34,165 results on '"Francois P."'
Search Results
2. Emerging South African smart cities: Data security and privacy risks and challenges
- Author
-
Francois P. Cornelius and Shandre K. Jansen van Rensburg
- Subjects
cyberattacks ,data breaches ,data security and privacy risks ,data security ,emerging smart city ,information security risks ,information security ,privacy ,smart city ,Management information systems ,T58.6-58.62 ,Information theory ,Q350-390 - Abstract
Background: Smart cities leverage advanced technologies such as the Internet of Things (IoT), fifth generation (5G) networks, and data analytics to enhance citizens’ quality of life, focussing on creating efficient, functional, and eco-friendly urban environments. While these initiatives offer significant benefits, there are ongoing concerns about data security and privacy. Objectives: This article investigates the data security and privacy risks and challenges in emerging South African smart cities. The objectives are to identify these risks, assess the effectiveness of current security measures, and contextualise these vulnerabilities within the South African and global contexts. Method: A qualitative approach was adopted, involving virtual interviews with 20 Subject Matter Experts (SMEs) through purposive and snowball sampling. The raw data were thematically analysed, revealing significant themes. Results: Emerging South African smart cities face several risks and challenges, including poor governance, a shortage of skills, a lack of awareness and training, insufficient funding, and a combination of these factors. Conclusion: The research highlights the importance of safeguarding individuals’ data and privacy in the context of smart cities, advocating the need for proactive measures to address these concerns. Contribution: This article promotes interdisciplinary dialogue, leading to more comprehensive solutions. In addition, exploring data security and privacy in emerging smart cities aids in understanding the implications of information management practices. Although the article focuses on emerging South African smart cities, the challenges discussed have global relevance.
- Published
- 2024
- Full Text
- View/download PDF
3. Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers
- Author
-
Françoise Derouane, Manon Desgres, Camilla Moroni, Jérôme Ambroise, Martine Berlière, Mieke R. Van Bockstal, Christine Galant, Cédric van Marcke, Marianela Vara-Messler, Stefan J. Hutten, Jos Jonkers, Larissa Mourao, Colinda L. G. J. Scheele, Francois P. Duhoux, and Cyril Corbet
- Subjects
Early triple negative breast cancer ,Neoadjuvant chemotherapy ,Organoids ,Metabolism ,Glycolysis ,Therapy resistance ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Neoadjuvant chemotherapy (NAC) is the standard of care for patients with early-stage triple negative breast cancers (TNBC). However, more than half of TNBC patients do not achieve a pathological complete response (pCR) after NAC, and residual cancer burden (RCB) is associated with dismal long-term prognosis. Understanding the mechanisms underlying differential treatment outcomes is therefore critical to limit RCB and improve NAC efficiency. Methods Human TNBC cell lines and patient-derived organoids were used in combination with real-time metabolic assays to evaluate the effect of NAC (paclitaxel and epirubicin) on tumor cell metabolism, in particular glycolysis. Diagnostic biopsies (pre-NAC) from patients with early TNBC were analyzed by bulk RNA-sequencing to evaluate the predictive value of a glycolysis-related gene signature. Results Paclitaxel induced a consistent metabolic switch to glycolysis, correlated with a reduced mitochondrial oxidative metabolism, in TNBC cells. In pre-NAC diagnostic biopsies from TNBC patients, glycolysis was found to be upregulated in non-responders. Furthermore, glycolysis inhibition greatly improved response to NAC in TNBC organoid models. Conclusions Our study pinpoints a metabolic adaptation to glycolysis as a mechanism driving resistance to NAC in TNBC. Our data pave the way for the use of glycolysis-related genes as predictive biomarkers for NAC response, as well as the development of inhibitors to overcome this glycolysis-driven resistance to NAC in human TNBC patients.
- Published
- 2024
- Full Text
- View/download PDF
4. Fundamental Modeling of the Switching Transition in High-Speed Power Electronics
- Author
-
Francois P. Du Toit and Ivan W. Hofsajer
- Subjects
Wide bandgap (WBG) ,ultra wide bandgap (UWBG) ,zero overvoltage switching (ZOS) ,oscillation suppression methods ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Recent advances in semiconductor technology have paved the way for ultra-fast switching capabilities. This increase in switching speed enhances efficiency, power density, and frequency but also increases overvoltage oscillations at the switching node. Existing methods that effectively suppress this overvoltage include slower switching and minimisation of inductance, but unfortunately, these methods become very difficult to implement as the switching speed increases. A new oscillation suppression method, Zero Overvoltage Switching (ZOS), has previously been developed in which the overvoltage is suppressed very effectively by increasing both the switching speed and inductance, contrary to mainstream expectation. This is the only oscillation suppression method that becomes more effective as the switching speed increases and is not constrained by the minimisation of inductance, yet this method has not gained widespread recognition. This is expected because Zero Overvoltage Switching is not explained within the context of existing knowledge, and the argument for implementing it is difficult in the very narrow window where the advantages outweigh the effort. This research develops a generalised fundamental model to better understand Zero Overvoltage Switching by describing the mechanics of fast and slow switching events. The model is also able to provide insights that lead to methods to apply Zero Overvoltage Switching over a broader range of voltages and currents.
- Published
- 2024
- Full Text
- View/download PDF
5. A Review of the Experimental Performance of Turn-Off Methods in Wide Bandgap Semiconductors
- Author
-
Francois P. du Toit and Ivan W. Hofsajer
- Subjects
Experimental comparison ,fast-switching devices ,oscillation suppression methods ,wide bandgap (WBG) devices ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Wide Bandgap devices are becoming more popular because of their higher switching performance. However, this higher performance comes at the cost of increased susceptibility to parasitic effects and leads to problems such as voltage overshoot and ringing of the switching node. Many strategies have been described in the literature that suppress these undesirable effects and enable faster switching. Generally, the literature describes the effectiveness of a new suppression method by experimentally comparing the outcomes when the strategy is used versus when it is not used. However there is no study that compares experimental results of the many different reported strategies with each other. This work is a meta-analysis of previously reported experimental results of WBG devices that compare the different reported strategies against one another. This shows which class of strategy holds the most promise for future development. The data presented also enables future strategies to be benchmarked against the current state-of-the-art.
- Published
- 2024
- Full Text
- View/download PDF
6. Paclitaxel plus carboplatin and durvalumab with or without oleclumab for women with previously untreated locally advanced or metastatic triple-negative breast cancer: the randomized SYNERGY phase I/II trial
- Author
-
Laurence Buisseret, Delphine Loirat, Philippe Aftimos, Christian Maurer, Kevin Punie, Véronique Debien, Paulus Kristanto, Daniel Eiger, Anthony Goncalves, François Ghiringhelli, Donatienne Taylor, Florent Clatot, Tom Van den Mooter, Jean-Marc Ferrero, Hervé Bonnefoi, Jean-Luc Canon, Francois P. Duhoux, Laura Mansi, Renaud Poncin, Philippe Barthélémy, Nicolas Isambert, Zoë Denis, Xavier Catteau, Roberto Salgado, Elisa Agostinetto, Evandro de Azambuja, Françoise Rothé, Ligia Craciun, David Venet, Emanuela Romano, John Stagg, Marianne Paesmans, Denis Larsimont, Christos Sotiriou, Michail Ignatiadis, and Martine Piccart-Gebhart
- Subjects
Science - Abstract
Abstract Chemo-immunotherapy is the first-line standard of care for patients with PD-L1 positive metastatic triple-negative breast cancer (mTNBC). SYNERGY (NCT03616886) is a dose-finding phase I and a randomized phase II, open-label trial evaluating if targeting the immunosuppressive adenosine pathway can enhance the antitumor activity of chemo-immunotherapy. The phase I part included 6 patients with untreated locally-advanced or mTNBC to determine the safety and recommended phase II dose of the anti-CD73 antibody oleclumab in combination with the anti-PD-L1 durvalumab and 12 cycles of weekly carboplatin and paclitaxel. In the phase II part, 127 women were randomized 1:1 to receive chemo-immunotherapy, with (arm A) or without (arm B) oleclumab. The primary endpoint was the clinical benefit rate at week 24, defined as stable disease, partial or complete response per RECIST v1.1. Secondary endpoints included objective response rate, duration of response, survival outcomes (progression-free survival and overall survival), and safety. The trial did not meet its primary endpoint, as the 24-week clinical benefit rate was not significantly improved by adding oleclumab (43% vs. 44%, p = 0.61). Exploratory median progression-free survival was 5.9 months in arm A as compared to 7.0 months in arm B (p = 0.90). The safety profile was manageable in both arms.
- Published
- 2023
- Full Text
- View/download PDF
7. Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection
- Author
-
Maria Letizia Potenza, Stefan Blankvoort, Miguel M. Carvalho, Joachim S. Grimstvedt, Valentina Di Maria, Kristian Moan, Rajeevkumar Raveendran Nair, Marcus S. Flatset, Qiangwei Zhang, Laurent F. Thomas, Francois P. Pauzin, Rodolfo Da Silva Mazzarini Baldinotti, Giulia Quattrocolo, Clive R. Bramham, Pål Sætrom, Menno P. Witter, and Clifford G. Kentros
- Subjects
rAAVs ,dentate gyrus ,genetic tool ,chromatin immunoprecipitation ,stereotaxic injection ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Accurate investigations of neural circuitry require specific genetic access to individual circuit elements, i.e., the myriad neuronal cell-types in the brain. However, native promoters cannot achieve this because while most genes are expressed in the brain, few are expressed in a single neuronal cell-type. We recently used enhancers, the subcomponents of the transcriptional apparatus which tell promoters when and where to express, combined with heterologous minimal promoters to increase specificity of transgene expression, an approach we call Enhancer-Driven Gene Expression (EDGE). As we discuss, EDGE is a marked improvement in specificity over native promoters, but still requires careful anatomical analysis to avoid off-target effects. In this study we present a more complete set of genomic markers from the mouse brain and characterize a novel EDGE viral vector capable of specifically driving expression in distinct subtypes of hippocampal neurons, even though it can express in other cell-types elsewhere. The advent of cell-type specific viral tools in wild-type animals provides a powerful strategy for neural circuit investigation and holds promise for studies using animal models for which transgenic tools are not available.
