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Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Dysfunction of enteropeptidase (EP) can result in pancreatitis, a life-threatening disease. Yang et al. report a series of EP structures representing the EP catalytic cycle and propose a mechanistic model of enzyme function.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.36381ffcd27046e493edd387fc61342c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-34364-9