proportion of NRTI- and first-generation NNRTI-related TDR has continued to decline in French seroconverters. However, subtype B-infected MSM could drive the spread of resistant HIV strains. Finally, we suggest preferring PI- or II- to NNRTI-based combinations to treat PHI patients.

Published
2015

16. 8th IAS Conference on HIV Pathogenesis, Treatment & Prevention 19–22 July 2015, Vancouver, Canada

Author

Pate, Kelly Metcalf, Pohlmeyer, Chris, Walker‐Sperling, Victoria, Foote, Jeremy, Najarro, Kevin, Cryer, Catherine, Salgado, Maria, Gama, Lucio, Engle, Elizabeth, Shirk, Erin, Queen, Suzanne, Chioma, Stanley, Vermillion, Meghan, Bullock, Brandon, Li, Ming, Lyons, Claire, Adams, Robert, Zink, Chris, Clements, Janice, Mankowski, Joseph, Blankson, Joel, Micci, Luca, Ryan, Emily, Fromentin, Rémi, Benne, Clarisse, Chomont, Nicolas, Lifson, Jeffrey, Paiardini, Mirko, Lee, Sulggi, Fromentin, Remi, Silicano, Robert, Silicano, Janet, Richman, Douglas, O'Doherty, Una, Palmer, Sarah, Burbelo, Peter, Deeks, Steven, Ghneim, Khader, Ahlers, Jeff, Fourati, Slim, Shive, Carey, Cameron, Mark, Mukerjee, Pranab, Ghannoum, Mahmoud, Rodriguez, Benigno, Lederman, Michael, Sekaly, Rafick, Frange, Pierre, Faye, Albert, Avettand‐Fenoel, Veronique, Bellaton, Erainna, Deschamps, Diane, Angin, Mathieu, Caillat‐Zucman, Sophie, Peytavin, Gilles, Le Chenadec, Jerome, Warszawski, Josiane, Rouzioux, Christine, Saez‐Cirion, Asier, Cohort, ANRS Epf‐Co10 Pediatric, Chang, Christina, Cameron, Paul, Elliott, Julian, Perelson, Alan, Roche, Michael, Dantanarayana, Ashanti, Solomon, Ajantha, Naranbhai, Vivek, Tenakoon, Surekha, Hoh, Rebecca, McMahon, James, Sikaris, Ken, Hartogensis, Wendy, Bacchetti, Peter, Hecht, Frederick, Deeks, Steve, Lewin, Sharon, Byrareddy, Siddappa, Arthos, James, Cicala, Claudia, Reimann, Keith, Parslow, Tristram, Santangelo, Philip, Villinger, Francois, Fauci, Anthony, Ansari, Aftab, George, Michael, Weiser, Barbara, Burger, Harold, Lewy, Tyler, Anastos, Kathryn, Asmuth, David, Somsouk, Ma, Hunt, Peter, Min, Zhong, Miller, Christopher, and Li, Xiao Dong

Subjects
Mental Health, Digestive Diseases, Infectious Diseases, Pediatric AIDS, Bioengineering, Prevention, Clinical Research, Genetics, Health Services, Pediatric, Behavioral and Social Science, HIV/AIDS, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Reproductive health and childbirth, Good Health and Well Being, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Published
2015

17. Correction: Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis

Author

Rhee, Soo-Yon, Blanco, Jose Luis, Jordan, Michael R, Taylor, Jonathan, Lemey, Philippe, Varghese, Vici, Hamers, Raph L, Bertagnolio, Silvia, de Wit, Tobias F Rinke, Aghokeng, Avelin F, Albert, Jan, Avi, Radko, Avila-Rios, Santiago, Bessong, Pascal O, Brooks, James I, Boucher, Charles AB, Brumme, Zabrina L, Busch, Michael P, Bussmann, Hermann, Chaix, Marie-Laure, Chin, Bum Sik, D'Aquin, Toni T, De Gascun, Cillian F, Derache, Anne, Descamps, Diane, Deshpande, Alaka K, Djoko, Cyrille F, Eshleman, Susan H, Fleury, Herve, Frange, Pierre, Fujisaki, Seiichiro, Harrigan, P Richard, Hattori, Junko, Holguin, Africa, Hunt, Gillian M, Ichimura, Hiroshi, Kaleebu, Pontiano, Katzenstein, David, Kiertiburanakul, Sasisopin, Kim, Jerome H, Kim, Sung Soon, Li, Yanpeng, Lutsar, Irja, Morris, Lynn, Ndembi, Nicaise, Kee, Peng NG, Paranjape, Ramesh S, Peeters, Martine, Poljak, Mario, Price, Matt A, Ragonnet-Cronin, Manon L, Reyes-Terán, Gustavo, Rolland, Morgane, Sirivichayakul, Sunee, Smith, Davey M, Soares, Marcelo A, Soriano, Vincent V, Ssemwanga, Deogratius, Stanojevic, Maja, Stefani, Mariane A, Sugiura, Wataru, Sungkanuparph, Somnuek, Tanuri, Amilcar, Tee, Kok Keng, Truong, Hong-Ha M, van de Vijver, David AMC, Vidal, Nicole, Yang, Chunfu, Yang, Rongge, Yebra, Gonzalo, Ioannidis, John PA, Vandamme, Anne-Mieke, and Shafer, Robert W

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Good Health and Well Being, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Published
2015

18. 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015).

Author

Pate, Kelly Metcalf, Pohlmeyer, Chris, Walker-Sperling, Victoria, Foote, Jeremy, Najarro, Kevin, Cryer, Catherine, Salgado, Maria, Gama, Lucio, Engle, Elizabeth, Shirk, Erin, Queen, Suzanne, Chioma, Stanley, Vermillion, Meghan, Bullock, Brandon, Li, Ming, Lyons, Claire, Adams, Robert, Zink, Chris, Clements, Janice, Mankowski, Joseph, Blankson, Joel, Micci, Luca, Ryan, Emily, Fromentin, Rémi, Benne, Clarisse, Chomont, Nicolas, Lifson, Jeffrey, Paiardini, Mirko, Lee, Sulggi, Fromentin, Remi, Silicano, Robert, Silicano, Janet, Richman, Douglas, O'Doherty, Una, Palmer, Sarah, Burbelo, Peter, Deeks, Steven, Ghneim, Khader, Ahlers, Jeff, Fourati, Slim, Shive, Carey, Cameron, Mark, Mukerjee, Pranab, Ghannoum, Mahmoud, Rodriguez, Benigno, Lederman, Michael, Sekaly, Rafick, Frange, Pierre, Faye, Albert, Avettand-Fenoel, Veronique, Bellaton, Erainna, Deschamps, Diane, Angin, Mathieu, Caillat-Zucman, Sophie, Peytavin, Gilles, Le Chenadec, Jerome, Warszawski, Josiane, Rouzioux, Christine, Saez-Cirion, Asier, Chang, Christina, Cameron, Paul, Elliott, Julian, Perelson, Alan, Roche, Michael, Dantanarayana, Ashanti, Solomon, Ajantha, Naranbhai, Vivek, Tenakoon, Surekha, Hoh, Rebecca, McMahon, James, Sikaris, Ken, Hartogensis, Wendy, Bacchetti, Peter, Hecht, Frederick, Deeks, Steve, Lewin, Sharon, Byrareddy, Siddappa, Arthos, James, Cicala, Claudia, Reimann, Keith, Parslow, Tristram, Santangelo, Philip, Villinger, Francois, Fauci, Anthony, Ansari, Aftab, George, Michael, Weiser, Barbara, Burger, Harold, Lewy, Tyler, Anastos, Kathryn, Asmuth, David, Somsouk, Ma, Hunt, Peter, Min, Zhong, Miller, Christopher, Li, Xiao Dong, and Hinkle, John

Subjects
Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Published
2015

20. Prevalence and risk factors of toxigenic Clostridioides difficile asymptomatic carriage in 11 French hospitals

Author

Jolivet, Sarah, primary, Couturier, Jeanne, additional, Grohs, Patrick, additional, Vilfaillot, Aurélie, additional, Zahar, Jean-Ralph, additional, Frange, Pierre, additional, Casetta, Anne, additional, Moulin, Véronique, additional, Lawrence, Christine, additional, Baune, Patricia, additional, Bourgeois, Cléo, additional, Bouffier, Axel, additional, Laussucq, Claudine, additional, Sienzonit, Lydia, additional, Picard, Simon, additional, Podglajen, Isabelle, additional, Kassis-Chikhani, Najiby, additional, and Barbut, Frédéric, additional

