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1. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Author

Ahlqvist, Emma, Storm, Petter, Käräjämäki, Annemari, Martinell, Mats, Dorkhan, Mozhgan, Carlsson, Annelie, Vikman, Petter, Prasad, Rashmi B, Aly, Dina Mansour, Almgren, Peter, Wessman, Ylva, Shaat, Nael, Spégel, Peter, Mulder, Hindrik, Lindholm, Eero, Melander, Olle, Hansson, Ola, Malmqvist, Ulf, Lernmark, Åke, Lahti, Kaj, Forsén, Tom, Tuomi, Tiinamaija, Rosengren, Anders H, and Groop, Leif

Published
2018
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2. Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes

Author

Khunti, Kamlesh, Alsifri, Saud, Aronson, Ronnie, Cigrovski Berković, Maja, Enters-Weijnen, Catherine, Forsén, Tom, Galstyan, Gagik, Geelhoed-Duijvestijn, Petronella, Goldfracht, Margalit, Gydesen, Helge, Kapur, Rahul, Lalic, Nebojsa, Ludvik, Bernhard, Moberg, Erik, Pedersen-Bjergaard, Ulrik, and Ramachandran, Ambady

Published
2017
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3. Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

Author

Tuomi, Tiinamaija, Nagorny, Cecilia L.F., Singh, Pratibha, Bennet, Hedvig, Yu, Qian, Alenkvist, Ida, Isomaa, Bo, Östman, Bjarne, Söderström, Johan, Pesonen, Anu-Katriina, Martikainen, Silja, Räikkönen, Katri, Forsén, Tom, Hakaste, Liisa, Almgren, Peter, Storm, Petter, Asplund, Olof, Shcherbina, Liliya, Fex, Malin, Fadista, João, Tengholm, Anders, Wierup, Nils, Groop, Leif, and Mulder, Hindrik

Published
2016
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15. Birth Weight and Risk of Type 2 Diabetes: A Systematic Review

Author

Whincup, Peter H., Kaye, Samantha J., Owen, Christopher G., Huxley, Rachel, Cook, Derek G., Anazawa, Sonoko, Barrett-Connor, Elizabeth, Bhargava, Santosh K., Birgisdottir, Bryndís E., Carlsson, Sofia, de Rooij, Susanne R., Dyck, Roland F., Eriksson, Johan G., Falkner, Bonita, Fall, Caroline, Forsén, Tom, Grill, Valdemar, Gudnason, Vilmundur, Hulman, Sonia, Hyppönen, Elina, Jeffreys, Mona, Lawlor, Debbie A., Leon, David A., Minami, Junichi, Mishra, Gita, Osmond, Clive, Power, Chris, Rich-Edwards, Janet W., Roseboom, Tessa J., Sachdev, Harshpal Singh, Syddall, Holly, Thorsdottir, Inga, Vanhala, Mauno, Wadsworth, Michael, and Yarbrough, Donald E.

Published
2008

19. Birth Weight and Systolic Blood Pressure in Adolescence and Adulthood: Meta-Regression Analysis of Sex- and Age-specific Results from 20 Nordic Studies

Author

Gamborg, Michael, Byberg, Liisa, Rasmussen, Finn, Andersen, Per Kragh, Baker, Jennifer L., Bengtsson, Calle, Canoy, Dexter, Drøyvold, Wenche, Eriksson, Johan G., Forsén, Tom, Gunnarsdottir, Ingibjörg, Järvelin, Marjo-Riitta, Koupil, Ilona, Lapidus, Leif, Nilsen, Tom I., Olsen, Sjurdur F., Schack-Nielsen, Lene, Thorsdottir, Inga, Tuomainen, Tomi-Pekka, and Sørensen, Thorkild I. A.

