Search

Your search keyword '"Fayad Raja"' showing total 213 results
Start Over Author "Fayad Raja"
213 results on '"Fayad Raja"'

1. Effect of exercise on chemically-induced colitis in adiponectin deficient mice

Author

Saxena Arpit, Fletcher Emma, Larsen Bianca, Baliga Manjeshwar, Durstine J, and Fayad Raja

Subjects
Adipokines, Cytokines, Inflammation, Epithelial cell proliferation, Intestine, Therapeutics. Pharmacology, RM1-950
Abstract

Abstract Background Inflammatory bowel diseases are associated with increased adiponectin (APN) levels, which may exert pro-inflammatory effects in these individuals. Since habitual exercise may increase APN, the aim of this study was to determine how exercise training affects mice with acute colitis. Methods Male adiponectin knock out (APNKO) and wild type (WT) mice (C57BL/6) were randomly assigned to 4 different groups: 1) Sedentary (SED); 2) Exercise trained (ET); 3) Sedentary with dextran sodium sulfate (DSS) treatment (SED + DSS); and 4) Exercise trained with DSS (ET + DSS). Exercise-trained mice ran at 18 m/min for 60 min, 5d/wk for 4 weeks. Subsequently, the ET + DSS and the SED + DSS mice received 2% DSS in their drinking water for 5 days (d), followed by 5d of regular water. Results The clinical symptoms of acute colitis (diarrhea, stool haemoccult, and weight loss) were unaffected by exercise and there was no difference between the APNKO and WT mice (p > 0.05) except on day 39. However, the clinical symptoms of the DSS-treated APNKO mice were worse than WT mice treated with DSS and had increased susceptibility to intestinal inflammation due to increased local STAT3 activation, higher IL-6, TNF-α, IL-1β and IL-10 levels, and as a result had increased intestinal epithelial cell proliferation (p Conclusions Exercise training may contribute in alleviating the symptoms of acute colitis and APN deficiency may exacerbate the intestinal inflammation in DSS-induced colitis.

Published
2012
Full Text
View/download PDF

3. List of Contributors

Author

Abbasnezhad, Amir, primary, Acosta, Andrés, additional, Arunima, Aryashree, additional, Azagra-Boronat, Ignasi, additional, Baliga, Manjeshwar Shrinath, additional, Bayir, Ayse Gunes, additional, Bernhardt, Cassandra, additional, Bhagatwala, Jigar, additional, Biswas, Debabrata, additional, Calderón, Gerardo, additional, Camps-Bossacoma, Mariona, additional, Carrion, Michael, additional, Castell, Margarida, additional, Choghakhori, Razieh, additional, Coppola, Vincenzo, additional, Das, Jugal Kishore, additional, Day, Andrew S., additional, DemirkesenBiçak, Hilal, additional, Doğan, Murat, additional, Fayad, Raja, additional, Ferreira, Adaliene Versiani Matos, additional, Fiagbor, Rita, additional, George, Thomas, additional, Gyawali, Rabin, additional, Hekmatdoost, Azita, additional, Hutson, J.M., additional, Ibrahim, Salam A., additional, Issa, Aseel T., additional, Kalekhan, Faizan, additional, Kaur, Kamaljit, additional, Kearsey, I., additional, Kiziltan, Huriye Senay, additional, Kocyigit, Abdurrahim, additional, Kuda, Takashi, additional, Lei, Shaohua, additional, Massot-Cladera, Malen, additional, McRorie, Johnson W., additional, Mokhtari, Zeinab, additional, Nagarajan, Vinod, additional, Newman, Robert H., additional, Nwamaioha, Nwadiuto, additional, Patel, Puja, additional, Peng, Mengfei, additional, Pérez-Cano, Francisco J., additional, Rao, Suresh, additional, Rodríguez-Lagunas, Maria José, additional, Saldanha, Elroy, additional, Saxena, Arpit, additional, Scarpato, Elena, additional, Sharma, Amol, additional, Shomali, T., additional, Silveira, Ana Letícia Malheiros, additional, Southwell, B.R., additional, Staiano, Annamaria, additional, Suar, Mrutyunjay, additional, Tahergorabi, Reza, additional, Teixeira, Mauro Martins, additional, Tekiner, İsmail Hakkı, additional, Venkatesh, Ponemone, additional, Yari, Zahra, additional, Yik, Y.I., additional, Yuan, Lijuan, additional, Zhong, Wei, additional, Zhou, Zhanxiang, additional, and Zimmerman, Tahl, additional