Published
2023
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21. Ribosomal Protein SA Haploinsufficiency in Humans with Isolated Congenital Asplenia

Author

Bolze, Alexandre, Mahlaoui, Nizar, Byun, Minji, Turner, Bridget, Trede, Nikolaus, Ellis, Steven R, Abhyankar, Avinash, Itan, Yuval, Patin, Etienne, Brebner, Samuel, Sackstein, Paul, Puel, Anne, Picard, Capucine, Abel, Laurent, Quintana-Murci, Lluis, Faust, Saul N, Williams, Anthony P, Baretto, Richard, Duddridge, Michael, Kini, Usha, Pollard, Andrew J, Gaud, Catherine, Frange, Pierre, Orbach, Daniel, Emile, Jean-Francois, Stephan, Jean-Louis, Sorensen, Ricardo, Plebani, Alessandro, Hammarstrom, Lennart, Conley, Mary Ellen, Selleri, Licia, and Casanova, Jean-Laurent

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Clinical Research, Congenital Structural Anomalies, Pediatric, DNA Mutational Analysis, Genetic Loci, Haploinsufficiency, Heterotaxy Syndrome, Humans, Mutation, Pedigree, Penetrance, Receptors, Laminin, Ribosomal Proteins, Spleen, General Science & Technology
Abstract

Isolated congenital asplenia (ICA) is characterized by the absence of a spleen at birth in individuals with no other developmental defects. The patients are prone to life-threatening bacterial infections. The unbiased analysis of exomes revealed heterozygous mutations in RPSA in 18 patients from eight kindreds, corresponding to more than half the patients and over one-third of the kindreds studied. The clinical penetrance in these kindreds is complete. Expression studies indicated that the mutations carried by the patients-a nonsense mutation, a frameshift duplication, and five different missense mutations-cause autosomal dominant ICA by haploinsufficiency. RPSA encodes ribosomal protein SA, a component of the small subunit of the ribosome. This discovery establishes an essential role for RPSA in human spleen development.

Published
2013

23. Activated phosphoinositide 3-kinase δ syndrome: Update from the ESID Registry and comparison with other autoimmune-lymphoproliferative inborn errors of immunity

Author

Maccari, Maria Elena, primary, Wolkewitz, Martin, additional, Schwab, Charlotte, additional, Lorenzini, Tiziana, additional, Leiding, Jennifer W., additional, Aladjdi, Nathalie, additional, Abolhassani, Hassan, additional, Abou-Chahla, Wadih, additional, Aiuti, Alessandro, additional, Azarnoush, Saba, additional, Baris, Safa, additional, Barlogis, Vincent, additional, Barzaghi, Federica, additional, Baumann, Ulrich, additional, Bloomfield, Marketa, additional, Bohynikova, Nadezda, additional, Bodet, Damien, additional, Boutboul, David, additional, Bucciol, Giorgia, additional, Buckland, Matthew S., additional, Burns, Siobhan O., additional, Cancrini, Caterina, additional, Cathébras, Pascal, additional, Cavazzana, Marina, additional, Cheminant, Morgane, additional, Chinello, Matteo, additional, Ciznar, Peter, additional, Coulter, Tanya I., additional, D’Aveni, Maud, additional, Ekwall, Olov, additional, Eric, Zelimir, additional, Eren, Efrem, additional, Fasth, Anders, additional, Frange, Pierre, additional, Fournier, Benjamin, additional, Garcia-Prat, Marina, additional, Gardembas, Martine, additional, Geier, Christoph, additional, Ghosh, Sujal, additional, Goda, Vera, additional, Hammarström, Lennart, additional, Hauck, Fabian, additional, Heeg, Maximilian, additional, Heropolitanska-Pliszka, Edyta, additional, Hilfanova, Anna, additional, Jolles, Stephen, additional, Karakoc-Aydiner, Elif, additional, Kindle, Gerhard R., additional, Kiykim, Ayca, additional, Klemann, Christian, additional, Koletsi, Patra, additional, Koltan, Sylwia, additional, Kondratenko, Irina, additional, Körholz, Julia, additional, Krüger, Renate, additional, Jeziorski, Eric, additional, Levy, Romain, additional, Le Guenno, Guillaume, additional, Lefevre, Guillaume, additional, Lougaris, Vassilios, additional, Marzollo, Antonio, additional, Mahlaoui, Nizar, additional, Malphettes, Marion, additional, Meinhardt, Andrea, additional, Merlin, Etienne, additional, Meyts, Isabelle, additional, Milota, Tomas, additional, Moreira, Fernando, additional, Moshous, Despina, additional, Mukhina, Anna, additional, Neth, Olaf, additional, Neubert, Jennifer, additional, Neven, Benedicte, additional, Nieters, Alexandra, additional, Nove-Josserand, Raphaele, additional, Oksenhendler, Eric, additional, Ozen, Ahmet, additional, Olbrich, Peter, additional, Perlat, Antoinette, additional, Pac, Malgorzata, additional, Schmid, Jana Pachlopnik, additional, Pacillo, Lucia, additional, Parra-Martinez, Alba, additional, Paschenko, Olga, additional, Pellier, Isabelle, additional, Sefer, Asena Pinar, additional, Plebani, Alessandro, additional, Plantaz, Dominique, additional, Prader, Seraina, additional, Raffray, Loic, additional, Ritterbusch, Henrike, additional, Riviere, Jacques G., additional, Rivalta, Beatrice, additional, Rusch, Stephan, additional, Sakovich, Inga, additional, Savic, Sinisa, additional, Scheible, Raphael, additional, Schleinitz, Nicolas, additional, Schuetz, Catharina, additional, Schulz, Ansgar, additional, Sediva, Anna, additional, Semeraro, Michaela, additional, Sharapova, Svetlana O., additional, Shcherbina, Anna, additional, Slatter, Mary A., additional, Sogkas, Georgios, additional, Soler-Palacin, Pere, additional, Speckmann, Carsten, additional, Stephan, Jean-Louis, additional, Suarez, Felipe, additional, Tommasini, Alberto, additional, Trück, Johannes, additional, Uhlmann, Annette, additional, van Aerde, Koen J., additional, van Montfrans, Joris, additional, von Bernuth, Horst, additional, Warnatz, Klaus, additional, Williams, Tony, additional, Worth, Austen J.J., additional, Ip, Winnie, additional, Picard, Capucine, additional, Catherinot, Emilie, additional, Nademi, Zohreh, additional, Grimbacher, Bodo, additional, Forbes Satter, Lisa R., additional, Kracker, Sven, additional, Chandra, Anita, additional, Condliffe, Alison M., additional, Ehl, Stephan, additional, Seidel, Markus G., additional, Seppänen, Mikko R.J., additional, Gennery, Andrew, additional, Kanariou, Maria G., additional, Tantou, Sofia, additional, Grigoriadou, Sofia, additional, Cericola, Gabriella, additional, Hanitsch, Leif G., additional, Scheibenbogen, Carmen, additional, Hlaváčková, Eva O., additional, Krivan, Gergely, additional, McGuire, Frances K., additional, Leahy, Timothy Ronan, additional, Edgar, John David M., additional, Bakhtiar, Shahrzad, additional, Bader, Peter, additional, Rohner, Geraldine Blanchard, additional, Haerynck, Filomeen, additional, Claes, Karlien, additional, Lehmberg, Kai, additional, Müller, Ingo, additional, Farmand, Susan, additional, Fasshauer, Maria, additional, Graf, Dagmar, additional, Neves, Joao Farela, additional, Kostyuchenko, Larysa, additional, Gonzalez-Granado, Luis Ignacio, additional, Jeseňák, Miloš, additional, Carrabba, Maria, additional, Fabio, Giovanna, additional, Pignata, Claudio, additional, Giardino, Giuliana, additional, Karadağ, Ilknur Kökçü, additional, Yıldıran, Alişan, additional, Hancioglu, Gonca, additional, Králíčková, Pavlína, additional, Steinmann, Sandra, additional, Pietrucha, Barbara Maria, additional, Gernert, Michael, additional, Soomann, Maarja, additional, Witte, Torsten, additional, Markocsy, Adam, additional, Wolska-Kusnierz, Beata, additional, Randrianomenjanahary, Philippe, additional, Rouger, Jérémie, additional, Kostaridou, Stavroula, additional, Zabara, Dariia V., additional, Rodina, Yulia A., additional, and Shvets, Oksana A., additional