Published
2007

35. Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

Author

Mahajan, Anubha, Sim, Xueling, Ng, Hui Jin, Manning, Alisa, Rivas, Manuel A., Highland, Heather M., Locke, Adam E., Grarup, Niels, Im, Hae Kyung, Cingolani, Pablo, Flannick, Jason, Fontanillas, Pierre, Fuchsberger, Christian, Gaulton, Kyle J., Teslovich, Tanya M., Rayner, N. William, Robertson, Neil R., Beer, Nicola L., Rundle, Jana K., Bork-Jensen, Jette, Ladenvall, Claes, Blancher, Christine, Buck, David, Buck, Gemma, Burtt, Noël P., Gabriel, Stacey, Gjesing, Anette P., Groves, Christopher J., Hollensted, Mette, Huyghe, Jeroen R., Jackson, Anne U., Jun, Goo, Justesen, Johanne Marie, Mangino, Massimo, Murphy, Jacquelyn, Neville, Matt, Onofrio, Robert, Small, Kerrin S., Stringham, Heather M., Syvänen, Ann Christine, Trakalo, Joseph, Abecasis, Goncalo, Bell, Graeme I., Blangero, John, Cox, Nancy J., Duggirala, Ravindranath, Hanis, Craig L., Seielstad, Mark, Wilson, James G., Christensen, Cramer, Brandslund, Ivan, Rauramaa, Rainer, Surdulescu, Gabriela L., Doney, Alex S F, Lannfelt, Lars, Linneberg, Allan, Isomaa, Bo, Tuomi, Tiinamaija, Jørgensen, Marit E., Jørgensen, Torben, Kuusisto, Johanna, Uusitupa, Matti, Salomaa, Veikko, Spector, Timothy D., Morris, Andrew D., Palmer, Colin N A, Collins, Francis S., Mohlke, Karen L., Bergman, Richard N., Ingelsson, Erik, Lind, Lars, Tuomilehto, Jaakko, Hansen, Torben, Watanabe, Richard M., Prokopenko, Inga, Dupuis, Josee, Karpe, Fredrik, Groop, Leif, Laakso, Markku, Pedersen, Oluf, Florez, Jose C., Morris, Andrew P., Altshuler, David, Meigs, James B., Boehnke, Michael, McCarthy, Mark I., Lindgren, Cecilia M., Gloyn, Anna L., Abboud, Hanna E., Afzal, Uzma, Aguilar, David, Arya, Rector, Atzmon, Gil, Aung, Tin, Banks, Eric, Barroso, Inês, Barzilai, Nir, Below, Jennifer E., Bharadwaj, Dwaipayan, Blackwell, Thomas W., Bonnycastle, Lori L., Bowden, Don, Carey, Jason, Carneiro, Mauricio O., Chambers, John C., Chan, Edmund, Chan, Juliana, Chandak, Giriraj R., Chen, Peng, Chen, Yuhui, Chen, Han, Cheng, Ching Yu, Chia, Kee Seng, Cho, Yoon Shin, Correa, Adolfo, Curran, Joanne E., Daly, Mark J., Day-Williams, Aaron G., DeFronzo, Ralph A., DePristo, Mark, Donnelly, Peter J., Ebrahim, Shah B., Elliott, Paul, Esko, Tõnu, Fadista, João, Farjoun, Yossi, Farmer, Andrew J., Farook, Vidya S., Fennell, Timothy, Ferreira, Teresa, Fingerlin, Tasha, Forsén, Tom, Fowler, Sharon P., Franks, Paul W., Frayling, Timothy M., Freedman, Barry I., Froguel, Philippe, Gamazon, Eric R., Gieger, Christian, Glaser, Benjamin, Go, Min Jin, Goldstein, Jacqueline I., Grallert, Harald, Grant, George, Green, Todd, Griswold, Michael, Hale, Daniel Esten, Han, Bok Ghee, Hartl, Christopher, Hattersley, Andrew T., Hicks, Pamela J., Hodgkiss, Dylan, Horikoshi, Momoko, Hrabé de Angelis, Martin, Hu, Cheng, Hu, Frank B., Huh, Iksoo, Kamran Ikram, Mohammad, Illig, Thomas, Jablonski, Kathleen A., Jenkinson, Christopher P., Jia, Weiping, Kang, Hyun Min, Khor, Chiea Chuen, Kim, Yongkang, Kim, Young Jin, Kim, Bong Jo, Kinnunen, Leena, Kooner, Jaspal Singh, Kravic, Jasmina, Kriebel, Jennifer, Kumar, Ashish, Kumar, Satish, Kuulasmaa, Teemu, Kwon, Min Seok, Langenberg, Claudia, Lauritzen, Torsten, Lee, Selyeong, Lee, Jaehoon, Lee, Juyoung, Lee, Jong Young, Lehman, Donna M., Lehne, Benjamin, Levy, Jonathan C., Li, Jiang, Liang, Liming, Lim, Wei Yen, Lin, Keng Han, Liu, Jianjun, Loh, Marie, Ma, Ronald C W, Ma, Clement, Mägi, Reedik, Maguire, Jared, Maxwell, Taylor J., McVean, Gilean, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Metspalu, Andres, Mihailov, Evelin, Milani, Lili, Moutsianas, Loukas, Müller-Nurasyid, Martina, K. Musani, Solomon, Nagai, Yoshihiko, Narisu, Narisu, Neale, Benjamin M., Ng, Maggie C Y, Nilsson, Peter, O'Rahilly, Stephen P., Orho-Melander, Marju, Owen, Katharine R., Palmer, Nicholette D., Park, Taesung, Pasko, Dorota, Pearson, Richard D., Perry, John R B, Peters, Annette, Pollin, Toni I., Poplin, Ryan, Prabhakaran, Dorairaj, Puppala, Sobha, Purcell, Shaun, Qi, Lu, Qi, Qibin, Roden, Michael, Rolandsson, Olov, Rosengren, Anders H., Sandhu, Manjinder, Schwarzmayr, Thomas, Scott, Laura J., Scott, Robert A., Scott, James, Scott, William R., Sehmi, Jobanpreet, Shakir, Khalid, Sladek, Rob, Smith, Joshua D., Stancáková, Alena, Strauch, Konstantin, Strom, Tim M., Swift, Amy, Tai, E. Shyong, Tajes, Juan Fernandez, Tan, Sian Tsung, Tandon, Nikhil, Taylor, Herman A., Teo, Yik Ying, Thameem, Farook, Thorand, Barbara, van de Bunt, Martijn, Varga, Tibor V., Walker, Mark, Wareham, Nicholas J., Welch, Ryan P., Wieland, Thomas, Wilson, Gregory, Wong, Tien Yin, Wood, Andrew R., Yoon, Joon, Zeggini, Eleftheria, and Zhang, Weihua

