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Present Pasts: The Memory of Slavery in Brazil is a sound testament to the Brazilian public history movemen.This problematization of the “present pasts of slavery” finds fertile ground in Brazilian public history because of the urgent need to record and analyze representations of this traumatic past, going beyond professional and academic contexts to the public sphere. Public history offers reinvigorating possibilities for mediation between, and intervention in, the past and its publics.The Present Pasts Research Network provides a thought-provoking example of public history’s ability to be sensitive to broad public debate and how the needs, interests, and representations of communities can be addressed through historical representation, interpretation, and active history-making.

Made available in DSpace on 2020-12-12T02:05:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-08-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Objective: To investigate GTN lethality among Brazilian women comparing cases of death by GTN with those who survived, thereby identifying factors associated with GTN lethality. Methods: We retrospectively reviewed medical records of women with GTN treated at ten Brazilian GTN Reference Centers, from January 1960 to December 2017. We evaluated factors associated with death from GTN and used Cox proportional hazards regression models to identify independent variables with significant influence on the risk of death. Results: From 2186 patients with GTN included in this study, 2092 (95.7%) survived and 89 (4%) died due to GTN. When analyzing the relative risk (RR), adjusted for WHO/FIGO score, patients with low risk disease had a significantly higher risk of death if they had choriocarcinoma (RR: 12.40), metastatic disease (RR: 12.57), chemoresistance (RR: 3.18) or initial treatment outside the Reference Center (RR: 12.22). In relation to patients with high-risk GTN, these factors were significantly associated with death due to GTN: the time between the end of antecedent pregnancy and the initiation of chemotherapy (RR: 4.10), metastatic disease (RR: 14.66), especially in brain (RR: 8.73) and liver (RR: 5.76); absence of chemotherapy or initial treatment with single agent chemotherapy (RR: 10.58 and RR: 1.81, respectively), chemoresistance (RR: 3.20) and the initial treatment outside the Reference Center (RR: 28.30). Conclusion: The risk of mortality from low and high-risk GTN can be reduced by referral of these patients to a Reference Center or, if not possible, to involve clinicians in a Reference Center with consultation regarding management. Rio de Janeiro Trophoblastic Disease Center Maternity School of Rio de Janeiro Federal University Antonio Pedro University Hospital of Fluminense Federal University Postgraduate Program in Medical Sciences Fluminense Federal University Postgraduate Program in Perinatal Health Faculty of Medicine Maternity School of Rio de Janeiro Federal University Goiania Trophoblastic Disease Center Clinics Hospital of Goias Federal University Botucatu Trophoblastic Disease Center Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics São Paulo State University-UNESP Porto Alegre Trophoblastic Disease Center Mario Totta Maternity Ward Irmandade da Santa Casa de Misericórdia Hospital Caxias do Sul Trophoblastic Disease Center General Hospital of Caxias do Sul School of Medicine Center for Biological and Health Sciences Caxias do Sul University Campinas Trophoblastic Disease Center University of Campinas Jundiai Trophoblastic Disease Center Jundiai Medical School Santos Trophoblastic Disease Center Guilherme Álvaro Hospital Rio Branco Trophoblastic Disease Center Clinics Hospital of Acre São Paulo Hospital Trophoblastic Disease Center Paulista School of Medicine São Paulo Federal University New England Trophoblastic Disease Center Division of Gynecologic Oncology Department of Obstetrics Gynecology and Reproductive Biology Brigham and Women's Hospital Harvard Medical School Botucatu Trophoblastic Disease Center Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics São Paulo State University-UNESP CAPES: 001

The effect of hCG administration on accessory corpus luteum (ACL) formation, CL area, and plasma progesterone (P4) concentration (ng/mL) seven days after breeding was studied in nulliparous Santa Inês sheep. Intravaginal 60 mg MAP sponges were inserted into ewes for six days and 300 IU eCG i.m. and 30 ?g d-cloprostenol latero-vulvar were administered 24 h before sponge removal. Ewes were naturally bred and, seven days after first mating (Day 0; D0), were treated with either 250 IU hCG (hCG group; n = 7) or 1 mL saline solution (control group; n = 7). Blood was collected to determine plasma P4 concentrations and sonograms were performed on Days 7, 10, 13, 16, 19, and 22. Number of CL on D7 was similar (P > 0.05) between hCG (1.3 ± 0.5) and control (1.3 ± 0.5) groups; however, on D13, it was greater (P < 0.05) in the hCG group (2.3 ± 0.5) than in the control group (1.3 ± 0.5). A greater (P < 0.05) luteal tissue area was detected in hCG-treated ewes (n = 4) on Days 16 to 22 than in the animals in the control group (n = 7). Plasma P4 concentration on D13 to D22 was higher (P < 0.05) in hCG-treated animals than in control ewes. Administration of hCG seven days after estrus onset efficiently induced accessory CL formation in ewes, increasing luteal tissue area and plasma P4 concentration. . Made available in DSpace on 2018-07-20T00:51:56Z (GMT). No. of bitstreams: 1 CNPC2018Effects.pdf: 275893 bytes, checksum: 20e76f7c09a690bd0c0eee5fd7f392e1 (MD5) Previous issue date: 2018-07-19

Made available in DSpace on 2022-04-28T19:51:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Resistance to glyphosate herbicide has initiated usage of combined application of herbicides as a weed control measure. Imazethapyr-based herbicides associated with glyphosate herbicide seem to be an alternative to suppress weed resistance. The aim of this study was to examine the adverse effects of Glyphosate Atanor 48® (ATN) and Imazethapyr Plus Nortox® (IMZT) formulations in both single forms and mixtures using HepG2 cells and zebrafish early-life stages models. Data demonstrated cytotoxicity due to exposure to ATN, IMZT for both models, as follows: (1) ATN (0.5 mg/L), IMZT (5 mg/L), and M3 (0.05 mg/L ATN + 5 mg/L IMZT) increased cytotoxicity by disturbing the mitochondrial activity of HepG2 cells 24 hr after exposure; (2) ATN and IMZT (5 mg/L), and M3 (0.05 mg/L ATN + 5 mg/L IMZT) also decreased the integrity of the membrane of HepG2 cells after 24 hr incubation; (3) only ATN and IMZT (5 mg/L) in their single forms diminished the mitochondrial potential of zebrafish; (4) ATN (single form) at 0.5 mg/L induced apoptosis in zebrafish larvae. In conclusion, these herbicides in their single forms appeared to produce greater cytotoxicity to HepG2 cells and zebrafish compared to the herbicide mixtures. Environmental Toxicology Research Laboratory Faculty of Pharmacy Federal University of Goiás Department of Biophysics and Biometry Institute of Biology Roberto Alcantara Gomes State University of Rio de Janeiro Laboratory of Teaching and Research in Toxicology in Vitro Faculty of Pharmacy Federal University of Goiás Department of Pharmacy and Pharmaceutical Administration Pharmacy College Fluminense Federal University Institute of Chemistry National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives UNESP Departament of Genetics Federal University of Paraná Institute of Chemistry National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives UNESP