Published
2023
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24. Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients

Author

Riller, Quentin, primary, Fourgeaud, Jacques, additional, Bruneau, Julie, additional, De Ravin, Suk See, additional, Smith, Grace, additional, Fusaro, Mathieu, additional, Meriem, Samy, additional, Magerus, Aude, additional, Luka, Marine, additional, Abdessalem, Ghaith, additional, Lhermitte, Ludovic, additional, Jamet, Anne, additional, Six, Emmanuelle, additional, Magnani, Alessandra, additional, Castelle, Martin, additional, Lévy, Romain, additional, Lecuit, Mathilde M., additional, Fournier, Benjamin, additional, Winter, Sarah, additional, Semeraro, Michaela, additional, Pinto, Graziella, additional, Abid, Hanène, additional, Mahlaoui, Nizar, additional, Cheikh, Nathalie, additional, Florkin, Benoit, additional, Frange, Pierre, additional, Jeziorski, Eric, additional, Suarez, Felipe, additional, Sarrot-Reynauld, Françoise, additional, Nouar, Dalila, additional, Debray, Dominique, additional, Lacaille, Florence, additional, Picard, Capucine, additional, Pérot, Philippe, additional, Regnault, Béatrice, additional, Da Rocha, Nicolas, additional, de Cevins, Camille, additional, Delage, Laure, additional, Pérot, Brieuc P., additional, Vinit, Angélique, additional, Carbone, Francesco, additional, Brunaud, Camille, additional, Marchais, Manon, additional, Stolzenberg, Marie-Claude, additional, Asnafi, Vahid, additional, Molina, Thierry, additional, Rieux-Laucat, Frédéric, additional, Notarangelo, Luigi D., additional, Pittaluga, Stefania, additional, Jais, Jean Philippe, additional, Moshous, Despina, additional, Blanche, Stephane, additional, Malech, Harry, additional, Eloit, Marc, additional, Cavazzana, Marina, additional, Fischer, Alain, additional, Ménager, Mickaël M., additional, and Neven, Bénédicte, additional

Published
2023
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25. Chronic Aichi virus infection as a cause of long-lasting multi-organ involvement in patients with primary immune deficiencies

Author

Fourgeaud, Jacques, primary, Lecuit, Mathilde M, additional, Pérot, Philippe, additional, Bruneau, Julie, additional, Regnault, Beatrice, additional, Da Rocha, Nicolas, additional, Bessaud, Mael, additional, Picard, Capucine, additional, Jeziorski, Éric, additional, Fournier, Benjamin, additional, Levy, Romain, additional, Marçais, Ambroise, additional, Blanche, Stéphane, additional, Frange, Pierre, additional, Fischer, Alain, additional, Cavazzana, Marina, additional, Ferroni, Agnès, additional, Jamet, Anne, additional, Leruez-Ville, Marianne, additional, Eloit, Marc, additional, and Neven, Bénédicte, additional

Published
2023
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28. HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report

Author

Frange, Pierre, Faye, Albert, Avettand-Fenoël, Véronique, Bellaton, Erianna, Descamps, Diane, Angin, Mathieu, David, Annie, Caillat-Zucman, Sophie, Peytavin, Gilles, Dollfus, Catherine, Le Chenadec, Jerome, Warszawski, Josiane, Rouzioux, Christine, and Sáez-Cirión, Asier

Published
2016
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29. Chronic Aichi Virus Infection As a Cause of Long-Lasting Multiorgan Involvement in Patients With Primary Immune Deficiencies.

Author

Fourgeaud, Jacques, Lecuit, Mathilde M, Pérot, Philippe, Bruneau, Julie, Regnault, Beatrice, Rocha, Nicolas Da, Bessaud, Mael, Picard, Capucine, Jeziorski, Éric, Fournier, Benjamin, Levy, Romain, Marçais, Ambroise, Blanche, Stéphane, Frange, Pierre, Fischer, Alain, Cavazzana, Marina, Ferroni, Agnès, Jamet, Anne, Leruez-Ville, Marianne, and Eloit, Marc

Subjects
RNA virus infections, REVERSE transcriptase polymerase chain reaction, PHYLOGENY, SEQUENCE analysis, BIOPSY, NEPHRITIS, VIRAL load, MULTIPLE organ failure, REGULATORY T cells, RISK assessment, IMMUNOLOGICAL deficiency syndromes, SPLEEN diseases, IN situ hybridization, GENOTYPES, AGAMMAGLOBULINEMIA, DESCRIPTIVE statistics, LIVER cells, HEMATOPOIETIC stem cell transplantation, DISEASE risk factors, DISEASE complications
Abstract

Background Metagenomic next-generation sequencing (mNGS) was used to assess patients with primary or secondary immune deficiencies (PIDs and SIDs) who presented with immunopathological conditions related to immunodysregulation. Methods Thirty patients with PIDs or SIDs who presented with symptoms related to immunodysregulation and 59 asymptomatic patients with similar PIDs or SIDs were enrolled. mNGS was performed on organ biopsy. Specific Aichi virus (AiV) reverse-transcription polymerase chain reaction (RT-PCR) was used to confirm AiV infection and screen the other patients. In situ hybridization (ISH) assay was done on AiV-infected organs to identify infected cells. Virus genotype was determined by phylogenetic analysis. Results AiV sequences were detected using mNGS in tissue samples of 5 patients and by RT-PCR in peripheral samples of another patient, all of whom presented with PID and long-lasting multiorgan involvement, including hepatitis, splenomegaly, and nephritis in 4 patients. CD8+ T-cell infiltration was a hallmark of the disease. RT-PCR detected intermittent low viral loads in urine and plasma from infected patients but not from uninfected patients. Viral detection stopped after immune reconstitution obtained by hematopoietic stem cell transplantation. ISH demonstrated the presence of AiV RNA in hepatocytes (n = 1) and spleen tissue (n = 2). AiV belonged to genotype A (n = 2) or B (n = 3). Conclusions The similarity of the clinical presentation, the detection of AiV in a subgroup of patients suffering from immunodysregulation, the absence of AiV in asymptomatic patients, the detection of viral genome in infected organs by ISH, and the reversibility of symptoms after treatment argue for AiV causality. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Maintenance darunavir/ritonavir monotherapy to prevent perinatal HIV transmission, ANRS-MIE 168 MONOGEST study.

Author

Mandelbrot, Laurent, Tubiana, Roland, Frange, Pierre, Peytavin, Gilles, Chenadec, Jerome Le, Canestri, Ana, Morlat, Philippe, Brunet-Cartier, Cécile, Sibiude, Jeanne, Peretti, Delphine, Chambrin, Véronique, Chabrol, Amélie, Bui, Eida, Simon-Toulza, Caroline, Marchand, Lucie, Paul, Christelle, Delmas, Sandrine, Avettand-Fenoel, Véronique, Warszawski, Josiane, and group, the Monogest study

Subjects
RITONAVIR, RALTEGRAVIR, HIV infection transmission, DARUNAVIR, FIRST trimester of pregnancy, HIV, LIVER enzymes, TENOFOVIR
Abstract

