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6. Maternal fetal medicine-perinatology

Author

Tekcan, C., Naki, M. M., Özcan, N., Cebi, M., Kanadikirik, F., Has, R., Aydoadu, M., Frenz, J. P., Schröder, W., Dede, F. S., Kovalak, E. E., Gelisen, O., Dede, H., Sariisik, B., Haberal, A., Caliskan, E., Turkoz, E., Corakci, A., Ozeren, S., Yucesoy, I., Terzioglu, N., Köhler, W., Feige, A., Atad, J., Auslender, R., Bardicef, M., Calderon, I., Leron, E., Abramovici, H., Ertas, I. F., Kahyaoglu, S., Turgay, M., Sut, N., Yilmaz, B., Ozel, M., Danisman, N., Kocak, I., Üstün, C., Bese, E., Ingec, M., Borekci, B., Yilmaz, M., Kadanali, S., Ingec, M., Kadanali, S., Erdogan, F., Kumtepe, Y., Gümüs, I. I., Turhan, N. O., Tamburaci, E., Gunduz, O., Akar, M., Simsek, M., Zorlu, G., Ingec, M., Borekci, B., Kadanali, S., Balci, O., Gezginc, K., Acar, A., Akyürek, C., Kocak, I., Üstün, C., Bese, E., Biri, A., Guler, I., Himmetoglu, O., Karaoguz, M. Y., Balci, Sevim, Tanriverdi, H. A., Usal, D., Cinar, E., Barut, A., Pilanci, B., Imren, A., Öztekin, D., Kurt, S., Tinar, S., Canoruc, N., Kale, A., Kale, E., Yalinkaya, A., Akdeniz, N., Gol, M., Tuna, B., Guclu, S., Altunyurt, S., Demir, N., Biri, A., Ciftci, B., Senol, E., Haznedarohlu, S., Gucuyener, K., Gursoy, R., Kahyaoglu, S., Turgay, I., Gocmen, M., Yilmaz, B., Neslihanoglu, R., Danisman, N., Kahyaoglu, S., Turgay, I., Gocmen, M., Yilmaz, B., Ozel, M., Danisman, N., Kahyaoglu, S., Turgay, I., Kokanali, M. K., Kunt, C., Yapar, E. G., Taskin, S., Yarci, A., Bozaci, E. A., Atabekoglu, C., Söylemez, F., Taskin, S., Seval, M., Bozaci, E. A., Özmen, B., Mammadova, S., Unlü, C., Seval, M., Taskin, S., Özmen, B., Güleryüz, D., Sahincioglu, Ö., Unlü, C., Öztürk, N., Yalvac, S., Caliskan, E., Erten, A., Dölen, I., Haberal, A., Gul, A., Cebeci, A., Gedikbasi, A., Erol, O., Ceylan, Y., Tekirdag, A. I., Onan, M. A., Turp, A., Kurdoglu, M., Gunaydin, G., Kurdoglu, Z., Guler, I., Erdem, A., Himmetoglu, O., Tulumbaci, O., Onan, M. A., Turkoglu, S., Kurdoglu, M., Boyaci, B., Tiras, M. B., Kurdoglu, Z., Gunaydin, G., Kadayifci, O., Demir, S. C., Ürünsak, I. F., Özgünen, T., Evrüke, I. C., Demir, S. C., Evrüke, I. C., Özgünen, T., Kadayifci, O., Güzel, A. B., Urünsak, I. F., Uckuyu, A., Ozcimen, E. E., Nisanoglu, O., Yanik, F., Akgun, S., Kuscu, E., Sayin, N. C., Canda, M. T., Ahmet, N., Kurt, I., Varol, F. G., Erkanli, S., Caliskan, K., Bagis, T., Kilicdag, E., Tarim, E., Kuscu, E., Tutuncu, L., Ardic, N., Mungen, E., Ergur, A. R., Yergok, Y. Z., Cölcimen, N., Sahin, H. G., Kamaci, M., Bezircioglu, I., Bicer, M., Uysal, D., Yigit, S., Baloglu, A., Bezircioglu, I., Bicer, M., Karci, L., Ozder, F., Baloglu, A., Has, R., Yüksel, A., Büyükkurt, S., Tatli, B., Kalelioglu, I., Kesim, M. D., Aydin, Y., Atis, A., Gezer, A., Erkan, S., Simsek, Y., Kahraman, N., Uludag, S., Altinok, T., Kale, A., Erdemoglu, M., Akdeniz, N., Ozcan, Y., Yalinkaya, A., Köse, G., Tuncel, T., Aka, N., Kumru, P., Güven, M. A., Ciragil, P., Tutuncu, L., Ozdemir, E., Mungen, E., Ergur, A. R., Yergok, Y. Z., Güven, M. A., Aktan, E., Bozkurt, K., Güven, M. A., Kilinc, M., Ekerbicer, H., Güven, M. A., Ceylaner, S., Ceylaner, G., Gul, D., Ertas, E., Güven, M. A., Ceylaner, S., Batukan, C., Ozbek, A., Demirpolat, G., Uzel, M., Basaran, A., Bozdag, G., Dagdelen, S., Gürlek, A., Beksac, S., Arici, Özkan A., Isparta, T., Dikis, F. C., Civas, S. B., Ispahi, C., Kalelioalu, I. K., Has, R., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Dane, B., Yayla, M., Dane, C., Özek, M., Kalelioglu, I. K., Has, R., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Dane, B., Yayla, M., Cem, Dane, Salih, Dural, Dane, C., Yayla, M., Dane, B., Cetin, A., Kiray, M., Dane, B., Yayla, M., Dane, C., Ataoglu, E., Döventas, Y., Delier, H., Has, R., Kalelioglu, I., Büyükkurt, S., Has, R., Kalelioglu, I. K., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Has, R., Kalelioglu, I. K., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Yildiz, A., Köksal, A., Celik, N., Yetimalar, H., Keklik, A., Ivit, H., Cukurova, K., Hizli, D., Dilbaz, S., Acer, N., Deveci, S., Dilbaz, B., Haberal, A., Cukurova, K., Köksal, A., Yilmaz, S., Ivit, H., Yildiz, A., Yetimalar, H., Keklik, A., Bicer, Bulbul M., Karakaya, E., Pehlivan, M., Baloglu, A., Caliskan, E., Doger, E., Duman, C., Turker, G., Ozeren, S., Yucesoy, I., Caliskan, E., Doger, E., Cakiroglu, Y., Corakci, A., Ozeren, S., Caliskan, E., Turkoz, E., Ozeren, S., Corakci, A., Ozkan, S., Yucesoy, I., Caliskan, E., Cakiroglu, Y., Dundar, D., Doger, E., Caliskan, S., Ozeren, S., Cukurova, K., Köksal, A., Ivit, H., Yetimalar, H., Yildiz, A., Keklik, A., Aksakalli, V., Cukurova, K., Köksal, A., Önal, G., Yildiz, A., Ivit, H., Keklik, A., Yetimalar, H., Kesim, M. D., Demirkaya, B. Ö., Atis, A., Yavuz, M., Bozkurt, T., Ozyuncu, O., Bozdag, G., Salman, M. C., Durukan, T., Beksac, S., Onderoglu, L., Deren, O., Ayhan, A., Tufekci, C., Karalök, H., Ilter, E., Cil, L., Karalök, A. E., Akyol, H., Kesim, M. D., Demirkaya, B. Ö., Atis, A., Oruc, Ö., Ekin, M., Ülku, M., Caglar, P., Demirel, C., Güngör, T., Mollamahmutoglu, L., Usta, T., Özdemir, B., Ates, U., Numanoglu, N., Seyhan, A., Sidal, B., Akdeniz, N., Kale, A., Erdemoglu, M., Ozcan, Y., Yalinkaya, A., Ozdemir, B., Numanoglu, N., Usta, T., Ortakuz, S., Seyhan, A., Sidal, B., Seyhan, A., Numanoglu, N., Usta, T., Ortakuz, S., Öztarhan, A., Özdemir, B., Dogan, O., Ilbaz, S., Kovalak, E. E., Tarcan, A., Sariisik, B., Sivaslioglu, A., Haberal, A., Cinar, E., Tanriverdi, H. A., Akbulut, V., Sade, H., Barut, A., Dede, A., Özel, M., Günaydin, S., Ertas, E., Danisman, N., Mollamahmutoglu, L., Ates, U., Seyhan, A., Atmaca, U., Ortakuz, S., Ata, B., Akar, S., Sidal, B., Tanriverdi, H. A., Akbulut, V., Usal, D., Cinar, E., Barut, A., Vural, B., Özkan, S., Costur, P., Dalcik, H., Filiz, S., Yücesoy, I., Erdemoglu, E., Kolusari, A., Sahin, H. G., Kamaci, M., Sahin, A. V., Vural, B., Özkan, S., Tas, A., Dalcik, C., Dalcik, H., Yücesoy, G., Unlubilgin, E., Caliskan, E., Demir, B., Dilbaz, S., Sonmezer, M., Haberal, A., Erdem, M., Turp, A., Gunaydin, G., Erdem, A., Sade, H., Tanriverdi, H. A., Gezer, S., Bayar, Ü., Barut, A., Demir, B., Demir, F., Yayla, M., Api, O., Aygün, E., Kars, B., Cengizoglu, B., Bulut, S., Turan, C., Unal, O., Api, O., Ünal, O., Karageyim, Y. K., Balcik, O., Kara, Ö., Dogance, U., Akil, A., Api, M., Balsak, D., Avci, M. E., Elveren, B., Hanhan, M., Kayhan, K., Tinar, S., Ispahi, C., Mollamahmutoglu, L., Güngör, T., Özdal, B., Cavkaytar, S., Özat, M., Demirel, C., Aksakal, O., Caliskan, E., Unlubilgin, E., Cakiroglu, Y., Dilbaz, B., Dilbaz, S., Dilbaz, S., Caliskan, E., Dilbaz, B., Ozdas, E., Filiz, T., Haberal, A., Asian, E., Tarim, E., Kilicdag, E., Haydardedeoglu, B., Kuscu, E., Asian, E., Kilicdag, E., Simsek, E., Bolat, F., Haydardedeoglu, B., Ocak, S., Zeteroglu, S., Deveci, A., Gungoren, A., Borazan, E., Hakverdi, A., Zeteroglu, S., Ocak, S., Deveci, A., Gungoren, A., Andi, A., and Hakverdi, A.

