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33 results on '"Fenske, Martina"'

1. Exploring BPA alternatives – Environmental levels and toxicity review

Author

Adamovsky, Ondrej, Groh, Ksenia J., Białk-Bielińska, Anna, Escher, Beate I., Beaudouin, R., Mora Lagares, Liadys, Tollefsen, Knut Erik, Fenske, Martina, Mulkiewicz, Ewa, Creusot, Nicolas, Sosnowska, Anita, Loureiro, Susana, Beyer, Jonny, Repetto, Guillermo, Štern, Alja, Lopes, Isabel, Monteiro, Marta, Zikova-Kloas, Andrea, Eleršek, Tina, Vračko, Marjan, Zdybel, Szymon, Puzyn, Tomasz, Koczur, Weronika, Ebsen Morthorst, Jane, Holbech, Henrik, Carlsson, Gunnar, Örn, Stefan, Herrero, Óscar, Siddique, Ayesha, Liess, Matthias, Braun, Georg, Srebny, Vanessa, Žegura, Bojana, Hinfray, Nathalie, Brion, François, Knapen, Dries, Vandeputte, Ellen, Stinckens, Evelyn, Vergauwen, Lucia, Behrendt, Lars, João Silva, Maria, Blaha, Ludek, and Kyriakopoulou, Katerina

Published
2024
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4. Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

Author

Moraes, Carolina B., Witt, Gesa, Kuzikov, Maria, Ellinger, Bernhard, Calogeropoulou, Theodora, Prousis, Kyriakos C., Mangani, Stefano, Di Pisa, Flavio, Landi, Giacomo, Iacono, Lucia Dello, Pozzi, Cecilia, Freitas-Junior, Lucio H., dos Santos Pascoalino, Bruno, Bertolacini, Claudia P., Behrens, Birte, Keminer, Oliver, Leu, Jennifer, Wolf, Markus, Reinshagen, Jeanette, Cordeiro-da-Silva, Anabela, Santarem, Nuno, Venturelli, Alberto, Wrigley, Stephen, Karunakaran, Deepa, Kebede, Bethlehem, Pöhner, Ina, Müller, Wolfgang, Panecka-Hofman, Joanna, Wade, Rebecca C., Fenske, Martina, Clos, Joachim, Alunda, José María, Corral, María Jesús, Uliassi, Elisa, Bolognesi, Maria Laura, Linciano, Pasquale, Quotadamo, Antonio, Ferrari, Stefania, Santucci, Matteo, Borsari, Chiara, Costi, Maria Paola, and Gul, Sheraz

Published
2019
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22. Corrigendum to 'Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test'

Author

Muth-Köhne, Elke, Westphal-Settele, Kathi, Brückner, Jasmin, Konradi, Sabine, Schiller, Viktoria, Baumann, Lisa, Schäfers, Christoph, Teigeler, Matthias, Fenske, Martina, and Publica

Subjects
qPCR, Fadrozole, Fish sexual development test (FSDT), Adverse outcome pathway (AOP), Aromatase inhibition, Zebrafish
Abstract

The Fish Sexual Development Test (FSDT) is a non-reproductive test to assess adverse effects of endocrine disrupting chemicals. With the present study it was intended to evaluate whether gene expression end-points would serve as predictive markers of endocrine disruption in a FSDT. For proof-of-concept, a FSDTaccording to the OECD TG 234 was conducted with the non-steroidal aromatase inhibitor fadrozole (testconcentrations: 10µg/L, 32 µg/L, 100 µg/L) using zebrafish (Danio rerio). Gene expression analyses using quantitative RT-PCR were included at 48 h, 96 h, 28 days and 63 days post fertilization (hpf, dpf). The selection of genes aimed at finding molecular endpoints which could be directly linked to the adverse apical effects of aromatase inhibition. The most prominent effects of fadrozole exposure on the sexual development of zebrafish were a complete sex ratio shift towards males and an acceleration of gonad maturation already at low fadrozole concentrations (10 µg/L). Due to the specific inhibition of the aromatase enzyme (Cyp19) by fadrozole and thus, the conversion of C19-androgens to C18-estrogens, the steroid hormone balance controlling the sex ratio of zebrafish was altered. The resulting key event is the regulation of directly estrogen-responsive genes. Subsequently, gene expression of vitellogenin 1 (vtg1)and of the aromatase cyp19a1b isoform (cyp19a1b), were down-regulated upon fadrozole treatment compared to controls. For example, mRNA levels of vtg1 were down-regulated compared to the controls as early as 48 hpf and 96 hpf. Further regulated genes cumulated in pathways suggested to be controlled by endocrine mechanisms, like the steroid and terpenoid synthesis pathway (e.g. mevalonate (diphospho)decarboxylase (mvd), lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase; lss), methylsterol monooxy-genase 1 (sc4mol)) and in lipid transport/metabolic processes (steroidogenic acute regulatory protein (star),apolipoprotein Eb (apoEb)). Taken together, this study demonstrated that the existing Adverse Outcome Pathway (AOP) for aromatase inhibition in fish can be translated to the life-stage of sexual differentiation. We were further able to identify MoA-specific marker gene expression which can be instrumentalin defining new measurable key events (KE) of existing or new AOPs related to endocrine disruption.