Made available in DSpace on 2022-05-01T13:41:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 The aim of this study was to evaluate the effects of cleaning protocols on the presence of residues, open dentinal tubules, and bond strength of a self-etch adhesive plus a dual-cure resin cement to dentin in the fiber-post space. The methods for cleaning utilized were conventional irrigation (CI), rotary brush with continuous rotary movement (RB), and continuous ultrasonic irrigation (CUI). Sixty bovine incisors were used for fiber-post space preparation. Thirty roots were divided into three groups (n = 10) according to the cleaning protocols and submitted to scanning electron microscope to evaluate presence of residues and relative quantity of open dentinal tubules on dentin surface. Similar protocols were performed in the other thirty roots (n = 10) using a self-etching adhesive system (Scotchbond Universal) and a dual-cure resin cement (Relyx Unicem 2). After 6 months cervical, middle, and apical thirds sections of fiber-post space were submitted to push-out testing. To data ANOVA and Tukey's test were employed (α = 5%). RB and CUI showed the lowest presence of residues on dentin surface (p =.015) and the highest bond strength values (p

Made available in DSpace on 2022-04-28T19:44:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Purpose: The aim of this split-mouth randomized clinical trial was to evaluate the primary and secondary stability of implants with hydrophilic surfaces in comparison to implants with conventional surfaces in the posterior region of the maxilla. Materials and Methods: Twenty patients with a bilateral edentulous ridge in the posterior area of the maxilla randomly received implants with two types of surfaces: (1) implants with the surface modified by double acid-etching and sandblasting (DAS, n = 20); and (2) implants with the surface modified by double acid-etching and sandblasting, stored in 0.9% saline solution to confer highly hydrophilic properties (DAS-H, n = 20) on the surface. The implants presented the same macrostructure with a hybrid design. The resonance frequency analysis was performed in order to obtain the implant stability quotient (ISQ) using Osstell. The ISQ analyses were performed just after placement of the implant (primary stability) and at 28, 40, and 90 days after the surgical procedure (secondary stability). Results: There were no differences between the DAS and DAS-H surfaces in the primary stability or during the conversion of the primary to the secondary stability; however, there was a reduction in the stability of the implants at 28 days, which increased significantly at 40 and 90 days in both surfaces. Conclusion: It can be concluded that the surface wettability of implants with a hybrid macrostructure did not increase the primary and secondary implant stability in the posterior region of the maxilla Department of Periodontology and Implantodontology Federal University of Uberlandia (UFU) Department of Periodontology School of Dentistry University Center of Santa Fé do Sul (Unifunec) School of Dentistry University Center of the Educational Foundation of Barretos (UNIFEB) Department of Diagnosis and Surgery School of Dentistry State of São Paulo University (Unesp) Department of Specific Formation School of Dentistry Fluminense Federal University (UFF) Department of Diagnosis and Surgery School of Dentistry State of São Paulo University (Unesp)

In this article we study some statistical aspects of surface diffeomorphisms. We first show that for a $C^1$ generic diffeomorphism, a Dirac invariant measure whose \emph{statistical basin of attraction} is dense in some open set and has positive Lebesgue measure, must be supported in the orbit of a sink. We then construct an example of a $C^1$-diffeomorphism having a Dirac invariant measure, supported on a hyperbolic fixed point of saddle type, whose statistical basin of attraction is a nowhere dense set with positive Lebesgue measure. Our technique can be applied also to construct a $C^1$ diffeomorphism whose set of points with historic behaviour has positive measure and is nowhere dense., 63 pages, 26 figures. Final version, accepted in Journal of Dynamics and Differential Equations

Made available in DSpace on 2020-12-12T02:44:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 The volume of generated and stored data from social media has increased in the last decade. Therefore, analyzing and understanding this kind of data can offer relevant information in different contexts and can assist researchers and companies in the decision-making process. However, the data are scattered in a large volume, come from different sources, with different formats and are rapidly created. Such facts make the knowledge extraction difficult, turning it in a complex and high costly process. The scientific contribution of this paper is the development of a social media data integration model based on a data warehouse to reduce the computational costs related to data analysis, as well as support the application of techniques to discover useful knowledge. Differently from the literature, we focus on both social media Facebook and Twitter. Also, we contribute with the proposition of a model for the acquisition, transformation and loading data, which can enable the extraction of useful knowledge in a context where the human capability of understanding is exceeded. The results showed that the proposed data warehouse improves the quality of data mining algorithms compared to related works, while being able to reduce the execution time. Institute of Biosciences São Paulo State University (Unesp) Humanities and Exact Sciences (Ibilce), Campus São José do Rio Preto Fluminense Federal University (UFF) Institute of Biosciences São Paulo State University (Unesp) Humanities and Exact Sciences (Ibilce), Campus São José do Rio Preto

Made available in DSpace on 2022-04-28T19:45:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) This study aimed to evaluate the effects of conventional heat treatments (high-temperature–short-time and low-temperature–low-time) and high-intensity ultrasound (HIUS) on the physical stability and bacterial diversity of whole milk during refrigerated storage. HIUS processing used an energy density of 3 kJ/mL and an ultrasound intensity of 90 W/cm2. The most abundant bacterial genera found in raw milk were Acinetobacter and Pseudomonas. After processing and storage for 7 days, Acinetobacter, Kluyvera and Serratia were the dominant genera in almost all samples, and Pseudomonas was the most abundant in HIUS-processed milk. Only the HIUS process reduced the fat droplet size (

Made available in DSpace on 2022-04-29T08:39:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Objectives: To identify possible clinical factors associated with hyperthyroidism at presentation and to assess post-evacuation thyroid function in women with complete hydatidiform mole (CHM). Methods: This observational study included women with CHM attending a specialized Brazilian center in 2002–2018. Clinical and laboratory data (serum hCG, TSH, fT4) were collected at presentation. Factors associated with hyperthyroidism were assessed by logistic regression. Receiver-operating characteristic curves were built to determine the hCG cutoff for predicting hyperthyroidism at CHM presentation. Post-molar evacuation follow-up included clinical assessment and close thyroid function monitoring. Results: Of 137 CHM patients, 69 (50.3%) had hyperthyroidism of any type (43.5% subclinical, 56.5% overt) at presentation. Uterine fundal height > 16 cm or > gestational age (GA), and theca lutein cysts >6 cm were significantly associated with both subclinical and overt hyperthyroidism. The optimal hCG cutoff for predicting hyperthyroidism was 430,559 IU/L (sensitivity 85.5%, specificity 83.8%). Post-evacuation hyperthyroidism/transient hypothyroidism conversion was observed in 13% of the women with hyperthyroidism at presentation. Among the patients not showing conversion to hypothyroidism, median time for TSH normalization was 2 and 3 weeks for subclinical and overt hyperthyroidism, respectively. In the women with overt hyperthyroidism, fT4 was normalized at 2 weeks. Conclusions: Uterine fundal height > 16 cm, uterine fundal height > GA, theca lutein cysts >6 cm, and hCG >400,000 IU/L at presentation are associated with greater risk of hyperthyroidism and its complications. Close monitoring thyroid function during postmolar follow-up showed that, as thyroid hormones are normalized within 2–3 weeks post-evacuation, the use of beta-blockers or antithyroid drugs can be rapidly discontinued. Postgraduation Program in Tocoginecology Botucatu Medical School UNESP-São Paulo State University, SP Botucatu Trophoblastic Disease Center Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics UNESP-São Paulo State University, SP Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics UNESP-São Paulo State University, SP Endocrinology Clinic Department of Internal Medicine Botucatu Medical School UNESP-São Paulo State University, SP New England Trophoblastic Disease Center Division of Gynecologic Oncology Department of Obstetrics Gynecology and Reproductive Biology Brigham and Women's Hospital Harvard Medical School Department of Obstetrics and Gynecology Division of Gynecologic Oncology Brigham and Women's Hospital Rio de Janeiro Trophoblastic Disease Center Maternity School of Rio de Janeiro Federal University Antonio Pedro University Hospital Fluminense Federal University, RJ Postgraduation Program in Tocoginecology Botucatu Medical School UNESP-São Paulo State University, SP Botucatu Trophoblastic Disease Center Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics UNESP-São Paulo State University, SP Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics UNESP-São Paulo State University, SP Endocrinology Clinic Department of Internal Medicine Botucatu Medical School UNESP-São Paulo State University, SP

