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1. Science Requirements and Detector Concepts for the Electron-Ion Collider: EIC Yellow Report

Author: Khalek, R. Abdul, Accardi, A., Adam, J., Adamiak, D., Akers, W., Albaladejo, M., Al-bataineh, A., Alexeev, M. G., Ameli, F., Antonioli, P., Armesto, N., Armstrong, W. R., Arratia, M., Arrington, J., Asaturyan, A., Asai, M., Aschenauer, E. C., Aune, S., Avagyan, H., Gayoso, C. Ayerbe, Azmoun, B., Bacchetta, A., Baker, M. D., Barbosa, F., Barion, L., Barish, K. N., Barry, P. C., Battaglieri, M., Bazilevsky, A., Behera, N. K., Benmokhtar, F., Berdnikov, V. V., Bernauer, J. C., Bertone, V., Bhattacharya, S., Bissolotti, C., Boer, D., Boglione, M., Bondì, M., Boora, P., Borsa, I., Bossù, F., Bozzi, G., Brandenburg, J. D., Brei, N., Bressan, A., Brooks, W. K., Bufalino, S., Bukhari, M. H. S., Burkert, V., Buttimore, N. H., Camsonne, A., Celentano, A., Celiberto, F. G., Chang, W., Chatterjee, C., Chen, K., Chetry, T., Chiarusi, T., Chien, Y. -T., Chiosso, M., Chu, X., Chudakov, E., Cicala, G., Cisbani, E., Cloet, I. C., Cocuzza, C., Cole, P. L., Colella, D., Collins II, J. L., Constantinou, M., Contalbrigo, M., Contin, G., Corliss, R., Cosyn, W., Courtoy, A., Crafts, J., Cruz-Torres, R., Cuevas, R. C., D'Alesio, U., Torre, S. Dalla, Das, D., Dasgupta, S. S., Da Silva, C., Deconinck, W., Defurne, M., DeGraw, W., Dehmelt, K., Del Dotto, A., Delcarro, F., Deshpande, A., Detmold, W., De Vita, R., Diefenthaler, M., Dilks, C., Dixit, D. U., Dulat, S., Dumitru, A., Dupré, R., Durham, J. M., Echevarria, M. G., Fassi, L. El, Elia, D., Ent, R., Esha, R., Ethier, J. J., Evdokimov, O., Eyser, K. O., Fanelli, C., Fatemi, R., Fazio, S., Fernandez-Ramirez, C., Finger, M., Finger Jr., M., Fitzgerald, D., Flore, C., Frederico, T., Friščić, I., Fucini, S., Furletov, S., Furletova, Y., Gal, C., Gamberg, L., Gao, H., Garg, P., Gaskell, D., Gates, K., Ducati, M. B. Gay, Gericke, M., da Silveira, G. Gil, Girod, F. -X., Glazier, D. I., Gnanvo, K., Goncalves, V. P., Gonella, L., Hernandez, J. O. Gonzalez, Goto, Y., Grancagnolo, F., Greiner, L. C., Guryn, W., Guzey, V., Hatta, Y., Hattawy, M., Hauenstein, F., He, X., Hemmick, T. K., Hen, O., Heyes, G., Higinbotham, D. W., Blin, A. N. Hiller, Hobbs, T. J., Hohlmann, M., Horn, T., Hou, T. -J., Huang, J., Huang, Q., Huber, G. M., Hyde, C. E., Iakovidis, G., Ilieva, Y., Jacak, B. V., Jacobs, P. M., Jadhav, M., Janoska, Z., Jentsch, A., Jezo, T., Jing, X., Jones, P. G., Joo, K., Joosten, S., Kafka, V., Kalantarians, N., Kalicy, G., Kang, D., Kang, Z. B., Kauder, K., Kay, S. J. D., Keppel, C. E., Kim, J., Kiselev, A., Klasen, M., Klein, S., Klest, H. T., Korchak, O., Kostina, A., Kotko, P., Kovchegov, Y. V., Krelina, M., Kuleshov, S., Kumano, S., Kumar, K. S., Kumar, R., Kumar, L., Kumerički, K., Kusina, A., Kutak, K., Lai, Y. S., Lalwani, K., Lappi, T., Lauret, J., Lavinsky, M., Lawrence, D., Lednicky, D., Lee, C., Lee, K., Lee, S. H., Levorato, S., Li, H., Li, S., Li, W., Li, X., Li, W. B., Ligonzo, T., Liu, H., Liu, M. X., Liu, X., Liuti, S., Liyanage, N., Lorcé, C., Lu, Z., Lucero, G., Lukow, N. S., Lunghi, E., Majka, R., Makris, Y., Mandjavidze, I., Mantry, S., Mäntysaari, H., Marhauser, F., Markowitz, P., Marsicano, L., Mastroserio, A., Mathieu, V., Mehtar-Tani, Y., Melnitchouk, W., Mendez, L., Metz, A., Meziani, Z. -E., Mezrag, C., Mihovilovič, M., Milner, R., Mirazita, M., Mkrtchyan, H., Mkrtchyan, A., Mochalov, V., Moiseev, V., Mondal, M. M., Morreale, A., Morrison, D., Motyka, L., Moutarde, H., Camacho, C. Muñoz, Murgia, F., Murray, M. J., Musico, P., Nadel-Turonski, P., Nadolsky, P. M., Nam, J., Newman, P. R., Neyret, D., Nguyen, D., Nocera, E. R., Noferini, F., Noto, F., Nunes, A. S., Okorokov, V. A., Olness, F., Osborn, J. D., Page, B. S., Park, S., Parker, A., Paschke, K., Pasquini, B., Paukkunen, H., Paul, S., Pecar, C., Pegg, I. L., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Petriello, F., Petti, R., Pilloni, A., Pinkenburg, C., Pire, B., Pisano, C., Pitonyak, D., Poblaguev, A. A., Polakovic, T., Posik, M., Potekhin, M., Preghenella, R., Preins, S., Prokudin, A., Pujahari, P., Purschke, M. L., Pybus, J. R., Radici, M., Rajput-Ghoshal, R., Reimer, P. E., Rinaldi, M., Ringer, F., Roberts, C. D., Rodini, S., Rojo, J., Romanov, D., Rossi, P., Santopinto, E., Sarsour, M., Sassot, R., Sato, N., Schenke, B., Schmidke, W. B., Schmidt, I., Schmidt, A., Schmookler, B., Schnell, G., Schweitzer, P., Schwiening, J., Scimemi, I., Scopetta, S., Segovia, J., Seidl, R., Sekula, S., Semenov-Tian-Shanskiy, K., Shao, D. Y., Sherrill, N., Sichtermann, E., Siddikov, M., Signori, A., Singh, B. K., Širca, S., Slifer, K., Slominski, W., Sokhan, D., Sondheim, W. E., Song, Y., Soto, O., Spiesberger, H., Stasto, A. M., Stepanov, P., Sterman, G., Stevens, J. R., Stewart, I. W., Strakovsky, I., Strikman, M., Sturm, M., Stutzman, M. L., Sullivan, M., Surrow, B., Svihra, P., Syritsyn, S., Szczepaniak, A., Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. S., Takaki, J. D. Tapia, Tassielli, G. F., Terry, J., Tessarotto, F., Tezgin, K., Tomasek, L., Acosta, F. Torales, Tribedy, P., Tricoli, A., Triloki, Tripathi, S., Trotta, R. L., Tsai, O. D., Tu, Z., Tuvè, C., Ullrich, T., Ungaro, M., Urciuoli, G. M., Valentini, A., Vancura, P., Vandenbroucke, M., Van Hulse, C., Varner, G., Venugopalan, R., Vitev, I., Vladimirov, A., Volpe, G., Vossen, A., Voutier, E., Wagner, J., Wallon, S., Wang, H., Wang, Q., Wang, X., Wei, S. Y., Weiss, C., Wenaus, T., Wennlöf, H., Wickramaarachchi, N., Wikramanayake, A., Winney, D., Wong, C. P., Woody, C., Xia, L., Xiao, B. W., Xie, J., Xing, H., Xu, Q. H., Zhang, J., Zhang, S., Zhang, Z., Zhao, Z. W., Zhao, Y. X., Zheng, L., Zhou, Y., and Zurita, P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment, Nuclear Theory
Abstract: This report describes the physics case, the resulting detector requirements, and the evolving detector concepts for the experimental program at the Electron-Ion Collider (EIC). The EIC will be a powerful new high-luminosity facility in the United States with the capability to collide high-energy electron beams with high-energy proton and ion beams, providing access to those regions in the nucleon and nuclei where their structure is dominated by gluons. Moreover, polarized beams in the EIC will give unprecedented access to the spatial and spin structure of the proton, neutron, and light ions. The studies leading to this document were commissioned and organized by the EIC User Group with the objective of advancing the state and detail of the physics program and developing detector concepts that meet the emerging requirements in preparation for the realization of the EIC. The effort aims to provide the basis for further development of concepts for experimental equipment best suited for the science needs, including the importance of two complementary detectors and interaction regions. This report consists of three volumes. Volume I is an executive summary of our findings and developed concepts. In Volume II we describe studies of a wide range of physics measurements and the emerging requirements on detector acceptance and performance. Volume III discusses general-purpose detector concepts and the underlying technologies to meet the physics requirements. These considerations will form the basis for a world-class experimental program that aims to increase our understanding of the fundamental structure of all visible matter, Comment: 902 pages, 415 authors, 151 institutions
Published: 2021
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2. Process dependence of the gluon Sivers function in inclusive $pp$ collisions: phenomenology