- Published
- 2024
- Full Text
- View/download PDF
8. Jesus as the personification of God’s wisdom in Matthew
- Author
-
Francois P. Viljoen
- Subjects
wisdom ,lady wisdom ,attributes of god ,gospel of matthew ,wise ,concealment ,revelation ,mystery ,sophia ,Practical Theology ,BV1-5099 ,Practical religion. The Christian life ,BV4485-5099 - Abstract
This article investigates the attribute of God’s wisdom in Matthew’s Gospel as personified in the ministry of his Son, Jesus. This Gospel identifies Jesus as ‘Immanuel’. He is ‘God with us’. The focus falls on several statements exhibiting wisdom motifs that are either uttered by or ascribed to Jesus. These statements are quite puzzling and continue to evoke scholarly discussion. The central theoretical argument of this article is that these statements cannot be fully understood without considering the echoes of the Jewish context exhibited in them. The objective of his investigation is to demonstrate how the recognition of similarities between the statements in Matthew and in Jewish literature contribute towards the understanding of wisdom statements in the Matthean Gospel. This article therefore begins by identifying key wisdom motifs within Jewish tradition, followed by an investigation of wisdom sayings in Matthew. Parallels in Luke are considered to sharpen peculiarities of Matthew’s narration. From this investigation it became clear that the ministry of Jesus in Matthew is met with similar reactions as that of Wisdom in Jewish literature. The article accentuates a significant dimension of Matthew’s Christology. Matthew vindicates Jesus against his opponents and justifies Jesus’ acceptance within the Matthean community. For this community, he is not only recognised as wise teacher, but even the one who reveals and personifies wisdom. As ‘Immanuel’, he presents the attribute of God’s wisdom. Contribution: This article contributes to the ongoing scholarly discussion of several puzzling and seemingly obscure statements echoing wisdom motifs, either attributed to or uttered by Jesus.
- Published
- 2024
- Full Text
- View/download PDF
9. Temporal Dynamics of Plasma Catecholamines, Metabolic and Immune Markers, and the Corticosterone:DHEA Ratio in Farmed Crocodiles before and after an Acute Stressor
- Author
-
Andre A. Swanepoel, Christoff Truter, Francois P. Viljoen, Jan G. Myburgh, and Brian H. Harvey
- Subjects
farmed crocodiles ,stress response ,monoamines ,heterophil-to-lymphocyte ratio (HLR) ,corticosterone-to-dehydroepiandrosterone (CORT:DHEA) ratio ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
Commercial crocodilian farms face significant economic and livestock losses attributed to stress, which may be linked to their adopted husbandry practices. The development of appropriate and modernized husbandry guidelines, particularly those focused on stress mitigation, is impeded by the limited understanding of the crocodilian stress response. Fifteen grower Nile crocodiles were subjected to simulated acute transport stress, with blood samples collected at various intervals post-stress. Plasma levels of corticosterone (CORT), dehydroepiandrosterone (DHEA), adrenaline, and noradrenaline were determined using high-performance liquid chromatography. Glucose and lactate were measured using portable meters and the heterophil-to-lymphocyte ratio (HLR) was determined via differential leucocyte counts. Significant differences were elicited after the stressor, with acute fluctuations observed in the fast-acting catecholamines (adrenaline and noradrenaline) when compared to the baseline. Downstream effects of these catecholamines and CORT appear to be associated with a persistent increase in plasma glucose and HLR. Lactate also showed acute fluctuations over time but returned to the baseline by the final measurement. DHEA, which is used in a ratio with CORT, showed fluctuations over time with an inverted release pattern to the catecholamines. The study highlights the temporal dynamics of physiological markers under acute stress, contributing to our understanding of crocodilian stress and potentially informing improved farming practices for conservation and sustainable management.
- Published
- 2024
- Full Text
- View/download PDF
10. Late onset toxicities associated with the use of CDK 4/6 inhibitors in hormone receptor positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) metastatic breast cancer patients: a multidisciplinary, pan-EU position paper regarding their optimal management. The GIOCONDA project
- Author
-
Marina Elena Cazzaniga, Antonio Ciaccio, Romano Danesi, Francois P. Duhoux, Corrado Girmenia, Kalhil Zaman, Henrik Lindman, Fabrizio Luppi, Dimitrios Mavroudis, Ida Paris, Ayodele Olubukola, Ahmed Samreen, Christian Schem, Christian Singer, and Anton Snegovoy
- Subjects
CDK 4/6 inhibitors ,abemaciclib ,ribociclib ,palbociclib ,diarrhea ,liver toxicity and injury ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The personalization of therapies in breast cancer has favoured the introduction of new molecular-targeted therapies into clinical practice. Among them, cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors have acquired increasing importance, with the approval in recent years of palbociclib, ribociclib, and abemaciclib in combination with endocrine therapy. Currently, no guidelines are available to monitor and manage potential long-term toxicities associated with the use of these drugs. A multidisciplinary panel of European oncologists, was supported by a pharmacologist, a hematologist, a hepatologist and a pulmonologist to discuss the management of long-term toxicities, based on the literature review and their clinical experience. The panel provided detailed roadmaps to manage long-term toxicities associated with the use of CDK4/6 inhibitors in clinical practice. Knowing the frequency and characteristics of the toxicity profile associated with each CDK4/6 inhibitor is important in the decision-making process to match the right drug to the right patient.
- Published
- 2023
- Full Text
- View/download PDF
11. Proposing principles towards responsible waste management in South African protected areas
- Author
-
Claudine Roos, Reece C. Alberts, Francois P. Retief, Dirk P. Cilliers, and Alan J. Bond
- Subjects
principles ,responsible waste management ,protected areas ,pollution prevention ,waste management hierarchy ,waste services ,mitigation hierarchy ,knowledge sharing ,partnerships ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
This article synthesises principles towards achieving responsible waste management in South African protected areas. These principles are distilled from and based on existing legislation, guidelines and best practices applicable to environmental management, waste management and protected areas management. The principles are framed around the South African environmental management principles, and specifically contextualised for waste management in protected areas, based on legislation, guidelines and best practices from the literature. Six key principles are synthesised, which aim to achieve responsible waste management in protected areas through: (1) protection of ecosystems and biodiversity; (2) prevention and remediation of pollution; (3) implementation of the waste management hierarchy; (4) provision of effective waste services and infrastructure; (5) promotion of participation and building of partnerships; and (6) contribution to wellbeing, livelihoods and capacity. These principles provide a first step towards the development of detailed guidance on dealing with waste management in South African protected areas and may have relevance in other countries. Conservation implications: The suggested principles for responsible waste management in protected areas aim to provide strategic direction, coordinate and standardise waste management in protected areas. The ultimate aim of the principles is to reduce the adverse impacts of waste in protected areas and to align waste management practices with South African laws and international best practice.
- Published
- 2023
- Full Text
- View/download PDF
12. Pre-Fermentative Cryogenic Treatments: The Effect on Aroma Compounds and Sensory Properties of Sauvignon Blanc and Chenin Blanc Wine—A Review
- Author
-
Valmary M. van Breda, Francois P. van Jaarsveld, and Jessy van Wyk
- Subjects
varietal thiols ,cryogenic technologies ,sensory analysis ,methoxypyrazines ,Sauvignon blanc ,Chenin blanc ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Low-temperature treatments preceding alcoholic fermentation are becoming increasingly popular and have been used in winemaking as a tool to improve wine colour, aroma, and quality. Additionally, the pre-fermentative treatment of grapes with cryogenic agents protects the grape juice (must) from oxidation by reducing the diffusion of atmospheric oxygen into the liquid phase during the winemaking process. Resultant wines were reported to have enhanced varietal aromas, increased complexity, and higher thiol levels. Indications are that increased contact time between skin and juice improves the extraction of the compounds and/or precursors. Recently, there has been considerable interest in the production of wines with enhanced varietal aromas and improved quality by applying innovative winemaking technologies. This review aims to provide an overview of the aroma and organoleptic quality of Sauvignon blanc and Chenin blanc wines produced from grapes that were subjected to pre-fermentative cryogenic treatments including the impact aroma compounds, i.e., volatile thiols and methoxypyrazines.