Objectives Because NRTIs can have fetal toxicities, we evaluated a perinatal NRTI-sparing strategy to prevent perinatal HIV transmission. Our primary objective was to determine the proportion maintaining a viral load (VL) of <50 copies/mL up to delivery on darunavir/ritonavir monotherapy, without requiring treatment intensification. Methods In a one-arm, multicentre Phase 2 clinical trial, eligible patients in the first trimester of pregnancy on ART with plasma VL < 50 copies/mL received maintenance monotherapy with darunavir/ritonavir, 600/100 mg twice daily. VL was monitored monthly. ART was intensified in the case of VL > 50 copies/mL. Neonates received nevirapine prophylaxis for 14 days. Results Of 89 patients switching to darunavir/ritonavir monotherapy, 4 miscarried before 22 weeks' gestation, 2 changed treatment for elevated liver enzymes without virological failure, and 83 were evaluable for the main outcome. Six had virological failure confirmed on a repeat sample (median VL = 193 copies/mL; range 78–644), including two before switching to monotherapy. In these six cases, ART was intensified with tenofovir disoproxil fumarate/emtricitabine. The success rate was 75/83, 90.4% (95% CI, 81.9%–95.7%) considering two patients with VL missing at delivery as failures, and 77/83, 92.8% (95% CI, 84.9%–97.3%) when considering them as successes since both had undetectable VL on darunavir/ritonavir throughout pregnancy. In ITT, the last available VL before delivery was <50 copies/mL in all of the patients. There was no case of perinatal HIV transmission. Conclusions Darunavir/ritonavir maintenance monotherapy required intensification in nearly 10% of cases. This limits its widespread use, thus other regimens should be evaluated in order to limit exposure to antiretrovirals, particularly NRTIs, during pregnancy. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Setting up of a hospital Covid‐19 vaccination center: A descriptive study

Author

Wise, Scarlett, primary, Lanternier, Fanny, additional, Cotteret, Camille, additional, Chasport, Céline, additional, Juin‐Leonard, Virginie, additional, Cantat, Amélie, additional, Scemla, Anne, additional, Delage, Claire, additional, Mantz, Barbara, additional, Telion, Caroline, additional, Carli, Pierre, additional, Frange, Pierre, additional, and Cisternino, Salvatore, additional

Published
2022
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33. Correction to “Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: A national post-authorization pharmacovigilance study”

Author

Ouldali, Naïm, primary, Bagheri, Haleh, additional, Salvo, Francesco, additional, Antona, Denise, additional, Pariente, Antoine, additional, Leblanc, Claire, additional, Tebacher, Martine, additional, Micallef, Joëlle, additional, Levy, Corinne, additional, Cohen, Robert, additional, Javouhey, Etienne, additional, Bader-Meunier, Brigitte, additional, Ovaert, Caroline, additional, Renolleau, Sylvain, additional, Hentgen, Veronique, additional, Kone-Paut, Isabelle, additional, Deschamps, Nina, additional, De Pontual, Loïc, additional, Iriart, Xavier, additional, Guen, Christelle Gras-Le, additional, Angoulvant, Francois, additional, Belot, Alexandre, additional, Donzeau, Aurelie, additional, Aridi, Layal El, additional, Lety, Sophie, additional, Leboucher, Bertrand, additional, Baur, Agnes, additional, Jeusset, Lucas, additional, Selegny, Maelle, additional, Fedorczuk, Cristian, additional, Lajus, Marion, additional, Bensaid, Philippe, additional, Laoudi, Yacine, additional, Pons, Charlotte, additional, Robert, Anne-Cécile, additional, Beaucourt, Camille, additional, Richard, Muriel, additional, Goisque, Etienne, additional, Brissaud, Olivier, additional, Segretin, Pierre, additional, Molimard, Julie, additional, Orecel, Marie-Clothilde, additional, Benoit, Gregoire, additional, Bongiovanni, Lucille, additional, Guerder, Margaux, additional, Pouyau, Robin, additional, De Guillebon De Resnes, Jean-Marie, additional, Mezgueldi, Ellia, additional, Cour-Andlauer, Fleur, additional, Horvat, Come, additional, Poinsot, Pierre, additional, Frachette, Cecile, additional, Ouziel, Antoine, additional, Gillet, Yves, additional, Barrey, Catherine, additional, Brouard, Jacques, additional, Villedieu, Florence, additional, Ro, Vathanaksambath, additional, Elanga, Narcisse, additional, Gajdos, Vincent, additional, Basmaci, Romain, additional, Mutar, Hadile, additional, Rouget, Sébastien, additional, Nattes, Elodie, additional, Hau, Isabelle, additional, Biscardi, Sandra, additional, Jurdi, Houmam El, additional, Jung, Camille, additional, Semama, Denis, additional, Huet, Frederic, additional, Zoccarato, Anne-Marie, additional, Sarakbi, Mayssa, additional, Mortamet, Guillaume, additional, Bost-Bru, Cécile, additional, Bassil, Joachim, additional, Vinit, Caroline, additional, Hentgen, Véronique, additional, Leroux, Pascal, additional, Bertrand, Valérie, additional, Parrod, Caroline, additional, Craiu, Irina, additional, Durand, Philippe, additional, Tissiere, Pierre, additional, Claude, Caroline, additional, Morelle, Guillaume, additional, Guiddir, Tamazoust, additional, Borocco, Charlotte, additional, Delion, Frédérique, additional, Guillot, Camille, additional, Leteurtre, Stéphane, additional, Dubos, François, additional, Jouancastay, Mylene, additional, Martinot, Alain, additional, Voeusler, Valentine, additional, Languepin, Jeanne, additional, Garrec, Nathalie, additional, Demersay, Arnaud Chalvon, additional, Morand, Aurélie, additional, Bosdure, Emmanuelle, additional, Vanel, Noémie, additional, Ughetto, Fabrice, additional, Michel, Fabrice, additional, Caujolle, Marie, additional, Blonde, Renaud, additional, Nguyen, Jacqueline, additional, Vignaud, Olivier, additional, Masserot-Lureau, Caroline, additional, Gouraud, François, additional, Araujo, Carine, additional, Ingrao, Tara, additional, Naji, Sanaa, additional, Sehaba, Mohammed, additional, Roche, Christine, additional, Carbasse, Aurelia, additional, Milesi, Christophe, additional, Mazeghrane, Mustapha, additional, Haupt, Sandrine, additional, Schweitzer, Cyril, additional, Romefort, Benedicte, additional, Launay, Elise, additional, Guen, Christèle Gras-Le, additional, Ali, Ahmed, additional, Blot, Nathalie, additional, Tran, Antoine, additional, Rancurel, Anne, additional, Afanetti, Mickael, additional, Odorico, Sophie, additional, Talmud, Deborah, additional, Chosidow, Anais, additional, Romain, Anne-Sophie, additional, Grimprel, Emmanuel, additional, Pouletty, Marie, additional, Gaschignard, Jean, additional, Corseri, Olivier, additional, Faye, Albert, additional, Melki, Isabelle, additional, Ducrocq, Camille, additional, Benzoïd, Cherine, additional, Lokmer, Johanna, additional, Dauger, Stéphane, additional, Chomton, Maryline, additional, Deho, Anna, additional, Lebourgeois, Fleur, additional, Lesage, Fabrice, additional, Moulin, Florence, additional, Dupic, Laurent, additional, Pinhas, Yael, additional, Debray, Agathe, additional, Chalumeau, Martin, additional, Abadie, Véronique, additional, Frange, Pierre, additional, Cohen, Jeremie F, additional, Allali, Slimane, additional, Curtis, William, additional, Belhadjer, Zahra, additional, Auriau, Johanne, additional, Méot, Mathilde, additional, Houyel, Lucile, additional, Bonnet, Damien, additional, Delacourt, Christophe, additional, Meunier, Brigitte Bader, additional, Quartier, Pierre, additional, Shaim, Youssef, additional, Baril, Laurence, additional, Crommelynck, Samuel, additional, Jacquot, Baptiste, additional, Blanc, Philippe, additional, Maledon, Natacha, additional, Robert, Blandine, additional, Loeile, Camille, additional, Cazau, Clémence, additional, Loron, Gauthier, additional, Gaga, Simona, additional, Vittot, Cécile, additional, Nabhani, Loubna El, additional, Buisson, François, additional, Prudent, Muriel, additional, Flodrops, Hugues, additional, Mokraoui, Fadhila, additional, Escoda, Simon, additional, Bonnemains, Laurent, additional, Mahi, Sarah-Louisa, additional, Mertes, Clara, additional, Terzic, Joelle, additional, Helms, Julie, additional, Idier, Charlotte, additional, Chenichene, Soraya, additional, Ursulescu, Nicoleta Magdolena, additional, Beaujour, Gladys, additional, Hakim, Abdelhak, additional, Miquel, Alice, additional, Rey, Agnès, additional, Wiedermann, Arnaud, additional, Charbonneau, Anne, additional, Veauvy-Juven, Agnès, additional, Ferry, Alexandrine, additional, Mandelcwajg, Alexis, additional, Rousseau, Alix, additional, Prenant, Amandine, additional, Bourneuf, Anne-Laure, additional, Filleron, Anne, additional, Robine, Audrey, additional, Félix, Arthur, additional, Parizel, Aude, additional, Labarre, Aurélie, additional, Cantais, Aymeric, additional, Ros, Barbara, additional, Coulon, Basile, additional, Biot, Blandine, additional, Dalichoux, Bérengère, additional, Fournier, Benjamin, additional, Cagnard, Benoit, additional, Vanel, Blandine, additional, Brossier, David, additional, Ménager, Bruno, additional, Ozanne, Bruno, additional, Marie-Jeanne, Carole, additional, Bergerot, Camille, additional, Chavy, Camille, additional, Guidon, Camille, additional, Fabre, Candice, additional, Galeotti, Caroline, additional, Baker, Catherine, additional, Ballot-Schmit, Claire, additional, Belleau, Céline, additional, Charasse, Céline, additional, Favel, Caroline, additional, Toumi, Chadia, additional, Ferrandiz, Charlène, additional, Couturier, Charlotte, additional, Pouchoux, Charlotte, additional, Chomton-Cailliez, Maryline, additional, Kevorkian-Verguet, Charlotte, additional, Brunet, Clément, additional, Manteau, Céline, additional, Mougey, Clémence, additional, Santy, Coline, additional, Fitament, Coralie, additional, Petriat, Charlotte, additional, Rebelle, Charlotte, additional, Charron, Cyril, additional, Dartus, Maxime, additional, Toulorge, David, additional, Guillou-Debuisson, Cécile, additional, Bartebin, Dorann, additional, Klein, Valérie, additional, Broustal, E, additional, Desselas, E., additional, Marteau, Elodie, additional, Bouvrot, Emmanuelle, additional, Delacroix, Elise, additional, Coinde, Edeline, additional, Elnabhani, Loubna, additional, Amouyal, Elsa, additional, Chaillou, Emilie, additional, Gabilly-Bernard, Emeline, additional, Ruiz, Emilie, additional, Thibault, Emilie, additional, Robin, Emilie, additional, Darrieux, Etienne, additional, Blondel, Eva, additional, Socchi, Floriane, additional, Cazassus, François, additional, Bajolle, Fanny, additional, Lacin, Fatma, additional, Madhi, Fouad, additional, Zekre, Franck, additional, Guerin, François, additional, Boussicault, Gerald, additional, Ginies, Henri, additional, Magloire, Gnansounou, additional, Arnold, Guilhem, additional, Coulognon, Ines, additional, Sicard-Cras, Iona, additional, Kahn, Jean-Emmanuel, additional, Bordet, Jeanne, additional, Fausser, Jeanne-Lise, additional, Baleine, Jean-François, additional, Brice, Josephine, additional, Gendras, Julie, additional, Pekin, Kaan, additional, Norbert, Karine, additional, Karsenty, Clément, additional, Savary, Léa, additional, Martinat, Laurence, additional, Lesniewski, Léa, additional, Charbonnier, Lorelei, additional, Alexandre, Louise, additional, Percheron, Lucas, additional, Vincenti, Marie, additional, Lanzini, Manon, additional, Grisval, Margot, additional, Mercy, Marianne, additional, Lampin, Marie-Emilie, additional, Desgranges, Marie, additional, Duperril, Marie, additional, Orcel, Marie-Clothilde, additional, Audier, Marion, additional, Favier, Marion, additional, Carpentier, Mathieu, additional, Balcean, Mathilde, additional, Bonnet, Mathilde, additional, Jouret, Maurine, additional, Delattre, Marie, additional, Levy, Michael, additional, Valensi, Michael, additional, Shum, Mickael, additional, Dumortier, Morgane, additional, Gelin, Morgane, additional, Nemmouchi, Morgane, additional, Williaume, Morgane, additional, Sebaha, M., additional, Genetay-Stanescu, Nicoleta, additional, Giroux, Nathan, additional, Crassard, Nicolas, additional, Derridj, Neil, additional, Lachaume, Noemie, additional, Werner, Oscar, additional, Guilluy, Olivier, additional, Richer, Olivier, additional, Tirel, Olivier, additional, Pauvert, Aurianne, additional, Casha, Paul, additional, Perez, Noémie, additional, Gras, Pauline, additional, Leger, Pierre-Louis, additional, Pinchou, Marion, additional, Mornand, Pierre, additional, Largo, Prisca, additional, Ibanez, Ramona-Christina, additional, Roulland, Charlotte, additional, Albarazi, Salam Hadah, additional, Bichali, Said, additional, Faton, Sarah, additional, Schott, Amandine, additional, Walser, Sébastien, additional, Guillaume, Severine, additional, Vincent, Solene, additional, Galene-Gromez, Sophie, additional, Kozisek, Stanislas, additional, Maugard, Thierry, additional, Blanc, Thierry, additional, Navarro, Thierry, additional, Lauvray, Thomas, additional, Kovacs, Tamas, additional, Launay, Valérie, additional, Despert, Véronique, additional, Lhostis, Victoria, additional, Gall, Virginie, additional, Micaelli, Xavier, additional, Benadjaoud, Yasmine, additional, Matoussi, Zied, additional, Géniaux, Hélène, additional, Facile, Anthony, additional, Pietri, Tessa, additional, Palassin, Pascale, additional, Pinel, Sylvine, additional, Chouchana, Laurent, additional, Callot, Delphine, additional, and Boulay, Charlène, additional

