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1. miR-374 family is a key regulator of chronic primary pain onset

Author

Nathaniel P. Hernandez, Ashleigh Rawls, Jiegen Chen, Xin Zhang, Yaomin Wang, Xianglong Gao, Marc Parisien, Mohamad Karaky, Carolina Beraldo Meloto, Francesca Montagna, Hong Dang, Yue Pan, Ying Zhao, Samuel McLean, Sarah Linnstaedt, Luda Diatchenko, and Andrea G. Nackley

Subjects
Anesthesiology, RD78.3-87.3
Abstract

Abstract. Introduction:. Chronic primary pain conditions (CPPCs) are linked to catecholamine activation of peripheral adrenergic receptors. Yet, catecholamine-dependent epigenetic mechanisms, such as microRNA (miRNA) regulation of mRNA transcripts, remain largely unknown. Objectives:. We sought to identify RNA species correlated with case status in 3 pain cohorts, to validate RNAs found to be dysregulated in a mouse model of CPPC onset, and to directly test the role of adrenergic receptors in miRNA regulation. Furthermore, we tested antinociceptive effects of miR-374 overexpression. Methods:. We used RNA-seq and quantitative reverse transcription polymerase chain reaction to measure RNA expression in 3 pain cohorts. Next, we validated identified RNAs with quantitative reverse transcription polymerase chain reaction in a mouse model of CPPC onset, measuring expression in plasma, peripheral (adipose, muscle, dorsal root ganglia [DRG]), and central (spinal cord) tissues. Then, we stimulated adrenergic receptors in primary adipocyte and DRG cultures to directly test regulation of microRNAs by adrenergic signaling. Furthermore, we used in vitro calcium imaging to measure the antinociceptive effects of miR-374 overexpression. Results:. We found that one miRNA family, miR-374, was downregulated in the plasma of individuals with temporomandibular disorder, fibromyalgia syndrome, or widespread pain following a motor vehicle collision. miR-374 was also downregulated in plasma, white adipose tissue, and spinal cord from mice with multisite mechanical sensitivity. miR-374 downregulation in plasma and spinal cord was female specific. Norepinephrine stimulation of primary adipocytes, but not DRG, led to decreased miR-374 expression. Furthermore, we identified tissue-specific and sex-specific changes in the expression of predicted miR-374 mRNA targets, including known (HIF1A, NUMB, TGFBR2) and new (ATXN7, CRK-II) pain targets. Finally, we demonstrated that miR-374 overexpression in DRG neurons reduced capsaicin-induced nociceptor activity. Conclusions:. Downregulation of miR-374 occurs between adrenergic receptor activation and mechanical hypersensitivity, and its adipocyte source implicates adipose signaling in nociception. Further study of miR-374 may inform therapeutic strategies for the millions worldwide who experience CPPCs.

Published
2024
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2. Trajectories of pain and depressive symptoms among people living with low back pain during the COVID-19 pandemic: a 24-month longitudinal study

Author

Adriana Angarita-Fonseca, Mathieu Roy, Anaïs Lacasse, Guillaume Léonard, Pierre Rainville, Marie-France Marin, Iulia Tufa, Erika L. Gentile, M. Gabrielle Pagé, Jean-Sébastien Roy, Hugo-Massé Alarie, Carolina B. Meloto, Erika Lauren Gentile, Erwan Leclair, Francesca Montagna, Julien Goulet, Laura S. Stone, Laurent Dupuis, Luda Diatchenko, Manon Choinière, Rubens da Silva, Martin Descarreaux, Maryse Fortin, Pierre Langevin, Mark Ware, Pascal Tétreault, Richard Hovey, Simon Deslauriers, Stephanie Grégoire, and Timothy Wideman

Subjects
Anesthesiology, RD78.3-87.3
Abstract

Abstract. Introduction: We explored trajectories of pain intensity and depressive symptoms over the first 24 months of the pandemic in people with low back pain. Methods: This longitudinal study was conducted alongside the Quebec Low Back Pain Study. Starting in April 2020 and every 3 months until July 2022, 291 participants completed an online survey. Group-based trajectory modeling was used to identify patterns of pain intensity and depressive symptoms. Onset outbreak characteristics were then put in relation with trajectory groups using multivariate logistic regression. Results: The analysis revealed 5 trajectories of pain intensity and depressive symptoms, respectively. The pain trajectories were stable mild (n = 17, 5.8%); stable moderate (n = 103, 35.4%); stable severe (n = 81, 27.8%); U-shape (n = 24, 8.3%), and inverted U-shape (n = 66, 22.7%). The trajectories of depressive symptoms were stable none (n = 58, 19.9%); stable very mild (n = 61, 21.0%); stable mild (n = 85, 29.2%); stable moderate (n = 59, 21.7%); and severe slightly improving (n = 24, 8.3%). Pre-COVID everyday/nearly everyday pain, average pain intensity, and widespread bodily pain were predictive of pain trajectory groups. Higher pre-COVID depression, acute stress disorder, and lockdown measures-related stress were associated with moderate/severe depressive trajectories. Discussion: Our findings indicated relative stability of pain and depressive symptoms among participants during the COVID-19 pandemic but also highlighted subgroups of people who experienced temporary deterioration or improvement over the first months of the pandemic that then reverted back to baseline levels. Modifiable risk factors were identified before the onset of the pandemic, which could give preventive measures in targeted populations.

Published
2024
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3. An Experimental Protocol for Human Stress Investigation in Manufacturing Contexts: Its Application in the NO-STRESS Project

Author

Ainhoa Apraiz, Ganix Lasa, Francesca Montagna, Graziana Blandino, Erika Triviño-Tonato, and Angel Dacal-Nieto

Subjects
stress measurement, Industry 5.0, experimental protocol, human factors, human-centered, assessment, Systems engineering, TA168, Technology (General), T1-995
Abstract

Stress is a critical concern in manufacturing environments, as it impacts the well-being and performance of workers. Accurate measurement of stress is essential for effective intervention and mitigation strategies. This paper introduces a holistic and human-centered protocol to measure stress in manufacturing settings. The three-phased protocol integrates the analysis of physiological signals, performance indicators, and the human perception of stress. The protocol incorporates advanced techniques, such as electroencephalography (EEG), heart rate variability (HRV), galvanic skin response (GSR), and electromyography (EMG), to capture physiological responses associated with stress. Furthermore, the protocol considers performance indicators as an additional dimension of stress measurement. Indicators such as task execution time, errors, production rate, and other relevant performance metrics contribute to a comprehensive understanding of stress in manufacturing environments. The human perception of stress is also integrated into the protocol, recognizing the subjective experience of the individual. This component captures self-assessment and subjective reports, allowing for a more nuanced evaluation of stress levels. By adopting a holistic and human-centered approach, the proposed protocol aims to enhance our understanding of stress factors in manufacturing environments. The protocol was also applied in the automotive industry and plastic component manufacturing. The insights gained from this protocol can inform targeted interventions to improve worker well-being, productivity, and overall organizational performance.

Published
2023
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4. Tackling the Design of Platform-Based Service Systems, Integrating Data and Cultures: The Case of Urban Markets

Author

Francesca Montagna, Giulia Marcocchia, and Marco Cantamessa

Subjects
service system platforms, data-enabled design, urban markets, Systems engineering, TA168, Technology (General), T1-995
Abstract

Different design traditions address the design of services. When adopted alone, they can limit design, especially if services systems are complex. Some combinations among service design traditions are theorized in the literature and a cultural synthesis is considered a priority. This paper discusses a practical application of that synthesis: systematic/data-driven methods from engineering and service innovation are applied within a participatory and transformative environment. Intangible versus material and functional versus experience service elements are considered. The case study on urban markets shows that economics and the transactional/functional mechanics of a service system must be understood for proper design actions, and that overcoming separations between strands of literature is necessary to achieve this aim. Moreover, since urban markets are two-sided platforms in a physical setting, the study allows easier investigation than in modern digital platforms regarding how platform economics affect the design of a service system, providing insights for digital services as well. Originality is due to generally scant contributions on urban market design, since markets are often regulated, rather than designed, beyond the rare practical attempts of cultural synthesis.

Published
2023
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5. Data-driven design: the new challenges of digitalization on product design and development

Author

Marco Cantamessa, Francesca Montagna, Stefania Altavilla, and Alessandro Casagrande-Seretti

Subjects
data-driven design, digitalisation, digital design paradigm, Drawing. Design. Illustration, NC1-1940, Engineering design, TA174
Abstract

Digitalization and the momentous role being assumed by data are commonly viewed as pervasive phenomena whose impact is felt in all aspects of society and the economy. Design activity is by no means immune from this trend, and the relationship between digitalization and design is decades old. However, what is the current impact of this ‘data revolution’ on design? How will the design activity change? What are the resulting research questions of interest to academics? What are the main challenges for firms and for educational institutions having to cope with this change? The paper provides a comprehensive conceptual framework, based on recent literature and anecdotal evidence from the industry. It identifies three main streams: namely the consequences on designers, the consequences on design processes and the role of methods for data analytics. In turn, these three streams lead to implications at individual, organizational and managerial level, and several questions arise worthy of defining future research agendas. Moreover, the paper introduces relational diagrams depicting the interactions between the objects and the actors involved in the design process and suggests that what is occurring is by no means a simple evolution but a paradigmatic shift in the way artefacts are designed.

Published
2020
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6. Unpacking the innovation toolbox for design research and practice

Author

Francesca Montagna and Marco Cantamessa

Subjects
innovation, design research, design practice, Drawing. Design. Illustration, NC1-1940, Engineering design, TA174
Abstract

The terms design and innovation are intuitively related, but the relationship between these two concepts is more complex and subtle than it appears at first sight. Few authors have made rigorous attempts to explore this relationship in depth, and the contributions present in the literature generally suffer the specialist backgrounds on which they are grounded. Consequently, this paper provides a high-level synthesis of the innovation management domain and defines an original framework that allows the positioning of the concepts from Innovation Management that are most relevant for scholars and practitioners operating in the Design domain. Specifically, this framework provides a concise representation of the typologies of innovation activities along the technology lifecycle, and associates them to their business implications and to technical and organizational implications on the design process. This framework allows scholars and practitioners from both fields to identify the typical design challenges that are inherent to each type of innovation activity, and to evaluate the suitability of specific support methods and tools.

Published
2019
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7. Trattamento del danno renale da iperbilirubinemia mediante plasma adsorbimento/perfusione

Author

Giuseppe Sileno, Teresa Rampino, Gianluca Marchi, Maria Luisa Scaramuzzi, Gianluca Fasoli, Francesca Montagna, Antonio Dal Canton, and Pasquale Esposito

Subjects
Bilirubina, Ittero, Danno renale acuto, Plasma adsorbimento, Internal medicine, RC31-1245, Diseases of the genitourinary system. Urology, RC870-923
Abstract

L'iperbilirubinemia severa si associa spesso al danno renale acuto (AKI), soprattutto in pazienti con livelli di bilirubinemia pari a 20–25 mg/dL. Considerando la potenziale tossicità renale della bilirubina, è possibile che la rimozione di tale sostanza dal plasma rappresenti un modo per migliorare la funzione renale nei pazienti con AKI associato a iperbilirubinemia. Qui presentiamo il caso di un uomo di 47 anni, ricoverato per ittero ingravescente e ascite. All'anamnesi il paziente presentava una mielofibrosi idiopatica, associata a epatopatia con valori di bilirubina stabili intorno ai 4 mg/dL. Al momento del ricovero, la bilirubinemia era pari a 45 mg/dL, con valori di creatininemia di 2.1 mg (valore precedente 0.7 mg/dL). La biopsia epatica mostrava un quadro di severa colangite linfogranulocitaria. Per il peggioramento del quadro ematochimico (bilirubinemia 59.7 mg/dL e creatininemia 4 mg/dL), una volta escluse cause funzionali di insufficienza renale e la sindrome epato-renale, sospettando un danno renale da iperbilirubinemia, abbiamo iniziato il trattamento con plasma adsorbimento/perfusione (PAP). Tale metodica si basa sulla rimozione selettiva della bilirubina dal plasma mediante una specifica resina adsorbente. Dopo il trattamento, si assisteva a una riduzione dei livelli di bilirubina sierica fino a 24 mg/dL, associata a un significativo miglioramento della funzione renale. Tuttavia, circa dieci giorni dopo l'inizio della PAP, il paziente decedeva per shock settico. Questo caso rappresenta un'ulteriore prova della potenziale nefrotossicità della bilirubina, suggerendo che la PAP potrebbe essere una valida opzione terapeutica nei pazienti con danno renale acuto secondario a iperbilirubinemia.

Published
2013
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8. Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