Abstract

Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry. We found exome-wide significant (P

Published
2015
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37. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

Author

Flannick, Jason, Thorleifsson, Gudmar, Beer, Nicola L, Jacobs, Suzanne B R, Grarup, Niels, Burtt, Noël P, Mahajan, Anubha, Fuchsberger, Christian, Atzmon, Gil, Benediktsson, Rafn, Blangero, John, Bowden, Don W, Brandslund, Ivan, Brosnan, Julia, Burslem, Frank, Chambers, John, Cho, Yoon Shin, Christensen, Cramer, Douglas, Desirée A, Duggirala, Ravindranath, Dymek, Zachary, Farjoun, Yossi, Fennell, Timothy, Fontanillas, Pierre, Forsén, Tom, Gabriel, Stacey, Glaser, Benjamin, Gudbjartsson, Daniel F, Hanis, Craig, Hansen, Torben, Hreidarsson, Astradur B, Hveem, Kristian, Ingelsson, Erik, Isomaa, Bo, Johansson, Stefan, Jørgensen, Torben, Jørgensen, Marit Eika, Kathiresan, Sekar, Kong, Augustine, Kooner, Jaspal, Kravic, Jasmina, Laakso, Markku, Lee, Jong-Young, Lind, Lars, Lindgren, Cecilia M, Linneberg, Allan, Masson, Gisli, Meitinger, Thomas, Ribel-Madsen, Rasmus, Pedersen, Oluf, Flannick, Jason, Thorleifsson, Gudmar, Beer, Nicola L, Jacobs, Suzanne B R, Grarup, Niels, Burtt, Noël P, Mahajan, Anubha, Fuchsberger, Christian, Atzmon, Gil, Benediktsson, Rafn, Blangero, John, Bowden, Don W, Brandslund, Ivan, Brosnan, Julia, Burslem, Frank, Chambers, John, Cho, Yoon Shin, Christensen, Cramer, Douglas, Desirée A, Duggirala, Ravindranath, Dymek, Zachary, Farjoun, Yossi, Fennell, Timothy, Fontanillas, Pierre, Forsén, Tom, Gabriel, Stacey, Glaser, Benjamin, Gudbjartsson, Daniel F, Hanis, Craig, Hansen, Torben, Hreidarsson, Astradur B, Hveem, Kristian, Ingelsson, Erik, Isomaa, Bo, Johansson, Stefan, Jørgensen, Torben, Jørgensen, Marit Eika, Kathiresan, Sekar, Kong, Augustine, Kooner, Jaspal, Kravic, Jasmina, Laakso, Markku, Lee, Jong-Young, Lind, Lars, Lindgren, Cecilia M, Linneberg, Allan, Masson, Gisli, Meitinger, Thomas, Ribel-Madsen, Rasmus, and Pedersen, Oluf