Published
2019
Full Text
View/download PDF

15. Resveratrol improves muscle function but not oxidative capacity in young mdx mice

Author

Gordon, Bradley S., Delgado-Diaz, Diana C., Carson, James, Fayad, Raja, Wilson, L. Britt, and Kostek, Matthew C.

Subjects
Muscular dystrophy -- Physiological aspects, Oxidative stress -- Physiological aspects, Resveratrol -- Health aspects, Biological sciences
Abstract

Patients with Duchenne muscular dystrophy (DMD) have reduced muscle function due to chronic muscle damage, inflammation, oxidative stress, and reduced oxidative capacity. Resveratrol reduces inflammation and oxidative stress, and increases oxidative capacity in other disease models. The purpose of this study was to determine the effects of resveratrol on muscle function, muscle pathology, and oxidative capacity in young mdx mice. For this, 4- to 5-week-old male mdx mice were randomized into control or resveratrol-treated groups and given resveratrol (100 mg/kg body mass) or an equal volume of water by gavage every other day for 8 weeks. Muscle function was assessed pre- and post-treatment. Central nucleation, total immune cell infiltrate, oxidative stress, and oxidative capacity were measured post-treatment. Resveratrol mediated substantial improvements in rotarod performance and in-situ peak tension by 53% and 17%, respectively, and slight improvements in central nucleation and oxidative stress. Resveratrol did not affect total immune cell infiltrate at 12 weeks of age, and had no effect on oxidative capacity. Resveratrol improves muscle function in mdx mice despite small changes in muscle pathology. The likely mechanism is a resveratrol-mediated reduction in immune cell infiltrate at the early stages of this disease, as previously reported by our laboratory. Key words: Duchenne muscular dystrophy, resveratrol, inflammation, oxidative stress, oxidative capacity, muscle damage, utrophin. Les patients atteints de la dystrophie musculaire de Duchesne (DMD) presentent une fonction musculaire reduite a cause d'un dommage musculaire chronique, d'une inflammation, d'un stress oxydant et d'une capacite oxydante reduite. Le resveratrol reduit l'inflammation et le stress oxydant, et il accroit la capacite oxydante dans d'autres modeles de maladies. Le but de cette etude etait d'evaluer les effets d'un traitement au resveratrol sur la fonction musculaire, la pathologie du muscle et la capacite oxydante de jeunes souris mdx. Des souris males mdx de 4-5 semaines ont ete reparties aleatoirement en groupes controles ou traites au resveratrol, et elles ont re^u le resveratrol (100 mg/kg) ou de l'eau a tous les deux jours pendant 8 semaines. La fonction musculaire a ete evaluee avant et apres le traitement. La nucleation centrale, l'infiltrat immunitaire total, le stress oxydant et la capacite oxydante ont ete mesures apres le traitement. Le resveratrol permettait d'obtenir des ameliorations substantielles de la performance au Rotarod et du pic de la tension in situ de 53% et 17%, respectivement, et une legere amelioration sur le plan de la nucleation centrale et du stress oxydant. Le resveratrol n'affectait pas l'infiltrat immunitaire total a l'age de 12 semaines et n'avait pas d'effet sur la capacite oxydante. Le resveratrol ameliore la fonction musculaire des souris mdx malgre de faibles changements sur le plan de la pathologie du muscle. Le mecanisme probable consiste en une reduction de l'infiltrat immunitaire dependante du resveratrol a des etapes precoces de cette maladie, comme rapporte precedemment par notre laboratoire. [Traduit par la Redaction] Mots-cles: dystrophie musculaire de Duchesne, resveratrol, inflammation, stress oxydant, capacite oxydante, dommage musculaire, utrophine., Introduction Duchenne muscular dystrophy (DMD) is the most common lethal genetic disease, affecting 1 in 3500 live male births (Hoffman et al. 1987). This disease is caused by mutations in [...]