Made available in DSpace on 2020-12-12T01:39:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01 U.S. Army Medical Department Universidade do Estado do Rio de Janeiro Universidade Estadual Paulista Background: Considered the most common congenital testicular abnormality of companion animals and a predisposition factor to the development of testicular neoplasia, cryptorchidism is defined as the non-descent of one or both testes to their normal anatomical location. Data on the occurrence of cryptorchidism in Brazil are scarce. The purpose of this work was to verify the occurrence of cryptorchidism in dogs of different sizes and breeds. Materials and methods: Cryptorchidism identification was carried out by ultrasound scanning, from November, 1994 to March, 2007, at the Centre for Veterinarian Diagnosis and Support (Centro de Apoio e Diagnóstico Veterinário - CAD), in Rio de Janeiro. 4924 male dogs of different breeds were examined, revealing 403 (8.2%) cryptorchidism. Results: In this study, occurrence took place more often on the right testicle (59.5%), more frequently displaying inguinal localisation (59.5%) and unilateral occurrence (70%). Regarding bilateral presentation, the symmetrical form was the most common (86.8%). Cryptorchidism was more common in the inguinal region of dog of small sized breeds and in the abdominal region in dogs of medium- and large-sized breeds. Conclusions: Ultrasound scan proved a valuable diagnosis tool for cryptorchid testes, giving precise localisation and parenchymal changes thus leading to a safe clinical treatment. Autonomous Veterinarian Centre for Veterinarian Diagnosis and Support Centro de Apoio e Diagnóstico Veterinário - CAD Veterinarian Radiology and Animal Reproduction Department School of Veterinary Medicine and Animal Science UNESP Federal University of Acre Federal University of Pampa Morphology Department Fluminense Federal University Human and Animal Anatomy Department Rural Federal University of Rio de Janeiro Veterinarian Radiology and Animal Reproduction Department School of Veterinary Medicine and Animal Science UNESP

A large amount of dust from the Sahara reaches the Amazon Basin, as observed with satellite imagery. This dust is thought to carry micronutrients that could help fertilize the rainforest. However, considering different atmospheric transport conditions, different aridity levels in South America and Africa and active volcanism, it is not clear if the same pathways for dust have occurred throughout the Holocene. Here we present analyses of Sr-Nd isotopic ratios of a lacustrine sediment core from remote Lake Pata in the Amazon region that encompasses the past 7,500 years before present, and compare these ratios to dust signatures from a variety of sources. We find that dust reaching the western Amazon region during the study period had diverse origins, including the Andean region and northern and southern Africa. We suggest that the Sahara Desert was not the dominant source of dust throughout the vast Amazon basin over the past 7,500 years. Mineral dust deposited over the western Amazon region through the Holocene is not limited to a Saharan source and instead has diverse origins, according to geochemical fingerprinting of dust from lacustrine deposits.

International audience; Coastal wetlands are highly sensitive to changes occurring at the coastline. It is critically important to determine region-specific projections for these areas due to their specificities and vulnerabilities to climate change. This work aimed to value the impacts of recent climate changes at West Africa Sahara coastland, southern Morocco, at Khnifiss Lagoon. We have applied a combined approach using remote sensing techniques and environmental reconstructions based on high-resolution analysis of sediment cores, covering the current warm period. Remote sensing highlighted changes to the lagoon inlet, accompanied by a greater meandering character of the tidal channels. As a response, the sediment cores have recorded a predominant vegetation substitution due to changes in the tidal limit, and an increase in organic carbon accumulation was observed. For the current climatology, during positive phases of the North Atlantic Oscillation, winds reaching the coast strengthen in an east-to-west direction. In the Khnifiss Lagoon, whose inlet is dominated by the ebb tide, the intensity and direction of the winds on the coast at surface level modifies its connection to the ocean by increasing sediment transport toward the interior of the lagoon. Locally biological responses to wind intensification, and possibly sea-level rise, exemplify the lagoon sensitivity to large-scale processes. Coastal vegetated wetlands are considered to be highly dynamic environments. However, we expect a loss of the upper tidal vegetation due to boundary conditions limiting the accommodation space in this arid environment in a possible future scenario of continuously inland tidal line displacement.

International audience; BACKGROUND AND OBJECTIVES: Recent studies have shed light on the potential role of curcumin in mitigating inflammation in patients with chronic kidney disease (CKD). This study aimed to evaluate the effects of curcumin supplementation on plasma levels of markers of inflammation and oxidative stress in patients with CKD undergoing hemodialysis (HD). METHODS: These are secondary exploratory analyses from a previous double-blind, randomized controlled pilot study registered under ClinicalTrials.gov Identifier no. NCT00123456. It included 28 hemodialysis patients from a previous study divided into two groups: curcumin group (receiving juice with 2.5 g of turmeric 3×/week for 12 weeks) and a control group. The TNF-α, IL-6 and Ox-LDL plasma levels were measured by sandwich enzyme immunoassays ELISA; lipid peroxidation was measured by the reaction between malondialdehyde (MDA) and thiobarbituric acid. RESULTS: After 12 weeks of supplementation with curcumin, the TNF-α plasma levels were significantly reduced [from 15.0 (8.23-73.3) to 6.17 (1.11-55.0) pg/mL, p = 0.01]. CONCLUSION: 12 weeks of treatment with curcumin in HD patients resulted in a reduction in the biomarker of inflammation (TNF-α), confirming our previous hypothesis that curcumin has an anti-inflammatory effect.

International audience; This paper proposes a UHF flexible passive tag antenna for Radio Frequency Identification (RFID) which operates at 902-928 MHz frequency band. As main contribution, we design an electrically small and slim tag antenna by using a flexible commercial substrate. The small antenna has dimensions of 13 mm × 28 mm × 0.35 mm. The geometry of the tag antenna was optimized, using a Genetic Algorithm, to maximize its read range. The antenna performance was evaluated on flat and curve surfaces, by means of simulations of input impedance, reflection coefficient, gain and read range. Measurements of reflection coefficient were also developed. Results prove that the tag antenna can be wrapped on cylindrical surfaces with read ranges above one meter, suitable for applications related to industrial asset management, access control and identification of small objects such as hardware tools, tin cans, spray bottles and tin PET cylindrical containers.

Mucositis is an adverse effect of cancer chemotherapies using 5-Fluorouracil (5-FU). It is characterized by mucosal inflammation, pain, diarrhea, and weight loss. Some studies reported promising healing effects of probiotic strains, when associated with prebiotics, as adjuvant treatment of mucositis. We developed a lyophilized symbiotic product, containing skimmed milk, supplemented with whey protein isolate (WPI) and with fructooligosaccharides (FOS), and fermented by Lactobacillus casei BL23, Lactiplantibacillus plantarum B7, and Lacticaseibacillus rhamnosus B1. In a mice 5-FU mucositis model, this symbiotic lyophilized formulation was able to reduce weight loss and intestinal permeability. This last was determined in vivo by quantifying blood radioactivity after oral administration of 99mTc-DTPA. Finally, histological damages caused by 5-FU-induced mucositis were monitored. Consumption of the symbiotic formulation caused a reduced score of inflammation in the duodenum, ileum, and colon. In addition, it decreased levels of pro-inflammatory cytokines IL-1β, IL-6, IL-17, and TNF-α in the mice ileum. The symbiotic product developed in this work thus represents a promising adjuvant treatment of mucositis.

