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Development of an on-line solid phase extraction ultra performance liquid chromatography technique coupled to tandem mass spectrometry for quantification of bisphenol S and bisphenol S glucuronide: applicability to toxicokinetic investigations
- Source :
- Journal of Chromatography A, Journal of Chromatography A, Elsevier, 2017, 1526, pp.39-46. ⟨10.1016/j.chroma.2017.10.020⟩, Journal of Chromatography. A (1526), 39-46. (2017)
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- International audience; Regulatory measures and public concerns regarding bisphenol A (BPA) have led to its replacement by structural analogs, such as Bisphenol S (BPS), in consumer products. At present, no toxicokinetic investigations have been conducted to assess the factors determining human internal exposure to BPS for subsequent risk assessment. Toxicokinetic studies require reliable analytical methods to measure the plasma concentrations of BPS and its main conjugated metabolite, BPS - glucuronide (BPS - G). An efficient on - li ne SPE - UPLC - MS/MS method for the simultaneous quantification of BPS and BPS - G in ovine plasma was therefore developed and validated in accordance with the European Medicine s Agency guidelines for bioanalytical method validation. This method has a limit of quantification of 3 ng mL - 1 for BPS and 10 ng mL - 1 for BPS - G , a n analytical capacity of 200 samples per day, and is particularly well suited to toxicokinetic studies. Use of this method in toxicokinetic studies in sheep showed that BPS, like BPA, is efficiently metabolized into its glucuronide form . However, the clearance s and distribution s of BPS and BPS - G were lower than those of the corresponding unconjugated and glucuroconjugated forms of BPA .
- Subjects :
- Bisphenol A
Bioanalysis
bisphenol S glucuronide
bisphenol S
toxicokinetic
liquid chromatography
mass spectrometry
Metabolite
[SDV]Life Sciences [q-bio]
010501 environmental sciences
Tandem mass spectrometry
01 natural sciences
Biochemistry
Analytical Chemistry
chemistry.chemical_compound
Glucuronides
Phenols
Limit of Detection
Tandem Mass Spectrometry
Animals
Humans
Solid phase extraction
Sulfones
Chromatography, High Pressure Liquid
0105 earth and related environmental sciences
Detection limit
Chromatography
Sheep
010401 analytical chemistry
Organic Chemistry
Solid Phase Extraction
Reproducibility of Results
General Medicine
0104 chemical sciences
3. Good health
Toxicokinetics
Bisphenol S
chemistry
Glucuronide
Blood Chemical Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 00219673 and 18733778
- Database :
- OpenAIRE
- Journal :
- Journal of Chromatography A, Journal of Chromatography A, Elsevier, 2017, 1526, pp.39-46. ⟨10.1016/j.chroma.2017.10.020⟩, Journal of Chromatography. A (1526), 39-46. (2017)
- Accession number :
- edsair.doi.dedup.....23b8d610ef0fd5ecc68f2276bb1ac682