Author: D'Alesio, U., Flore, C., Murgia, F., Pisano, C., and Taels, P.
Subjects: High Energy Physics - Phenomenology
Abstract: Within the so-called color gauge invariant generalized parton model, a TMD scheme including initial- (ISI) and final-state (FSI) interactions, we present a phenomenological analysis of available SSA data for pion and $D$-meson production in $pp$ collisions. This allows us, for the first time, to put a preliminary constraint on the two universal types of gluon Sivers function entering the model. Predictions for SSAs in $J/\psi$ and direct photon production, as well as a comparison with the simpler generalized parton model (without ISIs and FSIs), are also presented., Comment: 7 pages, 6 figures (11 plots); to appear in the Proceedings of the 23rd International SPIN Symposium (SPIN 2018), Ferrara, Italy, September 10-14, 2018
Published: 2019

3. Assessing signals of TMD physics in SIDIS azimuthal asymmetries and in the extraction of the Sivers function

Author: Boglione, M., D'Alesio, U., Flore, C., and Gonzalez-Hernandez, J. O.
Subjects: High Energy Physics - Phenomenology
Abstract: New data on the Sivers azimuthal asymmetry measured in semi-inclusive deep-inelastic scattering processes have recently been released by the COMPASS Collaboration at CERN. Their increased precision and their particular binning, in terms of $Q^2$ as well as $x$, motivates a new extraction of the Sivers function, within the framework of a simple and transparent parametrization. Signals of TMD effects visible in the Sivers asymmetries are critically assessed. A thorough study of the uncertainties affecting the extracted Sivers function is presented, including the low-$x$ and large-$x$ regions., Comment: 20 pages, 13 figures
Published: 2018
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4. Science Requirements and Detector Concepts for the Electron-Ion Collider: EIC Yellow Report

Author: Abdul Khalek, R., Accardi, A., Adam, J., Adamiak, D., Akers, W., Albaladejo, M., Al-bataineh, A., Alexeev, M.G., Ameli, F., Antonioli, P., Armesto, N., Armstrong, W.R., Arratia, M., Arrington, J., Asaturyan, A., Asai, M., Aschenauer, E.C., Aune, S., Avagyan, H., Ayerbe Gayoso, C., Azmoun, B., Bacchetta, A., Baker, M.D., Barbosa, F., Barion, L., Barish, K.N., Barry, P.C., Battaglieri, M., Bazilevsky, A., Behera, N.K., Benmokhtar, F., Berdnikov, V.V., Bernauer, J.C., Bertone, V., Bhattacharya, S., Bissolotti, C., Boer, D., Boglione, M., Bondì, M., Boora, P., Borsa, I., Bossù, F., Bozzi, G., Brandenburg, J.D., Brei, N., Bressan, A., Brooks, W.K., Bufalino, S., Bukhari, M.H.S., Burkert, V., Buttimore, N.H., Camsonne, A., Celentano, A., Celiberto, F.G., Chang, W., Chatterjee, C., Chen, K., Chetry, T., Chiarusi, T., Chien, Y.-T., Chiosso, M., Chu, X., Chudakov, E., Cicala, G., Cisbani, E., Cloet, I.C., Cocuzza, C., Cole, P.L., Colella, D., Collins, J.L., II, Constantinou, M., Contalbrigo, M., Contin, G., Corliss, R., Cosyn, W., Courtoy, A., Crafts, J., Cruz-Torres, R., Cuevas, R.C., D'Alesio, U., Dalla Torre, S., Das, D., Dasgupta, S.S., Da Silva, C., Deconinck, W., Defurne, M., DeGraw, W., Dehmelt, K., Del Dotto, A., Delcarro, F., Deshpande, A., Detmold, W., De Vita, R., Diefenthaler, M., Dilks, C., Dixit, D.U., Dulat, S., Dumitru, A., Dupré, R., Durham, J.M., Echevarria, M.G., El Fassi, L., Elia, D., Ent, R., Esha, R., Ethier, J.J., Evdokimov, O., Eyser, K.O., Fanelli, C., Fatemi, R., Fazio, S., Fernandez-Ramirez, C., Finger, M., Finger, M., Jr., Fitzgerald, D., Flore, C., Frederico, T., Friščić, I., Fucini, S., Furletov, S., Furletova, Y., Gal, C., Gamberg, L., Gao, H., Garg, P., Gaskell, D., Gates, K., Gay Ducati, M.B., Gericke, M., Gil Da Silveira, G., Girod, F.-X., Glazier, D.I., Gnanvo, K., Goncalves, V.P., Gonella, L., Gonzalez Hernandez, J.O., Goto, Y., Grancagnolo, F., Greiner, L.C., Guryn, W., Guzey, V., Hatta, Y., Hattawy, M., Hauenstein, F., He, X., Hemmick, T.K., Hen, O., Heyes, G., Higinbotham, D.W., Hiller Blin, A.N., Hobbs, T.J., Hohlmann, M., Horn, T., Hou, T.-J., Huang, J., Huang, Q., Huber, G.M., Hyde, C.E., Iakovidis, G., Ilieva, Y., Jacak, B.V., Jacobs, P.M., Jadhav, M., Janoska, Z., Jentsch, A., Jezo, T., Jing, X., Jones, P.G., Joo, K., Joosten, S., Kafka, V., Kalantarians, N., Kalicy, G., Kang, D., Kang, Z.B., Kauder, K., Kay, S.J.D., Keppel, C.E., Kim, J., Kiselev, A., Klasen, M., Klein, S., Klest, H.T., Korchak, O., Kostina, A., Kotko, P., Kovchegov, Y.V., Krelina, M., Kuleshov, S., Kumano, S., Kumar, K.S., Kumar, R., Kumar, L., Kumerički, K., Kusina, A., Kutak, K., Lai, Y.S., Lalwani, K., Lappi, T., Lauret, J., Lavinsky, M., Lawrence, D., Lednicky, D., Lee, C., Lee, K., Lee, S.H., Levorato, S., Li, H., Li, S., Li, W., Li, X., Li, W.B., Ligonzo, T., Liu, H., Liu, M.X., Liu, X., Liuti, S., Liyanage, N., Lorcé, C., Lu, Z., Lucero, G., Lukow, N.S., Lunghi, E., Majka, R., Makris, Y., Mandjavidze, I., Mantry, S., Mäntysaari, H., Marhauser, F., Markowitz, P., Marsicano, L., Mastroserio, A., Mathieu, V., Mehtar-Tani, Y., Melnitchouk, W., Mendez, L., Metz, A., Meziani, Z.-E., Mezrag, C., Mihovilovič, M., Milner, R., Mirazita, M., Mkrtchyan, H., Mkrtchyan, A., Mochalov, V., Moiseev, V., Mondal, M.M., Morreale, A., Morrison, D., Motyka, L., Moutarde, H., Muñoz Camacho, C., Murgia, F., Murray, M.J., Musico, P., Nadel-Turonski, P., Nadolsky, P.M., Nam, J., Newman, P.R., Neyret, D., Nguyen, D., Nocera, E.R., Noferini, F., Noto, F., Nunes, A.S., Okorokov, V.A., Olness, F., Osborn, J.D., Page, B.S., Park, S., Parker, A., Paschke, K., Pasquini, B., Paukkunen, H., Paul, S., Pecar, C., Pegg, I.L., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Petriello, F., Petti, R., Pilloni, A., Pinkenburg, C., Pire, B., Pisano, C., Pitonyak, D., Poblaguev, A.A., Polakovic, T., Posik, M., Potekhin, M., Preghenella, R., Preins, S., Prokudin, A., Pujahari, P., Purschke, M.L., Pybus, J.R., Radici, M., Rajput-Ghoshal, R., Reimer, P.E., Rinaldi, M., Ringer, F., Roberts, C.D., Rodini, S., Rojo, J., Romanov, D., Rossi, P., Santopinto, E., Sarsour, M., Sassot, R., Sato, N., Schenke, B., Schmidke, W.B., Schmidt, I., Schmidt, A., Schmookler, B., Schnell, G., Schweitzer, P., Schwiening, J., Scimemi, I., Scopetta, S., Segovia, J., Seidl, R., Sekula, S., Semenov-Tian-Shanskiy, K., Shao, D.Y., Sherrill, N., Sichtermann, E., Siddikov, M., Signori, A., Singh, B.K., Širca, S., Slifer, K., Slominski, W., Sokhan, D., Sondheim, W.E., Song, Y., Soto, O., Spiesberger, H., Stasto, A.M., Stepanov, P., Sterman, G., Stevens, J.R., Stewart, I.W., Strakovsky, I., Strikman, M., Sturm, M., Stutzman, M.L., Sullivan, M., Surrow, B., Svihra, P., Syritsyn, S., Szczepaniak, A., Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A.S., Tapia Takaki, J.D., Tassielli, G.F., Terry, J., Tessarotto, F., Tezgin, K., Tomasek, L., Torales Acosta, F., Tribedy, P., Tricoli, A., Triloki, Tripathi, S., Trotta, R.L., Tsai, O.D., Tu, Z., Tuvè, C., Ullrich, T., Ungaro, M., Urciuoli, G.M., Valentini, A., Vancura, P., Vandenbroucke, M., Van Hulse, C., Varner, G., Venugopalan, R., Vitev, I., Vladimirov, A., Volpe, G., Vossen, A., Voutier, E., Wagner, J., Wallon, S., Wang, H., Wang, Q., Wang, X., Wei, S.Y., Weiss, C., Wenaus, T., Wennlöf, H., Wickramaarachchi, N., Wikramanayake, A., Winney, D., Wong, C.P., Woody, C., Xia, L., Xiao, B.W., Xie, J., Xing, H., Xu, Q.H., Zhang, J., Zhang, S., Zhang, Z., Zhao, Z.W., Zhao, Y.X., Zheng, L., Zhou, Y., and Zurita, P.
Published: 2022
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5. Simultaneous reweighting of Transverse Momentum Dependent distributions