Author

Rispoli, Vincenzo, Malara, Alba, Spadea, Fausto, Di Cello, Serena, Ceravolo, Francesco, Fabiano, Francesco, Chiaradia, Giuseppe, Gabriele, Amedeo, Lenino, Peluso, Andrea, Taristano, Settembrini, Vincenzo, Capomolla, Domenico, Citrino, Antonella, Scriva, Antonietta, Bruno, Irene, Secchi, Roberto, De Martino, Eugenio, Muccinelli, Roberto, Lupi, Gerardo, Paonessa, Patrizio, Fabbri, Andrea, Passuti, Maria Teresa, Castellari, Sofia, Po, Andrea, Gaggioli, Guido, Varesi, Massimo, Moneti, Paolo, Capurso, Sebastiano, Latini, Vincenzo, Ghidotti, Stefano, Riccardelli, Francesco, Macchi, Maurizio, Rigo, Rosaria, Claudio, Pascale, Angelo, Bosio, Flavio, Cerrato, Benedetta, Bardelli, Boffelli, Stefano, Cassinadri, Angela, Franzoni, Simone, Spazzini, Elena, Andretto, Daniela, Tonini, Gabriele, Andreani, Laura, Coralli, Mirco, Balotta, Antonio, Cancelliere, Roberto, Ballardini, Giorgio, Simoncelli, Margherita, Mancini, Annarita, Strazzacapa, Mara, Fabio, Stefano, De Filippi, Francesco, Giudice, Chiara, Dentizzi, Cosimo, Azzini, Margherita, Cazzadori, Marco, Mastroeni, Valeria, Bertassello, Paolo, Claudia Benati, Helena Santana, Nesta, Elisa, Tobaldini, Chiara, Guerini, Fabio, Elena, Tambara, Mombelloni, Paolo, Fontanini, Fulvio, Gabriella, Lassa, Pizzorni, Crosio, Oliverio, Martina, Del Grosso, Luciano Luca, Giavedoni, Cristina, Bidoli, Giuliano, Mazzei, Bruno, Corsonello, Andrea, Fusco, Sergio, Vena, Silvio, De Vuono, Tommaso, Maiuri, Giorgio, Luca, Fimognari Filippo, Andrea, Arone, Giovanni, Sgrò, Rossella, Nicolazzo, Castegnaro, Eugenio, De Rosa, Salvatore, Sechi, Rossella Bazzano, Benvenuti, Enrico, Del Lungo, Ilaria, Giardini, Sante, Giulietti, Chiara, Mauro, Di Bari, Eleonora, Barghini, Martina, Paoli, Irene, Fiordelli, Riccardo, Barucci, Federica, Sgrilli, Ilaria, Del Lungo, Bertoletti, Erik, D'Amico, Ferdinando, Caronzolo, Francesco, Grippa, Alessandro, Lombardo, Giuseppina, Pipicella, Tiziana, Antonino, Saitta, Francesco, Corica, Valeria, Prestipino Giarritta, Daniela, Larosa, Domenico, Cucinotta, Giorgio, Basile, March, Albert, Nitti, Maria Teresa, Felici, Alessandro, Pavan, Silvia, Piazzani, Fabrizio, Lunelli, Alessandra, Dimori, Sergio, Margotta, Alessandro, Soglia, Tiziano, Postacchini, Demetrio, Brunelli, Roberto, Santini, Silvia, Francavilla, Monia, Macchiati, Ilenia, Sorvillo, Francesca, Giuli, Cinzia, Mecocci, Patrizia, Longo, Annalisa, Perticone, Francesco, Addesi, Desireè, Rosa, Paola Cerra, Bencardino, Giuseppe, Falbo, Tania, Grillo, Nadia, Marco, Filice, Mirella, Flippo, Fantò, Fausto, Isaia, Gianluca, Pezzilli, Stella, Bergamo, Daniele, Furno, Elisabetta, Rrodhe, Sokol, Lucarini, Simonetta, Dijk, Babette, Dall'Acqua, Francesca, Cappelletto, Francesco, Calvani, Donatella, Becheri, Dimitri, Giuseppe, Mottino, Costanza, Mitidieri, Vito, Antonio, Francesca, Bartalucci, Magherini, Lorenza, Novella, Malin, Franca, Boni, Lucia Gambardella, Paoli Martina, Valente, Carlo, Ilaria, Bracali, Alice, Foschini, Bo, Mario, Porrino, Paola, Ceci, Giacomo, Giuliana, Bottignole, Michela, Tibaldi, Eleonora, Coppo, Ettore, Evaristo, Camellini, Cinzia, Servello, Adriana, Grassi, Alessandro, Rozzini, Renzo, Tironi, Sara, Grassi, Maria Grazia, Troisi, Elio, Carlo, Caltagirone, Simona Gabriella, Di Santo, Flaminia, Franchini, Federica, Ratto, Beatrice, Pavoni, Sofia, Toniolo, Gabutto, Anna, Quazzo, Loredana, Rosatello, Annalisa, Suraci, Domenico, Tagliabue, Benedetta, Perrone, Chiara, Ferrara, Lucia, Castagna, Alberto, Tremolada, Maria Luisa, Giuseppe, Castoldi, Stefano, Barbero, Davide, Oltramonti, Piano, Simonetta, Serviddio, Gaetano, Lo Buglio, Aurelio, Gurrera, Tiziana, Merlo, Valeria, Rovai, Carla, Cotroneo, Antonino Maria, Carlucci, Rosaria, Abbaldo, Anna, Monzani, Fabio, Qasem, Ahmad Amedeo, Bini, Giacomo, Tafuto, Silvia, Galli, Giovanni, Bruni, Amalia Cecilia, Mancuso, Giovanna, Mancuso, Gerardo, Calipari, Daniela, Giuseppe Massimiliano, De Luca, Bernardini, Bruno, Corsini, Carla, Michele, Ciccarelli, Sara, Dal Farra, Cagnin, Annachiara, Fragiacomo, Federica, Pompanin, Sara, Piero, Amodio, Marco, Cagnin, Zurlo, Amedeo, Guerra, Gianluca, Pala, Marco, Menozzi, Luca, Gatti, Chiara Delli, Magon, Stefania, Roberto, Manfredini, Alfredo, De Giorgi, Fabio, Fabbian, Ruana, Tiseo, Elisa, Misurati, Benedetta, Boari, Christian, Molino, Marco, Pala, Massimo, Gallerani, Di Francesco, Vincenzo, Faccioli, Silvia, Pellizzari, Luca, Giorgia, Fontana, Barbagallo, Giuseppe, Lunardelli, Maria Lia, Martini, Emilio, Ferrari, Eleonora, Macchiarulo, Maria, Corneli, Maria, Bacci, Monica, Battaglia, Giuseppe, Anastasio, Luigi, Lo Storto, Mario Sostene, Seresin, Chiara, Simonato, Matteo, Loreggian, Michele, Cestonaro, Fausta, Durando, Mario, Latella, Raffaele, Mazzoleni, Marta, Russo, Giuseppe, Ponte, Martino, Valchera, Alessandro, Salustri, Giuseppe, Petritola, Donatella, Costa, Alfredo, Sinforiani, Elena, Cotta, Matteo Ramusino, Pizio, Renato Nicola, Cester, Alberto, Formilan, Marino, Pietro, Bonometto, Carbone, Pasqualina, Cazzaniga, Ilaria, Appollonio, Ildebrando, Cereda, Diletta, Stabile, Andrea, Xhani, Rubjona, Acampora, Roberto, Tremolizzo, Lucio, Federico, Pieruzzi, Antonio, Ciaccio, Valerio, Pontecorvi, Cesare, Burti, Zhirajr, Mokini, Giovanni, Vitale, Maria, Amigoni, Mariaelena, Sparacino, Bottacchi, Edo, Bucciantini, Elisabetta, Di Giovanni, Marco, Franchi, Fabrizio, Lucchetti, Lucio, Mariani, Claudio, Grande, Giulia, Rapazzini, Piero, Marco, Mauri, Romanelli, Giuseppe, Marengoni, Alessandra, Franco, Nicosia, Alessio, Margola, Stefano, Bonardelli, Nicola, Latronico, Laura, Porcella, Nazario, Portolani, Carlo, Concoreggi, Chiara, Grassini, Soccorso, Pronto, Andrea, Salvi, Luca, Bianchetti, Francesca, Spagnoli, Roberto, Apuzzo, Marco, Fontanella, Anna, Ceraso, Francesco, Castelli, Fugazza, Luciano, Guerrini, Chiara, De Paduanis, Giovanna, Iallonardo, Lucia, Palumbo, Pasquale, Zuliani, Giovanni, Ortolani, Beatrice, Capatti, Eleonora, Soavi, Cecilia, Bianchi, Lara, Francesconi, Daniela, Miselli, Agata, Gloria, Brombo, Tommaso, Romagnoli, Chiara, Pazzaglini, Agata, Miselli Maria, Marco, Dall'Agata, Luca, Menozzi, Gianluca, Guerra, Suardi, Teresa, Mazzone, Andrea, Zaccarini, Cinzia, Manuela, Riva, Mirra, Gianluca, Muti, Ettore, Bottura, Renato, Gianpaolo, Moretti, Secreto, Piero, Bisio, Erika, Cecchettani, Marco, Naldi, Tamara, Pallavicino, Alessandra, Pugliese, Michela, Iozzo, Rosaria Cosima, Grassi, Guido, Michele, Bombelli, Raffaella, Dell'Oro, Fosca, Quarti Trevano, Giorgio, Giussani Carlo, Giovanni, Paternò, Ernesto, Contro, Mannironi, Antonio, Giorli, Elisa, Oberti, Sara, Fierro, Brigida, Piccoli, Tommaso, Giacalone, Fabio, Mandas, Antonella, Serchisu, Luca, Costaggiu, Diego, Pinna, Elisa, Orrù, Francesca, Mannai, Martina, Cordioli, Zeno, Pelizzari, Luca, Turcato, Emanuela, Arduini, Pietro, Cacace, Carlo, Chiloiro, Roberta, Cimino, Rosella, Ruberto, Carmen, Giovanni, Ruotolo, Pietro, Gareri, Laura, Greco, Alberto, Castagna, Carmen, Ruberto, Santo, Pierluigi Dal, Andriolli, Antonino, Burattin, Giuseppe, Rossi, Laura, Andreolli Antonino, Cervati Giovanna, Giuseppe, Catalano, Tezza, Fabiana, Maddalena, Pizzardini, Laura, Stievano, Crippa, Patrizia, Aloisio, Paola, Di Monda, Tiziana, Malighetti, Alessandro, Galbassini, Gloria, Salutis, Domus, Ivaldi, Claudio, Russo, Anna Maria, Bennati, Ettore, Pino, Elisabetta, Zavarise, Gianmaria, Pesci, Alberto, Suigo, Giulia, Faverio, Paola, Andrea, Gori, Sabrina, Perego, Zanasi, Massimo, Moniello, Giovanni, Rostagno, Carlo, Cartei, Alessandro, Polidori, Gianluca, Ungar, Andrea, Melis, Maria Ramona, Martellini, Eleonora, Enrico, Mossello, Monica, Torrini, Antonella, Giordano, Giovanna, Leone, Migliorini, Marta, Caramelli, Francesca, Battiston, Bruno, Berardino, Maurizio, Cavallo, Simona, Alessandro, Massè, Anna, Santoro, Lombardi, Bruna, D'Ippolito, Pierpaolo, Furini, Angela, Villani, Daniele, Clara, Raimondi, Guarneri, Massimo, Paolucci, Stefano, Bassi, Andrea, Coiro, Paola, De Angelis, Domenico, Morone, Giovanni, Venturiero, Vincenzo, Palleschi, Lorenzo, Raganato, Paolo, Di Niro, Giuseppina, Rosa, Casini Anna, Loredana, Bove, Imoscopi, Alessandra, Isaia, Giancarlo, Tibaldi, V., Bottignole G, G., Calvi, E., Clementi, C., Zanocchi, M., Agosta, L., Nortarelli, Antonella, Provenzano, Giuseppe, Mari, Daniela, Romano, Federica Ylenia, Rosini, Francesca, Mansi, Marta, Rossi, Silvia, Geriatria, Alex Riccardelli, Inzaghi, Lorenzo, Bonini, Giulia, Rossi, Paolo, Potena, Alfredo, Lichii, Mihaela, Candiani, Tiziana, Grimaldi, William, Bertani, Emiliano, Alessandra, Porta, Calogero, Pietro, Pinto, Daniela, Bernardi, Roberto, Nicolino, Francesco, Galetti, Caterina, Gianstefani, Alice, Giulia, Corvalli, Lorenzo, Mulazzani, Odetti, Patrizio, Monacelli, Fiammetta, Prefumo, Matteo, Fiammetta, Monacelli, Canepa, Marta, Minaglia, Cecilia, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Prestano, Raffaele, Dalise, Anna Maria, Barra, Davide, Bosco, Livio Dal, Asprinio, Vincenzo, Dallape, Luciana, Perina, Elisa, Incalzi, Raffaele Antonelli, Bartoli, Isaura Rossi, Pluderi, Alice, Maina, Antonella, Pecoraro, Elisabetta, Sciarra, Michela, Prudente, Angela, Paola, Maina, Francesca, Mete, Manuel, Ventura, Luisella, Cesari, Maria, Pernigotti Luigi, Tina, Santangelo, Benini, Lucia, Levato, Francesco, Mhiuta, Victor, Alius, Florin, Davidoaia, Diana, Giardini, Vittorio, Garancini, Mattia, Bellamoli, Claudio, Terranova, Luciano, Bozzini, Claudia, Tosoni, Paolo, Provoli, Emma, Cascone, Luisa, Dioli, Andrea, Ferrarin, Gianfranco, Bucci, Adelmo, Bua, Guido, Fenu, Sara, Bianchi, Giovanna, Casella, Silvia, Romano, Valentina, Maurizio, Poli, Mascherona, Ilenia, Belotti, Gloria, Cavaliere, Sabina, Cuni, Estella, Merciuc, Nina, Oberti, Rosella, Veneziani, Silvia, Capoferri, Emanuela, De Bernardi, Elisabetta, Colombo, Katia, Bravi, Marco, Nicoletta, Negrinotti, D'Arcangelo, Paolo, Montenegro, Nicola, Montanari, Roberto, Lamanna, Pierpaolo, Gasperini, Beatrice, Isabella, Montesi, Stefania, Diotallevi, Gaia, Altobelli, Filippo, Calcinaro, Palamà, Chiara, Di Emidio, Chiara, Scarpini, Elio, Arighi, Andrea, Fumagalli, Giorgio, Basilico, Paola, De Amicis Margherita, Migone, Marta, Mancarella, Diletta, Maira, Granata, Antonino, Ranalli, Claudia, Cammilli, Alessandra, Cavallini, Maria Chiara, Tricca, Manola, Natella, Daniela, Gabbani, Luciano, Tesi, Francesca, Martella, Letizia, Imbrici, Rosalba, Guerrini, Gianbattista, Scotuzzi, Anna Maria, Sozzi, Ferdinando, Valenti, Luigi, Chiarello, Antonino, Monia, Monella, Pilotto, Alberto, Prete, Camilla, Senesi, Barbara, Meta, Anna Cristina, Pendenza, Enrico, Pasqualetti, Giuseppe, Polini, Antonio, Tognini, Sara, Ballino, Elena, Cherubini, Antonio, Dell'Aquila, Giuseppina, Gasparrini, Pina Maria, Marotti, Elisabetta, Migale, Monica, Scrimieri, Antonia, Falsetti, Lorenzo, Salvi, Aldo, Toigo, Gabriele, Ceschia, Giuliano, Rosso, Alessia, Tongiorgi, Chiara, Scarpa, Cristina, Maurizio, Pacchioni, De Dominicis, Luigino, Pucci, Eugenio, Renzi, Sara, Cartechini, Elisabetta, Tomassini, Pia Francesca, Del Gobbo, Maurizio, Ugenti, Francesca, Romeo, Pasquale, Nardelli, Anna, Lauretani, Fulvio, Visioli, Sandra, Montanari, Ilaria, Ermini, Francesca, Giordano, Antonio, Pigato, Giorgio, Simeone, Emilio, Barbujani, Mario, Giampieri, Marina, Amoruso, Raffaele, Piccinini, Maristella, Ferrari, Camilla, Gambetti, Claudio, Sfrappini, Mario, Semeraro, Letizia, Striuli, Rinaldo, Mariani, Claudia, Pelliccioni, Giuseppe, Marinelli, Donatella, Fabi, Katia, Rossi, Tommaso, Pesallaccia, Martina, Sabbatini, Debora, Gobbi, Beatrice, Cerqua, Raffaella, Tagliani, Giancarla, Schlauser, Elena, Caser, Luciano, Caramello, Elisa, Sandigliano, Franca, Rosso, Giorgio, Ferrari, Alberto, Bendini, Chiara, Luisa, Davoli Maria, Casella, Monica, Prampolini, Raffaella, Scevola, Moreno, Vitale, Enrico, Roberto, Brugiolo, Carlo, Fagherazzi, Sergio, Fusco, Alberto, Scarpa, Daniela, Zara, Giulia, Bertozzo, Serena, Granziera, Michele, Barazzuol, Maugeri, Domenico, Sorace, Rosaria, Anzaldi, Massimiliano, De Gesu, Roberto, Morrone, Giuseppe, Davolio, Federica, Fabbo, Andrea, Palmieri, Marina, Zoli, Marco, Forti, Paola, Pirazzoli, Luca, Fabbri, Elisa, Terenzi, Laura, Bergolari, Federica, Wenter, Christian, Ruffini, Ingrid, Insam, Miriam, Abraham, Elisabeth, Kirchlechner, Christine, Cucinotta, Domenico, Antonino, Lasco, Basile, Giorgio, Grazia, Arena Maria, Parise, Pasquale, Boccali, Andrea, Amici, Serena, Gambacorta, Maurizia, Lasagni, Anna, Lovati, Roberto, Giovinazzo, Francesca, Kimak, Elzbieta, Zappa, Paolo, Medici, Francesco, Lo Castro, Marika, Mauro, Flavia, De Luca, Alessandro, Sancesario, Giuseppe, Martorana, Alessandro, Scaricamazza, Beatrice, Toniolo, Sofia, Di Lorenzo, Francesco, Liguori, Claudio, Lasco, Antonino, Vita, Natale, Giomi, Mirna, Forte, Floriana, Padovani, Alessandro, Rozzini, Luca, Ceraso, Anna, Salvatore, Caratozzolo, Cottino, Maria, Vitali, Silvia, Marelli, Eleonora, Tripi, Gabriele, Miceli, Salvatore, Urso, Giovanni, Grioni, Giuseppe, Vezzadini, Giuliana, Misaggi, Giulia, Forlani, Chiara, Avanzi, Stefano, Serena, Saulle, Claudia, Casarini, Marilena, Viggiano, Alberto, Luisa, Diego, Ghianda, Alessandro, Giordano, Iemolo, Francesco, Giordano, Antonello, Sanzaro, Enzo, D'Asta, Gabriele, Proietto, Maria, Carnemolla, Anna, Razza, Grazia, Spadaro, Daniela, Bertolotti, Marco, Mussi, Chiara, Neviani, Francesca, Roberto, Chiesa, Valentina, Guerzoni, Linda, Morselli, Francesca, Venturelli, Tarozzi, Adriano, Balestri, Francesca, Mannarino, Giulio, Bigolari, Michela, Natale, Alessia, Grassi, Simona, Bottaro, Cinzia, Stefanelli, Sara, Bovone, Ugo, Tortorolo, Umberto, Quadri, Roberto, Leone, Giuseppe, Ponzetto, Maria, Frasson, Paola, Annoni, Giorgio, Bellelli, Giuseppe, Bruni, Adriana, Confalonieri, Roberto, Corsi, Maurizio, Moretti, Daniela, Teruzzi, Fabiola, Umidi, Simona, Mazzola, Paolo, Perego, Sabrina, Persico, Ilaria, Olivieri, Giulia, Bonfanti, Alessandra, Hajnalka, Szabò, Galeazzi, Marianna, Massariello, Francesca, Anzuini, Alessandra, Caffarra, Paolo, Barocco, Federica, Spallazzi, Marco, Paolo, Ceda Gian, Simonetta, Morganti, Andrea, Artoni, Chioatto, Paolo, Bortolamei, Sandra, Soattin, Lucia, Ruotolo, Giovanni, Beneamino, Borelli, Giuseppe, Barilaro, Bertazzoli, Marco, Rota, Elisabetta, Adobati, Annamaria, Scarpa, Alberto, Granziera, Serena, Zuccher, Paola, Fabbro, Angela Dal, Zara, Daniela, Lo Nigro, Ambra, Franchetti, Lorena, Toniolo, Marika, Marcuzzo, Cinzia, Rollone, Marco, Guerriero, Fabio, Sgarlata, Carmelo, Massè, Alessandro, Zatti, Giovanni, Piatti, Massimiliano, Graci, Jole, Benati, Giuseppe, Boschi, Federica, Biondi, Mario, Fiumi, Nicoletta, Erika, Tamburini, Locatelli, Sergio Mario, Mauri, Sabrina, Beretta, Mauro, Margheritis, Laura, Desideri, Giovanbattista, Liberatore, Ester, Carucci, Anna Cecilia, Bonino, Paolo, Caput, Margherita, Antonietti, Maria Paola, Polistena, Giuseppe, De la Pierre, Franz, Mari, Marcello, Massignani, Paola, Tombesi, Fabio, Selvaggio, Fabio, Verbo, Brunella, Bodoni, Paolo, Marchionni, Niccolò, Mossello, Enrico, Sabatini, Tony, Mussio, Eleonora, Magni, Eugenio, Bianchetti, Angelo, Crucitti, Andrea, Titoldini, Giulia, Cossu, Beatrice, Fascendini, Sara, Licini, Cristina, Tomasoni, Angela, Calderazzo, Massimo, Daniela, Tropiano, Valentina, Laganà, Melotti, Rita Maria, Lilli, Albina, Buda, Simona, Adversi, Marco, Noro, Gabriele, Turco, Renato, Ubezio, M Chiara, Mantovani, Anna Roberta, Viola, Maria Cristina, Serrati, Carlo, Pretta, Stefano, Infante, Maria, Gentile, Simona, Morandi, Alessandro, D'Ambrosio, Viviana, Mazzanti, Paolo, Brambilla, Cristina, Sportelli, Silvia, Platto, Caterina, Faraci, Bianca, Quattrocchi, Daniela, Pernigotti, Luigi Maria, Pisu, Cristina, Sicuro, Francesca, Zagnoni, Piergiuseppe, Ghiglia, Stefania, Mosca, Massimiliano, Corazzin, Ileana, Deola, Mariangela, Biagini, Carlo Adriano, Bencini, Francesca, Cantini, Claudia, Tonon, Elisabetta, Pierinelli, Silvia, Onofrj, Marco, Thomas, Astrid, Filomena, Borbone, Bonanni, Laura, Gabriella, Cacchiò, Comi, Giancarlo, Magnani, Giuseppe, Santangelo, Roberto, Mazzeo, Salvatore, Giuseppe, Magnani, Francesca, Caso, Giordano, Cecchetti, Roberto, Sant'Angelo, Barbieri, Cristina, Giroldi, Liviana, Bandini, Fabio, Masina, Marco, Malservisi, Simona, Cicognani, Annalena, Ricca, Laura, Piccininni, Maristella, Tassinari, Tiziana, Brogi, Davide, Sugo, Annalisa, Alessandra, Filippi, Sonia, Manfredi, Valerio, Vanni, Andrea, Usai Carlo, Enrico, Colombo, Vera, Renna Francesca, Assunta, Sauchella, Gianmaria, Zavarise, Mauro, Prete, Pietro, Bisagni, Roberto, Masini, Salvatore, Carrabetta, Barone, Antonella, Razzano, Monica, Giuseppe, Imperoli, Angela, Bini, Francesco, Serra, Valeria, D'Agostino, Federico, Gianolla, Lucia, Pietrangeli, Antonella, Velardi, Elisabetta, Di Cello, Cristina, Rosati, Nadia, Casali, Maria, Sessa, Luciano, Abruzzi, Chiara, Costanzi, Bini, Paolo, Pignata, Michele, Enrico, Buonagurio, Maria, Vollery, Giovanni, Carrieri, Giorgio, Cioni, Andrea, Toschi, Marco, Metra, Piera, Ranieri, Alberto, Zucchelli, Ceccon, Anna, Magrin, Laura, Marin, Sara, Barbara, Sofia, Marco, Masina, Laura, Ghedini, Matteo, Moroni, Marco, Paragona, Caterina, Pallotti Maria, Carla, Rota, Federica, Gottardi, Clara, Tomasoni, Melania, Cappuccio, Giampaolo, Bonini, Stefano, Guerini, Valeria, Guerini, Lucia, Merla, Giovambattista, Desideri, Ester, Liberatore, Cecilia, Carucci Anna, Maurizio, Tovaglieri, Vera, Renna Frandesca, Nadia, Bongiorni, Grillo, Antonio, Arenare, Francesca, Tonino, Mineo, David, Kanah, Giorgio, Vianello Piero, Ubaldo, Balducci, Vincenzo, Sidoti, Stefano, Montanari, Marino, Formilan, Busonera Flavio, Murelli Teodolindo, Paolo, Albanese, Monica, Maselli, Francesco, Bolzetta, Roberto, Fabris, Paolo, Bonino, DuranteMangoni, Emanuele, Testoni, Michela, Fabio, Di Stefano, Loredana, Seccia, Valeria, Sonzini, Fabiano, Maria, Annabella, Di Giorgio, Salvatore, De Cosmo, Greco, Antonio, Grazia, D'Onofrio, Daniele, Sancarlo, Gianluca, Resta, Renzo, Girardello, Sergio, Minervini, Morena, Boni, Vitali, Mariagrazia, Marina, Pizzoni, Paolo, De Colle, Cristina, Scarpa, Alessandra, Frattola, Orlandini, Francesco, La Regina, Micaela, Desirée, Addesi, Mirella, Filippo, Mario, Bo, Paola, Porrino, Padulo, Filomena, Cristina, Margheriti, Dario, Rolano, Giancarla, Moscatelli, Guido, Radaelli, Elena, Montini, Prete, Cosimo, Marileda, Novello, Igor, Bramuzzo, Nicole, Bertin, Elena, Rinaldo, Paolillo, Ciro, Riccardi, Angela, Claudia, Benedetti, Barbara, Rizzi, Francesca, Montagna, Silvia, Vitali, Chiara, Cutaia, Oliver, Baca, Mauro, Colombo, Eleonora, Marelli, Giuseppe, Procino, Rosaria, Tararà, Maria, Cottino, Davide, Dell'Acqua, Stefania, Cislaghi, Marco, Cairati, Massimo, Porta, Luca, Scaglione, Martina, De Feo, Paola, Vertolli, Lia, Salvati, Sandro, Cinotti, Valentina, De Santis, Erminia, Biferi, Paola, Cheli, Romina, Rebizzo, Minisola, Salvatore, Luciano, Colangelo, Pasquale, Abete, Ilaria, Liguori, Francesca, Curcio, Guglielmo, Spassini, Marco, Engheben, Sara, Rotunno, Paola, Arosio, Claudio, Angelini, Francesco, Reggiani, Alessandro, Cappelli, Simona, Marcheselli, Lara, Fratticci, Paola, Ranzani, Simonetta, Cesarini, Antonella, Cerini, Generoso, Uomo, Fernando, Gallucci, Giuliano, Ceschia, Emanuela, Serra, Mariolina, Sola, Alessandro, Delitala, Chiara, Pes, Giulia, Lobianco, Alessandro, Giani, Famularo, Simone, Sandini, Marta, Pinotti, Enrico, Gianotti, Luca, Antonella, Battuello, Giulia, Pintore, Sante, Giardini, Rossi, Andrea, Rubele, Sofia, Sant, Selena, Marco, Vignati, Danila, Clerici, Fabio, Rosa, Bandirali, Maria Pia, Nicoletta, Cattaneo, Laura, Boffi, Paolo, Tosoni, Luciano, Terranova, Leonello, Avalli, Margherita, Scanziani, Stefania, De Notaris, Pierluigi, Del Santo, Laura, Rossi, Fabiana, Tezza, Giovanna, Cervati, Antonino, Andreolli, Felice, Catalano, Giuseppe, Burattin, Danilo, Fogli, Giovanna, Di Bella, Francesco, Landi, Salini, Sara, Angela, Brunetti Maria, Giorgetta, Cappa, Giovanni, Galvagno, Paola, Cena, Gerardo, Bruno, Silvio, Raspo, Letizia, Semeraro, Sabrina, Pedrotti, Davide, Barra, Rosaria, Rizzo Maria, Maria, Dalise Anna, Raffaele, Prestano, Palmieri, Vincenzo Ostilio, Palasciano, Giuseppe, Belfiore, Anna, Portincasa, Piero, Carlo, Sabbà, Vincenzo, Solfrizzi, Alessia, D'introno, Valiani, Vincenzo, Carolina, Bologna, Tiziana, Ciarambino, Paola, Turelli, Ugo, Pazzaglia, Federica, Rodella, Giacomo, Piana, Castellano, Maurizio, Anna, Garelli, Elisa, Casella, Federica, Campana, Antonietta, Coschignano Maria, Luigi, Marinangeli, Fabio, Lorico, Salvatore, Bazzano, Giuseppe, Menculini, Gelosa, Giorgio, Viviana, Ambrogio Teresa, Piras, Valentina, Andrea, Ciricugno, Alessandra, Bollari, Coen, Daniele, Magliola, Renata, Milanesio, Deborah, Muzzulini, Carlo Lorenzo, Paolo, Fogliacco, Marinella, Turla, Sofia, Cotelli Maria, Marta, Bianchi, Siano, Pietro, Capo, Giuseppe, Napoletano, Rosa, Cecilia, Politi, Mancini, Concetta, Del Buono, Corrado, De Bartolomeo, Giuseppe, Addolorata, Martinelli, Carmen, Cefalogli, Roberto, Cozzi, Giovanni, Virtuani Angelo, Moschettini, Gianfilippo, Franco, Mastroianni, Daniela, Roglia, D'Amico, Gabriella, Mirella, Palella, Endrizzi, Cristina, Trotta, Lucia, Ciarambino, Tiziana, Orazio, Zanetti, Emanuela, Terazzi, Marta, Sacchetti, Thomas, Fleetwood, Giacomo, Tondo, Ignazio, Di Fazio, Andrea, Bruni, Giuseppe, Orsitto, Emanuela, Fabbro, Serena, Amici, Elena, D'Imporzano, Anna, Casanova, Serena, Bertolio, Erika, Nervo, Roberto, Silvestri, Elena, Semproni, Manuela, Pintus, Francesca, Aloe, Angelo, Tagliaccica, Zambon, Antonella, and Di Santo, Simona G.