Published
2005
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9. Does It Matter How and How Much Politicians Are Paid?

Author

Altindag, Duha T., Filiz, S. Elif, and Tekin, Erdal

Subjects
J26, bonus, politician, Turkey, J22, J33, J45, ddc:330, MP, election, salary, members of the parliament, performance
Abstract

An important question in representative democracies is how to ensure that politicians behave in the best interest of citizens rather than their own private interests. Aside from elections, one of the few institutional devices available to regulate the actions of politicians is their pay structure. In this paper, we provide fresh insights into the impact of politician salaries on their performance using a unique law change implemented in 2012 in Turkey. Specifically, the members of the parliament (MPs) in Turkey who are retired from their pre-political career jobs earn a pension bonus on top of their MP salaries. The law change in 2012 significantly increased the pension bonus by pegging it to 18 percent of the salary of the President of Turkey, while keeping the salaries of non-retired MPs unchanged. By exploiting the variation in total salaries caused by the new law in a difference-in-differences framework, we find that the salary increase had a negative impact on the performance of the retired MPs. In particular, the overall performance of these MPs was lowered by 12.3 percent of a standard deviation as a result of the increase in salary caused by the new law. This finding is robust to numerous specification tests. Furthermore, the results obtained from an auxiliary analysis suggest that one of the mechanisms through which MPs reduce their performance is through absenteeism.

Published
2017

15. Growth and evolution in three Philadelphia artist collectives

Author

O'Brien, Filiz S.

Subjects
Art centers, Artistic collaboration, Arts--Management
Abstract

Three collectives located in Philadelphia, Pennsylvania are examined to uncover the critical issues affecting the success and direction of artist collectives. The purpose of this study is to better understand the Artist Cooperative movement as a visual art organizational model and to unveil the key aspects or components that allow the artist cooperative to grow and transform successfully throughout its life cycle. Through investigation of the histories of The Clay Studio, Nexus/Foundation for Today's Art, and Vox Populi, critical issues and trends are discovered contributing to these collectives success, including the necessity of artists as stakeholders, artists involvement in governance, and the availability of long-term affordable physical space.

Published
2012
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19. Hydrogeological, hydrochemical and isotopic survey of the Bayindir geothermal area (Izmir, western Anatolia, Turkey).

Author

Bulut M., Filiz S., Bulut M., and Filiz S.

Abstract

The Bayindir geothermal system is located to the northern margin of the Kucuk Menderes Graben. The reservoir rocks of the geothermal system are calc schists and marbles of Triassic metamorphic formation. The system is controlled by active graben faults. The geothermal field is of low enthalpy and the surface temperature of the hot waters is 42-46 degrees C. The temperature of the reservoir is 55-118 degrees C. Chemical and isotopic data indicate that the thermal waters are mixed with meteoric, shallow cycling and cold underground water. The Sariyurt Pb-Zn mineralisation, with probable reserves estimated in the 1970s as 860 000 tonnes grading 2.76% Pb and 3.7% Zn, is located in the collecting area but does not cause natural or artificial heavy metal pollution of the waters., The Bayindir geothermal system is located to the northern margin of the Kucuk Menderes Graben. The reservoir rocks of the geothermal system are calc schists and marbles of Triassic metamorphic formation. The system is controlled by active graben faults. The geothermal field is of low enthalpy and the surface temperature of the hot waters is 42-46 degrees C. The temperature of the reservoir is 55-118 degrees C. Chemical and isotopic data indicate that the thermal waters are mixed with meteoric, shallow cycling and cold underground water. The Sariyurt Pb-Zn mineralisation, with probable reserves estimated in the 1970s as 860 000 tonnes grading 2.76% Pb and 3.7% Zn, is located in the collecting area but does not cause natural or artificial heavy metal pollution of the waters.