Author: Boglione, M., primary, D'Alesio, U., additional, Flore, C., additional, Gonzalez-Hernandez, J.O., additional, Murgia, F., additional, and Prokudin, A., additional
Published: 2024
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6. Identifying the most influential parameters in experimental grass fire spread modeling using global sensitivity analysis

Author: Roubelat, Flore C., primary, Costes, Aurélien, additional, Antolin, William P., additional, and Rochoux, Mélanie C., additional
Published: 2022
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7. Bisphenol S instead of Bisphenol A: Toxicokinetic investigations in the ovine materno-feto-placental unit

Author: Flore C. Grandin, Marlène Z. Lacroix, Véronique Gayrard, Glenn Gauderat, Hanna Mila, Pierre-Louis Toutain, and Nicole Picard-Hagen
Subjects: Environmental sciences, GE1-350
Abstract: Bisphenol S (BPS) is widely used as a substitute for Bisphenol A in consumer products. Despite its potential endocrine-disrupting effects and widespread exposure, toxicokinetic data, particularly during the critical period of pregnancy, are not available for BPS. The objectives of our study were to evaluate the mechanisms determining fetal exposure to BPS and to BPS glucuronide (BPSG) and to compare them with those prevailing for BPA.The disposition of BPS and BPSG was evaluated in the materno-fetal unit of the catheterized pregnant ewe model, following intravenous administrations of BPS and BPSG to mothers and their fetuses. In a second experiment, the rate of BPS accumulation in the fetal compartment was determined under steady-state conditions after repeated intravenous BPS administrations to the mother.In the maternal compartment, BPS was mainly metabolized into BPSG and totally eliminated in urine. Only 0.40% of the maternal dose was transferred to the fetus. However, once in the fetal compartment, 26% of the fetal dose was rapidly eliminated through placental transfer, while 46% of BPS was metabolized into BPSG which remained trapped in the fetal compartment. Thus, the elimination of BPSG from the fetal compartment required its back-conversion into bioactive BPS, leading to an 87% enhancement of the fetal BPS exposure.Our findings demonstrate that, despite the low materno-fetal placental transfer of BPS, this substitute for BPA is able to accumulate in the fetal compartment after repeated maternal exposure, leading to chronic fetal exposure to BPS in a range of concentrations similar to those of BPA. Keywords: Bisphenol S, Bisphenol S Glucuronide, Toxicokinetic, Fetal exposure, Bisphenol A analogue
Published: 2018
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8. Effects of Malaria and HIV Infection on Anemia and T-cells Levels in Children in Douala City, Cameroon

Author: Charlie Ngo Bayoï, Léopold G Lehman, Calvin Tonga, Lafortune Kangam, Godlove B Wepnje, Flore C Tchanga, and Minette E Tomedi
Subjects: General Engineering
Abstract: Introduction Human immunodeficiency virus (HIV) infection and malaria are priority health issues for sub-Saharan Africa. Both diseases worsen each other through their effect on the immune and hematological systems. This study aimed to determine the effects of HIV infection and asymptomatic malaria on anemia and T-cells counts in children in the city of Douala in the republic of Cameroon. Method From May to November 2016, 197 HIV infected and 98 HIV-free non-febrile children up to 19 years old (128 male and 167 female) participated in the study. All HIV-infected children were receiving antiretroviral treatment and co-trimoxazole. Malaria diagnosis was performed using Giemsa-stained thick blood film; immunological and hematological parameters were assessed through a flow cytometer and an automated analyzer respectively. Chi-squared or Fischer's exact tests was used to compare the proportions, Mann-Whitney and ANOVA tests were used for the means. Statistical significance was set at p˂0.05. Results The prevalence of malaria was 8.8%, and that of anemia was 40.7%. CD4
Published: 2022

9. Effects of Malaria and HIV Infection on Anemia and T-cells Levels in Children in Douala City, Cameroon

Author: Ngo Bayoï, Charlie, primary, Lehman, Léopold G, additional, Tonga, Calvin, additional, Kangam, Lafortune, additional, Wepnje, Godlove B, additional, Tchanga, Flore C, additional, and Tomedi, Minette E, additional
Published: 2022
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10. PO-1887 Validation of deep learning auto-segmentation in pelvic organs at risk: a preliminary analysis

Author: Piro, D., primary, Marras, M., additional, D'Aviero, A., additional, Boschetti, A., additional, Votta, C., additional, Re, A., additional, Catucci, F., additional, Cusumano, D., additional, Di Dio, C., additional, Menna, S., additional, Iezzi, M., additional, Quaranta, F., additional, Flore, C., additional, Sanna, E., additional, Piccari, D., additional, Mattiucci, G.C., additional, and Valentini, V., additional
Published: 2022
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11. PO-1481 Radiological measurements to predict dose variation due to inter-fraction variability in H&N

Author: Catucci, F., primary, Cusumano, D., additional, Menna, S., additional, D'Aviero, A., additional, Di Dio, C., additional, Re, A., additional, Iezzi, M., additional, Piccari, D., additional, Quaranta, F., additional, Boschetti, A., additional, Marras, M., additional, Piro, D., additional, Votta, C., additional, Sanna, E., additional, Flore, C., additional, Mattiucci, G.C., additional, and Valentini, V., additional
Published: 2022
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12. PO-1483 A predictive model to quantify the dosimetric impact of inter-fraction variability in breast cancer

Author: Iezzi, M., primary, Cusumano, D., additional, Piccari, D., additional, Menna, S., additional, Catucci, F., additional, D'Aviero, A., additional, Re, A., additional, Di Dio, C., additional, Quaranta, F., additional, Boschetti, A., additional, Marras, M., additional, Piro, D., additional, Votta, C., additional, Sanna, E., additional, Flore, C., additional, Mattiucci, G.C., additional, and Valentini, V., additional
Published: 2022
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13. PD-0336 Evaluation of a deep-learning segmentation software in thoracic organs at risk: an early analysis

Author: Boschetti, A., primary, Votta, C., additional, Re, A., additional, Piro, D., additional, Marras, M., additional, D'Aviero, A., additional, Catucci, F., additional, Cusumano, D., additional, Di Dio, C., additional, Menna, S., additional, Iezzi, M., additional, Quaranta, F.V., additional, Flore, C., additional, Sanna, E.G., additional, Piccari, D., additional, Mattiucci, G.C., additional, and Valentini, V., additional
Published: 2022
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14. Identifying the most influential parameters in experimental grass fire spread modeling using global sensitivity analysis

Author: Flore C. Roubelat, Aurélien Costes, William P. Antolin, and Mélanie C. Rochoux
Abstract: Coupled atmosphere/fire models are recognized as an efficient and representative way to simulate wildland fire behavior at geographical-to-meteorological scales by representing the two-way interactions between the fire front propagation and the surrounding atmosphere. They rely on a rate-of-spread (ROS) parameterization to represent the fire front propagation speed with respect to environmental factors characterizing biomass fuel properties and moisture content, near-surface wind conditions and terrain slope. In actual wildfire events, these input parameters are only partially known and induce significant uncertainties in the coupled model predictions. To estimate the envelope of plausible wildland fire behavior for a given event, we aim at designing a perturbed-physics ensemble prediction capability based on a coupled atmosphere/fire model. To make the approach feasible, it is essential to identify the relevant subset of parameters to perturb to generate an ensemble of fire front positions and shapes. In the present study, we perform a global sensitivity analysis based on Sobolâ€™ indices to rank the environmental factors by order of influence on the Balbiâ€™s ROS parameterization, and thereby identify the parameters that contribute most to the variability of ROS. Results show the predominance of the near-surface wind speed on the ROS variability, followed by the leaf area index LAI, the ignition temperature T_i, the dead fuel moisture content M_d, the dead fuel particle mass density ho_d, and the fuel layer height e. Results also indicate that the sensitivity of each fuel parameter to the ROS is not constant with respect to the near-surface wind speed, and that the most influential input parameters differ between the head and the back of a fire. This indicates the importance of exploring the spatial and temporal dependencies of coupled model sensitivities in future work.
Published: 2022

