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178 results on '"Favreau, Philippe"'

1. Time-resolved monitoring of polycyclic aromatic hydrocarbons adsorbed on atmospheric particles

Author

Sousa, Gustavo, Kiselev, Denis, Kasparian, Jérôme, George, Christian, Ferreira, José, Favreau, Philippe, Lazzarotto, Benoît, and Wolf, Jean-Pierre

Subjects
Physics - Atmospheric and Oceanic Physics, Physics - Instrumentation and Detectors
Abstract

Real-time monitoring of individual particles from atmospheric aerosols was performed by means of a specifically developed single-particle fluorescence spectrometer (SPFS). The observed fluorescence was assigned to particles bearing polycyclic aromatic hydrocarbons (PAH). This assignment was supported by an intercomparison with classical speciation on filters followed by gas chromatography-mass spectrometry (GC-MS) analysis. As compared with daily-averaged data, our time resolved approach provided information about the physicochemical dynamics of the particles. In particular, distinctions were made between background emissions related to heating, and traffic peaks during rush hours. Also, the evolution of the peak fluorescence wavelength provided an indication of the aging of the particles during the day., Comment: 8 pages, 6 figures

Published
2017
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2. Legacy and emerging plasticizers and stabilizers in PVC floorings : impacts of an industrial transition and recycling

Author

Wiesinger, Helene, Bleuler, Christophe, Christen, Verena, Favreau, Philippe, Hellweg, Stefanie, Langer, Miriam, Pasquettaz, Roxane, Schönborn, Andreas, Wang, Zhanyun, Wiesinger, Helene, Bleuler, Christophe, Christen, Verena, Favreau, Philippe, Hellweg, Stefanie, Langer, Miriam, Pasquettaz, Roxane, Schönborn, Andreas, and Wang, Zhanyun

Abstract

Hazardous chemicals in building and construction plastics can lead to health risks due to indoor exposure and may contaminate recycled materials. We systematically sampled new polyvinyl chloride floorings on the Swiss market (n = 151). We performed elemental analysis by X-ray fluorescence, targeted and suspect gas chromatography–mass spectrometry analysis of ortho-phthalates and alternative plasticizers, and bioassay tests for cytotoxicity and oxidative stress, and endocrine, mutagenic, and genotoxic activities (for selected samples). Surprisingly, 16% of the samples contained regulated chemicals above 0.1 wt %, mainly lead and bis(2-ethylhexyl) phthalate (DEHP). Their presence is likely related to the use of recycled PVC in new flooring, highlighting that uncontrolled recycling can delay the phase-out of hazardous chemicals. Besides DEHP, 29% of the samples contained other ortho-phthalates (mainly diisononyl and diisodecyl phthalates, DiNP and DiDP) above 0.1 wt %, and 17% of the samples indicated a potential to cause biological effects. Considering some overlap between these groups, they together make up an additional 35% of the samples of potential concern. Moreover, both suspect screening and bioassay results indicate the presence of additional potentially hazardous substances. Overall, our study highlights the urgent need to accelerate the phase-out of hazardous substances, increase the transparency of chemical compositions in plastics to protect human and ecosystem health, and enable the transition to a safe and sustainable circular economy.

Published
2024

22. A novel μ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

Author

Favreau, Philippe, Benoit, Evelyne, Hocking, Henry G, Carlier, Ludovic, Dʼhoedt, Dieter, Leipold, Enrico, Markgraf, René, Schlumberger, Sébastien, Córdova, Marco A, Gaertner, Hubert, Paolini-Bertrand, Marianne, Hartley, Oliver, Tytgat, Jan, Heinemann, Stefan H, Bertrand, Daniel, Boelens, Rolf, Stöcklin, Reto, and Molgó, Jordi

Published
2012
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23. A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity

Author

Favreau, Philippe, Gilles, Nicolas, Lamthanh, Hung, Bournaud, Roland, Shimahara, Takeshi, Bouet, Francoise, Laboute, Pierre, Letourneux, Yves, Menez, Andre, Molgo, Jordi, and Le Gall, Frederic

Subjects
Biochemistry -- Research, Calcium channels -- Physiological aspects, Amino acids -- Physiological aspects, Peptides -- Physiological aspects, Sulfides -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the voltage-sensitive calcium channel blocker isolated from the fish-hunting cone snail's venom. Results indicate that this peptide consists of amino acid residues folded by the disulfide bridges and represents a tool for blocking N-type voltage-sensitive calcium channels.