Published
2020
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9. Innovation Strategy as Project Portfolio Management

Author

Marco Cantamessa and Francesca Montagna

Subjects
Resource (project management), OPM3, Knowledge management, business.industry, Application portfolio management, Innovation management, IT portfolio management, Business, Project management, Project portfolio management, Project management triangle
Abstract

This chapter provides a complementary view of innovation strategy to the one that has been developed in Chap. 8. Still following the resource-based view of the firm, we will concentrate on the decisions pertaining to which projects and activities should be performed, given the competencies the firm currently possesses, and the ones that it wishes to develop.

Published
2023
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12. Business Model Innovation

Author

Marco Cantamessa and Francesca Montagna

Subjects
Process management, Artifact-centric business process model, Management science, New business development, Computer science, Business analysis, Business architecture, Product-service system, Business model, Business transformation, Open innovation
Abstract

This chapter focuses on the emerging topic of business model innovation. The concept has already been mentioned in the previous chapters, and specifically in Chap. 1, during a preliminary discussion on different types of innovations, and then in Chap. 6, when introducing the concept of “Blue Ocean” strategy. Nevertheless, given its growing relevance in the field of innovation strategy, it is appropriate to dedicate a separate chapter to the topic. The subject will be discussed at first by providing some basic information and definitions, and then by exploring in depth two approaches that can be practically used to analyze and design business models.

Published
2023
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13. The Dynamics of Innovation

Author

Francesca Montagna and Marco Cantamessa

Subjects
Product lifecycle, Dynamics (music), Revolutionary change, Disruptive innovation, Business, Vertical integration, Product architecture, Industrial organization, Business model innovation
Abstract

The previous chapter has focused on the different types of innovation, mostly contrasting the extremes of evolutionary and revolutionary change.

Published
2023
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14. From Market Research to Product Positioning

Author

Marco Cantamessa and Francesca Montagna

Subjects
Reservation price, Market research, Process management, Work (electrical), business.industry, Process (engineering), Purchasing process, New product development, Product (category theory), Market share, Marketing, business
Abstract

Starting with this chapter, we make a deep plunge in the product development process with a very practical approach, exploring methods and tools that may support development teams in their work. The coverage of the development process will be limited to the first phases, at least up to the point where general-purpose methods can be applied, irrespectively of the industry and of the technology that underlies products or services. The subsequent phases of product development, which focus on the detailed design of products and processes and on product industrialization, will therefore be left aside.

Published
2023
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15. Fundamentals of Technology Forecasting

Author

Marco Cantamessa and Francesca Montagna

Subjects
Perspective (graphical), Sociology, Technology forecasting, Epistemology
Abstract

The previous chapters have looked at innovative phenomena from the privileged perspective of the management scholar, commenting on history after the facts have unfolded, trying to come up with rational explanations and to find recurrent patterns in s-curves and similar representations.

Published
2023
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16. Specifying the Product

Author

Francesca Montagna and Marco Cantamessa

Subjects
Product design specification, Front and back ends, Process management, Market segmentation, Computer science, business.industry, Perspective (graphical), New product development, Product (category theory), business, User requirements document, Quality function deployment
Abstract

Chapter 13 led us into the “front end” of the product development process, with a perspective that focused on the market. Readers should have left that chapter understanding how firms can interpret market needs and come up with a concise description of the product and of the market segment to address.

Published
2023
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17. Organizing Product Development Activities

Author

Marco Cantamessa and Francesca Montagna

Subjects
Organizational architecture, Focus (computing), Knowledge management, business.industry, Business process, media_common.quotation_subject, Perspective (graphical), New product development, Ignorance, Applied research, business, Human resources, media_common
Abstract

With this chapter, we depart from the high-level and strategic perspective that has characterized the discussion up to the previous chapter, and start delving deeper into the operational aspects of managing innovation and product development activities. In doing so, we will consider the organization of applied research and product development projects together, not in the ignorance of the differences existing between these two fields, but because the managerial challenges that characterize them make them nonetheless quite close to one another. This chapter will deal with organizational aspects and focus on human resources, while the following Chap. 11 will view such activities as business processes.