Published
2014
Full Text
View/download PDF

20. List of Contributors

Author

Aramendi, Claudia, primary, Baliga, Manjeshwar Shrinath, additional, Bayir, Aysegül, additional, Bernabei, Roberto, additional, Bernstein, Adam, additional, Bhat, Harshith P., additional, Boloor, Rekha, additional, Bravo, Esther, additional, Calvani, Riccardo, additional, Candow, Darren G., additional, Carlsson, Eva, additional, Castonguay, Thomas W., additional, Chacko, Jacob, additional, Cheng, Wen-Hsing, additional, Chow, Clara K., additional, Colin, Marshall David, additional, Collamati, Agnese, additional, de Keizer, Laura, additional, Delattre, Ana Márcia, additional, Doley, Jennifer, additional, D’Silva, Prajnya, additional, El-Kadiki, Alia, additional, Ernst, Jana Barbara, additional, Fayad, Raja, additional, Fazal, Farhan, additional, Ferraz, Anete Curte, additional, Ferreira, Maria Pontes, additional, Ferreira-Filho, Sebastião Rodrigues, additional, Forbes, Scott C., additional, Francis, Athul, additional, Gendron, Fidji, additional, Gupta, Sanjay, additional, Hägg, Mary, additional, Haniadka, Raghavendra, additional, Head, Elizabeth, additional, Hosseini, Saeed, additional, Izagirre, Maite, additional, Jakribettu, Ramakrishna Pai, additional, Jayachander, Dipika, additional, Jia, Xiaofang, additional, Kalekhan, Faizan, additional, Kamath, Kratika, additional, Kaur, Kamaljeet, additional, Kitamori, Kazuya, additional, Krol, Wojciech, additional, Kumar, Ashish, additional, Landi, Francesco, additional, Latheef, Latheesh, additional, Maggini, Silvia, additional, Mane, Prajwal Prabhudev, additional, Marx, Tennille, additional, Marzetti, Emanuele, additional, Mathai, Rashmi Teresa, additional, McKenna, Elder Betty, additional, McLeod, Katherine, additional, Meera, Sharake, additional, Mostafavi, Seyed-Ali, additional, Naito, Hisao, additional, Nakajima, Tamie, additional, Nallemgera, Jozy Timothy, additional, Ntaios, George, additional, Pais, Saira, additional, Palatty, Princy Louis, additional, Palmer, Jaclyn, additional, Ponemone, Venkatesh, additional, Prabhu, Haladi Sudhir, additional, Rai, Manoj P., additional, Rai, Prajwith, additional, Rao, Sahana, additional, Ravi, Rithin, additional, Reddy, C.Damodar, additional, Robine, Juli, additional, Saldanha, Elroy, additional, Saxena, Arpit, additional, Serafini, Elisabetta, additional, Shivashankara, Arnadi Ramachandrayya, additional, Simon, Paul, additional, Sowmya, V., additional, Srivastava, Janmejai K., additional, Staziaki, Pedro Vinícius, additional, Sullivan, Patrick G., additional, Szliszka, Ewelina, additional, Thilakchand, Karadka Ramdas, additional, Tonse, Raees, additional, Vangavaragu, Jhansi Rani, additional, Vega de Céniga, Melina, additional, Venkatesh, Sunitha, additional, Vissavajjhala, Prabhakar, additional, Wintergerst, Eva Sabine, additional, Wishart, Karl, additional, Wu, Ryan T.Y., additional, Yetti, Husna, additional, Yonutas, Heather M., additional, Zhao, Changhui, additional, and Zittermann, Armin, additional

Published
2015
Full Text
View/download PDF

23. Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice

Author

Pini, Maria, Gove, Melissa E., Fayad, Raja, Cabay, Robert J., and Fantuzzi, Giamila

Subjects
Colitis -- Development and progression, Fat cells -- Properties, Colon (Anatomy) -- Properties, Cytokines -- Properties, Cell physiology -- Research, Biological sciences
Abstract