Published
2001

27. Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

Author

Moyer, Bryan D., primary, Murray, Justin K., additional, Ligutti, Joseph, additional, Andrews, Kristin, additional, Favreau, Philippe, additional, Jordan, John B., additional, Lee, Josie H., additional, Liu, Dong, additional, Long, Jason, additional, Sham, Kelvin, additional, Shi, Licheng, additional, Stöcklin, Reto, additional, Wu, Bin, additional, Yin, Ruoyuan, additional, Yu, Violeta, additional, Zou, Anruo, additional, Biswas, Kaustav, additional, and Miranda, Les P., additional

Published
2018
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32. Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.

Author

Moyer, Bryan D., Murray, Justin K., Ligutti, Joseph, Andrews, Kristin, Favreau, Philippe, Jordan, John B., Lee, Josie H., Liu, Dong, Long, Jason, Sham, Kelvin, Shi, Licheng, Stöcklin, Reto, Wu, Bin, Yin, Ruoyuan, Yu, Violeta, Zou, Anruo, Biswas, Kaustav, and Miranda, Les P.

Subjects
SODIUM ions, VOLTAGE-gated ion channels, ELECTROPHYSIOLOGY, DORSAL root ganglia, MEDICAL screening
Abstract

Identification of voltage-gated sodium channel NaV1.7 inhibitors for chronic pain therapeutic development is an area of vigorous pursuit. In an effort to identify more potent leads compared to our previously reported GpTx-1 peptide series, electrophysiology screening of fractionated tarantula venom discovered the NaV1.7 inhibitory peptide JzTx-V from the Chinese earth tiger tarantula Chilobrachys jingzhao. The parent peptide displayed nominal selectivity over the skeletal muscle NaV1.4 channel. Attribute-based positional scan analoging identified a key Ile28Glu mutation that improved NaV1.4 selectivity over 100-fold, and further optimization yielded the potent and selective peptide leads AM-8145 and AM-0422. NMR analyses revealed that the Ile28Glu substitution changed peptide conformation, pointing to a structural rationale for the selectivity gains. AM-8145 and AM-0422 as well as GpTx-1 and HwTx-IV competed for ProTx-II binding in HEK293 cells expressing human NaV1.7, suggesting that these NaV1.7 inhibitory peptides interact with a similar binding site. AM-8145 potently blocked native tetrodotoxin-sensitive (TTX-S) channels in mouse dorsal root ganglia (DRG) neurons, exhibited 30- to 120-fold selectivity over other human TTX-S channels and exhibited over 1,000-fold selectivity over other human tetrodotoxin-resistant (TTX-R) channels. Leveraging NaV1.7-NaV1.5 chimeras containing various voltage-sensor and pore regions, AM-8145 mapped to the second voltage-sensor domain of NaV1.7. AM-0422, but not the inactive peptide analog AM-8374, dose-dependently blocked capsaicin-induced DRG neuron action potential firing using a multi-electrode array readout and mechanically-induced C-fiber spiking in a saphenous skin-nerve preparation. Collectively, AM-8145 and AM-0422 represent potent, new engineered NaV1.7 inhibitory peptides derived from the JzTx-V scaffold with improved NaV selectivity and biological activity in blocking action potential firing in both DRG neurons and C-fibers. [ABSTRACT FROM AUTHOR]

Published
2018
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33. Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

Author

Murray, Justin K., primary, Ligutti, Joseph, additional, Liu, Dong, additional, Zou, Anruo, additional, Poppe, Leszek, additional, Li, Hongyan, additional, Andrews, Kristin L., additional, Moyer, Bryan D., additional, McDonough, Stefan I., additional, Favreau, Philippe, additional, Stöcklin, Reto, additional, and Miranda, Les P., additional

Published
2015
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35. Corrigendum to “When everything converges: Integrative taxonomy with shell, DNA and venomic data reveals Conus conco, a new species of cone snails (Gastropoda: Conoidea)” [Mol. Phylogenet. Evol. 80 (2014) 186–192]

Author

Puillandre, Nicolas, primary, Stöcklin, Reto, additional, Favreau, Philippe, additional, Bianchi, Estelle, additional, Perret, Frédéric, additional, Rivasseau, Audrey, additional, Limpalaër, Loïc, additional, Monnier, Eric, additional, and Bouchet, Philippe, additional