Published
2023
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20. Homologous or heterologous administration of mRNA or adenovirus-vectored vaccines show comparable immunogenicity and effectiveness against the SARS-CoV-2 Omicron variant

Author

Gabiria Pastore, Jacopo Polvere, Fabio Fiorino, Simone Lucchesi, Giorgio Montesi, Ilaria Rancan, Sara Zirpoli, Arianna Lippi, Miriam Durante, Massimiliano Fabbiani, Mario Tumbarello, Francesca Montagnani, Donata Medaglini, and Annalisa Ciabattini

Subjects
COVID-19 vaccination, heterologous and homologous vaccination, prime-boost, SARS-CoV-2, vaccination strategies, Internal medicine, RC31-1245
Abstract

ABSTRACTBackground Heterologous prime-boost schedules have been employed in SARS-CoV-2 vaccination, yet additional data on immunogenicity and effectiveness are still needed.Research design and methods Here, we measured the immunogenicity and effectiveness in the real-world setting of the mRNA booster dose in 181 subjects who had completed primary vaccination with ChAdOx1, BNT162b2, or mRNA1273 vaccines (IMMUNO_COV study; protocol code 18,869). The spike-specific antibody and B cell responses were analyzed up to 6 months after boosting.Results After an initial slower antibody response, the heterologous ChAdOx1/mRNA prime-boost formulation elicited spike-specific IgG titers comparable to homologous approaches, while spike-specific B cells showed a higher percentage of CD21−CD27− atypical cells compared to homologous mRNA vaccination. Mixed combinations of BNT162b2 and mRNA-1273 elicited an immune response comparable with homologous strategies. Non-significant differences in the Relative Risk of infection, calculated over a period of 18 months after boosting, were reported among homologous or heterologous vaccination groups, indicating a comparable relative vaccine effectiveness.Conclusions Our data endorse the heterologous booster vaccination with mRNA as a valuable alternative to homologous schedules. This approach can serve as a solution in instances of formulation shortages and contribute to enhancing vaccine strategies for potential epidemics or pandemics.

Published
2024
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21. Beyond alpha-band: The neural correlate of creative thinking

Author

Alessandro Mazza, Olga Dal Monte, Selene Schintu, Samuele Colombo, Nicola Michielli, Pietro Sarasso, Peter Törlind, Marco Cantamessa, Francesca Montagna, and Raffaella Ricci

Subjects
Creativity, Behavioral Neuroscience, Gamma band, Alpha band, Beta band, Cognitive Neuroscience, Divergent thinking, Eye-tracker, Experimental and Cognitive Psychology
Abstract

The compound nature of creativity entails the interplay of multiple cognitive processes, making it difficult to attribute creativity to a single neural signature. Divergent thinking paradigms, widely adopted to investigate creative production, have highlighted the key role of specific mental operations subserving creativity, such as inhibition of external stimuli, loose semantic associations, and mental imagery. Neurophysiological studies have typically shown a high alpha rhythm synchronization when individuals are engaged in creative ideation. Also, oculomotor activity and pupil diameter have been proposed as useful indicators of mental operations involved in such a thinking process. The goal of this study was to investigate whether beyond alpha-band activity other higher frequency bands, such as beta and gamma, may subserve divergent and convergent thinking and whether those could be associated with a different gaze bias and pupil response during ideas generation. Implementing a within-subjects design we collected behavioral measures, neural activity, gaze patterns, and pupil dilation while participants performed a revised version of the Alternative Uses Task, in which divergent thinking is contrasted to convergent thinking. As expected, participants took longer to generate creative ideas as compared to common ones. Interestingly, during divergent thinking participants displayed alpha synchronization along with beta and gamma desynchronization, more pronounced leftward gaze shift, and greater pupil dilation. During convergent thinking, an opposite pattern was observed: desynchronization in alpha and an increase in beta and gamma rhythm, along with a reduction of leftward gaze shift and greater pupil constriction. The present study uncovered specific neural dynamics and physiological patterns during idea generation, providing novel insight into the complex physiological signature of creative production.

Published
2022

22. SPEED OF DIFFUSION, RETHINKING TIME AND FIRMS’ STRATEGY: ANALYSIS OF THE INTERACTIONS TO LEAP ACROSS THE CHASM

Author

Francesca Montagna, Marco Cantamessa, and Alessandro Casagrande-Seretti

Subjects
time to market, business.industry, Strategy and Management, Time to market, First mover, Bass model, Strategy analysis, product development, adoption, Management of Technology and Innovation, New product development, Economics, First-mover advantage, Business and International Management, Diffusion (business), business, Industrial organization
Abstract

Although the literature has recognised short time to market and early entry as relevant factors, they are not enough alone to ensure success. In fact, an early entrant may successfully serve early adopters, but then fail in developing products suitable for those who adopt later (i.e., the early majority), dissipating the first-mover advantages previously gained. This paper argues that the likelihood of being successful in the early majority segment depends also on the rethinking time, defined as the time available to firms serving early adopters for planning and developing products that will be offered to the upcoming early majority segment. The rethinking time is here analytically defined through the Bass model and its relationship with product success is investigated. The paper shows that the market leader in the early majority segment is expected to be the incumbent when rapid diffusion occurs and, conversely, new entrants when rethinking time is longer.

Published
2021
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23. Management of Innovation and Product Development : Integrating Business and Technological Perspectives

Author

Marco Cantamessa, Francesca Montagna, Marco Cantamessa, and Francesca Montagna

Subjects
Product design, Technological innovations--Management
Abstract

This textbook provides a unique and original understanding on innovation and on product design and development, and on their tight interconnections. It presents an integrated and holistic perspective on these two fields, allowing readers to understand how the phenomenon of innovation occurs – and must be managed – at different and interacting levels, from corporate strategy to design decision-making.This book explores these themes in a scientifically rigorous manner, associating academic findings with examples from business. It provides readers with the conceptual and decision-making tools required to understand and manage the process of innovation at different levels, from the analysis of industry-wide phenomena to the formulation of a strategy, and from the planning of operations to the management of technical choices. Chapters cover innovation as an economic and social phenomenon, the formulation of innovation strategy, the management of product development processes and projects and the technical design of products and services. Offering an invaluable resource to postgraduate students in economics, management and engineering, this book is also intended for managers and entrepreneurs.The book's topics are covered by associating academic findings with examples from business. For this new second edition of the book, case studies are made available through a companion LinkedIn page that is continuously updated by authors and by readers, while pointers to complementary content available on the internet are provided throughout the text.

Published
2023

24. Design computing and cognition

Author

Francesca Montagna and Gaetano Cascini

Subjects
Cognitive science, Engineering, Artificial Intelligence, business.industry, Cognition, business, Industrial and Manufacturing Engineering
Published
2020

25. Consumer sensitivity to delivery lead time: a furniture retail case

Author

Gaetano Marino, Francesca Montagna, and Giulio Zotteri

Subjects
Delivery lead time, Logit model, Consumer intertemporal choice, Operations management, Inventory management, Furniture retail, Supply chain management, Supply chain, 05 social sciences, Delivery lead time, Service management, Transportation, Inventory management, Consumer intertemporal choice, Intertemporal choice, Marketing mix, Purchasing, Operations management, Management of Technology and Innovation, Logit model, 0502 economics and business, Value (economics), 050211 marketing, Business, Marketing, Furniture retail, 050203 business & management, Lead time
Abstract

Purpose Short delivery time is a feature that can influence consumers’ purchasing decisions and that retailers compete over fiercely. Accordingly, evaluating the effect of delivery time on demand and identifying marketing-mix variables that alter this relationship may influence retailers’ strategies and impact supply chain (SC) performance. The paper aims to discuss these issues. Design/methodology/approach This study was performed in collaboration with the largest furniture retailer in Italy, which provided its sales and inventory data for 19,000 units sold over a six-month period in 32 stores throughout Italy. Data were analysed using logistic regression with fixed effects. Findings The value of delivery time for consumers, even in an industry generally characterised by long delivery lead times, is surprisingly high. The evidence reveals that when the delivery time changes from two days to seven days, demand is reduced by 37.5 per cent, although variables related to location and the marketing mix moderate this relationship. Practical implications Retailers can use the findings presented herein to drive their inventory and facility planning decisions and support investments in SC integration. Originality/value Supply chain management (SCM) studies consider the value of delivery time anecdotally and have neglected empirical estimations of the magnitude of the effects of delivery time on consumer demand. Further, SCM studies have not explored the factors moderating this relationship, although intertemporal choice and service management studies have demonstrated the existence of such factors.

Published
2018
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26. Host genetics and COVID-19 severity: increasing the accuracy of latest severity scores by Boolean quantum features

Author

Gabriele Martelloni, Alessio Turchi, Chiara Fallerini, Andrea Degl’Innocenti, Margherita Baldassarri, Simona Olmi, Simone Furini, Alessandra Renieri, GEN-COVID Multicenter study, Francesca Mari, Sergio Daga, Ilaria Meloni, Mirella Bruttini, Susanna Croci, Mirjam Lista, Debora Maffeo, Elena Pasquinelli, Giulia Brunelli, Kristina Zguro, Viola Bianca Serio, Enrica Antolini, Simona Letizia Basso, Samantha Minetto, Giulia Rollo, Martina Rozza, Angela Rina, Rossella Tita, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Francesca Ariani, Francesca Montagnani, Mario Tumbarello, Ilaria Rancan, Massimiliano Fabbiani, Elena Bargagli, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Federico Franchi, Maria Antonietta Mazzei, Susanna Guerrini, Edoardo Conticini, Luca Cantarini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli Raffaelli, Arianna Emiliozzi, Marco Feri, Alice Donati, Raffaele Scala, Luca Guidelli, Genni Spargi, Marta Corridi, Cesira Nencioni, Leonardo Croci, Gian Piero Caldarelli, Davide Romani, Paolo Piacentini, Maria Bandini, Elena Desanctis, Silvia Cappelli, Anna Canaccini, Agnese Verzuri, Valentina Anemoli, Manola Pisani, Agostino Ognibene, Maria Lorubbio, Alessandro Pancrazzi, Massimo Vaghi, Antonella D’Arminio Monforte, Federica Gaia Miraglia, Mario U. Mondelli, Stefania Mantovani, Raffaele Bruno, Marco Vecchia, Marcello Maffezzoni, Enrico Martinelli, Massimo Girardis, Stefano Busani, Sophie Venturelli, Andrea Cossarizza, Andrea Antinori, Alessandra Vergori, Stefano Rusconi, Matteo Siano, Arianna Gabrieli, Agostino Riva, Daniela Francisci, Elisabetta Schiaroli, Carlo Pallotto, Saverio Giuseppe Parisi, Monica Basso, Sandro Panese, Stefano Baratti, Pier Giorgio Scotton, Francesca Andretta, Mario Giobbia, Renzo Scaggiante, Francesca Gatti, Francesco Castelli, Eugenia Quiros-Roldan, Melania Degli Antoni, Isabella Zanella, Matteo della Monica, Carmelo Piscopo, Mario Capasso, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Giuseppe Fiorentino, Massimo Carella, Marco Castori, Giuseppe Merla, Gabriella Maria Squeo, Filippo Aucella, Pamela Raggi, Rita Perna, Matteo Bassetti, Antonio Di Biagio, Maurizio Sanguinetti, Luca Masucci, Alessandra Guarnaccia, Serafina Valente, Alex Di Florio, Marco Mandalà, Alessia Giorli, Lorenzo Salerni, Patrizia Zucchi, Pierpaolo Parravicini, Elisabetta Menatti, Tullio Trotta, Ferdinando Giannattasio, Gabriella Coiro, Fabio Lena, Gianluca Lacerenza, Cristina Mussini, Luisa Tavecchia, Lia Crotti, Gianfranco Parati, Roberto Menè, Maurizio Sanarico, Marco Gori, Francesco Raimondi, Alessandra Stella, Filippo Biscarini, Tiziana Bachetti, Maria Teresa La Rovere, Maurizio Bussotti, Serena Ludovisi, Katia Capitani, Simona Dei, Sabrina Ravaglia, Annarita Giliberti, Giulia Gori, Rosangela Artuso, Elena Andreucci, Angelica Pagliazzi, Erika Fiorentini, Antonio Perrella, Francesco Bianchi, Paola Bergomi, Emanuele Catena, Riccardo Colombo, Sauro Luchi, Giovanna Morelli, Paola Petrocelli, Sarah Iacopini, Sara Modica, Silvia Baroni, Giulia Micheli, Marco Falcone, Donato Urso, Giusy Tiseo, Tommaso Matucci, Davide Grassi, Claudio Ferri, Franco Marinangeli, Francesco Brancati, Antonella Vincenti, Valentina Borgo, Stefania Lombardi, Mirco Lenzi, Massimo Antonio Di Pietro, Francesca Vichi, Benedetta Romanin, Letizia Attala, Cecilia Costa, Andrea Gabbuti, Alessio Bellucci, Marta Colaneri, Patrizia Casprini, Cristoforo Pomara, Massimiliano Esposito, Roberto Leoncini, Michele Cirianni, Lucrezia Galasso, Marco Antonio Bellini, Chiara Gabbi, and Nicola Picchiotti

Subjects
COVID-19, host genetics, integrated polygenic score, genetic algorithm, logistic regression, genetic science modeling, Genetics, QH426-470
Abstract

The impact of common and rare variants in COVID-19 host genetics has been widely studied. In particular, in Fallerini et al. (Human genetics, 2022, 141, 147–173), common and rare variants were used to define an interpretable machine learning model for predicting COVID-19 severity. First, variants were converted into sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. After that, the Boolean features, selected by these logistic models, were combined into an Integrated PolyGenic Score (IPGS), which offers a very simple description of the contribution of host genetics in COVID-19 severity.. IPGS leads to an accuracy of 55%–60% on different cohorts, and, after a logistic regression with both IPGS and age as inputs, it leads to an accuracy of 75%. The goal of this paper is to improve the previous results, using not only the most informative Boolean features with respect to the genetic bases of severity but also the information on host organs involved in the disease. In this study, we generalize the IPGS adding a statistical weight for each organ, through the transformation of Boolean features into “Boolean quantum features,” inspired by quantum mechanics. The organ coefficients were set via the application of the genetic algorithm PyGAD, and, after that, we defined two new integrated polygenic scores (IPGSph1 and IPGSph2). By applying a logistic regression with both IPGS, (IPGSph2 (or indifferently IPGSph1) and age as inputs, we reached an accuracy of 84%–86%, thus improving the results previously shown in Fallerini et al. (Human genetics, 2022, 141, 147–173) by a factor of 10%.

