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Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
- Source :
- Genes & Development. Nov 15, 2004, Vol. 18 Issue 22, 2710-2735
- Publication Year :
- 2004
-
Abstract
- Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC) and that Notch3 is required for arterial specification of vSMC but not of endothelial cells. The data from observation on Notch3 mice reveal Notch3 to be first cell-autonomous regulator of arterial differentiation and maturation of vSMC.
Details
- Language :
- English
- ISSN :
- 08909369
- Volume :
- 18
- Issue :
- 22
- Database :
- Gale General OneFile
- Journal :
- Genes & Development
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.127664290