Abstract

Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been described for type 2 diabetes (T2D). Through sequencing or genotyping of ~150,000 individuals across 5 ancestry groups, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.Trp325Arg) associated with T2D risk and glucose and proinsulin levels. Collectively, carriers of protein-truncating variants had 65% reduced T2D risk (P = 1.7 × 10(-6)), and non-diabetic Icelandic carriers of a frameshift variant (p.Lys34Serfs*50) demonstrated reduced glucose levels (-0.17 s.d., P = 4.6 × 10(-4)). The two most common protein-truncating variants (p.Arg138* and p.Lys34Serfs*50) individually associate with T2D protection and encode unstable ZnT8 proteins. Previous functional study of SLC30A8 suggested that reduced zinc transport increases T2D risk, and phenotypic heterogeneity was observed in mouse Slc30a8 knockouts. In contrast, loss-of-function mutations in humans provide strong evidence that SLC30A8 haploinsufficiency protects against T2D, suggesting ZnT8 inhibition as a therapeutic strategy in T2D prevention.

Published
2014

38. Prenatal and Childhood Growth, and Hospitalization for Alcohol Use Disorders in Adulthood: The Helsinki Birth Cohort Study

Author

Lahti, Jari, primary, Lahti, Marius, additional, Pesonen, Anu-Katriina, additional, Heinonen, Kati, additional, Kajantie, Eero, additional, Forsén, Tom, additional, Wahlbeck, Kristian, additional, Osmond, Clive, additional, Barker, David J. P., additional, Eriksson, Johan G., additional, and Räikkönen, Katri, additional

Published
2014
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39. Role of socioeconomic indicators on development of obesity from a life course perspective.

Author

Salonen, Minna K., Kajantie, Eero, Osmond, Clive, Forsén, Tom, Hilkka Ylihärsilä, Paile-Hyvärinen, Maria, Barker, David J. P., Eriksson, Johan G., Forsén, Tom, Ylihärsilä, Hilkka, and Paile-Hyvärinen, Maria

Subjects
OBESITY, BODY mass index, SOCIAL classes, BODY weight, SOCIAL status, EDUCATIONAL attainment, OBESITY in women, RESEARCH, CROSS-sectional method, RESEARCH methodology, EVALUATION research, MEDICAL cooperation, OCCUPATIONS, INCOME, SOCIOECONOMIC factors, COMPARATIVE studies, DISEASE prevalence, RESEARCH funding, MARITAL status, DEMOGRAPHY, ODDS ratio, POVERTY, LONGITUDINAL method
Abstract

Aims: Development of obesity is modified by several factors, including socioeconomic ones. We studied the importance of socioeconomic indicators on the development of obesity from a life course perspective.Methods: 2003 people born 1934-1944 in Helsinki, Finland, participated in clinical examinations in 2001-2004. Obesity was defined as body mass index (BMI) >30 kg/m(2).Results: Prevalence of obesity was 22.3% in men and 27.2% in women. Lower educational attainment and lower adult social class were associated with higher BMI in both men (P = .03 and P < .01) and women (P < .001 and P = .01). Childhood social class was inversely associated with BMI only in men (P < .001); lower household income was associated with higher BMI in women only (P < .001). Those men belonging to the lowest childhood social class had higher risk of being obese than those of the highest childhood social class (OR 1.8 (95% CI: 1.0-3.1)). Household income was the strongest predictor of obesity among women.Conclusion: Overweight and obesity are inversely associated with socioeconomic status. Men seem to be more susceptible to adverse childhood socioeconomic circumstances than women, while adult socioeconomic indicators were more strongly associated with obesity in women. [ABSTRACT FROM AUTHOR]

Published
2009
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40. Childhood growth and hypertension in later life.

Author

Eriksson, Johan G., Forsén, Tom J., Kajantie, Eero, Osmond, Clive, Barker, David J. P., and Forsén, Tom J

