1. Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040
- Author
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Leonie Pellissier, Hai Deng, Marcel Jaspars, Eva C. Sonnenschein, Bruce F. Milne, Jioji N. Tabudravu, Daniëlle Copmans, Espen Hansen, Jeanette Hammer Andersen, Kine Østnes Hanssen, Mercedes de la Cruz, Lone Gram, Venke Kristoffersen, José R. Tormo, Stephan Goralczyk, Floriane M. Vabre, Rainer Ebel, Marc Stierhof, Peter de Witte, Caridad Díaz, [Sonnenschein, Eva C.] Tech Univ Denmark, Dept Biotechnol & Biomed, Matematiktorvet 301, DK-2800 Lyngby, Denmark, [Gram, Lone] Tech Univ Denmark, Dept Biotechnol & Biomed, Matematiktorvet 301, DK-2800 Lyngby, Denmark, [Stierhof, Marc] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Goralczyk, Stephan] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Vabre, Floriane M.] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Pellissier, Leonie] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Ebel, Rainer] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Jaspars, Marcel] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Tabudravu, Jioji N.] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [de Witte, Peter] Dept Pharmaceut & Pharmacol Sci, Lab Mol Biodiscovery, KU Leuven Campus,O&N 2 Herestr 49,Box 824, B-3000 Leuven, Belgium, [Copmans, Danielle] Dept Pharmaceut & Pharmacol Sci, Lab Mol Biodiscovery, KU Leuven Campus,O&N 2 Herestr 49,Box 824, B-3000 Leuven, Belgium, [Hanssen, Kine Ostnes] UiT Arctic Univ Norway, Marbio, Tromso, Norway, [Andersen, Jeanette Hammer] UiT Arctic Univ Norway, Marbio, Tromso, Norway, [Hansen, Espen] UiT Arctic Univ Norway, Marbio, Tromso, Norway, [Kristoffersen, Venke] UiT Arctic Univ Norway, Marbio, Tromso, Norway, [de la Cruz, Mercedes] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Ave Conocimiento 34,Parque Tecnol Ciencias Salud, Granada 18016, Spain, [Diaz, Caridad] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Ave Conocimiento 34,Parque Tecnol Ciencias Salud, Granada 18016, Spain, [Tormo, Jose R.] Fdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Ave Conocimiento 34,Parque Tecnol Ciencias Salud, Granada 18016, Spain, [Milne, Bruce F.] Univ Coimbra, Dept Phys, CFisUC, Rua Larga, P-3004516 Coimbra, Portugal, EU seventh Framework Programme Project 'PharmaSea', Portuguese Foundation for Science and Technology, DIPC, CFM (UPV/EHU), and Laboratory for Advanced Computation (University of Coimbra)
- Subjects
0301 basic medicine ,Mycobacterium-tuberculosis ,030106 microbiology ,F100 ,Microorganisms ,Siderocalin ,Library science ,010402 general chemistry ,01 natural sciences ,Biochemistry ,03 medical and health sciences ,LCMS ,Siderophore ,Drug Discovery ,Vibrio-cholerae ,Pseudomonas-aeruginosa ,Pyochelin ,Microbial iron transport ,biology ,Chemistry ,Organic Chemistry ,biology.organism_classification ,NMR ,Coordination chemistry ,0104 chemical sciences ,3. Good health ,Recognition ,Pseudoalteromonas ,Acquisition ,Pseudoalteromonas piscicida ,Pseudochelin A - Abstract
A new siderophore containing a 4,5-dihydroimidazole moiety was isolated from Pseudoalteromonas piscicida S2040 together with myxochelins A and B, alteramide A and its cycloaddition product, and bromo- and dibromoalterochromides. The structure of pseudochelin A was established by spectroscopic techniques including 2D NMR and MS/MS fragmentation data. In bioassays selected fractions of the crude extract of S2040 inhibited the opportunistic pathogen Pseudomonas aeruginosa. Pseudochelin A displayed siderophore activity in the chrome azurol S assay at concentrations higher than 50 mu M, and showed weak activity against the fungus Aspergillus fumigatus, but did not display antibacterial, anti-inflammatory or anticonvulsant activity. (C) 2017 Elsevier Ltd. All rights reserved.
- Published
- 2017
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