Published
2005

22. Nucleation and growth in electrodeposition of thin copper films on pyrolytic graphite

Author

Filiz S. Kinaci and Rolf H. Muller

Subjects
Surface coating, Materials science, Highly oriented pyrolytic graphite, law, Nucleation, Analytical chemistry, Pyrolytic carbon, Graphite, Cyclic voltammetry, Overpotential, Scanning tunneling microscope, law.invention
Abstract

Electrodeposition of Cu on graphite electrodes was studied, with emphasis on nucleation. Various ex-situ and in-situ methods were investigated for determining the number density of nuclei. Two direct methods were studied (scanning electron microscopy and scanning tunneling microscopy); indirect determinations included Raman spectroscopy and analysis of potentiostatic current transients. Though some of the techniques correctly predicted the nucleation densities under special conditions, SEM was the most reliable tool. The large scatter in the data necessitated steps to minimize this effect. To electrodeposit Cu on graphite, a nucleation overpotential of 250 mV was measured with cyclic voltammetry; such a large overpotential does not occur on a Pt or on a Cu-covered graphite electrode. The deposition potential is the dominant parameter governing nucleation density. There is a sharp increase in the nucleation density with applied potential. Cu can be deposited on highly oriented pyrolytic graphite only between the nucleation overpotential and the hydrogen evolution potential. To increase the Cu nucleation density, while avoiding excessive H evolution, a double pulse potential technique was used; nucleation densities on the order of 10{sup 10} nuclei/cm{sup 2} were achieved. The use of inhibitors (PVA, benzotriazole) was also investigated. Deposition on conducting polymer electrodes was also studied;more » initial results with polyaniline show promise. 57 figs, 6 tabs, refs. (DLC)« less

Published
1992
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30. The demographic datas of chronic granulomatous disease patients and the comparation of the clinical datas before and after interferon-gamma treatment in our country

Author

Filiz, Serkan, Kocacık Uygun, Dilara Fatma, Sanal, Özden, Camcıoğlu, Yıldız, Somer, Ayper, Barlan, Işıl, Kılıç, Şebnem, Reisli, İsmail, Patıroğlu, Türkan, Yıldıran, Alişan, Artaç, Hasibe, Metin, Ayşe, Aksu, Güzide, Genel, Ferah, Öztürk, Can, Çelmeli, Fatih, Bingöl, Ayşen, Yeğin, Olcay, Dilara Fatma Kocacık Uygun: 0000-0002-7669-434X, Özden Sanal: 0000-0003-3463-7555, Yıldız Camcıoğlu: 0000-0002-4796-6828, Ayper Somer: 0000-0002-7827-1113, Şebnem Kılıç: 0000-0001-8571-2581, İsmail Reisli: 0000-0001-8247-6405, Alişan Yıldıran: 0000-0002-2918-6238, Hasibe Artaç: 0000-0002-9807-2605, Ayşe Metin: 0000-0002-0731-5799, Güzide Aksu: 0000-0003-2714-0903, Ferah Genel: 0000-0002-9976-067X, Fatih Çelmeli: 0000-0002-2983-5058, Ayşen Bingöl: 0000-0002-0886-3332, Reisli, İ., Filiz, S., Kocacık Uygun, D. F., Sanal, Ö., Camcıoğlu, Y., Somer, A., Barlan, I., Kılıç, Ş., Patıroğlu, T., Yıldıran, A., Artaç, H., Metin, A., Aksu, G., Genel, F., Öztürk, C., Çelmeli, F., Bingöl, A., Yeğin, O. (2013). Ülkemizde kronik granülomatöz hastalık tanılı olguların demografik verileri ve interferon-gama tedavisi öncesi ve sonrası klinik verilerinin karşılaştırılması. Astım Allerji İmmünoloji, 11, 3, 153-161., and Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü Çocuk Sağlığı ve Hastalıkları Anabilim Dalı

Subjects
İnterferon-gama, Immunologic diseases, İmmünolojik bozukluk
Abstract

Giriş: Kronik granülomatöz hastalık (KGH): Fagositik hücrelerin, bazı bakteri ve mantarları fagosite ettikten sonra öldürememesiyle karakterize heterojen, kalıtsal primer bir immünyetmezlik hastalığıdır. Doğal ve kazanılmış bağışıklık yanıtta rol oynayan interferon-gama (INF-), KGH tedavisinde uzun yıllardır kullanılmasına rağmen etkinliği hala tartışılmaktadır. Gereç ve Yöntem: Çalışmamızda, 14 immünoloji merkezinde KGH tanısıyla takip edilen toplam 57 hastanın demografik verileri, infeksiyöz ve granülomatöz komplikasyonlar gibi klinik bulgularına ait verileri, INF- tedavisi öncesi ve sonrası anket formları üzerinden değerlendirildi. Bulgular: Çalışmaya alınan 57 hastanın 14’ü kadın ve 43’ü erkekti. Yaş ortalaması 10.9 7.4 yıl iken tanı yaşı ortalaması ise 4.9 4.8 yıl olarak saptandı. Hastaların 56’sında akrabalık öyküsü ve 60’ında ise ailede primer immünyetmezlik (PİY) öyküsü vardı. Olguların %95’i trimetoprim-sülfametoksazol (TMP-SMX) ve %89.5’i itrakonazol tedavisi alırken %60’ı INF-? kullanıyordu. INF-? alanlarda, almayanlara göre ciddi infeksiyon, pnömoni, yumuşak doku infeksiyonu ve lenfadenit gibi infeksiyöz komplikasyonların sıklığının daha az olduğu görüldü. Ayrıca, INF-? alanlarda, aspergillozis infeksiyonu, organ apsesi, granülomatöz reaksiyon sıklığının daha az olduğu saptandı. Hastaların KGH alt tiplerine göre yıllık infeksiyöz komplikasyonları karşılaştırıldığında; gp91phox alt tipinde INF-? alan grupta infeksiyon sıklığının daha az olduğu görüldü. Sonuç: KGH’li olguların demografik ve klinik özelliklerini yansıtan çalışmamız göstermiştir ki, KGH’de INF profilaksisi tedavisi, infeksiyöz ve granülomatöz komplikasyon sıklığını azaltmakta ve bu tedavi özellikle gp91phox alt tipinde etkili olmaktadır., Objective: Chronic granulomatous disease (CGD) is a genetically heterogeneous primary immunodeficiency that is characterised by bacteria and fungal infections with defective phagocytosis. Interferongamma (INF-γ) has diverse roles in the innate and adaptive responses. Despite several decades of work on INF treatment in CGD, contraversy remains about its use. Materials and Methods: Fifty seven patients with CGD from 14 immunology centers were enrolled to our multi-center study. A questionnaire including patients demographic datas and clinical manifestations such as infectious and granulomatous complications up to enrolment was obtained before and after INF therapy. Results: Fifty seven patients 14 girls and 34 boys aged from 2-35 years were enrolled. The mean age of diagnosis were of the patient’s family had consanguineous marriage and 60 had a primary immunodeficiency history. Ninety five of the patients were treated with trimethoprim-sulfamethoxazole and 89.5 of them with itraconazol while 60 of them were received INF treatment. The patients receiving INF therapy tend to have lower infectious complications like severe infections, pneumonia, soft tissue infections and lymphadenitis. Aspergillus infection, tissue abcesses and granulomatous complications were also lower in this group. The annual infectious complications according to CGD subtypes, were also lower in gp91phox with receiving INF therapy. Conclusion: The demographic and clinical data of CGD patients in our study indicate that INF prophylaxis treatment decreases the infectious and granulomatous complications in some majority of CGD patients especially in gp91phox.