15. Les liposomes : description, fabrication et applications

Author: Brasseur R., Thomas A., Flore C., and Lorin A.
Subjects: Bilayer, phospholipid, motion, application, fusion, preparation, Biotechnology, TP248.13-248.65, Environmental sciences, GE1-350
Abstract: Liposomes: description, preparation and applications. Liposomes are spherical vesicles with a diameter ranging from 20 nm to a few thousands nm. These vesicles consist of one or several bilayers which separate an intravesicular from an external medium. Within these bilayers, like in the biological membrane, motion of phospholipids is observed. Liposomes are easy to prepare. The hydration of a phospholipidic film leads to the formation of multilamellar liposomes. Additional steps are required to form unilamellar liposomes. Liposomes are used for industrial purposes, such as the targeting of cosmetological compounds. They may also be used as therapy vectors, for drug delivery or as vaccine supports. Liposomes are good models for membranes and are widely used for improving the understanding of biological events that occur in cell membranes, such as permeability, fluidity, protein anchoring and fusion of membranes. This paper mainly emphasizes membrane fusion.
Published: 2004

16. Reweighting the Sivers function with jet data from STAR

Author: Boglione, M., D'Alesio, U., Flore, C., Gonzalez-Hernandez, J.O., Murgia, F., and Prokudin, A.
Published: 2021
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17. Quantitative method for conjugated metabolites of bisphenol A and bisphenol S determination in food of animal origin by Ultra High Performance Liquid Chromatography–Tandem Mass Spectrometry

Author: Catherine Viguié, Bruno Veyrand, Emmanuelle Bichon, Yoann Deceuninck, B. Le Bizec, Philippe Marchand, T. Gény, Flore C. Grandin, Laboratoire d'étude des Résidus et Contaminants dans les Aliments (LABERCA), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3)
Subjects: endocrine system, Bisphenol A, Bisphenol S, [SDV]Life Sciences [q-bio], UHPLC–MS/MS, Food Contamination, Sulfuric Acid Esters, Isotope dilution, 010402 general chemistry, 01 natural sciences, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, Glucuronides, Phenols, Limit of Detection, Pregnancy, Tandem Mass Spectrometry, Liquid chromatography–mass spectrometry, Animals, Sulfones, Solid phase extraction, Benzhydryl Compounds, Chromatography, High Pressure Liquid, Detection limit, Foodstuffs, Sheep, Chromatography, urogenital system, Solid Phase Extraction, 010401 analytical chemistry, Organic Chemistry, Extraction (chemistry), General Medicine, Contamination, 0104 chemical sciences, chemistry, Female, hormones, hormone substitutes, and hormone antagonists, Conjugated metabolites, Food Analysis
Abstract: International audience; With the objectives of both generating bisphenols (BPs) conjugates occurrence data in food from animal origin but also investigating the origin of associated contamination, the present study deals with the development of an efficient analytical method aiming at monitoring both BPA and BPS conjugated metabolites in food from animal origin. The objective of such monitoring is to determine the origin of BPs contamination (FCM or animal contamination). The targeted compounds were BPA-monoglucuronide (BPA-1G), BPA-diglucuronide (BPA-2G), BPA-monosulfate (BPA-1S), BPA-disulfate (BPA-2S) and BPS-monoglucuronide (BPS-1G). The developed standard operating procedure includes a preliminary solid-liquid extraction step followed by two successive solid phase extraction (SPE) stages, using successively a non-polar phase and a strong cation exchange polymer. Quantification was achieved according to both the isotopic dilution and surrogated quantification methods, using 13C-BPA-1G and BPA-d6-1S as internal standards. Linearity was validated (R2 > 0.99) for each molecule within the concentration range [0-10] μg kg-1. Detection limits ranged from 0.02 μg kg-1 (BPA-1G in muscle, BPA-1S and BPA-2G in liver) to 0.50 μg kg-1 (BPA-2S in muscle). The strategy was then proven on liver samples collected from pregnant ewes subcutaneously exposed to BPA during 105 days, at 50 μg kg-1 per day. BPA-1G, BPA-2G and BPA-1S were detected and quantified at a concentration of 3.81 μg kg-1, 0.80 μg kg-1 and 0.09 μg kg-1, respectively. The analytical method was finally implemented on fifty unpacked food samples from animal origin in which significant free BPA concentrations were previously measured. Since no metabolites of BPA could be measured (
Published: 2019

18. Blood Lead Levels in Children of S.W. Sardinia

Author: Cardia, P., Pau, M., Ibba, A., Flore, C., Cherchi, P., and Casula, D.
Published: 1989

19. Basal Ti level in the human placenta and meconium and evidence of a materno- foetal transfer of food-grade TiO2 nanoparticles in an ex vivo placental perfusion model

Author: Adèle Guillard, Eric Gaultier, Christel Cartier, Laurent Devoille, Johanna Noireaux, Laurence Chevalier, Mathieu Morin, Grandin, Flore C., Mz Lacroix, Christine Coméra, Aude Cazanave, Alice de Place, Véronique Gayrard-Troy, Véronique Bach, Karen Chardon, Nihel Bekhti, Karine Adel-Patient, Vayssière, C., Fisicaro, P., Feltin, N., La Farge, F., Nicole Picard-Hagen, Bruno Lamas, Eric Houdeau, Endocrinologie & Toxicologie de la Barrière Intestinale (ToxAlim-ENTeRisk), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire National de Métrologie et d'Essais [Trappes] (LNE ), Laboratoire National de Métrologie et d’Essais (LNE), Groupe de physique des matériaux (GPM), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Innovations Thérapeutiques et Résistances (InTheRes), Ecole Nationale Vétérinaire de Toulouse (ENVT), Neuro-Gastroentérologie & Nutrition (ToxAlim-NGN), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université de Picardie Jules Verne (UPJV), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Hôpital Paule de Viguier, CHU Toulouse [Toulouse], Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de l'Environnement Industriel et des Risques, and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: human placenta, [SDV]Life Sciences [q-bio], Titanium dioxide, nanoparticles, E171 food additive, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

20. Bisphenol S instead of Bisphenol A: Toxicokinetic investigations in the ovine materno-feto-placental unit

Author: Hanna Mila, Nicole Picard-Hagen, Marlène Z. Lacroix, Pierre-Louis Toutain, Glenn Gauderat, Véronique Gayrard, Flore C. Grandin, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Innovations Thérapeutiques et Résistances (InTheRes), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3)
Subjects: 0301 basic medicine, Male, Bisphenol A, Bisphenol S, [SDV]Life Sciences [q-bio], Placenta, Urine, 010501 environmental sciences, Endocrine Disruptors, Fetal exposure, urologic and male genital diseases, 01 natural sciences, chemistry.chemical_compound, Bisphenol S Glucuronide, Pregnancy, Bisphenol A analogue, Sulfones, Maternal-Fetal Exchange, lcsh:Environmental sciences, General Environmental Science, lcsh:GE1-350, Compartment (chemistry), Toxicokinetic, 3. Good health, Toxicokinetics, embryonic structures, Female, hormones, hormone substitutes, and hormone antagonists, endocrine system, Andrology, 03 medical and health sciences, Fetus, Glucuronides, Phenols, medicine, Animals, Humans, Benzhydryl Compounds, 0105 earth and related environmental sciences, Sheep, business.industry, medicine.disease, 030104 developmental biology, chemistry, business
Abstract: Bisphenol S (BPS) is widely used as a substitute for Bisphenol A in consumer products. Despite its potential endocrine-disrupting effects and widespread exposure, toxicokinetic data, particularly during the critical period of pregnancy, are not available for BPS. The objectives of our study were to evaluate the mechanisms determining fetal exposure to BPS and to BPS glucuronide (BPSG) and to compare them with those prevailing for BPA.The disposition of BPS and BPSG was evaluated in the materno-fetal unit of the catheterized pregnant ewe model, following intravenous administrations of BPS and BPSG to mothers and their fetuses. In a second experiment, the rate of BPS accumulation in the fetal compartment was determined under steady-state conditions after repeated intravenous BPS administrations to the mother.In the maternal compartment, BPS was mainly metabolized into BPSG and totally eliminated in urine. Only 0.40% of the maternal dose was transferred to the fetus. However, once in the fetal compartment, 26% of the fetal dose was rapidly eliminated through placental transfer, while 46% of BPS was metabolized into BPSG which remained trapped in the fetal compartment. Thus, the elimination of BPSG from the fetal compartment required its back-conversion into bioactive BPS, leading to an 87% enhancement of the fetal BPS exposure.Our findings demonstrate that, despite the low materno-fetal placental transfer of BPS, this substitute for BPA is able to accumulate in the fetal compartment after repeated maternal exposure, leading to chronic fetal exposure to BPS in a range of concentrations similar to those of BPA. Keywords: Bisphenol S, Bisphenol S Glucuronide, Toxicokinetic, Fetal exposure, Bisphenol A analogue
Published: 2018

