1. Detectability of intracranial vessel wall atherosclerosis using black-blood spectral CT: a phantom and clinical study
- Author
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Fan Zhang, Hui Yao, Eran Langzam, Qinglin Meng, Xiao Meng, Rob J. van der Geest, Chuncai Luo, Tengyuan Zhang, Jianyong Li, Jianmei Xiong, Weiwei Deng, Ke Chen, Yangrui Zheng, Jingping Wu, Fang Cui, and Li Yang
- Subjects
Arteries ,Atherosclerosis ,Computed tomography angiography ,Phantoms (imaging) ,Stroke ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background Computed tomography (CT) is the usual modality for diagnosing stroke, but conventional CT angiography reconstructions have limitations. Methods A phantom with tubes of known diameters and wall thickness was scanned for wall detectability, wall thickness, and contrast-to-noise ratio (CNR) on conventional and spectral black-blood (SBB) images. The clinical study included 34 stroke patients. Diagnostic certainty and conspicuity of normal/abnormal intracranial vessels using SBB were compared to conventional. Sensitivity/specificity/accuracy of SBB and conventional were compared for plaque detectability. CNR of the wall/lumen and quantitative comparison of remodeling index, plaque burden, and eccentricity were obtained for SBB imaging and high-resolution magnetic resonance imaging (hrMRI). Results The phantom study showed improved detectability of tube walls using SBB (108/108, 100% versus conventional 81/108, 75%, p
- Published
- 2024
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