International audience

Made available in DSpace on 2019-10-06T17:10:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-15 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) A glassy carbon electrode (GCE) modified with reduced graphene oxide (RGO) and silver oxide nanoparticles (AgNPs-RGO/GCE) was prepared for electrocatalytic oxidation of amino acids. The modified electrode surface was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy and Raman spectroscopy. The results showed that the developed AgNPs had a medium diameter of 10 ± 2 nm besides being well dispersed on the RGO surface. The electrochemical behavior of the AgNPs-RGO/GCE in the oxidation of glycine, alanine, leucine, aspartic and glutamic acids was carried out by cyclic voltammetry and amperometric techniques. Voltammetric studies indicated a rise in the anodic peak of the silver (III) oxide species in the presence of amino acids. Essentially, this shows that amino acids were oxidized in the redox mediator was electrodeposited on the electrode surface via an electrocatalytic process. Based on Laviron's equation, the values of α and ks for the redox species were found to be 0.51 and 0.61 s−1, respectively. The catalytic rate constants of 1.4 × 108 (alanine) to 5.4 × 108 cm3 mol−1 s−1 (glycine), the transfer coefficients 0.37 (leucine) to 0.45 (glutamic acid), and the diffusion coefficients of 1.1 × 10−6 (alanine) to 7.7 × 10−6 cm2 s−1 (glycine) for the amino acids are reported. The excellent electrocatalytic activity, high sensitivity and good stability observed in our investigation renders the AgNPs-RGO/GCE promising for application as a suitable sensor for amino acids detection. São Paulo State University (UNESP) Institute of Chemistry São Paulo State University (UNESP) oenergy Research Institute School of Metallurgical and Industrial Engineering Fluminense Federal University (UFF) São Paulo State University (UNESP) Institute of Chemistry São Paulo State University (UNESP) oenergy Research Institute CNPq: 160604/2015-0 FAPESP: 2014/23846-5

Made available in DSpace on 2019-10-06T16:48:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-02 Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) This study evaluated the effect of the surface roughness parameters on the flexural strength of Yttria-partially stabilized zirconia, Y-TZP ceramics: ZrO2 (3 mol%) or ZrO2 (5 mol%), as function of different surface finishing protocols: polishing or alumina (Al2O3) blasting. Zirconia discs were manufactured by CAD/CAM prototyping and sintered at different temperatures. The specimens were characterized by X-ray diffraction, scanning electron microscopy, biaxial flexural strength test and 3D profilometry. In all specimens tetragonal Y2O3-ZrO2 was observed to be the main crystalline phase. The 3D profilometry indicated that alumina blasting of ZrO2 (3 mol%) increased the roughness Ra around 16–26 times as opposed to the polished surfaces, and approximately 38 times for ZrO2 (5 mol%) specimens when compared to the polished samples. The results of flexural strength indicate that groups of ZrO2 (3 mol% Y2O3) ceramics present a reduction of 21–23% from polished to alumina blasted specimens. In the group of ZrO2 (5 mol% Y2O3) ceramics, a flexural strength reduction of 37.5% was observed. A correlation between flexural strength, failure size and different roughness parameters: Ra (arithmetic average of the absolute values of the profile heights over the evaluation length), Rz (measure of the ordinates of the five highest peaks and the five deepest valleys along the specimen's length) and PV (mean values of peak and valley measured in the specimen space) is proposed and indicates that Rz and PV should not be neglected in a systematic evaluation of the surface roughness effect on the bulk mechanical properties of dental ceramics. Catholic University of Rio de Janeiro Department of Chemical and Materials Engineering PUC-Rio, Marques de São Vicente St 225, Gávea Fluminense Federal University / Faculty of Dentistry - Institute of Health of Nova Friburgo, Dr. Silvio Henrique Braune St, 22 - Downtown University of Toronto / Faculty of Dentistry, 124 Edward St #539 State University of Rio de Janeiro – Faculty of Technology, Presidente Dutra Highway, km 298 São Paulo State University - Faculty of Engineering of Guaratinguetá UNESP/FEG, Ariberto Pereira da Cunha Ave, 333 - Portal das Colinas São Paulo State University - Faculty of Engineering of Guaratinguetá UNESP/FEG, Ariberto Pereira da Cunha Ave, 333 - Portal das Colinas FAPERJ: E26-201.476/2014

International audience; A heterogeneous catalyst was assembled with ruthenium nanoparticles on carbon nanotubes and used in a mild oxidation method to prepare sulfones from sulfides. The system proved very efficient on the investigated substrates and the products were obtained in high yields.

Since its birth in the 1990s, semiconductor spintronics has suffered from poor compatibility with ferromagnets as sources of spin. While the broken inversion symmetry of some semiconductors may alternatively allow for spin-charge interconversion, its control by electric fields is volatile. Ferroelectric Rashba semiconductors stand as appealing materials unifying semiconductivity, large spin-orbit coupling, and non-volatility endowed by ferroelectricity. However, their potential for spintronics has been little explored. Here, we demonstrate the non-volatile, ferroelectric control of spin-to-charge conversion at room temperature in epitaxial GeTe films. We show that ferroelectric switching by electrical gating is possible in GeTe despite its high carrier density. We reveal a spin-to-charge conversion as effective as in Pt, but whose sign is controlled by the orientation of the ferroelectric polarization. The comparison between theoretical and experimental data suggests that spin Hall effect plays a major role for switchable conversion. These results open a route towards devices combining spin-based logic and memory integrated into a silicon-compatible material., 21 pages, 4 figures

International audience; Inflammatory bowel diseases (IBDs) constitute disturbances of gastrointestinal tract that cause irreversible changes in the structure and function of tissues. Ulcerative colitis (UC), the most frequent IBD in the population, is characterized by prominent inflammation of the human colon. Functional foods containing probiotic bacteria have been studied as adjuvants to the treatment or prevention of IBDs. The selected probiotic strain Lactococcus lactis NCDO 2118 (L. lactis NCDO 2118) exhibits immunomodulatory effects, with promising results in UC mouse model induced by dextran sodium sulfate (DSS). Additionally, cheese is a dairy food that presents high nutritional value, besides being a good delivery system that can be used to improve survival and enhance the therapeutic effects of probiotic bacteria in the host. Therefore, this work investigated the probiotic therapeutic effects of an experimental Minas Frescal cheese containing L. lactis NCDO 2118 in DSS-induced colitis in mice. During colitis induction, mice that consumed the probiotic cheese exhibited reduced in the severity of colitis, with attenuated weight loss, lower disease activity index, limited shortening of the colon length, and reduced histopathological score. Moreover, probiotic cheese administration increased gene expression of tight junctions’ proteins zo-1, zo-2, ocln, and cln-1 in the colon and increase IL-10 release in the spleen and lymph nodes. In this way, this work demonstrates that consumption of probiotic Minas Frescal cheese, containing L. lactis NCDO 2118, prevents the inflammatory process during DSS-induced colitis in mice, opening perspectives for the development of new probiotic functional foods for personalized nutrition in the context of IBD.