Published
2015
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37. Chemical camouflage : a frog's strategy to co-exist with aggressive ants

Author

Rödel, Mark-Oliver, Brede, Christian, Hirschfeld, Mareike, Schmitt, Thomas, Favreau, Philippe, Stöcklin, Reto, Wunder, Cora, Mebs, Dietrich, Rödel, Mark-Oliver, Brede, Christian, Hirschfeld, Mareike, Schmitt, Thomas, Favreau, Philippe, Stöcklin, Reto, Wunder, Cora, and Mebs, Dietrich

Abstract

Whereas interspecific associations receive considerable attention in evolutionary, behavioural and ecological literature, the proximate bases for these associations are usually unknown. This in particular applies to associations between vertebrates with invertebrates. The West-African savanna frog Phrynomantis microps lives in the underground nest of ponerine ants (Paltothyreus tarsatus). The ants usually react highly aggressively when disturbed by fiercely stinging, but the frog is not attacked and lives unharmed among the ants. Herein we examined the proximate mechanisms for this unusual association. Experiments with termites and mealworms covered with the skin secretion of the frog revealed that specific chemical compounds seem to prevent the ants from stinging. By HPLC-fractionation of an aqueous solution of the frogs' skin secretion, two peptides of 1,029 and 1,143 Da were isolated and found to inhibit the aggressive behaviour of the ants. By de novo sequencing using tandem mass spectrometry, the amino acid sequence of both peptides consisting of a chain of 9 and 11 residues, respectively, was elucidated. Both peptides were synthesized and tested, and exhibited the same inhibitory properties as the original frog secretions. These novel peptides most likely act as an appeasement allomone and may serve as models for taming insect aggression.

Published
2013

38. Venin des cônes

Author

Favreau, Philippe, Le Gall, Frédéric, Molgó, Jordi, Outters-Lafaye, Michèle, and C. Bon

Subjects
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Published
2000

39. A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+-dependent mechanism

Author

Le Gall, Frédéric, Favreau, Philippe, Benoit, Evelyne, Mattei, César, Bouet, Françoise, Menou, Jean-Louis, Ménez, André, Letourneux, Yves, Molgó, Jordi, Département d'Ingénierie et d'Etudes des Protéines, CEN/Saclay, Laboratoire de neurobiologie cellulaire et moléculaire (NBCM), Centre National de la Recherche Scientifique (CNRS), Service d'anatomie et cytologie pathologiques [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Institut de Recherche pour le Développement (IRD), Muséum national d'Histoire naturelle (MNHN), Laboratoire des Substances Naturelles, Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes], and CHU Pontchaillou [Rennes]

Subjects
Motor Neurons, Neurotransmitter Agents, Behavior, Animal, [SDV]Life Sciences [q-bio], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Molecular Sequence Data, Snails, Sodium, Fishes, Neuromuscular Junction, Presynaptic Terminals, Action Potentials, Mollusk Venoms, Synaptic Transmission, Axons, Mass Spectrometry, Sodium Channels, Electrophysiology, Ranvier's Nodes, Animals, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Amino Acid Sequence, Conotoxins, Ion Channel Gating
Abstract

International audience; A novel conotoxin was isolated and characterized from the venom of the fish-hunting marine snail Conus consors. The peptide was identified by screening chromatography fractions of the crude venom that produced a marked contraction and extension of the caudal and dorsal fins in fish, and noticeable spontaneous contractions of isolated frog neuromuscular preparations. The peptide, named CcTX, had 30 amino acids and the following scaffold: X11CCX7CX2CXCX3C. At the frog neuromuscular junction, CcTx at nanomolar concentrations selectively increased nerve terminal excitability so that a single nerve stimulation triggered trains of repetitive or spontaneous synaptic potentials and action potentials. In contrast, CcTx had no noticeable effect on muscle excitability even at concentrations 100 x higher than those that affected motor nerve terminals, as revealed by direct muscle stimulation. In addition, CcTx increased miniature endplate potential (MEPP) frequency in a Ca2+-free medium supplemented with ethylene glycol-bis-(beta-aminoethyl ether)-N,N,N', N'-tetraacetic acid (EGTA). Blockade of voltage-dependent sodium channels with tetrodotoxin (TTX) either prevented or suppressed the increase of MEPP frequency induced by the toxin. CcTx also produced a TTX-sensitive depolarization of the nodal membrane in single myelinated axons giving rise, in some cases, to repetitive and/or spontaneous action potential discharges. In addition, CcTx increased the nodal volume of myelinated axons, as determined using confocal laser scanning microscopy. This increase was reversed by external hyperosmolar solutions and was prevented by pretreatment of axons with TTX. It is suggested that CcTx, by specifically activating neuronal voltage-gated sodium channels at the resting membrane potential, produced Na+ entry into nerve terminals and axons without directly affecting skeletal muscle fibres. CcTx belongs to a novel family of conotoxins that targets neuronal voltage-gated sodium channels.