Published
2013

31. Investigation of Electromagnetic Wave Propagation in Photonic-like Welded Materials Using the Finite Element Method.

Author

Basmaci AN and Filiz S

Abstract

In this study, two identical and two dissimilar materials are conjoined by applying the friction welding method to yield various rods. This investigation's primary focus entails examining the repercussions associated with the heat-affected zone (HAZ) arising from elevated temperatures at the welding interfaces on the propagation of electromagnetic (EM) waves within the resultant structures. The study incorporates the photonic crystal approach in conjunction with Maxwell's equations, and the subsequent solution of the latter is executed using the finite element method. The subdivision of the structures into fifteen elements is predicated upon the assumption of the electromagnetic wave number of the m-th segment, k m , of discrete segments. The finite element method is then administered to the HAZ regions of the structures, wherein the HAZ is discretised into one, three, and five elements, respectively.

Published
2024
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32. Institutional clinical indication-based typical dose values of multiphasic abdominopelvic computed tomography examinations.

Author

Filiz S, Gürel S, and Gürel K

Abstract

Purpose: Our study aimed to obtain clinical indication-based typical dose values and size-specific dose estimates (SSDEs) for multiphasic abdominopelvic computed tomography (CT) examinations and to review our data with published diagnostic reference levels (DRLs)., Methods: In this retrospective study, multiphasic liver, kidney, pancreas, and mesenteric ischemia protocol CT scans performed at our center between January 2018 and December 2021 were analyzed. The clinical indications were hepatocellular carcinoma, renal cell carcinoma, pancreas adenocarcinoma, and mesenteric ischemia. The computed tomography dose index volume (CTDI vol ) and dose-length product (DLP) values were recorded, and the SSDE and effective dose (ED) values were calculated. The water-equivalent diameter (Dw) value required for the SSDE calculation was measured using the automated calculation of the Dw program., Results: The total number of patients was 514, with 86 patients excluded from this study. The dose values were calculated for 426 patients (183 female and 243 male; 111 liver, 120 kidney, 85 pancreas, and 110 mesenteric). The median values for the CTDI vol , DLP, SSDE, and ED were 6.86 mGy, 683.02 mGy. cm, 8.75 mGy, and 10.45 mSv for the liver CT; 8.37 mGy, 908.37 mGy.cm, 10.37 mGy, and 13.89 mSv for the kidney CT; 7.82 mGy, 517.98 mGy.cm, 10.01 mGy, and 7.92 mSv for the pancreas CT; and 9.48 mGy, 983.68 mGy.cm, 12.78 mGy, and 13.86 mSv for the mesenteric CT, respectively. All dose values were lower than the published DRLs., Conclusion: The literature reveals large differences in the multiphasic abdominopelvic CT protocols, especially in the number of phases and scan length. This situation makes comparing dose values difficult. Dose studies revealing the protocol parameters in detail are needed so that institutions can compare and optimize their own protocols. Additionally, users should periodically check the dose values in their own institutions.

Published
2024
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33. Effects of lumbar lordosis increment on gait deteriorations in ambulant boys with Duchenne Muscular Dystrophy: A cross-sectional study.

Author

Filiz MB, Toraman NF, Kutluk MG, Filiz S, Doğan ŞK, Çakır T, and Yaman A

Subjects
Cross-Sectional Studies, Gait, Humans, Male, Spine, Kyphosis, Lordosis, Muscular Dystrophy, Duchenne
Abstract

Background: Increment of lumbar lordosis, a frequent spinal finding in Duchenne Muscular Dystrophy (DMD), is a compensatory mechanism secondary to muscle weakness. However, excessive lumbar lordosis may change the position of the center of mass, and lead to balance and walking difficulties., Objective: To study the relationship between factors that may influence ambulatory function in boys with DMD and to investigate the effects of lumbar lordosis increment on gait and balance perturbations., Methods: Twenty-one ambulant patients with DMD and 10 healthy boys were included. Lumbar lordosis and thoracic kyphosis angles, dynamic and static balance tests, ambulatory function, muscle strength, and disease severity were assessed. Usage of steroids and orthotic devices were recorded. Scoliosis was assessed on radiographs. Receiver operator characteristic curves were formed and area under curve (AUC) measurements were performed to assess the ability of the tests to discriminate ambulatory status and optimal cut-off values were established according to the Youden index., Results: The amount of lumbar lordosis correlated strongly and negatively with quality of ambulation (r = -0.710) and moderately with performance on balance tests. The strength of both upper limbs and lower limbs muscles were not associated with any of the variables. According to the AUC analysis, patients with a lumbar lordosis higher than 36° had worse scores on gait and dynamic balance tests., Conclusion: Ambulation and dynamic balance are negatively affected by the increment of lumbar lordosis with a cut-off point of 36°in boys with DMD., Competing Interests: Conflicts of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia. Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2021
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34. THE EFFECTS OF ETANERCEPT AND CABERGOLINE ON ENDOMETRIOTIC IMPLANTS, UTERUS AND OVARIES IN RAT ENDOMETRIOSIS MODEL.

Author

Keleş CD, Vural B, Filiz S, Vural F, Gacar G, Eraldemir FC, and Kurnaz S

Subjects
Animals, Disease Models, Animal, Drug Evaluation, Preclinical, Drug Therapy, Combination, Endometriosis immunology, Endometriosis pathology, Endometrium immunology, Endometrium pathology, Female, Humans, Ovary drug effects, Ovary immunology, Ovary pathology, Rats, Tumor Necrosis Factor-alpha metabolism, Vascular Endothelial Growth Factor A analysis, Vascular Endothelial Growth Factor A metabolism, Cabergoline administration & dosage, Endometriosis drug therapy, Endometrium drug effects, Etanercept administration & dosage
Abstract

The pathophysiology of endometriosis is still unknown and treatment options remain controversial. Searches focus on angiogenesis, stem cells, immunologic and inflammatory factors. This study investigated the effects of etanercept and cabergoline on ovaries, ectopic, and eutopic endometrium in an endometriosis rat model. This randomized, placebo-controlled, blinded study included 50 rats, Co(control), Sh(Sham), Cb(cabergoline), E(etanercept), and E + Cb(etanercept + cabergoline) groups. After surgical induction of endometriosis, 2 nd operation was performed for endometriotic volume and AMH level. After 15 days of treatment: AMH level, flow cytometry, implant volume, histologic scores, immunohistochemical staining of ectopic, eutopic endometrium, and ovary were evaluated at 3 rd operation. All groups had significantly reduced volume, TNF-α, VEGF, and CD 146/PDGF-Rβ staining of endometriotic implants comparing to the Sh group (p < 0.05).TNF-α staining of eutopic endometrium in all treatment groups was similar to Sh and Co groups (p > 0.05). E and E + Cb groups significantly decreased TNF-α staining in the ovary comparing to Sh, Co, and Cb groups (p < 0.05). All treatment groups had significantly higher AFC compared to the Sh group. CD25 + Cells' median percentage was significantly increased in the E + Cb group compared to Co, Sh, Cb, and E group. E + Cb group had a significantly higher CD5 + Cells' level than the Co group (p = 0.035). In conclusion; Etanercept and/or Cabergoline decreased volume, TNF-α, VEGF, and CD 146/PDGF-Rβ staining of the ectopic endometrial implant. E and E + Cb treatment decreased TNF-α levels in the ovary. E + Cb also increased peripheral blood CD25 + & CD5 + Cell's., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Published
2021
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35. Comparison of nasal airway obstruction with sonoelastography and nose obstruction symptom evaluation scores in children with allergic rhinitis.

