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Pyrazinoic Acid Esters with Broad Spectrum in Vitro Antimycobacterial Activity
- Source :
- Journal of Medicinal Chemistry. 38:3902-3907
- Publication Year :
- 1995
- Publisher :
- American Chemical Society (ACS), 1995.
-
Abstract
- A series of substituted pyrazinoic acid esters has been prepared and examined for their in vitro activity against Mycobacterium avium and Mycobacterium kansasii as well as Mycobacterium tuberculosis. Modification of both the pyrazine nucleus and the ester functionality have been very successful in expanding the activity of pyrazinamide to include M. avium and M. kansasii, organisms normally not susceptible to pyrazinamide. Several of these compounds have activities 100-1000-fold greater than that of pyrazinamide against M. tuberculosis.
- Subjects :
- Tuberculosis
medicine.drug_class
Microbial Sensitivity Tests
Antimycobacterial
Mycobacterium
Microbiology
Mycobacterium tuberculosis
Structure-Activity Relationship
chemistry.chemical_compound
Pyrazinoic acid
Drug Discovery
medicine
Antibacterial agent
Mycobacterium kansasii
biology
Chemistry
Esters
Pyrazinamide
bacterial infections and mycoses
biology.organism_classification
medicine.disease
Anti-Bacterial Agents
Molecular Medicine
medicine.drug
Subjects
Details
- ISSN :
- 15204804 and 00222623
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....24eac85c4c6ef44980ee28a655cbd7b9