- Published
- 2024
- Full Text
- View/download PDF
13. Bilayer orthogonal ferromagnetism in CrTe$_2$-based van der Waals system
- Author
-
Bigi, Chiara, Jego, Cyriack, Polewczyk, Vincent, De Vita, Alessandro, Jaouen, Thomas, Tchouekem, Hulerich C., Bertran, François, Fèvre, Patrick Le, Turban, Pascal, Jacquot, Jean-François, Miwa, Jill A., Clark, Oliver J., Jana, Anupam, Chaluvadi, Sandeep Kumar, Orgiani, Pasquale, Cuoco, Mario, Leandersson, Mats, Balasubramanian, Thiagarajan, Olsen, Thomas, Hwang, Younghun, Jamet, Matthieu, and Mazzola, Federico
- Subjects
Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Materials Science - Abstract
Systems with pronounced spin anisotropy play a pivotal role in advancing magnetization switching and spin-wave generation mechanisms, which are fundamental for spintronic technologies. Quasi-van der Waals ferromagnets, particularly Cr$_{1+\delta}$Te$_2$ compounds, represent seminal materials in this field, renowned for their delicate balance between frustrated layered geometries and magnetism. Despite extensive investigation, the precise nature of their magnetic ground state, typically described as a canted ferromagnet, remains contested, as does the mechanism governing spin reorientation under external magnetic fields and varying temperatures. In this work, we leverage a multimodal approach, integrating complementary techniques, to reveal that Cr$_{1+\delta}$Te$_2$ ($\delta = 0.25 - 0.50$) hosts a previously overlooked magnetic phase, which we term orthogonal-ferromagnetism. This single phase consists of alternating atomically sharp single layers of in-plane and out-of-plane ferromagnetic blocks, coupled via exchange interactions and as such, it differs significantly from crossed magnetism, which can be achieved exclusively by stacking multiple heterostructural elements together. Contrary to earlier reports suggesting a gradual spin reorientation in CrTe$_2$-based systems, we present definitive evidence of abrupt spin-flop-like transitions. This discovery, likely due to the improved crystallinity and lower defect density in our samples, repositions Cr$_{1+\delta}$Te$_2$ compounds as promising candidates for spintronic and orbitronic applications, opening new pathways for device engineering.
- Published
- 2024
14. Characterization and performance of the Apollon main short-pulse laser beam following its commissioning at 2 PW level
- Author
-
Yao, Weipeng, Lelièvre, Ronan, Cohen, Itamar, Waltenspiel, Tessa, Allaoua, Amokrane, Antici, Patrizio, Ayoul, Yohan, Beck, Arie, Beluze, Audrey, Blancard, Christophe, Cavanna, Daniel, Chabanis, Mélanie, Chen, Sophia N., Cohen, Erez, Ducasse, Quentin, Dumergue, Mathieu, Hai, Fouad El, Evrard, Christophe, Filippov, Evgeny, Freneaux, Antoine, Gautier, Donald Cort, Gobert, Fabrice, Goupille, Franck, Grech, Michael, Gremillet, Laurent, Heller, Yoav, d'Humières, Emmanuel, Lahmar, Hanna, Lancia, Livia, Lebas, Nathalie, Lecherbourg, Ludovic, Marchand, Stéphane, Mataja, Damien, Meyniel, Gabriel, Michaeli, David, Papadopoulos, Dimitris, Perez, Frédéric, Pikuz, Sergy, Pomerantz, Ishay, Renaudin, Patrick, Romagnani, Lorenzo, Trompier, François, Veuillot, Edouard, Vinchon, Thibaut, Mathieu, François, and Fuchs, Julien
- Subjects
Physics - Plasma Physics - Abstract
We present the results of the second commissioning phase of the short-focal-length area of the Apollon laser facility (located in Saclay, France), which was performed with the main laser beam (F1), scaled to a peak power of 2 PetaWatt. Under the conditions that were tested, this beam delivered on-target pulses of maximum energy up to 45 J and 22 fs duration. Several diagnostics were fielded to assess the performance of the facility. The on-target focal spot and its spatial stability, as well as the secondary sources produced when irradiating solid targets, have all been characterized, with the goal of helping users design future experiments. The laser-target interaction was characterized, as well as emissions of energetic ions, X-ray and neutrons recorded, all showing good laser-to-target coupling efficiency. Moreover, we demonstrated the simultaneous fielding of F1 with the auxiliary 0.5 PW F2 beam of Apollon, enabling dual beam operation. The present commissioning will be followed in 2025 by a further commissioning stage of F1 at the 8 PW level, en route to the final 10 PW goal.
- Published
- 2024
15. Beyond Legal Compliance: The Environmental Performance of Luxury Safari Lodges
- Author
-
Reece C. Alberts, Francois P. Retief, Claudine Roos, Dirk P Cilliers, Jurie Moolman, Justin Bowers, Shaun MacGregor, Felicity Hennman-Weir, and Iain Olivier
- Subjects
luxury safari lodges ,legal compliance ,environmental performance ,best practice ,Hospitality industry. Hotels, clubs, restaurants, etc. Food service ,TX901-946.5 ,Business ,HF5001-6182 - Abstract
The aim of this paper is to evaluate the environmental performance of luxury safari lodges along a performance pathway from legal compliance to best practice. The research results provide a conceptual framework and performance baseline against which lodges can then develop strategies to improve environmental performance. We achieve this aim by adapting the sustainability journey conceptual framework of Willard (2005), that describes five phases of progression along a business performance pathway, from legal compliance to best practice. Performance areas and indicators are developed against the adapted framework covering water, waste, energy and infrastructure development, applied to 12 luxury safari lodges within the South African context. The results show that poor performance was recorded for water management, whilst energy management fared slightly better. Overall performance in relation to waste and infrastructure development fared the best.
- Published
- 2022
- Full Text
- View/download PDF
16. Author Correction: Paclitaxel plus carboplatin and durvalumab with or without oleclumab for women with previously untreated locally advanced or metastatic triple-negative breast cancer: the randomized SYNERGY phase I/II trial
- Author
-
Laurence Buisseret, Delphine Loirat, Philippe Aftimos, Christian Maurer, Kevin Punie, Véronique Debien, Paulus Kristanto, Daniel Eiger, Anthony Goncalves, François Ghiringhelli, Donatienne Taylor, Florent Clatot, Tom Van den Mooter, Jean-Marc Ferrero, Hervé Bonnefoi, Jean-Luc Canon, Francois P. Duhoux, Laura Mansi, Renaud Poncin, Philippe Barthélémy, Nicolas Isambert, Zoë Denis, Xavier Catteau, Roberto Salgado, Elisa Agostinetto, Evandro de Azambuja, Françoise Rothé, Ligia Craciun, David Venet, Emanuela Romano, John Stagg, Marianne Paesmans, Denis Larsimont, Christos Sotiriou, Michail Ignatiadis, and Martine Piccart-Gebhart
- Subjects
Science - Published
- 2023
- Full Text
- View/download PDF
17. BRCA1 Mutation: An Insidious Enemy with Multiple Facets…
- Author
-
Pierrick Godin, Francois P. Duhoux, Filomena Mazzeo, Michel Rojas, Emmanuel Bollue, Aline François, Christine Galant, Julien Coulie, Maude Coyette, Audrey Lentini, Yannick Deswisen, Vasiliki Perlepe, Latifa Fellah, Isabelle Leconte, and Martine Berlière
- Subjects
hereditary breast and ovarian cancer ,angiosarcoma ,parp inhibitors ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Epidemiological studies suggest that around 10% of breast cancers are due to hereditary predisposition. The risk of cancer is exponentially increased in patients harboring BRCA1 or BRCA2 mutations. Cumulative breast cancer risk by age 80 is estimated to 72% for BRCA1 mutation carriers and 69% for BRCA2. The cumulative risk estimates for developing ovarian cancer by age 80 are 44% for BRCA1 mutation carriers and 17% for BRCA2. We present here the case of a 59-year-old woman who developed a left breast cancer in 2014 treated by conservative surgery, radiotherapy, and endocrine therapy with letrozole. The diagnosis of BRCA1 mutation was performed in 2015. In 2018, the patient was referred to our institution for treatment of an aggressive angiosarcoma developed in the same breast. She had undergone radical hysterectomy by the age of 49 years for a benign uterine pathology. In 2020, she developed a tumor in the gastric wall; histological analysis confirmed a serous papillary carcinoma of ovarian origin. She was treated – after gastrectomy and lymphadenectomy – with 6 courses of carboplatin and paclitaxel followed by olaparib therapy. In 2021, she suffered from a chest recurrence of high grade angiosarcoma. New resection with free margins was performed. We discuss the link between angiosarcomas and BRCA mutations, the therapeutic options for angiosarcoma and ovarian cancer of extra ovarian origin and the follow-up modalities.
- Published
- 2022
- Full Text
- View/download PDF
18. Neural ensemble dynamics in trunk and hindlimb sensorimotor cortex encode for the control of postural stability
- Author
-
Gregory D. Disse, Bharadwaj Nandakumar, Francois P. Pauzin, Gary H. Blumenthal, Zhaodan Kong, Jochen Ditterich, and Karen A. Moxon
- Subjects
CP: Neuroscience ,Biology (General) ,QH301-705.5 - Abstract
Summary: The cortex has a disputed role in monitoring postural equilibrium and intervening in cases of major postural disturbances. Here, we investigate the patterns of neural activity in the cortex that underlie neural dynamics during unexpected perturbations. In both the primary sensory (S1) and motor (M1) cortices of the rat, unique neuronal classes differentially covary their responses to distinguish different characteristics of applied postural perturbations; however, there is substantial information gain in M1, demonstrating a role for higher-order computations in motor control. A dynamical systems model of M1 activity and forces generated by the limbs reveals that these neuronal classes contribute to a low-dimensional manifold comprised of separate subspaces enabled by congruent and incongruent neural firing patterns that define different computations depending on the postural responses. These results inform how the cortex engages in postural control, directing work aiming to understand postural instability after neurological disease.