21. Toxicokinetics of bisphenol S in rats for predicting human bisphenol S clearance from allometric scaling

Author: Gayrard, Véronique, primary, Lacroix, Marlène Z., additional, Gély, Clémence A., additional, Grandin, Flore C., additional, Léandri, Roger, additional, Bouchard, Michèle, additional, Roques, Béatrice, additional, Toutain, Pierre-Louis, additional, and Picard-Hagen, Nicole, additional
Published: 2020
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22. Food-grade TiO2 (E171) nanoparticles cross the human placental barrier: an ex vivo study on isolated and perfused placentae

Author: Adèle Guillard, Eric Gaultier, Christel Cartier, Devoille, L., Noireaux, J., Chevalier, L., Oster, C., Grandin, Flore C., Christine Coméra, Aude Cazanave, Place, A., Morin, M., Vayssière, C., Gambier, S., Feltin, N., La Farge, F., Véronique Gayrard-Troy, Véronique Bach, Karen Chardon, Fisicaro, P., Nicole Picard-Hagen, Eric Houdeau, Endocrinologie & Toxicologie de la Barrière Intestinale (ToxAlim-ENTeRisk), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Laboratoire National de Métrologie et d'Essais (LNE), Centre National de la Recherche Scientifique (CNRS), Neuro-Gastroentérologie & Nutrition (ToxAlim-NGN), Hôpital Universitaire de Toulouse, Luxembourg Institute of Science and Technology (LIST), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université de Picardie Jules Verne (UPJV), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de l'Environnement Industriel et des Risques, Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT), Institut de Mathématiques de Marseille (I2M), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), and Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie
Subjects: [SDV]Life Sciences [q-bio], [SDV.TOX]Life Sciences [q-bio]/Toxicology, ComputingMilieux_MISCELLANEOUS
Abstract: 55th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions, Helsinki, FINLAND, SEP 08-11, 2019; International audience
Published: 2019

23. Developpement d'une approche intégrative pour évaluer l'exposition interne foetale humaine au bisphénol S

Author: Nicole Picard-Hagen, Grandin, Flore C., Lacroix, Marlène Z., Christophe Vayssière, Mathieu Morin, Marie-Line Morvanc, Jean‐philippe Antignac, Catherine Viguié, Bruno Le Bizec, Gayrard-Troy, Véronique V., Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Innovations Thérapeutiques et Résistances (InTheRes), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Centre hospitalier universitaire de Toulouse - CHU Toulouse, Laboratoire d'étude des Résidus et Contaminants dans les Aliments (LABERCA), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Baures, Simone
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

24. Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs

Author: Marlène Z. Lacroix, Hanna Mila, Catherine Viguié, Pierre-Louis Toutain, Clémence A. Gély, Véronique Gayrard, Séverine H. Collet, Roger Leandri, Flore C. Grandin, Michèle Bouchard, Nicole Picard-Hagen, Blandine Rabozzi, Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Innovations Thérapeutiques et Résistances (InTheRes), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université de Montréal (UdeM), CHU Toulouse [Toulouse], University of London, and French National Research Program for Environmental and Occupational Health of Agence nationale de securite sanitaire de l'alimentation, de l'environnement et du travail (ANSES) [2017/1/174]
Subjects: Male, endocrine system, Hormonal activity, Bisphenol A, Health, Toxicology and Mutagenesis, Sus scrofa, Administration, Oral, Biological Availability, 010501 environmental sciences, Pharmacology, urologic and male genital diseases, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Phenols, Animals, Medicine, Endocrine system, Toxicokinetics, Sulfones, 030212 general & internal medicine, Benzhydryl Compounds, reproductive and urinary physiology, 0105 earth and related environmental sciences, urogenital system, business.industry, Research, Public Health, Environmental and Occupational Health, [SDE.ES]Environmental Sciences/Environmental and Society, 3. Good health, Bioavailability, Bisphenol S, chemistry, Administration, Intravenous, Environmental Pollutants, Female, business, hormones, hormone substitutes, and hormone antagonists, Biological availability
Abstract: Background: Given its hormonal activity, bisphenol S (BPS) as a substitute for bisphenol A (BPA) could actually increase the risk of endocrine disruption if its toxicokinetic (TK) properties, namely its oral availability and systemic persistency, were higher than those of BPA. Objectives: The TK behavior of BPA and BPS was investigated by administering the two compounds by intravenous and oral routes in piglet, a known valid model for investigating oral TK. Methods: Experiments were conducted in piglets to evaluate the kinetics of BPA, BPS, and their glucuronoconjugated metabolites in plasma and urine after intravenous administration of BPA, BPS, and BPS glucuronide (BPSG) and gavage administration of BPA and BPS. A population semiphysiologically based TK model describing the disposition of BPA and BPS and their glucuronides was built from these data to estimate the key TK parameters that drive the internal exposure to active compounds. Results: The data indicated that almost all the BPS oral dose was absorbed and transported into the liver where only 41% of BPS was glucuronidated, leading to a systemic bioavailability of 57.4%. In contrast, only 77% of the oral dose of BPA was absorbed and underwent an extensive first-pass glucuronidation either in the gut (44%) or in the liver (53%), thus accounting for the low systemic bioavailability of BPA (0.50%). Due to the higher systemic availability of BPS, in comparison with BPA, and its lower plasma clearance (3.5 times lower), the oral BPS systemic exposure was on average about 250 times higher than for BPA for an equal oral molar dose of the two compounds. Conclusion: Given the similar digestive tracts of pigs and humans, our results suggest that replacing BPA with BPS will likely lead to increased internal exposure to an endocrine-active compound that would be of concern for human health. https://doi.org/10.1289/EHP4599
Published: 2019

25. Comment on 'Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model'

Author: Véronique Gayrard, Nicole Picard-Hagen, Flore C. Grandin, Pierre-Louis Toutain, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Royal Veterinary College [London], and University of London [London]
Subjects: Bisphenol A, medicine.medical_specialty, Environmental Engineering, 040301 veterinary sciences, Bisphenol F, Health, Toxicology and Mutagenesis, [SDV]Life Sciences [q-bio], 010501 environmental sciences, 01 natural sciences, 0403 veterinary science, chemistry.chemical_compound, Phenols, Pregnancy, Internal medicine, medicine, Environmental Chemistry, Toxicokinetics, Animals, Sulfones, Benzhydryl Compounds, 0105 earth and related environmental sciences, Sheep, Public Health, Environmental and Occupational Health, 04 agricultural and veterinary sciences, General Medicine, General Chemistry, medicine.disease, Pollution, Endocrinology, chemistry, Bisphenol S, Female
Abstract: Refers to: Jeremy Gingrich, Yong Pu, Richard Ehrhardt, Rajendiran Karthikraj, Kurunthachalam Kannan, Almudena Veiga-Lopez Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model Chemosphere, Volume 220, April 2019, Pages 185-194; International audience; Gingrich et al. (2019) report a comparative toxicokinetic (TK) study of Bisphenol A (BPA), Bisphenol S (BPS) and Bisphenol F (BPF) in the pregnant ewe model after a single subcutaneous administration of BPS or a mixture of BPA, BPS and BPF. The topic is highly relevant. Unfortunately, many errors were noted in the calculation of TK parameters. In the results reported, the disposition of aglycone is systematically confused with that of the corresponding glucuronide, and the interpretation of computed or observed data is therefore erroneous. This makes the paper misleading in a field that does not need these kinds of error to fuel debates that are already heated and confusing. Inspection of Table 2 immediately indicates that the computed clearances (CL) of 45.4 mL/h for BPA (but actually BPA plus BPAG) or the clearance of 5.2 mL/h for BPS (but actually BPS and BPSG) are impossible from a biological point of view. Indeed, this is clearly illustrated by the estimation of Volume of Distribution (Vss) from the product of Mean Residence Time (MRT) and Clearance (CL) (Toutain and Bousquet-Melou, 2004). The computed MRTs of 8.3 h for BPA and 6.7 h for BPS produce an estimated Vss of 4.94 and 0.457 mL/kg for BPA and BPS, respectively. However, these values are not plausible, given that the minimal possible Vss for any substance is the plasma volume (i.e. about 40 mL/kg in sheep). This error in the computation of plasma clearance is rooted in the flawed computation of the corresponding AUC (0.81 and 7.5 mg*h/mL for BPA and BPS, respectively). The order of magnitude of these AUCs can be readily obtained by dividing the maximal observed plasma concentration (Cmax of 66.7 and 643 ng/mL for BPA and BPS, respectively) by the slope of the terminal phase (that is equal to 0.693/half-life) (Toutain and Bousquet-Mélou, 2004). This leads to computed AUCs of 0.000510 and 0.00343 mg*h/mL for BPA and BPS, respectively. These roughly estimated AUCs are 1588–2185 fold lower than those reported in the present article and we suspect that the authors, at the very least, made an error in handling their concentration units. Using correctly computed AUCs would lead to estimates of total BPA and BPS plasma clearance (actually CL/F, with F the bioavailability factor associated with the subcutaneous administration) of about 980 and 146 mL/kg/h. These values would be of the same order of magnitude as the plasma clearance that we directly measured using an IV administration of BPAG and BPSG in sheep (333 and 49 mL/kg/h) for BPAG and BPSG (Gauderat et al., 2016, Grandin et al., 2018). The remaining difference is probably due in part to incomplete bioavailability following the subcutaneous administration of BPA and BPS. Moreover, the authors wrote in their “Toxicokinetic analysis” section that the TK parameters were calculated using the plasma concentrations of total BPA, BPS, or BPF (i.e. unconjugated and conjugated forms of bisphenols). Bisphenol metabolites and bisphenol aglycone are distinct substances with their own physico-chemical properties and their own dispositions. Therefore, total bisphenol concentrations cannot be considered for a meaningful TK analysis. Given that the ratio of the bisphenol metabolite over bisphenol aglycone is about 100 for BPA (Gauderat et al., 2016) and 10 for BPS (Grandin et al., 2018), the results published by Gingrich et al. describe the disposition of the bisphenol metabolites i.e. BPAG and BPSG rather than the disposition of bisphenol aglycone, at least for BPA and BPS. Hence the main message conveyed by the present paper is not related to BPA and BPS but to their mainly inactive metabolite. Other surprising results are the urinary concentrations. It is claimed that 9 h after bisphenol administration, the peak maternal urine concentrations for BPA and BPS were 1300 and 3870 ng/mL, respectively. Again, this is very unlikely as the daily urine output in sheep is similar to that of humans (i.e. 1.5 L for sheep of 76.3 Kg BW). If, as a worst-case scenario, we consider that these so-called maximal urine concentrations are similar to the average urine concentration, the total amounts of BPA/BPAG and BPS/BPSG that are eliminated by urine over 24 h are no more than 2 and 6 mg in total, i.e. about 5 and 16% of the administered dose of 36.7 mg, for BPA/BPAG and BPS/BPSG, respectively. This is at variance with the literature reports that most of the BPA/BPAG is eliminated in urine over 24 h (Gauderat et al., 2016). The discrepancy of the authors’ result may be due to the low bioavailability of the two tested compounds or, more likely, to the fact that most of the dose had already been eliminated during the first hours following subcutaneous administration and was simply missed by the sampling design because the first urine sampling at 9 h post-administration was too late. The interpretation of the results is also questionable. For instance, the authors suggest that a first-pass effect may reduce the terminal half-life of a substance or compare MRTs (as computed for an extravascular route with a mixture of the aglycone and its conjugate) with a half-life, as obtained after an IV administration. The authors may not have realized that MRT are additives, not half-lives, and that what they actually measured were not the genuine MRTs of the different substances under investigation (only possible by an IV administration) but an overall MRT that includes a Mean Absorption time (MAT) plus a Mean Time of conjugation of bisphenol aglycone into the bisphenol metabolite. This misunderstanding makes any comparison with the results obtained for Bisphenols by IV route meaningless. Finally, the authors indicate in their conclusion that “this is the first report on the toxicokinetic of either BPS and BPF in a pregnancy model”. This statement is, to our knowledge, correct for BPF but, for BPS, the first toxicokinetic parameters were published in Environment International and have been available since August 2018 (Grandin et al., 2018).
Published: 2019

26. Lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III

Author: Lins, L., Flore, C., Chapelle, L., Talmud, P.J., Thomas, A., and Brasseur, R.
Published: 2002

27. Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs

Author: Gayrard, Veronique, Lacroix, Marlene Z., Grandin, Flore C., Collet, Severine H., Mila, Hanna, Viguie, Catherine, Gely, Clemence A., Rabozzi, Blandine, Bouchard, Michele, Leandri, Roger, Toutain, Pierre-Louis, and Picard-Hagen, Nicole
Subjects: Phenols -- Health aspects, Pharmacology, Experimental, Bioavailability -- Research, Endocrine gland diseases -- Models -- Risk factors -- Development and progression, Environmental issues, Health
Abstract: Background: Given its hormonal activity, bisphenol S (BPS) as a substitute for bisphenol A (BPA) could actually increase the risk of endocrine disruption if its toxicokinetic (TK) properties, namely its oral availability and systemic persistency, were higher than those of BPA. Objectives: The TK behavior of BPA and BPS was investigated by administering the two compounds by intravenous and oral routes in piglet, a known valid model for investigating oral TK. Methods: Experiments were conducted in piglets to evaluate the kinetics of BPA, BPS, and their glucuronoconjugated metabolites in plasma and urine after intravenous administration of BPA, BPS, and BPS glucuronide (BPSG) and gavage administration of BPA and BPS. A population semiphysiologically based TK model describing the disposition of BPA and BPS and their glucuronides was built from these data to estimate the key TK parameters that drive the internal exposure to active compounds. Results: The data indicated that almost all the BPS oral dose was absorbed and transported into the liver where only 41% of BPS was glucuronidated, leading to a systemic bioavailability of 57.4%. In contrast, only 77% of the oral dose of BPA was absorbed and underwent an extensive firstpass glucuronidation either in the gut (44%) or in the liver (53%), thus accounting for the low systemic bioavailability of BPA (0.50%). Due to the higher systemic availability of BPS, in comparison with BPA, and its lower plasma clearance (3.5 times lower), the oral BPS systemic exposure was on average about 250 times higher than for BPA for an equal oral molar dose of the two compounds. Conclusion: Given the similar digestive tracts of pigs and humans, our results suggest that replacing BPA with BPS will likely lead to increased internal exposure to an endocrine-active compound that would be of concern for human health. https://doi.org/10.1289/EHP4599, Introduction Due to concerns about its safety, the use of bisphenol A (BPA) has been restricted, and structural analogs, especially bisphenol S (BPS), have mainly replaced BPA in consumer products [...]
Published: 2019
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28. Toxicokinetics of bisphenol S in rats for predicting human bisphenol S clearance from allometric scaling

Author: Flore C. Grandin, Nicole Picard-Hagen, Michèle Bouchard, Véronique Gayrard, Clémence A. Gély, Marlène Z. Lacroix, Pierre-Louis Toutain, Roger Leandri, Béatrice B. Roques, Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Innovations Thérapeutiques et Résistances (InTheRes), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, CHU Toulouse [Toulouse], Université de Montréal (UdeM), and University of London
Subjects: endocrine system, medicine.medical_specialty, Bisphenol A, Metabolic Clearance Rate, Swine, clearance, [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain, 010501 environmental sciences, urologic and male genital diseases, Toxicology, Body weight, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, bisphenol S, Phenols, Internal medicine, toxicokinetics, medicine, Animals, Humans, Toxicokinetics, Sulfones, Rats, Wistar, 030304 developmental biology, 0105 earth and related environmental sciences, Pharmacology, 0303 health sciences, Plasma clearance, Sheep, Chemistry, Rats, Endocrinology, Bisphenol S, Female, Allometry, allometric scaling, hormones, hormone substitutes, and hormone antagonists
Abstract: International audience; Previous data obtained in piglets suggested that despite structural analogy with Bisphenol A (BPA), Bisphenol S (BPS) elimination may proceed more slowly, resulting in a much higher systemic exposure to unconjugated BPS than to BPA. Interspecies allometric scaling was applied to predict the toxicokinetic (TK) parameters of BPS, namely plasma clearance in humans from values obtained in animals, and thus contribute to assessment of the human internal exposure to BPS. Allometric scaling was performed using mean BPS plasma clearance values measured in rats after intravenous administration of 5 mg BPS /kg body weight (BW) and those previously obtained in piglets and sheep using identical IV BPS dosing and analytical procedures. The BPS plasma clearance, evaluated at 0.92 L/kg.h in rats, was proportional to species body weight, enabling the prediction of human BPS plasma clearance by extrapolating to a BW of 70 kg. The estimated BPS plasma clearance in humans was thus 0.92 L/min (0.79 L/kg.h), i.e. about two times lower than the previously estimated BPA clearance (1.79 L/min). By increasing systemic exposure to the active moiety of an environmental estrogenic chemical, this less efficient clearance of BPS in humans, as compared with BPA, might worsen the harmful consequences of replacing BPA by BPS.
Published: 2020

29. Development of an experimental approach to evaluate the human fetal internal exposure to Bisphenol S

Author: Grandin, Flore C., ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Institut National Polytechnique (Toulouse), Nicole Picard-Hagen et Marlène Lacroix, and ProdInra, Migration
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], Bisphénol S, exposition fœtale, perturbateur endocrinien, toxicocinétique, passage placentaire, substitut du Bisphénol A, stéroïdogenèse, these
Abstract: Le bisphénol S (BPS) est largement utilisé comme substitut du Bisphénol A (BPA) et l’exposition humaine au BPS est désormais ubiquitaire. Or, le BPS, à l’instar du BPA, présente un potentiel perturbateur endocrinien, ce qui soulève la question du risque liée à une exposition fœtale au BPS pour la santé humaine. Dans ce contexte, l’objectif de cette thèse est d’évaluer l’exposition fœtale au BPS et de caractériser des biomarqueurs phénotypiques d’exposition fœtale et/ou d’effet du BPS à partir d’une signature stéroïdomique. Une étude toxicocinétique réalisée sur le modèle du fœtus ovin a montré que le transfert materno-fœtal du BPS est faible. Cependant, le BPS et son principal métabolite, le BPS glucuronide, sont lentement éliminés du compartiment fœtal en raison d’un passage placentaire fœto-maternel du BPS limité et de la faible vitesse de réactivation du BPSG en BPS. Il en résulte une exposition fœtale au BPS similaire à celle au BPA, lors d’exposition maternelle répétée. L’étude du transfert placentaire du BPS et du BPSG sur le modèle de placenta humain perfusé a conforté les résultats observés chez le mouton, avec des faibles transferts materno-fœtal et fœto maternel du BPS, respectivement 10 et 3 fois inférieurs à ceux du BPA. L’exposition maternelle quotidienne au BPS au cours de la gestation chez la brebis n’a pas eu d’impact sur les voies de biosynthèse des androgènes dans l’unité materno-fœto-placentaire pour les fœtus mâles. Bien que le potentiel d’exposition fœtale du BPS est similaire à celui du BPA, nous n’avons pas mis en évidence d’effets associés à cette exposition
Published: 2018

30. Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta

Author: Nicole Picard-Hagen, Mathieu Morin, Hanna Mila, Catherine Viguié, Clémence A. Gély, Cécile Gayrard, Pierre-Louis Toutain, Marlène Z. Lacroix, Julie Corbett, Alice de Place, Véronique Gayrard, Flore C. Grandin, Christophe Vayssière, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Innovations Thérapeutiques et Résistances (InTheRes), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, CHU Toulouse [Toulouse], Université Fédérale Toulouse Midi-Pyrénées, Royal Veterinary College [London], and University of London [London]
Subjects: medicine.medical_specialty, Bisphenol A, Environmental Engineering, Bisphenol S, Health, Toxicology and Mutagenesis, Metabolite, [SDV]Life Sciences [q-bio], Placenta, 0208 environmental biotechnology, 02 engineering and technology, 010501 environmental sciences, urologic and male genital diseases, 01 natural sciences, chemistry.chemical_compound, Fetus, Glucuronides, Phenols, Pregnancy, Internal medicine, medicine, Environmental Chemistry, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Sulfones, Bisphenol S glucuronide, Benzhydryl Compounds, Maternal-Fetal Exchange, 0105 earth and related environmental sciences, Chemistry, Human placental transport, Public Health, Environmental and Occupational Health, Albumin, General Medicine, General Chemistry, Pollution, 020801 environmental engineering, Endocrinology, medicine.anatomical_structure, Endocrine disruptor, embryonic structures, Female, Glucuronide, hormones, hormone substitutes, and hormone antagonists
Abstract: International audience; The aim of our study was to evaluate the bidirectional transfer of Bisphenol S (BPS) and its main metabolite, BPS Glucuronide (BPSG), using the model of perfused human placenta and to compare the obtained values with those of Bisphenol A (BPA) and BPA Glucuronide. Fourteen placentas at term were perfused in an open dual circuit with deuterated BPS (1 and 5 μM) and non-labelled BPSG (2.5 μM) and a freely diffusing marker antipyrine (800 ng/ml) in the presence of albumin (25 mg/ml). In a second experiment, the potential role of P-glycoprotein in the active efflux of BPS across the placental barrier was studied using the well-established P-glycoprotein inhibitor, PSC833 (2 and 4 μM). Placental transfer of BPS was much lower than that of BPA in both directions. The placental clearance index of BPS in the materno-fetal direction was three times lower than in the opposite direction, strongly suggesting some active efflux transport. However, our results show that P-glycoprotein is not involved in limiting the materno-fetal transfer of BPS. Placental transfer of BPSG in the fetal compartment was almost non-existent indicating that, in the fetal compartment, BPSG originates mainly from feto-placental metabolism. The feto-maternal clearance index for BPSG was 20-fold higher than the materno-fetal index. We conclude that the blood-placental barrier is much more efficient in limiting fetal exposure to BPS than to BPA, indicating that the placenta has a crucial role in protecting the human fetus from BPS exposure.
Published: 2018

31. Comment on 'Pharmacokinetics of bisphenol S in humans after a single oral administration'

Author: Nicole Picard-Hagen, Pierre-Louis Toutain, Véronique Gayrard, Marlène Z. Lacroix, Flore C. Grandin, Hanna Mila, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Innovations Thérapeutiques et Résistances (InTheRes), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Royal Veterinary College - University of London
Subjects: 010504 meteorology & atmospheric sciences, business.industry, [SDV]Life Sciences [q-bio], Administration, Oral, 010501 environmental sciences, Pharmacology, 01 natural sciences, 3. Good health, chemistry.chemical_compound, Pharmacokinetics, chemistry, Bisphenol S, Phenols, Oral administration, Medicine, Humans, Benzhydryl compounds, Sulfones, Benzhydryl Compounds, business, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, General Environmental Science
Abstract: International audience
Published: 2018

32. Bisphenol S, used as bisphenol A alternative, accumulates in the fetal compartment throughout gestation

Author: Grandin, Flore C., Lacroix, Marlène Z., Gayrard-Troy, Véronique V., Catherine Viguié, Hanna Mila, Pierre-Louis Toutain, Nicole Picard-Hagen, ProdInra, Migration, ToxAlim (ToxAlim), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Innovations Thérapeutiques et Résistances (InTheRes), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), University of London, and French National Research Program for Environmental and Occupational Health of Anses [2015/11/12]
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

33. Comment on “Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model”

Author: Grandin, Flore C., primary, Gayrard, Véronique, additional, Picard-Hagen, Nicole, additional, and Toutain, Pierre-Louis, additional
Published: 2019
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34. Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta

Author: Grandin, Flore C., primary, Lacroix, Marlène Z., additional, Gayrard, Véronique, additional, Viguié, Catherine, additional, Mila, Hanna, additional, de Place, Alice, additional, Vayssière, Christophe, additional, Morin, Mathieu, additional, Corbett, Julie, additional, Gayrard, Cécile, additional, Gely, Clémence A., additional, Toutain, Pierre-Louis, additional, and Picard-Hagen, Nicole, additional
Published: 2019
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35. Value of histochemical stains for copper in the diagnosis of Wilson's disease

Author: Pilloni, L, Lecca, S, Van Eyken, P, Flore, C, Demelia, L, Pilleri, G, Nurchi, A M, Farci, A M G, Ambu, R, Callea, F, and Faa, G
Published: 1998

36. Proceedings, 8th Young Researchers Meeting (YRM 2017)

Author: Agostini, F, Antolini, C, Cacciotto, P, Cadeddu, M, Casula, E, Cattani, G, Cultrera, A, Di Stefano, M, Flore, C, Franzin, E, Giovannelli, L, Incani, E, Loi, F, Migliaccio, M, Pagnanini, L, Piacentini, F, Pietrobon, D, Pusceddu, E, Sarritzu, V, Serra, M, Stellato, F, Tuveri, M, Fabio Agostini, Claudia Antolini, Pierpaolo Cacciotto, Matteo Cadeddu, Ester Casula, Giordano Cattani, Alessandro Cultrera, Marco Di Stefano, Carlo Flore, Edgardo Franzin, Luca Giovannelli, Elisa Incani, Francesca Loi, Marina Migliaccio, Lorenzo Pagnanini, Fabrizio Piacentini, Davide Pietrobon, Emanuela Pusceddu, Valerio Sarritzu, Matteo Serra, Francesco Stellato, Matteo Tuveri, Agostini, F, Antolini, C, Cacciotto, P, Cadeddu, M, Casula, E, Cattani, G, Cultrera, A, Di Stefano, M, Flore, C, Franzin, E, Giovannelli, L, Incani, E, Loi, F, Migliaccio, M, Pagnanini, L, Piacentini, F, Pietrobon, D, Pusceddu, E, Sarritzu, V, Serra, M, Stellato, F, Tuveri, M, Fabio Agostini, Claudia Antolini, Pierpaolo Cacciotto, Matteo Cadeddu, Ester Casula, Giordano Cattani, Alessandro Cultrera, Marco Di Stefano, Carlo Flore, Edgardo Franzin, Luca Giovannelli, Elisa Incani, Francesca Loi, Marina Migliaccio, Lorenzo Pagnanini, Fabrizio Piacentini, Davide Pietrobon, Emanuela Pusceddu, Valerio Sarritzu, Matteo Serra, Francesco Stellato, and Matteo Tuveri
Published: 2018

37. Bisphenol S, used as Bisphenol A alternative, accumulates in the fӕtal compartment throughout the gestation

Author: Grandin, Flore C., Lacroix, Marlène Z., Gayrard-Troy, Véronique, Viguié, Catherine, Toutain, Pierre-Louis, Picard-Hagen, Nicole, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Centre National de la Recherche Scientifique (CNRS). FRA., and ProdInra, Migration
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: National audience
Published: 2017

38. Disposition du Bisphénol S et de son principal métabolite dans l’unité materno-foeto-placentaire

Author: Grandin, Flore C., Lacroix, Marlène Z., Gayrard-Troy, Véronique V., Catherine Viguié, Pierre-Louis Toutain, Nicole Picard-Hagen, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Association Francaise d'Etudes et de Recherches sur l'Obesite (AFERO). FRA., and ProdInra, Migration
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: National audience
Published: 2017

39. Development of an on-line solid phase extraction ultra performance liquid chromatography technique coupled to tandem mass spectrometry for quantification of bisphenol S and bisphenol S glucuronide: applicability to toxicokinetic investigations