Published
2024
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27. Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

Author

Morandi, Alessandro, primary, Zambon, Antonella, additional, Di Santo, Simona G., additional, Mazzone, Andrea, additional, Cherubini, Antonio, additional, Mossello, Enrico, additional, Bo, Mario, additional, Marengoni, Alessandra, additional, Bellelli, Giuseppe, additional, Rispoli, Vincenzo, additional, Malara, Alba, additional, Spadea, Fausto, additional, Di Cello, Serena, additional, Ceravolo, Francesco, additional, Fabiano, Francesco, additional, Chiaradia, Giuseppe, additional, Gabriele, Amedeo, additional, Lenino, Peluso, additional, Andrea, Taristano, additional, Settembrini, Vincenzo, additional, Capomolla, Domenico, additional, Citrino, Antonella, additional, Scriva, Antonietta, additional, Bruno, Irene, additional, Secchi, Roberto, additional, De Martino, Eugenio, additional, Muccinelli, Roberto, additional, Lupi, Gerardo, additional, Paonessa, Patrizio, additional, Fabbri, Andrea, additional, Passuti, Maria Teresa, additional, Castellari, Sofia, additional, Po, Andrea, additional, Gaggioli, Guido, additional, Varesi, Massimo, additional, Moneti, Paolo, additional, Capurso, Sebastiano, additional, Latini, Vincenzo, additional, Ghidotti, Stefano, additional, Riccardelli, Francesco, additional, Macchi, Maurizio, additional, Rigo, Rosaria, additional, Claudio, Pascale, additional, Angelo, Bosio, additional, Flavio, Cerrato, additional, Benedetta, Bardelli, additional, Boffelli, Stefano, additional, Cassinadri, Angela, additional, Franzoni, Simone, additional, Spazzini, Elena, additional, Andretto, Daniela, additional, Tonini, Gabriele, additional, Andreani, Laura, additional, Coralli, Mirco, additional, Balotta, Antonio, additional, Cancelliere, Roberto, additional, Ballardini, Giorgio, additional, Simoncelli, Margherita, additional, Mancini, Annarita, additional, Strazzacapa, Mara, additional, Fabio, Stefano, additional, De Filippi, Francesco, additional, Giudice, Chiara, additional, Dentizzi, Cosimo, additional, Azzini, Margherita, additional, Cazzadori, Marco, additional, Mastroeni, Valeria, additional, Bertassello, Paolo, additional, Claudia Benati, Helena Santana, additional, Nesta, Elisa, additional, Tobaldini, Chiara, additional, Guerini, Fabio, additional, Elena, Tambara, additional, Mombelloni, Paolo, additional, Fontanini, Fulvio, additional, Gabriella, Lassa, additional, Pizzorni, Crosio, additional, Oliverio, Martina, additional, Del Grosso, Luciano Luca, additional, Giavedoni, Cristina, additional, Bidoli, Giuliano, additional, Mazzei, Bruno, additional, Corsonello, Andrea, additional, Fusco, Sergio, additional, Vena, Silvio, additional, De Vuono, Tommaso, additional, Maiuri, Giorgio, additional, Luca, Fimognari Filippo, additional, Andrea, Arone, additional, Giovanni, Sgrò, additional, Rossella, Nicolazzo, additional, Castegnaro, Eugenio, additional, De Rosa, Salvatore, additional, Sechi, Rossella Bazzano, additional, Benvenuti, Enrico, additional, Del Lungo, Ilaria, additional, Giardini, Sante, additional, Giulietti, Chiara, additional, Mauro, Di Bari, additional, Eleonora, Barghini, additional, Martina, Paoli, additional, Irene, Fiordelli, additional, Riccardo, Barucci, additional, Federica, Sgrilli, additional, Ilaria, Del Lungo, additional, Bertoletti, Erik, additional, D'Amico, Ferdinando, additional, Caronzolo, Francesco, additional, Grippa, Alessandro, additional, Lombardo, Giuseppina, additional, Pipicella, Tiziana, additional, Antonino, Saitta, additional, Francesco, Corica, additional, Valeria, Prestipino Giarritta, additional, Daniela, Larosa, additional, Domenico, Cucinotta, additional, Giorgio, Basile, additional, March, Albert, additional, Nitti, Maria Teresa, additional, Felici, Alessandro, additional, Pavan, Silvia, additional, Piazzani, Fabrizio, additional, Lunelli, Alessandra, additional, Dimori, Sergio, additional, Margotta, Alessandro, additional, Soglia, Tiziano, additional, Postacchini, Demetrio, additional, Brunelli, Roberto, additional, Santini, Silvia, additional, Francavilla, Monia, additional, Macchiati, Ilenia, additional, Sorvillo, Francesca, additional, Giuli, Cinzia, additional, Mecocci, Patrizia, additional, Longo, Annalisa, additional, Perticone, Francesco, additional, Addesi, Desireè, additional, Rosa, Paola Cerra, additional, Bencardino, Giuseppe, additional, Falbo, Tania, additional, Grillo, Nadia, additional, Marco, Filice, additional, Mirella, Flippo, additional, Fantò, Fausto, additional, Isaia, Gianluca, additional, Pezzilli, Stella, additional, Bergamo, Daniele, additional, Furno, Elisabetta, additional, Rrodhe, Sokol, additional, Lucarini, Simonetta, additional, Dijk, Babette, additional, Dall'Acqua, Francesca, additional, Cappelletto, Francesco, additional, Calvani, Donatella, additional, Becheri, Dimitri, additional, Giuseppe, Mottino, additional, Costanza, Mitidieri, additional, Vito, Antonio, additional, Francesca, Bartalucci, additional, Magherini, Lorenza, additional, Novella, Malin, additional, Franca, Boni, additional, Lucia Gambardella, Paoli Martina, additional, Valente, Carlo, additional, Ilaria, Bracali, additional, Alice, Foschini, additional, Porrino, Paola, additional, Ceci, Giacomo, additional, Giuliana, Bottignole, additional, Michela, Tibaldi, additional, Eleonora, Coppo, additional, Ettore, Evaristo, additional, Camellini, Cinzia, additional, Servello, Adriana, additional, Grassi, Alessandro, additional, Rozzini, Renzo, additional, Tironi, Sara, additional, Grassi, Maria Grazia, additional, Troisi, Elio, additional, Carlo, Caltagirone, additional, Simona Gabriella, Di Santo, additional, Flaminia, Franchini, additional, Federica, Ratto, additional, Beatrice, Pavoni, additional, Sofia, Toniolo, additional, Gabutto, Anna, additional, Quazzo, Loredana, additional, Rosatello, Annalisa, additional, Suraci, Domenico, additional, Tagliabue, Benedetta, additional, Perrone, Chiara, additional, Ferrara, Lucia, additional, Castagna, Alberto, additional, Tremolada, Maria Luisa, additional, Giuseppe, Castoldi, additional, Stefano, Barbero, additional, Davide, Oltramonti, additional, Piano, Simonetta, additional, Serviddio, Gaetano, additional, Lo Buglio, Aurelio, additional, Gurrera, Tiziana, additional, Merlo, Valeria, additional, Rovai, Carla, additional, Cotroneo, Antonino Maria, additional, Carlucci, Rosaria, additional, Abbaldo, Anna, additional, Monzani, Fabio, additional, Qasem, Ahmad Amedeo, additional, Bini, Giacomo, additional, Tafuto, Silvia, additional, Galli, Giovanni, additional, Bruni, Amalia Cecilia, additional, Mancuso, Giovanna, additional, Mancuso, Gerardo, additional, Calipari, Daniela, additional, Giuseppe Massimiliano, De Luca, additional, Bernardini, Bruno, additional, Corsini, Carla, additional, Michele, Ciccarelli, additional, Sara, Dal Farra, additional, Cagnin, Annachiara, additional, Fragiacomo, Federica, additional, Pompanin, Sara, additional, Piero, Amodio, additional, Marco, Cagnin, additional, Zurlo, Amedeo, additional, Guerra, Gianluca, additional, Pala, Marco, additional, Menozzi, Luca, additional, Gatti, Chiara Delli, additional, Magon, Stefania, additional, Roberto, Manfredini, additional, Alfredo, De Giorgi, additional, Fabio, Fabbian, additional, Ruana, Tiseo, additional, Elisa, Misurati, additional, Benedetta, Boari, additional, Christian, Molino, additional, Marco, Pala, additional, Massimo, Gallerani, additional, Di Francesco, Vincenzo, additional, Faccioli, Silvia, additional, Pellizzari, Luca, additional, Giorgia, Fontana, additional, Barbagallo, Giuseppe, additional, Lunardelli, Maria Lia, additional, Martini, Emilio, additional, Ferrari, Eleonora, additional, Macchiarulo, Maria, additional, Corneli, Maria, additional, Bacci, Monica, additional, Battaglia, Giuseppe, additional, Anastasio, Luigi, additional, Lo Storto, Mario Sostene, additional, Seresin, Chiara, additional, Simonato, Matteo, additional, Loreggian, Michele, additional, Cestonaro, Fausta, additional, Durando, Mario, additional, Latella, Raffaele, additional, Mazzoleni, Marta, additional, Russo, Giuseppe, additional, Ponte, Martino, additional, Valchera, Alessandro, additional, Salustri, Giuseppe, additional, Petritola, Donatella, additional, Costa, Alfredo, additional, Sinforiani, Elena, additional, Cotta, Matteo Ramusino, additional, Pizio, Renato Nicola, additional, Cester, Alberto, additional, Formilan, Marino, additional, Pietro, Bonometto, additional, Carbone, Pasqualina, additional, Cazzaniga, Ilaria, additional, Appollonio, Ildebrando, additional, Cereda, Diletta, additional, Stabile, Andrea, additional, Xhani, Rubjona, additional, Acampora, Roberto, additional, Tremolizzo, Lucio, additional, Federico, Pieruzzi, additional, Antonio, Ciaccio, additional, Valerio, Pontecorvi, additional, Cesare, Burti, additional, Zhirajr, Mokini, additional, Giovanni, Vitale, additional, Maria, Amigoni, additional, Mariaelena, Sparacino, additional, Bottacchi, Edo, additional, Bucciantini, Elisabetta, additional, Di Giovanni, Marco, additional, Franchi, Fabrizio, additional, Lucchetti, Lucio, additional, Mariani, Claudio, additional, Grande, Giulia, additional, Rapazzini, Piero, additional, Marco, Mauri, additional, Romanelli, Giuseppe, additional, Franco, Nicosia, additional, Alessio, Margola, additional, Stefano, Bonardelli, additional, Nicola, Latronico, additional, Laura, Porcella, additional, Nazario, Portolani, additional, Carlo, Concoreggi, additional, Chiara, Grassini, additional, Soccorso, Pronto, additional, Andrea, Salvi, additional, Luca, Bianchetti, additional, Francesca, Spagnoli, additional, Roberto, Apuzzo, additional, Marco, Fontanella, additional, Anna, Ceraso, additional, Francesco, Castelli, additional, Fugazza, Luciano, additional, Guerrini, Chiara, additional, De Paduanis, Giovanna, additional, Iallonardo, Lucia, additional, Palumbo, Pasquale, additional, Zuliani, Giovanni, additional, Ortolani, Beatrice, additional, Capatti, Eleonora, additional, Soavi, Cecilia, additional, Bianchi, Lara, additional, Francesconi, Daniela, additional, Miselli, Agata, additional, Gloria, Brombo, additional, Tommaso, Romagnoli, additional, Chiara, Pazzaglini, additional, Agata, Miselli Maria, additional, Marco, Dall'Agata, additional, Luca, Menozzi, additional, Gianluca, Guerra, additional, Suardi, Teresa, additional, Zaccarini, Cinzia, additional, Manuela, Riva, additional, Mirra, Gianluca, additional, Muti, Ettore, additional, Bottura, Renato, additional, Gianpaolo, Moretti, additional, Secreto, Piero, additional, Bisio, Erika, additional, Cecchettani, Marco, additional, Naldi, Tamara, additional, Pallavicino, Alessandra, additional, Pugliese, Michela, additional, Iozzo, Rosaria Cosima, additional, Grassi, Guido, additional, Michele, Bombelli, additional, Raffaella, Dell'Oro, additional, Fosca, Quarti Trevano, additional, Giorgio, Giussani Carlo, additional, Giovanni, Paternò, additional, Ernesto, Contro, additional, Mannironi, Antonio, additional, Giorli, Elisa, additional, Oberti, Sara, additional, Fierro, Brigida, additional, Piccoli, Tommaso, additional, Giacalone, Fabio, additional, Mandas, Antonella, additional, Serchisu, Luca, additional, Costaggiu, Diego, additional, Pinna, Elisa, additional, Orrù, Francesca, additional, Mannai, Martina, additional, Cordioli, Zeno, additional, Pelizzari, Luca, additional, Turcato, Emanuela, additional, Arduini, Pietro, additional, Cacace, Carlo, additional, Chiloiro, Roberta, additional, Cimino, Rosella, additional, Ruberto, Carmen, additional, Giovanni, Ruotolo, additional, Pietro, Gareri, additional, Laura, Greco, additional, Alberto, Castagna, additional, Carmen, Ruberto, additional, Santo, Pierluigi Dal, additional, Andriolli, Antonino, additional, Burattin, Giuseppe, additional, Rossi, Laura, additional, Andreolli Antonino, Cervati Giovanna, additional, Giuseppe, Catalano, additional, Tezza, Fabiana, additional, Maddalena, Pizzardini, additional, Laura, Stievano, additional, Crippa, Patrizia, additional, Aloisio, Paola, additional, Di Monda, Tiziana, additional, Malighetti, Alessandro, additional, Galbassini, Gloria, additional, Salutis, Domus, additional, Ivaldi, Claudio, additional, Russo, Anna Maria, additional, Bennati, Ettore, additional, Pino, Elisabetta, additional, Zavarise, Gianmaria, additional, Pesci, Alberto, additional, Suigo, Giulia, additional, Faverio, Paola, additional, Andrea, Gori, additional, Sabrina, Perego, additional, Zanasi, Massimo, additional, Moniello, Giovanni, additional, Rostagno, Carlo, additional, Cartei, Alessandro, additional, Polidori, Gianluca, additional, Ungar, Andrea, additional, Melis, Maria Ramona, additional, Martellini, Eleonora, additional, Enrico, Mossello, additional, Monica, Torrini, additional, Antonella, Giordano, additional, Giovanna, Leone, additional, Migliorini, Marta, additional, Caramelli, Francesca, additional, Battiston, Bruno, additional, Berardino, Maurizio, additional, Cavallo, Simona, additional, Alessandro, Massè, additional, Anna, Santoro, additional, Lombardi, Bruna, additional, D'Ippolito, Pierpaolo, additional, Furini, Angela, additional, Villani, Daniele, additional, Clara, Raimondi, additional, Guarneri, Massimo, additional, Paolucci, Stefano, additional, Bassi, Andrea, additional, Coiro, Paola, additional, De Angelis, Domenico, additional, Morone, Giovanni, additional, Venturiero, Vincenzo, additional, Palleschi, Lorenzo, additional, Raganato, Paolo, additional, Di Niro, Giuseppina, additional, Rosa, Casini Anna, additional, Loredana, Bove, additional, Imoscopi, Alessandra, additional, Isaia, Giancarlo, additional, Tibaldi, V., additional, Bottignole G, G., additional, Calvi, E., additional, Clementi, C., additional, Zanocchi, M., additional, Agosta, L., additional, Nortarelli, Antonella, additional, Provenzano, Giuseppe, additional, Mari, Daniela, additional, Romano, Federica Ylenia, additional, Rosini, Francesca, additional, Mansi, Marta, additional, Rossi, Silvia, additional, Geriatria, Alex Riccardelli, additional, Inzaghi, Lorenzo, additional, Bonini, Giulia, additional, Rossi, Paolo, additional, Potena, Alfredo, additional, Lichii, Mihaela, additional, Candiani, Tiziana, additional, Grimaldi, William, additional, Bertani, Emiliano, additional, Alessandra, Porta, additional, Calogero, Pietro, additional, Pinto, Daniela, additional, Bernardi, Roberto, additional, Nicolino, Francesco, additional, Galetti, Caterina, additional, Gianstefani, Alice, additional, Giulia, Corvalli, additional, Lorenzo, Mulazzani, additional, Odetti, Patrizio, additional, Monacelli, Fiammetta, additional, Prefumo, Matteo, additional, Fiammetta, Monacelli, additional, Canepa, Marta, additional, Minaglia, Cecilia, additional, Paolisso, Giuseppe, additional, Rizzo, Maria Rosaria, additional, Prestano, Raffaele, additional, Dalise, Anna Maria, additional, Barra, Davide, additional, Bosco, Livio Dal, additional, Asprinio, Vincenzo, additional, Dallape, Luciana, additional, Perina, Elisa, additional, Incalzi, Raffaele Antonelli, additional, Bartoli, Isaura Rossi, additional, Pluderi, Alice, additional, Maina, Antonella, additional, Pecoraro, Elisabetta, additional, Sciarra, Michela, additional, Prudente, Angela, additional, Paola, Maina, additional, Francesca, Mete, additional, Manuel, Ventura, additional, Luisella, Cesari, additional, Maria, Pernigotti Luigi, additional, Tina, Santangelo, additional, Benini, Lucia, additional, Levato, Francesco, additional, Mhiuta, Victor, additional, Alius, Florin, additional, Davidoaia, Diana, additional, Giardini, Vittorio, additional, Garancini, Mattia, additional, Bellamoli, Claudio, additional, Terranova, Luciano, additional, Bozzini, Claudia, additional, Tosoni, Paolo, additional, Provoli, Emma, additional, Cascone, Luisa, additional, Dioli, Andrea, additional, Ferrarin, Gianfranco, additional, Bucci, Adelmo, additional, Bua, Guido, additional, Fenu, Sara, additional, Bianchi, Giovanna, additional, Casella, Silvia, additional, Romano, Valentina, additional, Maurizio, Poli, additional, Mascherona, Ilenia, additional, Belotti, Gloria, additional, Cavaliere, Sabina, additional, Cuni, Estella, additional, Merciuc, Nina, additional, Oberti, Rosella, additional, Veneziani, Silvia, additional, Capoferri, Emanuela, additional, De Bernardi, Elisabetta, additional, Colombo, Katia, additional, Bravi, Marco, additional, Nicoletta, Negrinotti, additional, D'Arcangelo, Paolo, additional, Montenegro, Nicola, additional, Montanari, Roberto, additional, Lamanna, Pierpaolo, additional, Gasperini, Beatrice, additional, Isabella, Montesi, additional, Stefania, Diotallevi, additional, Gaia, Altobelli, additional, Filippo, Calcinaro, additional, Palamà, Chiara, additional, Di Emidio, Chiara, additional, Scarpini, Elio, additional, Arighi, Andrea, additional, Fumagalli, Giorgio, additional, Basilico, Paola, additional, De Amicis Margherita, Migone, additional, Marta, Mancarella, additional, Diletta, Maira, additional, Granata, Antonino, additional, Ranalli, Claudia, additional, Cammilli, Alessandra, additional, Cavallini, Maria Chiara, additional, Tricca, Manola, additional, Natella, Daniela, additional, Gabbani, Luciano, additional, Tesi, Francesca, additional, Martella, Letizia, additional, Imbrici, Rosalba, additional, Guerrini, Gianbattista, additional, Scotuzzi, Anna Maria, additional, Sozzi, Ferdinando, additional, Valenti, Luigi, additional, Chiarello, Antonino, additional, Monia, Monella, additional, Pilotto, Alberto, additional, Prete, Camilla, additional, Senesi, Barbara, additional, Meta, Anna Cristina, additional, Pendenza, Enrico, additional, Pasqualetti, Giuseppe, additional, Polini, Antonio, additional, Tognini, Sara, additional, Ballino, Elena, additional, Dell'Aquila, Giuseppina, additional, Gasparrini, Pina