- Published
- 2023
- Full Text
- View/download PDF
19. Editorial: Dynamics and impacts of tropical climate variability: Understanding trends and future projections
- Author
-
Agus Santoso, Andrea S. Taschetto, Shayne McGregor, Mathew Koll Roxy, Christine Chung, Bo Wu, and Francois P. Delage
- Subjects
El Niño Southern Oscillation (ENSO) ,Indian Ocean Dipole (IOD) ,climate models ,ENSO teleconnection ,equatorial Pacific currents ,South Pacific Meridional Mode ,Environmental sciences ,GE1-350 - Published
- 2023
- Full Text
- View/download PDF
20. Channel deformations during elastocapillary spreading of gaseous embolisms in biomimetic leaves
- Author
-
Gauci, François-Xavier, Jami, Ludovic, Keiser, Ludovic, Cohen, Céline, and Noblin, Xavier
- Subjects
Physics - Fluid Dynamics ,Physics - Biological Physics - Abstract
The nucleation and/or spreading of bubbles in water under tension (due to water evaporation) can be problematic for most plants along the ascending sap network from root to leaves, named xylem. Due to global warming, trees facing drought conditions are particularly threatened by the formation of such air embolisms, which spreads intermittently and hinder the flow of sap and could ultimately result in their demise. PDMS-based biomimetic leaves simulating evapotranspiration have demonstrated that, in a linear configuration, the existence of a slender constriction in the channel allows for the creation of intermittent embolism propagation (as an interaction between the elasticity of the biomimetic leaf (mainly the deformable ceiling of the microchannels) and the capillary forces at the air/water interfaces) \cite{Keiser2022}-\cite{keiser2024}. Here we use analog PDMS-based biomimetic leaves in 1d and 2d. To better explore the embolism spreading mechanism, we add to the setup an additional technique, allowing to measure directly the microchannel's ceiling deformation versus time, which corresponds to the pressure variations. We present here such a method that allows to have quantitative insights in the dynamics of embolism spreading. The coupling between channel deformations and the Laplace pressure threshold explains the observed elastocapillary dynamics.
- Published
- 2025
21. Recurrent Features of Amplitudes in Planar $\mathcal{N}=4$ Super Yang-Mills Theory
- Author
-
Cai, Tianji, Charton, François, Cranmer, Kyle, Dixon, Lance J., Merz, Garrett W., and Wilhelm, Matthias
- Subjects
High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
The planar three-gluon form factor for the chiral stress tensor operator in planar maximally supersymmetric Yang-Mills theory is an analog of the Higgs-to-three-gluon scattering amplitude in QCD. The amplitude (symbol) bootstrap program has provided a wealth of high-loop perturbative data about this form factor, with results up to eight loops available. The symbol of the form factor at $L$ loops is given by words of length $2L$ in six letters with associated integer coefficients. In this paper, we analyze this data, describing patterns of zero coefficients and relations between coefficients. We find many sequences of words whose coefficients are given by closed-form expressions which we expect to be valid at any loop order. Moreover, motivated by our previous machine-learning analysis, we identify simple recursion relations that relate the coefficient of a word to the coefficients of particular lower-loop words. These results open an exciting door for understanding scattering amplitudes at all loop orders., Comment: 28 pages, 1 figure, 5 tables
- Published
- 2025
22. Automatizing the search for mass resonances using BumpNet
- Author
-
Arguin, Jean-Francois, Azuelos, Georges, Baril, Émile, Bessudo, Ilan, Bilodeau, Fannie, Borysova, Maryna, Bressler, Shikma, Calvet, Samuel, Donini, Julien, Dreyer, Etienne, Chu, Michael Kwok Lam, Mayer, Eva, Meszaros, Ethan, Kakati, Nilotpal, Dias, Bruna Pascual, Potdevin, Joséphine, Shkuri, Amit, and Usman, Muhammad
- Subjects
Physics - Data Analysis, Statistics and Probability ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
The search for resonant mass bumps in invariant-mass distributions remains a cornerstone strategy for uncovering Beyond the Standard Model (BSM) physics at the Large Hadron Collider (LHC). Traditional methods often rely on predefined functional forms and exhaustive computational and human resources, limiting the scope of tested final states and selections. This work presents BumpNet, a machine learning-based approach leveraging advanced neural network architectures to generalize and enhance the Data-Directed Paradigm (DDP) for resonance searches. Trained on a diverse dataset of smoothly-falling analytical functions and realistic simulated data, BumpNet efficiently predicts statistical significance distributions across varying histogram configurations, including those derived from LHC-like conditions. The network's performance is validated against idealized likelihood ratio-based tests, showing minimal bias and strong sensitivity in detecting mass bumps across a range of scenarios. Additionally, BumpNet's application to realistic BSM scenarios highlights its capability to identify subtle signals while managing the look-elsewhere effect. These results underscore BumpNet's potential to expand the reach of resonance searches, paving the way for more comprehensive explorations of LHC data in future analyses.
- Published
- 2025
23. Tomographic identification of all molecular orbitals in a wide binding energy range
- Author
-
Haags, Anja, Brandstetter, Dominik, Yang, Xiaosheng, Egger, Larissa, Kirschner, Hans, Gottwald, Alexander, Richter, Mathias, Koller, Georg, Bocquet, François C., Wagner, Christian, Ramsey, Michael G., Soubatch, Serguei, Puschnig, Peter, and Tautz, F. Stefan
- Subjects
Physics - Chemical Physics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
In the past decade, photoemission orbital tomography (POT) has evolved into a powerful tool to investigate the electronic structure of organic molecules adsorbed on surfaces. Here we show that POT allows for the comprehensive experimental identification of all molecular orbitals in a substantial binding energy range, in the present case more than 10 eV. Making use of the angular distribution of photoelectrons as a function of binding energy, we exemplify this by extracting orbital-resolved partial densities of states (pDOS) for 15 $\pi$ and 23 $\sigma$ orbitals from the experimental photoemission intensities of the prototypical organic molecule bisanthene (C$_{28}$H$_{14}$) on a Cu(110) surface. In their entirety, these experimentally measured orbital-resolved pDOS for an essentially complete set of orbitals serve as a stringent benchmark for electronic structure methods, which we illustrate by performing density functional theory (DFT) calculations employing four frequently-used exchange-correlation functionals. By computing the respective molecular-orbital-projected densities of states of the bisanthene/Cu(110) interface, a one-to-one comparison with experimental data for an unprecedented number of 38 orbital energies becomes possible. The quantitative analysis of our data reveals that the range-separated hybrid functional HSE performs best for the investigated organic/metal interface. At a more fundamental level, the remarkable agreement between the experimental and the Kohn-Sham orbital energies over a binding energy range larger than 10\,eV suggests that -- perhaps unexpectedly -- Kohn-Sham orbitals approximate Dyson orbitals, which would rigorously account for the electron extraction process in photoemission spectroscopy but are notoriously difficult to compute, in a much better way than previously thought., Comment: arXiv admin note: text overlap with arXiv:2209.11516
- Published
- 2025
24. From Mesh Completion to AI Designed Crown
- Author
-
Hosseinimanesh, Golriz, Ghadiri, Farnoosh, Guibault, Francois, Cheriet, Farida, and Keren, Julia
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Designing a dental crown is a time-consuming and labor intensive process. Our goal is to simplify crown design and minimize the tediousness of making manual adjustments while still ensuring the highest level of accuracy and consistency. To this end, we present a new end- to-end deep learning approach, coined Dental Mesh Completion (DMC), to generate a crown mesh conditioned on a point cloud context. The dental context includes the tooth prepared to receive a crown and its surroundings, namely the two adjacent teeth and the three closest teeth in the opposing jaw. We formulate crown generation in terms of completing this point cloud context. A feature extractor first converts the input point cloud into a set of feature vectors that represent local regions in the point cloud. The set of feature vectors is then fed into a transformer to predict a new set of feature vectors for the missing region (crown). Subsequently, a point reconstruction head, followed by a multi-layer perceptron, is used to predict a dense set of points with normals. Finally, a differentiable point-to-mesh layer serves to reconstruct the crown surface mesh. We compare our DMC method to a graph-based convolutional neural network which learns to deform a crown mesh from a generic crown shape to the target geometry. Extensive experiments on our dataset demonstrate the effectiveness of our method, which attains an average of 0.062 Chamfer Distance.The code is available at:https://github.com/Golriz-code/DMC.gi
- Published
- 2025
25. Realizing Lattice Surgery on Two Distance-Three Repetition Codes with Superconducting Qubits
- Author
-
Besedin, Ilya, Kerschbaum, Michael, Knoll, Jonathan, Hesner, Ian, Bödeker, Lukas, Colmenarez, Luis, Hofele, Luca, Lacroix, Nathan, Hellings, Christoph, Swiadek, François, Flasby, Alexander, Panah, Mohsen Bahrami, Zanuz, Dante Colao, Müller, Markus, and Wallraff, Andreas
- Subjects
Quantum Physics - Abstract
Quantum error correction is needed for quantum computers to be capable of fault-tolerantly executing algorithms using hundreds of logical qubits. Recent experiments have demonstrated subthreshold error rates for state preservation of a single logical qubit. In addition, the realization of universal quantum computation requires the implementation of logical entangling gates. Lattice surgery offers a practical approach for implementing such gates, particularly in planar quantum processor layouts. In this work, we demonstrate lattice surgery between two distance-three repetition-code qubits by splitting a single distance-three surface-code qubit. Using a quantum circuit fault-tolerant to bit-flip errors, we achieve an improvement in the value of the decoded $ZZ$ logical two-qubit observable compared to a similar non-encoded circuit. By preparing the surface-code qubit in initial states parametrized by a varying polar angle, we evaluate the performance of the lattice surgery operation for non-cardinal states on the logical Bloch sphere and employ logical two-qubit tomography to reconstruct the Pauli transfer matrix of the operation. In this way, we demonstrate the functional building blocks needed for lattice surgery operations on larger-distance codes based on superconducting circuits., Comment: 19 pages, 13 figures
- Published
- 2025
26. NGTS-EB-7, an eccentric, long-period, low-mass eclipsing binary
- Author
-
Rodel, Toby, Watson, Christopher. A., Ulmer-Moll, Solène, Gill, Samuel, Maxted, Pierre F. L., Casewell, Sarah L., Brahm, Rafael, Wilson, Thomas G, Costes, Jean C., Eschen, Yoshi Nike Emilia, Doyle, Lauren, Freckelton, Alix V., Alves, Douglas R., Apergis, Ioannis, Bayliss, Daniel, Bouchy, Francois, Burleigh, Matthew R., Dumusque, Xavier, Eberhardt, Jan, Fernández, Jorge Fernández, Gillen, Edward, Goad, Michael R., Hawthorn, Faith, Helled, Ravit, Henning, Thomas, Hobbs, Katlyn L., Jenkins, James S., Jordán, Andrés, Kendall, Alicia, Lendl, Monika, McCormac, James, de Mooij, Ernst J. W., O'Brien, Sean M., Saha, Suman, Pinto, Marcelo Tala, Trifonov, Trifon, Udry, Stéphane, and Wheatley, Peter J.
