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9 results on '"Ferenc Gyenes"'

1. Convenient Access to Primary Amines by Employing the Barbier-Type Reaction of N-(Trimethylsilyl)imines Derived from Aromatic and Aliphatic Aldehydes

Author

John T. Welch, Kathryn E. Bergmann, and Ferenc Gyenes

Subjects
chemistry.chemical_classification, Aldimine, chemistry.chemical_compound, Primary (chemistry), chemistry, Trimethylsilyl, Organic Chemistry, Reactive intermediate, Combinatorial chemistry
Abstract

A new versatile preparation of primary amines via benzylation of aromatic and aliphatic aldimines is described. Sonochemical and traditional methods for generation of the reactive intermediates are compared and contrasted. Competitive reactions were analyzed via free energy relationships to support the proposed alkylative mechanism.

Published
1998

2. Pyrazinoic Acid Esters with Broad Spectrum in Vitro Antimycobacterial Activity

Author

John T. Welch, Livia B. Gregor, Michael H. Cynamon, Rayomand H. Gimi, Kathryn E. Bergmann, Cindy A. Sharpe, Radha Rapolu, Hye Jung Han, Gregorio Luciano, and Ferenc Gyenes

Subjects
Tuberculosis, medicine.drug_class, Microbial Sensitivity Tests, Antimycobacterial, Mycobacterium, Microbiology, Mycobacterium tuberculosis, Structure-Activity Relationship, chemistry.chemical_compound, Pyrazinoic acid, Drug Discovery, medicine, Antibacterial agent, Mycobacterium kansasii, biology, Chemistry, Esters, Pyrazinamide, bacterial infections and mycoses, biology.organism_classification, medicine.disease, Anti-Bacterial Agents, Molecular Medicine, medicine.drug
Abstract

A series of substituted pyrazinoic acid esters has been prepared and examined for their in vitro activity against Mycobacterium avium and Mycobacterium kansasii as well as Mycobacterium tuberculosis. Modification of both the pyrazine nucleus and the ester functionality have been very successful in expanding the activity of pyrazinamide to include M. avium and M. kansasii, organisms normally not susceptible to pyrazinamide. Several of these compounds have activities 100-1000-fold greater than that of pyrazinamide against M. tuberculosis.

Published
1995

3. ChemInform Abstract: Pyrazinoic Acid Esters with Broad Spectrum in vitro Antimycobacterial Activity

Author

Hye Jung Han, Michael H. Cynamon, Kathryn E. Bergmann, John T. Welch, Livia B. Gregor, Cindy A. Sharpe, Gregorio Luciano, Rayomand H. Gimi, Radha Rapolu, and Ferenc Gyenes

Subjects
Mycobacterium kansasii, Tuberculosis, biology, Chemistry, Stereochemistry, medicine.drug_class, General Medicine, Pyrazinamide, bacterial infections and mycoses, biology.organism_classification, Antimycobacterial, medicine.disease, In vitro, Microbiology, Mycobacterium tuberculosis, chemistry.chemical_compound, Pyrazinoic acid, medicine, Mycobacterium, medicine.drug
Abstract

A series of substituted pyrazinoic acid esters has been prepared and examined for their in vitro activity against Mycobacterium avium and Mycobacterium kansasii as well as Mycobacterium tuberculosis. Modification of both the pyrazine nucleus and the ester functionality have been very successful in expanding the activity of pyrazinamide to include M. avium and M. kansasii, organisms normally not susceptible to pyrazinamide. Several of these compounds have activities 100-1000-fold greater than that of pyrazinamide against M. tuberculosis.

Published
2010

4. ChemInform Abstract: Convenient Access to Primary Amines by Employing the Barbier-Type Reaction of N-(Trimethylsilyl)imines Derived from Aromatic and Aliphatic Aldehydes

Author

Ferenc Gyenes, John T. Welch, and Kathryn E. Bergmann

Subjects
chemistry.chemical_classification, Aldimine, chemistry.chemical_compound, Primary (chemistry), chemistry, Trimethylsilyl, Reactive intermediate, Organic chemistry, General Medicine
Abstract

A new versatile preparation of primary amines via benzylation of aromatic and aliphatic aldimines is described. Sonochemical and traditional methods for generation of the reactive intermediates are compared and contrasted. Competitive reactions were analyzed via free energy relationships to support the proposed alkylative mechanism.

Published
2010

9. Asymmetric Fluoroorganic Chemistry

Author

P. V. RAMACHANDRAN, Robert Filler, Herbert C. Brown, Katsuhiko Iseki, Robert V. Hoffman, Junhua Tao, Akihiro Ishii, Koichi Mikami, Vadim A. Soloshonok, Ahmed Abouabdellah, Jean-Pierre Bégué, Danièle Bonnet-Delpon, Andrei Kornilov, Isabelle Rodrigues, Truong Thi Thanh Nga, Pierfrancesco Bravo, Luca Bruché, Marcello Crucianelli, Fiorenza Viani, Matteo Zanda, M. Venkat Ram Reddy, Michael T. Rudd, Alessandro Volonterio, Takashi Yamazaki, Shuichi Hiraoka, Tomoya Kitazume, Iwao Ojima, Tadashi Inoue, John C. Slater, Songnian Lin, Scott D. Kuduk, Subrata Chakravarty, John J. Walsh, Thierry Cresteil, Bernard Monsarrat, Paula Pera, Ralph J. Bernacki, Ferenc Gyenes, John T. Welch, K. L. Kirk, B. Herbert, S.-F. Lu, B. Jayachandran, W. L. Padgett, O. Olufunke, J. W. Daly, G. Haufe, K. W. Laue, D. O'Hagan, D. B. Harper, Tamejiro Hiyama, Tetsuo Kusumoto, Hiroshi Matsutani, Maria Teresa Messina, Pierangelo Metrangolo, Giuseppe Resnati, Bruce C. Hamper, Kindrick L. Leschinsky, Deborah A. Mischke, S. Douglas Prosch, Keith Ramig, P. V. RAMACHANDRAN, Robert Filler, Herbert C. Brown, Katsuhiko Iseki, Robert V. Hoffman, Junhua Tao, Akihiro Ishii, Koichi Mikami, Vadim A. Soloshonok, Ahmed Abouabdellah, Jean-Pierre Bégué, Danièle Bonnet-Delpon, Andrei Kornilov, Isabelle Rodrigues, Truong Thi Thanh Nga, Pierfrancesco Bravo, Luca Bruché, Marcello Crucianelli, Fiorenza Viani, Matteo Zanda, M. Venkat Ram Reddy, Michael T. Rudd, Alessandro Volonterio, Takashi Yamazaki, Shuichi Hiraoka, Tomoya Kitazume, Iwao Ojima, Tadashi Inoue, John C. Slater, Songnian Lin, Scott D. Kuduk, Subrata Chakravarty, John J. Walsh, Thierry Cresteil, Bernard Monsarrat, Paula Pera, Ralph J. Bernacki, Ferenc Gyenes, John T. Welch, K. L. Kirk, B. Herbert, S.-F. Lu, B. Jayachandran, W. L. Padgett, O. Olufunke, J. W. Daly, G. Haufe, K. W. Laue, D. O'Hagan, D. B. Harper, Tamejiro Hiyama, Tetsuo Kusumoto, Hiroshi Matsutani, Maria Teresa Messina, Pierangelo Metrangolo, Giuseppe Resnati, Bruce C. Hamper, Kindrick L. Leschinsky, Deborah A. Mischke, S. Douglas Prosch, and Keith Ramig

Published
1999

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