Reproductive seasonality may have a considerable influence on the efficiency of assisted reproductive technologies in seasonal species. This study evaluated the effect of season on cleavage, blastocyst rates and quality of in vitro produced (IVP) goat embryos. In total, 2348 cumulus–oocyte complexes (COCs) were recovered from slaughterhouse ovaries and subjected to the same IVP system throughout 1.5 years (49 replicates). The odds ratio (OR) among seasons was calculated from values of cleavage and blastocyst rates in each season. Cleavage rate was lower (p &lt, 0.05) in spring (anestrus), in comparison with either autumn (peak of breeding season) or summer, while the winter had intermediate values. Furthermore, lower OR of cleavage was observed in spring. Blastocyst formation rate (from initial number of COCs) was higher (p &lt, 0.05) in autumn (52 ± 2.5%) when compared with the other seasons (combined rates: 40 ± 1.9%). Moreover, its OR was higher (p &lt, 0.05) in autumn compared to all other seasons and impaired in the spring compared to winter (OR: 0.54) and summer (OR: 0.48). Embryo hatchability and blastocyst cell number were similar (p &gt, 0.05) among seasons. In conclusion, the breeding season leads to improved oocyte developmental competence, resulting in higher cleavage and blastocyst yield, whereas embryo quality remained similar throughout the years.

International audience; No abstract available

International audience; BACKGROUND: Gut dysbiosis is common in patients with chronic kidney disease (CKD) and is closely related to inflammatory processes. Some nutritional strategies, such as bioactive compounds present in curcumin, have been proposed as an option to modulate the gut microbiota and decrease the production of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (pCS) and indole-3 acetic acid (IAA). OBJECTIVE: To evaluate the effects of curcumin supplementation on uremic toxins plasma levels produced by gut microbiota in patients with CKD on hemodialysis (HD). METHODS: Randomized, double-blind trial in 28 patients [53.6 ± 13.4 years, fourteen men, BMI 26.7 ± 3.7 kg/m(2), dialysis vintage 37.5 (12-193) months]. Fourteen patients were randomly allocated to the curcumin group and received 100 mL of orange juice with 12 g carrot and 2.5 g of turmeric and 14 patients to the control group who received the same juice but without turmeric three times per week after HD sessions for three months. IS, pCS, IAA plasma levels were measured by reverse-phase high-performance liquid chromatography RESULTS: After three months of supplementation, the curcumin group showed a significant decrease in pCS plasma levels [from 32.4 (22.1-45.9) to 25.2 (17.9-37.9) mg/L, p = 0.009], which did not occur in the control group. No statistical difference was observed in IS and IAA levels in both groups. CONCLUSION: The oral supplementation of curcumin for three months seems to reduce p-CS plasma levels in HD patients, suggesting a gut microbiota modulation.

Made available in DSpace on 2021-06-25T11:15:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Many developing countries have highly unequal health systems across their regions. The pandemic of COVID-19 brought an additional challenge, as hospital structures equipped with doctors, intensive care units and respirators are not available to a sufficient extent in all regions. Using Data Envelopment Analysis, we create a COVID Index to verify whether the hospital structures in 543 Brazilian microregions are adequate to deal with COVID-19 and to verify whether public policies were implemented in the right direction. The results indicate that hospital structures in the poorest microregions were the most vulnerable, although the peak of COVID-19 occurred in the richest microregions (Sao Paulo). The Southeast states could relocate hospital resources or even patients between their regions. The relocation was not possible in many states in the Northeast, as the health system poorly assisted the interior of these states. These findings reveal that the heterogeneity of microregions’ hospital structures follows the patterns of socioeconomic inequalities. We conclude that it is easier for the wealthier regions to reallocate hospital resources internally than for the poorest regions. By using the COVID Index, policymakers and hospital managers have straightforward information to decide which regions must receive new investments and reallocate underutilized resources. Department of Innovation Economics University of Hohenheim, Wollgrasweg 23, 2nd floor, Room 520i Department of Economics Federal University of Ouro Preto (UFOP), Rua do Catete 166 Centro Department of Production Engineering São Paulo State University (UNESP) Núcleo Residencial Presidente Geisel, Avenida Engenheiro Luiz Edmundo Carrijo Coube, 14-01 Department of Gerontology Federal University of São Carlos (UFSCar), Rod. Washington Luiz, s/n Department of Production Engineering Federal University of São Carlos (UFSCar), Rod. Washington Luiz, s/n DST/NRF South African Chair in Industrial Development College of Business and Economics University of Johannesburg, 31 Henley Road Department of Production Engineering Fluminense Federal University (UFF), Rua Passo da Pátria, Campus Praia Vermelha, Bloco D - sala 309 Department of Production Engineering Federal University of Rio Grande do Norte (UFRN), Av. Senador Salgado Filho, n° 3000, Campus Universitário Lagoa Nova - Centro de Tecnologia Department of Production Engineering University of São Paulo (EESC/USP), Av. Trab. São Carlense, 400 - Parque Arnold Schimidt Department of Production Engineering São Paulo State University (UNESP) Núcleo Residencial Presidente Geisel, Avenida Engenheiro Luiz Edmundo Carrijo Coube, 14-01

Made available in DSpace on 2021-06-25T10:32:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Recent studies have shown that the effectiveness of establishing Marine Protected Areas (MPAs) is threatened by toxic effects of contaminants. São Paulo is the most economically developed state of Brazil, and its coast is protected by a system of MPAs, including the North Shore Marine Protected Area (NSMPA). The present study provides a first assessment of sediment quality in NSMPA and two reference sites. Concentrations of arsenic (As), metals (Al, Fe, Cd, Cr, Cu, Ni, Pb, and Zn) and polycyclic aromatic hydrocarbons (PAHs) and its sources were determined. Comparisons with sediment quality guidelines indicated low contamination, as confirmed by the Geoaccumulation Index, which classified the results as background levels. Whole-sediment exposures of the amphipod Tiburonella viscana were performed to estimate possible acute effects, but samples exhibited no toxicity. The results presented in this study represent a baseline for further monitoring programs of MPAs, supporting conservation actions of management plans. São Paulo State University (UNESP), Praça Infante Dom Henrique, s/n Institute of Marine Sciences (LABOMAR) Federal University of Ceará (UFC), Av. da Abolição, 3207 Oceanographic Institute (IOUSP) University of São Paulo (USP), Praça do Oceanográfico, 191 Department of Chemistry Federal University of Ceará (UFC), Av. Humberto Monte s/n Department of Geochemistry Fluminense Federal University (UFF) São Paulo State University (UNESP), Praça Infante Dom Henrique, s/n CAPES: 001 FAPESP: 2013/15482-0 CNPq: 308533/2018-6 CNPq: 311609/2014-7 CNPq: 455280/2014-2

International audience; No abstract available

Made available in DSpace on 2021-06-25T11:18:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Roller burnishing process is a post-machining surface finishing technique that has an advantage over other finishing processes, such as shot blasting or abrasive-tooling processes, because of its simplicity and excellent results (both improved surface finish and improving the mechanical properties of the material). Roller burnishing allows you to eliminate the part grinding step. Nickel super alloys, in turn, including the Inconel 718 have wide application in the aerospace industry due to their high fatigue strength and their ability to work at elevated temperatures. The Inconel 718 shows a predominantly austenitic matrix (γ phase), which under the burnishing process trends to produce an increase in hardness and residual stress. This paper is the result of research on the influence of the conventional roller rolling process at room temperature and at 310°C on a turned part of Inconel 718. Results of surface roughness, roundness deviation, microhardness, residual stress, and deformation of the material under a load of 850 N were analyzed. The obtained results prove the improvement of the material properties after the roller burnishing process: lower values of surface roughness, higher roundness deviation in conventional burnishing, higher surface hardness and higher compressive residual stress in hot burnished specimen. Department of Mechanical Engineering Sao Paulo State University - Unesp Department of Mechanical Engineering Fluminense Federal University - UFF Department of Mechanical Engineering Sao Paulo State University - Unesp