Author

Filiz S, Özkan MB, Selçuk ÖT, and Çekiç B

Abstract

Objective: Nasal airway obstruction caused by inferior turbinate hypertrophy is the most troublesome symptom for patients with allergic rhinitis. The aim of this study was to determine any correlation between different nasal obstruction measurements in children with allergic rhinitis., Material and Methods: Nasal airway obstruction was assessed with Sonoelastography, Turkish version of the Nose Obstruction Symptom Evaluation scale, Rhinoconjunctivitis Total Symptom Score and visual analog scale methods in children with allergic rhinitis and the results were compared with a healthy control group., Results: Evaluation was made of a total of 68 patients (40 boys and 28 girls [male: female ratio, 1.42]) with a mean age of 13.35±3.35 (range, 7-18) years. The Rhinoconjunctivitis Total Symptom Score, visual analog scale, and Turkish version of the Nose Obstruction Symptom Evaluation scale scores were significantly higher in the AR group than in the control group (p=0.001, p=0.001, p=0.001, respectively). The sonoelastography scores were significantly higher in the AR group than in the control group (p=0.001). Although a positive significant correlation was determined between Rhinoconjunctivitis Total Symptom Score, visual analog scale, and Turkish version of the Nose Obstruction Symptom Evaluation scale scores in terms of AR severity, no relationship was found with the sonoelastography scores (p=0.022, p=0.009, p=0.001, and p=0.0751, respectively)., Conclusion: The Turkish version of the Nose Obstruction Symptom Evaluation scale and sonoelastography can be used to evaluate nasal obstruction due to inferior turbinate hypertrophy in children with allergic rhinitis., Competing Interests: Conflict of Interest: The authors have no conflicts of interest to declare., (Copyright © 2021 Turkish Pediatric Association.)

Published
2021
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36. The association of seminal oxidation reduction potential with sperm parameters in patients with unexplained and male factor ınfertility.

Author

Cicek OSY, Kaya G, Alyuruk B, Doger E, Girisen T, and Filiz S

Subjects
Humans, Male, Oxidation-Reduction, Retrospective Studies, Semen, Sperm Count, Spermatozoa, Infertility, Male, Sperm Motility
Abstract

Purpose: Understanding the effects of high oxidation reduction potential (ORP) levels on sperm parameters will help to identify patients with unexplained and male factor infertility who may have seminal oxidative stress and determine if ORP testing is needed. This study aimed to evaluate the association between seminal ORP and conventional sperm parameters., Materials and Methods: A total of 58 patients who provided a semen sample for simultaneous evaluation of sperm parameters and ORP between January and September 2019 were enrolled in this retrospective study. To identify normal and high ORP levels, a static ORP (sORP) cut-off value of 1.36mV/106sperm/mL was used. Sperm parameters were compared between infertile men with normal sORP (control group, n=23) and high sORP values (study group, n=35)., Results: Men with sORP values >1.36mV/106sperm/mL had significantly lower total sperm count (TSC) (p <0.001), sperm concentration (p <0.001) and total motile sperm count (TMSC) (p <0.001). In addition, progressive motility (p=0.04) and fast forward progressive motility (p <0.001) were significantly lower in the study group. A negative correlation was found between sORP and TSC (r=-0.820, p <0.001), sperm concentration (r=-0.822, p <0.001), TMSC (r=-0.808, p <0.001) and progressive motility (r=-0.378, p=0.004). Non-progressive motility positively correlated with sORP (r=0.344, p=0.010)., Conclusions: This study has shown that TSC, sperm concentration, progressive motility and TMSC are associated with seminal oxidative stress, indicated by a sORP cut-off of 1.36mV/106sperm/mL. Presence of oligozoospermia, reduced progressive motilty or low TMSC in sperm analysis should raise the suspicion of oxidative stress and warrants seminal ROS testing., Competing Interests: None declared., (Copyright® by the International Brazilian Journal of Urology.)

Published
2021
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37. Role of the Th1 and Th17 Pathway in Subacute Sclerosing Panencephalitis.

Author

Uygun DFK, Uygun V, Burgucu D, Ekinci NÇ, Sallakçı N, Filiz S, Köksoy S, Haspolat Ş, and Yeğin O

Subjects
Adolescent, Child, Female, Humans, Leukocytes, Mononuclear immunology, Male, Measles virus immunology, Subacute Sclerosing Panencephalitis drug therapy, Viral Proteins immunology, Interferon-gamma metabolism, Interleukins metabolism, Subacute Sclerosing Panencephalitis immunology
Abstract

Subacute sclerosing panencephalitis (SSPE) is a progressive and fatal disease caused by reactivation of a mutated measles virus in brain tissue. The process of reactivation is yet to be elucidated. In this study, the possible roles of the Th1 (interleukin [IL]-12, interferon [IFN]-γ) and the Th17 axis (IL-23, IL-17, IL-22), particularly of IL-17, in the pathogenesis of SSPE were investigated. Briefly, mononuclear cells from SSPE patients were stimulated using measles virus peptide, and the release of IL-12, IL-23, IL-22, IFN-γ, and IL-17 cytokines was measured using enzyme-linked immunosorbent assay and/or enzyme-linked immunosorbent spot assay (ELISpot). We found that in comparison to the mononuclear cells obtained from healthy donors, cells from SSPE patients exhibited increased levels of IL-12, IL-23, IL-17, IL-22, and IFN-γ cytokines in response to measles virus stimulation. However, the same result was not obtained with cytomegalovirus and phytohemagglutinin. Using flow cytometry, mononuclear cells obtained from SSPE patients and healthy controls were also analyzed for the presence of intracellular IL-17 in response to measles virus stimulation. On stimulation, the number of IL-17-positive cells were found to be higher among mononuclear cells obtained from the patients. In addition, the numbers of IL-17- and IFN-γ-positive cells were significantly increased in SSPE patients. In conclusion, this study demonstrates that both the IL-12/IFN-γ and the IL-23/IL-17/IL-22 pathways are functionally abnormal in SSPE pathogenesis. Targeting these pathways and their specific pro-inflammatory mediator production may provide a new strategy to suppress SSPE development.

Published
2019
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38. Evaluation of Pediatric Voice Handicap Index in Children With Allergic Rhinitis.

Author

Filiz S, Selçuk ÖT, and Baran RT

Subjects
Adolescent, Age Factors, Case-Control Studies, Child, Cross-Sectional Studies, Female, Humans, Male, Otolaryngologists, Predictive Value of Tests, Rhinitis, Allergic diagnosis, Risk Factors, Severity of Illness Index, Voice Disorders etiology, Voice Disorders physiopathology, Disability Evaluation, Rhinitis, Allergic complications, Voice Disorders diagnosis, Voice Quality
Abstract

Objective: The study sought to determine impact of voice disability on children with allergic rhinitis (AR). The Turkish version of the Pediatric Voice Handicap Index (pVHI) was used to assess the impact of voice disability on functional, physical, and emotional aspects of voice and oral communication. The degree of talkativeness was also determined., Methods: One hundred twenty-three children with AR aged 6-17 years and age-matched 84 children of controls without present or past record of voice disorder were admitted in the cross-sectional study. The pVHI was carried out by an otolaryngologist., Results: Children with AR show higher scores on pVHI compared to healthy children, indicating a greater chance of voice disorders observed in them (P < 0.001). The scores of three domains and total score of pVHI were prevalent in children with AR. In addition, as the severity of AR increased, high scores of pVHI were observed (P = 0.044). The mean talkativeness scores in AR group were lower than those of the healthy controls (P < 0.001)., Conclusion: In children with AR, voice disorders are more frequently observed and correlate positively with AR severity., (Copyright © 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)

