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1. Notch3 is required for arterial identity and maturation of vascular smooth muscle cells

Author

Domenga, Valerie, Krebs, Luke T., Klonjkowski, Bernard, Berrou, Eliane, Mericskay, Matthias, Zhen Li, Tournier-Lasserve, Elisabeth, Gridley, Thomas, Joutel, Anne, Fardoux, Peggy, Lacombe, Pierre, Monet, Marie, and Maciazek, Jacqueline

Subjects
Mice as laboratory animals -- Research, Vascular smooth muscle -- Research, Biological sciences
Abstract

Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC) and that Notch3 is required for arterial specification of vSMC but not of endothelial cells. The data from observation on Notch3 mice reveal Notch3 to be first cell-autonomous regulator of arterial differentiation and maturation of vSMC.

Published
2004

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