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2022
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35. Update of Perinatal Human Immunodeficiency Virus Type 1 Transmission in France: Zero Transmission for 5482 Mothers on Continuous Antiretroviral Therapy From Conception and With Undetectable Viral Load at Delivery

Author

Sibiude, Jeanne, primary, Le Chenadec, Jérôme, additional, Mandelbrot, Laurent, additional, Hoctin, Alexandre, additional, Dollfus, Catherine, additional, Faye, Albert, additional, Bui, Eida, additional, Pannier, Emmanuelle, additional, Ghosn, Jade, additional, Garrait, Valerie, additional, Avettand-Fenoel, Véronique, additional, Frange, Pierre, additional, Warszawski, Josiane, additional, and Tubiana, Roland, additional

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2022
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36. Faecal carriage of multidrug-resistant bacteria and associated risk factors: results from a point prevalence study

Author

Grohs, Patrick, primary, Vilfaillot, Aurélie, additional, Zahar, Jean Ralph, additional, Barbut, Frédéric, additional, Frange, Pierre, additional, Casetta, Anne, additional, Moulin, Véronique, additional, Lawrence, Christine, additional, Baune, Patricia, additional, Bourgeois, Cléo, additional, Bouffier, Axel, additional, Laussucq, Claudine, additional, Sienzonit, Lydia, additional, Picard, Simon, additional, Podglajen, Isabelle, additional, and Kassis-Chikhani, Najiby, additional

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2022
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39. CD4 T cell decline following HIV seroconversion in individuals with and without CXCR4-tropic virus