Published
2019
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39. An evaluation of banana allergy in children living in the Mediterranean region

Author

Kocacık Uygun DF, Filiz S, and Bingöl A

Abstract

Background/aim: We aimed to apply a double-blind placebo-controlled food challenge (DBPCFC) test to patients who reported a reaction to banana and showed positivity for banana-specific IgE in Turkey. Materials and methods: Medical data of patients who had been analyzed for banana allergy were reviewed, focusing on banana-specific IgE positivity at the Department of Pediatric Allergy-Immunology at the Akdeniz University Faculty of Medicine between the years 2004 and 2012. Patients were called to the clinic for a DBPCFC test. Results: A total of 47 patients participated. We determined reactions in 13% of DBPCFC patients. A cut-off value was determined as 0.66 kU/L for banana-specific IgE, and sensitivity and specificity were 83% and 51%, respectively. The positive predictive value for specific IgE was 20% while the negative predictive value was 96%. Sensitivity and specificity for banana prick-to-prick test (P + P) was 33% and 93%, respectively; positive predictive value was 40% and negative predictive value was 91%. Conclusion: This is the first study conducted in Turkey to use a DBPCFC test in the diagnosis of banana allergy. Up until now, the positive predictive value was not defined for banana-specific IgE. Our study showed that specific IgE or skin tests alone are not adequate for the diagnosis of food allergy; to define subjective symptoms related to food and to determine cross-reactions, DBPCFC tests should be done for confirmation.

Published
2018
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40. Restless Legs Syndrome and Poor Sleep Quality in Obese Children and Adolescents

Author

Baran RT, Atar M, Pirgon Ö, Filiz S, and Filiz M

Subjects
Adolescent, Child, Comorbidity, Female, Humans, Male, Turkey epidemiology, Pediatric Obesity epidemiology, Restless Legs Syndrome epidemiology, Sleep Wake Disorders epidemiology
Abstract

Objective: Adult epidemiological studies suggest that the rate of Restless Legs syndrome (RLS) in the general population may range from 5% to 15%. The aim of this study was to investigate the frequency of RLS in a community sample of obese adolescents aged 10-16 years and to assess the association with sleep quality and health-related glucose metabolism markers., Methods: The study group comprised 144 obese and overweight children aged 10-16 yearsand the control group consisted of 66 age-matched healthy children. The RLS Questionnaire devised by the International RLS Study and the Pittsburgh Sleep Quality Index (PSQI), where a score >5 indicates poor sleep quality, was used to assess sleep quality., Results: Mean body mass index (BMI) of the overweight/obese and control groups were 30.5±0.5 and 18.7±0.2, respectively. The frequency of RLS was higher in the obese group (21.7%) than the overweight (3.4%) and control (1.5%) (p<0.001) groups. The frequency of a poor PSQI score was significantly higher (p<0.001) in the obese group (37.3%) than the control group (24.2%). The obese with RLS group also had poorer sleep quality scores than the non-RLS obese group. Many symptoms of sleep disruption were more common in obese patients with RLS and RLS was independently correlated with a high PSQI score [odds ratio (OR): 2.25, confidence interval (Cl): 0.96-5.28, p<0.001)] and an increased BMI z-score (OR: 8.87, Cl: 2.04-38.61, p<0.001)., Conclusion: RLS is common in obese children and may be associated with altered sleep quality. Obese children with RLS need to be assessed since they may need support to improve their sleep quality.

Published
2018
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41. Restless legs syndrome in children with allergic rhinitis: A comparative study on frequency, severity and sleep quality.

Author

Bilgilisoy Filiz M, Filiz S, Baran RT, Çakır T, Koldaş Doğan Ş, Parlak M, and Toraman NF

Abstract

Objectives: This study aims to investigate the frequency and severity of restless legs syndrome (RLS) and its relationship with sleep quality in children with allergic rhinitis (AR) with the hypothesis that comorbid RLS may be an additional causative factor of sleep disturbances in pediatric AR., Patients and Methods: A total of 143 children with AR (aged 8-18 years) and 144 healthy control subjects (aged 8-18 years) were included. The diagnosis of AR was established on history, clinical examination and skin prick test according to the Allergic Rhinitis and its Impact on Asthma guidelines. Presence of RLS was determined using the International RLS study group (IRLSSG) criteria. The severity of RLS was assessed using the IRLSSG rating scale. Sleep quality was evaluated by Pittsburgh Sleep Quality Index (PSQI)., Results: Thirteen patients (9.1%) in AR group, and six children (4.2%) in control group had RLS (p=0.159). The frequency of RLS in AR group was higher than two folds when compared to the control group; however, the difference was not statistically significant. Restless legs syndrome severity score was significantly higher in AR group than control group (15.00 [11-20] and 11.00 [10-16] respectively, p=0.046). Total PSQI scores were similar between groups. Also, no significant differences were observed in total PSQI scores of AR patients with or without RLS., Conclusion: Restless legs syndrome was not more common but was more severe in children with AR. There was no evidence that RLS has an obvious effect on sleep quality in children with AR., Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Published
2018
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42. Is orienteering associated with allergic rhinitis in adolescents?

Author

Selcuk OT, Eraslan A, Filiz S, Renda L, Selcuk NT, Eyigor H, Osma U, and Yilmaz MD

Subjects
Adolescent, Athletic Performance physiology, Basketball, Child, Female, Humans, Incidence, Male, Orientation, Spatial physiology, Prospective Studies, Risk Factors, Skin Tests statistics & numerical data, Athletes statistics & numerical data, Rhinitis, Allergic epidemiology, Sports
Abstract

Background: Allergic rhinitis (AR) is a disease that reduces athletic performance. Environmental allergen exposure is higher in outdoor sports (such as orienteering) than indoor sports. The main purpose of this study was to investigate the AR frequency in orienteers comparing with indoor athletes., Methods: Sixty adolescent athletes (33 orienteers, 27 basketball players) enrolled this prospective study. AR diagnosis was made by both history (ISAAC questionnaire) and physical examination. Nasal endoscopy was performed to observe objective findings (concha hypertrophy, mucosal paleness, serosity, septum deviation, adenoid hypertrophy). Epidermal prick test, pulmonary function test, total IgE and serum eosinophil levels were also assessed., Results: AR was diagnosed in 21 (35%) athletes. 14 (42.4%) were orienteers and 7 (25.9%) were basketball players (P=0.144). Endoscopic findings and skin test positivity were also seen at higher percentages in orienteers with no significance. Training age (sport duration), total IgE levels and skin test positivity were significantly higher in rhinitic orieenters than non-rhinitic orieenters (P=0.046, P=0.0001, and P=0.004, respectively)., Conclusions: Although adolescent orieenters had some higher allergic parameters than indoor athletes, they were not found more susceptible to AR. It seems that the frequency of AR increases with longer training age in orieentering sport. This study is the first report about AR in adolescent orienteers. Future researchs should more focus on comparing allergic conditions between outdoor and indoor sports.

Published
2017
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43. Do antithyroid antibodies affect hearing outcomes in patients with pediatric euthyroid Hashimoto's thyroiditis?