The goal of this study was to investigate the role of the adipokine adiponectin (APN) in development of spontaneous colitis in IL-10 knockout (KO) mice. To this aim, we generated double IL-10 APN KO mice and compared their disease development to that of single IL-10 KO mice. Both IL-10 KO and double IL-10 APN KO mice spontaneously developed colitis of comparable severity. No significant differences in inflammatory infiltrate or crypt elongation were observed in colonic tissue obtained from IL-10 KO and double IL-10 APN KO mice at either 12 or 20 wk of age. A comparable increase in circulating levels of serum amyloid A and IFN-[gamma] was observed in IL-10 KO and double IL-10 APN KO mice as disease progressed. In vitro stimulation of lymphocytes from mesenteric lymph nodes with anti-CD3 and anti-CD28 induced a significantly higher production of IL-17 and TNF-[alpha] in IL-10 KO and double IL-10 APN KO mice compared with their healthy litterrnates. No significant differences in cytokine production from lymphocytes or colonic mRNA expression of cytokines were observed between IL-10 KO and double IL-10 APN KO mice. Both IL-10 KO and double IL-10 APN KO mice had a similar decrease in body weight and bone mass compared with their respective healthy littermates. Finally, APN deficiency did not lead to development of insulin resistance, either in APN KO or double IL-10 APN K0 mice. In conclusion, lack of APN does not play a significant role in the pathogenesis of spontaneous colonic inflammation in the IL-10 KO model. adipocytes; colon; cytokines; inflammation