Author

Ghosn, Jade, Bayan, Tatiana, Meixenberger, Karolin, Tran, Laurent, Frange, Pierre, d’Arminio Monforte, Antonella, Zangerle, Robert, de Mendoza, Carmen, Krastinova, Evguenia, Porter, Kholoud, Meyer, Laurence, Chaix, Marie-Laure, Kelleher, Tony, Cooper, David, Grey, Pat, Finlayson, Robert, Bloch, Mark, Kelleher, Tony, Ramacciotti, Tim, Gelgor, Linda, Cooper, David, Smith, Don, Zangerle, Robert, Gill, John, Lutsar, Irja, Chêne, Geneviève, Dabis, Francois, Thiebaut, Rodolphe, Costagliola, Dominique, Guiguet, Marguerite, Vanhems, Philippe, Chaix, Marie-Laure, Ghosn, Jade, Meyer, Laurence, Boufassa, Faroudy, Hamouda, Osamah, Meixenberger, Karolin, Bannert, Norbert, Bartmeyer, Barbara, Antoniadou, Anastasia, Chrysos, Georgios, Daikos, Georgios L., Touloumi, Giota, Pantazis, Nikos, Katsarou, Olga, Rezza, Giovanni, Dorrucci, Maria, Monforte, Antonella d’Arminio, De Luca, Andrea, Prins, Maria, Geskus, Ronald, van der Helm, Jannie, Schuitemaker, Hanneke, Sannes, Mette, Brubakk, Oddbjorn, Kran, Anne-Marte Bakken, Rosinska, Magdalena, Muga, Roberto, Tor, Jordi, de Olalla, Patricia Garcia, Cayla, Joan, del Amo, Julia, Moreno, Santiago, Monge, Susana, Del Amo, Julia, del Romero, Jorge, Pérez-Hoyos, Santiago, Sönnerborg, Anders, Bucher, Heiner C., Günthard, Huldrych, Scherrer, Alexandra, Malyuta, Ruslan, Murphy, Gary, Porter, Kholoud, Johnson, Anne, Phillips, Andrew, Babiker, Abdel, Pillay, Deenan, Morrison, Charles, Salata, Robert, Mugerwa, Roy, Chipato, Tsungai, Price, Matt A., Gilmour, Jill, Kamali, Anatoli, and Karita, Etienne

Published
2017
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40. A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency

Author

Neven, Bénédicte, Mamessier, Emilie, Bruneau, Julie, Kaltenbach, Sophie, Kotlarz, Daniel, Suarez, Felipe, Masliah-Planchon, Julien, Billot, Katy, Canioni, Danielle, Frange, Pierre, Radford-Weiss, Isabelle, Asnafi, Vahid, Murugan, Dhaarini, Bole, Christine, Nitschke, Patrick, Goulet, Olivier, Casanova, Jean-Laurent, Blanche, Stéphane, Picard, Capucine, Hermine, Olivier, Rieux-Laucat, Frederic, Brousse, Nicole, Davi, Frederic, Baud, Véronique, Klein, Christoph, Nadel, Bertrand, Ruemmele, Frank, and Fischer, Alain

Published
2013
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41. Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: A national post-authorization pharmacovigilance study