Abstract

Few studies have examined the effects of both prenatal and postnatal growth on hypertension. We report on hypertension in 2003 people aged 62 years who were randomly selected from the Helsinki birth cohort and examined in a clinic. Their heights and weights had been recorded serially up to age 11 years. A total of 644 had already been diagnosed with hypertension. Compared with normotensive people, they were obese and insulin resistant. At birth they were thin and short, and they gained weight slowly up to age 2 years; thereafter they grew rapidly so that at age 11 years their body size was around the average. The odds ratio associated with each kilogram of birthweight was 0.42 (95% CI: 0.32 to 0.56); with each 10 kg of current weight it was 1.85 (95% CI: 1.66 to 2.05). The blood pressures of another 802 people were classified as hypertensive under current definitions. They were overweight and had an atherogenic lipid profile. At birth they were short, and after birth they grew slowly so that at age 11 years they were short and thin. The odds ratio associated with each kilogram of weight at age 2 years was 0.75 (95% CI: 0.68 to 0.84); with each 10 kg of current weight it was 1.42 (95% CI: 1.28 to 1.57). We conclude that 2 different paths of childhood growth precede the development of hypertension. We suggest that they lead to hypertension through different biological mechanisms and may respond differently to medication. [ABSTRACT FROM AUTHOR]

Published
2007
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41. Birth weight and systolic blood pressure in adolescence and adulthood:meta-regression analysis of sex- and age-specific results from 20 Nordic studies

Author

Gamborg, Michael, Byberg, Liisa, Rasmussen, Finn, Andersen, Per Kragh, Baker, Jennifer L., Bengtsson, Calle, Canoy, Dexter, Drøyvold, Wenche, Eriksson, Johan G., Forsén, Tom, Gunnarsdottir, Ingibjörg, Järvelin, Marjo-Riitta, Koupil, Ilona, Lapidus, Leif, Nilsen, Tom I., Olsen, Sjurdur F., Schack-Nielsen, Lene, Thorsdottir, Inga, Tuomainen, Tomi-Pekka, Sørensen, Thorkild I.A., Gamborg, Michael, Byberg, Liisa, Rasmussen, Finn, Andersen, Per Kragh, Baker, Jennifer L., Bengtsson, Calle, Canoy, Dexter, Drøyvold, Wenche, Eriksson, Johan G., Forsén, Tom, Gunnarsdottir, Ingibjörg, Järvelin, Marjo-Riitta, Koupil, Ilona, Lapidus, Leif, Nilsen, Tom I., Olsen, Sjurdur F., Schack-Nielsen, Lene, Thorsdottir, Inga, Tuomainen, Tomi-Pekka, and Sørensen, Thorkild I.A.

Published
2007

42. The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth.

Author

Eriksson, Johan G., Lindi, Virpi, Uusitupa, Matti, Forsén, Tom J., Laakso, Markku, Osmond, Clive, Barker, David J.P., and Forsén, Tom J

Subjects
GENETIC polymorphisms, PEROXISOMES, INSULIN
Abstract

Type 2 diabetes is known to be associated with a small body size at birth. Body size at birth is an indicator of the intrauterine environment. There is also a well-established association between the peroxisome proliferator-activated receptor (PPAR)-gamma2 gene and type 2 diabetes. We therefore assessed whether the effects of the Pro12Ala polymorphism of the PPAR-gamma2 gene on insulin sensitivity and insulin concentrations in adult life are modified by size at birth. We found that the effects of the Pro12Pro and Pro12Ala polymorphisms of the PPAR-gamma2 gene in elderly people depended on their body size at birth. The well-known association between small body size at birth and insulin resistance was seen only in individuals with the high-risk Pro12Pro allele. In those who had low birth weight, the Pro12Pro polymorphism of the PPAR-gamma2 gene was associated with increased insulin resistance (P < 0.002) and elevated insulin concentrations (P < 0.003). These interactions between the effects of the Pro12Ala polymorphisms of the PPAR-gamma2 gene on adult traits and the effects of birth weight link two previously unknown associations together within the context of type 2 diabetes. We suggest that these findings reflect gene-environment interaction. [ABSTRACT FROM AUTHOR]

Published
2002
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48. Cardiovascular health of Finnish war evacuees 60 years later

Author

Alastalo, Hanna, primary, Räikkönen, Katri, additional, Pesonen, Anu-Katriina, additional, Osmond, Clive, additional, Barker, David J. P., additional, Kajantie, Eero, additional, Heinonen, Kati, additional, Forsén, Tom J., additional, and Eriksson, Johan G., additional

Published
2009
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49. Infant Growth and Hostility in Adult Life

Author

Rkkönen, Katri, primary, Pesonen, Anu-Katriina, additional, Heinonen, Kati, additional, Lahti, Jari, additional, Kajantie, Eero, additional, Forsén, Tom, additional, Osmond, Clive, additional, Barker, David J.P., additional, and Eriksson, Johan G., additional

Published
2008
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