International audience; The present study determined i) the presence of proteins (oviduct-specific glycoprotein, OVGP1; heat shock protein-70A, HSPA1A; heat shock protein-A8, HSPA8; annexin A1, ANXA1; annexin A5, ANXA5; and myosin-9, MYH9) known to be involved in early reproduction in the oviduct fluid (OF) of anestrous goats; and ii) the functional effect of during IVF on polyspermy modulation and embryonic development. In vitro-matured oocytes were co-cultured with spermatozoa (1.0, 2.0, or 4.0 x 106 cells/mL) for 18 h in SOF medium supplemented with 5 mg/mL of heparin, 4 mg/mL gentamicin, and 10% estrus sheep serum (CTRL1, CTRL2, and CTRL4 groups) or the same medium plus 10% OF (OF1, OF2, and OF4 groups) obtained from anestrus goats. The analysis of OF by western blotting confirmed the presence of the six proteins tested for. The increase in sperm concentration had no effect (P > 0.05) on the penetration rate in any group; however, monospermy rate decreased as sperm concentration was increased in both OF and CTRL. Regardless of the concentration used, when data were pooled, OF supplementation improved (P < 0.05) monospermy and tended (P 0.057) to enhance IVF efficiency. Additionally, IVF efficiency was higher (P < 0.05) in OF1 than in OF4 [60 +/- 13 vs 37 +/- 5%). The development capacity was not affected (P > 0.05) by the sperm concentration and OF treatment, and the average values were cleavage (72 +/- 2.6%), blastocyst (37 +/- 3.0%), blastocyst in relation to the cleaved (51 +/- 4.8%), hatched (62 +/- 1.2%), and number of cells per blastocyst (174 +/- 1.8%). In conclusion, the six proteins analyzed are present in the OF of anestrous goats, and the supplementation of this OF during IVF may modulate the polyspermy incidence and enhance IVF efficiency, especially when 1x10(6) sperm per mL is used.

Methylmercury (MeHg+) is a mercury species that is very toxic for humans, and its monitoring and sorption from environmental samples of water are a public health concern. In this work, a combination of theory and experiment was used to rationally synthesize an ion-imprinted polymer (IIP) with the aim of the extraction of MeHg+ from samples of water. Interactions among MeHg+ and possible reaction components in the pre-polymerization stage were studied by computational simulation using density functional theory. Accordingly, 2-mercaptobenzimidazole (MBI) and 2-mercaptobenzothiazole (MBT), acrylic acid (AA) and ethanol were predicted as excellent sulfhydryl ligands, a functional monomer and porogenic solvent, respectively. Characterization studies by scanning electron microscopy (SEM) and Brunauer&ndash, Emmett&ndash, Teller (BET) revealed the obtention of porous materials with specific surface areas of 11 m2 g&minus, 1 (IIP&ndash, MBI&ndash, AA) and 5.3 m2 g&minus, MBT&ndash, AA). Under optimized conditions, the maximum adsorption capacities were 157 &micro, g g&minus, 1 (for IIP&ndash, AA) and 457 &micro, AA). The IIP&ndash, AA was selected for further experiments and application, and the selectivity coefficients were MeHg+/Hg2+ (0.86), MeHg+/Cd2+ (260), MeHg+/Pb2+ (288) and MeHg+/Zn2+ (1510), highlighting the material&rsquo, s high affinity for MeHg+. The IIP was successfully applied to the sorption of MeHg+ in river and tap water samples at environmentally relevant concentrations.

AIM: The ‘abundant centre’ hypothesis states that species are more abundant at the centre of their range. However, several recent large‐scale studies have failed to find evidence for such a pattern. Here we used extensive global data of reef fishes to test the ‘abundant centre’ pattern, and to examine variation in the abundance patterns across species using life history and ecological traits. LOCATION: Marine habitat at a global extent: from Indo‐Pacific to Atlantic reefs. METHODS: We used underwater visual estimates of fish abundance, containing 22,963 transects and 1,215 species. For each species we calculated the slope between abundance and distance to the range centre, with the range centre estimated using four different methods. We tested whether abundance patterns differ between the range core and margins using segmented regression. Meta‐analytic methods were used to synthesize results across species, and to test whether species traits can explain variation in the fit to the pattern among species. RESULTS: The method used to define the range centre had a large effect on the results. Nevertheless, in all cases we found large variation between species. Results of the segmented regression revealed that changes in abundance across the range core are very small and that steep declines in abundance happen only towards the range margins. Body size and mean abundance were the main traits affecting the fit to the pattern across species. MAIN CONCLUSIONS: We find large variation across species in the fit to the abundance centre pattern. Nevertheless, we do find support for a general pattern of a range core with high, but variable, abundance and steep decline in abundance towards the range periphery. Thus, species do tend to be rare at the range margins, making them sensitive to extirpation due to both natural and anthropogenic impacts.

Made available in DSpace on 2020-12-12T02:47:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) Financiadora de Estudos e Projetos The present work reports the use of spectroscopic ellipsometry to study the properties of molecularly imprinted poly(ortho-phenylenediamine) film. This polymer was electrosynthesized by cyclic voltammetry and applied for the detection of hexahydrofarnesol, which is the main contaminant of aviation biokerosene. Ellipsometry was used to obtain the thickness of the polymeric film and to investigate the optical and dielectric properties of this material. The results obtained showed that the optical properties and dielectric constants of the molecularly imprinted polymer were sensitive to the presence or absence of the hexahydrofarnesol molecule. Detection studies for this molecule showed that the modified electrode responds linearly in two distinct concentration ranges: 5.0 × 10−8 to 1.3 × 10−7 mol L−1 and 3.0 × 10−7 to 1.5 × 10−6 mol L−1, with the first linear range presenting a sensitivity 27.3 times higher than the second range. This is in line with the behavior of the optical properties (refractive index and extinction coefficient) of the polymeric film, which pointed to the presence of a larger number of imprinted cavities in the non-homogeneous part of the polymer. Essentially, this study proved that, apart from measuring film thickness, spectroscopic ellipsometry is a powerful tool for the characterization of molecularly imprinted polymers. Institute of Chemistry São Paulo State University (UNESP), São Paulo Bioenergy Research Institute São Paulo State University (UNESP), São Paulo Institute of Exact Sciences Fluminense Federal University (UFF), Volta Redonda, Rio de Janeiro School of Industrial Metallurgical Engineering Fluminense Federal University (UFF), Volta Redonda, Rio de Janeiro Institute of Chemistry São Paulo State University (UNESP), São Paulo Bioenergy Research Institute São Paulo State University (UNESP), São Paulo

Part 4: Inclusion and Participation; International audience; Although the Brazilian “Bolsa Família” Program (BFP) was largely discussed due to its economic and social outcomes, little is known about the Information Systems (IS) that support BFP. In the context of BFP, CadÚnico system emerged as the registry for citizens who seek to qualify for BFP income transfers, as well as it is an important source of information for other public policies. This paper presents a case study of BFP’s evolution over decades through the CadÚnico development. We analyze how the CadÚnico system evolved in Brazil from a fragmented, offline databases in the early 2000 to a unified, online registry essential to BFP operation. Based on enrolment operations, the paper explains how CadÚnico first attracted other ministries from the Federal Government and later attracted municipalities to data registering. By analyzing BFP IS, we bring more evidences to the political and incremental nature of IS development in developing countries.