Maria, additional, Marotti, Elisabetta, additional, Migale, Monica, additional, Scrimieri, Antonia, additional, Falsetti, Lorenzo, additional, Salvi, Aldo, additional, Toigo, Gabriele, additional, Ceschia, Giuliano, additional, Rosso, Alessia, additional, Tongiorgi, Chiara, additional, Scarpa, Cristina, additional, Maurizio, Pacchioni, additional, De Dominicis, Luigino, additional, Pucci, Eugenio, additional, Renzi, Sara, additional, Cartechini, Elisabetta, additional, Tomassini, Pia Francesca, additional, Del Gobbo, Maurizio, additional, Ugenti, Francesca, additional, Romeo, Pasquale, additional, Nardelli, Anna, additional, Lauretani, Fulvio, additional, Visioli, Sandra, additional, Montanari, Ilaria, additional, Ermini, Francesca, additional, Giordano, Antonio, additional, Pigato, Giorgio, additional, Simeone, Emilio, additional, Barbujani, Mario, additional, Giampieri, Marina, additional, Amoruso, Raffaele, additional, Piccinini, Maristella, additional, Ferrari, Camilla, additional, Gambetti, Claudio, additional, Sfrappini, Mario, additional, Semeraro, Letizia, additional, Striuli, Rinaldo, additional, Mariani, Claudia, additional, Pelliccioni, Giuseppe, additional, Marinelli, Donatella, additional, Fabi, Katia, additional, Rossi, Tommaso, additional, Pesallaccia, Martina, additional, Sabbatini, Debora, additional, Gobbi, Beatrice, additional, Cerqua, Raffaella, additional, Tagliani, Giancarla, additional, Schlauser, Elena, additional, Caser, Luciano, additional, Caramello, Elisa, additional, Sandigliano, Franca, additional, Rosso, Giorgio, additional, Ferrari, Alberto, additional, Bendini, Chiara, additional, Luisa, Davoli Maria, additional, Casella, Monica, additional, Prampolini, Raffaella, additional, Scevola, Moreno, additional, Vitale, Enrico, additional, Roberto, Brugiolo, additional, Carlo, Fagherazzi, additional, Sergio, Fusco, additional, Alberto, Scarpa, additional, Daniela, Zara, additional, Giulia, Bertozzo, additional, Serena, Granziera, additional, Michele, Barazzuol, additional, Maugeri, Domenico, additional, Sorace, Rosaria, additional, Anzaldi, Massimiliano, additional, De Gesu, Roberto, additional, Morrone, Giuseppe, additional, Davolio, Federica, additional, Fabbo, Andrea, additional, Palmieri, Marina, additional, Zoli, Marco, additional, Forti, Paola, additional, Pirazzoli, Luca, additional, Fabbri, Elisa, additional, Terenzi, Laura, additional, Bergolari, Federica, additional, Wenter, Christian, additional, Ruffini, Ingrid, additional, Insam, Miriam, additional, Abraham, Elisabeth, additional, Kirchlechner, Christine, additional, Cucinotta, Domenico, additional, Antonino, Lasco, additional, Basile, Giorgio, additional, Grazia, Arena Maria, additional, Parise, Pasquale, additional, Boccali, Andrea, additional, Amici, Serena, additional, Gambacorta, Maurizia, additional, Lasagni, Anna, additional, Lovati, Roberto, additional, Giovinazzo, Francesca, additional, Kimak, Elzbieta, additional, Zappa, Paolo, additional, Medici, Francesco, additional, Lo Castro, Marika, additional, Mauro, Flavia, additional, De Luca, Alessandro, additional, Sancesario, Giuseppe, additional, Martorana, Alessandro, additional, Scaricamazza, Beatrice, additional, Toniolo, Sofia, additional, Di Lorenzo, Francesco, additional, Liguori, Claudio, additional, Lasco, Antonino, additional, Vita, Natale, additional, Giomi, Mirna, additional, Forte, Floriana, additional, Padovani, Alessandro, additional, Rozzini, Luca, additional, Ceraso, Anna, additional, Salvatore, Caratozzolo, additional, Cottino, Maria, additional, Vitali, Silvia, additional, Marelli, Eleonora, additional, Tripi, Gabriele, additional, Miceli, Salvatore, additional, Urso, Giovanni, additional, Grioni, Giuseppe, additional, Vezzadini, Giuliana, additional, Misaggi, Giulia, additional, Forlani, Chiara, additional, Avanzi, Stefano, additional, Serena, Saulle, additional, Claudia, Casarini, additional, Marilena, Viggiano, additional, Alberto, Luisa, additional, Diego, Ghianda, additional, Alessandro, Giordano, additional, Iemolo, Francesco, additional, Giordano, Antonello, additional, Sanzaro, Enzo, additional, D'Asta, Gabriele, additional, Proietto, Maria, additional, Carnemolla, Anna, additional, Razza, Grazia, additional, Spadaro, Daniela, additional, Bertolotti, Marco, additional, Mussi, Chiara, additional, Neviani, Francesca, additional, Roberto, Chiesa, additional, Valentina, Guerzoni, additional, Linda, Morselli, additional, Francesca, Venturelli, additional, Tarozzi, Adriano, additional, Balestri, Francesca, additional, Mannarino, Giulio, additional, Bigolari, Michela, additional, Natale, Alessia, additional, Grassi, Simona, additional, Bottaro, Cinzia, additional, Stefanelli, Sara, additional, Bovone, Ugo, additional, Tortorolo, Umberto, additional, Quadri, Roberto, additional, Leone, Giuseppe, additional, Ponzetto, Maria, additional, Frasson, Paola, additional, Annoni, Giorgio, additional, Bruni, Adriana, additional, Confalonieri, Roberto, additional, Corsi, Maurizio, additional, Moretti, Daniela, additional, Teruzzi, Fabiola, additional, Umidi, Simona, additional, Mazzola, Paolo, additional, Perego, Sabrina, additional, Persico, Ilaria, additional, Olivieri, Giulia, additional, Bonfanti, Alessandra, additional, Hajnalka, Szabò, additional, Galeazzi, Marianna, additional, Massariello, Francesca, additional, Anzuini, Alessandra, additional, Caffarra, Paolo, additional, Barocco, Federica, additional, Spallazzi, Marco, additional, Paolo, Ceda Gian, additional, Simonetta, Morganti, additional, Andrea, Artoni, additional, Chioatto, Paolo, additional, Bortolamei, Sandra, additional, Soattin, Lucia, additional, Ruotolo, Giovanni, additional, Beneamino, Borelli, additional, Giuseppe, Barilaro, additional, Bertazzoli, Marco, additional, Rota, Elisabetta, additional, Adobati, Annamaria, additional, Scarpa, Alberto, additional, Granziera, Serena, additional, Zuccher, Paola, additional, Fabbro, Angela Dal, additional, Zara, Daniela, additional, Lo Nigro, Ambra, additional, Franchetti, Lorena, additional, Toniolo, Marika, additional, Marcuzzo, Cinzia, additional, Rollone, Marco, additional, Guerriero, Fabio, additional, Sgarlata, Carmelo, additional, Massè, Alessandro, additional, Zatti, Giovanni, additional, Piatti, Massimiliano, additional, Graci, Jole, additional, Benati, Giuseppe, additional, Boschi, Federica, additional, Biondi, Mario, additional, Fiumi, Nicoletta, additional, Erika, Tamburini, additional, Locatelli, Sergio Mario, additional, Mauri, Sabrina, additional, Beretta, Mauro, additional, Margheritis, Laura, additional, Desideri, Giovanbattista, additional, Liberatore, Ester, additional, Carucci, Anna Cecilia, additional, Bonino, Paolo, additional, Caput, Margherita, additional, Antonietti, Maria Paola, additional, Polistena, Giuseppe, additional, De la Pierre, Franz, additional, Mari, Marcello, additional, Massignani, Paola, additional, Tombesi, Fabio, additional, Selvaggio, Fabio, additional, Verbo, Brunella, additional, Bodoni, Paolo, additional, Marchionni, Niccolò, additional, Sabatini, Tony, additional, Mussio, Eleonora, additional, Magni, Eugenio, additional, Bianchetti, Angelo, additional, Crucitti, Andrea, additional, Titoldini, Giulia, additional, Cossu, Beatrice, additional, Fascendini, Sara, additional, Licini, Cristina, additional, Tomasoni, Angela, additional, Calderazzo, Massimo, additional, Daniela, Tropiano, additional, Valentina, Laganà, additional, Melotti, Rita Maria, additional, Lilli, Albina, additional, Buda, Simona, additional, Adversi, Marco, additional, Noro, Gabriele, additional, Turco, Renato, additional, Ubezio, M Chiara, additional, Mantovani, Anna Roberta, additional, Viola, Maria Cristina, additional, Serrati, Carlo, additional, Pretta, Stefano, additional, Infante, Maria, additional, Gentile, Simona, additional, Morandi, Alessandro, additional, D'Ambrosio, Viviana, additional, Mazzanti, Paolo, additional, Brambilla, Cristina, additional, Sportelli, Silvia, additional, Platto, Caterina, additional, Faraci, Bianca, additional, Quattrocchi, Daniela, additional, Pernigotti, Luigi Maria, additional, Pisu, Cristina, additional, Sicuro, Francesca, additional, Zagnoni, Piergiuseppe, additional, Ghiglia, Stefania, additional, Mosca, Massimiliano, additional, Corazzin, Ileana, additional, Deola, Mariangela, additional, Biagini, Carlo Adriano, additional, Bencini, Francesca, additional, Cantini, Claudia, additional, Tonon, Elisabetta, additional, Pierinelli, Silvia, additional, Onofrj, Marco, additional, Thomas, Astrid, additional, Filomena, Borbone, additional, Bonanni, Laura, additional, Gabriella, Cacchiò, additional, Comi, Giancarlo, additional, Magnani, Giuseppe, additional, Santangelo, Roberto, additional, Mazzeo, Salvatore, additional, Giuseppe, Magnani, additional, Francesca, Caso, additional, Giordano, Cecchetti, additional, Roberto, Sant'Angelo, additional, Barbieri, Cristina, additional, Giroldi, Liviana, additional, Bandini, Fabio, additional, Masina, Marco, additional, Malservisi, Simona, additional, Cicognani, Annalena, additional, Ricca, Laura, additional, Piccininni, Maristella, additional, Tassinari, Tiziana, additional, Brogi, Davide, additional, Sugo, Annalisa, additional, Alessandra, Filippi, additional, Sonia, Manfredi, additional, Valerio, Vanni, additional, Andrea, Usai Carlo, additional, Enrico, Colombo, additional, Vera, Renna Francesca, additional, Assunta, Sauchella, additional, Gianmaria, Zavarise, additional, Mauro, Prete, additional, Pietro, Bisagni, additional, Roberto, Masini, additional, Salvatore, Carrabetta, additional, Barone, Antonella, additional, Razzano, Monica, additional, Giuseppe, Imperoli, additional, Angela, Bini, additional, Francesco, Serra, additional, Valeria, D'Agostino, additional, Federico, Gianolla, additional, Lucia, Pietrangeli, additional, Antonella, Velardi, additional, Elisabetta, Di Cello, additional, Cristina, Rosati, additional, Nadia, Casali, additional, Maria, Sessa, additional, Luciano, Abruzzi, additional, Chiara, Costanzi, additional, Bini, Paolo, additional, Pignata, Michele, additional, Enrico, Buonagurio, additional, Maria, Vollery, additional, Giovanni, Carrieri, additional, Giorgio, Cioni, additional, Andrea, Toschi, additional, Marco, Metra, additional, Piera, Ranieri, additional, Alberto, Zucchelli, additional, Ceccon, Anna, additional, Magrin, Laura, additional, Marin, Sara, additional, Barbara, Sofia, additional, Marco, Masina, additional, Laura, Ghedini, additional, Matteo, Moroni, additional, Marco, Paragona, additional, Caterina, Pallotti Maria, additional, Carla, Rota, additional, Federica, Gottardi, additional, Clara, Tomasoni, additional, Melania, Cappuccio, additional, Giampaolo, Bonini, additional, Stefano, Guerini, additional, Valeria, Guerini, additional, Lucia, Merla, additional, Giovambattista, Desideri, additional, Ester, Liberatore, additional, Cecilia, Carucci Anna, additional, Maurizio, Tovaglieri, additional, Vera, Renna Frandesca, additional, Nadia, Bongiorni, additional, Grillo, Antonio, additional, Arenare, Francesca, additional, Tonino, Mineo, additional, David, Kanah, additional, Giorgio, Vianello Piero, additional, Ubaldo, Balducci, additional, Vincenzo, Sidoti, additional, Stefano, Montanari, additional, Marino, Formilan, additional, Busonera Flavio, Murelli Teodolindo, additional, Paolo, Albanese, additional, Monica, Maselli, additional, Francesco, Bolzetta, additional, Roberto, Fabris, additional, Paolo, Bonino, additional, DuranteMangoni, Emanuele, additional, Testoni, Michela, additional, Fabio, Di Stefano, additional, Loredana, Seccia, additional, Valeria, Sonzini, additional, Fabiano, Maria, additional, Annabella, Di Giorgio, additional, Salvatore, De Cosmo, additional, Greco, Antonio, additional, Grazia, D'Onofrio, additional, Daniele, Sancarlo, additional, Gianluca, Resta, additional, Renzo, Girardello, additional, Sergio, Minervini, additional, Morena, Boni, additional, Vitali, Mariagrazia, additional, Marina, Pizzoni, additional, Paolo, De Colle, additional, Cristina, Scarpa, additional, Alessandra, Frattola, additional, Orlandini, Francesco, additional, La Regina, Micaela, additional, Desirée, Addesi, additional, Mirella, Filippo, additional, Mario, Bo, additional, Paola, Porrino, additional, Padulo, Filomena, additional, Cristina, Margheriti, additional, Dario, Rolano, additional, Giancarla, Moscatelli, additional, Guido, Radaelli, additional, Elena, Montini, additional, Prete, Cosimo, additional, Marileda, Novello, additional, Igor, Bramuzzo, additional, Nicole, Bertin, additional, Elena, Rinaldo, additional, Paolillo, Ciro, additional, Riccardi, Angela, additional, Claudia, Benedetti, additional, Barbara, Rizzi, additional, Francesca, Montagna, additional, Silvia, Vitali, additional, Chiara, Cutaia, additional, Oliver, Baca, additional, Mauro, Colombo, additional, Eleonora, Marelli, additional, Giuseppe, Procino, additional, Rosaria, Tararà, additional, Maria, Cottino, additional, Davide, Dell'Acqua, additional, Stefania, Cislaghi, additional, Marco, Cairati, additional, Massimo, Porta, additional, Luca, Scaglione, additional, Martina, De Feo, additional, Paola, Vertolli, additional, Lia, Salvati, additional, Sandro, Cinotti, additional, Valentina, De Santis, additional, Erminia, Biferi, additional, Paola, Cheli, additional, Romina, Rebizzo, additional, Minisola, Salvatore, additional, Luciano, Colangelo, additional, Pasquale, Abete, additional, Ilaria, Liguori, additional, Francesca, Curcio, additional, Guglielmo, Spassini, additional, Marco, Engheben, additional, Sara, Rotunno, additional, Paola, Arosio, additional, Claudio, Angelini, additional, Francesco, Reggiani, additional, Alessandro, Cappelli, additional, Simona, Marcheselli, additional, Lara, Fratticci, additional, Paola, Ranzani, additional, Simonetta, Cesarini, additional, Antonella, Cerini, additional, Generoso, Uomo, additional, Fernando, Gallucci, additional, Giuliano, Ceschia, additional, Emanuela, Serra, additional, Mariolina, Sola, additional, Alessandro, Delitala, additional, Chiara, Pes, additional, Giulia, Lobianco, additional, Alessandro, Giani, additional, Famularo, Simone, additional, Sandini, Marta, additional, Pinotti, Enrico, additional, Gianotti, Luca, additional, Antonella, Battuello, additional, Giulia, Pintore, additional, Sante, Giardini, additional, Rossi, Andrea, additional, Rubele, Sofia, additional, Sant, Selena, additional, Marco, Vignati, additional, Danila, Clerici, additional, Fabio, Rosa, additional, Bandirali, Maria Pia, additional, Nicoletta, Cattaneo, additional, Laura, Boffi, additional, Paolo, Tosoni, additional, Luciano, Terranova, additional, Leonello, Avalli, additional, Margherita, Scanziani, additional, Stefania, De Notaris, additional, Pierluigi, Del Santo, additional, Laura, Rossi, additional, Fabiana, Tezza, additional, Giovanna, Cervati, additional, Antonino, Andreolli, additional, Felice, Catalano, additional, Giuseppe, Burattin, additional, Danilo, Fogli, additional, Giovanna, Di Bella, additional, Francesco, Landi, additional, Salini, Sara, additional, Angela, Brunetti Maria, additional, Giorgetta, Cappa, additional, Giovanni, Galvagno, additional, Paola, Cena, additional, Gerardo, Bruno, additional, Silvio, Raspo, additional, Letizia, Semeraro, additional, Sabrina, Pedrotti, additional, Davide, Barra, additional, Rosaria, Rizzo Maria, additional, Maria, Dalise Anna, additional, Raffaele, Prestano, additional, Palmieri, Vincenzo Ostilio, additional, Palasciano, Giuseppe, additional, Belfiore, Anna, additional, Portincasa, Piero, additional, Carlo, Sabbà, additional, Vincenzo, Solfrizzi, additional, Alessia, D'introno, additional, Valiani, Vincenzo, additional, Carolina, Bologna, additional, Tiziana, Ciarambino, additional, Paola, Turelli, additional, Ugo, Pazzaglia, additional, Federica, Rodella, additional, Giacomo, Piana, additional, Castellano, Maurizio, additional, Anna, Garelli, additional, Elisa, Casella, additional, Federica, Campana, additional, Antonietta, Coschignano Maria, additional, Luigi, Marinangeli, additional, Fabio, Lorico, additional, Salvatore, Bazzano, additional, Giuseppe, Menculini, additional, Gelosa, Giorgio, additional, Viviana, Ambrogio Teresa, additional, Piras, Valentina, additional, Andrea, Ciricugno, additional, Alessandra, Bollari, additional, Coen, Daniele, additional, Magliola, Renata, additional, Milanesio, Deborah, additional, Muzzulini, Carlo Lorenzo, additional, Paolo, Fogliacco, additional, Marinella, Turla, additional, Sofia, Cotelli Maria, additional, Marta, Bianchi, additional, Siano, Pietro, additional, Capo, Giuseppe, additional, Napoletano, Rosa, additional, Cecilia, Politi, additional, Mancini, Concetta, additional, Del Buono, Corrado, additional, De Bartolomeo, Giuseppe, additional, Addolorata, Martinelli, additional, Carmen, Cefalogli, additional, Roberto, Cozzi, additional, Giovanni, Virtuani Angelo, additional, Moschettini, Gianfilippo, additional, Franco, Mastroianni, additional, Daniela, Roglia, additional, D'Amico, Gabriella, additional, Mirella, Palella, additional, Endrizzi, Cristina, additional, Trotta, Lucia, additional, Ciarambino, Tiziana, additional, Orazio, Zanetti, additional, Emanuela, Terazzi, additional, Marta, Sacchetti, additional, Thomas, Fleetwood, additional, Giacomo, Tondo, additional, Ignazio, Di Fazio, additional, Andrea, Bruni, additional, Giuseppe, Orsitto, additional, Emanuela, Fabbro, additional, Serena, Amici, additional, Elena, D'Imporzano, additional, Anna, Casanova, additional, Serena, Bertolio, additional, Erika, Nervo, additional, Roberto, Silvestri, additional, Elena, Semproni, additional, Manuela, Pintus, additional, Francesca, Aloe, additional, and Angelo, Tagliaccica, additional