Author

Renda L, Parlak M, Selçuk ÖT, Renda R, Eyigör H, Yılmaz MD, Osma Ü, and Filiz S

Subjects
Acoustic Impedance Tests, Adolescent, Audiometry, Pure-Tone, Auditory Threshold, Autoantibodies, Case-Control Studies, Child, Female, Hearing Loss diagnosis, Humans, Male, Otoacoustic Emissions, Spontaneous, Otoscopy, Hashimoto Disease complications, Hashimoto Disease physiopathology, Hearing Loss etiology
Abstract

Objectives: Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease in children. HT is a multifaceted disease with a variable clinicopathological presentation, including hearing impairment. It is known that hearing function is negatively affected in patients with thyroid disorders. The literature includes a very limited number of studies on hearing function in euthyroid pediatric patients with HT. The aim of this study was to determine the relationship between cochlear function and HT, independent of thyroid function., Materials and Methods: The study included 48 children and adolescents (42 females and 6 males) aged 9-18 years that were diagnosed as HT, and 30 gender- and age-matched healthy controls. Hearing was assessed via otoscopy, tympanometry, pure-tone audiometry, and measurement of distortion product otoacoustic emissions., Results: There weren't any significant differences in pure tone thresholds between the 2 groups based on pure-tone audiometry, except in the right ear at 6kHz and 8kHz. Distortion product otoacoustic emissions signal to noise ratios were significantly lower in the HT group than in the control group at 4 different frequencies (6kHz [left ear], 8kHz [left ear], 1.5kHz [right ear], and 6kHz [right ear]) (P<0.05). The signal to noise ratios at all frequencies were <6dB in 3% of left ears and 2.5% of right ears in the control group, versus 12.5% of left ears and 9.6% of right ears in the HT group. Distortion product amplitudes were significantly lower in the HT group than in the control group for both left and right ears at 1kHz, 1.5kHz, 3kHz, and 8kHz, and at 2kHz for left ears only (P<0.05)., Conclusions: The present findings show that cochlear function was lower in the HT group than in the control group. Accordingly, we think that hearing in patients with HT should be monitored periodically, even if their hearing thresholds are within normal limits. Thyroid autoimmunity appears to play an important role in a decrease in cochlear activity in pediatric HT patients., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)

Published
2015
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44. Incidence and follow-up outcomes of developmental hip dysplasia of newborns in the Western Mediterranean Region.

Author

Çekiç B, Erdem-Toslak İ, Sertkaya Ö, Filiz S, Kılar Y, Köroğlu M, and Köse Ö

Subjects
Female, Follow-Up Studies, Hip Dislocation, Congenital diagnostic imaging, Hip Joint diagnostic imaging, Humans, Incidence, Infant, Infant, Newborn, Male, Prognosis, Prospective Studies, Turkey epidemiology, Ultrasonography methods, Hip Dislocation, Congenital epidemiology, Hip Joint abnormalities
Abstract

The aim of our study was to determine the incidence of developmental hip dysplasia (DHD) in the Western Mediterranean Region of Turkey and evaluate follow-up results of physiologically immature hips classified as type 2 according to Graf classification. Ultrasononographic examinations of the hips were performed using Graf's technique on 1162 infants (2324 hips) referred to our clinic for hip ultrasounds between March 2013 and March 2014. DHD was detected in 1.36% of 1162 infants. Among infants who were brought into repetitive follow-ups, 191 out of type 2a hip displasias of 201 infants were improved to type 1 and 10 type 2a hip dysplasias worsened. Sonographically worsened tip 2a group consisted of 4 type 2b, 6 type 2c DHDs. Hip ultrasound performed during neonatal period and infancy in the detection of developmental hip dysplasias and follow-up of hip dysplasias diagnosed as type 2a convey importance because of sonographically detected potential deterioration.

Published
2015

45. In vitro interferon γ improves the oxidative burst activity of neutrophils in patients with chronic granulomatous disease with a subtype of gp91phox deficiency.

Author

Filiz S, Uygun DF, Köksoy S, Şahin E, and Yeğin O

Abstract

Aim of This Study: Chronic granulomatous disease (CGD) is a genetically heterogeneous primary immunodeficiency caused by a defect in phagocyte production of oxygen metabolites, and resulting in infections produced by catalase-positive microorganisms and fungi. Interferon γ (IFN-γ) has a multitude of effects on the immune system. Although preliminary studies with CGD patients on treatment with IFN-γ showed that it enhanced phagocytosis and superoxide production, ongoing studies did not reveal a significant increase of this function. Here we investigated the oxidative capacity of phagocytes in different subtypes of CGD patients on treatment with IFN-γ in vitro., Material and Methods: Fifty-seven patients with CGD from 14 immunology centres were enrolled to our multi-centre study. Twenty-one patients were studied as controls. Oxidative burst assay with dihydrorhodamine 123 (DHR) was used and the stimulation index (SI) was calculated with respect to CGD subtypes in both neutrophils and monocytes before, and then one and 24 hours after adding IFN-γ., Results: Upon comparison of the SIs of the patients' neutrophils before in vitro IFN-γ at hour 0, and after adding IFN-γ at hour 1 and 24 were compared, and the differences were determined between hours 0-24 and hours 1-24. This difference was especially apparent between hours 1-24. In CGD subtypes, particularly in gp91phox subtype, it was seen that, following in vitro IFN-γ, SIs of neutrophils began to increase after hour 1, and that increase became more apparent at hour 24., Conclusions: Our study showed that IFN-γ treatment may increase the oxidative bursting activity by increasing the superoxide production in neutrophils, particularly in gp91phox subtype.

Published
2015
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46. Hormonal and functional biomarkers in ovarian response.

Author

Vural B, Cakiroglu Y, Vural F, and Filiz S

Subjects
Adult, Age Factors, Biomarkers blood, Female, Follicle Stimulating Hormone blood, Humans, Linear Models, Oocyte Retrieval, Pregnancy, Retrospective Studies, Ultrasonography, Anti-Mullerian Hormone blood, Fertilization in Vitro, Ovarian Follicle diagnostic imaging, Pregnancy Rate
Abstract

Purpose: Success rates of any artificial reproduction techniques depend on a correct protocol for ovarian stimulation. This can be decided only by proper assessment of ovarian reserve before commencing ovarian stimulation. This study has been conducted to investigate the role of hormonal and functional biomarkers in the prediction of ovarian response., Methods: A total of 689 women between July 2012 and July 2013 undergoing IVF at Kocaeli University have been enrolled in the study. Patients have been categorized into three groups according to the number of oocytes retrieved: 0-3 oocytes (poor responders), 4-15 oocytes (normoresponders), and >16 oocytes (hyperresponders). Groups have been compared according to follicle-stimulating hormone (FSH), E2, luteinizing hormone (LH) levels, antral follicle counts, and E2 levels on hCG days. Furthermore, regression analysis has been performed with parameters such as age, FSH, LH, E2, anti-mullerian hormone (AMH) and antral follicle counts (AFC) that can affect the total number of oocytes retrieved and pregnancy rates and their interactions with each other have been investigated., Results: FSH, age, hCG day LH level, cycle cancellation rate, total gonadotropin dose were significantly higher in the poor responder group, but in this group, AFC, AMH, hCG day E2 level, and the number of MII oocytes were significantly lower. Cut-off values of normal responders for FSH, AMH, and AFC were 8.43 area under curve [AUC: 0.541 (0.491-0.590)], 0.62 [AUC: 0.704 (0.638-0.764)], and 6 [AUC: 0.715 (0.667-0.760)], respectively. Cut-off values for the absolute poor response group (cycle cancellation) were 12.75 for FSH [AUC: 0.533 (0.49-0.57)], 0.23 for AMH [AUC: 0.678 (0.618-0.733)], and 6 for AFC [AUC: 0.576 (0.531-0.613)]. AMH and AFC were the best markers for the prediction of total oocyte count, independent of age, FSH, and LH levels., Conclusions: AMH and AFC were found to be the best ovarian reserve tests that can determine the total oocyte count retrieved, without any significant effects on pregnancy rates.

