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Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
- Source :
- Mahajan, A, Sim, X, Ng, H J, Manning, A, Rivas, M A, Highland, H M, Locke, A E, Grarup, N, Im, H K, Cingolani, P, Flannick, J, Fontanillas, P, Fuchsberger, C, Gaulton, K J, Teslovich, T M, Rayner, N W, Robertson, N R, Beer, N L, Rundle, J K, Bork-Jensen, J, Ladenvall, C, Blancher, C, Buck, D, Buck, G, Burtt, N P, Gabriel, S, Gjesing, A P, Groves, C J, Hollensted, M, Huyghe, J R, Jackson, A U, Jun, G, Justesen, J M, Mangino, M, Murphy, J, Neville, M, Onofrio, R, Small, K S, Stringham, H M, Syvänen, A C, Trakalo, J, Abecasis, G, Bell, G I, Blangero, J, Cox, N J, Duggirala, R, Hanis, C L, Seielstad, M, Wilson, J G, Christensen, C, Brandslund, I, Rauramaa, R, Surdulescu, G L, Doney, A S F, Lannfelt, L, Linneberg, A, Isomaa, B, Tuomi, T, Jørgensen, M E, Jørgensen, T, Kuusisto, J, Uusitupa, M, Salomaa, V, Spector, T D, Morris, A D, Palmer, C N A, Collins, F S, Mohlke, K L, Bergman, R N, Ingelsson, E, Lind, L, Tuomilehto, J, Hansen, T, Watanabe, R M, Prokopenko, I, Dupuis, J, Karpe, F, Groop, L, Laakso, M, Pedersen, O, Florez, J C, Morris, A P, Altshuler, D, Meigs, J B, Boehnke, M, McCarthy, M I, Lindgren, C M, Gloyn, A L, Abboud, H E, Afzal, U, Aguilar, D, Arya, R, Atzmon, G, Aung, T, Banks, E, Barroso, I, Barzilai, N, Below, J E, Bharadwaj, D, Blackwell, T W, Bonnycastle, L L, Bowden, D, Carey, J, Carneiro, M O, Chambers, J C, Chan, E, Chan, J, Chandak, G R, Chen, P, Chen, Y, Chen, H, Cheng, C Y, Chia, K S, Cho, Y S, Correa, A, Curran, J E, Daly, M J, Day-Williams, A G, DeFronzo, R A, DePristo, M, Donnelly, P J, Ebrahim, S B, Elliott, P, Esko, T, Fadista, J, Farjoun, Y, Farmer, A J, Farook, V S, Fennell, T, Ferreira, T, Fingerlin, T, Forsén, T, Fowler, S P, Franks, P W, Frayling, T M, Freedman, B I, Froguel, P, Gamazon, E R, Gieger, C, Glaser, B, Go, M J, Goldstein, J I, Grallert, H, Grant, G, Green, T, Griswold, M, Hale, D E, Han, B G, Hartl, C, Hattersley, A T, Hicks, P J, Hodgkiss, D, Horikoshi, M, Hrabé de Angelis, M, Hu, C, Hu, F B, Huh, I, Kamran Ikram, M, Illig, T, Jablonski, K A, Jenkinson, C P, Jia, W, Kang, H M, Khor, C C, Kim, Y, Kim, Y J, Kim, B J, Kinnunen, L, Kooner, J S, Kravic, J, Kriebel, J, Kumar, A, Kumar, S, Kuulasmaa, T, Kwon, M S, Langenberg, C, Lauritzen, T, Lee, S, Lee, J, Lee, J, Lee, J Y, Lehman, D M, Lehne, B, Levy, J C, Li, J, Liang, L, Lim, W Y, Lin, K H, Liu, J, Loh, M, Ma, R C W, Ma, C, Mägi, R, Maguire, J, Maxwell, T J, McVean, G, Meisinger, C, Meitinger, T, Melander, O, Metspalu, A, Mihailov, E, Milani, L, Moutsianas, L, Müller-Nurasyid, M, K. Musani, S, Nagai, Y, Narisu, N, Neale, B M, Ng, M C Y, Nilsson, P, O'Rahilly, S P, Orho-Melander, M, Owen, K R, Palmer, N D, Park, T, Pasko, D, Pearson, R D, Perry, J R B, Peters, A, Pollin, T I, Poplin, R, Prabhakaran, D, Puppala, S, Purcell, S, Qi, L, Qi, Q, Roden, M, Rolandsson, O, Rosengren, A H, Sandhu, M, Schwarzmayr, T, Scott, L J, Scott, R A, Scott, J, Scott, W R, Sehmi, J, Shakir, K, Sladek, R, Smith, J D, Stancáková, A, Strauch, K, Strom, T M, Swift, A, Tai, E S, Tajes, J F, Tan, S T, Tandon, N, Taylor, H A, Teo, Y Y, Thameem, F, Thorand, B, van de Bunt, M, Varga, T V, Walker, M, Wareham, N J, Welch, R P, Wieland, T, Wilson, G, Wong, T Y, Wood, A R, Yoon, J, Zeggini, E & Zhang, W 2015, ' Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus ', PL o S Genetics, vol. 11, no. 1, e1004876 . https://doi.org/10.1371/journal.pgen.1004876
- Publication Year :
- 2015
-
Abstract
- Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry. We found exome-wide significant (P