Author

Ouldali, Naïm, primary, Bagheri, Haleh, additional, Salvo, Francesco, additional, Antona, Denise, additional, Pariente, Antoine, additional, Leblanc, Claire, additional, Tebacher, Martine, additional, Micallef, Joëlle, additional, Levy, Corinne, additional, Cohen, Robert, additional, Javouhey, Etienne, additional, Bader-Meunier, Brigitte, additional, Ovaert, Caroline, additional, Renolleau, Sylvain, additional, Hentgen, Veronique, additional, Kone-Paut, Isabelle, additional, Deschamps, Nina, additional, De Pontual, Loïc, additional, Iriart, Xavier, additional, Guen, Christelle Gras-Le, additional, Angoulvant, François, additional, Belot, Alexandre, additional, Donzeau, Aurelie, additional, El Aridi, Layal, additional, Lety, Sophie, additional, Leboucher, Bertrand, additional, Baur, Agnes, additional, Jeusset, Lucas, additional, Selegny, Maelle, additional, Fedorczuk, Cristian, additional, Lajus, Marion, additional, Bensaid, Philippe, additional, Laoudi, Yacine, additional, Pons, Charlotte, additional, Robert, Anne-Cécile, additional, Beaucourt, Camille, additional, Richard, Muriel, additional, Goisque, Etienne, additional, Brissaud, Olivier, additional, Segretin, Pierre, additional, Molimard, Julie, additional, Orecel, Marie-Clothilde, additional, Benoit, Gregoire, additional, Bongiovanni, Lucille, additional, Guerder, Margaux, additional, Pouyau, Robin, additional, De Guillebon De Resnes, Jean-Marie, additional, Mezgueldi, Ellia, additional, Cour-Andlauer, Fleur, additional, Horvat, Come, additional, Poinsot, Pierre, additional, Frachette, Cecile, additional, Ouziel, Antoine, additional, Gillet, Yves, additional, Barrey, Catherine, additional, Brouard, Jacques, additional, Villedieu, Florence, additional, Ro, Vathanaksambath, additional, Elanga, Narcisse, additional, Gajdos, Vincent, additional, Basmaci, Romain, additional, Mutar, Hadile, additional, Rouget, Sébastien, additional, Nattes, Elodie, additional, Hau, Isabelle, additional, Biscardi, Sandra, additional, El Jurdi, Houmam, additional, Jung, Camille, additional, Semama, Denis, additional, Huet, Frederic, additional, Zoccarato, Anne-Marie, additional, Sarakbi, Mayssa, additional, Mortamet, Guillaume, additional, Bost-Bru, Cécile, additional, Bassil, Joachim, additional, Vinit, Caroline, additional, Hentgen, Véronique, additional, Leroux, Pascal, additional, Bertrand, Valérie, additional, Parrod, Caroline, additional, Craiu, Irina, additional, Durand, Philippe, additional, Tissiere, Pierre, additional, Claude, Caroline, additional, Morelle, Guillaume, additional, Guiddir, Tamazoust, additional, Borocco, Charlotte, additional, Delion, Frédérique, additional, Guillot, Camille, additional, Leteurtre, Stéphane, additional, Dubos, François, additional, Jouancastay, Mylene, additional, Martinot, Alain, additional, Voeusler, Valentine, additional, Languepin, Jeanne, additional, Garrec, Nathalie, additional, Demersay, Arnaud Chalvon, additional, Morand, Aurélie, additional, Bosdure, Emmanuelle, additional, Vanel, Noémie, additional, Ughetto, Fabrice, additional, Michel, Fabrice, additional, Caujolle, Marie, additional, Blonde, Renaud, additional, Nguyen, Jacqueline, additional, Vignaud, Olivier, additional, Masserot-Lureau, Caroline, additional, Gouraud, François, additional, Araujo, Carine, additional, Ingrao, Tara, additional, Naji, Sanaa, additional, Sehaba, Mohammed, additional, Roche, Christine, additional, Carbasse, Aurelia, additional, Milesi, Christophe, additional, Mazeghrane, Mustapha, additional, Haupt, Sandrine, additional, Schweitzer, Cyril, additional, Romefort, Benedicte, additional, Launay, Elise, additional, Guen, Christèle Gras-Le, additional, Ali, Ahmed, additional, Blot, Nathalie, additional, Tran, Antoine, additional, Rancurel, Anne, additional, Afanetti, Mickael, additional, Odorico, Sophie, additional, Talmud, Deborah, additional, Chosidow, Anais, additional, Romain, Anne-Sophie, additional, Grimprel, Emmanuel, additional, Pouletty, Marie, additional, Gaschignard, Jean, additional, Corseri, Olivier, additional, Faye, Albert, additional, Melki, Isabelle, additional, Ducrocq, Camille, additional, Benzoïd, Cherine, additional, Lokmer, Johanna, additional, Dauger, Stéphane, additional, Chomton, Maryline, additional, Deho, Anna, additional, Lebourgeois, Fleur, additional, Lesage, Fabrice, additional, Moulin, Florence, additional, Dupic, Laurent, additional, Pinhas, Yael, additional, Debray, Agathe, additional, Chalumeau, Martin, additional, Abadie, Véronique, additional, Frange, Pierre, additional, Cohen, Jeremie F, additional, Allali, Slimane, additional, Curtis, William, additional, Belhadjer, Zahra, additional, Auriau, Johanne, additional, Méot, Mathilde, additional, Houyel, Lucile, additional, Bonnet, Damien, additional, Delacourt, Christophe, additional, Bader Meunier, Brigitte, additional, Quartier, Pierre, additional, Shaim, Youssef, additional, Baril, Laurence, additional, Crommelynck, Samuel, additional, Jacquot, Baptiste, additional, Blanc, Philippe, additional, Maledon, Natacha, additional, Robert, Blandine, additional, Loeile, Camille, additional, Cazau, Clémence, additional, Loron, Gauthier, additional, Gaga, Simona, additional, Vittot, Cécile, additional, El Nabhani, Loubna, additional, Buisson, François, additional, Prudent, Muriel, additional, Flodrops, Hugues, additional, Mokraoui, Fadhila, additional, Escoda, Simon, additional, Bonnemains, Laurent, additional, Mahi, Sarah-Louisa, additional, Mertes, Clara, additional, Terzic, Joelle, additional, Helms, Julie, additional, Idier, Charlotte, additional, Chenichene, Soraya, additional, Magdolena Ursulescu, Nicoleta, additional, Beaujour, Gladys, additional, Hakim, Abdelhak, additional, Miquel, Alice, additional, Rey, Agnès, additional, Wiedermann, Arnaud, additional, Charbonneau, Anne, additional, Veauvy-Juven, Agnès, additional, Ferry, Alexandrine, additional, Mandelcwajg, Alexis, additional, Rousseau, Alix, additional, Prenant, Amandine, additional, Bourneuf, Anne-Laure, additional, Filleron, Anne, additional, Robine, Audrey, additional, Félix, Arthur, additional, Parizel, Aude, additional, Labarre, Aurélie, additional, Cantais, Aymeric, additional, Ros, Barbara, additional, Coulon, Basile, additional, Biot, Blandine, additional, Dalichoux, Bérengère, additional, Fournier, Benjamin, additional, Cagnard, Benoit, additional, Vanel, Blandine, additional, Brossier, David, additional, Ménager, Bruno, additional, Ozanne, Bruno, additional, Marie-Jeanne, Carole, additional, Bergerot, Camille, additional, Chavy, Camille, additional, Guidon, Camille, additional, Fabre, Candice, additional, Galeotti, Caroline, additional, Baker, Catherine, additional, Ballot-Schmit, Claire, additional, Belleau, Céline, additional, Charasse, Céline, additional, Favel, Caroline, additional, Toumi, Chadia, additional, Ferrandiz, Charlène, additional, Couturier, Charlotte, additional, Pouchoux, Charlotte, additional, Chomton-Cailliez, Maryline, additional, Kevorkian-Verguet, Charlotte, additional, Brunet, Clément, additional, Manteau, Céline, additional, Mougey, Clémence, additional, Santy, Coline, additional, Fitament, Coralie, additional, Petriat, Charlotte, additional, Rebelle, Charlotte, additional, Charron, Cyril, additional, Dartus, Maxime, additional, Toulorge, David, additional, Guillou-Debuisson, Cécile, additional, Bartebin, Dorann, additional, Klein, Valérie, additional, Broustal, E, additional, Desselas, E, additional, Marteau, Elodie, additional, Bouvrot, Emmanuelle, additional, Delacroix, Elise, additional, Coinde, Edeline, additional, Elnabhani, Loubna, additional, Amouyal, Elsa, additional, Chaillou, Emilie, additional, Gabilly-Bernard, Emeline, additional, Ruiz, Emilie, additional, Thibault, Emilie, additional, Robin, Emilie, additional, Darrieux, Etienne, additional, Blondel, Eva, additional, Socchi, Floriane, additional, Cazassus, François, additional, Bajolle, Fanny, additional, Lacin, Fatma, additional, Madhi, Fouad, additional, Zekre, Franck, additional, Guerin, François, additional, Boussicault, Gerald, additional, Ginies, Henri, additional, Magloire, Gnansounou, additional, Arnold, Guilhem, additional, Coulognon, Ines, additional, Sicard-Cras, Iona, additional, Kahn, Jean-Emmanuel, additional, Bordet, Jeanne, additional, Fausser, Jeanne-Lise, additional, Baleine, Jean-François, additional, Brice, Josephine, additional, Gendras, Julie, additional, Pekin, Kaan, additional, Norbert, Karine, additional, Karsenty, Clément, additional, Savary, Léa, additional, Martinat, Laurence, additional, Lesniewski, Léa, additional, Charbonnier, Lorelei, additional, Alexandre, Louise, additional, Percheron, Lucas, additional, Vincenti, Marie, additional, Lanzini, Manon, additional, Grisval, Margot, additional, Mercy, Marianne, additional, Lampin, Marie-Emilie, additional, Desgranges, Marie, additional, Duperril, Marie, additional, Orcel, Marie-Clothilde, additional, Audier, Marion, additional, Favier, Marion, additional, Carpentier, Mathieu, additional, Balcean, Mathilde, additional, Bonnet, Mathilde, additional, Jouret, Maurine, additional, Delattre, Marie, additional, Levy, Michael, additional, Valensi, Michael, additional, Shum, Mickael, additional, Dumortier, Morgane, additional, Gelin, Morgane, additional, Nemmouchi, Morgane, additional, Williaume, Morgane, additional, Sebaha, M, additional, Genetay-Stanescu, Nicoleta, additional, Giroux, Nathan, additional, Crassard, Nicolas, additional, Derridj, Neil, additional, Lachaume, Noemie, additional, Werner, Oscar, additional, Guilluy, Olivier, additional, Richer, Olivier, additional, Tirel, Olivier, additional, Pauvert, Aurianne, additional, Casha, Paul, additional, Perez, Noémie, additional, Gras, Pauline, additional, Leger, Pierre-Louis, additional, Pinchou, Marion, additional, Mornand, Pierre, additional, Largo, Prisca, additional, Ibanez, Ramona-Christina, additional, Roulland, Charlotte, additional, Hadah Albarazi, Salam, additional, Bichali, Said, additional, Faton, Sarah, additional, Schott, Amandine, additional, Walser, Sébastien, additional, Guillaume, Severine, additional, Vincent, Solene, additional, Galene-Gromez, Sophie, additional, Kozisek, Stanislas, additional, Maugard, Thierry, additional, Blanc, Thierry, additional, Navarro, Thierry, additional, Lauvray, Thomas, additional, Kovacs, Tamas, additional, Launay, Valérie, additional, Despert, Véronique, additional, Lhostis, Victoria, additional, Gall, Virginie, additional, Micaelli, Xavier, additional, Benadjaoud, Yasmine, additional, Matoussi, Zied, additional, Géniaux, Hélène, additional, Facile, Anthony, additional, Pietri, Tessa, additional, Palassin, Pascale, additional, Pinel, Sylvine, additional, Chouchana, Laurent, additional, Callot, Delphine, additional, and Boulay, Charlène, additional

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2022
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42. An appraisal of the frequency and severity of noninfectious manifestations in primary immunodeficiencies: A study of a national retrospective cohort of 1375 patients over 10 years