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Despite being the most common types of stars in the Galaxy, the physical properties of late M dwarfs are often poorly constrained. A trend of radius inflation compared to evolutionary models has been observed for earlier type M dwarfs in eclipsing binaries, possibly caused by magnetic activity. It is currently unclear whether this trend also extends to later type M dwarfs below the convective boundary. This makes the discovery of lower-mass, fully convective, M dwarfs in eclipsing binaries valuable for testing evolutionary models especially in longer-period binaries where tidal interaction between the primary and secondary is negligible. With this context, we present the discovery of the NGTS-EB-7 AB system, an eclipsing binary containing a late M dwarf secondary and an evolved G-type primary star. The secondary star has a radius of $0.125 \pm 0.006 R_\odot$ , a mass of $0.096 \pm 0.004 M_\odot$ and follows a highly eccentric $(e=0.71436 \pm 0.00085)$ orbit every $193.35875 \pm 0.00034$ days. This makes NGTS-EB-7 AB the third longest-period eclipsing binary system with a secondary smaller than $200 M_J$ with the mass and radius constrained to better than $5 \%$. In addition, NGTS-EB-7 is situated near the centre of the proposed LOPS2 southern field of the upcoming PLATO mission, allowing for detection of the secondary eclipse and measurement of the companion`s temperature. With its long-period and well-constrained physical properties - NGTS-EB-7 B will make a valuable addition to the sample of M dwarfs in eclipsing binaries and help in determining accurate empirical mass/radius relations for later M dwarf stars., Comment: Main body: 14 pages, 6 figures, 5 tables. Appendices: 7 pages, 5 figures, 5 tables
- Published
- 2025
- Full Text
- View/download PDF
27. BabyLMs for isiXhosa: Data-Efficient Language Modelling in a Low-Resource Context
- Author
-
Matzopoulos, Alexis, Hendriks, Charl, Mahomed, Hishaam, and Meyer, Francois
- Subjects
Computer Science - Computation and Language - Abstract
The BabyLM challenge called on participants to develop sample-efficient language models. Submissions were pretrained on a fixed English corpus, limited to the amount of words children are exposed to in development (<100m). The challenge produced new architectures for data-efficient language modelling, which outperformed models trained on trillions of words. This is promising for low-resource languages, where available corpora are limited to much less than 100m words. In this paper, we explore the potential of BabyLMs for low-resource languages, using the isiXhosa language as a case study. We pretrain two BabyLM architectures, ELC-BERT and MLSM, on an isiXhosa corpus. They outperform a vanilla pretrained model on POS tagging and NER, achieving notable gains (+3.2 F1) for the latter. In some instances, the BabyLMs even outperform XLM-R. Our findings show that data-efficient models are viable for low-resource languages, but highlight the continued importance, and lack of, high-quality pretraining data. Finally, we visually analyse how BabyLM architectures encode isiXhosa.
- Published
- 2025
28. MVP: Multimodal Emotion Recognition based on Video and Physiological Signals
- Author
-
Strizhkova, Valeriya, Kachmar, Hadi, Chaptoukaev, Hava, Kalandadze, Raphael, Kukhilava, Natia, Tsmindashvili, Tatia, Abo-Alzahab, Nibras, Zuluaga, Maria A., Balazia, Michal, Dantcheva, Antitza, Brémond, François, and Ferrari, Laura
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,68T05, 68T10 ,I.5 - Abstract
Human emotions entail a complex set of behavioral, physiological and cognitive changes. Current state-of-the-art models fuse the behavioral and physiological components using classic machine learning, rather than recent deep learning techniques. We propose to fill this gap, designing the Multimodal for Video and Physio (MVP) architecture, streamlined to fuse video and physiological signals. Differently then others approaches, MVP exploits the benefits of attention to enable the use of long input sequences (1-2 minutes). We have studied video and physiological backbones for inputting long sequences and evaluated our method with respect to the state-of-the-art. Our results show that MVP outperforms former methods for emotion recognition based on facial videos, EDA, and ECG/PPG., Comment: Preprint. Final paper accepted at Affective Behavior Analysis in-the-Wild (ABAW) at IEEE/CVF European Conference on Computer Vision (ECCV), Milan, September, 2024. 17 pages
- Published
- 2025
29. Solving the Porous Medium Equation with the eXtreme Mesh deformation approach (X-Mesh)
- Author
-
Chemin, Alexandre, Lambrechts, Jonathan, Moës, Nicolas, and Remacle, Jean-François
- Subjects
Mathematics - Numerical Analysis - Abstract
We introduce a new scheme for solving the non-regularized Porous Medium Equation. It is mass conserving and uses only positive unknown values. To address these typically conflicting features, we employ the eXtreme Mesh deformation approach (X-Mesh), specifically designed for problems involving sharp interfaces. The method ensures that the interface is always meshed, even in the face of complex topological changes, without the need for remeshing or altering the mesh topology. We illustrate the effectiveness of the approach through various numerical experiments.
- Published
- 2025
30. Classifier Weighted Mixture models
- Author
-
Argouarc'h, Elouan, Desbouvries, François, Barat, Eric, Kawasaki, Eiji, and Dautremer, Thomas
- Subjects
Statistics - Machine Learning ,Computer Science - Machine Learning - Abstract
This paper proposes an extension of standard mixture stochastic models, by replacing the constant mixture weights with functional weights defined using a classifier. Classifier Weighted Mixtures enable straightforward density evaluation, explicit sampling, and enhanced expressivity in variational estimation problems, without increasing the number of components nor the complexity of the mixture components.
- Published
- 2025
31. A Coupled PFEM-DEM Model for Fluid-Granular Flows with Free-Surface Dynamics Applied to Landslides
- Author
-
Leyssens, Thomas, Henry, Michel, Lambrechts, Jonathan, Legat, Vincent, and Remacle, Jean-François
- Subjects
Computer Science - Computational Engineering, Finance, and Science - Abstract
Free surface and granular fluid mechanics problems combine the challenges of fluid dynamics with aspects of granular behaviour. This type of problem is particularly relevant in contexts such as the flow of sediments in rivers, the movement of granular soils in reservoirs, or the interactions between a fluid and granular materials in industrial processes such as silos. The numerical simulation of these phenomena is challenging because the solution depends not only on the multiple phases that strongly interact with each other, but also on the need to describe the geometric evolution of the different interfaces. This paper presents an approach to the simulation of fluid-granular phenomena involving strongly deforming free surfaces. The Discrete Element Method (DEM) is combined with the Particle Finite Element Method (PFEM) and the fluid-grain interface is treated by a two-way coupling between the two phases. The fluid-air interface is solved by a free surface model. The geometric and topological variations are therefore naturally provided by the full Lagrangian description of all phases. The approach is validated on benchmark test cases such as two-phase dam failures and then applied to a real landslide problem.