Published
1999
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42. Recruitment of Glycosyl Hydrolase Proteins in a Cone Snail Venomous Arsenal: Further Insights into Biomolecular Features of Conus Venoms

Author

Violette, Aude, primary, Leonardi, Adrijana, additional, Piquemal, David, additional, Terrat, Yves, additional, Biass, Daniel, additional, Dutertre, Sébastien, additional, Noguier, Florian, additional, Ducancel, Frédéric, additional, Stöcklin, Reto, additional, Križaj, Igor, additional, and Favreau, Philippe, additional

Published
2012
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45. Proteomics application exercise of the Swiss Proteomics Society: Report of the SPS'02 session

Author

Binz, Pierre-Alain, primary, Abdi, Fadi, additional, Affolter, Michael, additional, Allard, Laure, additional, Barblan, Jachen, additional, Bhardwaj, Sanjeev, additional, Bienvenut, Willy V., additional, Bulet, Philippe, additional, Burgess, Jennifer, additional, Carrette, Odile, additional, Corthals, Garry, additional, Delalande, François, additional, Diemer, Hélène, additional, Favreau, Philippe, additional, Giuliano, Elia, additional, Gueguen, Yannick, additional, Guillaume, Elisabeth, additional, Hahner, Stephanie, additional, Man, Petr, additional, Michalet, Sophie, additional, Neri, Dario, additional, Noukakis, Dimitrios, additional, Palagi, Patricia, additional, Paroutaud, Pierre, additional, Carvalho Pimenta, Daniel, additional, Quadroni, Manfredo, additional, Resemann, Anja, additional, Richert, Sophie, additional, Rybak, Jascha, additional, Sanchez, Jean-Charles, additional, Scherl, Alexander, additional, Scheurer, Simone, additional, Schweiger Hufnagel, Ulrike, additional, Siethoff, Christoph, additional, Suckau, Detlev, additional, van Dorsselaer, Alain, additional, Wagner Redeker, Winfried, additional, Walter, Nadia, additional, and Stöcklin, Reto, additional

Published
2003
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48. Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors

Author

Favreau, Philippe, Krimm, Isabelle, Le Gall, Frederic, Bobenrieth, Marie-Joelle, Lamthanh, Hung, Bouet, Francoise, Servent, Denis, Molgo, Jordi, Menez, Andre, Letourneux, Yves, and Lancelin, Jean-Marc

Subjects
Snails -- Physiological aspects, Toxins -- Analysis, Insect venom -- Analysis, Peptides -- Analysis, Biological sciences, Chemistry
Abstract

Two new alpha-conotoxins have been isolated from the venom of the fish-hunting cone snail, Conus consors. These snails have toxins that inhibit nicotinic acetylcholine receptors as well as sodium, potassium and calcium channels. Their properties and structures were studied by screening high-performance liquid chromatography and by binding with Torpedo nicotinic acetylcholine receptor. The alpha-CnIA toxin has 14 amino acids while the alpha-CnIB has 12. The former is the main conotoxin in the venom while the latter is present in small amounts.

Published
1999

49. Biochemical Characterization and Nuclear Magnetic Resonance Structure of Novel α-Conotoxins Isolated from the Venom of Conus consors,

Author

Favreau, Philippe, primary, Krimm, Isabelle, additional, Le Gall, Frédéric, additional, Bobenrieth, Marie-Joëlle, additional, Lamthanh, Hung, additional, Bouet, Françoise, additional, Servent, Denis, additional, Molgo, Jordi, additional, Ménez, André, additional, Letourneux, Yves, additional, and Lancelin, Jean-Marc, additional

Published
1999
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