Author

Alligon, Mickaël, primary, Mahlaoui, Nizar, additional, Courteille, Virginie, additional, Costes, Laurence, additional, Afonso, Veronica, additional, Randrianomenjanahary, Philippe, additional, de Vergnes, Nathalie, additional, Ranohavimparany, Anja, additional, Vo, Duy, additional, Hafsa, Inès, additional, Bach, Perrine, additional, Benoit, Vincent, additional, Garcelon, Nicolas, additional, Fischer, Alain, additional, Abou-Chahla, Wadih, additional, Adoue, Daniel, additional, Aladjidi, Nathalie, additional, Armari-Alla, Corinne, additional, Barlogis, Vincent, additional, Bayart, Sophie, additional, Bertrand, Yves, additional, Blanche, Stéphane, additional, Bodet, Damien, additional, Bonnotte, Bernard, additional, Borie, Raphaël, additional, Boutard, Patrick, additional, Boutboul, David, additional, Briandet, Claire, additional, Brion, Jean-Paul, additional, Brouard, Jacques, additional, Carausu, Liana, additional, Castelle, Martin, additional, Cathebras, Pascal, additional, Catherinot, Emilie, additional, Cheikh, Nathalie, additional, Cheminant, Morgane, additional, Cohen-Beaussant, Sarah, additional, Comont, Thibault, additional, Couderc, Louis-Jean, additional, Cougoul, Pierre, additional, Couillault, Gérard, additional, Crevon, Lionel, additional, Demonchy, Elisa, additional, Deville, Anne, additional, Devoldere, Catherine, additional, Dore, Eric, additional, Dulieu, Fabienne, additional, Durieu, Isabelle, additional, Entz-Werle, Natacha, additional, Fieschi, Claire, additional, Fouyssac, Fanny, additional, Frange, Pierre, additional, Gajdos, Vincent, additional, Galicier, Lionel, additional, Gandemer, Virginie, additional, Gardembas, Martine, additional, Gaud, Catherine, additional, Grosbois, Bernard, additional, Guffroy, Aurélien, additional, Guitton, Corinne, additional, Guillerm, Gaëlle, additional, Hachulla, Eric, additional, Hamidou, Mohamed, additional, Haro, Sophie, additional, Hatchuel, Yves, additional, Hermine, Olivier, additional, Hoarau, Cyrille, additional, Hot, Arnaud, additional, Humbert, Sébastien, additional, Jaccard, Arnaud, additional, Jais, Jean-Philippe, additional, Jannier, Sarah, additional, Jacquot, Serge, additional, Jaussaud, Roland, additional, Jeandel, Pierre-Yves, additional, Jeziorski, Eric, additional, Kebaili, Kamila, additional, Korganow, Anne-Sophie, additional, Lambotte, Olivier, additional, Lanternier, Fanny, additional, Larroche, Claire, additional, Launay, David, additional, Le Moigne, Emmanuelle, additional, Le Quellec, Alain, additional, Le Moing, Vincent, additional, Lebranchu, Yvon, additional, Lecuit, Marc, additional, Lefèvre, Guillaume, additional, Lelièvre, Jean-Daniel, additional, Lemal, Richard, additional, Li-Thiao-Te, Valérie, additional, Lortholary, Olivier, additional, Luca, Luminita, additional, Mallebranche, Coralie, additional, Malphettes, Marion, additional, Marie-Cardine, Aude, additional, Martin-Silva, Nicolas, additional, Masseau, Agathe, additional, Mazingue, Françoise, additional, Merlin, Etienne, additional, Michel, Gérard, additional, Millot, Frédéric, additional, Miot, Charline, additional, Monlibert, Béatrice, additional, Monpoux, Fabrice, additional, Moshous, Despina, additional, Mouthon, Luc, additional, Münzer, Martine, additional, Navarro, Robert, additional, Neven, Bénédicte, additional, Nouar, Dalila, additional, Nove-Josserand, Raphaële, additional, Oksenhendler, Eric, additional, Ouachée-Chardin, Marie, additional, Pagnier, Anne, additional, Pasquet, Marlène, additional, Pellier, Isabelle, additional, Perel, Yves, additional, Perlat, Antoinette, additional, Piguet, Christophe, additional, Plantaz, Dominique, additional, Rivière, Sophie, additional, Roblot, Pascal, additional, Rohrlich, Pierre-Simon, additional, Royer, Bruno, additional, Salle, Valéry, additional, Sarrot-Reynauld, Françoise, additional, Servettaz, Amélie, additional, Stephan, Jean-Louis, additional, Schleinitz, Nicolas, additional, Sokol, Harry, additional, Suarez, Felipe, additional, Swiader, Laure, additional, Taque, Sophie, additional, Thomas, Caroline, additional, Tournilhac, Olivier, additional, Thumerelle, Caroline, additional, Vannier, Jean-Pierre, additional, and Viallard, Jean-François, additional

Published
2022
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48. Update of Perinatal Human Immunodeficiency Virus Type 1 Transmission in France: Zero Transmission for 5482 Mothers on Continuous Antiretroviral Therapy From Conception and With Undetectable Viral Load at Delivery.

Author

Sibiude, Jeanne, Chenadec, Jérôme Le, Mandelbrot, Laurent, Hoctin, Alexandre, Dollfus, Catherine, Faye, Albert, Bui, Eida, Pannier, Emmanuelle, Ghosn, Jade, Garrait, Valerie, Avettand-Fenoel, Véronique, Frange, Pierre, Warszawski, Josiane, and Tubiana, Roland

Subjects
HIV prevention, RESEARCH, HEALTH services accessibility, CONFIDENCE intervals, CONCEPTION, VIRAL load, GESTATIONAL age, HIGHLY active antiretroviral therapy, PRE-exposure prophylaxis, TREATMENT effectiveness, DESCRIPTIVE statistics, VERTICAL transmission (Communicable diseases), LONGITUDINAL method, PREGNANCY
Abstract

Background Antiretroviral therapy (ART) is remarkably effective in preventing perinatal transmission (PT) of HIV-1. We evaluated the PT rate in a population of women with widespread access to ART before conception. Methods The analysis included 14 630 women with HIV-1 who delivered from 2000 to 2017 at centers participating in the nationwide prospective multicenter French Perinatal Cohort (ANRS-EPF). PT was analyzed according to time period, timing of ART initiation, maternal plasma viral load (pVL), and gestational age at birth. No infants were breastfed, and all received neonatal prophylaxis. Results PT decreased between 3 periods, from 1.1% in 2000–2005 (58/5123) to 0.7% in 2006–2010 (30/4600) and to 0.2% in 2011–2017 (10/4907; P <.001). Restriction of the analysis to the 6316/14 630 (43%) women on ART at conception, PT decreased from 0.42% (6/1434) in 2000–2005 to 0.03% (1/3117) in 2011–2017 (P =.007). Among women treated at conception, if maternal pVL was undetectable near delivery, no PT was observed regardless of the ART combination [95%CI 0-0.07] (0/5482). Among women who started ART during pregnancy and with undetectable pVL near delivery, PT was 0.57% [95%CI 0.37-0.83] (26/4596). Among women treated at conception but with a detectable pVL near delivery, PT was 1.08% [95%CI 0.49-2.04] (9/834). We also qualitatively described 10 cases of transmission that occurred during the 2011–2017 period. Conclusions In a setting with free access to ART, monthly pVL assessment, infant ART prophylaxis, and in the absence of breastfeeding, suppressive ART initiated before pregnancy and continued throughout pregnancy can reduce PT of HIV to almost zero. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Setting up of a hospital Covid‐19 vaccination center: A descriptive study.

Author

Wise, Scarlett, Lanternier, Fanny, Cotteret, Camille, Chasport, Céline, Juin‐Leonard, Virginie, Cantat, Amélie, Scemla, Anne, Delage, Claire, Mantz, Barbara, Telion, Caroline, Carli, Pierre, Frange, Pierre, and Cisternino, Salvatore

Subjects
COVID-19 vaccines, COVID-19, SARS-CoV-2, COVID-19 pandemic, MEDICAL personnel
Abstract

Background and Aims: The coronavirus pandemic challenged countries worldwide in a race against contaminations and variants. Vaccination campaigns were the answer to such an infectious spread. This descriptive study presents the organizational process of the setting up of a Covid‐19 vaccination center in a French University Hospital in January 2021, the issues encountered along the way and assessment of adaptability. Methods: Three major stakeholders: SARS CoV‐2 crisis referent, referring vaccination medical doctor and referring vaccination pharmacist retraced key moments and identified issues encountered during the setting up of the vaccination center and its long term maintenance, threw a series of meetings. Records of crisis and periodic meetings that took place threw out the vaccination campaign were consulted. Results: A multidisciplinary crisis steering committee with nine different professionals was created January 3. Logistics for the vaccination center opening were discussed: location, informatics, appointment‐scheduling, pharmaceutical circuit, internal circuit, human resources, and information communication. The vaccination center was ready to welcome healthcare workers in less than 24 h on January 4. The first month, 2757 1st shots were administered, leading up to a total of 9167 1st shots during 6 months of activity. From January to June 2021, the multidisciplinary group dealt and adapted its processes to challenging and unexpected situations. Indeed, issues encountered with Pfizer BioNTech's and AstraZeneca's vaccine, were: supply shortages, vaccine manipulation, targeted populations, pharmacovigilance, and general communication. Conclusion: This descriptive study provides an exclusive insight on how a hospital vaccination center was organized and adapted during Covid‐19 pandemic to ensure healthcare workers' security and resilience, and to protect high risk patients of severe Covid‐19 infection. [ABSTRACT FROM AUTHOR]

Published
2023
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