Published
2016

23. Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos

Author

Hausen, Jonas, primary, Otte, Jens C., additional, Legradi, Jessica, additional, Yang, Lixin, additional, Strähle, Uwe, additional, Fenske, Martina, additional, Hecker, Markus, additional, Tang, Song, additional, Hammers-Wirtz, Monika, additional, Hollert, Henner, additional, Keiter, Steffen H., additional, and Ottermanns, Richard, additional

Published
2017
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24. Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17β-trenbolone

Author

Baumann, Lisa, Knörr, Susanne, Keiter, Susanne, Nagel, Tina, Rehberger, Kristina, Volz, Sina, Oberrauch, Sophia, Schiller, Viktoria, Fenske, Martina, Holbech, Henrik, Segner, Helmut, and Braunbeck, Thomas

Subjects
animal structures
Abstract

The aim of the present study was to investigate the effects of the androgenic endocrine disruptor 17β-trenbolone on the sexual development of zebrafish (Danio rerio) with special emphasis on the question whether adverse outcomes of developmental exposure are reversible or persistent. An exposure scenario including a recovery phase was chosen to assess the potential reversibility of androgenic effects. Zebrafish were exposed to environmentally relevant concentrations of 17β-trenbolone (1 - 30 ng/L) from fertilization until completion of gonad sexual differentiation (60 days post-hatch, dph). Thereafter, exposure was either followed by 40 d of recovery in clean water or continued until 100 dph, the age when zebrafish start being able to reproduce. Fish exposed for 100 d to 10 or 30 ng/L 17β-trenbolone were masculinized at different biological effect levels, as evidenced from a concentration-dependent shift of the sex ratio towards males, as well as a significantly increased maturity of testes. Gonad morphological masculinization occurred in parallel with decreased vitellogenin concentrations in both sexes. Changes of brain aromatase (cyp19b) mRNA expression showed no consistent trend, neither with respect to exposure duration nor to concentration. Gonad morphological masculinization as well as the decrease of vitellogenin persisted after depuration over 40 d in clean water. This lack of recovery suggests that androgenic effects on sexual development of zebrafish are irreversible.

Published
2014
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25. Corrigendum to “Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test” [Aquat. Toxicol. 176 (2016) 116–127]

Author

Muth-Köhne, Elke, primary, Westphal-Settele, Kathi, additional, Brückner, Jasmin, additional, Konradi, Sabine, additional, Schiller, Viktoria, additional, Baumann, Lisa, additional, Schäfers, Christoph, additional, Teigeler, Matthias, additional, and Fenske, Martina, additional

Published
2016
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26. Fishing for contaminants: identification of three mechanism specific transcriptome signatures using <italic>Danio rerio</italic> embryos.

Author

Hausen, Jonas, Otte, Jens C., Legradi, Jessica, Yang, Lixin, Strähle, Uwe, Fenske, Martina, Hecker, Markus, Tang, Song, Hammers-Wirtz, Monika, Hollert, Henner, Keiter, Steffen H., and Ottermanns, Richard

Subjects
ZEBRA danio, EMBRYOS, BRACHYDANIO, EMBRYOLOGY, NEUROTOXICOLOGY
Abstract

In ecotoxicology, transcriptomics is an effective way to detect gene expression changes in response to environmental pollutants. Such changes can be used to identify contaminants or contaminant classes and can be applied as early warning signals for pollution. To do so, it is important to distinguish contaminant-specific transcriptomic changes from genetic alterations due to general stress. Here we present a first step in the identification of contaminant class-specific transcriptome signatures. Embryos of zebrafish (Danio rerio) were exposed to three substances (methylmercury, chlorpyrifos and Aroclor 1254, each from 24 to 48 hpf exposed) representing sediment typical contaminant classes. We analyzed the altered transcriptome to detect discriminative genes significantly regulated in reaction to the three applied contaminants. By comparison of the results of the three contaminants, we identified transcriptome signatures and biologically important pathways (using Cytoscape/ClueGO software) that react significantly to the contaminant classes. This approach increases the chance of finding genes that play an important role in contaminant class-specific pathways rather than more general processes. [ABSTRACT FROM AUTHOR]

Published
2018
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28. Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17β‐trenbolone

Author

Baumann, Lisa, primary, Knörr, Susanne, additional, Keiter, Susanne, additional, Nagel, Tina, additional, Rehberger, Kristina, additional, Volz, Sina, additional, Oberrauch, Sophia, additional, Schiller, Viktoria, additional, Fenske, Martina, additional, Holbech, Henrik, additional, Segner, Helmut, additional, and Braunbeck, Thomas, additional

Published
2014
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