- Published
- 2025
32. CM3T: Framework for Efficient Multimodal Learning for Inhomogeneous Interaction Datasets
- Author
-
Agrawal, Tanay, Guermal, Mohammed, Balazia, Michal, and Bremond, Francois
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,68T05, 68T10 ,I.5 - Abstract
Challenges in cross-learning involve inhomogeneous or even inadequate amount of training data and lack of resources for retraining large pretrained models. Inspired by transfer learning techniques in NLP, adapters and prefix tuning, this paper presents a new model-agnostic plugin architecture for cross-learning, called CM3T, that adapts transformer-based models to new or missing information. We introduce two adapter blocks: multi-head vision adapters for transfer learning and cross-attention adapters for multimodal learning. Training becomes substantially efficient as the backbone and other plugins do not need to be finetuned along with these additions. Comparative and ablation studies on three datasets Epic-Kitchens-100, MPIIGroupInteraction and UDIVA v0.5 show efficacy of this framework on different recording settings and tasks. With only 12.8% trainable parameters compared to the backbone to process video input and only 22.3% trainable parameters for two additional modalities, we achieve comparable and even better results than the state-of-the-art. CM3T has no specific requirements for training or pretraining and is a step towards bridging the gap between a general model and specific practical applications of video classification., Comment: Preprint. Final paper accepted at the IEEE/CVF Winter Conference on Applications of Computer Vision (WACV), Tucson, February, 2025. 10 pages
- Published
- 2025
33. powerROC: An Interactive Web Tool for Sample Size Calculation in Assessing Models' Discriminative Abilities
- Author
-
Grolleau, François, Tibshirani, Robert, and Chen, Jonathan H.
- Subjects
Statistics - Methodology - Abstract
Rigorous external validation is crucial for assessing the generalizability of prediction models, particularly by evaluating their discrimination (AUROC) on new data. This often involves comparing a new model's AUROC to that of an established reference model. However, many studies rely on arbitrary rules of thumb for sample size calculations, often resulting in underpowered analyses and unreliable conclusions. This paper reviews crucial concepts for accurate sample size determination in AUROC-based external validation studies, making the theory and practice more accessible to researchers and clinicians. We introduce powerROC, an open-source web tool designed to simplify these calculations, enabling both the evaluation of a single model and the comparison of two models. The tool offers guidance on selecting target precision levels and employs flexible approaches, leveraging either pilot data or user-defined probability distributions. We illustrate powerROC's utility through a case study on hospital mortality prediction using the MIMIC database.
- Published
- 2025
34. Major-minor mean field games: common noise helps
- Author
-
Delarue, Francois and Mou, Chenchen
- Subjects
Mathematics - Optimization and Control ,Mathematics - Probability ,Primary: 49N80, 91A16, Secondary: 35R60, 60H10, 60H15 - Abstract
The objective of this work is to study the existence, uniqueness, and stability of equilibria in mean field games involving a major player and a continuum of minor players over finite intervals of arbitrary length. Following earlier articles addressing similar questions in the context of classical mean field games, the cost functions for the minor players are assumed to satisfy the Lasry-Lions monotonicity condition. In this contribution, we demonstrate that if, in addition to the monotonicity condition, the intensity of the (Brownian) noise driving the major player is sufficiently high, then -- under further mild regularity assumptions on the coefficients -- existence, uniqueness, and stability of equilibria are guaranteed. A key challenge is to show that the threshold (beyond which the noise intensity must be taken) can be chosen independently of the length of the time interval over which the game is defined. Building on the stability properties thus established, we further show that the associated system of master equations admits a unique classical solution. To the best of our knowledge, this is the first result of its kind for major-minor mean field games defined over intervals of arbitrary length.
- Published
- 2025
35. Identifying Surgical Instruments in Pedagogical Cataract Surgery Videos through an Optimized Aggregation Network
- Author
-
Sinha, Sanya, Balazia, Michal, and Bremond, Francois
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,68T05, 68T10 ,I.5 - Abstract
Instructional cataract surgery videos are crucial for ophthalmologists and trainees to observe surgical details repeatedly. This paper presents a deep learning model for real-time identification of surgical instruments in these videos, using a custom dataset scraped from open-access sources. Inspired by the architecture of YOLOV9, the model employs a Programmable Gradient Information (PGI) mechanism and a novel Generally-Optimized Efficient Layer Aggregation Network (Go-ELAN) to address the information bottleneck problem, enhancing Minimum Average Precision (mAP) at higher Non-Maximum Suppression Intersection over Union (NMS IoU) scores. The Go-ELAN YOLOV9 model, evaluated against YOLO v5, v7, v8, v9 vanilla, Laptool and DETR, achieves a superior mAP of 73.74 at IoU 0.5 on a dataset of 615 images with 10 instrument classes, demonstrating the effectiveness of the proposed model., Comment: Preprint. Full paper accepted at the IEEE International Conference on Image Processing Applications and Systems (IPAS), Lyon, France, Jan 2025. 6 pages
- Published
- 2025
36. Relational bundle geometric formulation of non-relativistic quantum mechanics
- Author
-
François, J. and Ravera, L.
- Subjects
Quantum Physics ,High Energy Physics - Theory ,Mathematical Physics - Abstract
We present a bundle geometric formulation of non-relativistic many-particles Quantum Mechanics. A wave function is seen to be a $\mathbb{C}$-valued cocyclic tensorial 0-form on configuration space-time seen as a principal bundle, while the Schr\"odinger equation flows from its covariant derivative, with the action functional supplying a (flat) cocyclic connection 1-form on the configuration bundle. In line with the historical motivations of Dirac and Feynman, ours is thus a Lagrangian geometric formulation of QM, in which the Dirac-Feynman path integral arises in a geometrically natural way. Applying the dressing field method, we obtain a relational reformulation of this geometric non-relativistic QM: a relational wave function is realised as a basic cocyclic 0-form on the configuration bundle. In this relational QM, any particle position can be used as a dressing field, i.e. as a "physical reference frame". The dressing field method naturally accounts for the freedom in choosing the dressing field, which is readily understood as a covariance of the relational formulation under changes of physical reference frame., Comment: 34 pages, 2 figures
- Published
- 2025
37. Asymptotics for the magnetic Dirichlet-to-Neumann eigenvalues in general domains
- Author
-
Helffer, Bernard, Kachmar, Ayman, and Nicoleau, Francois
- Subjects
Mathematical Physics ,Mathematics - Analysis of PDEs ,Mathematics - Spectral Theory ,Primary 58J50, Secondary 35P20 - Abstract
Inspired by a paper by T. Chakradhar, K. Gittins, G. Habib and N. Peyerimhoff, we analyze their conjecture that the ground state energy of the magnetic Dirichlet-to-Neumann operator tends to infinity as the magnetic field tends to infinity. More precisely, we prove refined conjectures for general two dimensional domains, based on the analysis in the case of the half-plane and the disk by two of us (B.H. and F.N.). We also extend our analysis to the three dimensional case, and explore a connection with the eigenvalue asymptotics of the magnetic Robin Laplacian., Comment: 34 pages
- Published
- 2025
38. An intriguing coincidence between the majority of vast polar structure dwarfs and a recent major merger at the M31 position
- Author
-
Akib, Istiak, Hammer, François, Yang, Yanbin, Pawlowski, Marcel S., and Wang, Jianling
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
A significant part of the Milky Way (MW) dwarf galaxies orbit within a Vast POlar Structure (VPOS) that is perpendicular to the Galactic disk, whose origin has not yet been identified. It includes the Large Magellanic Cloud (LMC) and its six dynamically associated dwarf galaxies. Andromeda Galaxy (M31) experienced a major merger two to three billion years ago, and its accurate modelling predicts that an associated tidal tail is pointing toward the Galaxy. Here, we have tested a possible association between M31 tidal tail particles and MW dwarf galaxies, focusing first on the LMC and its associated dwarfs since they are less affected by ram pressure. We traced back these dwarf galaxy orbits by one billion years and calculated their association to the tidal tail particles in the 6D phase space, based on their proper motion from Gaia DR3. We find that for low-mass MW models (total mass smaller than 5 $\times 10^{11} M_{\odot}$), the separation in the 6D space can be less than 1$\sigma$ for most of the M31 modelling, while an important degree of freedom is provided by the still unknown proper motion of M31. We further discover that many other dwarfs could also be associated with the M31 tidal tails if their motions had been radially slowed down, as expected from the ram pressure exerted by the MW corona. This intriguing coincidence could explain the origin of the VPOS, which came from a matter exchange between M31 and MW., Comment: A&A, accepted 20th December 2024, 10 pages, 9 figures, and Appendix A, B, C, D & E
- Published
- 2025
39. Rotational excitation cross sections for chloronium based on a new 5D interaction potential with molecular hydrogen
- Author
-
Demes, Sándor, Kędziera, Dariusz, Faure, Alexandre, and Lique, François
- Subjects
Physics - Chemical Physics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Chloronium (H$_2$Cl$^+$) is an important intermediate of Cl-chemistry in space. The accurate knowledge of its collisional properties allows a better interpretation of the corresponding observations in interstellar clouds and therefore a better estimation of its abundance in these environments. While the ro-vibrational spectroscopy of H$_2$Cl$^+$ is well known, the studies of its collisional excitation are rather limited and these are available for the interaction with helium atoms only. We provide a new 5-dimensional rigid-rotor potential energy surface for the interaction of H$_2$Cl$^+$ with H$_2$, calculated from explicitly correlated coupled cluster ab initio theory, which was fitted then with a set of analytical functions, allowing to perform scattering calculations using accurate quantum theories. We analyze the collision-energy-dependence of the rotational state-to-state cross sections and the temperature dependence of the corresponding thermal rate coefficients, with a particular attention on the collisional propensity rules. When comparing our results for collisions with H$_2$ with those obtained with He as a colliding partner, we found very significant differences with non-linear scaling trends, which proves again that He is not a suitable proxy for collisions between hydride molecules and molecular hydrogen, the most abundant gas particle in the interstellar medium., Comment: Accepted in Journal of Physical Chemistry A (December 12, 2024)