Published
2009

26. List of Contributors

Author

Aguiar, Odair, primary, Alkholy, Sarah Omar, additional, Allgrove, Judith, additional, Alqahtani, Samiah Naji, additional, Amini, Anna, additional, de Mello Andrade, Juliana Maria, additional, Andres-Lacueva, Cristina, additional, Aquilato, Andrea, additional, Arora, Rajesh, additional, Arranz, Sara, additional, Ashida, Hitoshi, additional, Avena, Paola, additional, Badole, Sachin L., additional, Baer-Dubowska, Wanda, additional, Bahrim, Gabriela, additional, Baliga, Manjeshwar Shrinath, additional, Barnes, Stephen, additional, Batista, Maria T., additional, Berhanu, Workalemahu Mikre, additional, Bhatia, Alka, additional, Bodhankar, Subhash L., additional, Bodnar, Lubomir, additional, Bolca, Selin, additional, Boto-Ordoñez, Maria, additional, Brizuela, Leyre, additional, Calhau, Conceição, additional, Carluccio, Maria Annunziata, additional, Carrasco-Pozo, Catalina, additional, Caruso, Anna, additional, Casaburi, Ivan, additional, Castro, Gerardo D., additional, Castro, José A., additional, Celep, Gulcin Sagdicoglu, additional, Chacko, Amala, additional, Chaudhari, Swapnil M., additional, Chen, Chung-Hwan, additional, Chen, Lixia, additional, Chiva-Blanch, Gemma, additional, Christensen, Kathrine Bisgaard, additional, Christensen, Lars Porskjær, additional, Chyu, Ming-Chien, additional, Cordova, Felina M., additional, Corona, Giulia, additional, Costa, G., additional, Cress, Brady F., additional, Crozier, Stephen J., additional, Cruz, M.T., additional, Cuvillier, Olivier, additional, Čvorović, Jovana, additional, Cyr, Lisa Danielle, additional, Czank, Charles, additional, D’Archivio, Massimo, additional, Davison, Glen, additional, De Caterina, Raffaele, additional, Deng, Guifang, additional, Devkar, Ranjitsinh V., additional, Doo, Taisha, additional, Doonan, Barbara, additional, Emami, Seyed Ahmad, additional, Estruch, Ramón, additional, Virgili, Fabio, additional, Falk, Michael, additional, Faria, Ana, additional, Farina, Grazia, additional, Fasolo, Daniel, additional, Fayad, Raja, additional, Ferreira, Maria Pontes, additional, Ferri, Claudio, additional, Forester, Sarah C., additional, Fornasaro, Stefano, additional, Cimino, Francesco, additional, Francis, Atul, additional, Francisco, V., additional, Fukuda, Itsuko, additional, Garcia-Aloy, Mar, additional, García-Mediavilla, María Victoria, additional, Gendron, Fidji, additional, Ghantasala, S., additional, Gil-Becerra, David, additional, Giovannini, Claudio, additional, Givigliano, Francesco, additional, Goldstein, Mark R., additional, Goel, Ajay, additional, Gollücke, Andréa Pittelli Boiago, additional, González-Gallego, Javier, additional, Govindaraghavan, Suresh, additional, Grassi, Davide, additional, Gunawardena, Dhanushka, additional, Guo, Honghui, additional, Habauzit, Véronique, additional, Haegeman, Guy, additional, He, Xiran, additional, Hegde, Mahabaleshwar V., additional, Heyninck, Karen, additional, Hsieh, Tze-chen, additional, Hurst, W. Jeffrey, additional, Iemma, Francesca, additional, Igoe, Ann, additional, Iglesias, Jacobo, additional, Ikeda, Ikuo, additional, Jadeja, Ravirajsinh N., additional, Jaffe, Russell, additional, Janda, Elzbieta, additional, Janel, Nathalie, additional, Jangam, Ganesh B., additional, Jayachander, Dipika, additional, Jiang, Fan, additional, Jirillo, Emilio, additional, Joo, Eun Ji, additional, Joseph, Nadhini, additional, Aguiar, Odair, additional, Juturu, Vijaya, additional, Kalekhan, Faizan, additional, Kamath, Krithika, additional, Karana, Rita, additional, Kaur, Kamaljeet, additional, Keating, Elisa, additional, Kennedy, David O., additional, Kerr, Jason, additional, Khaled, Mohd, additional, Khoo, Christina, additional, Khymenets, Olha, additional, Kim, Jiyoung, additional, Kobayashi, Makoto, additional, Kobori, Masuko, additional, Kochikuzhyil, Benson Mathai, additional, Koffas, Mattheos A.G., additional, Korniluk, Jan, additional, Kumar, Ashish, additional, Kumar, G., additional, Kumar, Yashwant, additional, Kumazawa, Yosho, additional, Kurien, Biji T., additional, Kwun, In-Sook, additional, Lambert, Joshua D., additional, Lamuela-Raventos, Rosa Maria, additional, Latheef, Latheesh, additional, Lee, Hyong