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Mahajan, A, Sim, X, Ng, H J, Manning, A, Rivas, M A, Highland, H M, Locke, A E, Grarup, N, Im, H K, Cingolani, P, Flannick, J, Fontanillas, P, Fuchsberger, C, Gaulton, K J, Teslovich, T M, Rayner, N W, Robertson, N R, Beer, N L, Rundle, J K, Bork-Jensen, J, Ladenvall, C, Blancher, C, Buck, D, Buck, G, Burtt, N P, Gabriel, S, Gjesing, A P, Groves, C J, Hollensted, M, Huyghe, J R, Jackson, A U, Jun, G, Justesen, J M, Mangino, M, Murphy, J, Neville, M, Onofrio, R, Small, K S, Stringham, H M, Syvänen, A C, Trakalo, J, Abecasis, G, Bell, G I, Blangero, J, Cox, N J, Duggirala, R, Hanis, C L, Seielstad, M, Wilson, J G, Christensen, C, Brandslund, I, Rauramaa, R, Surdulescu, G L, Doney, A S F, Lannfelt, L, Linneberg, A, Isomaa, B, Tuomi, T, Jørgensen, M E, Jørgensen, T, Kuusisto, J, Uusitupa, M, Salomaa, V, Spector, T D, Morris, A D, Palmer, C N A, Collins, F S, Mohlke, K L, Bergman, R N, Ingelsson, E, Lind, L, Tuomilehto, J, Hansen, T, Watanabe, R M, Prokopenko, I, Dupuis, J, Karpe, F, Groop, L, Laakso, M, Pedersen, O, Florez, J C, Morris, A P, Altshuler, D, Meigs, J B, Boehnke, M, McCarthy, M I, Lindgren, C M, Gloyn, A L, Abboud, H E, Afzal, U, Aguilar, D, Arya, R, Atzmon, G, Aung, T, Banks, E, Barroso, I, Barzilai, N, Below, J E, Bharadwaj, D, Blackwell, T W, Bonnycastle, L L, Bowden, D, Carey, J, Carneiro, M O, Chambers, J C, Chan, E, Chan, J, Chandak, G R, Chen, P, Chen, Y, Chen, H, Cheng, C Y, Chia, K S, Cho, Y S, Correa, A, Curran, J E, Daly, M J, Day-Williams, A G, DeFronzo, R A, DePristo, M, Donnelly, P J, Ebrahim, S B, Elliott, P, Esko, T, Fadista, J, Farjoun, Y, Farmer, A J, Farook, V S, Fennell, T, Ferreira, T, Fingerlin, T, Forsén, T, Fowler, S P, Franks, P W, Frayling, T M, Freedman, B I, Froguel, P, Gamazon, E R, Gieger, C, Glaser, B, Go, M J, Goldstein, J I, Grallert, H, Grant, G, Green, T, Griswold, M, Hale, D E, Han, B G, Hartl, C, Hattersley, A T, Hicks, P J, Hodgkiss, D, Horikoshi, M, Hrabé de Angelis, M, Hu, C, Hu, F B, Huh, I, Kamran Ikram, M, Illig, T, Jablonski, K A, Jenkinson, C P, Jia, W, Kang, H M, Khor, C C, Kim, Y, Kim, Y J, Kim, B J, Kinnunen, L, Kooner, J S, Kravic, J, Kriebel, J, Kumar, A, Kumar, S, Kuulasmaa, T, Kwon, M S, Langenberg, C, Lauritzen, T, Lee, S, Lee, J, Lee, J, Lee, J Y, Lehman, D M, Lehne, B, Levy, J C, Li, J, Liang, L, Lim, W Y, Lin, K H, Liu, J, Loh, M, Ma, R C W, Ma, C, Mägi, R, Maguire, J, Maxwell, T J, McVean, G, Meisinger, C, Meitinger, T, Melander, O, Metspalu, A, Mihailov, E, Milani, L, Moutsianas, L, Müller-Nurasyid, M, K. Musani, S, Nagai, Y, Narisu, N, Neale, B M, Ng, M C Y, Nilsson, P, O'Rahilly, S P, Orho-Melander, M, Owen, K R, Palmer, N D, Park, T, Pasko, D, Pearson, R D, Perry, J R B, Peters, A, Pollin, T I, Poplin, R, Prabhakaran, D, Puppala, S, Purcell, S, Qi, L, Qi, Q, Roden, M, Rolandsson, O, Rosengren, A H, Sandhu, M, Schwarzmayr, T, Scott, L J, Scott, R A, Scott, J, Scott, W R, Sehmi, J, Shakir, K, Sladek, R, Smith, J D, Stancáková, A, Strauch, K, Strom, T M, Swift, A, Tai, E S, Tajes, J F, Tan, S T, Tandon, N, Taylor, H A, Teo, Y Y, Thameem, F, Thorand, B, van de Bunt, M, Varga, T V, Walker, M, Wareham, N J, Welch, R P, Wieland, T, Wilson, G, Wong, T Y, Wood, A R, Yoon, J, Zeggini, E & Zhang, W 2015, ' Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus ', PL o S Genetics, vol. 11, no. 1, e1004876 . https://doi.org/10.1371/journal.pgen.1004876
- Accession number :
- edsair.od......2761..12d57813c67e797fbb7130c6c4089f25
- Full Text :
- https://doi.org/10.1371/journal.pgen.1004876