Made available in DSpace on 2020-12-12T02:36:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Downhole Safety Valve (DHSV) stands for a device widely used in offshore wells to ensure the integrity and avoid uncontrolled leaks of oil and gas to the environment, known as blowouts. The reliability estimation of such valves can be used to predict the blowout occurrence and to evaluate the workover demand, as well as to assist decision-making actions. In this paper, we introduce FEMaR, a Finite Element Machine for regression problems, which figures no training step, besides being parameterless. Another main contribution of this work is to evaluate several machine learning models to estimate the reliability of DHSVs for further comparison against traditional statistical methods. The experimental evaluation over a dataset collected from a Brazilian oil and gas company showed that machine learning techniques are capable of obtaining promising results, even in the presence of censored information, and they can outperform the statistical approaches considered in this work. Such findings also investigated using uncertainty analysis, evidenced that we can save economic resources and increase the safety at the offshore well operations. CENPES/PETROBRAS, Rio de Janeiro Department of Production Engineering Fluminense Federal University University of Western São Paulo, Presidente Prudente Department of Computing São Paulo State University - UNESP Department of Computing São Paulo State University - UNESP FAPESP: 2013/07375-0, 2014/12236-1 FAPESP: 2016/19403-6

This paper presents a microstrip phased array using High Impedance Surface - Electromagnetic Bandgap (HIS-EBG) in order to minimize the effects of mutual coupling among the antenna elements. Each element of the array is fed by a coaxial cable allowing the beam steering by controlling the signal of the input port of each element. This phased array operates at X Band as well as the bandgap of the HIS-EBG structure. Its main applications are satellite communication and broadcasting systems. Results show reductions in the mutual coupling up to 12 dB, and improvements in the return loss and gain.

WOS:000519752500001; International audience; Unraveling new environmentally friendly antifouling (AF) agents is one of the major quests currently facing marine biotechnology. Marine macroalgae represent a rich source of new compounds with promising biological properties, including AF activity, but most of the macroalgal compounds studied to date are terpenoids or polyphenolics. The aim of this work was to investigate the possible AF role played by a usually neglected class of marine natural products: glycolipids (monogalactosyldiacylglycerols - MGDG, digalactosyldiacylglycerols - DGDG and sulfoquinovosyldiacylglycerols - SQDG) isolated from the Phaeophyceae Sargassum vulgare collected along the coast of south-eastern Brazil. Among the 18 extracts, fractions and sub-fractions tested, 3 subfractions demonstrated particularly promising AF activity toward the growth inhibition of marine bacteria and microalgae: F3III117, F4II70a, and F4II70b. The main compounds present in these fractions were identified as MGDG, DGDG, and SQDG, respectively. These results highlight the potential of glycoglycerolipids from S. vulgare as new promising antifouling agents.

Cities are constantly transforming and, consequently, attracting efforts from researchers and opportunities to the industry. New transportation systems are being built in order to meet sustainability and efficiency criteria, as well as being adapted to the current possibilities. Moreover, citizens are becoming aware about the power and possibilities provided by the current generation of autonomous devices. In this sense, this paper presents and discusses state-of-the-art transportation technologies and systems, highlighting the advances that the concepts of Internet of Things and Value are providing. Decentralized technologies, such as blockchain, are been extensively investigated by the industry, however, its widespread adoption in cities is still desirable. Aligned with operations research opportunities, this paper identifies different points in which cities&rsquo, services could move to. This also study comments about different combinatorial optimization problems that might be useful and important for an efficient evolution of our cities. By considering different perspectives, didactic examples are presented with a main focus on motivating decision makers to balance citizens, investors and industry goals and wishes.

Made available in DSpace on 2020-12-12T02:26:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-15 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) This paper report the development of a new HPLC-pulsed amperometric detector (HPLC-PAD) for the determination of antioxidants using glass carbon electrode (GCE) modified with reduced graphene oxide (rGO) and gold nanoparticles (AuNPs). The modified electrode exhibited efficient electro-oxidation when it was applied in the analysis of three important antioxidants: N, N'-di-sec-butyl paraphenylenediamine (BPA), 2,6-Di-tert-butylphenol (TBP) and 2,6-Di-tert-butyl-4-methylphenol (BHT). The chromatographic separation was performed with an isocratic elution composed of acetonitrile/water (90:10% v/v) and 1% acetic acid. The chromatograms showed good separation of all components in periods of time less than 10 min. The developed method presented linear ranges of 5.0 × 10−6–1.3 × 10−4 mol L−1 (BPA), 2.5 × 10−6–1.0 × 10−4 mol L−1 (TBP) and 7.5 × 10−7–1.3 × 10−4 mol L−1 (BHT), and the analytical curves presented limits of detection of 1.2 × 10−7, 1.7 × 10−7 and 7.8 × 10−8 mol L−1 for BPA, TBP and BHT, respectively. The values obtained for the recovery studies conducted ranged from 97.3 ± 1.5% to 101.5 ± 2.1%. The results showed that the method is reliable, since it presented high sensitivity, precision and accuracy. The developed method was successfully applied for the determination of antioxidants in a sample of biokerosene, consisting of isoparaffins synthesized from fermented and hydroprocessed sugars. The determined concentrations were TBP 3.1 × 10−5 ± 5.5 × 10−6 mol L−1 and BHT 3.3 × 10−5 ± 2.9 × 10−6 mol L−1. Chemistry Institute São Paulo State University (UNESP) Department of Chemical Technology Federal University of Maranhão (UFMA) Bioenergy Research Institute São Paulo State University (UNESP) School of Industrial and Metallurgical Engineering Fluminense Federal University (UFF) Chemistry Institute São Paulo State University (UNESP) Bioenergy Research Institute São Paulo State University (UNESP) FAPESP: 2017/25329-6

International audience; The Amazon Fan provides a natural laboratory to study the generation of overpressure, due to rapid late Cenozoic burial that has resulted in gravitational collapse above shale detachments. Here we examine collapse systems for the first time using the techniques of petroleum systems analysis. We propose an integrated methodology based on numerical modeling constrained by the structural restoration of a seismic profile across the southwestern fan. The results provide information on the evolution of pore pressure and temperature and their implications for the operation of the detachment and overlying extensional and compressional faults during the deposition of up to 6 km of sediment over the last 8 Ma. The modelled thermal history implies that fluid release by smectite-to-illite transformation has taken place within the thickening sedimentary succession, but has not significantly contributed to pore pressures along the detachment. Modeling of hydrocarbon generation and migration from source rocks beneath the fan indicates gas accumulated in successions at depths of 102–103 m beneath the detachment without influencing pore pressures along it. In contrast, model results indicate that overpressures have varied in response to disequilibrium compaction. Fault activity within the collapse system took place during phases of higher sedimentation rates, and ceased from 5.5 to 3.7 Ma when sediment supply to the SE fan decreased. From 2 Ma, renewed sediment flux and shelf-slope progradation led to a basinward migration both of overpressure along the detachment and of fault activity above it. We conclude that gravity tectonics in the Amazon Fan over the last 8 Ma have been mainly controlled by overpressures due to disequilibrium compaction, with secondary contributions from clay mineral transformation. Present-day pressure conditions show that the southeastern Amazon Fan is not at equilibrium and gravity driven deformation could occur at any time.