Published
2020
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28. Contrasting Divergent and Convergent Thinking by Electroencephalography and Eye Tracking

Author

Alessandro Laspia, Francesca Montagna, and Peter Törlind

Subjects
medicine.diagnostic_test, media_common.quotation_subject, Convergent thinking, Cognition, Adaptation (eye), Electroencephalography, Creativity, Task (project management), medicine, Eye tracking, Psychology, Divergent thinking, media_common, Cognitive psychology
Abstract

The present study explores the adoption of electroencephalography and eye tracking to assess physiological differences between divergent and convergent thinking. In neuroscientific literature alpha power synchronization in the right parietal lobe has been associated to top-down inhibition of task-irrelevant cognitive processes occurring during divergent thinking, but findings in oculometric studies seem to suggest a bottom-up process operated by active visual-gating. In the present study, 14 male engineering students performed an adaptation of the Alternative Uses task under two experimental conditions. During the task brainwaves and ocular activity were collected using electroencephalography and eye tracking, but results did not reach statistical significance. Improvements in the experimental setting and analysis method to overcome similar problems are presented. Future studies should further delve into the influences on results of experimental settings and of analysis methods to increase comparability among physiological studies.

Published
2019
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29. Unpacking the innovation toolbox for design research and practice

Author

Marco Cantamessa and Francesca Montagna

Subjects
Unpacking, Research design, Knowledge management, Visual Arts and Performing Arts, business.industry, Computer science, 05 social sciences, 0211 other engineering and technologies, General Engineering, Innovation management, 02 engineering and technology, Design domain, Toolbox, Domain (software engineering), Modeling and Simulation, 0502 economics and business, 050211 marketing, business, Representation (mathematics), Engineering design process, 021106 design practice & management
Abstract

The terms design and innovation are intuitively related, but the relationship between these two concepts is more complex and subtle than it appears at first sight. Few authors have made rigorous attempts to explore this relationship in depth, and the contributions present in the literature generally suffer the specialist backgrounds on which they are grounded. Consequently, this paper provides a high-level synthesis of the innovation management domain and defines an original framework that allows the positioning of the concepts from Innovation Management that are most relevant for scholars and practitioners operating in the Design domain. Specifically, this framework provides a concise representation of the typologies of innovation activities along the technology lifecycle, and associates them to their business implications and to technical and organizational implications on the design process. This framework allows scholars and practitioners from both fields to identify the typical design challenges that are inherent to each type of innovation activity, and to evaluate the suitability of specific support methods and tools.

Published
2019
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30. Managing Sociotechnical Complexity in Engineering Design Projects

Author

Francesca Montagna, Mohammad Hassannezhad, Marco Cantamessa, P. John Clarkson, Hassannezhad, Mohammad [0000-0002-3277-3222], and Apollo - University of Cambridge Repository

Subjects
0209 industrial biotechnology, Sociotechnical system, Process management, Process modeling, business.industry, Computer science, Mechanical Engineering, 0211 other engineering and technologies, Automotive industry, 02 engineering and technology, 4010 Engineering Practice and Education, Computer Graphics and Computer-Aided Design, Computer Science Applications, 020901 industrial engineering & automation, Resource (project management), Mechanics of Materials, New product development, Resource allocation, Project management, business, Engineering design process, 021106 design practice & management, 40 Engineering
Abstract

Design project management is witnessing an increasing need for practitioners to rely on tools that reflect the integrated nature of the social and technical characteristics of design processes, as opposed to considering the two as separate concepts. For practitioners, this integration has the potential value of predicting the future behavior of design processes by allowing them to understand what task to do next, whom to assign a task given the availability of resource, and the levels of knowledge and expertise required. In response to these challenges, this paper contributes to the development of a new process modeling method, called actor-based signposting (ABS), that looks at the early stages of the product development processes from the perspective of integrated sociotechnical systems. The objective is to support managers and decision-makers on both typical planning issues, such as scheduling and resource allocation, and less conventional issues relating to the organizational planning of a design project, such as identification of criticalities, matching required skills and expertise, and factors of influence. Ultimately, the aim is to support organizations to be more adaptive in responding to change and uncertainty. Two case studies in the automotive and aerospace industries with different properties and modeling objectives were selected to demonstrate the utility of the proposed method. Experimental analysis of these cases led to a range of insights regarding the future of modeling for academia as well as the decision-making capabilities for managers and practitioners.

Published
2019

31. AN ONTOLOGICAL FRAMEWORK TO LINK MARKETING AND DESIGN

Author

Francesca Montagna and Alessandro Casagrande-Seretti

Subjects
Requirements management, communication, integrated product development, requirements management, requirements management, communication, business.industry, Computer science, Language barrier, Cultural diversity, New product development, Ontology, Product (category theory), Marketing, Set (psychology), business, Consumer behaviour, integrated product development
Abstract

Communication issues between people with different backgrounds within the product development teams are commonplace. The causes are many, including cultural differences and language barriers. Nevertheless, cooperation between Marketing and Design was proved to be strongly correlated with product success. In this paper, we study an ontological way to overcome this problem. The framework is built on the FBS ontology and refers to Consumer Behaviour theories. It was tested on a set of 77 products.

Published
2018
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32. When Lifecycle Cost Analysis Enables Strategic Design Considerations

Author

Francesca Montagna and Stefania Altavilla

Subjects
Strategic design, Risk analysis (engineering), Computer science, Cluster (physics), Cost analysis, Product (category theory), Variety (cybernetics)
Abstract

The literature on cost-estimation is full of examples that methodologically explain the construction of models. In this paper, we showed how such methods when correctly implemented represent a source of structured information for in-depth design decisions. We investigated the impact of variety proliferation overall lifecycle costs, assessing differences in product architectures using a cluster analysis. The evidence collected serves as validation of a cost model approach and provides a decision-making support for choosing between platform solutions against a knowledge of costs consequences.

Published
2018

33. A Multilayer Taxonomy of Cost Estimation Techniques, Looking at the Whole Product Lifecycle

Author

Marco Cantamessa, Francesca Montagna, and Stefania Altavilla

Subjects
0209 industrial biotechnology, 021103 operations research, Cost estimate, Computer science, business.industry, Management science, Mechanical Engineering, media_common.quotation_subject, Multitude, 0211 other engineering and technologies, 02 engineering and technology, Ambiguity, Viewpoints, Industrial and Manufacturing Engineering, Computer Science Applications, 020901 industrial engineering & automation, Product lifecycle, Risk analysis (engineering), Conceptual design, Control and Systems Engineering, New product development, business, Implementation, media_common
Abstract

Product cost estimation (PCE) still draws the attention of researchers and practitioners, even though it has been extensively discussed in the literature for more than 20 years. This is due to its central impact on the company's performance. Nowadays, the adoption of cost estimation methods seems to be limited, despite the multitude of examples and applications available. A possible reason is the multitude of approaches and techniques proposed in the literature, which, instead of representing a guide for enabling possible implementations, actually create confusion and ambiguity on their appropriateness for a particular application. Hence, this paper aims to provide a systematic review of the recent literature in the field of PCE, and intensively investigates the aspects that can enable a more conscious decision on the type of technique to be adopted. This results in the identification of five different perspectives, which can be taken simultaneously into account. By combining the different viewpoints, a new multilayer framework is derived, with a specific focus on the whole product life cycle. The proposed framework can be used as a decision-making tool by both researchers and practitioners. In fact, the former group can benefit from the new structure, as a way to identify new areas of possible research opportunities. The latter group is provided an operative guide for the application in industrial contexts.

Published
2017
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34. Spike-Specific Memory B Cell Response in Hematopoietic Cell Transplantation Recipients following Multiple mRNA-1273 Vaccinations: A Longitudinal Observational Study

Author

Elena Pettini, Annalisa Ciabattini, Fabio Fiorino, Jacopo Polvere, Gabiria Pastore, Monica Tozzi, Francesca Montagnani, Giuseppe Marotta, Alessandro Bucalossi, and Donata Medaglini

Subjects
mRNA-based vaccine, allogeneic hematopoietic cell transplantation recipients, vaccination, SARS-CoV-2, spike-specific memory B cells, Medicine
Abstract

Preventing SARS-CoV-2 infection is of utmost importance in allogeneic hematopoietic cell transplantation patients (allo-HCT), given their heightened susceptibility to adverse outcomes associated with SARS-CoV-2 infection. However, limited data are available regarding the immune response to COVID-19 vaccines in these subjects, particularly concerning the generation and persistence of spike-specific memory response. Here, we analyzed the spike-specific memory B cells in a cohort of allo-HCT recipients vaccinated with multiple doses of the mRNA-1273 vaccine and monitored the spike-specific antibody response from baseline up to one month after the fourth dose. After the primary vaccine series, the frequency of spike-specific B cells, detected within the pool of Ig-switched CD19+ cells, significantly increased. The booster dose further induced a significant expansion, reaching up to 0.28% of spike-specific B cells. The kinetics of this expansion were slower in the allo-HCT recipients compared to healthy controls. Spike-specific IgG and ACE2/RBD binding inhibition activity were observed in 80% of the allo-HCT recipients after the first two doses, with a significant increase after the third and fourth booster doses, including in the subjects who did not respond to the primary vaccine series. Additionally, 87% of the allo-HCT recipients exhibited positive cross-inhibition activity against the BA.1 variant. Our findings provide evidence that allo-HCT recipients need repeated doses of the mRNA-1273 vaccine to induceSARS-CoV-2 specific immune response similar to that observed in healthy individuals. This is particularly crucial for vulnerable individuals who may exhibit a limited response to the primary series of SARS-CoV-2 vaccination.

Published
2024
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35. Who has the development process in his hands?

Author

Marco Cantamessa and Francesca Montagna

Subjects
Economics and Econometrics, Process management, business.industry, Business process, Process (engineering), media_common.quotation_subject, Strategy and Management, Power (social and political), Identification (information), Negotiation, Consistency (negotiation), Management of Technology and Innovation, New product development, Relevance (information retrieval), Business, Business and International Management, media_common
Abstract

In literature, many contributions discuss the importance of 'Process Owners' in business processes. This issue is highly relevant to product development, this often being the most strategically important, but also the most highly dispersed and knowledge-intensive process found in companies. Despite the relevance attributed to this role, few authors discuss the problem of identifying to whom the responsibility of Process Ownership should be given. The paper provides an approach, inspired by multiple-issue actor analysis methodologies, which supports a rigorous identification of the Process Owner by evaluating candidate actors' consistency with process goals, their influence on the process, and their negotiating power. Then the paper presents the application of this approach to the product development process in an Italian aerospace company.