- Published
- 2024
- Full Text
- View/download PDF
40. The Pristine survey. XXVI. Chemical abundances of subgiant stars of the extremelymetal-poor stream C-19
- Author
-
Bonifacio, P., Caffau, E., François, P., Martin, N., Ibata, R., Yuan, Z., Kordopatis, G., Hernández, J. I. González, Aguado, D. S., Thomas, G. F., Viswanathan, A., Dodd, E., Gran, F., Starkenburg, E., Lardo, C., Errani, R., Fouesneau, M., Navarro, J. F., Venn, K. A., and Malhan, K.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Context: The C-19 stellar stream is the most metal-poor stream known to date. While its width and velocity dispersion indicate a dwarf galaxy origin, its metallicity spread and abundance patterns are more similar to those of globular clusters (GCs). If it is indeed of GC origin, its extremely low metallicity ([Fe/H]=-3.4, estimated from giant stars) implies that these stellar systems can form out of gas that is as extremely poor in metals as this. Previously, only giant stream stars were observed spectroscopically, although the majority of stream stars are unevolved stars. Aims: We pushed the spectroscopic observations to the subgiant branch stars ($G\approx 20$) in order to consolidate the chemical and dynamical properties of C-19. Methods: We used the high-efficiency spectrograph X-shooter fed by the ESO 8.2 m VLT telescope to observe 15 candidate subgiant C-19 members. The spectra were used to measure radial velocities and to determine chemical abundances using the \mygi\ code. Results; We developed a likelihood model that takes metallicity and radial velocities into account. We conclude that 12 stars are likely members of C-19, while 3 stars (S05, S12, and S13) are likely contaminants. When these 3 stars are excluded, our model implies a mean metallicity $\rm \langle [Fe/H]\rangle = -3.1\pm 0.1$, the mean radial velocity is $\langle v_r\rangle = -192\pm3$ kms$^{-1}$, and the velocity dispersion is $\sigma_{vr} = 5.9^{+3.6}_{-5.9}$ kms$^{-1}$. This all agrees within errors with previous studies. The A(Mg) of a sample of 15 C-19 members, including 6 giant stars, shows a standard deviation of 0.44 dex, and the mean uncertainty on Mg is 0.25 dex. Conclusions: Our preferred interpretation of the current data is that C-19 is a disrupted GC. We cannot completely rule out the possibility that the GC could have belonged to a dwarf galaxy that contained more metal-rich stars, however. This scenario would explain the radial velocity members at higher metallicity, as well as the width and velocity dispersion of the stream. In either case, a GC formed out of gas as poor in metals as these stars seems necessary to explain the existence of C-19. The possibility that no GC was associated with C-19 cannot be ruled out either., Comment: Astronomy & Astrophysics - A&A, In press
- Published
- 2024
- Full Text
- View/download PDF
41. Variational integrators for stochastic Hamiltonian systems on Lie groups: properties and convergence
- Author
-
Gay-Balmaz, François and Wu, Meng
- Subjects
Mathematics - Numerical Analysis ,Mathematics - Dynamical Systems ,Mathematics - Symplectic Geometry - Abstract
We derive variational integrators for stochastic Hamiltonian systems on Lie groups using a discrete version of the stochastic Hamiltonian phase space principle. The structure-preserving properties of the resulting scheme, such as symplecticity, preservation of the Lie-Poisson structure, preservation of the coadjoint orbits, and conservation of Casimir functions, are discussed, along with a discrete Noether theorem for subgroup symmetries. We also consider in detail the case of stochastic Hamiltonian systems with advected quantities, studying the associated structure-preserving properties in relation to semidirect product Lie groups. A full convergence proof for the scheme is provided for the case of the Lie group of rotations. Several numerical examples are presented, including simulations of the free rigid body and the heavy top.
- Published
- 2024
42. Compton photons at the GeV scale from self-aligned collisions with a plasma mirror
- Author
-
Matheron, Aimé, Marquès, Jean-Raphaël, Lelasseux, Vincent, Shou, Yinren, Andriyash, Igor A., Phung, Vanessa Ling Jen, Ayoul, Yohann, Beluze, Audrey, Dăncuş, Ioan, Dorchies, Fabien, D'Souza, Flanish, Dumergue, Mathieu, Frotin, Mickaël, Gautier, Julien, Gobert, Fabrice, Gugiu, Marius, Krishnamurthy, Santhosh, Kargapolov, Ivan, Kroupp, Eyal, Lancia, Livia, Lazăr, Alexandru, Leblanc, Adrien, Lo, Mohamed, Mataja, Damien, Mathieu, François, Papadopoulos, Dimitrios, Claveria, Pablo San Miguel, Phuoc, Kim Ta, Talposi, Anda-Maria, Tata, Sheroy, Ur, Călin A., Ursescu, Daniel, Văsescu, Lidia, Doria, Domenico, Malka, Victor, Ghenuche, Petru, and Corde, Sebastien
- Subjects
Physics - Plasma Physics ,Physics - Accelerator Physics - Abstract
With today's multi-petawatt lasers, testing quantum electrodynamics (QED) in the strong field regime, where the electric field exceeds the Schwinger critical field in the rest frame of an electron, becomes within reach. Inverse Compton scattering of an intense laser pulse off a high-energy electron beam is the mainstream approach, resulting in the emission of high-energy photons that can decay into Breit-Wheeler electron-positron pairs. Here, we demonstrate experimentally that very high energy photons can be generated in a self-aligned single-laser Compton scattering setup, combining a laser-plasma accelerator and a plasma mirror. Reaching up to the GeV scale, photon emission via nonlinear Compton scattering exhibits a nonclassical scaling in the experiment that is consistent with electric fields reaching up to a fraction $\chi\simeq0.3$ of the Schwinger field in the electron rest frame. These foolproof collisions guaranteed by automatic laser-electron overlap provide a new approach for precise investigations of strong-field QED processes.
- Published
- 2024
43. Towards the Automatic Detection of Vection in Virtual Reality Using EEG
- Author
-
Van der Lee, Gaël, Lécuyer, Anatole, Naud, Maxence, Scherer, Reinhold, Cabestaing, François, and Si-Mohammed, Hakim
- Subjects
Computer Science - Human-Computer Interaction ,Quantitative Biology - Neurons and Cognition - Abstract
Vection, the visual illusion of self-motion, provides a strong marker of the VR user experience and plays an important role in both presence and cybersickness. Traditional measurements have been conducted using questionnaires, which exhibit inherent limitations due to their subjective nature and preventing real-time adjustments. Detecting vection in real time would allow VR systems to adapt to users' needs, improving comfort and minimizing negative effects like motion sickness. This paper investigates the presence of vection markers in electroencephalogram (EEG) brain signals using evoked potentials (brain responses to external stimulations). We designed a VR experiment that induces vection using two conditions: (1) forward acceleration or (2) backward acceleration. We recorded both electroencephalographic (EEG) signals and gathered subjective reports on thirty (30) participants. We found an evoked potential of vection characterized by a positive peak around 600 ms (P600) after stimulus onset in the parietal region and a simultaneous negative peak in the frontal region. Our results also found participant variability in sensitivity to vection and cybersickness and EEG markers of acceleration across subjects. This result is promising for potential detection of vection using EEG and paves the way for future studies towards a better understanding of vection. It also provides insights into the functional role of the visual system and its integration with the vestibular system during motion-perception. It has the potential to help enhance VR user experience by qualifying users' perceived vection and adapting the VR environments accordingly.
- Published
- 2024
44. On the reconstruction limits of complex networks
- Author
-
Murphy, Charles, Lizotte, Simon, Thibault, François, Thibeault, Vincent, Desrosiers, Patrick, and Allard, Antoine
- Subjects
Statistics - Applications ,Computer Science - Information Theory ,Physics - Data Analysis, Statistics and Probability - Abstract
Network reconstruction consists in retrieving the -- hidden -- interaction structure of a system from empirical observations such as time series. Many reconstruction algorithms have been proposed, although less research has been devoted to describe their theoretical limitations. To this end, we adopt an information-theoretical point of view and define the reconstructability -- the fraction of structural information recoverable from data. The reconstructability depends on the true data generating model which is shown to set the reconstruction limit, i.e., the performance upper bound for all algorithms. We show that the reconstructability is related to various performance measures, such as the probability of error and the Jaccard similarity. In an empirical context where the true data generating model is unknown, we introduce the reconstruction index as an approximation of the reconstructability. We find that performing model selection is crucial for the validity of the reconstruction index as a proxy of the reconstructability, and illustrate how it assesses the reconstruction limit of empirical time series and networks.
- Published
- 2024
45. Motivic Mellin transforms
- Author
-
Cluckers, Raf, Loeser, François, Nguyen, Kien Huu, and Vermeulen, Floris
- Subjects
Mathematics - Algebraic Geometry ,Mathematics - Logic ,Mathematics - Number Theory - Abstract
This work brings Mellin transforms into the realm of motivic integration. The new, larger class of motivic functions is stable under motivic Mellin and Fourier transforms, with general Fubini results and change of variables formulas. It specializes to $p$-adic integrals and $p$-adic Mellin transforms uniformly in $p$, with transfer principles between zero and positive characteristic local fields. In particular, it generalizes previous set-ups of motivic integration with Fubini from among others [16, 17, 18, 29, 9] and simplifies some aspects on the way by using the ideas of [10].