Author: Nicole Picard-Hagen, Véronique Gayrard, Flore C. Grandin, Marlène Z. Lacroix, Sylvie Puel, Catherine Viguié, Laurent Debrauwer, Pierre-Louis Toutain, ToxAlim (ToxAlim), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Biosynthèse & Toxicité des Mycotoxines (ToxAlim-BioToMyc), Analyse de Xénobiotiques, Identification, Métabolisme (E20 Metatoul-AXIOM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-MetaToul-MetaboHUB, Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-MetaToul-MetaboHUB, Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Lacroix, Marlène Z.
Subjects: Bisphenol A, Bioanalysis, bisphenol S glucuronide, bisphenol S, toxicokinetic, liquid chromatography, mass spectrometry, Metabolite, [SDV]Life Sciences [q-bio], 010501 environmental sciences, Tandem mass spectrometry, 01 natural sciences, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, Glucuronides, Phenols, Limit of Detection, Tandem Mass Spectrometry, Animals, Humans, Solid phase extraction, Sulfones, Chromatography, High Pressure Liquid, 0105 earth and related environmental sciences, Detection limit, Chromatography, Sheep, 010401 analytical chemistry, Organic Chemistry, Solid Phase Extraction, Reproducibility of Results, General Medicine, 0104 chemical sciences, 3. Good health, Toxicokinetics, Bisphenol S, chemistry, Glucuronide, Blood Chemical Analysis
Abstract: International audience; Regulatory measures and public concerns regarding bisphenol A (BPA) have led to its replacement by structural analogs, such as Bisphenol S (BPS), in consumer products. At present, no toxicokinetic investigations have been conducted to assess the factors determining human internal exposure to BPS for subsequent risk assessment. Toxicokinetic studies require reliable analytical methods to measure the plasma concentrations of BPS and its main conjugated metabolite, BPS - glucuronide (BPS - G). An efficient on - li ne SPE - UPLC - MS/MS method for the simultaneous quantification of BPS and BPS - G in ovine plasma was therefore developed and validated in accordance with the European Medicine s Agency guidelines for bioanalytical method validation. This method has a limit of quantification of 3 ng mL - 1 for BPS and 10 ng mL - 1 for BPS - G , a n analytical capacity of 200 samples per day, and is particularly well suited to toxicokinetic studies. Use of this method in toxicokinetic studies in sheep showed that BPS, like BPA, is efficiently metabolized into its glucuronide form . However, the clearance s and distribution s of BPS and BPS - G were lower than those of the corresponding unconjugated and glucuroconjugated forms of BPA .
Published: 2017

40. Bisphenol S instead of Bisphenol A: Toxicokinetic investigations in the ovine materno-feto-placental unit

Author: Grandin, Flore C., primary, Lacroix, Marlène Z., additional, Gayrard, Véronique, additional, Gauderat, Glenn, additional, Mila, Hanna, additional, Toutain, Pierre-Louis, additional, and Picard-Hagen, Nicole, additional
Published: 2018
Full Text: View/download PDF

41. Comment on ‘Pharmacokinetics of bisphenol S in humans after a single oral administration’

Author: Grandin, Flore C., primary, Gayrard, Véronique, additional, Lacroix, Marlène Z., additional, Picard-Hagen, Nicole, additional, Mila, Hanna, additional, and Toutain, Pierre-Louis, additional
Published: 2018
Full Text: View/download PDF

42. Assessing signals of TMD physics in SIDIS azimuthal asymmetries and in the extraction of the Sivers function

Author: Boglione, M., primary, D’Alesio, U., additional, Flore, C., additional, and Gonzalez-Hernandez, J. O., additional
Published: 2018
Full Text: View/download PDF

43. Linee Guida per la sorveglianza sanitaria degli esposti a piombo inorganico

Author: APOSTOLI P, ABBRITTI G, ALESSIO L, CARTA P, FLORE C, FOA V, SALA E, SOLEO L, MUZI G, MUTTI A., SANNOLO, Nicola, Apostoli, P, Abbritti, G, Alessio, L, Carta, P, Flore, C, Foa, V, Sala, E, Sannolo, Nicola, Soleo, L, Muzi, G, and Mutti, A.
Published: 2005

44. Biological monitoring of low-level exposure to benzene

Author: Campagna M, Satta G, Laura Campo, Flore V, Ibba A, Meloni M, Mg, Tocco, Avataneo G, Flore C, Fustinoni S, and Cocco P
Subjects: Adult, Male, Guanine, Time Factors, Urban Population, Air Pollutants, Occupational, Sensitivity and Specificity, Occupational Exposure, Humans, Cotinine, Aged, Air Pollutants, Inhalation Exposure, Guanosine, Osmolar Concentration, Smoking, Deoxyguanosine, Benzene, Middle Aged, Sorbic Acid, Acetylcysteine, Suburban Population, Italy, 8-Hydroxy-2'-Deoxyguanosine, Chemical Industry, Female, Biomarkers, Fuel Oils, Environmental Monitoring
Abstract: Conflicting opinions exist about the reliability of biomarkers of low-level exposure to benzene. We compared the ability of the urinary excretion of trans,trans-muconic acid (t,t-MA), s-phenilmercapturic acid (s-PAMA) and urinary benzene (U-Benz) to detect low level occupational and environmental exposure to benzene.We monitored airborne benzene by personal air sampling, and U-Benz, s-PMAI, t,t-MA and cotinine (U-Cotinine) in spot urine samples, collected at 8 am and 8 pm, in 32 oil refinery workers and 65 subjects, randomly selected among the general population of urban and suburban Cagliari, Italy. Information on personal characteristics, diet and events during the sampling day was acquired through in person interviews.The median concentration of airborne benzene was 25.2 microg/m3 in oil refinery workers, and 8.5 microg/m3 in the general population subgroup. U-Benz in morning and evening samples was significantly more elevated among oil refinery workers than the general population subgroup (p = 0.012, and p = 7.4 x 10(-7), respectively) and among current smokers compared to non-smokers (p = 5.2 x 10(-8), and p = 5.2 x 10(-5) respectively). Benzene biomarkers and their readings in the two sampling phases were well correlated to each other. The Spearman's correlation coefficient with airborne benzene was significant for U-Benz in the evening sample, while no correlation was seen with t,t-MA and s-PMA readings in either samplings. The two benzene metabolites were frequently below limit of detection (LOD), particularly among the general population study subjects (17-9% and 39%, for t,t-MA and s-PMA respectively). Morning U-Cotinine excretion showed a good correlation with U-Benz in the morning and in the evening sampling (p0.001), and with s-PMA in the evening sample (p0.001), but not with t,t-MA in either samplings. t,t-MA in the evening sample was the only biomarker showing a moderate inverse correlation with BMI (p0.05). The multiple regression analysis adjusting by BMI and number of cigarettes smoked during the day confirmed the results of the univariate analysis.Our results suggest that unmetabolized U-Benz would allow a more reliable biomonitoring of low-level exposure to benzene than s-PMA and t,t-MA.
Published: 2012

45. Linee Guida per la sorveglianza sanitaria degli esposti a piombo inorganico

Author: Abbritti, G, Alessio, Lorenzo, Carta, P, Flore, C, Foa', V, Sala, E, Sannolo, N, Soleo, L, Muzi, G, and Mutti, A.
Published: 2005

46. Presentazione delle attività svolte nell'ambito del progetto di ricerca MIUR 'Esposizione ambientale ed occupazionale a piombo inorganico: studio degli effetti tossici conseguenti alle dosi correnti e delle relative misure preventive'

Author: Apostoli, Pietro, Neri, Gloria, Alessio, Lorenzo, Carta, P, Flore, C, Alinovi, R, DE PALMA, Giuseppe, Mutti, A, Murgia, N, Muzi, G, Abbritti, G, Soleo, L, and Cassano, F.
Published: 2005

47. Piombo: indicatori di dose e di effetto sull'eme

Author: Neri, Gloria, Apostoli, Pietro, Catalani, Simona, Carta, P, Flore, C, Mutti, A, Murgia, N, Muzi, G, and Soleo, L.
Published: 2005

48. Lead: indicators of dose and effects on heme

Author: Neri, G., Apostoli, P., Catalani, S., Carta, P., Flore, C., Mutti, A., Murgia, Nicola, Muzi, Giacomo, and Soleo, L.
Subjects: acido aminolevulinico, biomarkers, medicina del lavoro
Published: 2005

49. Linee guida per la sorveglianza sanitaria degli esposti a piombo inorganico

Author: Apostoli, P., Abbritti, Giuseppe, Alessio, L., Carta, P., Flore, C., Foà, G., Sala, E., Sannolo, N., Soleo, L., Muzi, Giacomo, and Mutti, A.
Subjects: sorveglianza sanitaria, esposizione a piombo inorganico, medicina del lavoro
Published: 2005

50. Effects on neurological functions through fish eating as a function of methylmercury bioaccumulation

Author: Carta, P, Lucchini, Roberto, Flore, C, Ibba, A, Aru, G, Carta, R, Girei, M, Alessio, Lorenzo, and SANNA RANDACCIO, F.
Published: 2002

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