Published
2014
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47. Cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis in a child with interleukin-12 receptor beta-1 deficiency.

Author

Filiz S, Kocacik Uygun DF, Verhard EM, van Dissel JT, Uygun V, Bassorgun C, Bingol A, Yegin O, and van de Vosse E

Subjects
Anti-Bacterial Agents therapeutic use, Biopsy, Ceftriaxone therapeutic use, Child, Preschool, Female, Genetic Predisposition to Disease, Humans, Vasculitis, Leukocytoclastic, Cutaneous drug therapy, Vasculitis, Leukocytoclastic, Cutaneous genetics, Receptors, Interleukin-12 deficiency, Salmonella enteritidis isolation & purification, Vasculitis, Leukocytoclastic, Cutaneous microbiology
Abstract

Defects in the interleukin 12 (IL-12)/interferon gamma (IFN-γ) pathway result in Mendelian susceptibility to mycobacterial disease (MSMD). IL-12 receptor beta 1 (IL-12Rβ1) deficiency, the most common form of MSMD, is associated with weakly virulent mycobacteria and salmonella. Infections in patients with this deficiency are extraintestinal, or septicemic, recurrent infections with nontyphoid salmonellae. Here we report a case of an IL-12Rβ1 deficiency with cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis., (© 2012 Wiley Periodicals, Inc.)

Published
2014
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48. Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation.

Author

Engelhardt KR, Shah N, Faizura-Yeop I, Kocacik Uygun DF, Frede N, Muise AM, Shteyer E, Filiz S, Chee R, Elawad M, Hartmann B, Arkwright PD, Dvorak C, Klein C, Puck JM, Grimbacher B, and Glocker EO

Subjects
Adult, Child, Child, Preschool, Colitis diagnosis, Colitis etiology, Colitis genetics, Female, Humans, Immunologic Deficiency Syndromes complications, Immunologic Deficiency Syndromes diagnosis, Immunologic Deficiency Syndromes genetics, Infant, Infant, Newborn, Male, Mutation, Colitis therapy, Hematopoietic Stem Cell Transplantation, Immunologic Deficiency Syndromes therapy, Interleukin-10 deficiency, Receptors, Interleukin-10 deficiency
Abstract

Background: Inherited deficiencies of IL-10 or IL-10 receptor (IL-10R) lead to immune dysregulation with life-threatening early-onset enterocolitis., Objectives: We sought to gather clinical data of IL-10/IL-10R-deficient patients and devise guidelines for diagnosis and management, including hematopoietic stem cell transplantation (HSCT)., Methods: We enrolled 40 patients with early-onset enterocolitis and screened for mutations in IL10/IL10R using genetic studies, functional studies, or both of the IL-10 signaling pathway. Medical records of IL-10/IL-10R-deficient patients were reviewed and compiled., Results: Of 40 patients, we identified 7 with novel mutations, predominantly in consanguineous families with more than 1 affected member. IL-10/IL-10R-deficient patients had intractable enterocolitis, perianal disease, and fistula formation. HSCT was carried out in 2 patients with IL-10 deficiency and 1 patient with IL-10R α chain deficiency and proved to be an effective therapy, leading to rapid improvement of clinical symptoms and quality of life., Conclusion: Because the defect in patients with IL-10/IL-10R deficiency resides in hematopoietic lineage cells and their colitis is resistant to standard immunosuppressive therapy, HSCT should be considered early as a potentially curative therapeutic option., (Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.)

Published
2013
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49. Is sildenafil citrate affect endometrial receptivity? An immunohistochemical study.

Author

Biyiksiz PC, Filiz S, and Vural B

Subjects
Animals, Biomarkers metabolism, Decidua cytology, Decidua drug effects, Decidua metabolism, Endometrium cytology, Epithelial Cells cytology, Epithelial Cells drug effects, Epithelial Cells metabolism, Female, Fertility Agents, Female pharmacology, Immunohistochemistry, Integrin beta3 metabolism, Placentation drug effects, Pregnancy, Purines pharmacology, Random Allocation, Rats, Rats, Wistar, Sildenafil Citrate, Stromal Cells cytology, Stromal Cells drug effects, Stromal Cells metabolism, Vascular Endothelial Growth Factors metabolism, Embryo Implantation drug effects, Endometrium drug effects, Endometrium metabolism, Ovulation Induction, Phosphodiesterase 5 Inhibitors pharmacology, Piperazines pharmacology, Sulfones pharmacology
Abstract

The authors aimed to investigate the effect of sildenafil citrate (Sc) on expressions of β(3) integrin and vascular endothelial growth factor (VEGF), which is taking part in endometrium receptivity in implantation window period in controlled ovarian hyperstimulation (COH) performed rats. In this study, Wistar albino female rats were used and were divided into four groups as control, COH, Sc, and COH + Sc groups. They were sacrificed on the third, fourth, and fifth day of pregnancy, uteruses were resected, and uteri sections were stained with immunohistochemical method and evaluated. β(3) integrin immunoreactivity was most intensely observed in the endometrial glandular epithelium (GE) and stromal cells in the Sc group on the third day, whereas immunoreactivity was most intensely detected in the luminal epithelium (LE), GE, and stromal cells in the Sc group on the fourth day. VEGF immunoreactivity was most intensely observed in the endometrial LE in the Sc group on the third day, in the Sc and COH + Sc groups on the fourth day, and in the COH + Sc group on the fifth day. Our results indicated that Sc plays a role in both implantation and decidualization by affecting β(3) integrin and VEGF expressions in implantation window period in rats.

Published
2011
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50. Note: Aligned deposition and modal characterization of micron and submicron poly(methyl methacyrlate) fiber cantilevers.

Author

Nain AS, Filiz S, Ozdoganlar OB, Sitti M, and Amon C

Subjects
Microscopy, Atomic Force methods, Microscopy, Electron, Scanning, Models, Theoretical, Motion, Temperature, Vibration, Nanotechnology methods, Polymethyl Methacrylate
Abstract

Polymeric micro-/nanofibers are finding increasing use as sensors for novel applications. Here, we demonstrate the ability to deposit an array of poly(methyl methacyrlate) fibers with micron and submicron diameters in aligned configurations on customized piezoelectric shakers. Using lateral motion of an atomic force microscope tip, fibers are broken to obtain fiber cantilevers of high aspect ratio (length/diameter > 20). The resonant frequencies of fabricated microfiber cantilevers are experimentally measured using a laser Doppler vibrometer. An average Young's modulus of 3.5 GPa and quality factor of 20 were estimated from the experimentally obtained frequency responses.

Published
2010
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