- Published
- 2024
46. A Tale of Three: Magnetic Fields along the Orion Integral-Shaped Filament as Revealed by JCMT BISTRO survey
- Author
-
Wu, Jintai, Qiu, Keping, Poidevin, Frederick, Bastien, Pierre, Liu, Junhao, Ching, Tao-Chung, Bourke, Tyler L., Ward-Thompson, Derek, Pattle, Kate, Johnstone, Doug, Koch, Patrick M., Arzoumanian, Doris, Lee, Chang Won, Fanciullo, Lapo, Onaka, Takashi, Hwang, Jihye, Gouellec, Valentin J. M. Le, Soam, Archana, Tamura, Motohide, Tahani, Mehrnoosh, Eswaraiah, Chakali, Li, Hua-Bai, Berry, David, Furuya, Ray S., Coude, Simon, Kwon, Woojin, Lin, Sheng-Jun, Wang, Jia-Wei, Hasegawa, Tetsuo, Lai, Shih-Ping, Byun, Do-Young, Chen, Zhiwei, Chen, Huei-Ru Vivien, Chen, Wen Ping, Chen, Mike, Cho, Jungyeon, Choi, Youngwoo, Choi, Yunhee, Choi, Minho, Chrysostomou, Antonio, Chung, Eun Jung, Dai, Sophia, Di Francesco, James, Diep, Pham Ngoc, Doi, Yasuo, Duan, Hao-Yuan, Duan, Yan, Eden, David, Fiege, Jason, Fissel, Laura M., Franzmann, Erica, Friberg, Per, Friesen, Rachel, Fuller, Gary, Gledhill, Tim, Graves, Sarah, Greaves, Jane, Griffin, Matt, Gu, Qilao, Han, Ilseung, Hayashi, Saeko, Hoang, Thiem, Houde, Martin, Inoue, Tsuyoshi, Inutsuka, Shu-ichiro, Iwasaki, Kazunari, Jeong, Il-Gyo, Konyves, Vera, Kang, Ji-hyun, Kang, Miju, Karoly, Janik, Kataoka, Akimasa, Kawabata, Koji, Kim, Shinyoung, Kim, Mi-Ryang, Kim, Kyoung Hee, Kim, Kee-Tae, Kim, Jongsoo, Kim, Hyosung, Kim, Gwanjeong, Kirchschlager, Florian, Kirk, Jason, Kobayashi, Masato I. N., Kusune, Takayoshi, Kwon, Jungmi, Lacaille, Kevin, Law, Chi-Yan, Lee, Hyeseung, Lee, Chin-Fei, Lee, Sang-Sung, Lee, Jeong-Eun, Li, Dalei, Li, Di, Li, Guangxing, Liu, Sheng-Yuan, Liu, Tie, Liu, Hong-Li, Lu, Xing, Lyo, A-Ran, Mairs, Steve, Matsumura, Masafumi, Matthews, Brenda, Moriarty-Schieven, Gerald, Nagata, Tetsuya, Nakamura, Fumitaka, Nakanishi, Hiroyuki, Ngoc, Nguyen Bich, Ohashi, Nagayoshi, Park, Geumsook, Parsons, Harriet, Peretto, Nicolas, Priestley, Felix, Pyo, Tae-Soo, Qian, Lei, Rao, Ramprasad, Rawlings, Jonathan, Rawlings, Mark, Retter, Brendan, Richer, John, Rigby, Andrew, Sadavoy, Sarah, Saito, Hiro, Savini, Giorgio, Seta, Masumichi, Sharma, Ekta, Shimajiri, Yoshito, Shinnaga, Hiroko, Tang, Ya-Wen, Tang, Xindi, Thuong, Hoang Duc, Tomisaka, Kohji, Tram, Le Ngoc, Tsukamoto, Yusuke, Viti, Serena, Wang, Hongchi, Whitworth, Anthony, Xie, Jinjin, Yang, Meng-Zhe, Yen, Hsi-Wei, Yoo, Hyunju, Yuan, Jinghua, Yun, Hyeong-Sik, Zenko, Tetsuya, Zhang, Guoyin, Zhang, Chuan-Peng, Zhang, Yapeng, Zhou, Jianjun, Zhu, Lei, de Looze, Ilse, Andre, Philippe, Dowell, C. Darren, Eyres, Stewart, Falle, Sam, Robitaille, Jean-Francois, and van Loo, Sven
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
As part of the BISTRO survey, we present JCMT 850 $\mu$m polarimetric observations towards the Orion Integral-Shaped Filament (ISF) that covers three portions known as OMC-1, OMC-2, and OMC-3. The magnetic field threading the ISF seen in the JCMT POL-2 map appears as a tale of three: pinched for OMC-1, twisted for OMC-2, and nearly uniform for OMC-3. A multi-scale analysis shows that the magnetic field structure in OMC-3 is very consistent at all the scales, whereas the field structure in OMC-2 shows no correlation across different scales. In OMC-1, the field retains its mean orientation from large to small scales, but shows some deviations at small scales. Histograms of relative orientations between the magnetic field and filaments reveal a bimodal distribution for OMC-1, a relatively random distribution for OMC-2, and a distribution with a predominant peak at 90$^\circ$ for OMC-3. Furthermore, the magnetic fields in OMC-1 and OMC-3 both appear to be aligned perpendicular to the fibers, which are denser structures within the filament, but the field in OMC-2 is aligned along with the fibers. All these suggest that gravity, turbulence, and magnetic field are each playing a leading role in OMC-1, 2, and 3, respectively. While OMC-2 and 3 have almost the same gas mass, density, and non-thermal velocity dispersion, there are on average younger and fewer young stellar objects in OMC-3, providing evidence that a stronger magnetic field will induce slower and less efficient star formation in molecular clouds., Comment: published in the ApJ Letters
- Published
- 2024
- Full Text
- View/download PDF
47. Investigating Length Issues in Document-level Machine Translation
- Author
-
Peng, Ziqian, Bawden, Rachel, and Yvon, François
- Subjects
Computer Science - Computation and Language - Abstract
Transformer architectures are increasingly effective at processing and generating very long chunks of texts, opening new perspectives for document-level machine translation (MT). In this work, we challenge the ability of MT systems to handle texts comprising up to several thousands of tokens. We design and implement a new approach designed to precisely measure the effect of length increments on MT outputs. Our experiments with two representative architectures unambiguously show that (a)~translation performance decreases with the length of the input text; (b)~the position of sentences within the document matters and translation quality is higher for sentences occurring earlier in a document. We further show that manipulating the distribution of document lengths and of positional embeddings only marginally mitigates such problems. Our results suggest that even though document-level MT is computationally feasible, it does not yet match the performance of sentence-based MT., Comment: Under review
- Published
- 2024
48. Failure of Orthogonality of Rounded Fourier Bases
- Author
-
Clément, François and Steinerberger, Stefan
- Subjects
Mathematics - Classical Analysis and ODEs - Abstract
The purpose of this note is to prove estimates for $$ \left| \sum_{k=1}^{n} \mbox{sign} \left( \cos \left( \frac{2\pi a}{n} k \right) \right) \mbox{sign} \left( \cos \left( \frac{2\pi b}{n} k \right) \right)\right|,$$ when $n$ is prime and $a,b \in \mathbb{N}$. We show that the expression can only be large if $a^{-1}b \in \mathbb{F}_n$ (or a small multiple thereof) is close to $1$. This explains some of the surprising line patterns in $A^T A$ when $A \in \mathbb{R}^{n \times n}$ is the signed discrete cosine transform. Similar results seem to exist at a great level of generality.
- Published
- 2024
49. Multiresolution relaxation times lattice Boltzmann schemes with projection
- Author
-
Dubois, François and Philippi, Paulo Cesar
- Subjects
Nonlinear Sciences - Cellular Automata and Lattice Gases - Abstract
We propose to extend the multiresolution relaxation times lattice Boltzmann schemes with an additional projection step. For the explicit example of the D2Q9 scheme, we define this extended method. We prove that in general the projection step does not change the asymptotic partial differential equations at second order. We present four numerical test cases. One concerns linear stability with a Fourier analysis with a single-vertex scheme. Three bidimensional fluid flows with a coarse mesh have been tested: the Minion and Brown sheared flow, the Ghia, Ghia and Shin lid-driven cavity and an unsteady acoustic wave. Our results indicate that the bulk viscosity can be dramatically reduced with a better stability than the initial scheme.
- Published
- 2024
50. Beyond Gradient Averaging in Parallel Optimization: Improved Robustness through Gradient Agreement Filtering
- Author
-
Chaubard, Francois, Eddy, Duncan, and Kochenderfer, Mykel J.
- Subjects
Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
We introduce Gradient Agreement Filtering (GAF) to improve on gradient averaging in distributed deep learning optimization. Traditional distributed data-parallel stochastic gradient descent involves averaging gradients of microbatches to calculate a macrobatch gradient that is then used to update model parameters. We find that gradients across microbatches are often orthogonal or negatively correlated, especially in late stages of training, which leads to memorization of the training set, reducing generalization. In this paper, we introduce a simple, computationally effective way to reduce gradient variance by computing the cosine distance between micro-gradients during training and filtering out conflicting updates prior to averaging. We improve validation accuracy with significantly smaller microbatch sizes. We also show this reduces memorizing noisy labels. We demonstrate the effectiveness of this technique on standard image classification benchmarks including CIFAR-100 and CIFAR-100N-Fine. We show this technique consistently outperforms validation accuracy, in some cases by up to 18.2\% compared to traditional training approaches while reducing the computation required nearly an order of magnitude because we can now rely on smaller microbatch sizes without destabilizing training.
- Published
- 2024
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.