Joo, additional, Lee, Ki Won, additional, Li, Huabin, additional, Li, Sha, additional, Llorach, Rafael, additional, Lopez, Victoria, additional, Maciel, María E., additional, Magrone, Thea, additional, Mani, Jayashree, additional, Marotta, Francesco, additional, Marquardt, Kristen Conrad, additional, Martel, Fátima, additional, Martínez, Verónica, additional, Maru, Girish B., additional, Mascitelli, Luca, additional, Masella, Roberta, additional, Maskarinec, Gertraud, additional, Massaro, Marika, additional, Masunov, Artëm E., additional, Mathew, Geetha, additional, Medina, Isabel, additional, Medina-Remón, Alexander, additional, Menaa, Abder, additional, Menaa, Bouzid, additional, Menaa, Farid, additional, Miglio, C., additional, Milenkovic, Dragan, additional, Mitjans, Montserrat, additional, Miura, Tomisato, additional, Mo, Huanbiao, additional, Mollace, Vincenzo, additional, Morand, Christine, additional, Moribito, G., additional, Mudgal, Piya Paul, additional, Münch, Gerald, additional, Murakami, Akira, additional, Nagasako-Akazome, Yoko, additional, Nayak, Yogendra, additional, Neves, B.M., additional, Noll, Christophe, additional, Nowak, Renata, additional, Nowacka, Natalia, additional, Odendaal, Antoinette Y., additional, Olech, Marta, additional, Ong, Khang Wei, additional, Osakabe, Naomi, additional, Paluszczak, Jarosław, additional, Parisi, Ortensia Ilaria, additional, Passamonti, Sabina, additional, Patil, Kalyani Y., additional, Pazos, Manuel, additional, Peluso, I., additional, Petry, Nicolai, additional, Pezzi, Vincenzo, additional, Piantanida, Marta, additional, Picci, Nevio, additional, Pimple, Bhushan P., additional, Pinto, John Thomas, additional, Pires, Vanessa Cardoso, additional, Prasain, Jeevan K., additional, Pravettoni, Valerio, additional, Primavesi, Laura, additional, Puoci, Francesco, additional, Quintans, Leandro N., additional, Rabassa, Montse, additional, Rai, Prajwith, additional, Rajeev, Antappa Govindaraju, additional, Rao, Suresh, additional, Rapeanu, Gabriela, additional, Rastmanesh, Reza, additional, Ravi, Rithin, additional, Restuccia, Donatella, additional, Ribeiro, Daniel Araki, additional, Rodrigo, Ramón, additional, Rotches-Ribalta, Maria, additional, Rouhani, Mae Nicole, additional, Saldanha, Elroy, additional, Saija, Antonella, additional, Sánchez-Campos, Sonia, additional, Saxena, Arpit, additional, Scazzocchio, Beatrice, additional, Schauss, Alexander G., additional, Scoditti, Egeria, additional, Scofield, R. Hal, additional, Serafini, Mauro, additional, Sharma, Rakesh, additional, Shen, Chwan-Li, additional, Shende, Pankaj S., additional, Shetty, Vaishaka, additional, Shivashankara, Arnadi Ramachandrayya, additional, Shoji, Toshihiko, additional, Simon, Paul, additional, Sinicropi, Maria Stefania, additional, Smith, Brenda J, additional, Sony, Dargi, additional, Speciale, Antonio, additional, Spencer, Jeremy P.E., additional, Stalmach, Angélique, additional, Stanciuc, Nicoleta, additional, Stover, Mitchel G, additional, Synowiec, Agnieszka, additional, Szarlej-Wcislo, Katarzyna, additional, Tajpara, P., additional, Tan, Benny Kwong Huat, additional, Tao, Ling, additional, Tayarani-Najaran, Nilufar, additional, Tayarani-Najaran, Zahra, additional, Thilakchand, Karadka Ramdas, additional, Tomás-Barberán, Francisco A., additional, Tomás-Navarro, María, additional, Tramer, Federica, additional, Tresserra-Rimbau, Anna, additional, Tréton, Jacques, additional, Tulipani, Sara, additional, Tuñón, María J., additional, Unnikrishnan, Mazhuvancherry K., additional, Urpi-Sarda, Mireia, additional, Valderas-Martínez, Palmira, additional, Vallejo, Fernando, additional, Vauzour, David, additional, Vázquez-Fresno, Rosa, additional, Venkatesh, Ponemone, additional, Veerapur, Veeresh, additional, Vinardell, M. Pilar, additional, Walker, Ross, additional, Watson, Ronald R., additional, Wcislo, Gabriel, additional, Wightman, Emma L., additional, Wilkins, John, additional, Wu, Erxi, additional, Wu, Joseph M, additional, Wu, Shan, additional, Xia, Enqin, additional, Xia, Min, additional, Yajima, Hiroaki, additional, Zanwar, Anand A., additional, and Ziberna, Lovro, additional