Part 3: Open Data: Social and Technical Aspects; International audience; Public administration is one of the largest producers and collectors of data in several domains. Bearing in mind that one of the main pillars of public transparency is the release of social value through government data, and that this right remains a challenge for citizens, in this work we implemented a methodology that uses techniques and Answers and Information Retrieval to retrieve data sets and respond to questions from citizens on a Brazilian open government data portal. Using metrics of information retrieval evaluation, such as accuracy and recall, we obtained satisfactory results in applying the proposed methodology.

International audience; Inflammatory and innate immune responses triggered by pathogen-associated and other danger-associated signals emerging during infections, results in the activation of cytosolic inflammasomes. The nod-like receptor pyrin domain containing 3 (NLRP3) is one of the inflammasomes mediating such responses through the activation of caspase-1, which increases the production and release of pro-inflammatory cytokines, such as IL-1β and IL-18 and induces programmed cell death through pyroptosis. NLRP3 is thought to play a crucial role in the underlying inflammatory responses in many lifestyles related chronic diseases. Consequently, research on the NLRP3 inflammasome has expanded dramatically in recent years. Although several studies have investigated the role of NLRP3 activation in chronic kidney disease (CKD), few studies have evaluated strategies to modulate its activation by means of interventions using non-pharmacological strategies. This review discusses some nutritional strategies (bioactive compounds, probiotics and caloric restriction) that have been shown to influence NLRP3 in experimental models of renal disease, and in CKD. It discusses how nutritional interventions could potentially dampen NLRP3 associated inflammatory burden, as part of nutritional strategies to prevent and treat CKD and its complications.

International audience; In this work we analyse preference atmospheres, investigating attractiveness and affectivity in conflict and vulnerability territories located in peripheral urban areas. Preference atmospheres are conceptions of world that contemplate multiple meanings attribution. This conceptualization is based on various studies, whose dialogues enabled a methodology development that has been applied, in this work, in the Manguinhos favela complex – the ‘Carioca Gaza Strip’, located in Rio de Janeiro’s North Zone. Our analysis focuses on the so-called ‘Marcelo Square’, a small square constructed by local residents in a prohibited area, and Estrada de Manguinhos Street, symbolic open spaces of affectivity and attractiveness in an area widely known for its socio-environmental vulnerability.

Made available in DSpace on 2022-04-29T08:40:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-01 This study aimed to compare two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting. The immunolabeling of cells for RUNX2 and VEGF were performed to evaluate the osteoblast precursor cells and the vascular formation after 6 months of bone repair. Ten maxillary sinuses were grafted with autogenous bone graft (Group 1), 10 were grafted with ChronOs® (Group 2), and 10 were grafted with BETA-TCP® (Group 3). After 6 months of bone healing, biopsies were obtained to assess the new bone formed by histomorphometric and immunohistochemical evaluation for RUNX2 and VEGF. The mean bone formation for Group 1 was 51.4 ± 17.4%. Group 2 presented 45.5 ± 9.9%, and Group 3 conferred 35.4 ± 8.0% of new bone formation. The RUNX2 offered low for Groups 1 and 2 with high cellular activity for osteoblast in Group 3. The VEGF immunolabeling was moderate for Groups 1 and 2 and intense for Group 3. In conclusion, it was possible to show that the bone substitutes evaluated in the present study presented suitable outcomes for bone regeneration, being an alternative for the autogenous bone graft in maxillary sinus bone height reconstruction. Department of Oral & Maxillofacial Surgery Aracatuba School of Dentistry Sao Paulo State University Department of Oral & Maxillofacial Surgery University of Grande Rio—UNIGRANRIO Clinical Research Unit of the Antonio Pedro Hospital Fluminense Federal University Department of Dental Prosthesis Aracatuba School of Dentistry Sao Paulo State University Department of Human Anatomy Aracatuba School of Dentistry Sao Paulo State University Department of Oral & Maxillofacial Surgery Aracatuba School of Dentistry Sao Paulo State University Department of Dental Prosthesis Aracatuba School of Dentistry Sao Paulo State University Department of Human Anatomy Aracatuba School of Dentistry Sao Paulo State University

The origin of modern disjunct plant distributions in the Brazilian Highlands with strong floristic affinities to distant montane rainforests of isolated mountaintops in the northeast and northern Amazonia and the Guyana Shield remains unknown. We tested the hypothesis that these unexplained biogeographical patterns reflect former ecosystem rearrangements sustained by widespread plant migrations possibly due to climatic patterns that are very dissimilar from present-day conditions. To address this issue, we mapped the presence of the montane arboreal taxa Araucaria, Podocarpus, Drimys, Hedyosmum, Ilex, Myrsine, Symplocos, and Weinmannia, and cool-adapted plants in the families Myrtaceae, Ericaceae, and Arecaceae (palms) in 29 palynological records during Heinrich Stadial 1 Event, encompassing a latitudinal range of 30°S to 0°S. In addition, Principal Component Analysis and Species Distribution Modelling were used to represent past and modern habitat suitability for Podocarpus and Araucaria. The data reveals two long-distance patterns of plant migration connecting south/southeast to northeastern Brazil and Amazonia with a third short route extending from one of them. Their paleofloristic compositions suggest a climatic scenario of abundant rainfall and relative lower continental surface temperatures, possibly intensified by the effects of polar air incursions forming cold fronts into the Brazilian Highlands. Although these taxa are sensitive to changes in temperature, the combined pollen and speleothems proxy data indicate that this montane rainforest expansion during Heinrich Stadial 1 Event was triggered mainly by a less seasonal rainfall regime from the subtropics to the equatorial region., This work was funded by FAPESP research grant 2015/50683-2 to P.E. De Oliveira, VULPES Project, Belmount Forum.

Made available in DSpace on 2022-04-28T19:45:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01 The generation of waste electrical and electronic equipment (WEEE) has become a globally serious problem. Its adequate management has great importance for governments and organizations alike. Despite the available literature on models for estimating WEEE generation, such analysis and forecasting are scarce in the context of big organizations. The objective of this research is to estimate WEEE generation in organizations using the Market Supply model applied to a Brazilian federal agency. The agency's Asset Control System was the data source. These records allow organizations to effectively manage their WEEE, influencing the quality of generation estimate. A statistical analysis was carried to calculate the lifespan of the equipment in the system, observing a reduction in the lifespan of the most modern items. The model allows for estimating WEEE generation for the coming years in organizations, whilst providing lifespan profiles, meaning the probabilistic obsolescence rate of appliances. The results obtained, including the statistical analyses and the used methodology represent a valuable resource to organizations as a means to inform their decision-making process regarding the management of WEEE. National Commission for Nuclear Energy (CNEN), Rua General Severiano, 90. Botafogo Department of Environmental Engineering Institute of Science and Technology São Paulo State University (Unesp), Rodovia Presidente Dutra, Km 137.8 Production Engineering School Fluminense Federal University (UFF), Rua Passo da Pátria, 156. São Domingos Nuclear Technology Development Center (CDTN) National Commission for Nuclear Energy (CNEN), Avenida Presidente Antônio Carlos, 6.627, Campus da UFMG, Pampulha Department of Environmental Engineering Institute of Science and Technology São Paulo State University (Unesp), Rodovia Presidente Dutra, Km 137.8