Published
2017

36. How to practise Open Innovation today: what, where, how and why

Author

Enrico Vezzetti, Francesca Montagna, and Federica Marcolin

Subjects
Cultural Studies, Knowledge management, Visual Arts and Performing Arts, Process (engineering), business.industry, Strategy and Management, Communication, 05 social sciences, Innovation process, Intellectual property, 050905 science studies, Frequent use, Creative economy, Management, Management of Technology and Innovation, 0502 economics and business, Technology transfer, Openness to experience, 0509 other social sciences, business, 050203 business & management, Open innovation
Abstract

Open Innovation (OI), a paradigm coined by Chesbrough in 2003, is not only ‘openness towards innovation’, it also represents a firm-view-point-based innovation strategy, which suggests the involvement of external actors in the innovation process. The present paper is part of an on-going discussion on open issues related to OI and the advantages, strengths, challenges and limits of its implementation, dealing with the frequently debated topic of the future of this paradigm. What has emerged from this study is that a clear one-way outline of the OI implementation process does not exist, either in the literature or in practical cases, but common catalyst points, such as a general ‘open’ attitude, the existence of a technology transfer approach, an Intellectual Property protection strategy, and the frequent use of search routines, are identifiable. However, the future of this paradigm is not clear, as the concept may fade away because the process could be fully integrated in the innovation process.

Published
2017

37. Exploring the Cognitive Dynamics of Product Appreciation

Author

Niccolò Becattini, Francesca Montagna, and Gaetano Cascini

Subjects
Knowledge management, business.industry, Situated, Perspective (graphical), New product development, Key (cryptography), Plan (drawing), Product (category theory), Product planning, business, Psychology, Strengths and weaknesses, Cognitive psychology
Abstract

Understanding users’ choices is the key to both plan and design a product having higher chances of market success. Designers and marketing professional adopt different approaches for such investigation and the lack of a shared perspective between them can represent, by itself, one of the causes of no success in the market arena. This paper presents an approach that aims at focusing on how customers/users interpret product features and link them to their own needs. The theoretical framework behind the proposed approach is based on the latest updates of the situated FBS framework. An illustrative application in the field of sport shoes clarifies strengths and weaknesses of the proposal.

Published
2017
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38. On the Factors Affecting Design Education Within a Multi-Disciplinary Class

Author

Francesca Montagna, Gaetano Cascini, Federico Rotini, and Serena Graziosi

Subjects
Class (computer programming), Multi disciplinary, Computer science, General Engineering, team working, 02 engineering and technology, 021001 nanoscience & nanotechnology, design practice, Team working, Design education, Engineering (all), 0202 electrical engineering, electronic engineering, information engineering, Mathematics education, educational background, multi-disciplinary design, 020201 artificial intelligence & image processing, 0210 nano-technology
Published
2017

39. B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV

Author

Jacopo Polvere, Massimiliano Fabbiani, Gabiria Pastore, Ilaria Rancan, Barbara Rossetti, Miriam Durante, Sara Zirpoli, Enrico Morelli, Elena Pettini, Simone Lucchesi, Fabio Fiorino, Mario Tumbarello, Annalisa Ciabattini, Francesca Montagnani, and Donata Medaglini

Subjects
Medicine
Abstract

Polvere et al. investigate B cell responses after SARS-CoV-2 vaccination in people living with HIV undergoing anti-retroviral therapy. Spike-specific humoral and B cell responses persist for at least six months although a reduced ACE2/RBD binding inhibition capacity and different memory B phenotypes are observed compared to healthy controls.

Published
2023
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40. B cell analyses after SARS-CoV-2 mRNA third vaccination reveals a hybrid immunity like antibody response

Author

Emanuele Andreano, Ida Paciello, Giulio Pierleoni, Giulia Piccini, Valentina Abbiento, Giada Antonelli, Piero Pileri, Noemi Manganaro, Elisa Pantano, Giuseppe Maccari, Silvia Marchese, Lorena Donnici, Linda Benincasa, Ginevra Giglioli, Margherita Leonardi, Concetta De Santi, Massimiliano Fabbiani, Ilaria Rancan, Mario Tumbarello, Francesca Montagnani, Claudia Sala, Duccio Medini, Raffaele De Francesco, Emanuele Montomoli, and Rino Rappuoli

Subjects
Science
Abstract

SARS-CoV-2 vaccines and infection induce antibody responses but the evolution of subsequent variants has resulted in the development of escape mutants. Here the authors characterise, at single cell level, the antibody response in donors after a third dose of SARS-CoV-2 mRNA vaccination and show difference in breadth, neutralisation and molecular signature according to the vaccination regimen used.

Published
2023
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41. Sensitivity Analysis of Dynamic Cell Formation Problem through Meta-heuristic

Author

Mohammad Hassannezhad, Francesca Montagna, Fahad Mehmood, Marco Cantamessa, Hassannezhad, Mohammad [0000-0002-3277-3222], and Apollo - University of Cambridge Repository

Subjects
Mathematical optimization, cell formation problem, Cellular manufacturing, Cell formation, meta-heuristic, Local optimum, sensitivity analysis, modified self-adaptive differential evolution algorithm, Differential evolution, General Earth and Planetary Sciences, Meta heuristic, Sensitivity (control systems), Representation (mathematics), Algorithm, General Environmental Science, Integer (computer science), Mathematics
Abstract

In spite of many researches in literature investigating dynamic of cell formation (CF) problem, further research needs to be elaborated to assay hidden aspects of cellular manufacturing system (CMS), due to inherent complexity and uncertainty on optimizing this problem. In this paper, sensitivity analysis of modified self-adaptive differential evolution (MSDE) algorithm is proposed for basic parameters of CF problem, considering to the graphical representation supported by statistical analysis. Hence, a dynamic integer model of CF problem is first presented as the NP-hard problem. Then, the two basic test CF problems are introduced thereby the performance of MSDE algorithm assessed by diverse problems sizes through 140 runs from aspects of the average runtime of algorithm and the best local optimum objective function. Finally, statistical analysis is implemented on behavior of objective function values in order to validate our computational results graphically as well as statistically, giving some insights related to importance of CF parameters on designing CMS.

Published
2014
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42. Making Lean Smart by Using System-of-Systems' Approach

Author

Francesca Montagna and Asif Mahmood

Subjects
System of systems, Engineering, Scope (project management), Computer Networks and Communications, business.industry, Lean manufacturing, Field (computer science), Manufacturing engineering, Computer Science Applications, Lean project management, Control and Systems Engineering, Order (exchange), Secondary sector of the economy, Systems engineering, Lean software development, Electrical and Electronic Engineering, business, Information Systems
Abstract

System of systems (SoS) is quite a new approach in the practical field that is on the verge of transcending the boundaries of the defense system and ready to be applied in the industrial sector. This paper attempts to answer the important question of whether a production system falls under the scope of SoS by using a general framework proposed by the system theory. This also unearths the need to radicalize lean manufacturing with state-of-the-art tools. In order to achieve this objective, we design and elaborate a new management framework for an SoS lean or smart lean system by applying the SoS approach to lean manufacturing.

Published
2013
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43. Management of Innovation and Product Development : Integrating Business and Technological Perspectives

Author

Marco Cantamessa, Francesca Montagna, Marco Cantamessa, and Francesca Montagna

Subjects
New products, New products--Management, Technological innovations--Management
Abstract

Presenting an integrated and holistic perspective on innovation management and product design and development, this monograph offers a unique and original understanding of how these two perspectives are interconnected. This book explores these themes in a scientifically rigorous manner, associating academic findings with examples from business. It provides readers with the conceptual and decision-making tools required to understand and manage the process of innovation at different levels, from the analysis of industry-wide phenomena to the formulation of a strategy and from the planning of operations to the management of technical choices. Chapters cover innovation as an economic and social phenomenon, the formulation of innovation strategy, the management of product development processes and projects and the technical design of products and services. Offering an invaluable resource to postgraduate students in economics, business and engineering, this book is also intended for managers and entrepreneurs.

Published
2016

44. Costimulatory Pathways in Kidney Transplantation: Pathogenetic Role, Clinical Significance and New Therapeutic Opportunities

Author

Carmelo Libetta, Gianluca Marchi, Teresa Rampino, Gianluca Fasoli, Giuseppe Sileno, Pasquale Esposito, Antonio Dal Canton, Francesca Montagna, Fabrizio Grosjean, and Marilena Gregorini

Subjects
Graft Rejection, CD40, biology, medicine.medical_treatment, T cell, Immunology, CD28, Adaptive Immunity, Acquired immune system, Kidney Transplantation, Belatacept, Transplantation, Cytokine, medicine.anatomical_structure, Costimulatory and Inhibitory T-Cell Receptors, Drug development, biology.protein, medicine, Humans, Immunology and Allergy, Kidney Diseases, Antibodies, Blocking, Signal Transduction, medicine.drug
Abstract

Costimulatory pathways play a key role in immunity, providing the second signal required for a full activation of adaptive immune response. Different costimulatory families (CD28, TNF-related, adhesion and TIM molecules), characterized by structural and functional analogies, have been described. Costimulatory molecules modulate T cell activation, B cell function, Ig production, cytokine release and many other processes, including atherosclerosis. Patients suffering from renal diseases present significant alterations of the costimulatory pathways, which might make them particularly liable to infections. These alterations are further pronounced in patients undergoing kidney transplantation. In these patients, different costimulatory patterns have been related to distinct clinical features. The importance that costimulation has gained during the last years has led to development of several pharmacological approaches to modulate this critical step in the immune activation. Different drugs, mainly monoclonal antibodies targeting various costimulatory molecules (i.e. anti-CD80, CTLA-4 fusion proteins, anti-CD154, anti-CD40, etc.) were designed and tested in both experimental and clinical studies. The results of these studies highlighted some criticisms, but also some promising findings and now costimulatory blockade is considered a suitable strategy, with belatacept (a CTLA-4 fusion protein) being approved as the first costimulatory blocker for use in renal transplantation. In this review, we summarize the current knowledge on costimulatory pathways in the setting of kidney transplantation. We describe the principal costimulatory molecule families, their role and clinical significance in patients undergoing renal transplantation and the new therapeutic approaches that have been developed to modulate the costimulatory pathways.

Published
2013
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45. Selective Bilirubin Removal as Treatment of Jaundice-Related Kidney Injury

Author

Giuseppe Sileno, Teresa Rampino, Gianluca Fasoli, Antonio Dal Canton, Pasquale Esposito, Gianluca Marchi, Maria Luisa Scaramuzzi, and Francesca Montagna

Subjects
chemistry.chemical_compound, medicine.medical_specialty, chemistry, Bilirubin, business.industry, Internal medicine, medicine, Kidney injury, General Medicine, Jaundice, medicine.symptom, business, Gastroenterology
Published
2013
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46. Usage of SoS methodologies in production system design

Author

Marco Cantamessa, Arianna Alfieri, Francesca Montagna, and Elisabetta Raguseo

Subjects
System of systems, Engineering, General Computer Science, business.industry, media_common.quotation_subject, General Engineering, Variety (cybernetics), Task (project management), Interdependence, Risk analysis (engineering), Systems engineering, Production (economics), Systems design, Strategic management, Manufacturing operations, business, media_common
Abstract

Production systems design is a multifaceted task, due to a variety of aspects such as the mutual interdependency between the sub-systems, the variety of configurations and alternative system control strategies, the multiple managerial and ''soft'' aspects that cast an influence on the behavior of the system. A reasonable number of modeling tools can be applied to production system design, but they tend to divide the problem into unconnected sub-problems whose individual solutions may result in a poor global one. This is despite the fact that production design encompasses all aspects of manufacturing operations, and needs a systemic approach, as clearly shown in practitioner-oriented literature. This paper proposes to apply the ''System of Systems'' approach to production system design in order to represent their main aspects and support the rational definition of the path leading from corporate strategy to system (re)design.

Published
2013
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47. Design for Innovation – a methodology to engineer the innovation diffusion into the development process

Author

Francesca Montagna, Marco Cantamessa, and Gaetano Cascini

Subjects
Engineering, Knowledge management, General Computer Science, Process (engineering), 0211 other engineering and technologies, 02 engineering and technology, Innovation diffusion, Multi-issue Actor Strategy Analysis Model, Multi-stakeholder, Native needs, Reported needs, Computer Science (all), Engineering (all), 0502 economics and business, Meaning (existential), Product (category theory), 021106 design practice & management, Product innovation, business.industry, 05 social sciences, General Engineering, New product development, business, Ethnocomputing, 050203 business & management, Reciprocal, Quality function deployment
Abstract

A multi-actorial perspective of needs allows interpreting innovation diffusion processes.A QFD-derived methodology for considering innovation diffusion within product development.A multi-stakeholder model representing stakeholders' needs and their reciprocal influences. In its hyper-inflated usage, innovation simply means "something new", and is applied to any technical novelty. In its true meaning, innovating means designing something that will not only work under a technical point of view, but will also make business sense. "Design for Innovation" means considering that design cannot simply focus on a narrow meaning of "product use", because this could severely limit the diffusion of innovative products. The paper proposes an original model for representing what we call "beyond-use situations" and the influences among the actors involved in the innovation diffusion process.Taking inspiration from social influence network models and from the Multi-issue Actor Strategy Analysis Model (MASAM), the paper presents an operational methodology to assess the influence of different actors on the decision to adopt a new product. In turn, such methodology should support design teams to conceive novel solutions more likely to become factual innovations. The paper also describes a computer-implementable technique, loosely derived from Quality Function Deployment, to practically apply the proposed methodology. An industrial case study from the medical-care sector illustrates its logic and operational steps.

Published
2016

49. Hemodialysis vascular access: everything you always wanted to know about it (but were afraid to ask)

Author

C. Migotto, Massimo Torreggiani, Vittoria Esposito, Francesca Montagna, Noemi Maggi, Giuseppe Sileno, Ciro Esposito, Alessandra Manini, Maria Lucia Scaramuzzi, Francesca Castoldi, and Nicoletta Serpieri

Subjects
Catheterization, Central Venous, medicine.medical_specialty, business.industry, medicine.medical_treatment, Age Factors, Psychological intervention, MEDLINE, Arteriovenous fistula, medicine.disease, Europe, Catheter, Arteriovenous Shunt, Surgical, Renal Dialysis, Nephrology, medicine, Humans, Kidney Failure, Chronic, Hemodialysis, Physician's Role, business, Intensive care medicine, Developed country, Dialysis, Central venous catheter
Abstract

Vascular accesses are essential for effective dialysis treatment. Arteriovenous fistulas, grafts and central venous catheters are the options available to the nephrologist, but they all have their pros and cons. All of the 3 types of vascular access share the same complications but at different rates, and their costs vary enormously, with on balance the arteriovenous fistula being the best choice. Nevertheless, recently the number of incident patients starting dialysis treatment with a venous catheter as vascular access has been steadily increasing. This is true even for more advanced countries such as the United States, where despite the efforts made to promote the use of fistulas, their prevalence is still low compared with Europe. Moreover, nowadays nephrologists are required to master technical skills that once were those of surgeons and to perform interventions to preserve the patency of the access. The aim of this paper is to review the prevalence, benefits and complications of the different vascular accesses in light of the most recent findings.

Published
2012
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50. An empirical analysis of the PLM implementation effects in the aerospace industry

Author

Francesca Montagna, Paolo Neirotti, and Marco Cantamessa

Subjects
Engineering, Process management, General Computer Science, business.industry, Product Lifecycle Management (PLM), General Engineering, Effective management, New Product Development (NPD), Manufacturing engineering, Open research, Product lifecycle, New product development, Product management, business, Aerospace
Abstract

The provision of an effective IT support to product development processes still remains an open research question, because of the complexity that is inherent to this area of corporate activity. According to the current state of the art, product lifecycle management (PLM) systems can be considered as important enablers for achieving true coordination and effective management of product development processes. However, few contributions in literature investigate the central issue of understanding how company implementation approaches can mutually interact and can determine the actual effects of PLM introduction. The paper presents a framework for representing PLM implementation effects at three different levels (individual, organizational, and strategic) jointly to an empirical investigation in a major Italian aerospace company.

Published
2012
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