Published
2014
Full Text
View/download PDF

37. Antibiotic-mediated bacteriome depletion in Apc Min/+mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression

Author

Kaur, Kamaljeet, primary, Saxena, Arpit, additional, Debnath, Irina, additional, O'Brien, Jacqueline L., additional, Ajami, Nadim J., additional, Auchtung, Thomas A., additional, Petrosino, Joseph F., additional, Sougiannis, Alexander-Jacques, additional, Depaep, Sarah, additional, Chumanevich, Alexander, additional, Gummadidala, Phani M., additional, Omebeyinje, Mayomi H., additional, Banerjee, Sourav, additional, Chatzistamou, Ioulia, additional, Chakraborty, Paramita, additional, Fayad, Raja, additional, Berger, Franklin G., additional, Carson, James A., additional, and Chanda, Anindya, additional

Published
2018
Full Text
View/download PDF

42. Negative Effects of Time in Bed Extension: A Pilot Study

Author

Reynold, Alexandria M., Bowles, Emily R., Saxena, Arpit, Fayad, Raja, and Youngstedt, Shawn D.

Subjects
Article
Abstract

Epidemiologic studies have consistently shown an association of long sleep (≥8 hr) with mortality and multiple morbidities. However, there has been little experimental investigation of the effects of sleep extension. The aim of this study was to examine the effects of time in bed (TIB) extension, on depression, anxiety, sleepiness, and systemic inflammation. Following baseline, 14 healthy sleepers (31.79±10.94 years) were randomized to one of two one-week treatments: (1) a TIB extension treatment involving a fixed sleep schedule in which TIB was increased by 3 hours/night compared with the participants' median baseline TIB; (2) a control treatment involving a fixed schedule in which TIB was the same as the participants' median baseline TIB. Actigraphic recording of sleep was assessed throughout both weeks. Self-reported depression, state anxiety, sleepiness, and sleep quality, as well as blood pressure, and inflammation were assessed at baseline and following the treatment week. Compared with baseline, TIB increased by 127.12±3.92 min and total sleep time increased by 119.88±18.52 min during TIB extension, but decreased slightly in the control treatment. Depression was elevated more following TIB extension (effect size (

Published
2014

44. Fluoroquinolone-related neuropsychiatric and mitochondrial toxicity: a collaborative investigation by scientists and members of a social network

Author

Kaur, Kamaljeet, primary, Fayad, Raja, additional, Saxena, Arpit, additional, Frizzell, Norma, additional, Chanda, Anindya, additional, Das, Suvarthi, additional, Chatterjee, Saurabh, additional, Hegde, Shweta, additional, Baliga, Manjeshwar, additional, Ponemone, Venkatesh, additional, Rorro, Matthew, additional, Greene, Jennifer, additional, Elraheb, Yasmine, additional, Redd, Alan, additional, Bian, John, additional, Restaino, John, additional, Norris, LeAnn, additional, Qureshi, Zaina, additional, Love, Bryan, additional, Bookstaver, Brandon, additional, Georgantopoulos, Peter, additional, Sartor, Oliver, additional, Raisch, Dennis, additional, Rao, Gowtham, additional, Lu, Kevin, additional, Ray, Paul, additional, Hrusheshky, William, additional, Schulz, Richard, additional, Ablin, Richard, additional, Noxon, Virginia, additional, and Bennett, Charles, additional

Published
2016
Full Text
View/download PDF

45. Antibiotic‐mediated bacteriome depletion in Apc<italic>Min/+</italic> mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression.

Author

Kaur, Kamaljeet, Saxena, Arpit, Debnath, Irina, O'Brien, Jacqueline L., Ajami, Nadim J., Auchtung, Thomas A., Petrosino, Joseph F., Sougiannis, Alexander‐Jacques, Depaep, Sarah, Chumanevich, Alexander, Gummadidala, Phani M., Omebeyinje, Mayomi H., Banerjee, Sourav, Chatzistamou, Ioulia, Chakraborty, Paramita, Fayad, Raja, Berger, Franklin G., Carson, James A., and Chanda, Anindya

Subjects
EXFOLIATIVE cytology, COLON cancer, CANCER invasiveness, ANTIBIOTICS, METAGENOMICS, GUT microbiome
Abstract

Abstract: Recent epidemiological evidence suggests that exposure to antibiotics in early‐to‐middle adulthood is associated with an increased risk of colorectal adenoma. However, mechanistic studies in established preclinical cancer to examine these claims are extremely limited. Therefore, we investigated the effect of long‐term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis. Clinical pathologies related to tumor development as well as intestinal and colon tissue histopathology were studied at ages 8, 12, and 16 weeks of age, which correspond to the approximate ages of development of neoplasia, gut inflammation with polyposis, and cancer progression, respectively, in this animal model. We show that the antibiotics significantly increase the severity of clinical symptoms, including effects on intestinal histology and goblet cell numbers. In addition, they promote small intestinal polyposis. Finally, metagenomic analysis of fecal samples demonstrated that antibiotic exposure is associated with a significant but nonuniform depletion of the animal's natural gut flora. Overall, these findings support the premise that long‐term antibiotic exposure mediates the selected depletion of gut microbial communities and the concomitant thinning of the protective mucus layer, resulting in an increase in tumor development. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results