1. Cardiovascular disease in patients with spondyloarthropathies
- Author
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Jean Christophe Cornily, Patrick Godon, Alain Saraux, Florence Arlès, Aurore Brondex, Jacques Mansourati, Gilles Quiniou, Ulric Vinsonneau, Département de Cardiologie (HIA - Cardio), Hôpital d'Instruction des armées, Optimisation des régulations physiologiques (ORPHY (EA 4324)), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Service de Cardiologie, Brest, and Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST )
- Subjects
MESH: Antirheumatic Agents ,Pathology ,MESH: Cyclooxygenase 2 Inhibitors ,Spondyloarthropathy ,Heart Valve Diseases ,MESH: Comorbidity ,Comorbidity ,Disease ,030204 cardiovascular system & hematology ,Risk profile ,MESH: Atherosclerosis ,MESH: Heart Conduction System ,Lactones ,0302 clinical medicine ,Risk Factors ,MESH: Risk Factors ,Medicine ,Sulfones ,Atrioventricular Block ,HLA-B27 Antigen ,Smoking ,MESH: Genetic Predisposition to Disease ,MESH: Sulfones ,3. Good health ,Cardiovascular Diseases ,Antirheumatic Agents ,MESH: Lactones ,MESH: Spondylarthropathies ,MESH: Smoking ,medicine.medical_specialty ,Susceptibility gene ,03 medical and health sciences ,Rheumatology ,Heart Conduction System ,MESH: Atrioventricular Block ,Internal medicine ,[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,Humans ,Genetic Predisposition to Disease ,In patient ,Cardiovascular mortality ,030203 arthritis & rheumatology ,MESH: Humans ,Cyclooxygenase 2 Inhibitors ,Tumor Necrosis Factor-alpha ,business.industry ,MESH: Cardiovascular Diseases ,MESH: Heart Valve Diseases ,Atherosclerosis ,medicine.disease ,Increased risk ,MESH: Tumor Necrosis Factor-alpha ,Spondylarthropathies ,MESH: HLA-B27 Antigen ,business - Abstract
International audience; Spondyloarthropathies are associated with a greater cardiovascular risk than expected based on the cardiac lesions known to occur in these diseases. The prevalence of several conventional risk factors is high in spondyloarthropathy patients, and chronic inflammation also contributes to premature plaque formation. In addition, susceptibility genes for spondyloarthropathies may be associated with an increased risk of cardiovascular disease. Finally, several drugs used to treat spondyloarthropathies may contribute to the occurrence of cardiovascular events. A careful evaluation of the cardiovascular risk profile is a key component of the management of patients with spondyloarthropathies.
- Published
- 2008
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